CN104496459A - Nano-hydroxyapatite ceramic and preparation method thereof - Google Patents
Nano-hydroxyapatite ceramic and preparation method thereof Download PDFInfo
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- CN104496459A CN104496459A CN201410713067.XA CN201410713067A CN104496459A CN 104496459 A CN104496459 A CN 104496459A CN 201410713067 A CN201410713067 A CN 201410713067A CN 104496459 A CN104496459 A CN 104496459A
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Abstract
The invention relates to a nano-hydroxyapatite ceramic and a preparation method thereof and belongs to the technical field of ceramic processing. The nano-hydroxyapatite ceramic is prepared from the following components in parts by weight: 20-50 parts of hydroxyapatite, 40-60 parts of Al2O3, 10-20 parts of CaO, 1-10 parts of ZrO2, 1-10 parts of Y2O3 and 1-10 parts of CaF2. The preparation method of the nano-hydroxyapatite ceramic comprises the following steps of: matching the components according to a proportion, adding an alcohol solution, mixing uniformly, kneading, evaporating a solvent in a water bath at the temperature of 80 DEG C, heating to expand in a drying oven at the temperature of 70-90 DEG C, molding, putting the molded blank into a muffle furnace, increasing the temperature of the muffle furnace to 1,000-1,200 DEG C slowly, treating the blank for 8-10 hours, cooling, and taking out of the muffle furnace to obtain a finished product of the nano-hydroxyapatite ceramic. The nano-hydroxyapatite ceramic provided by the invention is a three-dimensional nano-porous expanded product, has the porosity of 90% or higher and is suitable for scaffold materials and bone repair materials in the bone tissue engineering.
Description
Technical field
The present invention relates to a kind of pottery and preparation method thereof, be specifically related to a kind of Nano-grained Hydroxyapatite Ceramics material and preparation method thereof, belong to ceramic processing technique field.
Background technology
Since nearly half a century people hanker after biological ceramics sclerous tissues research major cause be: the operation wound of (1) autologous bone transplanting and possible complication; (2) the potential disease infection risk of allogenic bone transplantation; (3) find that osseous tissue can organically combine with the biological ceramics of some calcics; (4) development of biological ceramics technology of preparing.Hydroxyapatite is the main inorganic composition of skeleton, it is the biological active materials that a class has good biocompatibility, after implantable bone tissue, chemical bonding that can be very strong with bone forming on interface, having bone conduction and osteoinductive, is therefore one of important thing of implantable bioartificial stupalith research.The thermostability of nanometer hydroxyapatite directly affects mechanical property and the biological functionality of stupalith, therefore, and one of factor study hotspot becoming this field affecting nanometer hydroxyapatite thermostability.
Performance and the grain-size of stupalith are closely related, and the size of crystal grain is relevant to the particle diameter of material powder, so the preparation of powder seems particularly important.The preparation method of current hydroxyapatite mainly contains: the method such as Hydrothermal Synthesis, sol-gel, solid state reaction, co-precipitation, mechanochemistry ball milling.Since Gedye and Giguere in 1986 etc. report household microwave oven for the synthesis of organism since, microwave because of can improve chemical reaction speed of response, under certain conditions can inhibited reaction carrying out and change reaction approach, easy and simple to handle, by product is few, productive rate is high and the advantage such as save energy makes microwave-assisted synthesis be developed rapidly.Present microwave is widely used in from inorganic reaction to organic reaction, from medication chemistry to food chemistry, and the fields such as the vital process from simple molecules to complexity.But the report of the high temperatures nano-hydroxy-apatite of preparation is also few both at home and abroad.
The mechanical property of tradition hydroxylapatite ceramic is poor, such as, the not super 1.0MPa.m1/2 of fracture toughness property (KIC), poor as its work reliability of artificial growth body.Up to the present, HAP pottery can not be used as supportive implant, and its application is medically only limitted to the stephanoporate implant of powder, coating and low carrying.Nano-biological cerimic is little due to crystal grain, the inherent pore in material or defect size is greatly reduced, not easily causes transgranular fracture, and is conducive to the fracture toughness property improving material; Meanwhile, the refinement of crystal grain makes again number of grain boundaries greatly increase, and contributes to intercrystalline slippage, makes nano-biological cerimic show the mechanical properties such as unique superplasticity.
201310148908.2 disclose a kind of by hydroxyapatite nano rod or sheet build porous nano pottery and preparation method, the method carries out nanometer by hydrothermal method to phosphoric acid DFP porous ceramics, obtains the porous nano pottery built by hydroxyapatite nano rod or nanometer sheet; But the requirement of the method to equipment is higher, thus this patent is existed, and one-time investment is high, product cost is difficult to the problems such as reduction; The present invention is with hydroxyapatite, Al
2o
3, CaO, ZrO
2, Y
2o
3, CaF
2deng being raw material, obtained Nano-grained Hydroxyapatite Ceramics has higher biological activity, and improves its degradation property, and preparation method is simple, and repeatability is high, can large-scale production.
Summary of the invention
The object of this invention is to provide a kind of Nano-grained Hydroxyapatite Ceramics, this Nano-grained Hydroxyapatite Ceramics has higher biological activity, and improves its degradation property, and preparation method is simple, and repeatability is high, can large-scale production.
In order to solve the problem, the technical solution adopted in the present invention is:
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 20 ~ 50 parts, Al
2o
340 ~ 60 parts, CaO 10 ~ 20 parts, ZrO
21 ~ 10 part, Y
2o
31 ~ 10 part, CaF
21 ~ 10 part.
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 25 ~ 30 parts, Al
2o
340 ~ 45 parts, CaO 15 ~ 20 parts, ZrO
22 ~ 3 parts, Y
2o
32 ~ 4 parts, CaF
24 ~ 5 parts.
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 30 ~ 35 parts, Al
2o
345 ~ 50 parts, CaO 10 ~ 15 parts, ZrO
25 ~ 6 parts, Y
2o
36 ~ 8 parts, CaF
22 ~ 3 parts.
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 35 ~ 40 parts, Al
2o
350 ~ 55 parts, CaO 15 ~ 18 parts, ZrO
26 ~ 8 parts, Y
2o
38 ~ 9 parts, CaF
22 ~ 3 parts.
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 40 ~ 45 parts, Al
2o
355 ~ 60 parts, CaO 18 ~ 20 parts, ZrO
28 ~ 10 parts, Y
2o
38 ~ 10 parts, CaF
24 ~ 6 parts.
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 45 ~ 50 parts, Al
2o
340 ~ 55 parts, CaO 10 ~ 14 parts, ZrO
22 ~ 5 parts, Y
2o
36 ~ 7 parts, CaF
25 ~ 8 parts.
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 30 ~ 40 parts, Al
2o
340 ~ 50 parts, CaO 10 ~ 15 parts, ZrO
26 ~ 7 parts, Y
2o
37 ~ 8 parts, CaF
23 ~ 5 parts.
A preparation method for Nano-grained Hydroxyapatite Ceramics, comprises the steps:
After said components is prepared burden in proportion, add appropriate alcoholic solution and carry out Homogeneous phase mixing, kneading, then evaporating solvent in 80 DEG C of water-baths, to heat in the baking oven of 70 ~ 90 DEG C foaming, base substrate after moldings formed therefrom is placed in retort furnace and is slowly warming up to 1000 ~ 1200 DEG C of process 8 ~ 10h, and cooling obtains Nano-grained Hydroxyapatite Ceramics finished product after coming out of the stove.
The present invention relative to the beneficial effect of prior art is:
The Nano-grained Hydroxyapatite Ceramics that the present invention prepares has higher biological activity, and improves its degradation property, and preparation method is simple, and repeatability is high, can large-scale production.
Embodiment
Be described in further details the present invention below by embodiment, these embodiments are only used for the present invention is described, do not limit the scope of the invention.
embodiment 1
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 20 parts, Al
2o
360 parts, CaO 10 parts, ZrO
25 parts, Y
2o
35 parts, CaF
25 parts.
Its preparation method, comprises the following steps:
After said components is prepared burden in proportion, add alcoholic solution and carry out Homogeneous phase mixing, kneading, then evaporating solvent in 80 DEG C of water-baths, to heat in the baking oven of 80 DEG C foaming, base substrate after moldings formed therefrom is placed in retort furnace and is slowly warming up to 1000 DEG C of process 10h, and cooling obtains Nano-grained Hydroxyapatite Ceramics finished product after coming out of the stove.
embodiment 2
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 25 parts, Al
2o
340 parts, CaO20 part, ZrO
210 parts, Y
2o
38 parts, CaF
21 ~ 10 part.
Its preparation method, comprises the following steps:
After said components is prepared burden in proportion, add alcoholic solution and carry out Homogeneous phase mixing, kneading, then evaporating solvent in 80 DEG C of water-baths, to heat in the baking oven of 85 DEG C foaming, base substrate after moldings formed therefrom is placed in retort furnace and is slowly warming up to 1000 DEG C of process 10h, and cooling obtains Nano-grained Hydroxyapatite Ceramics finished product after coming out of the stove.
embodiment 3
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 30 parts, Al
2o
350 parts, CaO 15 parts, ZrO
26 parts, Y
2o
36 parts, CaF
25 parts.
Its preparation method, comprises the following steps:
After said components is prepared burden in proportion, add alcoholic solution and carry out Homogeneous phase mixing, kneading, then evaporating solvent in 80 DEG C of water-baths, to heat in the baking oven of 85 DEG C foaming, base substrate after moldings formed therefrom is placed in retort furnace and is slowly warming up to 1200 DEG C of process 8h, and cooling obtains Nano-grained Hydroxyapatite Ceramics finished product after coming out of the stove.
embodiment 4
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 40 parts, Al
2o
345 parts, CaO 18 parts, ZrO
26 parts, Y
2o
37 parts, CaF
24 parts.
Its preparation method, comprises the following steps:
After said components is prepared burden in proportion, add alcoholic solution and carry out Homogeneous phase mixing, kneading, then evaporating solvent in 80 DEG C of water-baths, to heat in the baking oven of 85 DEG C foaming, base substrate after moldings formed therefrom is placed in retort furnace and is slowly warming up to 1100 DEG C of process 9h, and cooling obtains Nano-grained Hydroxyapatite Ceramics finished product after coming out of the stove.
embodiment 5
A kind of Nano-grained Hydroxyapatite Ceramics, is made up of the component of following weight part:
Hydroxyapatite 50 parts, Al
2o
340 parts, CaO 10 parts, ZrO
28 parts, Y
2o
38 parts, CaF
25 parts.
Its preparation method, comprises the following steps:
After said components is prepared burden in proportion, add alcoholic solution and carry out Homogeneous phase mixing, kneading, then evaporating solvent in 80 DEG C of water-baths, to heat in the baking oven of 90 DEG C foaming, base substrate after moldings formed therefrom is placed in retort furnace and is slowly warming up to 1200 DEG C of process 8h, and cooling obtains Nano-grained Hydroxyapatite Ceramics finished product after coming out of the stove.
Claims (8)
1. a Nano-grained Hydroxyapatite Ceramics, is characterized in that: be made up of the component of following weight part:
Hydroxyapatite 20 ~ 50 parts, Al
2o
340 ~ 60 parts, CaO 10 ~ 20 parts, ZrO
21 ~ 10 part, Y
2o
31 ~ 10 part, CaF
21 ~ 10 part.
2. a Nano-grained Hydroxyapatite Ceramics, is characterized in that: be made up of the component of following weight part:
Hydroxyapatite 25 ~ 30 parts, Al
2o
340 ~ 45 parts, CaO 15 ~ 20 parts, ZrO
22 ~ 3 parts, Y
2o
32 ~ 4 parts, CaF
24 ~ 5 parts.
3. a Nano-grained Hydroxyapatite Ceramics, is characterized in that: be made up of the component of following weight part:
Hydroxyapatite 30 ~ 35 parts, Al
2o
345 ~ 50 parts, CaO 10 ~ 15 parts, ZrO
25 ~ 6 parts, Y
2o
36 ~ 8 parts, CaF
22 ~ 3 parts.
4. a Nano-grained Hydroxyapatite Ceramics, is characterized in that: be made up of the component of following weight part:
Hydroxyapatite 35 ~ 40 parts, Al
2o
350 ~ 55 parts, CaO 15 ~ 18 parts, ZrO
26 ~ 8 parts, Y
2o
38 ~ 9 parts, CaF
22 ~ 3 parts.
5. a Nano-grained Hydroxyapatite Ceramics, is characterized in that: be made up of the component of following weight part:
Hydroxyapatite 40 ~ 45 parts, Al
2o
355 ~ 60 parts, CaO 18 ~ 20 parts, ZrO
28 ~ 10 parts, Y
2o
38 ~ 10 parts, CaF
24 ~ 6 parts.
6. a Nano-grained Hydroxyapatite Ceramics, is characterized in that: be made up of the component of following weight part:
Hydroxyapatite 45 ~ 50 parts, Al
2o
340 ~ 55 parts, CaO 10 ~ 14 parts, ZrO
22 ~ 5 parts, Y
2o
36 ~ 7 parts, CaF
25 ~ 8 parts.
7. a Nano-grained Hydroxyapatite Ceramics, is characterized in that: be made up of the component of following weight part:
Hydroxyapatite 30 ~ 40 parts, Al
2o
340 ~ 50 parts, CaO 10 ~ 15 parts, ZrO
26 ~ 7 parts, Y
2o
37 ~ 8 parts, CaF
23 ~ 5 parts.
8. a preparation method for Nano-grained Hydroxyapatite Ceramics, is characterized in that: comprise the steps:
After said components is prepared burden in proportion, add appropriate alcoholic solution and carry out Homogeneous phase mixing, kneading, then evaporating solvent in 80 DEG C of water-baths, to heat in the baking oven of 70 ~ 90 DEG C foaming, base substrate after moldings formed therefrom is placed in retort furnace and is slowly warming up to 1000 ~ 1200 DEG C of process 8 ~ 10h, and cooling obtains Nano-grained Hydroxyapatite Ceramics finished product after coming out of the stove.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105036747A (en) * | 2015-06-25 | 2015-11-11 | 合肥蓝科新材料有限公司 | Nano-hydroxyapatite-doped high-density motor carbon brush material and preparation method thereof |
| CN106045495A (en) * | 2016-05-25 | 2016-10-26 | 西南科技大学 | Method for preparing porous fluorapatite ceramic adsorbing radioactive nuclide |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0670658A (en) * | 1992-08-25 | 1994-03-15 | Sangi Co Ltd | Pearl nucleus to be used in pearl culture |
| CN1397518A (en) * | 2002-08-28 | 2003-02-19 | 中国科学院长春应用化学研究所 | Process for preparing nano-class hydroxyphosphorite/alumina bioceramics |
| CN1927769A (en) * | 2005-09-06 | 2007-03-14 | 四川大学 | Preparation method and apparatus of nano porous biologic ceramics |
| CN102000361A (en) * | 2010-11-02 | 2011-04-06 | 陕西科技大学 | Preparation method of HA (Hydroxyapatite)-beta-tricalcium phosphate-alumina three-phase composite bioceramic |
| WO2013004361A2 (en) * | 2011-07-06 | 2013-01-10 | Nobel Biocare Services Ag | Composite ceramic for dental implants |
-
2014
- 2014-12-02 CN CN201410713067.XA patent/CN104496459B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0670658A (en) * | 1992-08-25 | 1994-03-15 | Sangi Co Ltd | Pearl nucleus to be used in pearl culture |
| CN1397518A (en) * | 2002-08-28 | 2003-02-19 | 中国科学院长春应用化学研究所 | Process for preparing nano-class hydroxyphosphorite/alumina bioceramics |
| CN1927769A (en) * | 2005-09-06 | 2007-03-14 | 四川大学 | Preparation method and apparatus of nano porous biologic ceramics |
| CN102000361A (en) * | 2010-11-02 | 2011-04-06 | 陕西科技大学 | Preparation method of HA (Hydroxyapatite)-beta-tricalcium phosphate-alumina three-phase composite bioceramic |
| WO2013004361A2 (en) * | 2011-07-06 | 2013-01-10 | Nobel Biocare Services Ag | Composite ceramic for dental implants |
Non-Patent Citations (1)
| Title |
|---|
| 张杭州等: "羟基磷灰石/TiO2纳米管复合生物相容性", 《中国组织工程研究》, no. 3, 31 March 2014 (2014-03-31) * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105036747A (en) * | 2015-06-25 | 2015-11-11 | 合肥蓝科新材料有限公司 | Nano-hydroxyapatite-doped high-density motor carbon brush material and preparation method thereof |
| CN106045495A (en) * | 2016-05-25 | 2016-10-26 | 西南科技大学 | Method for preparing porous fluorapatite ceramic adsorbing radioactive nuclide |
| CN106045495B (en) * | 2016-05-25 | 2018-07-03 | 西南科技大学 | A kind of porous fluor-apatite ceramic preparation of Adsorption of Radioactive nucleic |
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| CN104496459B (en) | 2016-12-07 |
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