CN116832148A - 一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法 - Google Patents
一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法 Download PDFInfo
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Abstract
本发明公开了一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,包括第一步,进行原材料的准备,原材料包括沙棘、红豆杉、生物蛋白、VC、艾和基础凝胶材料;第二步,进行原材料的处理和提取;第三步,进行初步混合,得到混合基液;第四步,向混合基液中加入生物蛋白和VC,得到基础胶液;第五步,向基础胶液内添加功能助剂,得到凝胶;第六步,进行凝胶的检查和调整。本发明在制备的过程中首先制备沙棘提取物、红豆杉提取物和艾提取物,这样将原料中的精华提炼出来,使得原料的使用减少了一些杂质的干扰,同时在挤出胶液内添加功能助剂,使得原料的能够得以稳定的实施药性的发挥,使得制备出来的凝胶疗效更好。
Description
技术领域
本发明涉及妇科医药制备领域,特别涉及一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法。
背景技术
妇科凝胶是用于妇科保健和治疗的产品,为凝胶剂,用于各种妇科阴道炎、宫颈炎的治疗,包括:细菌性阴道炎、滴虫性阴道炎、混合性阴道炎、淋球菌感染、慢性宫颈炎。
现有的妇科凝胶其功能性多为紧致、抗炎和抗菌作用,且一种凝胶也只是单独具备一种或者两种功能,在这类凝胶的制备过程中,现有的制备方式只是进行原来的基础混合制备,即多是只进行简单搅拌混合,这样的原料混合方式使得原料的材质特性没有得到更好地发挥,且现有的凝胶制备原料无法满足抗氧化滋养的效用,使得凝胶的功能不足以满足现在的保健需求。
发明内容
本发明的目的在于提供一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,以解决上述背景技术中提出的问题。
为实现上述目的,本发明提供如下技术方案:一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,所述制备方法包括以下几个步骤;
第一步,进行原材料的准备,准备的原材料包括沙棘、红豆杉、生物蛋白、VC、艾和基础凝胶材料;
第二步,进行原材料的处理和提取,所述原材料的处理包括原材料的筛选和清洗,所述原材料的提取包括制备沙棘提取物、红豆杉提取物和艾提取物;
第三步,进行初步混合,将沙棘提取物、红豆杉提取物和艾提取物按照1:0.8:0.3依次投入至搅拌罐中,然后加入基础凝胶材料进行搅拌混合,得到混合基液;
第四步,向混合基液中加入生物蛋白和VC,进行加热搅拌,得到基础胶液;
第五步,向基础胶液内添加功能助剂,所述功能助剂包括PH调节剂、乳化剂、抗氧化剂和稳定剂,且在添加的过程中进行持续的搅拌,得到凝胶;
第六步,进行凝胶的检查和调整,对制备的凝胶进行性能的测试,若是性能测试不合格则需要进行调整。
优选的,所述第二步原材料的处理包括以下几个步骤;
S1,向将待处理的原料投入至清洗桶内,将混杂在果堆中的枝叶和杂草挑除;
S2,向清洗桶内的注水,待到水体完全浸没桶内的原料;
S3,进行翻搅,在翻搅的过程中,将漂浮的一些杂质和碎屑去除,之后进行果体表面搓洗,然后通过翻滚挑拣出坏果;
S4,倒出S3中剩余的原料,然后进行冲洗,冲洗完成之后进行阴干。
优选的,所述第二步中沙棘提取物、红豆杉提取物和艾提取物的制备包括以下几个步骤;
A1,将处理好的沙棘、红豆杉和艾投入到破碎机中进行破碎,将原材料破碎至泥状;
A2,向打碎成泥状的原料内加入乙醇溶剂进行混合浸泡,且在混合的过程中以80-120r/s的速度进行搅拌;
A3,对混合好的溶液进行加热提取,控制温度在45-60℃,维持1.5-2h,得到提取液;
A4,进行提取液的过滤和分离,将提取液投入至离心机中,进行过滤分离,去除固体残渣和悬浮物,得到过滤液;
A5,进行过滤液的浓缩和干燥,将得到的过滤液使用旋转蒸发器进行浓缩,然后再使用真空干燥法进行干燥。
优选的,所述第三步中混合基液的制备,是将沙棘提取物、红豆杉提取物、艾提取物和基础凝胶材料投入至加热搅拌罐中,边加热边进行搅拌,加热的温度在60-75℃,且搅拌的转速为200-350r/min,持续时间2-2.5h。
优选的,所述基础凝胶材料包括明胶和羊齿植物胶中的一种或多种。
优选的,所述基础胶液的制备的加热温度为50-65℃,且搅拌的转速为150-250r/min,待到所有的生物蛋白和VC加入完毕之后,持续加热搅拌10-15min。
优选的,所述生物蛋白包括胶原蛋白、凝血蛋白和弹力蛋白中的一种或多种。
优选的,所述第五步中PH调节剂包括柠檬酸、乳酸和碳酸氢钠。
优选的,所述第五步中乳化剂包括聚山梨醇酯、卵磷脂和磷酸二酰甘油酯。
优选的,所述第五步中稳定剂包括羟丙基甲基纤维素、聚丙烯酸钠和聚乙烯吡咯烷酮。
本发明的技术效果和优点:
(1)本发明在制备的过程中首先制备沙棘提取物、红豆杉提取物和艾提取物,这样将原料中的精华提炼出来,使得原料的使用减少了一些杂质的干扰,同时在挤出胶液内添加功能助剂,这样通过PH调节剂、乳化剂、抗氧化剂和稳定剂的投入,使得原料的能够得以稳定的实施药性的发挥,使得制备出来的凝胶疗效更好;
(2)本发明的原料包括沙棘、红豆杉、生物蛋白、VC和艾,通过这些原料的添加,使得本方法制备出来的凝胶能够具有抗氧化、提升紧致和滋养的功效,使得本品制备的凝胶保健效果更好。
附图说明
图1为本发明整体的制备方法流程图。
图2为本发明原材料的处理流程示意图。
图3为本发明提取物制备的操作流程示意图。
具体实施方式
下面将结合本发明实施例中的附图,对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
本发明提供了如图1-3所示的一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,制备方法包括以下几个步骤;
第一步,进行原材料的准备,准备的原材料包括沙棘、红豆杉、生物蛋白、VC、艾和基础凝胶材料;
第二步,进行原材料的处理和提取,原材料的处理包括原材料的筛选和清洗,原材料的提取包括制备沙棘提取物、红豆杉提取物和艾提取物;
需要说明的是,沙棘提取物为胡颓子科植物中国沙棘和云南沙棘的果实,具有止咳化痰、健胃消食、活血散瘀的功效,被广泛用于护肤品和保健品中,因为它具有多种益处和功效,包括抗氧化作用:沙棘提取物富含维生素C、维生素E、类胡萝卜素和多酚等抗氧化物质,可以帮助中和自由基,减少氧化应激对皮肤的损害。皮肤保湿和滋养:沙棘提取物含有丰富的脂肪酸,如欧米伽-3、欧米伽-6和欧米伽-9,这些脂肪酸有助于保持皮肤的水分和滋润度。抗炎和修复:沙棘提取物具有抗炎和修复受损皮肤的作用,可舒缓敏感、红肿和刺激,并促进皮肤的自我修复过程。促进胶原蛋白合成:沙棘提取物中的某些成分被认为可以促进胶原蛋白的合成,有助于改善皮肤的弹性和紧致度。
红豆杉提取物是从红豆杉树木中提取的活性成分,红豆杉是一种常见的针叶树,其树皮、树叶和树枝中含有一种叫做紫杉醇(paclitaxel)的化合物,被广泛用于医药领域。红豆杉提取物具有多种药用和生物活性特性,包括抗肿瘤作用:红豆杉提取物中的紫杉醇是一种抗肿瘤药物,被用于治疗多种癌症,如乳腺癌、卵巢癌和肺癌等。它通过干扰肿瘤细胞的分裂过程,阻止肿瘤的生长和扩散。抗氧化作用:红豆杉提取物富含多种抗氧化物质,如黄酮类化合物和多酚类化合物,可以中和自由基,减少氧化应激对身体的损害。抗炎作用:红豆杉提取物具有一定的抗炎作用,可以减轻炎症反应和炎症引起的不适。
艾提取物是从艾草中提取的活性成分。艾草是一种常见的草本植物,被广泛用于传统草药和中医药中。艾提取物具有多种药用和生物活性特性,包括抗菌和抗炎作用:艾提取物中的活性成分具有一定的抗菌和抗炎作用,可以抑制细菌和炎症反应,有助于皮肤的清洁和舒缓。抗氧化作用:艾提取物富含多种抗氧化物质,如黄酮类化合物和多酚类化合物,可以中和自由基,减少氧化应激对皮肤的损害。促进血液循环:艾提取物被认为可以促进血液循环,有助于改善皮肤的血液供应和营养输送。抗过敏和抗瘙痒:艾提取物具有一定的抗过敏和抗瘙痒作用,可以缓解皮肤过敏反应和瘙痒不适。
具体的,第二步原材料的处理包括以下几个步骤;
S1,向将待处理的原料投入至清洗桶内,将混杂在果堆中的枝叶和杂草挑除,在清洗时也可以直接将原料投入至清洗池中,其所铺设的面积越大,各果粒所占有的空间越多,那么进行挑选起来越方便,也越细致,确保原材料的质量和纯度;
S2,向清洗桶内的注水,待到水体完全浸没桶内的原料;
S3,进行翻搅,在翻搅的过程中,将漂浮的一些杂质和碎屑去除,之后进行果体表面搓洗,然后通过翻滚挑拣出坏果;
注意,在进行果体的搓洗的过程中,只是为了将果体表面粘连的泥污与果体表面分离,在搓洗的过程中避免果体表面破裂,以免果体内的药用成分流失。
S4,倒出S3中剩余的原料,然后进行冲洗,冲洗完成之后进行阴干。
具体的,第二步中沙棘提取物、红豆杉提取物和艾提取物的制备包括以下几个步骤;
A1,将处理好的沙棘、红豆杉和艾投入到破碎机中进行破碎,将原材料破碎至泥状;
需要说明的是,将原材料即果体破碎成0.0625mm-2mm,这样能够有助于原材料中各成分的分离提取。
A2,向打碎成泥状的原料内加入乙醇溶剂进行混合浸泡,且在混合的过程中以80-120r/s的速度进行搅拌;
需要说明的是,在浸泡的原材料泥的过程中,溶剂会逐渐提取出其中的活性成分,且对于该成分的提取还可以包括超声波提取和加热提取,提取时间和温度可以根据需要进行调整。
A3,对混合好的溶液进行加热提取,控制温度在45-60℃,维持1.5-2h,得到提取液;
A4,进行提取液的过滤和分离,将提取液投入至离心机中,进行过滤分离,去除固体残渣和悬浮物,得到过滤液,该步骤中过滤也可以使用滤纸或者滤网执行,采用离心机可以加速过滤的过程;
A5,进行过滤液的浓缩和干燥,将得到的过滤液使用旋转蒸发器进行浓缩,然后再使用真空干燥法进行干燥。
需要说明的是,浓缩的操作是为了去除多余的溶剂,且进行干燥的方法还可以包括喷雾干燥和冷冻干燥,本方案中采用真空干燥法是避免提取的活性物质失活,使得提取物能够发挥更好的效果。
第三步,进行初步混合,将沙棘提取物、红豆杉提取物和艾提取物按照1:0.8:0.3依次投入至搅拌罐中,然后加入基础凝胶材料进行搅拌混合,得到混合基液;
具体的,第三步中混合基液的制备,是将沙棘提取物、红豆杉提取物、艾提取物和基础凝胶材料投入至加热搅拌罐中,边加热边进行搅拌,加热的温度在60-75℃,且搅拌的转速为200-350r/min,持续时间2-2.5h。
进一步的,基础凝胶材料包括明胶和羊齿植物胶中的一种或多种。
需要说明的是,明胶是一种常见的食品添加剂,它是从动物的结缔组织中提取的一种蛋白质。明胶主要由胶原蛋白组成,具有胶状的特性。明胶在食品工业中被广泛用作增稠剂、凝胶剂、稳定剂和乳化剂。除了食品工业,明胶还在医药、摄影、制药、化妆品等领域中有一定的应用。在医药领域,明胶常被用于制备胶囊、软膏和药片等药物剂型。
羊齿植物胶是一种天然植物胶,主要由羊齿植物的种子中提取而来。羊齿植物是一种常见的草本植物,广泛分布于全球各地。羊齿植物胶在食品和药品工业中被用作增稠剂、凝胶剂和稳定剂。它具有良好的胶凝性和黏性,能够增加食品的黏度和改善质地。羊齿植物胶常被用于制作果冻、果酱、糖果、冻品、面包、饼干等食品中,以增加其口感和稳定性。
第四步,向混合基液中加入生物蛋白和VC,进行加热搅拌,得到基础胶液;
具体的,基础胶液的制备的加热温度为50-65℃,且搅拌的转速为150-250r/min,待到所有的生物蛋白和VC加入完毕之后,持续加热搅拌10-15min。
进一步的,生物蛋白包括胶原蛋白、凝血蛋白和弹力蛋白中的一种或多种。
需要说明的是,胶原蛋白是一种主要存在于皮肤、骨骼、肌肉、血管等组织中的蛋白质。它具有保湿、滋润、增强弹性和促进组织修复的作用。
凝血蛋白是一种参与血液凝固过程的蛋白质,在妇科凝胶中可以起到促进伤口愈合和止血的作用。
弹力蛋白是一种在皮肤组织中起到支撑和弹性作用的蛋白质。它能够增加皮肤的弹性和紧致度,减少皱纹和松弛现象。
本方案中弹力蛋白在配方中对于整个凝胶的作用主要为提升紧致。
第五步,向基础胶液内添加功能助剂,功能助剂包括PH调节剂、乳化剂、抗氧化剂和稳定剂,且在添加的过程中进行持续的搅拌,得到凝胶;
具体的,第五步中PH调节剂包括柠檬酸、乳酸和碳酸氢钠。
pH调节剂用于调节凝胶的pH值,使其适合妇科使用,并提供最佳的稳定性。
具体的,第五步中乳化剂包括聚山梨醇酯、卵磷脂和磷酸二酰甘油酯。
乳化剂用于稳定油水乳液体系,使凝胶中的油相和水相能够均匀分散并保持稳定。
具体的,第五步中稳定剂包括羟丙基甲基纤维素、聚丙烯酸钠和聚乙烯吡咯烷酮。
稳定剂用于增加凝胶的稳定性,防止成分分离和沉淀。
第六步,进行凝胶的检查和调整,对制备的凝胶进行性能的测试,若是性能测试不合格则需要进行调整。
最后应说明的是:以上所述仅为本发明的优选实施例而已,并不用于限制本发明,尽管参照前述实施例对本发明进行了详细的说明,对于本领域的技术人员来说,其依然可以对前述各实施例所记载的技术方案进行修改,或者对其中部分技术特征进行等同替换,凡在本发明的精神和原则之内,所作的任何修改、等同替换、改进等,均应包含在本发明的保护范围之内。
Claims (10)
1.一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,其特征在于,所述制备方法包括以下几个步骤;
第一步,进行原材料的准备,准备的原材料包括沙棘、红豆杉、生物蛋白、VC、艾和基础凝胶材料;
第二步,进行原材料的处理和提取,所述原材料的处理包括原材料的筛选和清洗,所述原材料的提取包括制备沙棘提取物、红豆杉提取物和艾提取物;
第三步,进行初步混合,将沙棘提取物、红豆杉提取物和艾提取物按照1:0.8:0.3依次投入至搅拌罐中,然后加入基础凝胶材料进行搅拌混合,得到混合基液;
第四步,向混合基液中加入生物蛋白和VC,进行加热搅拌,得到基础胶液;
第五步,向基础胶液内添加功能助剂,所述功能助剂包括PH调节剂、乳化剂、抗氧化剂和稳定剂,且在添加的过程中进行持续的搅拌,得到凝胶;
第六步,进行凝胶的检查和调整,对制备的凝胶进行性能的测试,若是性能测试不合格则需要进行调整。
2.根据权利要求1所述的一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,其特征在于,所述第二步原材料的处理包括以下几个步骤;
S1,向将待处理的原料投入至清洗桶内,将混杂在果堆中的枝叶和杂草挑除;
S2,向清洗桶内的注水,待到水体完全浸没桶内的原料;
S3,进行翻搅,在翻搅的过程中,将漂浮的一些杂质和碎屑去除,之后进行果体表面搓洗,然后通过翻滚挑拣出坏果;
S4,倒出S3中剩余的原料,然后进行冲洗,冲洗完成之后进行阴干。
3.根据权利要求1所述的一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,其特征在于,所述第二步中沙棘提取物、红豆杉提取物和艾提取物的制备包括以下几个步骤;
A1,将处理好的沙棘、红豆杉和艾投入到破碎机中进行破碎,将原材料破碎至泥状;
A2,向打碎成泥状的原料内加入乙醇溶剂进行混合浸泡,且在混合的过程中以80-120r/s的速度进行搅拌;
A3,对混合好的溶液进行加热提取,控制温度在45-60℃,维持1.5-2h,得到提取液;
A4,进行提取液的过滤和分离,将提取液投入至离心机中,进行过滤分离,去除固体残渣和悬浮物,得到过滤液;
A5,进行过滤液的浓缩和干燥,将得到的过滤液使用旋转蒸发器进行浓缩,然后再使用真空干燥法进行干燥。
4.根据权利要求1所述的一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,其特征在于,所述第三步中混合基液的制备,是将沙棘提取物、红豆杉提取物、艾提取物和基础凝胶材料投入至加热搅拌罐中,边加热边进行搅拌,加热的温度在60-75℃,且搅拌的转速为200-350r/min,持续时间2-2.5h。
5.根据权利要求4所述的一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,其特征在于,所述基础凝胶材料包括明胶和羊齿植物胶中的一种或多种。
6.根据权利要求1所述的一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,其特征在于,所述基础胶液的制备的加热温度为50-65℃,且搅拌的转速为150-250r/min,待到所有的生物蛋白和VC加入完毕之后,持续加热搅拌10-15min。
7.根据权利要求6所述的一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,其特征在于,所述生物蛋白包括胶原蛋白、凝血蛋白和弹力蛋白中的一种或多种。
8.根据权利要求1所述的一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,其特征在于,所述第五步中PH调节剂包括柠檬酸、乳酸和碳酸氢钠。
9.根据权利要求1所述的一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,其特征在于,所述第五步中乳化剂包括聚山梨醇酯、卵磷脂和磷酸二酰甘油酯。
10.根据权利要求1所述的一种抗氧化、提升紧致和滋养的妇科凝胶的制备方法,其特征在于,所述第五步中稳定剂包括羟丙基甲基纤维素、聚丙烯酸钠和聚乙烯吡咯烷酮。
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