CN116808124A - Veterinary drug formula for pig estrus promotion - Google Patents

Veterinary drug formula for pig estrus promotion Download PDF

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Publication number
CN116808124A
CN116808124A CN202310166833.4A CN202310166833A CN116808124A CN 116808124 A CN116808124 A CN 116808124A CN 202310166833 A CN202310166833 A CN 202310166833A CN 116808124 A CN116808124 A CN 116808124A
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raw materials
estrus
veterinary drug
pig
radix
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谢国明
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235Foeniculum (fennel)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/752Citrus, e.g. lime, orange or lemon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
    • A61K36/8905Cyperus (flatsedge)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a veterinary drug formula for pig estrus promotion, which comprises the following raw materials in parts by mass: 10-20g of angelica sinensis, 8-16g of ligusticum wallichii, 8-16g of radix paeoniae alba, 8-16g of radix rehmanniae preparata, 8-16g of fennel, 5-15g of radix linderae, 10-20g of rhizoma cyperi and 10-20g of dried orange peel; the invention takes Chinese herbal medicines as main raw materials, is prepared by reasonable adjustment, has a synergistic effect among the components, and has obvious aphrodisiac effect: the feed has the effects of tonifying kidney, replenishing vital essence, strengthening yang, inducing estrus, warming channels and warming uterus, is added into daily ration of sows, and is continuously fed for 5-7 days, so that the estrus rate of the sows can reach more than 95%, the feed is simple to prepare, obvious in effect, safe and free of side effects, suitable for large-scale popularization and application of sow breeders, solves the key technological problems in pig industry, promotes the development of large-scale pig industry, and ensures the quality of life of people.

Description

Veterinary drug formula for pig estrus promotion
Technical Field
The invention relates to the technical field of sow aphrodisiac medicines, in particular to a veterinary drug formula for inducing estrus of pigs.
Background
The pig raising industry in China depends on a backward mode of home raising of farmers to a great extent, so that the supply of pork is tension and the price is increased easily, and an intensive large-scale pig raising base needs to be established, and the benefit of intensive pig raising depends on the reproductive capacity of sows, namely the annual number of births and the number of farrowings of each sow; the time of one year of sow consists of gestation period (114 days), lactation period (28 days) and non-production days, and since gestation period and lactation period are fixed, the number of litter size produced in one sow year has a direct relation with the non-production days, namely litter size= (365-non-production days)/(gestation period + lactation period). According to the normal law, the pregnant period of the sow is 114 days, the lactation period is 28-35 days, pregnancy and lactation are removed, other time is non-production time, namely, the non-production time is called by us, the time of the non-production time is related to the time from weaning to oestrus to mating, the conception rate of pregnant sows and the like, the current state of cultivation is that the oestrus rate in 7 days is between 70-80%, part of sows still can not normally oestrus in the pig farm for 40-50 days, and the non-production time is greatly increased; the conception rate of the sow is about 70%, the non-production number of the pig farm is more than 100 days, and each sow can only produce 1.8-2.0 litter per year on average. It is therefore of particular importance to shorten the non-productive days, i.e. to promote oestrus in sows.
Disclosure of Invention
In order to solve the technical problems, the technical scheme provided by the invention is as follows: a veterinary drug formula for pig estrus promotion comprises the following raw materials in parts by mass: 10-20g of angelica sinensis, 8-16g of ligusticum wallichii, 8-16g of radix paeoniae alba, 8-16g of radix rehmanniae preparata, 8-16g of fennel, 5-15g of radix linderae, 10-20g of rhizoma cyperi and 10-20g of dried orange peel.
Preferably, the material comprises the following raw materials in parts by mass: 15g of angelica sinensis, 12g of ligusticum wallichii, 12g of white paeony root, 12g of rehmannia glutinosa, 12g of fennel, 10g of combined spicebush root, 15g of nutgrass galingale rhizome and 15g of dried orange peel.
The preparation method comprises the following steps:
(1) Selecting raw materials according to a formula, cleaning and mixing, and soaking the raw materials in 100ml of wine for 1-2h;
(2) Decocting the soaked raw materials with 1000ml water, and removing 200-500ml water;
(3) When in use, the mixture is mixed with feed for feeding, and 100-200ml of distilled spirit is added.
The Chinese angelica has sweet taste and warm nature, has the effects of enriching and activating blood, regulating menstruation and relieving pain, relaxing bowel and the like, is commonly used for treating blood deficiency, blood stasis, intestine dryness and other symptoms, contains natural plant hormones, can relieve symptoms caused by endocrine dyscrasia, has the effect of enriching blood, and can lead qi and blood of people or animals to be smooth;
chuan Xiong is commonly used for promoting blood circulation and activating qi-flowing, dispelling wind and relieving pain, and is spicy, warm, fragrant and dry, and can be used for dispersing and ascending up to the peak; blood flows into the body and down to the sea. The effects of activating blood and removing stasis are wide, and the traditional Chinese medicine composition is suitable for various diseases of blood stasis retardation; has good effect of dispelling wind and relieving pain, and can be used for treating headache due to wind-damp arthralgia. The xian is called Chuan Xiong as qi-flowing medicine in blood, and has the functions of dispersing, resolving depression, promoting the circulation of qi, removing blood stasis and relieving pain;
white peony root is bitter in taste, sour, sweet and slightly cold; has effects in nourishing yin, softening liver, relieving pain, astringing yin, promoting perspiration, protecting liver, and can be used for treating diarrhea and abdominal pain, spontaneous perspiration, night sweat, yin deficiency, fever, menoxenia, metrorrhagia, leukorrhagia, gastrocnemius spasm, limb spasm pain, and restless leg syndrome; the researches show that the white paeony root has the effects of easing pain, resisting inflammation, enhancing hypoxia tolerance, resisting oxidation, resisting fatigue and hypodynamia, and has obvious effects of inhibiting the formation of liver lipid peroxide and scavenging free radicals;
the radix rehmanniae Preparata is root tuber of rehmanniae radix of Scrophulariaceae, also known as radix rehmanniae Preparata or radix rehmanniae Preparata, and is prepared by processing. Usually, wine, fructus amomi and dried orange peel are used as auxiliary materials, and the auxiliary materials are repeatedly steamed and sun-dried until the inside and outside colors are black and oily, and the texture is soft and sticky. For slicing or stir-baked into charcoal. The prepared rehmannia root, also called prepared rehmannia root or prepared rehmannia root, belongs to a figwort plant, is a superior traditional Chinese medicine, has the effects of enriching blood and nourishing yin, can be used for treating symptoms such as blood deficiency and sallow, dizziness, palpitation and insomnia, irregular menstruation, metrorrhagia and the like, can also be used for treating symptoms such as hectic fever and bone steaming, night sweat, spermatorrhea, diabetes and the like caused by deficiency of kidney yin, and is one of main components of a non-prescription medicine of the six-ingredient rehmannia pill of deficiency syndrome; is the key herb for tonifying kidney yin;
the fennel is mainly composed of fennel oil, can stimulate gastrointestinal nerve vessels, promote digestive juice secretion, increase gastrointestinal peristalsis and remove accumulated gas, so that the fennel has the effects of invigorating stomach and promoting qi circulation; sometimes gastrointestinal motility is reduced after excitation, thus helping to relieve cramps and pain; has effects in dispelling cold, relieving pain, regulating qi, regulating stomach function, warming kidney, reducing urination, promoting blood circulation, and relieving pain;
the black drug property is warm, and the taste is relatively fishy; can be good at guiding qi downward, regulating qi-flowing, warming cold evil and relieving pain, and is a main medicine for treating cold coagulation qi stagnation, abdominal pain, chest and abdomen pain, and is a preferred medicine for treating hernia and abdominal pain; has effects of regulating qi-flowing, dispelling cold, and relieving pain, and can be used for treating symptoms such as distention and pain of stomach and spleen due to deficiency-cold of spleen and stomach, and poor diet;
the nutgrass galingale rhizome has the effects of relieving fever, easing pain, anesthetizing, reducing temperature, protecting bronchus and resisting inflammation;
the dried orange peel has the effects of regulating qi, strengthening spleen, eliminating dampness and resolving phlegm;
compared with the prior art, the invention has the advantages that: the invention takes Chinese herbal medicines as main raw materials, is prepared by reasonable adjustment, has a synergistic effect among the components, and has obvious aphrodisiac effect: the feed has the effects of tonifying kidney, replenishing vital essence, strengthening yang, inducing estrus, warming channels and warming uterus, is added into daily ration of sows, and is continuously fed for 5-7 days, so that the estrus rate of the sows can reach more than 95%, the feed is simple to prepare, obvious in effect, safe and free of side effects, suitable for large-scale popularization and application of sow breeders, solves the key technological problems in pig industry, promotes the development of large-scale pig industry, and ensures the quality of life of people.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described in the following in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments.
Example 1
A veterinary drug formula for pig estrus promotion comprises the following raw materials in parts by mass: 10g of angelica sinensis, 8g of ligusticum wallichii, 8g of white paeony root, 8g of rehmannia glutinosa, 8g of fennel, 5g of combined spicebush root, 10g of nutgrass galingale rhizome and 10g of dried orange peel.
The preparation method comprises the following steps:
(1) Selecting raw materials according to a formula, cleaning and mixing, and soaking the raw materials in 100ml of wine for 1-2h;
(2) Decocting the soaked raw materials with 1000ml water, and removing 200-500ml water;
(3) When in use, the mixture is mixed with feed for feeding, and 100-200ml of distilled spirit is added.
Example two
The veterinary drug formula for inducing estrus of pigs is characterized by comprising the following raw materials in parts by mass: 20g of angelica sinensis, 16g of ligusticum wallichii, 16g of white paeony root, 16g of rehmannia glutinosa, 16g of fennel, 15g of combined spicebush root, 20g of nutgrass galingale rhizome and 20g of dried orange peel.
Example III
The veterinary drug formula for inducing estrus of pigs is characterized by comprising the following raw materials in parts by mass: 15g of angelica sinensis, 12g of ligusticum wallichii, 12g of white paeony root, 12g of rehmannia glutinosa, 12g of fennel, 10g of combined spicebush root, 15g of nutgrass galingale rhizome and 15g of dried orange peel.
1. Animal experiment
Selecting 100 non-oestrus sows in five branches of the pasture industry of Hongwang province of the city county of south China, carrying out diagnosis and treatment, dividing the selected 210 sows into three groups, wherein one group is an experimental group, the other group is a control group, the experimental group is a blank group, feeding the medicine of the invention, 100-200 ml/first sow every day, the control group feeding the existing medicine on the market, and the blank group is not fed with any medicine;
experiments are carried out 7 days later, the oestrus rate of the experimental group is 97%, the oestrus rate of the control group is 57%, the oestrus rate of the blank group is 20, and the oestrus rate of the blank group is 28%, so that the formula has the effect of promoting oestrus of sows.
The present invention and its embodiments have been described in detail, but not limited thereto, and those skilled in the art should appreciate that they can readily use the present invention without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (3)

1. The veterinary drug formula for inducing estrus of pigs is characterized by comprising the following raw materials in parts by mass: 10-20g of angelica sinensis, 8-16g of ligusticum wallichii, 8-16g of radix paeoniae alba, 8-16g of radix rehmanniae preparata, 8-16g of fennel, 5-15g of radix linderae, 10-20g of rhizoma cyperi and 10-20g of dried orange peel.
2. The veterinary drug formula for pig estrus according to claim 1, which is characterized by comprising the following raw materials in parts by mass: 15g of angelica sinensis, 12g of ligusticum wallichii, 12g of white paeony root, 12g of rehmannia glutinosa, 12g of fennel, 10g of combined spicebush root, 15g of nutgrass galingale rhizome and 15g of dried orange peel.
3. A veterinary drug formulation for pig estrus according to claim 1, which process comprises the steps of:
(1) Selecting raw materials according to a formula, cleaning and mixing, and soaking the raw materials in 100ml of wine for 1-2h;
(2) Decocting the soaked raw materials with 1000ml water, and removing 200-500ml water;
(3) When in use, the mixture is mixed with feed for feeding, and 100-200ml of distilled spirit is added.
CN202310166833.4A 2023-02-27 2023-02-27 Veterinary drug formula for pig estrus promotion Pending CN116808124A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102362942A (en) * 2011-08-24 2012-02-29 成都绿迪科技有限公司 Traditional Chinese medicinal formula for treating dysmenorrhoea
CN108403903A (en) * 2018-05-08 2018-08-17 佛山市粤三胖农业科技有限公司 A kind of sow with functions of promoting sexual maturity is scattered

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102362942A (en) * 2011-08-24 2012-02-29 成都绿迪科技有限公司 Traditional Chinese medicinal formula for treating dysmenorrhoea
CN108403903A (en) * 2018-05-08 2018-08-17 佛山市粤三胖农业科技有限公司 A kind of sow with functions of promoting sexual maturity is scattered

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
代广军;等: "规模养猪精细管理及新型疫病防控技术", 31 August 2006, 中国农业出版社, pages: 122 - 123 *
史轲利;等: "益母草散加减治疗奶牛不孕症", 中兽医学杂志, no. 05, 15 October 2011 (2011-10-15), pages 56 - 57 *
湖北农业信息网: "促使母猪多排卵多产仔的技术措施", pages 1, Retrieved from the Internet <URL:http://www.tonghua.gov.cn/ztzl/nw/nsnq/202205/t20220520_614405.html> *

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