CN116831544A - Puncture steel needle with in-situ pressure sensor chip and preparation method thereof - Google Patents
Puncture steel needle with in-situ pressure sensor chip and preparation method thereof Download PDFInfo
- Publication number
- CN116831544A CN116831544A CN202310908669.XA CN202310908669A CN116831544A CN 116831544 A CN116831544 A CN 116831544A CN 202310908669 A CN202310908669 A CN 202310908669A CN 116831544 A CN116831544 A CN 116831544A
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- China
- Prior art keywords
- layer
- steel needle
- pressure sensor
- puncture steel
- puncture
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910000831 Steel Inorganic materials 0.000 title claims abstract description 50
- 239000010959 steel Substances 0.000 title claims abstract description 50
- 238000011065 in-situ storage Methods 0.000 title claims abstract description 20
- 238000002360 preparation method Methods 0.000 title claims abstract description 12
- 238000009413 insulation Methods 0.000 claims abstract description 19
- 230000007704 transition Effects 0.000 claims abstract description 12
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 claims abstract description 11
- 230000008859 change Effects 0.000 claims abstract description 7
- 239000010410 layer Substances 0.000 claims description 54
- 238000000034 method Methods 0.000 claims description 16
- 239000011241 protective layer Substances 0.000 claims description 7
- 238000010292 electrical insulation Methods 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 6
- 238000005229 chemical vapour deposition Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000000151 deposition Methods 0.000 claims description 3
- 230000008021 deposition Effects 0.000 claims description 3
- 238000001312 dry etching Methods 0.000 claims description 3
- 238000007641 inkjet printing Methods 0.000 claims description 3
- 238000001755 magnetron sputter deposition Methods 0.000 claims description 3
- 238000000059 patterning Methods 0.000 claims description 3
- 238000001259 photo etching Methods 0.000 claims description 3
- 238000005240 physical vapour deposition Methods 0.000 claims description 3
- 230000008569 process Effects 0.000 claims description 3
- 238000004528 spin coating Methods 0.000 claims description 3
- 238000005507 spraying Methods 0.000 claims description 3
- 238000004544 sputter deposition Methods 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 238000001039 wet etching Methods 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 238000004891 communication Methods 0.000 claims 1
- 238000005516 engineering process Methods 0.000 abstract description 4
- 239000000853 adhesive Substances 0.000 abstract description 3
- 230000001070 adhesive effect Effects 0.000 abstract description 3
- 238000012545 processing Methods 0.000 abstract description 3
- 210000004204 blood vessel Anatomy 0.000 abstract description 2
- 239000003814 drug Substances 0.000 abstract description 2
- 239000010409 thin film Substances 0.000 abstract 3
- 229940079593 drug Drugs 0.000 abstract 1
- 210000001367 artery Anatomy 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- 230000004872 arterial blood pressure Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 208000029078 coronary artery disease Diseases 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000002586 coronary angiography Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000012625 in-situ measurement Methods 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000000302 ischemic effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 210000002321 radial artery Anatomy 0.000 description 1
- 238000002601 radiography Methods 0.000 description 1
- 230000010410 reperfusion Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000036262 stenosis Effects 0.000 description 1
- 208000037804 stenosis Diseases 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
- A61B5/02158—Measuring pressure in heart or blood vessels by means inserted into the body provided with two or more sensor elements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14542—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring blood gases
Abstract
The invention relates to the field of biological medicines and sensors, and discloses a puncture steel needle with an in-situ pressure sensor chip, which comprises a round puncture steel needle, wherein an electric insulation transition layer is arranged on the outer side of the round puncture steel needle, an electric insulation layer is arranged on the outer side of the electric insulation transition layer, a pressure sensor sensitive grid layer, a thin film lead wire and an external electrode are respectively arranged on the outer side of the electric insulation layer, the external electrode is connected with the thin film lead wire, an electric signal is led out to the external electrode through the thin film lead wire and is connected with an external electric signal measuring device, and the preparation of the sensor is based on a micro-nano processing technology. Because the sensor chip is prepared on the puncture steel needle in situ, an adhesive is not required, and the reliability problem caused by the large circular curvature is solved. When in use, the physical quantity of the arterial and venous pressure sensed by the puncture steel needle is obtained by measuring the resistance change of the pressure sensor, so that the arterial and venous of the blood vessel can be distinguished.
Description
Technical Field
The invention relates to the field of biological medicine and sensors, in particular to a puncture steel needle with an in-situ pressure sensor chip and a preparation method thereof.
Background
The arteriovenous puncture is a clinical operation of placing an arteriovenous puncture catheter into an artery and vein, can monitor the blood pressure of the artery by the arteriovenous puncture, has accurate measured blood pressure, can analyze the blood gas by the arteriovenous puncture, and can collect a blood sample once. The arteriovenous puncture can also be used for radiography, such as coronary angiography through radial artery, can accurately diagnose coronary heart disease, and provides good diagnosis basis for treatment. In addition, the artery and vein puncture can be used for interventional therapy, so that the related artery of stenosis or infarction can be opened, and the ischemic cardiac muscle can be fully reperfusion, thereby achieving the effect of treating coronary heart disease.
At present, when a traditional arteriovenous puncture needle is used for catheterization in an arteriovenous, on one hand, the puncture result is completely dependent on the experience of medical staff to adopt a blind puncture method, the medical staff needs to accumulate the experience of long-time prosthesis training and patient puncture to achieve the purpose of successful puncture, and various patients bring a lot of pains and possibly cause various complications; on the other hand, the arteriovenous distinction after puncture is always a difficult problem which medical staff want to solve, and the judgment of the arteriovenous distinction is completely dependent on experience or subsequent related instruments and equipment, and whether the catheter is placed into an artery or a vein can not be detected in real time in situ, so that the puncture steel needle with the in-situ pressure sensor chip and the preparation method thereof are provided.
Disclosure of Invention
(one) solving the technical problems
Aiming at the defects of the prior art, the invention provides a puncture steel needle with an in-situ pressure sensor chip and a preparation method thereof, and the preparation of the sensor is based on micro-nano processing technology. Because the sensor chip is prepared on the puncture steel needle in situ, an adhesive is not required, and the reliability problem caused by the large circular curvature is solved. When in use, the physical quantity of the arterial and venous pressure sensed by the puncture steel needle is obtained by measuring the resistance change of the pressure sensor, so that the arterial and venous of the blood vessel can be distinguished.
(II) technical scheme
In order to achieve the above purpose, the present invention provides the following technical solutions: the utility model provides a take puncture steel needle of normal position pressure sensor chip and preparation method thereof, includes circular puncture steel needle, and circular puncture steel needle outside is provided with the electric insulation transition layer, and the outside of electric insulation transition layer is provided with the electric insulation layer, and the outside of electric insulation layer is provided with pressure sensor sensitive bars layer, film lead wire and external electrode respectively, and external electrode connects the film lead wire, draws the electrical signal to external electrode through the film lead wire and connects external electrical signal measuring device.
Preferably, the outer sides of the sensitive grid layers and the film leads of the pressure sensor are respectively covered with protective layers.
Preferably, the electrode of the pressure sensor chip is connected with a film lead, and an electric signal generated by the sensitive gate layer of the pressure sensor is transmitted to the measuring equipment through the film lead and the external electrode, and the distinction of the active veins is carried out by analyzing the electric signal.
The preparation method of the puncture steel needle with the in-situ pressure sensor chip comprises the following steps:
firstly, carrying out oil removal treatment on the surface of a round puncture steel needle, and cleaning the round puncture steel needle by ionic water ultrasonic waves;
and secondly, preparing an electromechanical insulation transition layer and an electrical insulation layer on the surface of the round puncture steel needle by adopting a spraying or ink-jet printing method, and performing high-temperature curing treatment to tightly bond the electrical insulation layer and the substrate.
Covering a layer of sensitive layer material on the surface of the electric insulating layer by adopting a physical vapor deposition or chemical vapor deposition method, and patterning the sensitive layer material through rotary photoetching, dry etching or wet etching and lift-off technology to form a sensitive gate layer of the pressure sensor;
and fourthly, covering a layer of film lead on the puncture steel needle by utilizing magnetron sputtering deposition, and simultaneously preparing the external electrode by utilizing a rotary exposure and lift-off method according to the curvature change of the round puncture steel needle.
And fifthly, covering a protective layer on the sensitive gate layer and the film lead of the pressure sensor by utilizing a sputtering or spin coating method, and leaving an electrode area.
(III) beneficial effects
Compared with the prior art, the invention provides the puncture steel needle with the in-situ pressure sensor chip and the preparation method thereof, and the puncture steel needle has the following beneficial effects:
1. the puncture steel needle with the in-situ pressure sensor chip is used for preparing a pressure sensor on a round puncture steel needle in situ, is based on a micro-nano processing technology, combines the advantages of rotary exposure, has uniformity and repeatability in line width of a resistance grid of the pressure sensor, and can realize uniformity of measurement sensitivity on different steel needles.
2. The puncture steel needle with the in-situ pressure sensor chip is prepared on the puncture steel needle in-situ, so that the adhesive is not needed to be pasted, and the difficulty that the steel needle is difficult to paste due to undersize in the pasting process is overcome. Due to the characteristic of in-situ measurement, the sensor for measuring other parameters such as blood oxygen concentration and the like can be prepared simultaneously.
3. The puncture steel needle with the in-situ pressure sensor chip has the advantages of simple structure, high accuracy and high response speed.
Drawings
FIG. 1 is a schematic top view of the present invention;
FIG. 2 is a schematic view of section A-A in FIG. 1.
In the figure: 1. a pressure sensor sensitive gate layer; 2. a round puncture steel needle; 3. an electrically insulating transition layer; 4. an electrically insulating layer; 5. a protective layer; 6. film lead wire; 7. and (5) externally connecting an electrode.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1-2, a puncture steel needle with an in-situ pressure sensor chip comprises a round puncture steel needle 2, wherein an electric insulation transition layer 3 is arranged on the outer side of the round puncture steel needle 2, an electric insulation layer 4 is arranged on the outer side of the electric insulation transition layer 3, a pressure sensor sensitive grid layer 1, a film lead 6 and an external electrode 7 are respectively arranged on the outer side of the electric insulation layer 4, the external electrode 7 is connected with the film lead 6, and an electric signal is led out to the external electrode 7 through the film lead 6 and is connected with an external electric signal measuring device.
Further, the outer sides of the pressure sensor sensitive gate layer 1 and the film lead 6 are respectively covered with a protective layer 5.
Further, the electrode of the pressure sensor chip is connected with a film lead 6, an electric signal generated by the pressure sensor sensitive gate layer 1 is transmitted to measuring equipment through the film lead 6 and an external electrode 7, and the distinction of the active veins is carried out by analyzing the electric signal.
The preparation method of the puncture steel needle with the in-situ pressure sensor chip comprises the following steps:
firstly, carrying out oil removal treatment on the surface of a round puncture steel needle 2, and cleaning the round puncture steel needle by ionic water ultrasonic waves;
and secondly, preparing an electromechanical insulation transition layer 3 and an electrical insulation layer 4 on the surface of the round puncture steel needle 2 by adopting a spraying or ink-jet printing method, and performing high-temperature curing treatment to tightly bond the electrical insulation layer 4 with a substrate.
Covering a layer of sensitive layer material on the surface of the electric insulating layer 4 by adopting a physical vapor deposition or chemical vapor deposition method, and patterning the sensitive layer material through rotary photoetching, dry etching or wet etching and lift-off process to form a pressure sensor sensitive gate layer 1;
a fourth step of coating a layer of film lead 6 on the puncture steel needle by utilizing magnetron sputtering deposition, and simultaneously preparing an external electrode 7 by utilizing a rotary exposure and lift-off method according to the curvature change of the round puncture steel needle 2;
and fifthly, covering a protective layer 5 on the sensitive gate layer 1 of the pressure sensor and the film lead 6 by utilizing a sputtering or spin coating method, and leaving an electrode area.
When the round puncture steel needle 2 at the pressure sensor chip deforms under the action of arterial pressure, the size of the pressure sensor sensitive grid layer 1 is driven to change, and the resistance value of the pressure sensor is changed. After the relation between the pressure sensor resistance change and the arterial pressure is pre-calibrated, in practice, the arterial pressure and the venous pressure are distinguished by measuring the pressure sensor resistance.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (3)
1. The utility model provides a take puncture steel needle of normal position pressure sensor chip, a serial communication port, including circular puncture steel needle (2), circular puncture steel needle (2) outside is provided with electric insulation transition layer (3), the outside of electric insulation transition layer (3) is provided with electric insulation layer (4), the outside of electric insulation layer (4) is provided with pressure sensor sensitive bars layer (1) respectively, film lead wire (6) and external electrode (7), external electrode (7) connect film lead wire (6), draw forth the electrical signal to external electrode (7) and connect external electrical signal measuring device through film lead wire (6).
2. The steel needle with in-situ pressure sensor chip of claim 1, wherein: the outer sides of the pressure sensor sensitive grid layer (1) and the film lead (6) are respectively covered with a protective layer (5).
3. The preparation method of the puncture steel needle with the in-situ pressure sensor chip is characterized by comprising the following steps of:
firstly, carrying out oil removal treatment on the surface of a round puncture steel needle (2), and cleaning by ionic water ultrasonic waves;
secondly, preparing an electromechanical insulation transition layer (3) and an electrical insulation layer (4) on the surface of the round puncture steel needle (2) by adopting a spraying or ink-jet printing method, and performing high-temperature curing treatment to tightly combine the electrical insulation layer (4) with a substrate;
covering a layer of sensitive layer material on the surface of the electric insulating layer (4) by adopting a physical vapor deposition or chemical vapor deposition method, and patterning the sensitive layer material through rotary photoetching, dry etching or wet etching and lift-off process to form a sensitive gate layer (1) of the pressure sensor;
a fourth step of coating a layer of film lead (6) on the puncture steel needle by utilizing magnetron sputtering deposition, and simultaneously preparing an external electrode (7) by utilizing a rotary exposure and lift-off method according to the curvature change of the round puncture steel needle (2);
and fifthly, covering a protective layer (5) on the sensitive gate layer (1) of the pressure sensor and the film lead (6) by utilizing a sputtering or spin coating method, and leaving an electrode area.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310908669.XA CN116831544A (en) | 2023-07-19 | 2023-07-19 | Puncture steel needle with in-situ pressure sensor chip and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310908669.XA CN116831544A (en) | 2023-07-19 | 2023-07-19 | Puncture steel needle with in-situ pressure sensor chip and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116831544A true CN116831544A (en) | 2023-10-03 |
Family
ID=88163411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310908669.XA Pending CN116831544A (en) | 2023-07-19 | 2023-07-19 | Puncture steel needle with in-situ pressure sensor chip and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN116831544A (en) |
-
2023
- 2023-07-19 CN CN202310908669.XA patent/CN116831544A/en active Pending
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