CN116747273A - 一种护肝解酒口服液及其制备工艺 - Google Patents
一种护肝解酒口服液及其制备工艺 Download PDFInfo
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- CN116747273A CN116747273A CN202310808554.3A CN202310808554A CN116747273A CN 116747273 A CN116747273 A CN 116747273A CN 202310808554 A CN202310808554 A CN 202310808554A CN 116747273 A CN116747273 A CN 116747273A
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Abstract
本发明涉及保健品技术领域，尤其涉及一种护肝解酒口服液及其制备工艺。包括如下原料：丹参、白芍、当归、川芎、灵芝、葛根、葛根花、枳椇子、柴胡、菊花、桑葚、五味子、黄芪、茯苓、山楂、泽泻、苦参、柴胡、半夏、甘草、人参、冬虫夏草、赤芍、陈皮。制备工艺包括如下步骤：将原料按比例混合，放入药包中；用清水冲洗药包，再将药包放入容器中用水煮沸，转中火慢炖；将汤药倒出，通过纱布进行过滤，得到药液；向药液中加入食用酒精调和、加入冰糖和蜂蜜调味，并搅拌均匀，即得口服液；最后将口服液瓶装，密封保存于冰箱内，随时饮用。本发明的目的是为了解决上述技术问题，提出一种无副作用、吸收好的护肝解酒口服液及其制备工艺。
Description
技术领域
本发明涉及保健品技术领域，尤其涉及一种护肝解酒口服液及其制备工艺。
背景技术
肝，人体五脏之一，是脊椎动物身体内以代谢功能为主的一个器官，并在身体里面扮演着去氧化，储存肝糖，分泌性蛋白质的合成等等角色，同时肝脏也制造消化系统中之胆汁；中医认为：肝与胆相为表里，开窍于目，肝主藏血，肝主疏泄，有贮藏和调节血液的功能；因此对于肝的保护和养护及其重要。
目前，市场上解酒护肝的保健品其解酒的原理大都是分解酒精浓度，尽管还有部分厂家在解酒药在里面添加了利尿剂、兴奋剂、激素等，这些成份人吃了以后短时间内会感到清醒、亢奋、食欲大开，但其副作用较大，长期服用将伤及身体；且其功效较为有限，仅仅是能缓解酒精浓度够高造成的头晕、呕吐等症状，对肝的保护作用不大。
发明内容
本发明的目的是为了解决上述技术问题，提出一种无副作用、吸收好的护肝解酒口服液及其制备工艺。
本发明所采用的技术方案为：一种护肝解酒口服液，包括如下原料，其原料按重量份数计数：丹参占12-15份、白芍占15-18份、当归占10-15份、川芎占12-18份、灵芝占12-15份、葛根占18-24份、葛根花占15-20份、枳椇子占12-18份、柴胡占8-12份、菊花占6-10份、桑葚占9-12份、五味子占3-5份、黄芪占12-15份、茯苓占8-12份、山楂占8-15份、泽泻占8-12份、苦参占6-8份、柴胡占1-3份、半夏占6-9份、甘草占6-8份、人参占10-15份、冬虫夏草占5-8份、赤芍占2-5份、陈皮占2-4份。
作为本发明进一步的改进，所述原料按重量份数计数的最优选：丹参占14份、白芍占16份、当归占12份、川芎占15份、灵芝占13份、葛根占20份、葛根花占18份、枳椇子占15份、柴胡占10份、菊花占8份、桑葚占10份、五味子占4份、黄芪占13份、茯苓占10份、山楂占12份、泽泻占10份、苦参占7份、柴胡占2份、半夏占8份、甘草占7份、人参占12份、冬虫夏草占6份、赤芍占4份、陈皮占3份。
一种护肝解酒口服液制备工艺，包括以下制备工艺，其制备工艺包括如下步骤：
步骤一：将丹参、白芍、当归、川芎、灵芝、葛根、葛根花、枳椇子、柴胡、菊花、桑葚、五味子、黄芪、茯苓、山楂、泽泻、苦参、柴胡、半夏、甘草、人参、冬虫夏草、赤芍、陈皮按比例混合，放入药包中；
步骤二：用清水冲洗药包，去除原料表面的灰尘，然后再将药包放入容器中用水煮沸，转中火炖2-4小时；
步骤三：将药包取出并挤压出残留汤药，待冷却后，将容器中炖好的汤药倒出，通过纱布进行过滤，得到药液；
步骤四：向药液中加入食用酒精调和、加入冰糖和蜂蜜调味，并搅拌均匀，即得口服液；
步骤五：最后将口服液瓶装，密封保存于冰箱内，随时饮用。
作为本发明进一步的改进，所述水与原料总量的比例为3-6:1，所述食用酒精与原料总量的比例为1:40-58，所述冰糖和蜂蜜总量与原料总量的比例为1:20-30。
本发明的有益效果：本发明通过24味中药组合制备而成，在用量的调配上令各味中药之间的药效相辅相成，相得益彰，使得本发明不仅易吸收、无副作用，并且具有养肝护肝的作用，同时解酒功效显著。
具体实施方式
为了使本申请所要解决的技术问题、技术方案及有益效果更加清楚明白，以下结合实施例，对本申请进行进一步详细说明。应当理解，此处所描述的实施例仅仅用以解释本申请，并不用于限定本申请。
本发明提供了一种护肝解酒口服液，包括如下原料，其原料按重量份数计数：丹参占12-15份、白芍占15-18份、当归占10-15份、川芎占12-18份、灵芝占12-15份、葛根占18-24份、葛根花占15-20份、枳椇子占12-18份、柴胡占8-12份、菊花占6-10份、桑葚占9-12份、五味子占3-5份、黄芪占12-15份、茯苓占8-12份、山楂占8-15份、泽泻占8-12份、苦参占6-8份、柴胡占1-3份、半夏占6-9份、甘草占6-8份、人参占10-15份、冬虫夏草占5-8份、赤芍占2-5份、陈皮占2-4份。
本发明中所述原料按重量份数计数的最优选：丹参占14份、白芍占16份、当归占12份、川芎占15份、灵芝占13份、葛根占20份、葛根花占18份、枳椇子占15份、柴胡占10份、菊花占8份、桑葚占10份、五味子占4份、黄芪占13份、茯苓占10份、山楂占12份、泽泻占10份、苦参占7份、柴胡占2份、半夏占8份、甘草占7份、人参占12份、冬虫夏草占6份、赤芍占4份、陈皮占3份。
一种护肝解酒口服液制备工艺，包括以下制备工艺，其制备工艺包括如下步骤：
步骤一：将丹参、白芍、当归、川芎、灵芝、葛根、葛根花、枳椇子、柴胡、菊花、桑葚、五味子、黄芪、茯苓、山楂、泽泻、苦参、柴胡、半夏、甘草、人参、冬虫夏草、赤芍、陈皮按比例混合，放入药包中；
步骤二：用清水冲洗药包，去除原料表面的灰尘，然后再将药包放入容器中用水煮沸，转中火炖2-4小时；
步骤三：将药包取出并挤压出残留汤药，待冷却后，将容器中炖好的汤药倒出，通过纱布进行过滤，得到药液；
步骤四：向药液中加入食用酒精调和、加入冰糖和蜂蜜调味，并搅拌均匀，即得口服液；
步骤五：最后将口服液瓶装，密封保存于冰箱内，随时饮用。
本发明中所述原料总量与水的比例为1:3-6，所述食用酒精与原料总量的比例为1:40-58，所述冰糖和蜂蜜总量与原料总量的比例为1:20-30。
实施例1：
将14份丹参、16份白芍、12份当归、15份川芎、13份灵芝、20份葛根、18份葛根花、15份枳椇子、10份柴胡、8份菊花、10份桑葚、4份五味子、13份黄芪、10份茯苓、12份山楂、10份泽泻、7份苦参、2份柴胡、8份半夏、7份甘草、12份人参、6份冬虫夏草、4份赤芍、3份陈皮混合，放入药包中；用清水冲洗药包，去除原料表面的灰尘，然后再将药包放入容器中用1000份水煮沸，转中火炖3小时；将药包取出并挤压出残留汤药，待冷却后，将容器中炖好的汤药倒出，通过纱布进行过滤，得到药液；向药液中加入5份食用酒精调和、加入10份冰糖和蜂蜜调味，并搅拌均匀，即得口服液；最后将口服液瓶装，密封保存于冰箱内，随时饮用。
实验：
1.选择48只患酒精性肝病的Wistar雄性大鼠；
2.将大鼠随机分为对照组、模型组、样本对照组、样本对照组，每组12只；
3.饮食相同，其中对照组灌等体积生理盐水，模型组灌等体积酒精，连续10天；
4.最后一次给口服液后禁食不禁水12小时，其中对照组、模型组、样本对照组服用实施例1所得口服液，样本对照组服用市面上常规的解酒类护肝口服液；
5.测定大鼠全血中的乙醇含量，留取血清及肝组织标本，检测相关指标：(1)血清ALT、AST活性；(2)血清及肝组织丙二醇(MDA)活性测定；(3)脂质过氧化指标：肝脏中还原型谷胱甘肽(GSH-Px)含量。结果如下表：
可以发现本实施例1所得口服液可以显著降低AST、ALT、MDA的活性，并升高血清GSH-Px的水平，能够起到较好的缓解和保护酒精性肝损伤的作用。
实施例2：
将14份丹参、17份白芍、13份当归、15份川芎、13份灵芝、22份葛根、18份葛根花、15份枳椇子、10份柴胡、10份菊花、10份桑葚、4份五味子、14份黄芪、10份茯苓、12份山楂、10份泽泻、7份苦参、2份柴胡、8份半夏、7份甘草、12份人参、6份冬虫夏草、4份赤芍、3份陈皮混合，放入药包中；用清水冲洗药包，去除原料表面的灰尘，然后再将药包放入容器中用800份水煮沸，转中火炖2.5小时；将药包取出并挤压出残留汤药，待冷却后，将容器中炖好的汤药倒出，通过纱布进行过滤，得到药液；向药液中加入5份食用酒精调和、加入9份冰糖和蜂蜜调味，并搅拌均匀，即得口服液；最后将口服液瓶装，密封保存于冰箱内，随时饮用。
实验：
1.选择48只患酒精性肝病的Wistar雄性大鼠；
2.将大鼠随机分为对照组、模型组、样本对照组、样本对照组，每组12只；
3.饮食相同，其中对照组灌等体积生理盐水，模型组灌等体积酒精，连续10天；
4.最后一次给口服液后禁食不禁水12小时，其中对照组、模型组、样本对照组服用实施例2所得口服液，样本对照组服用市面上常规的解酒类护肝口服液；
5.测定大鼠全血中的乙醇含量，留取血清及肝组织标本，检测相关指标：(1)血清ALT、AST活性；(2)血清及肝组织丙二醇(MDA)活性测定；(3)脂质过氧化指标：肝脏中还原型谷胱甘肽(GSH-Px)含量。结果如下表：
可以发现本实施例2口服液可以显著降低AST、ALT、MDA的活性，并升高血清GSH-Px的水平，能够起到较好的缓解和保护酒精性肝损伤的作用。
实施例3：
将15份丹参、17份白芍、14份当归、16份川芎、14份灵芝、22份葛根、18份葛根花、16份枳椇子、10份柴胡、9份菊花、10份桑葚、4份五味子、14份黄芪、10份茯苓、14份山楂、10份泽泻、8份苦参、2份柴胡、8份半夏、7份甘草、14份人参、7份冬虫夏草、4份赤芍、3份陈皮混合，放入药包中；用清水冲洗药包，去除原料表面的灰尘，然后再将药包放入容器中用1200份水煮沸，转中火炖3.5小时；将药包取出并挤压出残留汤药，待冷却后，将容器中炖好的汤药倒出，通过纱布进行过滤，得到药液；向药液中加入6份食用酒精调和、加入12份冰糖和蜂蜜调味，并搅拌均匀，即得口服液；最后将口服液瓶装，密封保存于冰箱内，随时饮用。
实验：
1.选择48只患酒精性肝病的Wistar雄性大鼠；
2.将大鼠随机分为对照组、模型组、样本对照组、样本对照组，每组12只；
3.饮食相同，其中对照组灌等体积生理盐水，模型组灌等体积酒精，连续10天；
4.最后一次给口服液后禁食不禁水12小时，其中对照组、模型组、样本对照组服用实施例3所得口服液，样本对照组服用市面上常规的解酒类护肝口服液；
5.测定大鼠全血中的乙醇含量，留取血清及肝组织标本，检测相关指标：(1)血清ALT、AST活性；(2)血清及肝组织丙二醇(MDA)活性测定；(3)脂质过氧化指标：肝脏中还原型谷胱甘肽(GSH-Px)含量。结果如下表：
可以发现本实施例3口服液可以显著降低AST、ALT、MDA的活性，并升高血清GSH-Px的水平，能够起到较好的缓解和保护酒精性肝损伤的作用。
以上实施例仅用以说明本发明的技术方案，而非对其限制；尽管参照前述实施例对本发明进行了详细的说明，本领域的普通技术人员应当理解：其依然可以对前述实施例所记载的技术方案进行修改，或者对其中部分技术特征进行等同替换；而这些修改或者替换，并不使相应技术方案的本质脱离本发明实施例技术方案的精神和范围。
Claims (4)
1.一种护肝解酒口服液，其特征在于：包括如下原料，其原料按重量份数计数：丹参占12-15份、白芍占15-18份、当归占10-15份、川芎占12-18份、灵芝占12-15份、葛根占18-24份、葛根花占15-20份、枳椇子占12-18份、柴胡占8-12份、菊花占6-10份、桑葚占9-12份、五味子占3-5份、黄芪占12-15份、茯苓占8-12份、山楂占8-15份、泽泻占8-12份、苦参占6-8份、柴胡占1-3份、半夏占6-9份、甘草占6-8份、人参占10-15份、冬虫夏草占5-8份、赤芍占2-5份、陈皮占2-4份。
2.根据权利要求1所述的一种护肝解酒口服液，其特征在于：所述原料按重量份数计数的最优选：丹参占14份、白芍占16份、当归占12份、川芎占15份、灵芝占13份、葛根占20份、葛根花占18份、枳椇子占15份、柴胡占10份、菊花占8份、桑葚占10份、五味子占4份、黄芪占13份、茯苓占10份、山楂占12份、泽泻占10份、苦参占7份、柴胡占2份、半夏占8份、甘草占7份、人参占12份、冬虫夏草占6份、赤芍占4份、陈皮占3份。
3.一种护肝解酒口服液制备工艺，其特征在于：包括以下制备工艺，其制备工艺包括如下步骤：
步骤一：将丹参、白芍、当归、川芎、灵芝、葛根、葛根花、枳椇子、柴胡、菊花、桑葚、五味子、黄芪、茯苓、山楂、泽泻、苦参、柴胡、半夏、甘草、人参、冬虫夏草、赤芍、陈皮按比例混合，放入药包中；
步骤二：用清水冲洗药包，去除原料表面的灰尘，然后再将药包放入容器中用水煮沸，转中火炖2-4小时；
步骤三：将药包取出并挤压出残留汤药，待冷却后，将容器中炖好的汤药倒出，通过纱布进行过滤，得到药液；
步骤四：向药液中加入食用酒精调和、加入冰糖和蜂蜜调味，并搅拌均匀，即得口服液；
步骤五：最后将口服液瓶装，密封保存于冰箱内，随时饮用。
4.根据权利要求3所述的一种护肝解酒口服液制备工艺，其特征在于：所述原料总量与水的比例为1:3-6，所述食用酒精与原料总量的比例为1:40-58，所述冰糖和蜂蜜总量与原料总量的比例为1:20-30。
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