CN116831724A - Excimer laser ablation catheter - Google Patents
Excimer laser ablation catheter Download PDFInfo
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- CN116831724A CN116831724A CN202310904856.0A CN202310904856A CN116831724A CN 116831724 A CN116831724 A CN 116831724A CN 202310904856 A CN202310904856 A CN 202310904856A CN 116831724 A CN116831724 A CN 116831724A
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- excimer laser
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- inner cavity
- pipe
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- A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
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- Optics & Photonics (AREA)
- Laser Surgery Devices (AREA)
Abstract
The application relates to an excimer laser ablation catheter, which relates to the field of optical fiber interventional catheters, and comprises a laser joint, an optical fiber catheter, a branch connector, an interventional catheter and an excimer laser fiber, wherein the laser joint, the optical fiber catheter, the branch connector and the interventional catheter are sequentially connected, the excimer laser fiber extends from the laser joint to the head end of the interventional catheter through the optical fiber catheter and the branch connector, an inner cavity tube is arranged in the interventional catheter, one end of the inner cavity tube is communicated with the branch connector, the other end of the inner cavity tube is opened at the head end of the interventional catheter, the inner cavity tube is made of polytetrafluoroethylene materials, a connecting ring is crimped outside the head end of the inner cavity tube, and the head end connection of the excimer laser fiber is in sealing connection with the connecting ring and the wall part of the interventional catheter, so that the adhesion of foreign matters in the inner cavity tube can be reduced, and the inner cavity tube is convenient to clean.
Description
Technical Field
The application relates to the field of optical fiber interventional catheters, in particular to an excimer laser ablation catheter.
Background
Excimer laser refers to laser light generated by exciting a dimer, and usually, a mixed gas of an inert gas and a halogen gas is excited by an electron beam to form a dimer molecule, and the dimer molecule transitions to its ground state to generate excimer laser light. The excimer laser acts on biological tissue to produce not thermal effect, but photochemical reaction, that is, when the laser irradiates the organism tissue, the bond between tissue molecules is broken, the tissue is separated into volatile fragments for dissipation, and the surrounding tissue is not affected. Excimer lasers are increasingly used in cornea refractive surgery, cardiovascular disease treatment, and dermatological treatment.
In the treatment of cardiovascular diseases using excimer lasers, an excimer laser ablation catheter is typically inserted percutaneously into a blood vessel, and the tip of the excimer laser ablation catheter is inserted into the lesion to be treated. The excimer laser generated by the laser is guided by the excimer laser ablation catheter and irradiates the lesion part of the heart or the blood vessel to perform ablation treatment on the lesion part. An inner cavity tube is arranged in the excimer laser ablation catheter, and can be used for injecting liquid medicine or developer into the heart and blood vessels, so that the treatment and observation effects of lesion sites are improved.
The inner cavity tube of the existing excimer laser ablation catheter is usually made of polyvinyl chloride and other materials, and after external substances enter the inner cavity tube, the external substances are easy to adhere to the wall part of the inner cavity tube, and the inner diameter of the inner cavity tube is smaller, so that the cleaning difficulty is higher. And the adherends enter the blood vessel of the human body in the treatment process, so that great hidden dangers affecting the health of the human body can be formed.
Disclosure of Invention
In order to reduce the adhesion of foreign matters in an inner cavity tube and facilitate the cleaning of the inner cavity tube, the application provides an excimer laser ablation catheter.
The excimer laser ablation catheter provided by the application adopts the following technical scheme:
the utility model provides an excimer laser ablation pipe, includes laser joint, optic fibre pipe, branch connector, intervenes pipe and excimer laser fiber, laser joint, optic fibre pipe, branch connector and intervene the pipe and link to each other in proper order, excimer laser fiber by laser joint warp optic fibre pipe and branch connector extend to intervene the head end of pipe, intervene the inside of pipe is provided with the inner chamber pipe, the one end of inner chamber pipe with branch connector is linked together, the other end opening in intervene the head end of pipe, the inner chamber pipe is made by polytetrafluoroethylene material, the head end outside crimping of inner chamber pipe has the go-between, excimer laser fiber the head end with intervene the wall sealing connection of pipe.
By adopting the technical scheme, the inner cavity tube made of polytetrafluoroethylene material can reduce the adhesion of foreign matters on the tube wall, and is convenient for cleaning the foreign matters in the inner cavity tube; the end of the excimer laser fiber can be reliably connected between the inner cavity tube and the tube wall of the interventional catheter by using the connecting ring arranged at the head end of the inner cavity tube, so that the sealing of the head end of the interventional catheter is formed, and the defect that polytetrafluoroethylene materials are not easy to adhere and the end sealing is difficult to ensure is overcome; the connecting ring is used for being pressed and connected with the outer side of the head end of the inner cavity pipe, interference fit between the inner cavity pipe and the connecting ring can be formed, and reliable sealing between the inner cavity pipe and the connecting ring is formed by using elasticity of polytetrafluoroethylene materials.
In a specific embodiment, the inner lumen is located in the middle of the interventional catheter, and a plurality of excimer laser optical fibers are wrapped around the circumference of the inner lumen.
By adopting the technical scheme, the liquid medicine can be accurately conveyed by using the inner cavity tube arranged in the middle of the interventional catheter, and the heat dissipation performance of the peripheral excimer laser fiber can be improved; the excimer laser fiber is wrapped around the inner cavity tube, so that the uniformity of excimer laser emitted from the head end of the interventional catheter can be improved, and the laser ablation effect is improved.
In a specific embodiment, a plurality of the excimer laser optical fibers are layered around the perimeter of the inner lumen tube to form a plurality of concentric circles.
Through adopting above-mentioned technical scheme, utilize the excimer laser optic fibre of a plurality of concentric circles arrangements, can optimize the distribution range through intervention catheter head end outgoing excimer laser, form more even laser ablation effect.
In a specific embodiment, the connecting ring is made of a metal material and is secured to the head end of the inner lumen tube by a spinning process.
By adopting the technical scheme, the diameter of the connecting ring can be uniformly reduced by utilizing the ductility and the compressibility of the metal material through a spinning process, and the periphery of the tube wall of the inner cavity tube is uniformly extruded, so that the connecting ring can be reliably nested on the tube wall of the inner cavity tube, and reliable connection and sealing between the connecting ring and the inner cavity tube are formed. The metal material can also adhere to the adhesive better to form an adhesive seal with the excimer laser fiber.
In a specific embodiment, the outer wall of the connecting ring is flush with the outer wall adjacent the lumen tube.
Through adopting above-mentioned technical scheme, utilize the outer wall of go-between and the setting of adjacent inner chamber pipe outer wall parallel and level, can improve the inboard roughness of excimer laser optic fibre, prevent that excimer laser optic fibre from producing to bend because of receiving the extrusion of go-between tip edge.
In a specific embodiment, the head end of the interventional catheter is further provided with a developing ring, and the developing ring is spliced at the head end of the sheath tube of the outer layer of the interventional catheter and is located outside the excimer laser fiber.
Through adopting above-mentioned technical scheme, utilize the development ring that sets up at the catheter head end of intervene, can clearly image in X-ray image, show the position of interventional catheter head end in blood vessel or heart, be convenient for accurately send interventional catheter head end to the pathological change position, carry out effectual laser ablation treatment to the pathological change position.
In a specific embodiment, the developing ring is made of tantalum alloy, or platinum iridium alloy.
By adopting the technical scheme, the high-quality density of tantalum, platinum and iridium can be used for blocking the passage of X-rays, so that a clear image can be better formed in an X-ray image; the ultra-high corrosion resistance of tantalum, platinum and iridium is utilized, so that the corrosion of the developing ring in the storage and use processes can be prevented, and the stimulation of the excimer laser ablation catheter to human tissues is reduced.
In a specific embodiment, the end face of the head end of the interventional catheter protrudes outwards, and the head end of the excimer laser optical fiber is located on the protruding face.
Through adopting above-mentioned technical scheme, utilize to outside convex intervention pipe's terminal surface, can make the excimer laser that jets out through excimer laser optic fibre to the outside of side direction diverge, enlarge excimer laser's irradiation range, improve the ablation effect to organism tissue.
In a specific embodiment, the end face of the head end of the interventional catheter comprises a plane located in the middle of the end face and a convex curved surface located at the periphery, the head end of the inner cavity tube is located on the plane, and the head end of the excimer laser optical fiber is located on the convex curved surface.
By adopting the technical scheme, the stability of the flow direction of the liquid medicine input through the inner cavity tube can be improved by utilizing the arrangement that the head end of the inner cavity tube is positioned on the plane, and the stimulation of the end edge of the inner cavity tube to the machine body is reduced; the arrangement that the head end of the excimer laser fiber is positioned on the convex curved surface is utilized to ensure the diffusivity of the excimer laser emitted by the excimer laser fiber.
In a specific embodiment, the end surface of the head end of the interventional catheter is a spherical surface protruding outwards.
Through adopting above-mentioned technical scheme, utilize the terminal surface of intervention pipe head end to wholly form the setting of outwards convex curved surface, the processing shaping of the terminal surface of intervention pipe head end of being convenient for, the curved surface of spherical can form the more even extension irradiation range of excimer laser.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the inner cavity tube made of polytetrafluoroethylene material can improve the chemical stability, high lubrication non-tackiness and ageing resistance of the inner cavity tube, prevent foreign matters from adhering to the wall of the inner cavity tube, improve the cleaning effect of the inner cavity tube cavity, reduce the irritation of the inner cavity tube material to organism tissues and ensure the service life of the inner cavity tube;
2. the connecting ring is in compression joint with the inner cavity pipe to form interference fit connection between the connecting ring and the inner cavity pipe, and the reliable seal between the inner cavity pipe and the connecting ring is formed by using the elasticity of polytetrafluoroethylene material, so that the pollution and corrosion of the excimer laser ablation catheter caused by the penetration of body fluid into the intervention catheter outside the inner cavity pipe are prevented;
3. the connection between the excimer laser optical fiber and the connecting ring is utilized, and the sealing connection between the head end of the excimer laser optical fiber and the inner cavity tube can be formed by means of the connecting ring, so that the defect that the polytetrafluoroethylene material cannot form sealing connection with the excimer laser optical fiber due to the fact that the polytetrafluoroethylene material is insoluble in any solvent and does not adhere to any substance is overcome, and the reliable sealing of the head end of the interventional catheter is ensured through the arrangement of the connecting ring.
Drawings
FIG. 1 is a schematic view of one embodiment of an excimer laser ablation catheter of the present application.
FIG. 2 is a schematic cross-sectional view of a portion of an excimer laser ablation catheter according to one embodiment of the present application in the head end of the insertion catheter.
FIG. 3 is a schematic diagram of an excimer laser optical fiber arrangement in another embodiment of an excimer laser ablation catheter according to the present application.
FIG. 4 is a schematic diagram showing the state of the connecting ring before spinning in one embodiment of the excimer laser ablation catheter of the present application.
FIG. 5 is a schematic illustration of a state of the connecting ring after spinning in an embodiment of the excimer laser ablation catheter of the present application.
Fig. 6 is a longitudinal cross-sectional view of a portion of an excimer laser ablation catheter according to one embodiment of the present application, the portion being the leading end of the insertion catheter.
Fig. 7 is a longitudinal cross-sectional view of a portion of an end of an insertion catheter in accordance with another embodiment of the excimer laser ablation catheter of the present application.
Reference numerals illustrate: 1. a laser joint; 2. an optical fiber catheter; 3. a branch connector; 4. an interventional catheter; 41. an inner lumen tube; 42. a connecting ring; 43. a developing ring; 44. a sheath tube; 5. an excimer laser fiber.
Detailed Description
The following describes specific embodiments of the present application in detail with reference to the drawings. It should be understood that the detailed description and specific examples, while indicating and illustrating the application, are not intended to limit the application.
In the description of the present application, it should be noted that, unless explicitly stated and limited otherwise, the terms "disposed" and "connected" should be interpreted broadly, and for example, they may be fixedly connected, detachably connected, or integrally connected; either directly or indirectly via an intermediate medium, or in communication with each other or in interaction with each other. The specific meaning of the above terms in the present application can be understood by those of ordinary skill in the art according to the specific circumstances.
An embodiment of the excimer laser ablation catheter of the present application, as shown in fig. 1 and 2, comprises a laser connector 1, a fiber catheter 2, a branch connector 3, an interventional catheter 4 and an excimer laser fiber 5. The laser joint 1, the optical fiber conduit 2, the branch connector 3 and the intervention conduit 4 are connected with each other in sequence, the excimer laser optical fiber 5 extends out of the laser joint 1, enters the intervention conduit 4 after passing through the optical fiber conduit 2 and the branch connector 3, and is connected to the end face of the head end of the intervention conduit 4.
The interventional catheter 4 is used for being inserted into a blood vessel of a human body, and guiding an excimer laser optical fiber 5 to a lesion site in the heart and the blood vessel. The outer circumference of the interventional catheter 4 is usually provided with a sheath tube 44 made of medical rubber, the sheath tube 44 being able to protect the inner excimer laser optical fiber 5 and to maintain a certain flexibility for passing through long and tortuous vessels. The interventional catheter 4 may be used in a variety of different diameters depending on the lesion.
The interventional catheter 4 is internally provided with a lumen tube 41, the lumen tube 41 being made of Polytetrafluoroethylene (PTFE) material for injecting a medicament, physiological saline, a contrast agent, or the like to a lesion of a heart, a blood vessel, or the like, as necessary. One end of the lumen tube 41 communicates with the branch connector 3, and the other end opens on the end face of the head end of the interventional catheter 4. A connection ring 42 is crimped to the outside of the head end of the inner tube 41. The attachment ring 42 may be made of a variety of metallic materials, typically corrosion resistant, high ductility metallic materials such as stainless steel, titanium alloys. The connecting ring 42 is fitted over the head end of the lumen tube 41, and the connecting ring 42 is deformed and contracted by applying pressure to the outside of the adhesive ring 42. The contracted connecting ring 42 extrudes the inner cavity tube 41, so that the tube wall material of the inner cavity tube 41 flows and deforms, the connecting ring 42 is tightly nested on the inner cavity tube 41, and firm connection and reliable sealing between the inner cavity tube 41 and the connecting ring 42 are formed by utilizing the elasticity of PTEF material.
Of course, plastic such as PVC, PE, PP may be used to form the connecting ring 42 on the inner tube 41 by compression molding or calendaring, so that the inner tube 41 is deformed and contracted under pressure by the molding and curing of the connecting ring 42 under pressure, and an interference fit connection between the inner tube 41 and the connecting ring 42 and a reliable seal therebetween can be formed after the pressure is removed.
The excimer laser fiber 5 passes through the outside of the lumen tube 41 and the inside of the sheath tube 44, and is configured to transmit excimer laser light to the head end of the interventional catheter 4, and to emit the excimer laser light from the end face of the head end, so as to ablate diseased tissue in the heart or blood vessel. The end of the excimer laser fiber 5 can be adhered between the connecting ring 42 and the end structure of the sheath tube 44 through medical adhesive, after the medical adhesive is cured, the connection among the excimer laser fiber 5, the metal ring 42 and the inner cavity tube 41 is formed, and the different structures at the end of the head end of the interventional catheter 4 are in sealing connection. Specifically, a suitable adhesive, sealant or coating such as medical epoxy may be applied to the perimeter of the excimer laser optical fiber 5 to form a connection and seal between the excimer laser optical fiber 5 and the connection ring 42 and the lumen tube 41.
The branch connector 3 is connected between the interventional catheter 4 and the optical fiber catheter 2, and comprises a connecting portion 31 and a branch interface 32 which are integrally connected with each other, and the branch interface 32 is connected with the lumen tube 41 through a connecting pipe provided inside the connecting portion 31. The inner tube 41 and the connecting part 31 can be connected in an interference fit manner, or the inner tube 41 can be used for extending to the opening of the branch interface 32. On the one hand, the branch connector 3 is of a hard structure which does not need to be bent, so that reliable interference fit with the inner cavity tube 41 is easier to form, leakage between the inner cavity tube 41 and the branch connector 3 is prevented, and on the other hand, the branch connector 3 is positioned outside a human body when in use, is not soaked in liquid, and leakage and pollution of the liquid are not easy to generate.
An elastic sleeve can be further arranged between the branch connector 3 and the interventional catheter 4, and the elastic sleeve can protect the connecting end of the interventional catheter 4 and the branch connector 3 and prevent the joint of the interventional catheter 4 from being excessively bent.
The excimer laser optical fiber 5 enters one end of the connection part 31 from the interventional catheter 4, and passes out from the other end of the connection part 31 into the optical fiber catheter 2.
An optical fiber conduit 2 is connected between the laser connector 1 and the branch connector 3 for receiving and protecting an excimer laser optical fiber 5. In use, the branch connector 3 is typically positioned at the patient's side for the medical personnel to perform the necessary operations, while the laser connector 1 is typically inserted onto the laser with a certain distance required to be maintained between the two, and the fiber optic catheter 2 is positioned to facilitate the excimer laser fiber 5 to traverse a longer distance and enter the interventional catheter 4.
The laser connection 1 is used in connection with a laser, or other connection to a laser, to direct excimer laser light generated by the laser into an excimer laser optical fiber 5. The laser connector 1 can be various standard commercial connectors or nonstandard connectors designed according to the existing connector principle according to the matched connector shape.
One end of the laser connector 1 is provided with an interface for transmitting excimer laser, and an excimer laser fiber 5 generally enters the interior of the laser connector 1 to be connected with the laser interface. A rubber sleeve is arranged at the joint of the laser connector 1 and the optical fiber conduit 2, and the rubber sleeve is sleeved outside the optical fiber conduit 2 to prevent the joint of the optical fiber conduit 2 from being excessively bent.
In order to ensure the light transmission performance of the end of the excimer laser optical fiber 5 and improve the laser transmission efficiency of the excimer laser optical fiber 5, when manufacturing an excimer laser ablation catheter, it is generally necessary to perform polishing processing on the end surface of the interventional catheter 4, and impurities formed by polishing the end surface of the interventional catheter 4 inevitably enter the lumen of the lumen tube 41. In the case of excimer laser ablation catheters, the interventional catheter 4 is inserted into a blood vessel of the human body, and the components of blood are also easily introduced into the lumen of the lumen tube 41. These tend to cause external foreign matters to adhere to the inner wall of the inner lumen tube 41, and the foreign matters adhered to the lumen of the inner lumen tube 41 once entering the blood vessel of the human body form a serious threat to the health of the human body.
The inner cavity tube of the common excimer laser ablation catheter is made of common medical plastics such as polyvinyl chloride, PE and the like, and foreign matters entering the lumen are easy to deposit and adhere on the wall of the inner cavity tube, so that the inner cavity tube needs to be cleaned. Because the pipe diameter of the inner cavity pipe is smaller, the inner cavity pipe can be cleaned only through water flow flushing or high-pressure air flow flushing, and the inner cavity pipe is more troublesome to clean and has poorer cleaning effect.
PTFE is a novel polymer plastic, is insoluble in any solvent, has extremely low surface tension, does not adhere to any substance, has the advantages of high chemical stability, strong corrosion resistance and high lubrication and is not adhered to the inner cavity tube 41, and the PTFE is used for manufacturing the inner cavity tube 41 and can effectively prevent the adhesion of foreign matters on the wall of the inner cavity tube 41, so that the foreign matters entering the inner cavity tube 41 can be easily cleaned and removed. However, because PTFE is insoluble in any solvent and does not adhere to any substance, the use of PTFE material for the inner lumen 41 makes it difficult for the head end of the inner lumen 41 to form a connection and seal with the excimer laser optical fiber 5 or other structures at the end of the interventional catheter 4. During use, cleaning or sterilization, external hydraulic pressure can easily enter the interior of the interventional catheter 4 structure through the gap outside the lumen tube 41, causing pollution of the interventional catheter 4, and seriously impeding the application of PTFE materials in various interventional catheters. The problem of foreign matter adhesion in the inner lumen tube 41 and the difficulty in cleaning are also problematic in the art.
The application forms reliable connection between the inner cavity tube 41 and the connecting ring 42 by crimping the connecting ring 42 at the head end of the inner cavity tube 41 made of PTFE material and by utilizing the compression deformation of the connecting ring 42 and the compression deformation of the head end of the inner cavity tube 41, forms reliable seal between the inner cavity tube 41 and the connecting ring 42 by interference fit between the inner cavity tube 41 and the connecting ring 42, and then forms reliable seal between the connecting ring 42 and the excimer laser optical fiber 5 by utilizing the connecting ring 42 to connect with the excimer laser optical fiber 5, thereby effectively solving the problems of connection and sealing between the inner cavity tube 41 made of PTFE material and the excimer laser optical fiber 5, ensuring the tightness of the head end of the interventional catheter 4, and further successfully solving the technical problems of foreign matter attachment and difficult cleaning in the inner cavity tube 41 by applying the inner cavity tube 41 to the excimer laser ablation catheter.
In a preferred embodiment of the excimer laser ablation catheter of the present application, as shown in fig. 2 and 3, inside the interventional catheter 4, the lumen tube 41 is provided in the middle of the interventional catheter 4, i.e. near the central axis of the interventional catheter 4. The interventional catheter 4 is provided with a plurality of excimer laser fibers 5, and the excimer laser fibers 5 are arranged around the inner lumen 41 in a peripheral region of the interventional catheter 4.
As a specific embodiment of the excimer laser ablation catheter of the present application, as shown in fig. 3, inside the interventional catheter 4, a plurality of excimer laser fibers 5 are arranged in layers around the inner lumen 41, and are arranged in 2-5 concentric circles around the inner lumen 41, forming an array of excimer laser fibers 5 arranged in a circle.
In some embodiments of the excimer laser ablation catheter of the present application, the attachment ring 42 is made of a metallic material, typically a metallic material such as stainless steel, titanium alloy, cobalt-based alloy, or the like. In the manufacturing process, as shown in fig. 4, a connecting ring 42 made of a metal material is sleeved at the head end of an inner cavity tube 41, and the outer periphery of the connecting ring 42 is spun by a spinning device, so that the connecting ring 42 is gradually contracted. The inner wall of the connecting ring 42 extrudes the inner cavity tube 41, so that PTFE material on the wall of the inner cavity tube 41 deforms and flows, the wall of the end part of the inner cavity tube 41 becomes thinner, and the connecting ring 42 also expands and becomes thinner. Thus, the attachment ring 42 is nested on the end of the inner lumen 41 by a spinning process, creating the connection between the attachment ring 42 and the inner lumen 41 as shown in FIG. 5. Wherein, the connecting ring 42 is covered on the outer periphery of the inner cavity tube 41 due to compression and shrinkage, the inner cavity tube 41 tightly abuts against the inner wall of the connecting ring 42 due to self elasticity, so as to form interference fit between the inner cavity tube 41 and the connecting ring 42, fix the connecting ring 42 at the head end of the inner cavity tube 41 and form reliable seal between the two.
As an embodiment of the excimer laser ablation catheter of the present application, as shown in fig. 5, the connecting ring 42 is deformed by spinning to gradually reduce the diameter, and the inner wall of the connecting ring 42 is pressed against the lumen tube. The outer diameter of the lumen tube 41 inside the connecting ring 42 is reduced by the pressing action of the connecting ring 42, and the reduction in the diameter of the connecting ring 42 makes the outer wall of the connecting ring 42 flush with the outer wall of the adjacent lumen tube 41. The connecting ring 42 is fixed on the inner cavity tube 41 through the spinning process, so that the inner diameter of the inner cavity tube 41 is not obviously reduced.
In some embodiments of the excimer laser ablation catheter of the present application, as shown in fig. 6 and 7, a developing ring 43 is provided at the head end of the interventional catheter 4. The developing ring 43 may be made of various materials capable of developing in an X-ray image, so that the image of the developing ring 43 can be observed by an X-ray imaging apparatus, thereby conveniently observing the position of the developing ring 43 in the blood vessel or heart of the human body, which represents the position of the head end of the interventional catheter 4 in the blood vessel or heart of the human body. This contributes to accurate irradiation of excimer laser light onto a lesion tissue in a blood vessel or heart, laser ablation of the lesion tissue, accurate delivery of a necessary drug or physiological saline to a lesion site, and improvement of the therapeutic effect of the lesion site.
A sheath tube 44 is arranged outside the interventional catheter 4, and the sheath tube 44 is coated on the outer layer of the excimer laser fiber 5 to form the protection of the excimer laser fiber 5. The developing ring 43 is sleeved at the head end of the interventional catheter 4, the sheath tube 44 replacing the head end is coated on the periphery of the excimer laser optical fiber 5, one side end surface of the developing ring 43 positioned at the end part of the interventional catheter 4 forms a part of the end surface of the interventional catheter 4, and the other side is spliced with the sheath tube 44, and specifically, the two end surfaces are connected through various possible connection modes such as adhesive connection and the like.
Compared with the traditional mode of sleeving the developing ring 43 on the outer side of the sheath tube 44 or sleeving the sheath tube 44 on the outer side of the developing ring 43, the mode of splicing the developing ring 43 and the sheath tube 44 can ensure the parallel and level of the developing ring 43 and the inner side wall and the outer side wall of the sheath tube 44, so that the excimer laser optical fiber 5 is prevented from being pressed and bent, the smoothness of the periphery of the interventional catheter 4 can be ensured, and the unimpeded passage of the interventional catheter 4 in a tiny blood vessel is facilitated.
In a preferred embodiment of the excimer laser ablation catheter of the present application, the developing ring 43 is made of tantalum alloy material, or platinum iridium alloy material. Tantalum is a transition metal with extremely high corrosion resistance, has higher density and better toughness, and can better block the passage of X-rays so as to be developed in X-ray images. Similarly, the platinum iridium alloy is a platinum-based iridium-containing binary alloy, comprises Ptlrl0, ptlr17.5, ptlr25, ptlr30 and other alloys, has the characteristics of high density, high melting point and high corrosion resistance, and can better block the passage of X rays. The developing ring 43 made of tantalum or platinum iridium alloy can be clearly developed in an X-ray image with a thinner ring thickness, so that it can be applied to an excimer laser ablation catheter with a smaller diameter.
In some embodiments of the excimer laser ablation catheter of the present application, as shown in fig. 6 and 7, the end face of the head end of the interventional catheter 4 is formed in a structure protruding to the outside. In general, in the process of processing an excimer laser ablation catheter, an end face of the head end of the interventional catheter 4 needs to be ground and polished, so that the light transmittance of the light emitting end of the excimer laser fiber 5 is improved, and the high-efficiency transmission of excimer laser in the fiber is ensured. The protruding structure of the end face of the interventional catheter 4 can be generally realized by controlling the grinding amounts of different portions of the end face thereof, specifically, by increasing the grinding removal amount of the peripheral portion of the end face of the interventional catheter 4, decreasing the grinding removal amount of the intermediate portion of the end face of the interventional catheter 4, and forming an outwardly protruding end face at the end face of the interventional catheter 4. The outwardly projecting end surface is typically provided with a surface of revolution coaxial with the interventional catheter 4, which surface of revolution may be conical, spherical, ellipsoidal or the like.
The head end of the excimer laser fiber 5 is connected to the protruding surface of the outer periphery of the end surface of the interventional catheter 4, so that the end surface of the head end of the excimer laser fiber 5 forms an inclined surface inclined to the outer periphery of the interventional catheter 4. When the excimer laser is emitted from the end face of the head end of the excimer laser fiber 5, the excimer laser deflects towards the peripheral direction of the interventional catheter 4, so that the irradiation range of the excimer laser emitted from the end face of the head end of the interventional catheter 4 is improved, and the efficiency of laser ablation on lesion tissues in blood vessels and hearts is improved.
In a preferred embodiment of the excimer laser ablation catheter of the present application, as shown in fig. 6, the outer peripheral portion of the end face of the head end of the interventional catheter 4 is formed as a curved surface protruding outward, and the middle portion of the end face is formed as a plane perpendicular to the central axis of the interventional catheter 4. Wherein, the head end of the inner cavity tube 41 is opened on the plane of the middle part of the end surface, so that the tube wall of the outlet of the inner cavity tube 41 is straight, the flow direction of the medicament flowing out through the inner cavity tube 41 is ensured to be stable, and the stimulation of the tube wall of the inner cavity tube 41 to the blood vessel and heart wall is reduced. The head end of the excimer laser fiber 5 is connected to the curved surface protruding outwards, so that the excimer laser emitted from the end surface of the excimer laser fiber 5 is ensured to diffuse towards the peripheral direction of the interventional catheter 4.
In another preferred embodiment of the excimer laser ablation catheter of the present application, as shown in fig. 7, the end surface of the head end of the interventional catheter 4 is integrally formed into a curved surface protruding outwards, and the curved surface may be a conical surface with the central axis of the interventional catheter 4 as a rotation axis or a spherical surface with the center of the sphere on the central axis of the interventional catheter 4. In addition, the end face of the head end of the interventional catheter 4 may be processed into an ellipsoid with the central axis of the interventional catheter 4 as a long axis, or another curved surface such as a paraboloid with the central axis of the interventional catheter 4 as a rotation axis.
In this embodiment, the end face of the head end of the interventional catheter 4 can be formed by one-time processing, and the processing is simpler. The specific shape of the convex curved surface can be reasonably selected according to the distribution requirement of excimer laser.
In the description of the present application, reference to the terms "one embodiment," "a particular embodiment," "a preferred embodiment," and the like, means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present application. In the present application, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The above embodiments are not intended to limit the scope of the present application, so: all equivalent changes in structure, shape and principle of the application should be covered in the scope of protection of the application.
Claims (10)
1. An excimer laser ablation catheter, characterized in that: including laser joint (1), fiber optic pipe (2), branch connector (3), intervention pipe (4) and excimer laser optic fibre (5), laser joint (1), fiber optic pipe (2), branch connector (3) and intervention pipe (4) link to each other in proper order, excimer laser optic fibre (5) by laser joint (1) warp fiber optic pipe (2) and branch connector (3) extend to the head end of intervention pipe (4), the inside of intervention pipe (4) is provided with inner chamber pipe (41), the one end of inner chamber pipe (41) with branch connector (3) are linked together, the other end opening in the head end of intervention pipe (4), inner chamber pipe (41) are made by polytetrafluoroethylene material, the head end outside crimping of inner chamber pipe (41) has go-between (42), the head end of excimer laser optic fibre (5) with go-between (42) with the wall sealing connection of intervention pipe (4).
2. The excimer laser ablation catheter of claim 1, wherein: the inner cavity tube (41) is positioned in the middle of the interventional catheter (4), and a plurality of excimer laser fibers (5) are wrapped around the periphery of the inner cavity tube (41).
3. The excimer laser ablation catheter of claim 2, wherein: the excimer laser fibers (5) are layered around the inner cavity tube (41) to form a plurality of concentric circles.
4. The excimer laser ablation catheter of claim 1, wherein: the connecting ring (42) is made of a metal material, and the connecting ring (42) is fixed at the head end of the inner cavity tube (41) through a spinning process.
5. The excimer laser ablation catheter of claim 4, wherein: the outer wall of the connecting ring (42) is flush with the outer wall adjacent the inner lumen tube (41).
6. An excimer laser ablation catheter according to claim 1, wherein: the head end of the intervention catheter (4) is provided with a developing ring (43), and the developing ring (43) is spliced at the head end of a sheath tube (44) at the outer layer of the intervention catheter (4) and is positioned at the outer side of the excimer laser optical fiber (5).
7. The excimer laser ablation catheter of claim 6, wherein: the developing ring (43) is made of tantalum alloy, or platinum iridium alloy.
8. The excimer laser ablation catheter of any one of claims 1-7, wherein: the end face of the head end of the interventional catheter (4) protrudes outwards, and the head end of the excimer laser fiber (5) is located on the protruding face.
9. The excimer laser ablation catheter of claim 8, wherein: the end face of the head end of the interventional catheter (4) comprises a plane positioned in the middle of the end face and an outer convex curved surface positioned at the periphery, the head end of the inner cavity tube (41) is positioned on the plane, and the head end of the excimer laser fiber (5) is positioned on the outer convex curved surface.
10. The excimer laser ablation catheter of claim 8, wherein: the end face of the head end of the interventional catheter (4) is a spherical surface.
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CN117462243A (en) * | 2023-12-27 | 2024-01-30 | 中日友好医院(中日友好临床医学研究所) | Laser ablation probe |
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CN117462243A (en) * | 2023-12-27 | 2024-01-30 | 中日友好医院(中日友好临床医学研究所) | Laser ablation probe |
CN117462243B (en) * | 2023-12-27 | 2024-03-22 | 中日友好医院(中日友好临床医学研究所) | Laser ablation probe |
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