CN116803299A - Mountain pomelo oil health food capable of assisting in reducing blood sugar and preparation method thereof - Google Patents
Mountain pomelo oil health food capable of assisting in reducing blood sugar and preparation method thereof Download PDFInfo
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- CN116803299A CN116803299A CN202310733702.XA CN202310733702A CN116803299A CN 116803299 A CN116803299 A CN 116803299A CN 202310733702 A CN202310733702 A CN 202310733702A CN 116803299 A CN116803299 A CN 116803299A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention provides a mountain pomelo oil health food capable of assisting in reducing blood sugar and a preparation method thereof, wherein the mountain pomelo oil health food is prepared from the following raw materials in parts by weight: 50-60 parts of pomelo oil, 16-18 parts of soybean isoflavone, 15-20 parts of dietary fiber, 12-15 parts of bifidobacterium, 10-15 parts of lactobacillus, 10-12 parts of cyclodextrin, 8-12 parts of chitosan, 8-10 parts of peptide powder, 6-8 parts of soybean lecithin, 8-10 parts of momordica grosvenori extract and 0.1-0.5 part of yeast; the peptide powder is one or more than two of corn peptide powder, soybean peptide powder and wheat peptide powder; the yeast comprises chromium-enriched yeast, magnesium-enriched yeast, zinc-enriched yeast and calcium-enriched yeast. In the invention, the active ingredients such as the pomelo oil, the soybean isoflavone, the dietary fiber, the bifidobacterium, the lactobacillus, the cyclodextrin, the peptide powder and the like are compounded, so that the preparation is scientific in compatibility, safe and reliable, and the effect of effectively assisting in reducing blood sugar can be achieved from different angles.
Description
Technical Field
The invention relates to the field of health-care food, in particular to a pomelo oil health-care food capable of assisting in reducing blood sugar and a preparation method thereof.
Background
With the improvement of the living standard of modern people, the living style and the diet structure of people are greatly changed, and the probability of suffering from various diseases is increased to a certain extent. Diabetes is a metabolic disease characterized mainly by hyperglycemia, and is accompanied by a series of complications involving multiple tissues and organs. Most commonly, such as nephropathy, retinopathy, neuropathy, cardiomyopathy, etc., can cause diabetics to suffer from blindness, stroke, renal failure, heart attack, etc., severely affecting physical and mental health. The traditional Chinese medicine is three-component toxin, and the conventional diabetes treatment medicines at present comprise glimepiride, metformin, acarbose and the like, and have the toxic and side effects of hypoglycemia, large blood sugar fluctuation, gastrointestinal tract reaction and the like in the use process, and the long-term administration of the traditional Chinese medicine can generate drug resistance, so that the application of the traditional Chinese medicine is limited. Along with the improvement of the living standard of people, the market demand of traditional Chinese medicine health products is more and more increased, and the traditional Chinese medicine health products become an important component of national health industry. The auxiliary blood sugar-reducing health food is suitable for people with high blood sugar, can regulate body functions of human bodies, does not generate any acute, subacute or chronic harm to the human bodies, and becomes more and more dependent on people. At present, the existing auxiliary blood sugar-reducing health-care food is prepared by mixing and compounding a plurality of Chinese herbal medicines, and has an auxiliary blood sugar-reducing effect to a certain extent, but has an unobvious effect.
Tea-oil camellia, also known as tea tree, tea oil tree, is commonly referred to in Hainan as pomelo, and the oil prepared from pomelo seeds is referred to as pomelo oil. The mountain pomelo is mainly distributed in the counties of Jones, chengmai, and Anemone of Hainan, and the mountain pomelo oil contains rich nutrition because mountain camellia seeds with good quality can be produced in the unique geographical environment of Hainan. The content of unsaturated fatty acid in the pomelo oil is up to more than 90%, and the content of oleic acid is up to 80-83%, so that the content of different varieties is slightly different. As the Hainan mountain pomelo oil contains a plurality of functional components, the Hainan mountain pomelo oil has the special effects of protecting heart, reducing blood sugar, regulating blood fat, reducing cholesterol, resisting inflammation, preventing cancer and the like, and is an ideal raw material for developing health-care food. However, the application of the pomelo oil to the health-care food is less in the current research, so that the pomelo oil has a wide application prospect in the health-care food.
Disclosure of Invention
In view of the above, the invention provides a pomelo oil health food capable of assisting in reducing blood sugar and a preparation method thereof.
The technical scheme of the invention is realized as follows:
a pomelo oil health food capable of assisting in reducing blood sugar is prepared from the following raw materials in parts by weight: 50-60 parts of pomelo oil, 16-18 parts of soybean isoflavone, 15-20 parts of dietary fiber, 12-15 parts of bifidobacterium, 10-15 parts of lactobacillus, 10-12 parts of cyclodextrin, 8-12 parts of chitosan, 8-10 parts of peptide powder, 6-8 parts of soybean lecithin, 8-10 parts of momordica grosvenori extract and 0.1-0.5 part of yeast;
the peptide powder is one or the combination of more than two of corn peptide powder, soybean peptide powder and wheat peptide powder;
the yeast consists of chromium-enriched yeast, magnesium-enriched yeast, zinc-enriched yeast and calcium-enriched yeast.
Further, the dietary fiber is one or the combination of more than two of konjak glucomannan, sodium alginate, acacia and guar gum.
Further, the mass ratio of the chromium-enriched yeast to the magnesium-enriched yeast to the zinc-enriched yeast to the calcium-enriched yeast is 1:1:1:1.
Further, the preparation method of the pomelo oil comprises the following steps: and (3) drying the pomelo seeds in a vacuum dryer to ensure that the water content of the camellia seeds is 5-6%, taking out, crushing in a crusher to obtain crushed materials, putting the crushed materials in a subcritical extractor, adding an extractant butane for sealed vacuum extraction, filtering after extraction is finished, and centrifugally separating filtrate to obtain the pomelo oil.
Further, the drying conditions in the vacuum dryer are as follows: the temperature is 30-50 ℃, the vacuum degree is minus 0.06-minus 0.09MPa, and the extraction conditions in the subcritical extractor are as follows: the extraction temperature is 40-50 ℃, the pressure is 7.5-9.0 MPa, the extraction time is 1-3 h, and the extraction is 2-3 times; the centrifugal separation conditions are as follows: setting the rotating speed at 2000-3000 r/min, centrifuging for 10-15 min, standing for 2-3 h and separating.
The preparation method of the mountain pomelo oil health food capable of assisting in reducing blood sugar comprises the following steps:
s1, preparing a wall material solution: mixing cyclodextrin, soybean lecithin and water, and performing ultrasonic treatment at 100-200W for 2-4 min to prepare a compound solution A; adding pomelo oil into the composite solution A, stirring and mixing at high speed to obtain emulsion, homogenizing the emulsion at high pressure to obtain emulsion, and spray drying to obtain capsule micropowder A;
s2, adding chitosan into 0.1mol/L acetic acid solution to completely dissolve the chitosan, thereby obtaining chitosan solution; adding the microcapsule powder A, the bifidobacterium, the lactobacillus and the yeast prepared in the step S1 into chitosan solution, stirring and mixing uniformly at a high speed, washing for 2-3 times by using distilled water, and then freeze-drying to obtain microcapsule powder B;
and S3, uniformly stirring and mixing the microcapsule powder B, the peptide powder, the soybean isoflavone, the dietary fiber, the maltodextrin and the momordica grosvenori extract prepared in the step S2, granulating, and tabletting to obtain the pomelo oil health-care food capable of assisting in reducing blood sugar.
Further, the spray drying conditions are as follows: the air inlet temperature is 160-170 ℃, the air outlet temperature is 60-80 ℃, the fan frequency is 40-45 Hz, and the atomization pressure is 0.2-0.25 MPa.
Further, the high-pressure homogenizing condition is that firstly homogenizing for 1-2 times under 10-20 MPa, each time homogenizing for 4-5 min, then raising the homogenizing pressure to 40-50 MPa for 1-2 times, each time homogenizing for 3-4 min.
Compared with the prior art, the invention has the beneficial effects that:
1. in the invention, the active ingredients such as the pomelo oil, the soybean isoflavone, the dietary fiber, the bifidobacterium, the lactobacillus, the cyclodextrin, the peptide powder and the like are compounded, so that the preparation is scientific in compatibility, safe and reliable, and the effect of effectively assisting in reducing blood sugar can be achieved from different angles.
2. In the invention, the soybean lecithin can promote the repairing effect of pancreatic cells in vivo, the pomelo oil contains rich unsaturated fatty acid and other active ingredients, and can promote the insulin secretion of islet cells under the interaction of the pomelo oil and the soybean lecithin, and can also promote the stability of the insulin in blood, thereby achieving good auxiliary blood glucose reducing effect; the soybean isoflavone can play a role in rapidly removing oxygen free radicals and reduce the damage of cell oxidation, so that the metabolism of saccharides can be improved, and the effect of assisting in reducing blood sugar is achieved.
3. Dietary fiber and cyclodextrin can wrap carbohydrate substances, can slow down the entry of high-starch food into intestinal tracts, slow down the speed of absorbing starch food by intestines and stomach, is beneficial to regulating and stabilizing blood sugar, and slowing down the rise of blood sugar, is beneficial to promoting the peristalsis of intestines and stomach, can reduce the deposition of substances such as fat and the like in the bodies, and plays a role in improving the intestinal tracts; the cyclodextrin can also inhibit the growth of harmful bacteria in intestinal tracts, and simultaneously has the function of promoting the growth of bifidobacteria and lactobacillus, thereby reducing the disturbance of in-vivo metabolic functions caused by the rise of blood sugar and promoting the health of organisms. In addition, the cyclodextrin can improve the stability of each component in the health food, thereby improving the shelf life of the product.
4. The peptide powder can play a role in regulating blood sugar bidirectionally, and can also improve the antioxidation of organisms, protect liver and kidney, improve organism immunity and reduce or prevent other complications; the fructus momordicae extract can promote insulin secretion and reduce the damage capability of islet cells, so that the effect of reducing blood sugar is achieved, the sweet taste of the health food can be enhanced, the flavor of the health food is improved, the resistance of a human body can be improved, in addition, the antibacterial effect can be achieved, and the storage stability of the health food is improved.
5. Chromium-rich yeasts, magnesium-rich yeasts, zinc-rich yeasts and calcium-rich yeasts can enhance insulin sensitivity; the blood sugar is increased, and meanwhile, the loss of elements required by organisms such as calcium and magnesium is driven, for example, osteoporosis and the like can be caused by the loss of calcium ions, and the yeast added with the elements can improve the resistance of the human body and promote the health of the organisms, so that the effect of assisting in regulating the blood sugar is achieved.
6. In the preparation process, the pomelo oil, the bifidobacteria, the lactobacillus and the yeast are firstly prepared into the microcapsule, so that the stability can be improved, the release time of active ingredients in the health food can be slowed down after the pomelo oil is eaten, the regulation effect on blood sugar is prolonged, and the condition that the blood sugar of a human body is regulated once is avoided, so that the blood sugar is suddenly high and suddenly low, and the human body is damaged.
Detailed Description
In order to better understand the technical content of the present invention, the following provides specific examples to further illustrate the present invention.
The experimental methods used in the embodiment of the invention are conventional methods unless otherwise specified.
Materials, reagents, and the like used in the examples of the present invention are commercially available unless otherwise specified.
Example 1
The mountain pomelo oil health food capable of assisting in reducing blood sugar in the implementation is prepared from the following raw materials in parts by weight: 50 parts of pomelo oil, 16 parts of soybean isoflavone, 15 parts of dietary fiber, 12 parts of bifidobacterium, 10 parts of lactobacillus, 10 parts of cyclodextrin, 8 parts of chitosan, 8 parts of corn peptide powder, 6 parts of soybean lecithin, 8 parts of momordica grosvenori extract and 0.1 part of yeast; the dietary fiber is a combination of konjak glucomannan and sodium alginate in a mass ratio of 1:1; the mass ratio of the chromium-enriched yeast to the magnesium-enriched yeast to the zinc-enriched yeast to the calcium-enriched yeast in the yeast is 1:1:1:1;
the preparation method of the mountain pomelo oil health food capable of assisting in reducing blood sugar comprises the following steps:
s1, preparing a wall material solution: mixing cyclodextrin, soybean lecithin and water, and performing ultrasonic treatment at 100 deg.F for 2min to obtain compound solution A; adding pomelo oil into the composite solution A, stirring and mixing at high speed to obtain emulsion, homogenizing the emulsion under 10MPa for 1 time, homogenizing for 4min each time, raising the homogenizing pressure to 40MPa for 1 time, homogenizing for 3min each time to obtain emulsion, and spray-drying the emulsion at air inlet temperature of 160deg.C, air outlet temperature of 60deg.C, fan frequency of 40Hz and atomization pressure of 0.2MPa to obtain capsule micropowder A;
s2, adding chitosan into 0.1mol/L acetic acid solution to completely dissolve the chitosan, thereby obtaining chitosan solution; adding the microcapsule powder A, the bifidobacterium, the lactobacillus and the yeast prepared in the step S1 into chitosan solution, stirring and mixing uniformly at a high speed, washing for 2 times by using distilled water, and then freeze-drying to obtain microcapsule powder B;
and S3, uniformly stirring and mixing the microcapsule powder B, the corn peptide powder, the soybean isoflavone, the dietary fiber and the fructus momordicae extract prepared in the step S2, granulating, and tabletting to obtain the mountain pomelo oil health food capable of assisting in reducing blood sugar.
Example 2
The mountain pomelo oil health food capable of assisting in reducing blood sugar in the implementation is prepared from the following raw materials in parts by weight: 60 parts of pomelo oil, 18 parts of soybean isoflavone, 20 parts of dietary fiber, 15 parts of bifidobacterium, 15 parts of lactobacillus, 12 parts of cyclodextrin, 12 parts of chitosan, 10 parts of soybean peptide powder, 8 parts of soybean lecithin, 10 parts of momordica grosvenori extract and 0.5 part of yeast; the dietary fiber is a combination of sodium alginate and acacia in a mass ratio of 2:1; the mass ratio of the chromium-enriched yeast to the magnesium-enriched yeast to the zinc-enriched yeast to the calcium-enriched yeast in the yeast is 1:1:1:1;
the preparation method of the mountain pomelo oil health food capable of assisting in reducing blood sugar comprises the following steps:
s1, preparing a wall material solution: mixing cyclodextrin, soybean lecithin and water, and performing ultrasonic treatment at 200W for 4min to obtain a compound solution A; adding pomelo oil into the composite solution A, stirring and mixing at high speed to obtain emulsion, homogenizing the emulsion at 20MPa for 2 times and 5min each time, then raising the homogenizing pressure to 50MPa for 2 times and 4min each time to obtain emulsion, and spray-drying the emulsion at 170 ℃ of air inlet temperature, 80 ℃ of air outlet temperature, 45Hz of fan frequency and 0.25MPa of atomizing pressure to obtain capsule micropowder A;
s2, adding chitosan into 0.1mol/L acetic acid solution to completely dissolve the chitosan, thereby obtaining chitosan solution; adding the microcapsule powder A, the bifidobacterium, the lactobacillus and the yeast prepared in the step S1 into chitosan solution, stirring and mixing uniformly at a high speed, washing for 3 times by using distilled water, and then freeze-drying to obtain microcapsule powder B;
and S3, uniformly stirring and mixing the microcapsule powder B, the soybean peptide powder, the soybean isoflavone, the dietary fiber and the fructus momordicae extract prepared in the step S2, granulating, and tabletting to obtain the mountain pomelo oil health food capable of assisting in reducing blood sugar.
Example 3
The mountain pomelo oil health food capable of assisting in reducing blood sugar in the implementation is prepared from the following raw materials in parts by weight: 55 parts of pomelo oil, 17 parts of soybean isoflavone, 18 parts of dietary fiber, 13 parts of bifidobacterium, 13 parts of lactobacillus, 10 parts of cyclodextrin, 10 parts of chitosan, 9 parts of peptide powder, 8 parts of soybean lecithin, 8 parts of momordica grosvenori extract and 0.3 part of yeast; the peptide powder is a combination of corn peptide powder and soybean peptide powder according to a mass ratio of 1:1; the dietary fiber is a combination of konjak glucomannan and guar gum with a mass ratio of 1:1; the mass ratio of the chromium-enriched yeast to the magnesium-enriched yeast to the zinc-enriched yeast to the calcium-enriched yeast in the yeast is 1:1:1:1;
the preparation method of the mountain pomelo oil health food capable of assisting in reducing blood sugar comprises the following steps:
s1, preparing a wall material solution: mixing cyclodextrin, soybean lecithin and water, and performing ultrasonic treatment at 200W for 3min to obtain a compound solution A; adding pomelo oil into the composite solution A, stirring and mixing at high speed to obtain emulsion, homogenizing the emulsion at 10MPa for 2 times and 4min each time, then raising the homogenizing pressure to 50MPa for 1 time and 4min each time to obtain emulsion, and spray-drying the emulsion at 170 ℃ of air inlet temperature, 65 ℃ of air outlet temperature, 40Hz of fan frequency and 0.2MPa of atomizing pressure to obtain capsule micropowder A;
s2, adding chitosan into 0.1mol/L acetic acid solution to completely dissolve the chitosan, thereby obtaining chitosan solution; adding the microcapsule powder A, the bifidobacterium, the lactobacillus and the yeast prepared in the step S1 into chitosan solution, stirring and mixing uniformly at a high speed, washing for 3 times by using distilled water, and then freeze-drying to obtain microcapsule powder B;
and S3, uniformly stirring and mixing the microcapsule powder B, the peptide powder, the soybean isoflavone, the dietary fiber and the fructus momordicae extract prepared in the step S2, granulating, and tabletting to obtain the mountain pomelo oil health food capable of assisting in reducing blood sugar.
Example 4
The mountain pomelo oil health food capable of assisting in reducing blood sugar in the implementation is prepared from the following raw materials in parts by weight: 58 parts of pomelo oil, 16 parts of soybean isoflavone, 16 parts of dietary fiber, 14 parts of bifidobacterium, 14 parts of lactobacillus, 12 parts of cyclodextrin, 9 parts of chitosan, 8 parts of peptide powder, 7 parts of soybean lecithin, 9 parts of momordica grosvenori extract and 0.4 part of yeast; the peptide powder is a combination of corn peptide powder, soybean peptide powder and wheat peptide powder according to the mass ratio of 1:1:1; the dietary fiber is a combination of sodium alginate, acacia and guar gum with a mass ratio of 1:1:1; the mass ratio of the chromium-enriched yeast to the magnesium-enriched yeast to the zinc-enriched yeast to the calcium-enriched yeast in the yeast is 1:1:1:1;
the preparation method of the mountain pomelo oil health food capable of assisting in reducing blood sugar comprises the following steps:
s1, preparing a mountain pomelo oil, which comprises the following steps: drying the mountain pomelo seeds in a vacuum dryer at the temperature of 30 ℃ and the vacuum degree of-0.06 MPa to ensure that the water content of the camellia seeds is 5 percent, taking out the camellia seeds, then putting the dried mountain pomelo seeds in a pulverizer for pulverizing for 2 hours to obtain pulverized materials, putting the pulverized materials in a subcritical extractor for extraction, adding an extractant butane, wherein the feed liquid ratio of the pulverized materials to the extractant is 1g:2.0mL, sealing and vacuumizing, setting the extraction temperature at 40 ℃, the pressure at 7.5MPa, the extraction time at 1h, extracting for 2 times, filtering after the extraction is finished, evaporating the filtered extract to obtain pomelo essential oil, centrifuging the pomelo essential oil at 2000r/min for 10min, standing for 2h, and separating to obtain the pomelo oil;
s2, preparing a wall material solution: mixing cyclodextrin, soybean lecithin and water, and performing ultrasonic treatment at 150W for 2min to obtain a compound solution A; adding pomelo oil into the composite solution A, stirring and mixing at high speed to obtain emulsion, homogenizing the emulsion under 15MPa for 1 time, homogenizing for 4.5min each time, raising the homogenizing pressure to 48MPa for 2 times, homogenizing for 3.5min each time to obtain emulsion, and spray-drying the emulsion under the conditions of 165 ℃ of air inlet temperature, 75 ℃ of air outlet temperature, 45Hz of fan frequency and 0.23MPa of atomizing pressure to obtain capsule micropowder A;
s3, adding chitosan into 0.1mol/L acetic acid solution to completely dissolve the chitosan, so as to obtain chitosan solution; adding the microcapsule powder A, the bifidobacterium, the lactobacillus and the yeast prepared in the step S2 into chitosan solution, stirring and mixing uniformly at a high speed, washing for 2 times by using distilled water, and then freeze-drying to obtain microcapsule powder B;
s4, uniformly stirring and mixing the microcapsule powder B, the peptide powder, the soybean isoflavone, the dietary fiber and the fructus momordicae extract prepared in the step S3, granulating, and tabletting to obtain the mountain pomelo oil health food capable of assisting in reducing blood sugar.
Example 5
The mountain pomelo oil health food capable of assisting in reducing blood sugar in the implementation is prepared from the following raw materials in parts by weight: 52 parts of pomelo oil, 18 parts of soybean isoflavone, 17 parts of dietary fiber, 15 parts of bifidobacterium, 12 parts of lactobacillus, 11 parts of cyclodextrin, 11 parts of chitosan, 10 parts of peptide powder, 6 parts of soybean lecithin, 10 parts of momordica grosvenori extract and 0.2 part of yeast; the peptide powder is a combination of corn peptide powder, soybean peptide powder and wheat peptide powder in a ratio of 1:1:1; the dietary fiber is a combination of konjak glucomannan, sodium alginate, acacia, guar gum with a mass ratio of 1:1:1:1; the mass ratio of the chromium-enriched yeast to the magnesium-enriched yeast to the zinc-enriched yeast to the calcium-enriched yeast in the yeast is 1:1:1:1;
the preparation method of the mountain pomelo oil health food capable of assisting in reducing blood sugar comprises the following steps:
s1, preparing a mountain pomelo oil, which comprises the following steps: drying the mountain pomelo seeds in a vacuum dryer at the temperature of 40 ℃ and the vacuum degree of-0.08 MPa to ensure that the water content of the camellia seeds is 6 percent, taking out the camellia seeds, then putting the dried mountain pomelo seeds in a pulverizer for pulverizing for 3 hours to obtain pulverized materials, putting the pulverized materials in a subcritical extractor for extraction, adding an extractant butane, wherein the feed liquid ratio of the pulverized materials to the extractant is 1g:3.0mL, sealing and vacuumizing, setting the extraction temperature to be 50 ℃, the pressure to be 8.0MPa, the extraction time to be 2 hours, extracting for 2 times, filtering after the extraction is finished, evaporating the filtered extract to obtain pomelo essential oil, centrifugally separating the pomelo essential oil at 3000r/min for 12 minutes, standing for 2 hours, and separating to obtain the pomelo oil;
s2, wall material solution: mixing cyclodextrin, soybean lecithin and water, and performing ultrasonic treatment at 180W for 4min to obtain a compound solution A; adding pomelo oil into the composite solution A, stirring and mixing at high speed to obtain emulsion, homogenizing the emulsion at 20MPa for 2 times and 5min each time, then raising the homogenizing pressure to 45MPa for 2 times and 3min each time to obtain emulsion, and spray-drying the emulsion at the air inlet temperature of 160 ℃, the air outlet temperature of 70 ℃, the fan frequency of 40Hz and the atomizing pressure of 0.22MPa to obtain capsule micro powder A;
s3, adding chitosan into 0.1mol/L acetic acid solution to completely dissolve the chitosan, so as to obtain chitosan solution; adding the microcapsule powder A, the bifidobacterium, the lactobacillus and the yeast prepared in the step S2 into chitosan solution, stirring and mixing uniformly at a high speed, washing for 3 times by using distilled water, and then freeze-drying to obtain microcapsule powder B;
s4, uniformly stirring and mixing the microcapsule powder B, the peptide powder, the soybean isoflavone, the dietary fiber and the fructus momordicae extract prepared in the step S3, granulating, and tabletting to obtain the mountain pomelo oil health food capable of assisting in reducing blood sugar.
Comparative example 1
The mountain pomelo oil health food capable of assisting in reducing blood sugar in the implementation is prepared from the following raw materials in parts by weight: 50 parts of soybean oil, 16 parts of soybean isoflavone, 15 parts of dietary fiber, 12 parts of bifidobacterium, 10 parts of lactobacillus, 10 parts of cyclodextrin, 8 parts of chitosan, 8 parts of corn peptide powder, 6 parts of soybean lecithin, 8 parts of momordica grosvenori extract and 0.1 part of yeast; the dietary fiber is a combination of konjak glucomannan and sodium alginate in a mass ratio of 1:1; the mass ratio of the chromium-enriched yeast to the magnesium-enriched yeast to the zinc-enriched yeast to the calcium-enriched yeast in the yeast is 1:1:1:1;
the preparation method of the health food comprises the following steps: soybean oil, soybean isoflavone, dietary fiber, bifidobacterium, lactobacillus, cyclodextrin, chitosan, corn peptide powder, soybean lecithin, fructus momordicae extract and yeast are taken, stirred and mixed uniformly, and granulated and tabletted to obtain the health food.
In this comparative example, the grapefruit oil was replaced with soybean oil as compared with example 1.
Comparative example 2
The mountain pomelo oil health food capable of assisting in reducing blood sugar in the implementation is prepared from the following raw materials in parts by weight: 50 parts of corn oil, 16 parts of mulberry leaf flavone, 15 parts of dietary fiber, 12 parts of bifidobacterium, 10 parts of lactobacillus, 10 parts of cyclodextrin, 8 parts of chitosan, 8 parts of corn peptide powder, 6 parts of soybean lecithin, 8 parts of momordica grosvenori extract and 0.1 part of yeast; the dietary fiber is a combination of konjak glucomannan and sodium alginate in a mass ratio of 1:1; the mass ratio of the chromium-enriched yeast to the magnesium-enriched yeast to the zinc-enriched yeast to the calcium-enriched yeast in the yeast is 1:1:1:1;
the preparation method of the health food comprises the following steps: mixing corn oil, mulberry leaf flavone, dietary fiber, bifidobacterium, lactobacillus, cyclodextrin, chitosan, soybean lecithin, fructus momordicae extract and yeast, stirring, granulating, and tabletting to obtain health food.
In this comparative example, corn oil and mulberry leaf brass ingredients were added, and grapefruit oil and soybean isoflavone ingredients were not contained, as compared with example 1.
Comparative example 3
The mountain pomelo oil health food capable of assisting in reducing blood sugar in the implementation is prepared from the following raw materials in parts by weight: 16 parts of soybean isoflavone, 15 parts of dietary fiber, 10 parts of cyclodextrin, 8 parts of chitosan, 8 parts of corn peptide powder, 6 parts of soybean lecithin, 8 parts of momordica grosvenori extract and 0.1 part of yeast; the dietary fiber is a combination of konjak glucomannan and sodium alginate in a mass ratio of 1:1; the mass ratio of the chromium-enriched yeast to the magnesium-enriched yeast to the zinc-enriched yeast to the calcium-enriched yeast in the yeast is 1:1:1:1;
the preparation method of the health food comprises the following steps: mixing oleum Rapae, soybean isoflavone, dietary fiber, cyclodextrin, chitosan, corn peptide powder, soybean lecithin, fructus Siraitiae Grosvenorii extract and yeast, stirring, granulating, and tabletting to obtain health food.
In comparison with example 1, the comparative example does not contain grapefruit oil, bifidobacteria, and lactic acid bacteria.
Experimental conditions:
1. experimental animal model establishment
150 SPF-grade, C57BL/6J, male mice were purchased, weighing 20+ -2 g; the mice are fed for 7d to adapt to the animal, the feeding environment is 50-60% of constant humidity, and the animal house with the constant temperature of 20-25 ℃ circulates for 12 hours, so that the mice can drink water and eat freely; 10 mice were randomly drawn 7d later as a blank group.
(1) And (3) establishing a model: tetraoxypyrimidine (0.2 g/kg) was injected from the abdominal cavity into the remaining 140 mice as model group mice, and after 5 hours of injection, glucose solution with concentration of 50% was infused into the stomach of the mice, and after 72 hours of injection, blood was taken from the tail vein of the mice to measure fasting blood glucose content, and when the blood glucose content value was > 11.1mmol/L, it was shown that the model establishment was successful.
(2) Experiment design: randomly selecting 100 mice successfully molded, and randomly dividing the mice into 10 groups of 10 mice each;
groups 1 to 5 are the mountain pomelo oil health food prepared by the embodiments 1 to 5 of the invention for stomach irrigation;
groups 6 to 8 were subjected to stomach lavage using the pomelo oil health food prepared in comparative examples 1 to 3;
group 9 was intragastric with metformin hydrochloride as a positive control;
the 10 th group adopts normal saline to irrigate the stomach as a model group;
the blank group adopts normal saline to irrigate the stomach as a negative control group;
the weight of the stomach filling proportion is 1000mg/kg, the stomach filling volume is 0.1ml/10g, the stomach filling time is 10:00 am every day, and the mice are given the same drinking water and diet every day, so that the mice can drink water and diet normally, the experiment is carried out for 4 weeks,
(3) Experimental determination of index
The fur, the urine and the mental state of the mice are observed every day, the water intake and the diet of the mice are recorded, and the fasting blood glucose content value of the mice is measured every 10 days;
when the experiment is finished, the mice are sacrificed, kidneys, spleens and livers of the mice are taken out, blood stains on the surfaces of the mice are cleaned by ice-cold normal saline, the mice are wiped dry after the mice are cleaned, the total weight of three organs is recorded respectively, and the organ indexes are calculated, wherein the organ indexes = organ mass (g)/body weight (g) of the mice;
weighing 0.5g of liver, preparing into 10% liver homogenate by using normal saline, centrifuging at 4deg.C and rotation speed of 2000r/min for 12min, and taking supernatant to test CAT and MDA indexes in the liver according to the instruction of the kit.
The experimental conditions are shown in tables 1 and 2 below.
Table 1 mice drinking water diet experiment conditions
TABLE 2 blood glucose level, organ index, CAT and MDA index of mice
The above results show that, by daily observation of mice in the negative control group and the model group, the mice in the model group were found to be listless, slow in response, thin in hair, reduced in weight, and the like, while urination was increased, and a polydipsia and polyphagia phenomenon was also observed, and by the gastric lavage and dry prognosis of the shan pomelo oil health food prepared in examples 1 to 5 and comparative examples 1 to 3 and the hypoglycemic drug metformin hydrochloride, the weight of the mice began to rise, and the mental state was improved, the reaction was slightly faster, the fur tended to be normal, the gloss was slightly felt, and in the gastric lavage process, the shan pomelo oil health food prepared in examples 1 to 5 of the invention was found to be able to improve the hyperglycemia symptoms of diabetic mice. Diabetes mellitus also causes damage to organs such as liver, kidney and spleen, hypertrophy and lipid increase of the organs, and experiments show that the pomelo oil prepared by the embodiment 1-5 can reduce the organs to different degrees and reduce oxidative stress, so that the pomelo oil prepared by the invention has good auxiliary blood sugar reducing effect.
The foregoing description of the preferred embodiments of the invention is not intended to be limiting, but rather is intended to cover all modifications, equivalents, alternatives, and improvements that fall within the spirit and scope of the invention.
Claims (8)
1. The mountain pomelo oil health food capable of assisting in reducing blood sugar is characterized by comprising the following raw materials in parts by weight: 50-60 parts of pomelo oil, 16-18 parts of soybean isoflavone, 15-20 parts of dietary fiber, 12-15 parts of bifidobacterium, 10-15 parts of lactobacillus, 10-12 parts of cyclodextrin, 8-12 parts of chitosan, 8-10 parts of peptide powder, 6-8 parts of soybean lecithin, 8-10 parts of momordica grosvenori extract and 0.1-0.5 part of yeast;
the peptide powder is one or the combination of more than two of corn peptide powder, soybean peptide powder and wheat peptide powder;
the yeast consists of chromium-enriched yeast, magnesium-enriched yeast, zinc-enriched yeast and calcium-enriched yeast.
2. The method for preparing the grapefruit oil health-care food capable of assisting in reducing blood sugar according to claim 1, wherein the dietary fiber is one or a combination of more than two of konjak glucomannan, sodium alginate, acacia and guar gum.
3. The preparation of the shan pomelo oil health food capable of assisting in reducing blood sugar according to claim 1, wherein the mass ratio of the chromium-enriched yeast to the magnesium-enriched yeast to the zinc-enriched yeast to the calcium-enriched yeast is 1:1:1:1.
4. The preparation method of the shan pomelo oil health food capable of assisting in reducing blood sugar according to claim 1, which is characterized in that the preparation method of the shan pomelo oil comprises the following steps: and (3) drying the pomelo seeds in a vacuum dryer to ensure that the water content of the camellia seeds is 5-6%, taking out, crushing in a crusher to obtain crushed materials, putting the crushed materials in a subcritical extractor, adding an extractant butane for sealed vacuum extraction, filtering after extraction is finished, and centrifugally separating filtrate to obtain the pomelo oil.
5. The preparation of the shan pomelo oil health food capable of assisting in reducing blood sugar according to claim 4, wherein the drying conditions in the vacuum dryer are as follows: the temperature is 30-50 ℃, the vacuum degree is minus 0.06-minus 0.09MPa, and the extraction conditions in the subcritical extractor are as follows: the extraction temperature is 40-50 ℃, the pressure is 7.5-9.0 MPa, the extraction time is 1-3 h, and the extraction is 2-3 times; the centrifugal separation conditions are as follows: setting the rotating speed at 2000-3000 r/min, centrifuging for 10-15 min, standing for 2-3 h and separating.
6. The method for preparing the shan pomelo oil health food capable of assisting in reducing blood sugar according to any one of claims 1 to 5, which is characterized by comprising the following steps:
s1, preparing a wall material solution: mixing cyclodextrin, soybean lecithin and water, and performing ultrasonic treatment at 100-200W for 2-4 min to prepare a compound solution A; adding pomelo oil into the composite solution A, stirring and mixing at high speed to obtain emulsion, homogenizing the emulsion at high pressure to obtain emulsion, and spray drying to obtain capsule micropowder A;
s2, adding chitosan into 0.1mol/L acetic acid solution to completely dissolve the chitosan, thereby obtaining chitosan solution; adding the microcapsule powder A, the bifidobacterium, the lactobacillus and the yeast prepared in the step S1 into chitosan solution, stirring and mixing uniformly at a high speed, washing for 2-3 times by using distilled water, and then freeze-drying to obtain microcapsule powder B;
and S3, uniformly stirring and mixing the microcapsule powder B, the peptide powder, the soybean isoflavone, the dietary fiber and the fructus momordicae extract prepared in the step S2, granulating, and tabletting to obtain the mountain pomelo oil health food capable of assisting in reducing blood sugar.
7. The method for preparing the shan pomelo oil health food capable of assisting in reducing blood sugar according to claim 6, wherein the spray drying conditions are as follows: the air inlet temperature is 160-170 ℃, the air outlet temperature is 60-80 ℃, the fan frequency is 40-45 Hz, and the atomization pressure is 0.2-0.25 MPa.
8. The method for preparing the shan pomelo oil health food capable of assisting in reducing blood sugar according to claim 6, wherein the high-pressure homogenizing condition is that the mountain pomelo oil health food is homogenized for 1-2 times under 10-20 MPa for 4-5 min each time, and then the homogenizing pressure is raised to 40-50 MPa for 1-2 times for 3-4 min each time.
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