CN116806710A - Medium and small animal aerosol exposure test equipment - Google Patents
Medium and small animal aerosol exposure test equipment Download PDFInfo
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- CN116806710A CN116806710A CN202310599817.4A CN202310599817A CN116806710A CN 116806710 A CN116806710 A CN 116806710A CN 202310599817 A CN202310599817 A CN 202310599817A CN 116806710 A CN116806710 A CN 116806710A
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- 239000000443 aerosol Substances 0.000 title claims abstract description 104
- 241001465754 Metazoa Species 0.000 title claims abstract description 71
- 238000012360 testing method Methods 0.000 title claims abstract description 33
- 239000002699 waste material Substances 0.000 claims abstract description 40
- 238000001914 filtration Methods 0.000 claims abstract description 36
- 239000004964 aerogel Substances 0.000 claims abstract description 22
- 238000005070 sampling Methods 0.000 claims description 29
- 238000012546 transfer Methods 0.000 claims description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000007788 liquid Substances 0.000 claims description 19
- 238000003860 storage Methods 0.000 claims description 16
- 238000011010 flushing procedure Methods 0.000 claims description 12
- 238000012544 monitoring process Methods 0.000 claims description 12
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 9
- 239000001301 oxygen Substances 0.000 claims description 9
- 229910052760 oxygen Inorganic materials 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 230000005540 biological transmission Effects 0.000 claims description 8
- 230000001105 regulatory effect Effects 0.000 claims description 7
- 230000001360 synchronised effect Effects 0.000 claims description 7
- 238000012545 processing Methods 0.000 claims description 5
- 230000035622 drinking Effects 0.000 claims description 4
- 239000003651 drinking water Substances 0.000 claims description 4
- 235000020188 drinking water Nutrition 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 abstract description 2
- 210000003608 fece Anatomy 0.000 abstract description 2
- 231100000054 whole-body exposure Toxicity 0.000 abstract description 2
- 238000010586 diagram Methods 0.000 description 6
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003116 impacting effect Effects 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/20—Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters
Landscapes
- Housing For Livestock And Birds (AREA)
Abstract
The invention discloses medium and small animal aerosol exposure test equipment, which relates to the field of animal test equipment, and comprises an animal exposure cabin and an aerogel disperser; an exhaust duct is arranged on the back of the animal exposure cabin and is communicated with an exhaust filtering system, an air inlet duct is arranged at the top of the inner cavity of the animal exposure cabin and is communicated with an air supply filtering system, a plurality of air outlet holes are formed in the exhaust surface of the air inlet duct, an aerogel disperser is communicated with an aerosol generating unit, a plurality of branch pipes are arranged on the aerogel disperser, and the lower ports of the branch pipes extend to the exhaust surface of the air inlet duct; the bottom of the inner cavity of the animal exposure cabin is provided with a waste collection tank, the top of the waste collection tank is provided with a supporting net, and the bottom of the waste collection tank is provided with a drain hole. The invention can enable the aerosol to dynamically flow in the whole-body exposure chamber, thereby ensuring the uniform concentration of the aerosol inhaled by the test animal; meanwhile, a waste collection system is additionally arranged at the bottom of the exposure cabin, so that automatic cleaning of animal excreta can be realized.
Description
Technical Field
The invention relates to the field of animal test equipment, in particular to medium and small animal aerosol exposure test equipment.
Background
Bacteria, viruses, fungi or other organic pathogens that are harmful to human health are often transmitted by means of aerogel in the air, which in turn leads to large-area infections in the population. In order to effectively understand the aerosol transmission infection process accompanied by organic pathogens, test personnel can take small animals such as mice, rats, guinea pigs, rabbits and the like as research objects to carry out an animal aerosol exposure test in a biosafety cabinet. The existing exposure test equipment mainly has the following defects: firstly, the aerosol after spraying is not easy to diffuse to the whole exposure cabin; secondly, after the exposure test is completed, the excrement of the animals in the cabin needs to be manually cleaned.
Disclosure of Invention
Based on the problems, the invention aims to provide small and medium animal aerosol exposure test equipment, which adopts the following technical scheme:
the invention provides a small and medium animal aerosol exposure test device, which comprises:
the biological safety cabinet comprises an animal exposure cabin and a waste storage cabin which are independent from each other, an operation door is arranged in front of the animal exposure cabin, operation gloves are arranged on the operation door, an exhaust duct is arranged at the lower part of the back of the animal exposure cabin, and the exhaust duct is communicated with an exhaust filtering system; an air inlet channel is formed in the top of the inner cavity of the animal exposure cabin and is communicated with the air supply filtering system, an air exhaust surface of the air inlet channel is an arc surface, and a plurality of air outlet holes are formed in the air exhaust surface of the air inlet channel; the bottom of the inner cavity of the animal exposure cabin is provided with a waste collection tank, the top of the waste collection tank is provided with a supporting net, the bottom of the waste collection tank is provided with a drain port, the drain port is connected with a waste collection box through a pipeline, and the waste collection box is positioned in the waste storage cabin;
the aerosol system comprises an aerosol generating unit, an aerosol sampling unit and an aerosol particle size monitoring unit, wherein the aerosol sampling unit and the aerosol particle size monitoring unit are communicated with the animal exposure cabin;
aerogel disperser, aerogel disperser is located the top of air inlet channel, aerogel disperser pass through the pipeline with aerosol generation unit intercommunication, be provided with a plurality of reposition of redundant personnel branch pipes on the aerogel disperser, the lower port of reposition of redundant personnel branch pipe extends to the face of airing exhaust of air inlet channel.
Preferably, the aerosol generating unit comprises an aerosol storage and a compressed air pipeline, an aerosol outlet is arranged at the top of the aerosol storage, a jet head protrudes inwards from the bottom of the aerosol storage, a nozzle is arranged at the top of the jet head, a liquid suction pipe is arranged at the outer side of the jet head, the upper end of the liquid suction pipe extends to the nozzle, and an impact baffle is arranged above the nozzle;
the compressed air pipeline is provided with a first Hepa filter, the compressed air pipeline is divided into two branches after passing through the first Hepa filter, one branch is communicated with the jet head, and the other branch is communicated with the aerosol outlet through a bypass regulating valve and then is communicated with the aerogel disperser as a spray output port.
Preferably, the aerosol outlet is arranged obliquely; the edge of the impact baffle is provided with a baffle net.
Preferably, the aerosol sampling unit comprises a liquid impact type sampling bottle, an air inlet of the liquid impact type sampling bottle is communicated with the animal exposure cabin through a sampling air inlet channel, an air outlet of the liquid impact type sampling bottle is communicated with an air extraction pipeline, and a steam-water separator and a second Hepa filter are arranged on the air extraction pipeline.
Preferably, the aerosol generating unit and the aerosol sampling unit are connected with a pneumatic control center through a gas circuit, the pneumatic control center comprises an air pump and an air pump, the air pump is connected with the compressed air pipeline, and the air pump is connected with the air pumping pipeline;
the biosafety cabinet further comprises an independent aerosol equipment compartment, and the aerosol system and the pneumatic control center are both located in the aerosol equipment compartment.
Preferably, the edge of the waste collection tank is provided with a plurality of flushing nozzles, the flushing nozzles being in communication with a water supply system, the water supply system being located in the waste storage compartment.
Preferably, a water baffle is arranged at the edge of the waste collection tank and is positioned above the flushing nozzle.
Preferably, a transfer chamber is arranged on one side of the biosafety cabinet, and the transfer chamber is communicated with the animal exposure cabin; the two ends of the transfer chamber are provided with openable sealing doors, and the transfer chamber is internally provided with a transmission device; the transmission device comprises a base, the base top is provided with the layer board, the layer board through two drawer slide rails that arrange side by side with the base is connected, the bottom surface of layer board is provided with the drive slot, be provided with the rack on the lateral wall of drive slot, the interval is provided with two gears on the base, two the gear all with rack engagement, two the up end of gear all is provided with synchronous pulley, two synchronous pulley passes through the belt and connects, one of them gear and driving motor power connection.
Preferably, the air supply filtering system comprises an air supply filtering device, an air inlet end of the air supply filtering device is communicated with the air feeder, an air outlet end of the air supply filtering device is divided into two air supply branches, one branch is communicated with the air inlet channel, and the other branch is communicated with the transfer chamber;
the exhaust filtering system comprises an exhaust filtering device, an air outlet end of the exhaust filtering device is communicated with an exhaust fan, an air inlet end of the exhaust filtering device is divided into two exhaust branches, one branch is communicated with the exhaust duct, and the other branch is communicated with the transfer chamber.
Preferably, an in-cabin environment monitoring unit is arranged in the animal exposure cabin, the in-cabin environment monitoring unit comprises a pressure sensor, a humidity sensor, a temperature sensor and an oxygen concentration sensor, and the pressure sensor, the humidity sensor, the temperature sensor and the oxygen concentration sensor are respectively connected with the central processing unit through analog-to-digital converters.
Preferably, the animal exposure cabin is also provided with a drinking water pipe and a trough; and a water drinking port is arranged on the water drinking pipe.
Compared with the prior art, the invention has the beneficial technical effects that:
the invention can dynamically flow the aerosol in the whole body exposure chamber, the distribution of the internal aerosol is more uniform, and the uniform concentration of the aerosol inhaled by the test animal is ensured; meanwhile, a waste collection system is additionally arranged at the bottom of the exposure cabin, so that automatic cleaning of animal excreta can be realized.
Drawings
The invention is further described with reference to the following description of the drawings.
FIG. 1 is a system flow diagram of a small and medium animal aerosol exposure test apparatus in an embodiment of the invention;
FIG. 2 is a schematic diagram of a biosafety cabinet according to an embodiment of the invention;
FIG. 3 is a schematic side view of a biosafety cabinet according to an embodiment of the invention;
FIG. 4 is a schematic diagram of an aerogel dispenser connected to an air inlet duct according to an embodiment of the present invention;
FIG. 5 is a system flow diagram of an aerosol generating unit according to an embodiment of the present invention;
FIG. 6 is a system flow diagram of an aerosol sampling unit according to an embodiment of the present invention;
fig. 7 is a schematic structural diagram of a transmission device according to an embodiment of the present invention.
Reference numerals illustrate: 1. a biosafety cabinet; 101. an animal exposure compartment; 102. a waste storage compartment; 103. an operation door; 104. an exhaust duct; 105. an air inlet duct; 105-1, an air outlet; 106. a waste collection tank; 106-1, flushing the spray head; 106-2, a water baffle; 107. a support net; 108. a drain port; 109. a waste collection tank; 110. an aerosol equipment compartment; 2. an exhaust filtering system; 201. an exhaust filtering device; 202. an exhaust fan; 3. an air supply filtering system; 301. an air supply filtering device; 302. a blower; 4. an aerosol system; 401. an aerosol generating unit; 401-1, aerosol reservoir; 401-2, compressed air lines; 401-3, sol outlet; 401-4, a jet head; 401-5, a nozzle; 401-6, pipette; 401-7, impacting a baffle; 401-8, a first Hepa filter; 401-9, by-pass regulating valve; 401-10, a blocking net; 402. an aerosol sampling unit; 402-1, a liquid impact type sampling bottle; 402-2, sampling an air inlet channel; 402-3, an air extraction pipeline; 402-4, a steam-water separator; 402-5, a second Hepa filter; 403. an aerosol particle size monitoring unit; 404. a pneumatic control center; 5. an aerogel disperser; 501. a branch pipe; 6. a transfer chamber; 601. sealing the door; 7. a transmission device; 701. a base; 702. a supporting plate; 703. a drawer slide; 704. a driving groove; 705. a rack; 706. a gear; 707. a synchronous pulley; 708. and driving the motor.
Detailed Description
In order to make the technical problems, technical schemes and beneficial effects to be solved more clear, the invention is further described in detail below with reference to the accompanying drawings and embodiments.
As shown in fig. 1, in this embodiment, a small and medium animal aerosol exposure test apparatus is disclosed, which includes a biosafety cabinet 1, an exhaust filter system 2, an air supply filter system 3, an aerosol system 4, and an aerogel dispenser 5.
In specific implementation, as shown in fig. 2 to 4, the biosafety cabinet 1 comprises an animal exposing cabin 101 and a waste storage cabin 102 which are independent from each other, an operation door 103 is arranged in front of the animal exposing cabin 101, the operation door 103 is a transparent door which is convenient for a tester to check the condition in the exposing cabin, the operation door 103 is provided with operation holes, operation gloves are hermetically arranged in each operation hole, and the tester can wear the operation gloves to extend into the animal exposing cabin 101 for operation. The top of operation door 103 passes through hinge or hinge swing joint on biological safety cabinet 1, and locking structure is installed to the bottom of operation door 103, and the periphery of operation door 103 is provided with two joint strip and improves the leakproofness of operation door 103. The left and right sides of the operation door 103 may be provided with pneumatic rods to assist in manually opening the operation door 103.
The lower part of the back of the animal exposing cabin 101 is provided with an exhaust duct 104, and the exhaust duct 104 is communicated with the exhaust filtering system 2. An air inlet channel 105 is arranged at the top of the inner cavity of the animal exposure cabin 101, the air inlet channel 105 is communicated with the air supply filtering system 3, the air exhaust surface of the air inlet channel 105 is an arc surface, and a plurality of air outlet holes 105-1 are formed in the air exhaust surface of the air inlet channel 105; the aerogel dispenser 5 is located the top of air inlet duct 105, and aerogel dispenser 5 passes through pipeline and aerosol generation unit 401 intercommunication, is provided with a plurality of reposition of redundant personnel branch pipes 501 on the aerogel dispenser 5, and the lower port of reposition of redundant personnel branch pipe 501 extends to the face of airing exhaust of air inlet duct 105. Clean air in the air inlet duct 105 is blown into the animal exposing chamber 101 through the air outlet hole 105-1, and the lower port of the branch pipe 501 is located at one side of the air outlet hole 105-1, so that the spreading of aerogel into the whole exposing chamber is accelerated.
The bottom of the inner cavity of the animal exposure chamber 101 is provided with a waste collection tank 106, the top of the waste collection tank 106 is provided with a supporting net 107, an animal cage can be placed on the supporting net 107, no scraps of animals can fall into the waste collection tank 106 through the supporting net 107, the bottom of the waste collection tank 106 is provided with a drain 108, the drain 108 is connected with a waste collection tank 109 through a pipeline, and the waste collection tank 109 is positioned in the waste storage chamber 102. In this embodiment, a plurality of flushing heads 106-1 are provided at the edge of the waste collection tank 106, the flushing heads 106-1 being in communication with a water supply system located in the waste storage compartment 102. The flushing head 106-1 can periodically flush the waste collection tank 106. The edge of the waste collection tank 106 is provided with a water baffle 106-2, and the water baffle 106-2 is positioned above the flushing sprinkler 106-1 to prevent high-pressure water sprayed by the flushing sprinkler 106-1 from splashing.
The aerosol system 4 is used for generating aerosol for test and sampling and detecting the aerosol, specifically, the aerosol system 4 comprises an aerosol generating unit 401, an aerosol sampling unit 402 and an aerosol particle size monitoring unit 403, and the aerosol sampling unit 402 and the aerosol particle size monitoring unit 403 are all communicated with the animal exposure cabin 101.
As shown in fig. 5, the aerosol generating unit 401 includes an aerosol reservoir 401-1 and a compressed air pipeline 401-2, an aerosol outlet 401-3 is provided at the top of the aerosol reservoir 401-1, a jet head 401-4 protrudes inward from the bottom of the aerosol reservoir 401-1, a nozzle 401-5 is provided at the top of the jet head 401-4, a liquid suction pipe 401-6 is provided at the outer side of the jet head 401-4, the upper end of the liquid suction pipe 401-6 extends to the nozzle 401-5, and an impact baffle 401-7 is provided above the nozzle 401-5. In operation, the compressed air line 401-2 provides compressed air to the nozzle 401-5, and the liquid medicine is sucked up by the negative pressure generated between the nozzle 401-5 and the pipette 401-6. The sucked chemical liquid is impacted to the upper impact plate 401-7, and turned into extremely fine mist aerosol to be sprayed outside. In this embodiment, a baffle 401-10 is disposed on the edge of the impact plate 401-7, and the baffle 401-10 can capture aerosol with larger particle size. Meanwhile, in the present embodiment, the aerosol outlet 401-3 is arranged obliquely; so as to be beneficial to the liquid drops wrapped by the aerosol with larger particle size to flow back into the double-mouth solution bottle.
The compressed air pipeline 401-2 is provided with a first Hepa filter 401-8, the compressed air pipeline 401-2 is divided into two branches after passing through the first Hepa filter 401-8, one branch is communicated with the jet head 401-4, the other branch is communicated with the aerosol outlet 401-3 through the bypass regulating valve 401-9 and then is communicated with the aerogel disperser 5 as a spray output port, and the outlet concentration of aerosol is controlled and regulated by regulating the bypass regulating valve 401-9.
As shown in fig. 6, the aerosol sampling unit 402 includes a liquid impact type sampling bottle 402-1, an air inlet of the liquid impact type sampling bottle 402-1 is communicated with the animal exposure cabin 101 through a sampling air inlet channel 402-2, an air outlet of the liquid impact type sampling bottle 402-1 is communicated with an air suction pipeline 402-3, and a steam-water separator 402-4 and a second Hepa filter 402-5 are arranged on the air suction pipeline 402-3.
As shown in fig. 1 and 2, in this embodiment, the aerosol generating unit 401 and the aerosol sampling unit 402 are connected to the pneumatic control center 404 through air paths, the pneumatic control center 404 includes an inflator, an air pump and a pressure gauge, the inflator is connected to the compressed air pipeline 401-2, and the air pump is connected to the air pump pipeline 402-3; biosafety cabinet 1 further includes a separate aerosol apparatus bay 110, with aerosol system 4 and air control center 404 both located in aerosol apparatus bay 110.
As shown in fig. 3 and 7, a transfer chamber 6 is provided at one side of the biosafety cabinet 1, and the transfer chamber 6 communicates with an animal exposure chamber 101; both ends of the transfer chamber 6 are provided with openable sealing doors 601, and the transfer chamber 6 is used for transferring the outside and the test tools in the animal exposure chamber 101 to each other. In the process of transferring the test tools, the test tools can be directly inserted into the transfer chamber 6 by hands to be taken and put, and the like, and a transfer device 7 can also be arranged in the transfer chamber 6.
In this embodiment, the transmission device 7 includes a base 701, a supporting plate 702 is disposed above the base 701, the supporting plate 702 is connected with the base 701 through two drawer slide rails 703 disposed side by side, a driving groove 704 is disposed on the bottom surface of the supporting plate 702, a rack 705 is disposed on a side wall of the driving groove 704, two gears 706 are disposed on the base 701 at intervals, the two gears 706 are engaged with the rack 705, synchronous pulleys 707 are disposed on upper end surfaces of the two gears 706, the two synchronous pulleys 707 are connected through a belt, and one of the gears 706 is in power connection with a driving motor 708. Two gears 706 are located at both ends of the base 701, so that when each gear 706 is separately matched with the rack 705, the movement range of the rack 705 is larger, and the support plate 702 can be deep into the animal exposing cabin 101 or can be pulled out from the transferring chamber 6 by combining the structure of the drawer slide 703.
In order to ensure that the conveyed test tool is clean and sterile, the air supply filtering system 3 in the embodiment comprises an air supply filtering device 301, wherein the air inlet end of the air supply filtering device 301 is communicated with an air blower 302, the air outlet end of the air supply filtering device 301 is divided into two air supply branches, one branch is communicated with the air inlet duct 105, and the other branch is communicated with the transfer chamber 6; meanwhile, the exhaust filtering system 2 comprises an exhaust filtering device 201, an air outlet end of the exhaust filtering device 201 is communicated with the exhaust fan 202, an air inlet end of the exhaust filtering device 201 is divided into two exhaust branches, one branch is communicated with the exhaust duct 104, and the other branch is communicated with the transfer chamber 6.
In this embodiment, an in-cabin environment monitoring unit is disposed in the animal exposure cabin 101, where the in-cabin environment monitoring unit includes a pressure sensor, a humidity sensor, a temperature sensor, and an oxygen concentration sensor, and the pressure sensor, the humidity sensor, the temperature sensor, and the oxygen concentration sensor are respectively connected to the central processor through analog-to-digital converters. The system is used for respectively acquiring oxygen content, temperature, humidity and pressure data in the exposure cabin in real time, transmitting the data to the central processing unit after analog-digital conversion, and analyzing, processing and storing the data by the central processing unit. From these data, the vital signs of the exposed animals can be analyzed, for example, when the oxygen content in the exposed cabin is detected to be too low, the test should be stopped, and the death of the exposed animals caused by the too low oxygen content is prevented.
In this embodiment, a drinking water pipe and a trough are also provided in the animal exposure cabin 101; be provided with the drink mouth on the drinking water pipe, a plurality of drink mouthfuls, trough correspond with the cage room, guarantee the normal existence of test animal.
The above embodiments are only illustrative of the preferred embodiments of the present invention and are not intended to limit the scope of the present invention, and various modifications and improvements made by those skilled in the art to the technical solutions of the present invention should fall within the protection scope defined by the claims of the present invention without departing from the design spirit of the present invention.
Claims (10)
1. A small and medium animal aerosol exposure test apparatus comprising:
the biological safety cabinet (1), the biological safety cabinet (1) comprises an animal exposure cabin (101) and a waste storage cabin (102) which are independent from each other, an operation door (103) is arranged in front of the animal exposure cabin (101), operation gloves are arranged on the operation door (103), an exhaust duct (104) is arranged at the lower part of the back of the animal exposure cabin (101), and the exhaust duct (104) is communicated with an exhaust filtering system (2); an air inlet channel (105) is formed in the top of the inner cavity of the animal exposure cabin (101), the air inlet channel (105) is communicated with the air supply filtering system (3), an air exhaust surface of the air inlet channel (105) is an arc surface, and a plurality of air outlet holes (105-1) are formed in the air exhaust surface of the air inlet channel (105); a waste collection tank (106) is arranged at the bottom of the inner cavity of the animal exposure cabin (101), a supporting net (107) is arranged at the top of the waste collection tank (106), a drain opening (108) is arranged at the bottom of the waste collection tank (106), the drain opening (108) is connected with a waste collection tank (109) through a pipeline, and the waste collection tank (109) is positioned in the waste storage cabin (102);
an aerosol system (4), the aerosol system (4) comprising an aerosol generating unit (401), an aerosol sampling unit (402) and an aerosol particle size monitoring unit (403), the aerosol sampling unit (402) and the aerosol particle size monitoring unit (403) being in communication with the animal exposure chamber (101);
aerogel disperser (5), aerogel disperser (5) are located the top of air inlet channel (105), aerogel disperser (5) pass through the pipeline with aerosol generation unit (401) intercommunication, be provided with a plurality of reposition of redundant personnel branch pipes (501) on aerogel disperser (5), the lower port of reposition of redundant personnel branch pipe (501) extends to the face of airing exhaust of air inlet channel (105).
2. The small and medium animal aerosol exposure test apparatus of claim 1, wherein: the aerosol generating unit (401) comprises an aerosol storage device (401-1) and a compressed air pipeline (401-2), an aerosol outlet (401-3) is formed in the top of the aerosol storage device (401-1), a jet head (401-4) protrudes inwards from the bottom of the aerosol storage device (401-1), a nozzle (401-5) is formed in the top of the jet head (401-4), a liquid suction pipe (401-6) is arranged on the outer side of the jet head (401-4), the upper end of the liquid suction pipe (401-6) extends to the nozzle (401-5), and an impact baffle (401-7) is arranged above the nozzle (401-5);
the compressed air pipeline (401-2) is provided with a first Hepa filter (401-8), the compressed air pipeline (401-2) is divided into two branches after passing through the first Hepa filter (401-8), one branch is communicated with the air jet head (401-4), and the other branch is communicated with the aerosol outlet (401-3) through a bypass regulating valve (401-9) and then is used as a spray output port to be communicated with the aerogel disperser (5).
3. The small and medium animal aerosol exposure test apparatus of claim 2, wherein: the aerosol outlet (401-3) is arranged obliquely; the edge of the impact baffle plate (401-7) is provided with a baffle net (401-10).
4. The small and medium animal aerosol exposure test apparatus of claim 2, wherein: the aerosol sampling unit (402) comprises a liquid impact type sampling bottle (402-1), an air inlet of the liquid impact type sampling bottle (402-1) is communicated with the animal exposure cabin (101) through a sampling air inlet channel (402-2), an air outlet of the liquid impact type sampling bottle (402-1) is communicated with an air exhaust pipeline (402-3), and a steam-water separator (402-4) and a second Hepa filter (402-5) are arranged on the air exhaust pipeline (402-3).
5. The small and medium animal aerosol exposure test apparatus of claim 4, wherein: the aerosol generating unit (401) and the aerosol sampling unit (402) are connected with the pneumatic control center (404) through air paths, the pneumatic control center (404) comprises an air pump and an air extracting pump, the air pump is connected with the compressed air pipeline (401-2), and the air extracting pump is connected with the air extracting pipeline (402-3);
the biosafety cabinet (1) further comprises a separate aerosol equipment compartment (110), and the aerosol system (4) and the air control center (404) are both located in the aerosol equipment compartment (110).
6. The small and medium animal aerosol exposure test apparatus of claim 1, wherein: the edge of the waste collection tank (106) is provided with a plurality of flushing nozzles (106-1), and the flushing nozzles (106-1) are communicated with a water supply system, and the water supply system is positioned in the waste storage cabin (102).
7. The small and medium animal aerosol exposure test apparatus of claim 6, wherein: the edge of the waste collection tank (106) is provided with a water baffle (106-2), and the water baffle (106-2) is positioned above the flushing nozzle (106-1).
8. The small and medium animal aerosol exposure test apparatus of claim 1, wherein: a transfer chamber (6) is arranged on one side of the biosafety cabinet (1), and the transfer chamber (6) is communicated with the animal exposure cabin (101); both ends of the transfer chamber (6) are provided with openable sealing doors (601), and a transmission device (7) is arranged in the transfer chamber (6); the transmission device (7) comprises a base (701), a supporting plate (702) is arranged above the base (701), the supporting plate (702) is connected with the base (701) through two drawer sliding rails (703) which are arranged side by side, a driving groove (704) is formed in the bottom surface of the supporting plate (702), a rack (705) is arranged on one side wall of the driving groove (704), two gears (706) are arranged on the base (701) at intervals, the two gears (706) are meshed with the rack (705), synchronous pulleys (707) are arranged on the upper end faces of the two gears (706), the two synchronous pulleys (707) are connected through a belt, and one of the gears (706) is in power connection with a driving motor (708).
9. The small and medium animal aerosol exposure test apparatus of claim 8, wherein: the air supply filtering system (3) comprises an air supply filtering device (301), wherein an air inlet end of the air supply filtering device (301) is communicated with the air feeder (302), an air outlet end of the air supply filtering device (301) is divided into two air supply branches, one branch is communicated with the air inlet duct (105), and the other branch is communicated with the transfer chamber (6);
the exhaust filtering system (2) comprises an exhaust filtering device (201), an air outlet end of the exhaust filtering device (201) is communicated with an exhaust fan (202), an air inlet end of the exhaust filtering device (201) is divided into two exhaust branches, one branch is communicated with the exhaust duct (104), and the other branch is communicated with the transfer chamber (6).
10. The small and medium animal aerosol exposure test apparatus of claim 1, wherein: an in-cabin environment monitoring unit is arranged in the animal exposure cabin (101), and comprises a pressure sensor, a humidity sensor, a temperature sensor and an oxygen concentration sensor, wherein the pressure sensor, the humidity sensor, the temperature sensor and the oxygen concentration sensor are respectively connected with a central processing unit through analog-to-digital converters;
a drinking water pipe and a trough are also arranged in the animal exposure cabin (101); and a water drinking port is arranged on the water drinking pipe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310599817.4A CN116806710B (en) | 2023-05-25 | 2023-05-25 | Medium and small animal aerosol exposure test equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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| US20020103443A1 (en) * | 2001-01-31 | 2002-08-01 | Roy Chad J. | Automated inhalation toxicology exposure system |
| KR20120037096A (en) * | 2010-10-11 | 2012-04-19 | (주)에이치시티 | Cage type apparatus for testing inhalation toxicity of aerosol paticles |
| CN204841720U (en) * | 2014-08-29 | 2015-12-09 | 中国人民解放军军事医学科学院军事兽医研究所 | Biohazard safety equipment is with small -size aerosol transmission evaluation test device |
| CN105651944A (en) * | 2016-02-25 | 2016-06-08 | 青岛众瑞智能仪器有限公司 | Animal aerosol exposure experiment system |
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| CN109512541A (en) * | 2017-09-19 | 2019-03-26 | 中国人民解放军军事科学院军事医学研究院微生物流行病研究所 | Medium and small animal organism aerosol mouth and nose exposure system |
| CN111011221A (en) * | 2018-10-10 | 2020-04-17 | 中国人民解放军军事科学院军事医学研究院 | High-grade biological safety protection type small and medium animal pathogen air transmission experimental device |
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| US20020103443A1 (en) * | 2001-01-31 | 2002-08-01 | Roy Chad J. | Automated inhalation toxicology exposure system |
| KR20120037096A (en) * | 2010-10-11 | 2012-04-19 | (주)에이치시티 | Cage type apparatus for testing inhalation toxicity of aerosol paticles |
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