CN116763835A - Production method for reducing ochratoxin A in licorice extract - Google Patents
Production method for reducing ochratoxin A in licorice extract Download PDFInfo
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- CN116763835A CN116763835A CN202310556470.5A CN202310556470A CN116763835A CN 116763835 A CN116763835 A CN 116763835A CN 202310556470 A CN202310556470 A CN 202310556470A CN 116763835 A CN116763835 A CN 116763835A
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- licorice
- licorice extract
- ochratoxin
- water
- extraction
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- 229940069445 licorice extract Drugs 0.000 title claims abstract description 27
- VYLQGYLYRQKMFU-UHFFFAOYSA-N Ochratoxin A Natural products CC1Cc2c(Cl)cc(CNC(Cc3ccccc3)C(=O)O)cc2C(=O)O1 VYLQGYLYRQKMFU-UHFFFAOYSA-N 0.000 title claims abstract description 22
- RWQKHEORZBHNRI-BMIGLBTASA-N ochratoxin A Chemical compound C([C@H](NC(=O)C1=CC(Cl)=C2C[C@H](OC(=O)C2=C1O)C)C(O)=O)C1=CC=CC=C1 RWQKHEORZBHNRI-BMIGLBTASA-N 0.000 title claims abstract description 22
- DAEYIVCTQUFNTM-UHFFFAOYSA-N ochratoxin B Natural products OC1=C2C(=O)OC(C)CC2=CC=C1C(=O)NC(C(O)=O)CC1=CC=CC=C1 DAEYIVCTQUFNTM-UHFFFAOYSA-N 0.000 title claims abstract description 22
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 12
- 238000003756 stirring Methods 0.000 claims abstract description 12
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 31
- 238000000605 extraction Methods 0.000 claims description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 27
- 239000000706 filtrate Substances 0.000 claims description 25
- 238000001914 filtration Methods 0.000 claims description 25
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 20
- 235000011477 liquorice Nutrition 0.000 claims description 20
- 238000002156 mixing Methods 0.000 claims description 15
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 claims description 6
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 claims description 6
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 229940010454 licorice Drugs 0.000 claims description 6
- 238000004140 cleaning Methods 0.000 claims description 5
- 239000012535 impurity Substances 0.000 claims description 5
- 229930183344 ochratoxin Natural products 0.000 claims description 5
- 241000202807 Glycyrrhiza Species 0.000 claims 4
- 238000001179 sorption measurement Methods 0.000 abstract description 7
- 238000003809 water extraction Methods 0.000 abstract description 2
- 235000017443 Hedysarum boreale Nutrition 0.000 description 5
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 5
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000001514 detection method Methods 0.000 description 3
- 241000228212 Aspergillus Species 0.000 description 2
- 231100000678 Mycotoxin Toxicity 0.000 description 2
- 241000228143 Penicillium Species 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000002636 mycotoxin Substances 0.000 description 2
- 229930195730 Aflatoxin Natural products 0.000 description 1
- 239000005409 aflatoxin Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/13—Preparation or pretreatment of starting material involving cleaning, e.g. washing or peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Extraction Or Liquid Replacement (AREA)
Abstract
The invention discloses a production method for reducing ochratoxin A in licorice extract, and relates to the technical field of licorice extract processing. The method for producing the licorice extract comprises the steps of carrying out stirring adsorption treatment twice on the extracting solution obtained after three times of water extraction treatment, and then concentrating and stir-frying the extracting solution to obtain a high-quality licorice extract product. The ochratoxin A in the licorice extract is lower than 160 mug/kg.
Description
Technical Field
The invention belongs to the technical field of licorice extract processing, and particularly relates to a production method for reducing ochratoxin A in licorice extract.
Background
Ochratoxins are yet another mycotoxins that have attracted worldwide attention following aflatoxins. It is an important group of mycotoxins that pollute food products produced by 7 aspergillus species of aspergillus and 6 penicillium species of penicillium. Ochratoxin A has the advantages of large toxicity, wide distribution, high yield, serious pollution to agricultural products and serious influence on human health.
The problem that the content of ochratoxin A exceeds standard is easily caused in the processing process of the licorice extract, so that how to adjust the processing technology of the licorice extract to reduce the content of the ochratoxin A is a hot spot of current research.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a production method for reducing ochratoxin A in licorice extract, which can obviously reduce the content of ochratoxin A in the licorice extract.
The invention is realized by adopting the following technical scheme:
a production method for reducing ochratoxin A in licorice extract comprises the following steps:
step one, cleaning liquorice to remove surface impurities;
shredding the cleaned liquorice to obtain liquorice shreds;
step three, primary extraction:
mixing and decocting radix Glycyrrhizae with water at 90deg.C for 120min, and filtering to obtain extractive solution and residue;
step four, secondary extraction:
mixing the filter residue after primary extraction with water, decocting at 90deg.C for 120min, and filtering to obtain extractive solution and filter residue;
fifth, three times of extraction:
mixing the filter residue after the secondary extraction with water, then decocting at 90 ℃ for 120min, and filtering to obtain an extracting solution and filter residue;
step six, combining the three extracting solutions;
step seven, adding diatomite into the combined extracting solution for stirring and adsorbing treatment, and collecting filtrate after filtering; preferably, the adsorption time is 30min;
step eight, adding active carbon into the filtrate in the step seven, stirring and adsorbing, and collecting the filtrate after filtering; preferably, the adsorption time is 20min;
step nine, concentrating the filtrate collected in the step eight to obtain a concentrated solution with the Baume degree not lower than 18;
step ten, preliminary stir-frying the concentrated solution to obtain concentrated solution with the water content of 45% -50%;
and step eleven, continuously stir-frying the concentrated solution after preliminary stir-frying to obtain the liquorice extract with the moisture content of less than 13.5%.
Preferably, in the second step, the width of the licorice root filaments is smaller than 5cm.
Preferably, in the third step, the weight ratio of the licorice root filaments to the water is 1:3-10.
Preferably, the weight ratio of the filter residue after primary extraction in the step four to water is 1:3-8.
Preferably, the weight ratio of the filter residue after the secondary extraction in the step five to water is 1:3-8.
Preferably, the adding amount of diatomite in the step seven accounts for 3-5% of the mass of the extracting solution.
Preferably, the addition amount of the active carbon in the step eight accounts for 0.5-1.5% of the mass of the filtrate.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a production method for reducing ochratoxin A in licorice extractum, which comprises the steps of carrying out stirring adsorption treatment twice on an extracting solution obtained after three times of water extraction treatment, and then concentrating and stir-frying to obtain a high-quality licorice extractum product. The ochratoxin A in the licorice extract is lower than 160 mug/kg.
Detailed Description
The invention will be further illustrated with reference to specific examples.
Example 1
A production method for reducing ochratoxin A in licorice extract comprises the following specific steps:
step one, cleaning liquorice to remove surface impurities;
shredding the cleaned liquorice to obtain liquorice shreds with the width of 2.0 cm;
step three, primary extraction:
mixing and decocting the licorice root shreds and water according to the weight ratio of 1:6, wherein the decoction temperature is 90 ℃, the decoction time is 120min, and filtering to obtain a collected extract and filter residues;
step four, secondary extraction:
mixing the filter residue after primary extraction with water according to the weight ratio of 1:5, then decocting at 90 ℃ for 120min, and filtering to obtain a collected extract and filter residue;
fifth, three times of extraction:
mixing the filter residue after the secondary extraction with water according to the weight ratio of 1:5, then decocting at 90 ℃ for 120min, and filtering to obtain a collected extract and filter residue;
step six, combining the three extracting solutions;
step seven, adding diatomite accounting for 3.4% of the mass of the extracting solution into the combined extracting solution, and stirring and adsorbing for 30min; filtering and collecting filtrate; preferably, the adsorption time is 30min;
step eight, adding active carbon accounting for 0.8% of the mass of the filtrate into the filtrate in the step seven, stirring and adsorbing for 20min, and filtering and collecting the filtrate;
step nine, concentrating the filtrate collected in the step eight to obtain a concentrated solution with the Baume degree of 19.5;
step ten, primarily stir-frying the concentrated solution to obtain concentrated solution with the water content of 48.5%;
and step eleven, continuously stir-frying the concentrated solution after preliminary stir-frying to obtain the liquorice extract with the water content of 12.3 percent.
Through detection, the content of ochratoxin A in the licorice extract product is 149 mug/kg.
Example 2
A production method for reducing ochratoxin A in licorice extract comprises the following specific steps:
step one, cleaning liquorice to remove surface impurities;
step two, crushing the cleaned liquorice to obtain liquorice shreds with the width of 3.0 cm;
step three, primary extraction:
mixing and decocting the licorice root shreds and water according to the weight ratio of 1:6, wherein the decoction temperature is 90 ℃, the decoction time is 120min, and filtering to obtain a collected extract and filter residues;
step four, secondary extraction:
mixing the filter residue after primary extraction with water according to the weight ratio of 1:5, then decocting at 90 ℃ for 120min, and filtering to obtain a collected extract and filter residue;
fifth, three times of extraction:
mixing the filter residue after the secondary extraction with water according to the weight ratio of 1:5, then decocting at 90 ℃ for 120min, and filtering to obtain a collected extract and filter residue;
step six, combining the three extracting solutions;
step seven, adding diatomite accounting for 4% of the mass of the extracting solution into the combined extracting solution, and stirring and adsorbing for 30min; filtering and collecting filtrate; preferably, the adsorption time is 30min;
step eight, adding active carbon accounting for 1% of the mass of the filtrate into the filtrate in the step seven, stirring and adsorbing for 20min, and filtering and then collecting the filtrate;
step nine, concentrating the filtrate collected in the step eight to obtain a concentrated solution with the Baume degree of 19.5;
step ten, primarily stir-frying the concentrated solution to obtain concentrated solution with the water content of 48.2%;
and step eleven, continuously stir-frying the concentrated solution after preliminary stir-frying to obtain the liquorice extract with the water content of 12.0%.
Through detection, the content of ochratoxin A in the licorice extract product is 142 mug/kg.
Example 3
A production method for reducing ochratoxin A in licorice extract comprises the following specific steps:
step one, cleaning liquorice to remove surface impurities;
step two, crushing the cleaned liquorice to obtain liquorice shreds with the width of 4.2 cm;
step three, primary extraction:
mixing and decocting the licorice root shreds and water according to the weight ratio of 1:6, wherein the decoction temperature is 90 ℃, the decoction time is 120min, and filtering to obtain a collected extract and filter residues;
step four, secondary extraction:
mixing the filter residue after primary extraction with water according to the weight ratio of 1:5, then decocting at 90 ℃ for 120min, and filtering to obtain a collected extract and filter residue;
fifth, three times of extraction:
mixing the filter residue after the secondary extraction with water according to the weight ratio of 1:5, then decocting at 90 ℃ for 120min, and filtering to obtain a collected extract and filter residue;
step six, combining the three extracting solutions;
step seven, adding diatomite accounting for 5% of the mass of the extracting solution into the combined extracting solution, and stirring and adsorbing for 30min; filtering and collecting filtrate; preferably, the adsorption time is 30min;
step eight, adding active carbon accounting for 1.5% of the mass of the filtrate into the filtrate in the step seven, stirring and adsorbing for 20min, and filtering and collecting the filtrate;
step nine, concentrating the filtrate collected in the step eight to obtain a concentrated solution with the Baume degree of 18.8;
step ten, primarily stir-frying the concentrated solution to obtain concentrated solution with the water content of 45.6%;
and step eleven, continuously stir-frying the concentrated solution after preliminary stir-frying to obtain the liquorice extract with the water content of 11.8%.
Through detection, the content of ochratoxin A in the licorice extract product is 140 mug/kg.
It should be noted that the above-mentioned embodiments are only a few specific embodiments of the present invention, and it is obvious that the present invention is not limited to the above embodiments, but other modifications are possible. All modifications directly or indirectly derived from the disclosure of the present invention will be considered to be within the scope of the present invention.
Claims (7)
1. A production method for reducing ochratoxin A in licorice extract is characterized by comprising the following steps:
step one, cleaning liquorice to remove surface impurities;
shredding the cleaned liquorice to obtain liquorice shreds;
step three, primary extraction:
mixing and decocting radix Glycyrrhizae with water at 90deg.C for 120min, and filtering to obtain extractive solution and residue;
step four, secondary extraction:
mixing the filter residue after primary extraction with water, decocting at 90deg.C for 120min, and filtering to obtain extractive solution and filter residue;
fifth, three times of extraction:
mixing the filter residue after the secondary extraction with water, then decocting at 90 ℃ for 120min, and filtering to obtain an extracting solution and filter residue;
step six, combining the three extracting solutions;
step seven, adding diatomite into the combined extracting solution for stirring and adsorbing treatment, and collecting filtrate after filtering;
step eight, adding active carbon into the filtrate in the step seven, stirring and adsorbing, and collecting the filtrate after filtering;
step nine, concentrating the filtrate collected in the step eight to obtain a concentrated solution with the Baume degree not lower than 18;
step ten, preliminary stir-frying the concentrated solution to obtain concentrated solution with the water content of 45% -50%;
and step eleven, continuously stir-frying the concentrated solution after preliminary stir-frying to obtain the liquorice extract with the moisture content of less than 13.5%.
2. The method for reducing ochratoxin a in licorice extract according to claim 1, wherein the second licorice filaments are licorice filaments having a width of less than 5cm.
3. The method for reducing ochratoxin a in licorice extract according to claim 1, wherein the weight ratio of licorice filaments to water in the third step is 1:3-10.
4. The method for reducing ochratoxin A in licorice extractum according to claim 1, wherein the weight ratio of the filter residue after one extraction in the fourth step to water is 1:3-8.
5. The method for reducing ochratoxin A in licorice extract according to claim 1, wherein the weight ratio of the filter residue after the second extraction in the fifth step to water is 1:3-8.
6. The method for reducing ochratoxin a in licorice extract according to claim 1, wherein the diatomite is added in an amount of 3% -5% of the mass of the extract in the seventh step.
7. The method for reducing ochratoxin a in licorice extract according to claim 1, wherein the amount of activated carbon added in the step eight is 0.5% -1.5% of the mass of the filtrate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310556470.5A CN116763835A (en) | 2023-05-17 | 2023-05-17 | Production method for reducing ochratoxin A in licorice extract |
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| CN202310556470.5A CN116763835A (en) | 2023-05-17 | 2023-05-17 | Production method for reducing ochratoxin A in licorice extract |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104730172A (en) * | 2013-12-20 | 2015-06-24 | 中国医学科学院药用植物研究所 | New purification method and testing technology of ochratoxin A in traditional Chinese medicines |
| CN113804803A (en) * | 2021-06-28 | 2021-12-17 | 乌鲁木齐海关技术中心 | Rapid determination method suitable for glycyrrhiza uralensis paste ochratoxin A |
| CN114796305A (en) * | 2022-05-09 | 2022-07-29 | 新疆富沃药业有限公司 | Preparation method and application of licorice extract |
-
2023
- 2023-05-17 CN CN202310556470.5A patent/CN116763835A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104730172A (en) * | 2013-12-20 | 2015-06-24 | 中国医学科学院药用植物研究所 | New purification method and testing technology of ochratoxin A in traditional Chinese medicines |
| CN113804803A (en) * | 2021-06-28 | 2021-12-17 | 乌鲁木齐海关技术中心 | Rapid determination method suitable for glycyrrhiza uralensis paste ochratoxin A |
| CN114796305A (en) * | 2022-05-09 | 2022-07-29 | 新疆富沃药业有限公司 | Preparation method and application of licorice extract |
Non-Patent Citations (2)
| Title |
|---|
| 国家药典委员会: "《中华人民共和国药典：2020年版.一部》", 31 May 2020, 中国医药科技出版社, pages: 418 * |
| 王君玮，张喜悦主译: "《食源性疾病 1》", vol. 3, 31 December 2021, 北京：中国轻工业出版社, pages: 341 * |
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