CN116747011B - Radio frequency ablation system for ablating biological tissues - Google Patents
Radio frequency ablation system for ablating biological tissues Download PDFInfo
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- CN116747011B CN116747011B CN202310732236.3A CN202310732236A CN116747011B CN 116747011 B CN116747011 B CN 116747011B CN 202310732236 A CN202310732236 A CN 202310732236A CN 116747011 B CN116747011 B CN 116747011B
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- 238000007674 radiofrequency ablation Methods 0.000 title claims abstract description 91
- 238000004804 winding Methods 0.000 claims abstract description 80
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- 229920002530 polyetherether ketone Polymers 0.000 claims abstract description 39
- 238000010438 heat treatment Methods 0.000 claims abstract description 26
- 238000001514 detection method Methods 0.000 claims abstract description 16
- 239000002994 raw material Substances 0.000 claims abstract description 5
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 18
- 238000006243 chemical reaction Methods 0.000 claims description 15
- 239000012065 filter cake Substances 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 6
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 6
- 239000011259 mixed solution Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- 239000000243 solution Substances 0.000 claims description 6
- 229940126062 Compound A Drugs 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 4
- 229910021641 deionized water Inorganic materials 0.000 claims description 4
- 239000012279 sodium borohydride Substances 0.000 claims description 4
- 229910000033 sodium borohydride Inorganic materials 0.000 claims description 4
- 238000000967 suction filtration Methods 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 3
- 238000001132 ultrasonic dispersion Methods 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 3
- 230000006872 improvement Effects 0.000 description 18
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- 239000000463 material Substances 0.000 description 11
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
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- 239000003795 chemical substances by application Substances 0.000 description 3
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- 206010028980 Neoplasm Diseases 0.000 description 2
- 239000004677 Nylon Substances 0.000 description 2
- 239000004809 Teflon Substances 0.000 description 2
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- 230000006750 UV protection Effects 0.000 description 2
- 238000002679 ablation Methods 0.000 description 2
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- 206010031264 Osteonecrosis Diseases 0.000 description 1
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- 230000002745 absorbent Effects 0.000 description 1
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- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical group [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
- 235000013539 calcium stearate Nutrition 0.000 description 1
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- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- MGNCLNQXLYJVJD-UHFFFAOYSA-N cyanuric chloride Chemical compound ClC1=NC(Cl)=NC(Cl)=N1 MGNCLNQXLYJVJD-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
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- 238000002386 leaching Methods 0.000 description 1
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- -1 polyethylene Polymers 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L61/00—Compositions of condensation polymers of aldehydes or ketones; Compositions of derivatives of such polymers
- C08L61/04—Condensation polymers of aldehydes or ketones with phenols only
- C08L61/16—Condensation polymers of aldehydes or ketones with phenols only of ketones with phenols
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/06—Control, e.g. of temperature, of power
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/02—Induction heating
- H05B6/36—Coil arrangements
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2205/00—Polymer mixtures characterised by other features
- C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
- C08L2205/025—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group containing two or more polymers of the same hierarchy C08L, and differing only in parameters such as density, comonomer content, molecular weight, structure
Abstract
The invention provides a radio frequency ablation system for ablating biological tissues, which comprises a radio frequency ablation control device and a radio frequency ablation catheter; the radio frequency ablation control device comprises: the temperature detection unit is connected with the radio frequency ablation catheter and is used for detecting the working temperature of the radio frequency ablation catheter; the temperature control unit is connected between the temperature detection unit and the radio frequency ablation catheter and used for controlling the working temperature of the radio frequency ablation catheter; the radio frequency ablation catheter comprises a heating body containing a winding carrier tube; wherein, the raw materials for preparing the winding carrier tube comprise polyether-ether-ketone and modified polyether-ether-ketone. The radio frequency ablation control device provided by the application controls the radio frequency ablation catheter (long-time storage) after ultraviolet disinfection to work without being limited by temperature and time, and has good safety performance.
Description
Technical Field
The invention belongs to the technical field of radio frequency medical equipment, and particularly relates to a radio frequency ablation system for ablating biological tissues.
Background
The radio frequency ablation system has the functions of ablation and cutting, when radio frequency current flows through human tissues, water molecules with polarity in the tissues move at a high speed due to the rapid change of an electromagnetic field, heat is generated, and the water inside and outside the cells is evaporated, dried, condensed and shed so as to cause aseptic necrosis, thereby achieving the purpose of treatment. Because the technology has small trauma to human body, and the ablation mode can be accurately controlled by an electronic system, the technology is widely used for heart, cancer tumor and other focus tissues in recent years.
The radio frequency ablation system comprises a radio frequency ablation catheter and a radio frequency ablation control device, the radio frequency ablation control device precisely controls windings on the radio frequency ablation catheter through an electronic system to generate controllable heat through radio frequency current, and the radio frequency ablation control device can heat the vascular wall and then shrink the vascular wall to achieve a treatment effect. When the winding is used, if the winding carrier tube is not used, the winding not only can reduce the stability of the winding due to the lack of the support of the winding carrier tube, but also can directly transmit the generated heat to the connecting inner tube due to the lack of the winding carrier tube, so that the heat influence is generated on the connecting inner tube.
In the prior art, when the winding and the winding carrier tube are matched for use, the winding carrier tube is prepared from polyether-ether-ketone materials for ensuring that the winding carrier tube has the characteristics of high temperature resistance, impact resistance, wear resistance and the like, but because the radio frequency ablation catheter is applied to the medical field, ultraviolet disinfection needs to be carried out for a long time, the winding carrier tube irradiated by ultraviolet rays has poor ultraviolet resistance, when the winding carrier tube is heated at high temperature, the winding carrier tube can have the condition of cracks, in order to solve the problem of poor ultraviolet resistance of the polyether-ether-ketone, when the winding carrier tube is prepared, an ultraviolet absorber is added into the polyether-ether-ketone, but because the polyether-ether-ketone is high in viscosity and easy to agglomerate, the mechanical property of the winding carrier tube is reduced when the winding carrier tube is stored for a long time, and when the radio frequency ablation catheter is controlled to work, the radio frequency ablation control device controls the temperature and the time of the radio frequency ablation catheter to be limited because the mechanical property of the winding carrier tube is low.
Aiming at the problems existing in the prior art, how to provide a radio frequency ablation system for ablating biological tissues, when a radio frequency ablation control device controls a radio frequency ablation catheter stored for a long time to work, the radio frequency ablation system is not limited by the working temperature and time, and the radio frequency ablation system is a problem to be solved in the invention.
Disclosure of Invention
The present invention aims to provide a radiofrequency ablation system for ablating biological tissue, which solves the problems set forth in the background art.
In order to achieve the above purpose, the present invention provides the following technical solutions:
a radio frequency ablation system for ablating biological tissue, comprising: comprises a radio frequency ablation control device and a radio frequency ablation catheter;
the radio frequency ablation control device comprises:
the temperature detection unit is connected with the radio frequency ablation catheter and is used for detecting the working temperature of the radio frequency ablation catheter;
the temperature control unit is connected between the temperature detection unit and the radio frequency ablation catheter and used for controlling the working temperature of the radio frequency ablation catheter;
the radio frequency ablation catheter comprises a heating body containing a winding carrier tube; wherein, the raw materials for preparing the winding carrier tube comprise polyether-ether-ketone and modified polyether-ether-ketone.
As a further improvement, the radio frequency ablation control device further includes:
the power conversion unit is connected between the temperature control unit and the radio frequency ablation catheter and used for adjusting the working power of the radio frequency ablation catheter.
As a further improvement, the radio frequency ablation control device further includes:
and the man-machine control interface is connected with the temperature control unit and is used for setting control parameters of the temperature control unit.
As a further improvement, the radio frequency ablation catheter comprises a heating assembly, a handle, a connecting main pipe and a connecting inner pipe, wherein the heating assembly is connected with the handle through the connecting main pipe, the heating assembly further comprises an outer pipe positioned outside the heating body, the heating body further comprises a winding which is wound on the outer wall of the winding carrier pipe, the outer wall of the outer pipe is slidably connected with a rubber ring, the connecting inner pipe is positioned on the inner side of the winding carrier pipe, the connecting inner pipe sequentially penetrates through the inner parts of the connecting main pipe and the outer pipe, and the winding is electrically connected with the power conversion unit.
As a further improvement, two rubber rings are provided.
As a further improvement, the mass ratio of the polyether-ether-ketone to the modified polyether-ether-ketone is 1: (0.2-0.6).
As a further improvement, the preparation of the modified polyether ether ketone comprises the following steps:
(1) Adding sodium carbonate solution into a reactor to enable the pH value in the reactor to be 8-10, then adding a compound of a compound A and N, N-dimethylformamide, uniformly mixing, and setting the temperature to be 60-80 ℃;
(2) Adding the hydroxylated polyether-ether-ketone into N, N-dimethylformamide, and performing ultrasonic dispersion at 45-70 ℃ for 10-30min to prepare a mixed solution;
(3) And (3) dropwise adding the mixed solution obtained in the step (2) into the step (1), keeping the temperature at 60-80 ℃ after the dropwise adding, continuing to react for 40-60min, and performing post-treatment to obtain the modified polyether-ether-ketone.
As a further improvement, the preparation of the hydroxylated polyetheretherketone comprises the following steps:
and (3) reacting polyether-ether-ketone, sodium borohydride and dimethyl sulfoxide at 110-135 ℃ for 5-15 hours, performing suction filtration to obtain a filter cake, washing the filter cake with absolute ethyl alcohol, deionized water and hydrochloric acid in sequence, and drying the washed filter cake to obtain the hydroxylated polyether-ether-ketone.
As a further improvement, in step (3), the molar ratio of the compound a to the hydroxylated polyetheretherketone is 1: (2-2.5).
As a further improvement, the mass ratio of the polyether-ether-ketone to the sodium borohydride is (3-5): 1.
As a further improvement, the heating assembly further comprises a sealing plug clamped with the inner side of the outer tube, the sealing plug and the connecting main tube are positioned on two sides of the outer tube, and one end of the winding carrier tube is fixedly connected with the sealing plug.
As a further improvement, the heating assembly further comprises a sealing plug clamped with the inner side of the outer tube, the sealing plug is located close to one side of the connecting main tube, one end of the winding carrier tube is fixedly connected with the sealing plug, a temperature sensor is mounted on the winding carrier tube, and one end of the connecting inner tube penetrates through the sealing plug.
As a further improvement, the winding carrier tube further comprises a connecting tube positioned between the connecting inner tube and the winding carrier tube, one end of the connecting tube is fixedly connected with the sealing plug, and the connecting tube and the winding carrier tube are made of the same material.
As a further improvement, the connecting main pipe material includes, but is not limited to, nylon, teflon, polyether ether ketone, polyimide, etc.
The outer tube material can be ultraviolet-proof material or ultraviolet-proof material, wherein the ultraviolet-proof material comprises but is not limited to Teflon, ABS, PC and the like, and the ultraviolet-proof material comprises but is not limited to acrylic, PE, PEA and the like.
As a further improvement, the resistance value of the winding is 50-300 omega-m.
As a further improvement, the temperature detection unit comprises a temperature sensor mounted on the winding carrier tube close to the winding.
As a further improvement, the temperature detection unit further includes:
the analog-to-digital conversion unit is connected between the temperature sensor and the temperature control unit and is used for converting analog signals acquired by the temperature sensor into digital signals.
As a further improvement, the temperature sensor is a thermocouple or a thermal resistor.
As a further improvement, the handle is respectively provided with a luer connector connected with the connecting inner tube and a button switch for controlling the winding to work.
Compared with the prior art, the invention has the beneficial effects that: when the radio frequency ablation control device controls the radio frequency ablation catheter (stored for a long time) after ultraviolet disinfection to work, the radio frequency ablation control device is not limited by the working temperature and time, and has good safety performance;
in addition, when the radio frequency ablation catheter provided by the application works at high temperature, the winding carrier tube still has good resistance to rapid crack growth and slow crack growth.
Drawings
FIG. 1 is a functional block diagram of a data processing system for a radiofrequency ablation system for ablating biological tissue in accordance with the present invention;
FIG. 2 is a schematic diagram of the overall structure of a radiofrequency ablation catheter according to the present invention;
FIG. 3 is an enlarged view of FIG. 2A in accordance with the present invention;
FIG. 4 is a schematic view of a heating element according to the present invention.
In the figure: the device comprises a 1-heating component, a 11-outer tube, a 14-heating body, a 141-winding, a 142-winding carrier tube, a 2-handle, a 3-connecting main tube, a 4-connecting inner tube, a 5-rubber ring, a 7-button switch, an 8-luer connector, a 10-radio frequency ablation control device, a 101-man-machine control interface, a 102-temperature control unit, a 103-power conversion unit, a 104-temperature detection unit, a 1041-analog-to-digital conversion unit, a 1042-temperature sensor and a 20-radio frequency ablation catheter.
Detailed Description
The present invention is further illustrated in the following drawings and detailed description, which are to be understood as being merely illustrative of the invention and not limiting the scope of the invention.
Referring to fig. 1, a radio frequency ablation system for ablating biological tissue includes a radio frequency ablation control device 10 and a radio frequency ablation catheter 20; the radio frequency ablation control device 10 includes: a temperature detection unit 104, wherein the temperature detection unit 104 is connected with the radio frequency ablation catheter 20 and is used for detecting the working temperature of the radio frequency ablation catheter 20; a temperature control unit 102, wherein the temperature control unit 102 is connected between the temperature detection unit 104 and the radio frequency ablation catheter 20, and is used for controlling the working temperature of the radio frequency ablation catheter 20; the radiofrequency ablation catheter 20 includes a heating body including a winding carrier tube 142; wherein, the raw materials for preparing the winding carrier tube comprise polyether-ether-ketone and modified polyether-ether-ketone;
wherein the radio frequency ablation control device 10 further comprises: a power conversion unit 103, wherein the power conversion unit 103 is connected between the temperature control unit 102 and the radio frequency ablation catheter 20 and is used for adjusting the working power of the radio frequency ablation catheter 20;
the radio frequency ablation control device 10 further comprises: a man-machine control interface 101, wherein the man-machine control interface 101 is connected with the temperature control unit 102 and is used for setting control parameters of the temperature control unit 102;
the temperature detection unit 104 includes a temperature sensor 1042, the temperature sensor 1042 is mounted on the winding carrier tube 142 near the winding 141, and the temperature sensor 1042 is a thermocouple or a thermal resistor.
The temperature detection unit 104 further includes:
the analog-to-digital conversion unit 1041, the analog-to-digital conversion unit 1041 is connected between the temperature sensor 1042 and the temperature control unit 102, and is used for converting the analog signal collected by the temperature sensor 1042 into a digital signal.
Referring to fig. 2-4, the radio frequency ablation catheter 20 includes a heating assembly 1, a handle 2, a connection main pipe 3, and a connection inner pipe 4, the heating assembly 1 is connected to the handle 2 through the connection main pipe 3, the heating assembly 1 further includes an outer pipe 11 located outside the heating body 14, the heating body 14 further includes a winding 141 wound around an outer wall of the winding carrier pipe 142, the outer wall of the outer pipe 11 is slidably connected with a rubber ring 5, the connection inner pipe 4 is located inside the winding carrier pipe 142, the connection inner pipe 4 sequentially passes through the connection main pipe 3 and the inner pipe 11, the winding 141 is electrically connected with the power conversion unit 103, two rubber rings 5 are provided, and luer connectors 8 connected with the connection inner pipe 4 and a button switch 7 for controlling the winding 141 to work are respectively provided on the handle 2; the heating assembly further comprises a sealing plug clamped with the inner side of the outer tube, the sealing plug is positioned on one side close to the connecting main tube, one end of the winding carrier tube is fixedly connected with the sealing plug, and one end of the connecting inner tube penetrates through the sealing plug; the connecting tube is positioned between the connecting inner tube and the winding carrier tube, one end of the connecting tube is fixedly connected with the sealing plug, and the connecting tube and the winding carrier tube are made of the same material.
Wherein, the preparation of the winding carrier tube 142 comprises the following steps:
(1) Preparation of Compound A:
cyanuric chloride (available from Zhengzhou full-enriched chemical products Co., ltd.) was added to a three-necked flask
0.014mol and 20mL of acetone are stirred and swelled for 10min under ice bath condition, then 0.007mol of ultraviolet absorbent UV-O (purchased from Wohamik biomedical technology Co.) and 0.011mol of NaOH are respectively dissolved in 15mL of acetone and 50mL of distilled water, after the two solutions are uniformly mixed, the mixture is slowly added into a three-neck flask, the mixture is reacted for 5h at 0 ℃ to generate light yellow powdery precipitate, the filter cake is respectively washed with distilled water and absolute ethyl alcohol for two times, finally the filter cake is dried, and the filter cake is separated and purified by a column chromatography method (the leaching agent is ethyl acetate and petroleum ether, and the volume ratio of the ethyl acetate to the petroleum ether is l: 7) to prepare the compound A.
(2) Preparing hydroxylated polyether-ether-ketone:
1kg of polyether-ether-ketone (purchased from Shanghai such as Ind/Ind Co., ltd., trade name: 150FC 30), 0.2kg of sodium borohydride and 20mL of dimethyl sulfoxide are reacted at 120 ℃ for 10 hours, and suction filtration is carried out to obtain a filter cake, the filter cake is washed by absolute ethyl alcohol, deionized water and hydrochloric acid in sequence, and the washed filter cake is dried in an oven at 75 ℃ for 15 hours to obtain the hydroxylated polyether-ether-ketone.
(3) Preparing modified polyether-ether-ketone:
(3.1) adding 70mL of sodium carbonate solution into the reactor to make the pH in the reactor be 9, then adding 1mol of compound A and 20mol of N, N-dimethylformamide solution, uniformly mixing, and setting the temperature to be 70 ℃;
(3.2) adding 2.2mol of hydroxylated polyether-ether-ketone into 15mol of N, N-dimethylformamide, and performing ultrasonic dispersion at 60 ℃ for 30min to prepare a mixed solution;
and (3.3) dropwise adding the mixed solution obtained in the step (3.2) into the step (3.1), keeping the temperature at 70 ℃ after the dropwise addition, continuing to react for 50min, adding hydrochloric acid with the concentration of 36% until ph is 7, washing the mixture with absolute ethyl alcohol and deionized water in sequence, carrying out suction filtration on the obtained substance to obtain a primary filter cake, and carrying out vacuum drying on the filter cake at 50 ℃ for 12h to obtain the modified polyether ether ketone.
(4) Winding carrier tube 142 is prepared (all raw materials for preparing winding carrier tube 142 need to be dried, and the drying condition is that the drying temperature is 150 ℃ and the drying time is 4 hours):
(4.1) heating the mould to be used to 150 ℃, and preserving heat for 2 hours, wherein the upper and lower working surfaces of the mould are coated with a release agent, and the release agent is calcium stearate;
(4.2) weighing 1kg of polyether-ether-ketone and 0.3kg of modified polyether-ether-ketone, uniformly stirring (stirring speed is 40r/min, stirring time is 10 min), placing into the die treated in the step (4.1), and then placing into a press to be pressurized to 700kg/cm 2 Maintaining the pressure for 2 minutes;
(4.3) placing the die in the step (4.2) into a sintering furnace, wherein the temperature of the sintering furnace is set to be 400 ℃, and the placing time is set to be 8 hours;
(4.4) the mold of step (4.3) was rapidly taken out and placed on a press, cooled for 10 minutes, and then pressurized to 500kg/cm 2 Maintaining the pressure for 18 minutes;
(4.5) cooling the die treated in the step (4.4) to 200 ℃ and then demoulding to obtain the winding carrier tube 142.
(5) Assembling the radiofrequency ablation catheter 20:
winding 141 around the outer wall of the prepared winding carrier tube 142, fixedly connecting one end of the winding carrier tube 142 with the side surface of the sealing plug, clamping the sealing plug on the inner side of the outer tube 11 (the outer tube is made of PE (polyethylene) material, the PE material is purchased from Shanghai derivative plasticizing limited company, the mark is 1600J, the outer tube is prepared by a conventional method), enabling the connecting inner tube to penetrate through the connecting main tube 3 (the connecting main tube is made of nylon), fixedly connecting two ends of the connecting main tube 3 with the handle 2 and the outer tube 11 respectively after the sealing plug is used, winding the cable on the winding 141 into the connecting main tube 3, winding the cable on the winding 141 out through the handle, and then connecting the cable with the radio frequency ablation control device 10 to assemble the radio frequency ablation catheter 20.
Working principle: the temperature sensor 1042 is installed on the winding carrier tube 142 near the winding 141, and then the temperature sensor 1042 is used for setting parameters of the temperature control unit 102 through the man-machine control interface 101, the button switch 7 controls the winding 141 to work, the temperature sensor 1042 transmits the collected temperature signal to the analog-digital conversion unit 1041, the analog-digital conversion unit 1041 converts the received temperature signal into a digital signal and transmits the digital signal to the temperature control unit 102, the temperature control unit 102 controls the temperature of the winding 141, and the winding 141 reaches the set temperature and maintains for a certain time (for example, 2h, etc.), and then the human diseases are treated.
Wherein, the temperature of the winding is controlled to 120 ℃ by using a temperature control unit 102, and after the winding is electrified for 48 hours, the performance test (the test standard is a small-size steady-state test (S4 test) for measuring the rapid crack growth Resistance (RCP) of the thermoplastic plastic pipe for fluid conveying in GB/T19280-2003 and a test method (notch test) for measuring the slow crack growth resistance of the notch pipe for measuring the crack growth resistance of the polyolefin pipe for fluid conveying in GB/T18976-2001) of the winding carrier pipe 142 is carried out, and the measured rapid crack growth resistance is more than 0.5MPa, and the slow crack growth resistance is more than 200 hours.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the spirit and scope of the invention as defined by the appended claims and their equivalents, it being apparent that the described embodiments of the invention are only some of the embodiments of the invention and not all the embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Claims (8)
1. A radio frequency ablation system for ablating biological tissue, comprising: comprises a radio frequency ablation control device and a radio frequency ablation catheter;
the radio frequency ablation control device comprises:
the temperature detection unit is connected with the radio frequency ablation catheter and is used for detecting the working temperature of the radio frequency ablation catheter;
the temperature control unit is connected between the temperature detection unit and the radio frequency ablation catheter and used for controlling the working temperature of the radio frequency ablation catheter;
the radio frequency ablation catheter comprises a heating body containing a winding carrier tube; wherein, the raw materials for preparing the winding carrier tube comprise polyether-ether-ketone and modified polyether-ether-ketone;
the preparation of the modified polyether-ether-ketone comprises the following steps:
(1) Adding sodium carbonate solution into a reactor to enable the pH value in the reactor to be 8-10, then adding a compound of a compound A and N, N-dimethylformamide, uniformly mixing, and setting the temperature to be 60-80 ℃;
A
(2) Adding the hydroxylated polyether-ether-ketone into N, N-dimethylformamide, and performing ultrasonic dispersion at 45-70 ℃ for 10-30min to prepare a mixed solution;
(3) Dropwise adding the mixed solution obtained in the step (2) into the step (1), keeping the temperature at 60-80 ℃ after the dropwise adding, continuing to react for 40-60min, and performing post-treatment to obtain modified polyether-ether-ketone;
the preparation of the hydroxylated polyether-ether-ketone comprises the following steps:
and (3) reacting polyether-ether-ketone, sodium borohydride and dimethyl sulfoxide at 110-135 ℃ for 5-15 hours, performing suction filtration to obtain a filter cake, washing the filter cake with absolute ethyl alcohol, deionized water and hydrochloric acid in sequence, and drying the washed filter cake to obtain the hydroxylated polyether-ether-ketone.
2. A radio frequency ablation system for ablating biological tissue according to claim 1, wherein: the radio frequency ablation control device further comprises:
the power conversion unit is connected between the temperature control unit and the radio frequency ablation catheter and used for adjusting the working power of the radio frequency ablation catheter.
3. A radio frequency ablation system for ablating biological tissue according to claim 2, wherein: the radio frequency ablation control device further comprises:
and the man-machine control interface is connected with the temperature control unit and is used for setting control parameters of the temperature control unit.
4. A radio frequency ablation system for ablating biological tissue according to claim 1, wherein: the radio frequency ablation catheter comprises a heating assembly, a handle, a connecting main pipe and a connecting inner pipe, wherein the heating assembly is connected with the handle through the connecting main pipe, the heating assembly further comprises an outer pipe positioned outside the heating body, the heating body further comprises a winding which is connected with the outer wall of the winding carrying pipe in a winding mode, the outer wall of the outer pipe is connected with a rubber ring in a sliding mode, the connecting inner pipe is positioned on the inner side of the winding carrying pipe, the connecting inner pipe sequentially penetrates through the inner parts of the connecting main pipe and the outer pipe, and the winding is electrically connected with the power conversion unit.
5. A radio frequency ablation system for ablating biological tissue according to claim 4, wherein: the mass ratio of the polyether-ether-ketone to the modified polyether-ether-ketone is 1: (0.2-0.6).
6. A radio frequency ablation system for ablating biological tissue according to claim 1, wherein: the temperature detection unit comprises a temperature sensor, wherein the temperature sensor is arranged on a winding carrier tube close to the winding, and the temperature sensor is a thermocouple or a thermal resistor.
7. A radio frequency ablation system for ablating biological tissue according to claim 6, wherein: the temperature detection unit further includes:
the analog-to-digital conversion unit is connected between the temperature sensor and the temperature control unit and is used for converting analog signals acquired by the temperature sensor into digital signals.
8. A radio frequency ablation system for ablating biological tissue according to claim 6, wherein: the handles are respectively provided with a luer connector connected with the connecting inner tube and a button switch for controlling the winding to work.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101442950A (en) * | 2006-05-16 | 2009-05-27 | 圣朱德医疗有限公司房颤分公司 | Ablation electrode assembly and methods for improved controlof temperature |
| CN111943831A (en) * | 2020-08-18 | 2020-11-17 | 山东非金属材料研究所 | Preparation method of polyether-ether-ketone oligomer with high flame retardance |
| CN214017796U (en) * | 2020-10-15 | 2021-08-24 | 昆山雷盛医疗科技有限公司 | Flexible blood vessel ablation catheter |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6932813B2 (en) * | 2002-05-03 | 2005-08-23 | Scimed Life Systems, Inc. | Ablation systems including insulated energy transmitting elements |
| US10327830B2 (en) * | 2015-04-01 | 2019-06-25 | Monteris Medical Corporation | Cryotherapy, thermal therapy, temperature modulation therapy, and probe apparatus therefor |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101442950A (en) * | 2006-05-16 | 2009-05-27 | 圣朱德医疗有限公司房颤分公司 | Ablation electrode assembly and methods for improved controlof temperature |
| CN111943831A (en) * | 2020-08-18 | 2020-11-17 | 山东非金属材料研究所 | Preparation method of polyether-ether-ketone oligomer with high flame retardance |
| CN214017796U (en) * | 2020-10-15 | 2021-08-24 | 昆山雷盛医疗科技有限公司 | Flexible blood vessel ablation catheter |
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