CN106214135A - Domestic sphygmus measurement system based on flexible electronic skin - Google Patents

Domestic sphygmus measurement system based on flexible electronic skin Download PDF

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Publication number
CN106214135A
CN106214135A CN201610834385.0A CN201610834385A CN106214135A CN 106214135 A CN106214135 A CN 106214135A CN 201610834385 A CN201610834385 A CN 201610834385A CN 106214135 A CN106214135 A CN 106214135A
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CN
China
Prior art keywords
pulse
electronic skin
flexible electronic
nano wire
chip microcomputer
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Pending
Application number
CN201610834385.0A
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Chinese (zh)
Inventor
居乐乐
景博
黄敏
沈秋平
刘爱萍
钱巍
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Zhejiang Sci Tech University ZSTU
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Zhejiang Sci Tech University ZSTU
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Priority to CN201610834385.0A priority Critical patent/CN106214135A/en
Publication of CN106214135A publication Critical patent/CN106214135A/en
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/02Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6813Specially adapted to be attached to a specific body part
    • A61B5/6824Arm or wrist
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/68Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/683Means for maintaining contact with the body
    • A61B5/6832Means for maintaining contact with the body using adhesives
    • A61B5/6833Adhesive patches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2560/00Constructional details of operational features of apparatus; Accessories for medical measuring apparatus
    • A61B2560/04Constructional details of apparatus
    • A61B2560/0406Constructional details of apparatus specially shaped apparatus housings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/16Details of sensor housings or probes; Details of structural supports for sensors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Pathology (AREA)
  • Signal Processing (AREA)
  • Physiology (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Power Engineering (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)

Abstract

The present invention relates to a kind of domestic sphygmus measurement system based on electronic skin.This system includes: pulse signal collecting unit, signal processing circuit, single-chip microcomputer and display unit.The present invention uses flexible sensor to be affixed on wrist and gathers pulse signal, processes signal, by LCD Display Technique by hardware circuit and Single Chip Microcomputer (SCM) system, it is possible to achieve time monitoring and the signal output in fact of human pulse.The present invention be novel force-sensitive material and strain transducer exploitation and development provide reference.Monitor pulse in real time by flexible strain transducer, feedback in time is made in healthy data change, contribute to prevention and the diagnosis of the disease such as cardiovascular disease, coronary heart disease in early days.Its simple in construction, easy to use, lightweight, reliability is high, easy to carry, low cost, is beneficial to industrialization.As a kind of novel intelligent domestic armarium, there is higher practicality.

Description

Domestic sphygmus measurement system based on flexible electronic skin
Technical field
The present invention relates to the fields such as medical apparatus and instruments, sensor, signal processing technology, particularly relate to the Medical treatment device of a kind of domestic Tool field.
Background technology
In order to follow the tracks of health state nearly, modern for Portable household physiology monitoring instrument demand very Substantially.Traditional measure heart rate with heart rate monitor and use stethoscope pulse, can only reflect intuitively beat pulse number of times with And the height of heart rate, it is impossible to the distinctest physiological health situation thus measuring the measured reflected.Therefore, modern pulse condition Diagnosis needs to realize visualization, can measure the parameter of sphygmogram by analyzing sphygmogram.There are some researches show, pulse signal can With forecast cardiovascular disease in early days.Such as in the young patient of coronary heart disease, vascular lesion only shows that radial artery increases in early days Strong index (AI) increases, and the contraction pressure of periphery, pulse pressure do not raise, thus can be as disclosing youngster premature coronary artery The useful indicators of pathological changes, it is possible to as the New Set of assessment vessel aging.Visible, use the analysis means of science, pulse condition is believed It is imperative number to be analyzed.
Summary of the invention
Present invention aims to the deficiencies in the prior art, it is provided that a kind of domestic sphygmus measurement system.
It is an object of the invention to be achieved through the following technical solutions: a kind of domestic pulse based on flexible electronic skin is surveyed Amount system, including pulse signal collecting unit, signal processing circuit, single-chip microcomputer, display unit;Described pulse signal collecting unit Including flexible electronic skin, it is fitted at human body wrist and can gather the small strain due to beat pulse, and with the shape of the signal of telecommunication Formula exports;Described signal processing circuit includes amplifying circuit and filter circuit, is used for amplifying pulse signal waveform and filtering wherein Noise;Described single-chip microcomputer is for counting frequency of pulse per minute;Described display unit includes LCDs, is used for synchronizing Display pulse signal waveform and frequency of pulse per minute.
Further, described flexible electronic skin is prepared by the following method and obtains: cut by Cu nano wire-graphene film Go out the strip of 2cm × 0.5cm, two ends elargol is stained with copper cash, then embeds in polydimethylsiloxane (PDMS), be placed in 70 DEG C 2h in air dry oven, makes flexible electronic skin.The preparation method of described Cu nano wire-graphene film is as follows:
(1) in 20-25mL ethylene glycol solution, add 20-42mgCu nano wire, add 48-54mg after being uniformly dispersed anti-bad Hematic acid, adds 3-3.8mL graphene oxide, moves in hydrothermal reaction kettle after being uniformly dispersed, be placed on 120-160 DEG C of air blast and do Dry case reacts 4-6h, is cooled to room temperature, just obtains Cu nano wire-Graphene composite aquogel.
(2) Cu prepared nano wire-Graphene composite aquogel is placed in 0.5wt% hydrazine hydrate solution dialysis 16h, further takes out to pour in 150mL deionized water and is uniformly dispersed, and obtains suspension, then with core defecator sucking filtration, just obtains Cu nano wire-graphene film.
Further, described flexible electronic skin is pasted at user wrist by silica gel.
Further, described signal processing circuit, this circuit has been followed by second-order low-pass filter two amplifier stages Device, significantly can decay to noise signal, to ensure that pulse signal normally amplifies rather than is submerged among saturated.Electricity Road afterbody is provided with comparator, can direct output digit signals.
Further, the single-chip microcomputer that single-chip microcomputer can use model to be STC89C51.
Further, described in display unit, display unit includes LCDs, and can use model is LCD12864's Display screen.
The advantage of present system is: electronic skin is to have good soft elasticity, the flexible substrates of skin-friendly and Gao Ling The electrical-conductive nanometer material of sensitivity, the change in electric utilizing conductive material to be caused by slight pressure refers to the physiology detecting human body Mark.By uninterrupted to health and fitness information, obtain whenever and wherever possible, enable people to pay close attention at any time the healthy physical signs of oneself, Set up healthy lifestyles.Its simple in construction, easy to use, lightweight, reliability is high, easy to carry, low cost, be beneficial to produce Industry.As a kind of novel intelligent domestic armarium, there is higher practicality.
Accompanying drawing illustrates:
Fig. 1 is the photo in kind measuring pulse;
Fig. 2 is that pulse signal processes circuit theory diagrams;
Fig. 3 is the electric signal waveform figure measured with Keithley 2400 table and be attached to flexible skin sensor at wrist pulse.
Fig. 4 is digital display portion circuit flow chart;
Fig. 5 is the FB(flow block) of present system.
Detailed description of the invention:
A kind of domestic sphygmus measurement system based on flexible electronic skin, including pulse signal collecting unit, signal processing Circuit, single-chip microcomputer, display unit;
Described pulse signal collecting unit includes flexible electronic skin, is fitted at human body wrist and can gather owing to pulse is jumped Dynamic small strain, and export as electronic signals;
Described pulse signal collecting unit, critical piece is flexible electronic skin, the manufacture method of flexible electronic skin For: Cu nano wire-graphene film is cut the strip of 2cm × 0.5cm, two ends elargol is stained with copper cash, then embeds PDMS In, it is placed in 2h in 70 DEG C of air dry ovens, makes flexible electronic skin.Wherein, the preparation method of Cu nano wire-graphene film As follows:
(1) in 20-25mL ethylene glycol solution, add 20-42mgCu nano wire, add 48-54mg after being uniformly dispersed anti-bad Hematic acid, adds 3-3.8mL graphene oxide, moves in hydrothermal reaction kettle after being uniformly dispersed, be placed on 120-160 DEG C of air blast and do Dry case reacts 4-6h, is cooled to room temperature, just obtains Cu nano wire-Graphene composite aquogel.
(2) Cu prepared nano wire-Graphene composite aquogel is placed in 0.5wt% hydrazine hydrate solution dialysis 16h, further takes out to pour in 150mL deionized water and is uniformly dispersed, and obtains suspension, then with core defecator sucking filtration, just obtains Cu nano wire-graphene film.
Flexible electronic skin has higher susceptiveness and stability, and its shapes and sizes can be according to everyone wrist Feature is customized, it is ensured that flexible electronic skin can be close to wrist pulse and beat place, sensitive gathers beating of pulse Signal.
Described signal processing circuit includes amplifying circuit and filter circuit.In this embodiment noise signal be 20mV~ 50mV, and pulse signal size only has about 1mV.Owing to pulse signal is the small-signal under strong jamming, so putting at signal Big simultaneously need to avoid because the existence of noise makes amplifier saturated.This circuit has all followed second order after two amplifier stages Noise signal has been carried out significantly decaying by low pass filter, to ensure that pulse signal can normally amplify rather than be submerged in Among saturated;
Described single-chip microcomputer is for counting frequency of pulse per minute, and the output signal of the digital output end of front stage circuits is direct Input single-chip microcomputer (MCU), the timing of single-chip microcomputer intervalometer is set as 60s, counter records pulse in timing Number, timing just can show heart rate when of end;
Described display unit includes LCDs, for simultaneous display pulse signal waveform and pulse per minute Number.Output signal input digital to analog converter (ADC) of the analog output mouth of front stage circuits is converted into digital signal, and this numeral is believed Number input single-chip microcomputer (MCU), MCU carries out data interaction according to the sequential chart of liquid crystal display screen (LCD) with LCD, thus realizes on LCD Say that analog waveform shows.

Claims (5)

1. a domestic sphygmus measurement system based on flexible electronic skin, it is characterised in that: pulse signal collecting unit, signal Process circuit, single-chip microcomputer and display unit;
Described pulse signal collecting unit includes flexible electronic skin, is fitted at human body wrist and can gather due to beat pulse Small strain, and export as electronic signals;
Described signal processing circuit includes amplifying circuit and filter circuit, is used for amplifying pulse signal waveform and filtering therein making an uproar Sound;
Described single-chip microcomputer is for counting frequency of pulse per minute;
Described display unit includes LCDs, for simultaneous display pulse signal waveform and frequency of pulse per minute.
System the most according to claim 1, it is characterised in that described flexible electronic skin is prepared by the following method To: Cu nano wire-graphene film is cut the strip of 2cm × 0.5cm, two ends elargol is stained with copper cash, then embeds poly-two In methylsiloxane (PDMS), it is placed in 2h in 70 DEG C of air dry ovens, makes flexible electronic skin.Described Cu nano wire-graphite The preparation method of alkene thin film is as follows:
(1) in 20-25mL ethylene glycol solution, add 20-42mgCu nano wire, after being uniformly dispersed, add 48-54mg Vitamin C Acid, adds 3-3.8mL graphene oxide, moves in hydrothermal reaction kettle, be placed on 120-160 DEG C of forced air drying after being uniformly dispersed Case reacts 4-6h, is cooled to room temperature, just obtains Cu nano wire-Graphene composite aquogel.
(2) Cu prepared nano wire-Graphene composite aquogel is placed in 0.5wt% hydrazine hydrate solution dialysis 16h, then Taking-up is poured in 150mL deionized water and is uniformly dispersed, and obtains suspension, then with core defecator sucking filtration, just obtains Cu nanometer Line-graphene film.
System the most according to claim 1, it is characterised in that described signal processing circuit, this circuit is at two amplifier stages Be followed by second-order low-pass filter.
System the most according to claim 1, it is characterised in that the monolithic that single-chip microcomputer can use model to be STC89C51 Machine.
System the most according to claim 1, it is characterised in that described display unit includes LCD liquid crystal display screen, can adopt It is the display screen of LCD12864 by model.
CN201610834385.0A 2016-09-20 2016-09-20 Domestic sphygmus measurement system based on flexible electronic skin Pending CN106214135A (en)

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Application Number Priority Date Filing Date Title
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109247924A (en) * 2018-11-23 2019-01-22 上海海事大学 Pulse detection device and pulse detection method based on flexible strain transducer
CN110057474A (en) * 2019-03-01 2019-07-26 杭州电子科技大学 A kind of novel copper-based aeroge-PDMS combined pressure type pressure sensing material and its application
CN110123283A (en) * 2019-06-17 2019-08-16 深圳市城润科技股份有限公司 A kind of remote Chinese medical feeling the pulse system
CN110251114A (en) * 2019-07-04 2019-09-20 华东师范大学 A kind of compressible wearable finger arteries and veins measuring device

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4425922A (en) * 1981-04-07 1984-01-17 Bioresearch Inc. Electrical method and apparatus for non-invasively detecting abnormal flow in conduits
CN104706335A (en) * 2013-12-17 2015-06-17 中国科学院苏州纳米技术与纳米仿生研究所 Application of electronic skin to pulse detection and pulse detection system and method
CN105867628A (en) * 2016-04-18 2016-08-17 浙江理工大学 Flexible electronic skin based smart home gesture control system and control method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4425922A (en) * 1981-04-07 1984-01-17 Bioresearch Inc. Electrical method and apparatus for non-invasively detecting abnormal flow in conduits
CN104706335A (en) * 2013-12-17 2015-06-17 中国科学院苏州纳米技术与纳米仿生研究所 Application of electronic skin to pulse detection and pulse detection system and method
CN105867628A (en) * 2016-04-18 2016-08-17 浙江理工大学 Flexible electronic skin based smart home gesture control system and control method

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109247924A (en) * 2018-11-23 2019-01-22 上海海事大学 Pulse detection device and pulse detection method based on flexible strain transducer
CN110057474A (en) * 2019-03-01 2019-07-26 杭州电子科技大学 A kind of novel copper-based aeroge-PDMS combined pressure type pressure sensing material and its application
CN110057474B (en) * 2019-03-01 2021-04-13 杭州电子科技大学 Copper-based aerogel-PDMS composite piezoresistive pressure sensing material and application thereof
CN110123283A (en) * 2019-06-17 2019-08-16 深圳市城润科技股份有限公司 A kind of remote Chinese medical feeling the pulse system
CN110251114A (en) * 2019-07-04 2019-09-20 华东师范大学 A kind of compressible wearable finger arteries and veins measuring device

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Application publication date: 20161214

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