CN116831942A - Lysozyme-containing toothpaste and preparation method thereof - Google Patents
Lysozyme-containing toothpaste and preparation method thereof Download PDFInfo
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- CN116831942A CN116831942A CN202311051092.1A CN202311051092A CN116831942A CN 116831942 A CN116831942 A CN 116831942A CN 202311051092 A CN202311051092 A CN 202311051092A CN 116831942 A CN116831942 A CN 116831942A
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- 108010014251 Muramidase Proteins 0.000 title claims abstract description 69
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- 230000000694 effects Effects 0.000 abstract description 19
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 abstract description 15
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- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 4
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- 241000588724 Escherichia coli Species 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 3
- 238000005187 foaming Methods 0.000 description 3
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- 238000012360 testing method Methods 0.000 description 3
- 241000220479 Acacia Species 0.000 description 2
- 241000605862 Porphyromonas gingivalis Species 0.000 description 2
- 241000194019 Streptococcus mutans Species 0.000 description 2
- 238000004061 bleaching Methods 0.000 description 2
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- 208000002064 Dental Plaque Diseases 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 229920000057 Mannan Polymers 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- MNLRQHMNZILYPY-MDMHTWEWSA-N N-acetyl-alpha-D-muramic acid Chemical compound OC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O)[C@@H]1NC(C)=O MNLRQHMNZILYPY-MDMHTWEWSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
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- 244000052616 bacterial pathogen Species 0.000 description 1
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- QVZZPLDJERFENQ-NKTUOASPSA-N bassianolide Chemical compound CC(C)C[C@@H]1N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C(C)C)OC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C(C)C)OC1=O QVZZPLDJERFENQ-NKTUOASPSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/882—Mixing prior to application
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a lysozyme-containing toothpaste, which comprises a first paste body and a second paste body which are separated, wherein the first paste body comprises the following components: 20 to 30 percent of humectant, 20 to 25 percent of friction agent, 1 to 2 percent of thickening agent, 0.5 to 1 percent of foaming agent, 0.05 to 0.1 percent of flavoring agent and the balance of water; wherein the foaming agent comprises the following components in percentage by weight: 5-10 of sodium dodecyl sulfate and dodecyl glucoside; the second paste comprises: 0.05 to 0.5 percent of lysozyme, 20 to 30 percent of humectant, 20 to 25 percent of friction agent, 1 to 2 percent of thickening agent, 0.05 to 0.1 percent of flavoring agent and the balance of water; when the ointment is used, the first ointment and the second ointment are mixed for use. The invention has the beneficial effects of providing the toothpaste which can better maintain the activity of lysozyme and has better killing effect on oral bacteria.
Description
Technical Field
The invention relates to the field of toothpaste preparation. More particularly, the invention relates to a lysozyme-containing toothpaste and a preparation method thereof.
Background
Toothpastes are typically composed of humectants, abrasives, thickeners, foaming agents, flavoring agents, water, and other adjunct ingredients. Currently, in order to better prevent dental caries and ensure oral cavity safety and health, current researchers add lysozyme to toothpaste. Lysozyme is a muramidase enzyme capable of hydrolyzing mucopolysaccharide in pathogenic bacteria, mainly by breaking beta-1, 4 glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine in cell wall, resulting in cell wall rupture. The lysozyme can inhibit the growth of microorganisms, selectively dissolves the cell walls of target microorganisms to inactivate the microorganisms, and the mammals have no cell walls, so that the lysozyme has no damage to oral tissues, can effectively inhibit the formation of dental plaque, and has good effect on guaranteeing oral health. For example, patent application 201610085933.4 discloses a toothpaste containing lysozyme which by the addition of lysozyme can significantly control oral bacteria. However, in the currently studied toothpaste containing lysozyme, because the foaming agent used is usually an ionic surfactant, and lysozyme is often incompatible with the surfactant containing ionic components, the activity of lysozyme is greatly affected.
Disclosure of Invention
It is an object of the present invention to solve at least the above problems and to provide a lysozyme-containing toothpaste, which can alleviate inhibition of lysozyme by ionic components of Sodium Dodecyl Sulfate (SDS) by adding dodecyl glycoside as a nonionic surfactant, while the cooperation of dodecyl glycoside and SDS ensures foaming performance.
To achieve these objects and other advantages and in accordance with the purpose of the invention, there is provided a method for preparing a lysozyme-containing toothpaste, comprising separate first and second pastes;
the first paste comprises the following components in percentage by weight: 20 to 30 percent of humectant, 20 to 25 percent of friction agent, 1 to 2 percent of thickening agent, 0.5 to 1 percent of foaming agent, 0.05 to 0.1 percent of flavoring agent and the balance of water; wherein the foaming agent comprises the following components in percentage by weight: 5-10 of sodium dodecyl sulfate and dodecyl glucoside;
the second paste comprises the following components in percentage by weight: 0.05 to 0.5 percent of lysozyme, 20 to 30 percent of humectant, 20 to 25 percent of friction agent, 1 to 2 percent of thickening agent, 0.05 to 0.1 percent of flavoring agent and the balance of water;
when the ointment is used, the first ointment and the second ointment are mixed for use.
Preferably, the thickener of the first paste is konjac gum, the thickener of the second paste is one of gelatin, acacia and xanthan gum, and the second paste further comprises 0.05-0.1% of beta-mannase by weight.
Preferably, the second paste further comprises 0.05-0.1% of glucose oxidase by weight.
Preferably, the humectant is one of glycerin, propylene glycol and polyethylene glycol.
Preferably, the friction agent is one of silicon dioxide and calcium carbonate.
Preferably, the flavoring agent is one of stevioside, saccharin sodium and aspartame.
Preferably, the weight ratio of the first paste to the second paste is 10:0.5 to 1.
The preparation method of the lysozyme-containing toothpaste is prepared from the following components of the lysozyme-containing toothpaste, and specifically comprises the following steps:
s1, preparing a first paste: mixing flavoring agent and water, stirring, adding humectant, stirring to obtain a first mixture, adding friction agent, thickener, foaming agent into the first mixture, and stirring to obtain the final product;
s2, preparing a second paste: mixing flavoring agent and water, stirring, adding humectant, stirring to obtain second mixture, adding friction agent, thickener, and lysozyme into the second mixture, and stirring.
The invention at least comprises the following beneficial effects:
firstly, dodecyl glucoside is used as a nonionic surfactant, so that the inhibition of ionic components of Sodium Dodecyl Sulfate (SDS) on lysozyme can be reduced, and meanwhile, the foaming performance is ensured by the cooperation of the dodecyl glucoside and the SDS;
and secondly, the konjak gum, the beta-mannase and the glucose oxidase are separated and packaged, the konjak gum is used as a thickening agent in packaging to play a role in bonding and shaping, and when the konjak gum is mixed and used, the beta-mannase can be used for enzymolysis of the konjak gum, on one hand, the overall viscosity of the toothpaste is reduced during tooth brushing, the inhibition of the viscosity of the toothpaste on the activity of lysozyme is lightened, on the other hand, glucose, mannose and konjak oligosaccharide are generated through enzymolysis, the oligosaccharide has an anti-inflammatory effect, the glucose can be oxidized into hydrogen peroxide by the glucose oxidase, and the hydrogen peroxide has a whitening effect, so that the tooth whitening effect can be improved.
Additional advantages, objects, and features of the invention will be set forth in part in the description which follows and in part will become apparent to those having ordinary skill in the art upon examination of the following or may be learned from practice of the invention.
Detailed Description
The present invention is described in further detail below with reference to examples to enable those skilled in the art to practice the same by referring to the description.
The invention provides a lysozyme-containing toothpaste, which comprises a first paste and a second paste which are separated;
the first paste comprises the following components in percentage by weight: 20 to 30 percent of humectant, 20 to 25 percent of friction agent, 1 to 2 percent of thickening agent, 0.5 to 1 percent of foaming agent, 0.05 to 0.1 percent of flavoring agent and the balance of water; wherein the foaming agent comprises the following components in percentage by weight: 5-10 of sodium dodecyl sulfate and dodecyl glucoside;
the second paste comprises the following components in percentage by weight: 0.05 to 0.5 percent of lysozyme, 20 to 30 percent of humectant, 20 to 25 percent of friction agent, 1 to 2 percent of thickening agent, 0.05 to 0.1 percent of flavoring agent and the balance of water;
when the paste is used, the first paste and the second paste are mixed for use;
in the above technical solution, the existing toothpaste containing device may be used to contain the first paste and the second paste, for example, a dual-cavity toothpaste tube disclosed in application number 201920570018.3, a dual-tube toothpaste tube disclosed in application number 200620057316.5, etc. may be used, and the existing toothpaste containing device may be used to separate the first paste from the second paste, so that the first paste and the second paste are synchronously extruded onto the toothbrush during use;
by adopting the technical scheme, the beneficial effects are that the inhibition of ionic components of Sodium Dodecyl Sulfate (SDS) on lysozyme can be lightened by adding dodecyl glycoside and dodecyl glycoside as nonionic surfactant, and meanwhile, the foaming performance is ensured by the cooperation of the dodecyl glycoside and the SDS.
In another technical scheme, the thickener of the first paste is konjac glucomannan, the thickener of the second paste is one of gelatin, acacia and xanthan gum, and the second paste also comprises 0.05-0.1% of beta-mannanase by weight percent; in the technical scheme, when in use, the first paste and the second paste can be extruded and mixed in advance (for example, 3-8 hours in advance) in a container such as a toothpaste cover or a cup according to actual conditions, so that beta-mannans are fully hydrolyzed into konjak gum to generate glucose, mannose and konjak oligosaccharide; by adopting the technical scheme, the method has the beneficial effects that the konjak gum is taken as the thickener of the first paste, and meanwhile, the beta-mannase is added into the second paste, so that the konjak gum is hydrolyzed by the beta-mannase to form glucose, mannose and konjak oligosaccharide, on one hand, the beta-mannase is used for hydrolyzing the konjak gum, the viscosity of the whole toothpaste is reduced, the influence of the whole viscosity of the toothpaste on the lysozyme activity can be reduced, and on the other hand, the konjak oligosaccharide has an inhibiting effect on bacteria such as escherichia coli and the like, and can further prevent and treat oral bacteria.
In another technical scheme, the second paste further comprises glucose oxidase with the weight percentage of 0.05-0.1%; in the technical scheme, the hydrogen peroxide is directly added into the traditional toothpaste, the hydrogen peroxide has a bleaching effect, teeth can be whitened, but the hydrogen peroxide can be naturally decomposed to generate water and oxygen in a long-term storage process, so that the whitening effect is lost; by adopting the technical scheme, the beneficial effects are that glucose generated by the decomposition of konjak gum can be further degraded by adding glucose oxidase, hydrogen peroxide is generated, the hydrogen peroxide has a bleaching effect, teeth can be whitened, and compared with the traditional toothpaste directly added with hydrogen peroxide, the toothpaste can be instantly used for generating hydrogen peroxide, so that the whitening effect is ensured.
In another technical scheme, the humectant is one of glycerin, propylene glycol and polyethylene glycol; by adopting the technical scheme, the obtained beneficial effects are that the glycerol, the propylene glycol and the polyethylene glycol are convenient to obtain and good in moisturizing effect.
In another technical scheme, the friction agent is one of silicon dioxide and calcium carbonate; by adopting the technical scheme, the obtained beneficial effects are that silicon dioxide and calcium carbonate are common friction agents, so that the friction agent is convenient to purchase and good in friction effect.
In another technical scheme, the flavoring agent is one of stevioside, saccharin sodium and aspartame; by adopting the technical scheme, the obtained beneficial effects are that the stevioside, the saccharin sodium and the aspartame are common sweeteners, and the materials are convenient to obtain and the use is safe.
In another technical scheme, the weight ratio of the first paste to the second paste is 10:0.5 to 1; in the above technical solution, the weight ratio of the first paste and the second paste refers to the filling weight ratio of the toothpaste containing device; by adopting the technical scheme, the obtained beneficial effect is that the weight ratio of the first paste to the second paste is designed to be 10:0.5 to 1, which is designed according to the actual situation, ensures the coordination of the addition amount of each component, simultaneously ensures the weight of the konjak gum of the first paste as much as possible, promotes the generation of more glucose and konjak oligosaccharide, and finally generates more hydrogen peroxide.
Example 1 ]
The invention provides a lysozyme-containing toothpaste, which comprises a first paste and a second paste which are separated;
the first paste comprises the following components in percentage by weight: 20% of glycerol, 20% of silicon dioxide, 1% of sodium carboxymethylcellulose, 0.5% of foaming agent, 0.05% of aspartame and the balance of water; wherein the foaming agent comprises the following components in percentage by weight: 5, compounding sodium dodecyl sulfate and dodecyl glucoside;
the second paste comprises the following components in percentage by weight: 0.05% of lysozyme, 20% of glycerol, 20% of silicon dioxide, 1% of sodium carboxymethylcellulose, 0.05% of aspartame and the balance of water;
preparation of lysozyme-containing toothpaste:
s1, preparing a first paste: mixing aspartame and water, stirring uniformly, adding glycerol, stirring uniformly to obtain a first mixture, and finally adding silicon dioxide, sodium carboxymethylcellulose, sodium dodecyl sulfate and dodecyl glucoside into the first mixture, and stirring uniformly to obtain the aspartame;
s2, preparing a second paste: mixing aspartame and water, stirring uniformly, adding glycerol, stirring uniformly to obtain a second mixture, and finally adding silicon dioxide, sodium carboxymethylcellulose and lysozyme into the second mixture, and stirring uniformly to obtain the aspartame;
when in use, the first paste and the second paste are mixed to obtain toothpaste to be used; wherein, the weight ratio of the first paste to the second paste is 10:1.
example 2 ]
The invention provides a lysozyme-containing toothpaste, which comprises a first paste and a second paste which are separated;
the first paste comprises the following components in percentage by weight: 25% of propylene glycol, 25% of calcium carbonate, 2% of xanthan gum, 1% of foaming agent, 0.1% of saccharin sodium and the balance of water; wherein the foaming agent comprises the following components in percentage by weight: 10 and dodecyl glucoside;
the second paste comprises the following components in percentage by weight: lysozyme 0.5%, propylene glycol 250%, calcium carbonate 25%, xanthan gum 1%, saccharin sodium 0.05%, and the balance water;
preparation of lysozyme-containing toothpaste:
s1, preparing a first paste: mixing saccharin sodium and water, stirring uniformly, adding propylene glycol, stirring uniformly to obtain a first mixture, and finally adding calcium carbonate, xanthan gum, sodium dodecyl sulfate and dodecyl glucoside into the first mixture, and stirring uniformly to obtain the final product;
s2, preparing a second paste: mixing aspartame and water, stirring uniformly, adding propylene glycol, stirring uniformly to obtain a second mixture, adding calcium carbonate, xanthan gum and lysozyme into the second mixture, and stirring uniformly to obtain the final product.
When in use, the first paste and the second paste are mixed to obtain toothpaste to be used; wherein, the weight ratio of the first paste to the second paste is 10:1.
example 3 ]
The invention provides a lysozyme-containing toothpaste, which comprises a first paste and a second paste which are separated;
the first paste comprises the following components in percentage by weight: 20% of glycerin, 20% of silicon dioxide, 1% of konjac glucomannan, 0.5% of foaming agent, 0.05% of stevioside and the balance of water; wherein the foaming agent comprises the following components in percentage by weight: 5, compounding sodium dodecyl sulfate and dodecyl glucoside;
the second paste comprises the following components in percentage by weight: 0.05% of lysozyme, 20% of glycerol, 20% of silicon dioxide, 1% of xanthan gum, 0.05% of stevioside, 0.05% of beta-mannase and the balance of water;
preparation of lysozyme-containing toothpaste:
s1, preparing a first paste: mixing stevioside and water, stirring uniformly, adding glycerol, stirring uniformly to obtain a first mixture, and finally adding silicon dioxide, konjac glucomannan, sodium dodecyl sulfate and dodecyl glucoside into the first mixture, and stirring uniformly to obtain the stevioside-water mixed material;
s2, preparing a second paste: mixing stevioside with water, stirring uniformly, adding glycerol, stirring uniformly to obtain a second mixture, and finally adding silicon dioxide, xanthan gum, lysozyme and beta-mannanase into the second mixture, and stirring uniformly to obtain the stevioside-containing compound;
before use, the first paste and the second paste are mixed uniformly in advance for 8 hours to obtain toothpaste to be used; wherein, the weight ratio of the first paste to the second paste is 10:1.
example 4 ]
The invention provides a lysozyme-containing toothpaste, which comprises a first paste and a second paste which are separated;
the first paste comprises the following components in percentage by weight: 20% of glycerin, 20% of silicon dioxide, 1% of konjac glucomannan, 0.5% of foaming agent, 0.05% of stevioside and the balance of water; wherein the foaming agent comprises the following components in percentage by weight: 5, compounding sodium dodecyl sulfate and dodecyl glucoside;
the second paste comprises the following components in percentage by weight: 0.05% of lysozyme, 20% of glycerol, 20% of silicon dioxide, 1% of xanthan gum, 0.05% of stevioside, 0.05% of beta-mannase, 0.05% of glucose oxidase and the balance of water;
preparation of lysozyme-containing toothpaste:
s1, preparing a first paste: mixing stevioside and water, stirring uniformly, adding glycerol, stirring uniformly to obtain a first mixture, and finally adding silicon dioxide, konjac glucomannan, sodium dodecyl sulfate and dodecyl glucoside into the first mixture, and stirring uniformly to obtain the stevioside-water mixed material;
s2, preparing a second paste: mixing stevioside with water, stirring, adding glycerol, stirring to obtain a second mixture, adding silicon dioxide, xanthan gum, lysozyme, beta-mannase and glucose oxidase into the second mixture, and stirring to obtain the final product.
Before use, the first paste and the second paste are mixed uniformly in advance for 8 hours to obtain toothpaste to be used; wherein, the weight ratio of the first paste to the second paste is 10:1.
comparative example 1 ]
The difference from example 1 is that sodium dodecyl sulfate was used instead of dodecyl glycoside in the first paste, and the other is the same as example 1.
Comparative example 2 ]
In this comparative example, the toothpaste formulation was as follows:
20 parts of glycerol, 20 parts of silicon dioxide, 1 part of sodium carboxymethyl cellulose, 0.5 part of foaming agent, 0.05 part of aspartame, 0.05 part of lysozyme and the balance of water; the foaming agent comprises the following components in percentage by weight: 5, compounding sodium dodecyl sulfate and dodecyl glucoside;
the preparation method comprises the following steps: mixing aspartame and water, stirring uniformly, adding glycerol, stirring uniformly to obtain a first mixture, and finally adding lysozyme, silicon dioxide, carboxymethyl cellulose, sodium dodecyl sulfate and dodecyl glucoside into the first mixture, and stirring uniformly to obtain the toothpaste to be used.
< antibacterial Effect >
The method comprises the following steps: the antibacterial effect of the toothpastes in examples 1 to 4 and comparative examples 1 to 2 was evaluated according to 7.3 in QB/T2738-2012 evaluation method of antibacterial and bacteriostatic effect of daily chemical products, taking the inhibition ratio of E.coli, porphyromonas gingivalis and Streptococcus mutans as an index of investigation.
Sample: the toothpaste to be used in examples 1 to 4 and comparative examples 1 to 2 was used for measuring the antibacterial rate, and the specific results are shown in Table 1;
TABLE 1 antibacterial Effect of toothpastes to be used in examples 1 to 4 and comparative examples 1 to 2
As can be seen from Table 1, the toothpaste prepared by the formula and the method of the invention has good inhibition effect on escherichia coli, porphyromonas gingivalis and streptococcus mutans, because the existing ionic surfactant is easy to combine with lysozyme so as to influence the activity of the lysozyme, when the surfactant and the lysozyme in the toothpaste are separately placed and the ionic surfactant and the nonionic surfactant are compounded for use, the inhibition of the ionic surfactant on the activity of the lysozyme can be effectively removed, and the killing effect of the ionic surfactant on oral bacteria can be effectively ensured.
< measurement of lysozyme Activity >
The method comprises the following steps: GB/T25879-2010;
sample: the first paste and the second paste of examples 1 to 4 and comparative example 1, and the toothpaste of comparative example 2 were left at 4℃and 45℃for 3 months, respectively, and then the lysozyme activity was measured; wherein, the first paste and the second paste are mixed for 8 hours in advance before the measurement in examples 2-4, and then the lysozyme activity is measured, and the specific results are shown in Table 2;
TABLE 2 measurement results of lysozyme Activity in toothpastes of examples 1 to 4 and comparative examples 1 to 2
As can be seen from Table 2, the toothpaste prepared by the formula and the method of the invention can effectively ensure the activity of lysozyme, on one hand, by designing dodecyl glycoside and dodecyl glycoside as nonionic surfactant, the inhibition of ionic components of Sodium Dodecyl Sulfate (SDS) on lysozyme can be relieved, and on the other hand, the inhibition of ionic components on lysozyme activity is relieved, and on the other hand, the separately packaged konjak gum, beta-mannanase and glucose oxidase are designed as a thickening agent, so that the adhesive shaping effect is achieved, and the beta-mannanase can be used for enzymolysis of konjak gum, on the one hand, the konjak gum can be reduced during tooth brushing, and further the overall viscosity of the paste can be reduced, and the inhibition of paste viscosity on lysozyme activity can be relieved.
< measurement of stain index >
The method comprises the following steps: 120 volunteers (subjects) with extrinsic stains in the age range 25-55 years were selected and divided into six groups of 20 persons each. Each subject uniformly distributes toothpaste and toothbrush, and brushes teeth 1 time in the morning and evening for 2 times each time for 1min according to the BASS brushing method. Clinical examination was performed at baseline, fourth week and eighth week, with statistical analysis using t-test, double-sided test, test level α of 0.05; wherein, the tooth stain is evaluated by adopting a Lobene (Lobene stain index method) stain index, the size of the stain part and the degree of the stain are evaluated by using numbers of 0 to 3, and the specific scoring standard is shown in Table 3;
sample: toothpaste to be used in examples 1 to 4 and comparative examples 1 to 2 were taken and tested, wherein examples 1 to 4 and comparative examples 1 to 2 correspond to the six groups of subjects described above, respectively, and specific results are shown in table 4;
TABLE 3 tooth stain scoring criteria
Table 4 test results of tooth stain index of the subjects of examples 1 to 4 and comparative examples 1 to 2
| Experimental example | Base line | Fourth periphery | Eighth week |
| Example 1 | 2.87±1.04 | 2.58±0.87 | 2.46±1.37 |
| Example 2 | 2.79±1.12 | 2.56±1.35 | 2.44±0.94 |
| Example 3 | 2.92±1.33 | 2.47±1.84 | 2.34±1.22 |
| Example 4 | 2.83±0.97 | 2.15±1.25 | 1.43±1.06 |
| Comparative example 1 | 2.91±1.54 | 2.55±0.93 | 2.46±1.57 |
| Comparative example 2 | 2.85±1.62 | 2.60±1.52 | 2.48±1.33 |
As can be seen from table 4, the toothpaste prepared in example 4 has a better whitening effect on extrinsic stains because in example 4, glucose oxidase is used, and when beta-mannanase enzyme hydrolyzes konjac gum, konjac gum is enzymatically hydrolyzed to form glucose, mannose and konjac oligosaccharides, further, glucose can be oxidized to hydrogen peroxide by the glucose oxidase, and the hydrogen peroxide has a whitening effect, and tooth whitening effect can be improved.
In conclusion, the toothpaste prepared by the invention has good antibacterial effect and tooth whitening effect, and has good application prospect.
Although embodiments of the present invention have been disclosed above, it is not limited to the details and embodiments shown, it is well suited to various fields of use for which the invention is suited, and further modifications may be readily made by one skilled in the art, and the invention is therefore not to be limited to the particular details and examples shown and described herein, without departing from the general concepts defined by the claims and the equivalents thereof.
Claims (8)
1. A lysozyme-containing toothpaste comprising a first paste and a second paste that are separate;
the first paste comprises the following components in percentage by weight: 20 to 30 percent of humectant, 20 to 25 percent of friction agent, 1 to 2 percent of thickening agent, 0.5 to 1 percent of foaming agent, 0.05 to 0.1 percent of flavoring agent and the balance of water; wherein the foaming agent comprises the following components in percentage by weight: 5 to 10 of sodium dodecyl sulfate and dodecyl glycoside are compounded;
the second paste comprises the following components in percentage by weight: 0.05 to 0.5 percent of lysozyme, 20 to 30 percent of humectant, 20 to 25 percent of friction agent, 1 to 2 percent of thickening agent, 0.05 to 0.1 percent of flavoring agent and the balance of water;
when the ointment is used, the first ointment and the second ointment are mixed for use.
2. The lysozyme-containing toothpaste according to claim 1, wherein the thickener of the first paste is konjac gum, the thickener of the second paste is one of gelatin, acacia and xanthan gum, and the second paste further comprises 0.05-0.1% by weight of beta-mannanase.
3. The lysozyme-containing toothpaste according to claim 2, wherein said second paste further comprises 0.05 to 0.1% by weight of glucose oxidase.
4. The lysozyme-containing dentifrice of claim 1 wherein said humectant is one of glycerin, propylene glycol, polyethylene glycol.
5. The lysozyme-containing dentifrice of claim 1 wherein said abrasive is one of silica and calcium carbonate.
6. The lysozyme-containing dentifrice of claim 1 wherein said flavoring agent is one of stevioside, sodium saccharin, aspartame.
7. The lysozyme-containing toothpaste according to claim 1, characterized in that the weight ratio of said first paste to said second paste is 10:0.5 to 1.
8. A method for preparing a lysozyme-containing dentifrice according to any one of claims 1 to 7, comprising the steps of:
s1, preparing a first paste: mixing flavoring agent and water, stirring, adding humectant, stirring to obtain a first mixture, adding friction agent, thickener, foaming agent into the first mixture, and stirring to obtain the final product;
s2, preparing a second paste: mixing flavoring agent and water, stirring, adding humectant, stirring to obtain second mixture, adding friction agent, thickener, and lysozyme into the second mixture, and stirring.
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