CN1168498C - Child 'xuebao' chewing tablet and preparing process thereof - Google Patents
Child 'xuebao' chewing tablet and preparing process thereof Download PDFInfo
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- CN1168498C CN1168498C CNB021370893A CN02137089A CN1168498C CN 1168498 C CN1168498 C CN 1168498C CN B021370893 A CNB021370893 A CN B021370893A CN 02137089 A CN02137089 A CN 02137089A CN 1168498 C CN1168498 C CN 1168498C
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Abstract
The present invention relates to a health care product, particularly to a Xuebao chewable tablet for children for preventing iron-deficiency anemia caused by child denutrition and a preparation method thereof. The Xuebao chewable tablet for children is prepared from white sugar, vitamin C, zinc lactate, hemoglobin, vitamin A, vitamin B2, folic acid, vitamin B12, etc. The preparation method comprises: the raw materials are thoroughly mixed step by step from the small to the large until the raw materials are uniformly mixed and stirred; the raw materials are pressed into tablets by using syrup as an adhesive agent and using magnesium stearate as a lubricant agent. The present invention has the advantages of high absorption rate, no side effect, simple process and low cost. The effect test of the test center for health care food function in the institute for nutrition and food sanitation of the Chinese disease control and prevention proves that the present invention can effectively improve child nutritional anemia.
Description
Technical field
The present invention relates to a kind of health food, child ' Xuebao ' chewing tablet of the iron deficiency anemia that causes especially for the prevention child lacks nutrition and preparation method thereof.
Background technology
Iron deficiency anemia is common Deficiency disease, and the whole world is popularized in morbidity, is more common in infant, child, teenager, anemia of pregnant woman, wet nurse and the aged.By the standard of World Health Organization (WHO), anemia person accounts for 30% of world population, and children's's sickness rate can reach 52%, and it has a strong impact on child's growth, growth, intelligence and resistance against diseases.People study and inquire into its cause of disease and prophylactico-therapeutic measures always for many years, and wherein iron supplement is an important effective way improving iron deficiency anemia.
Iron deficiency anemia is the interior disease that lacks hemopoietic raw material ferrum and cause of children's's body, generally just can improve anemia state very soon behind the additional chalybeate.Yet, even the regular additional chalybeate of the iron deficiency anemia infant that has also can not make its hematochrome rise.
The medicine of well-known treatment anemia is a lot, iron supplement agent commonly used at present is the inanimate medicine that the organic or inorganic chemistry is made with artificial synthesis, exist the interior absorption rate of human body low, and its abnormal flavour often make problems such as patient's inappetence and gastrointestinal side effect.Child ' Xuebao ' chewing tablet of the present invention is to adopt the haemachrome that extracts in the Sanguis sus domestica of abundant raw material as raw material, is equipped with other vitamin and trace element and makes to have and improve the nourish one's nature chewable tablet of anemia of juvenile camp.Can effectively improve juvenile camp's anemia of nourishing one's nature.For child ' Xuebao ' chewing tablet raw materials used we do following introduction:
Haemachrome: can be decomposed into protoporphyrin and ferrous iron by the human body epithelial cell, be absorbed by body and utilize thereby enter blood, without any side effect.
Vitamin C: also claim ascorbic acid, have many important function in human body, it can promote the more ferrum of intestinal absorption, and with Fe
3+Be reduced into Fe
2+Ascorbic acid can also help ferrum to transfer on the ferritin from the carrier transferrins.Vitamin C can strengthen the activity of some iron enzyme.
Vitamin A: it is reported that vitamin A deficiency and anemia have the collaborative trend that occurs, and along with severity of anemia increases the weight of, the vitamin A deficiency rate increases, along with vitamin a level reduces, the anemia prevalence increases.Studies show that vitamin A can improve absorption, running and the distribution of body to ferrum, promote hemopoietic function.When vitamin A deficiency, transferrin is synthetic limited, and storage iron is released into the blood obstacle, causes the bone marrow iron deficiency, and hematopoietic potential is descended.
Vitamin B
2: claiming riboflavin again, is the important composition composition of many enzyme systems in the body, the B if body is deficient in vitamin
2, the matter and energy metabolism disorder can appear.Vitamin B
2Also be to constitute erythrocytic important substance.Studies have shown that it is to promoting the important effect that is absorbed with of ferrum, the existing report B that is deficient in vitamin
2The anemia of pregnant woman iron deficiency anemia takes place easily.An amount of vitamin B
2Picked-up is highly profitable to the prevention status of iron deficiency in pregnant women.Prove vitamin B thus
2Effect to iron deficiency anemia.
Vitamin B
12: claim cobalamine again, because contain the trace element cobalt of human body needs at its intramolecularly, it has multiple effect, and as the adjusting material of organism metabolism, it has the ability that the human body hematopoietic function is in normal condition, and pernicious anemia takes place during shortage.
Folic acid: in liver, seek and a kind ofly find can treat the pernicious anemia material time.Be the main running carrier of one-carbon unit in the body, under situation about lacking, can produce macrocytic anemia.Medical survey shows that the folic acid deficiency person accounts for 48.1% in the infant of trouble nutritional anemia, and this shows that the generation of anemia and the shortage of folic acid have confidential relation.
Zinc: be the constituent or the activator of many metalloenzyme, the activity of kind of enzyme is relevant with zinc surplus in the of known so far 80, as carbonic anhydrase alcoholdehydrogenase, alkali phosphatase, carboxypeptidase, aspartate carbamyl-transferase, amino peptidase etc.Synthetic and metabolism, the normal ossification of skeleton, genitals's the growth and the function of protein, nucleic acid all need zinc.Zinc can be safeguarded the health of normal taste function and skin, in addition, also is essential to the function of vision, audition, olfactory sensation.Medical research shows that also the shortage of trace element such as the generation of iron deficiency anemia and zinc, copper is closely related.
Summary of the invention
The purpose of this invention is to provide a kind of human absorptivity's height, have no side effect, production technology is simple, cost is low, and can effectively improve juvenile camp's child ' Xuebao ' chewing tablet of anemia and preparation method thereof of nourishing one's nature.
Consisting of of child ' Xuebao ' chewing tablet: white sugar 850 ~ 950g; Vitamin C 80 ~ 120g; Zinc lactate 8 ~ 12g; Haemachrome 6 ~ 8g; Vitamin A 4 ~ 6g; Vitamin B
2800 ~ 1000mg; Folic acid 100 ~ 500mg; Vitamin B
121 ~ 5mg.
The preparation method of child ' Xuebao ' chewing tablet is with vitamin B
2, folic acid, B
12After fully mixing, add haemachrome, vitamin A, zinc lactate one by one, and fully mix one by one, divide secondary to add vitamin C again, fully mix, at last the white sand sugar is added for three times, all fully mix and stir, until last uniform mixing, be that binding agent is made granule with syrup at every turn then, cure into dried granule in 55 ℃ ~ 60 ℃ temperature, the reuse magnesium stearate is made the lubricant tabletting.
Product safety of the present invention is effective.Through the food acute toxicity test, toxicology test shows that this product belongs to nontoxic, does not see mutagenic action, does not also see the overt toxicity reaction.
Improve nutritional anemia zoopery result through Chinese Academy Of Preventive Medicine Research Institute Of Nutrition And Food Hygiene health food functional check center and show, rat oral gavage gives child ' Xuebao ' chewing tablet can significantly increase rat after 6 weeks content of hemoglobin and packed cell volume level (significant difference P＜0.05).The free erythrocyte protoporphyrin content of each dosage group of experiment back all significantly is lower than iron deficiency matched group (P＜0.05).Give iron content in spleen that child ' Xuebao ' chewing tablet significantly increases rat and the liver, and experimental group is significantly higher than matched group, according to the criterion in " the health food function assessment assessment process and the method for inspection ", child ' Xuebao ' chewing tablet can improve the nutritional anemia of rat effectively.
Child ' Xuebao ' chewing tablet is to the nutritional anemia human feeding trial, and dose is secondary every day, and each a slice (0.5 gram/sheet, actual measurement iron-holder 2.21mg/g) is equivalent to child's per kilogram of body weight 0.025 gram (in 40kg).The test crowd is 6 ~ 13 years old anemia child, and content of hemoglobin is all less than 120g/l, 45 days time.
Purpose: after giving that the experimenter of nutritional anemia is edible and being tried thing, observe and tried thing and whether can cause experimenter's content of hemoglobin, the increase of packed cell volume, and the minimizing of free erythrocyte protoporphyrin content.
1, child ' Xuebao ' chewing tablet is to the influence of anemia child content of hemoglobin.The results are shown in Table 1.Before the test content of hemoglobin of matched group test-meal group do not have significant difference (T=0.104, P=0.917).The content of the hemoglobin of test back test-meal group be significantly higher than matched group (T=3.387, P=0.001).With the test before compare, during off-test the content of the hemoglobin of test-meal group and matched group all than the test before remarkable increase is arranged.
Table 1 child ' Xuebao ' chewing tablet is to the influence of anemia child content of hemoglobin (g/L)
Value added T value P value in test back before the test of group experimenter's number
Matched group 49 113.5 ± 125.0 ± 6.9 11.6 ± 8.2
c9.799 0.000
Test-meal group 50 4.6 129.8 ± 16.5 ± 10.985 0.000
T value 113.3 ± 7.2** 10.6
c*
P value 7.4 3.387 2.577
0.104 0.001 0.011
0.917
Compare * P＜0.05 with matched group, * * P＜0.05, with the test before compare c P＜0.001
2, child ' Xuebao ' chewing tablet the results are shown in Table 2 to the influence of anemia child packed cell volume.The packed cell volume of matched group and test-meal group does not have significant difference (T=0.864 and P=0.390) before the test.The packed cell volume of test back test-meal group be significantly higher than matched group (T=2.728, P=0.008).Compare before test-meal group and matched group packed cell volume and the test during off-test remarkable increase is all arranged.
Table 2 child ' Xuebao ' chewing tablet is to the influence of anemia child packed cell volume (%)
Value added T value P value in test back before the test of group experimenter's number
Matched group 49 34.4 ± 2.8 36.9 ± 2.2 2.6 ± 3.6
c5.065 0.000
Test-meal group 50 33.9 ± 2.3 38.1 ± 1.8** 4.2 ± 3.0
c* 9.593 0.000
T value 0.864 2.728 2.368
P value 0.390 0.008 0.020
Compare * P＜0.05 with matched group, * * P＜0.01 is P＜0.001 with comparing c before the test
3, child ' Xuebao ' chewing tablet the results are shown in Table 4 to the influence of anemia child free erythrocyte protoporphyrin content.Before the test free erythrocyte protoporphyrin content of matched group and test-meal group do not have significant difference (T=1.125, P=0.224); After the test-meal test-meal group child's free erythrocyte protoporphyrin content significantly be lower than the matched group child (T=2.421, P=0.017); With compare before the test, the free erythrocyte protoporphyrin content of test back test-meal group and matched group all significantly is lower than the level before its test.
Table 3 child ' Xuebao ' chewing tablet is to the influence of anemia child free erythrocyte protoporphyrin content (μ g/dl)
Value added T value P value in test back before the test of group experimenter's number
Matched group 49 64.9 ± 37.4 ± 15.4-27.5 ± 5.980 0.000
Test-meal group 50 31.4 30.2 ± 13.4* 31.2
c7.769 0.000
T value 73.3 ± 2.421 43.1 ±
P value 34.4 0.017 38.0
c*
1.225 2.164
0.224 0.033
Compare * P＜0.05 with matched group, with the test before compare c P＜0.001.
4, result.
Show through 45 days human feeding trial results, take can significantly raise anemia child's hemoglobin level of child ' Xuebao ' chewing tablet, the difference of comparing with matched group significance (P＜0.05); Take also can significantly raise anemia child's packed cell volume level of child ' Xuebao ' chewing tablet, obviously reduce free erythrocyte protoporphyrin content, the difference of comparing with matched group has significant statistical significance (P＜0.05); And the difference before and after the test of test-meal group is compared significant difference with matched group and is had significance.According to the criterion in " the health food function assessment assessment process and the method for inspection ", child ' Xuebao ' chewing tablet can improve child's nutritional anemia effectively.
The property of the present invention is directed to is strong, take object for children, use the haemachrome that extracts in the Sanguis sus domestica to be the raw material of mainly enriching blood, the absorbance height, without any side effects, technology is simple, cost is low, be equipped with other vitamin and trace element and make, the anemia that a variety of causes is caused can both be effectively controlled.
The specific embodiment
Elaborate below in conjunction with embodiment
Embodiment 1
Must meet the related standards regulation and just checked and accepted various supplementary materials in the prescription, all raw materials are all crossed behind 100 mesh sieves standby.With vitamin B
121mg, vitamin B
21000mg, folic acid 500mg fully mix and stir, add haemachrome 10g then one by one, vitamin A 6g, zinc lactate 12g, mix and stir one by one, divide secondary to add vitamin C 120g altogether again, fully mix and stir one by one, divide three addings with white sugar by the amount of 150g, 250g, 450g at last, all fully mix and stir at every turn until final uniform mixing, do binding agent with syrup then and make granule, in 55 ~ 60 ℃ of temperature, cure into dried granule, dried granule is crossed 30 mesh sieve granulate after, make lubricant with magnesium stearate, use the tabletting machine moulding, obtain child ' Xuebao ' chewing tablet.
Embodiment 2
With vitamin B
122mg, vitamin B
2The formula proportion of 900mg, folic acid 200mg accurately takes by weighing each supplementary material, mix in the blender and stirred 15 minutes, make its abundant mixing, add haemachrome 6g then one by one, vitamin A 5g, zinc lactate 10g, mix and stir one by one, divide secondary to add vitamin C 100g altogether again, fully mix and stir one by one, divide three addings with white sugar by the amount of 150g, 300g, 428g at last, all fully mix and stir at every turn, until final uniform mixing, do binding agent with syrup then and make granule, make the lubricant tabletting with magnesium stearate and form.
Embodiment 3
With vitamin B
121mg, vitamin B
2800mg, folic acid 100mg fully mix and stir, add haemachrome 8g then one by one, vitamin A 4g, zinc lactate 8g mixes and stirs one by one, divide secondary to add vitamin C 80g altogether again, fully mix and stir one by one, divide three addings with white sugar by the amount of 150g, 400g, 399g at last, all fully mix and stir at every turn until final uniform mixing, do binding agent with syrup then, make the lubricant tabletting with magnesium stearate and form.
Claims (2)
1, a kind of child ' Xuebao ' chewing tablet is characterized in that consisting of of it: white sugar 850～950g; Vitamin C 80～120g; Zinc lactate 8～12g; Haemachrome 6～10g; Vitamin A 4～6g; Vitamin B
2800～1000mg; Folic acid 100～500mg; Vitamin B
121～5mg.
2, a kind of preparation method of child ' Xuebao ' chewing tablet is characterized in that vitamin B
2, folic acid, B
12After fully mixing, add haemachrome, vitamin A, zinc lactate one by one, and fully mix one by one, divide secondary to add vitamin C again, fully mix, at last the white sand sugar is added for three times, all fully mix and stir, until last uniform mixing, be that binding agent is made granule with syrup at every turn then, cure into dried granule in 55 ℃～60 ℃ temperature, the reuse magnesium stearate is made the lubricant tabletting.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021370893A CN1168498C (en) | 2002-09-19 | 2002-09-19 | Child 'xuebao' chewing tablet and preparing process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021370893A CN1168498C (en) | 2002-09-19 | 2002-09-19 | Child 'xuebao' chewing tablet and preparing process thereof |
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| Publication Number | Publication Date |
|---|---|
| CN1401388A CN1401388A (en) | 2003-03-12 |
| CN1168498C true CN1168498C (en) | 2004-09-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8514042B2 (en) | 2010-09-17 | 2013-08-20 | Apple Inc. | Magnetic attachment system |
| US9568954B2 (en) | 2010-09-17 | 2017-02-14 | Apple Inc. | Cover for an electronic device |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100344326C (en) * | 2005-09-30 | 2007-10-24 | 北京康比特威创体育新技术发展有限公司 | Iron-supplementing preparation |
| CN102429150A (en) * | 2011-12-15 | 2012-05-02 | 广东汤臣倍健生物科技股份有限公司 | Vitamin C chewable tablets for enhancing human immunity |
| CN106820157A (en) * | 2017-01-18 | 2017-06-13 | 深圳泰乐德营养与健康有限公司 | One kind is applied to teen-age health food |
-
2002
- 2002-09-19 CN CNB021370893A patent/CN1168498C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8514042B2 (en) | 2010-09-17 | 2013-08-20 | Apple Inc. | Magnetic attachment system |
| US9568954B2 (en) | 2010-09-17 | 2017-02-14 | Apple Inc. | Cover for an electronic device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1401388A (en) | 2003-03-12 |
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| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20040929 Termination date: 20120919 |