CN116687793A

CN116687793A - Use of myristyl nicotinate in cosmetics

Info

Publication number: CN116687793A
Application number: CN202310830123.7A
Authority: CN
Inventors: 蒋丽刚
Original assignee: Hangzhou Ruiyan Prospective Biotechnology Co ltd
Current assignee: Hangzhou Ruiyan Prospective Biotechnology Co ltd
Priority date: 2023-07-07
Filing date: 2023-07-07
Publication date: 2023-09-05

Abstract

The invention relates to an application of myristyl nicotinate in cosmetics, which is characterized in that: can be used as efficacy synergist of specific efficacy active ingredients in cosmetics. The myristyl nicotinate has the effect of promoting other functional components to play roles, and particularly can enhance the anti-wrinkle effect of specific anti-wrinkle actives, enhance the whitening and freckle-removing effect of specific whitening and freckle-removing actives, enhance the acne-removing effect of specific acne-removing actives, enhance the repairing and soothing effects of specific repairing actives and particularly enhance the anti-alopecia effect of anti-alopecia actives.

Description

Use of myristyl nicotinate in cosmetics

Technical Field

The invention relates to the field of cosmetics, in particular to application of myristyl nicotinate in cosmetics.

Background

The requirements of consumers on the efficacy of cosmetics are higher and higher at present, so that the types of the efficacy components in the cosmetics are more and more, the addition amount is higher and higher, but the excessive types of the efficacy components and the too high concentration of the efficacy components can irritate the skin, and skin adverse reactions such as allergy and the like are caused. Therefore, the development of the cosmetic efficacy active substance with the synergistic effect, which is used together with the efficacy components, can reduce the addition amount of the efficacy components in the cosmetics without affecting the efficacy exertion, is very valuable.

Disclosure of Invention

The invention aims to solve the technical problem that the application of myristyl nicotinate as an efficacy active ingredient synergist in cosmetics can be synergistically enhanced with each efficacy active ingredient of the cosmetics.

In order to solve the technical problems, the invention adopts the following technical scheme: use of myristyl nicotinate in cosmetics characterized in that: as an efficacy enhancer for specific efficacy active ingredients in cosmetics.

Further, the cosmetic formulation contains 0.5-5% by mass of myristyl nicotinate to enhance the anti-wrinkle efficacy of the following anti-wrinkle actives at the corner of the eye; the anti-wrinkle active substance is acetyl hexapeptide-8, acetyl hexapeptide-1, blue copper peptide, palmitoyl tripeptide-8, palmitoyl tripeptide-5, acetyl tetrapeptide-2, acetyl tetrapeptide-3, acetyl tetrapeptide-9, acetyl tetrapeptide-11, oligopeptide-1, dipeptide-4, heptapeptide-6, hexapeptide-9, hexapeptide-11, cyclopeptide-5, carnosine, decarboxylated carnosine hydrochloride, ergothioneine, astaxanthin, ideben, ubiquinone, lipoic acid, bakuchiol, hydroxypropyl tetrahydropyran triol, tetrahydropyrimidic acid, mevalonic acid lactone, ethyl bis iminomethyl guaiacol manganese chloride, dimethyl methoxybenzodihydropyranol, tocopherol, tocopheryl nicotinate, retinol, retinaldehyde, retinol, sodium, and sodium acetate tocopheryl retinoic acid, tocopheryl acetate, retinol palmitate, retinol Huang Chunya oleate, retinol propionate, retinol acetate, nicotinamide ethyl retinoic acid, sulforaphane, adenosine phosphate, silymarin, procyanidins, pycnogenol, betulin, betulinic acid, salidroside, zoavid, ribose, diguanosine tetraphosphate, sodium tetrahydrojasmonate, guanosine, uridine, hydroxytyrosol, glutamine, N-acetylcysteine, glycogen, hexose-6-phosphoric acid, trisodium 1, 6-bisphosphate, linseed extract, phytol, pantethine, methyl dihydrojasmonate.

Further, the cosmetic formula contains 0.5-5% of myristyl nicotinate in mass ratio, and is used for improving the whitening and freckle-removing effects of the following whitening and freckle-removing active substances in the whitening and freckle-removing cosmetics; the whitening and freckle-removing active substance is any one of nicotinamide, tranexamic acid, alpha-arbutin, beta-arbutin, 4-methoxysalicylic acid potassium, glutathione, tranexamic acid, phenethyl resorcinol, 4-butyl resorcinol, hexyl resorcinol, tetrahydrocurcumin, resveratrol, oxidized resveratrol, epigallocatechin gallate, ferulic acid, ascorbic acid, ascorbyl tetraisopalmitate, ascorbyl palmitate, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl glucoside, glabridin, azelaic acid, ellagic acid, acetylglucosamine, diglucosyl gallate, 2-mercaptonicotinyl glycine, hydrolyzed conchiolin, d-panthenol, 3-o-ethyl ascorbic acid, bisabolol and thymol trimethoxycinnamate.

Further, the cosmetic formula contains 0.5-5% by mass of myristyl nicotinate for increasing the acne-removing efficacy of the following acne-removing actives in an acne-removing cosmetic; the acne removing active substance is any one of salicylic acid, mandelic acid, lactobionic acid, glucolactone, maltobionic acid, tea tree essential oil, PCA zinc, peach toposide, magnolol, honokiol, colloidal sulfur, paeonol, selenium disulfide, tannic acid, folic acid, matrine, phytic acid and chlorogenic acid.

Further, the cosmetic formulation contains 0.5-5% by mass of myristyl nicotinate for enhancing the repair relief efficacy of the following repair actives in a repair relief cosmetic; the repairing active substance is any one of ceramide NP, ceramide EOP, ceramide AP, ceramide NS, hydroxyphenylpropionyl benzoic acid, centella asiatica extract, kava extract, olive leaf extract, quercetin, isoquercetin, dihydroquercetin, gentiopicroside, tetrandrine, hesperidin, naringin, neohesperidin, synephrine, 4-tert-butylcyclohexanol, guaiacol sodium sulfonate, guaiacol, heparin sodium, baicalin, dipotassium glycyrrhizinate, stearyl glycyrrhetinate, luteolin, apigenin, ruscogenin, cycloastragaloside, fisetin, 6-gingerol and scyllitol.

Further, the cosmetic formula contains 0.5-5% by mass of myristyl nicotinate for increasing the anti-hair loss efficacy of the following anti-hair loss actives in anti-hair loss cosmetics; the active substance for preventing alopecia is any one of swertiamarin, cacumen Platycladi extract, adenosine, pyrrolidinyl diaminopyrimidine oxide, inositol nicotinate, and caffeine.

Myristyl nicotinate, an oil-soluble derivative of niacin, a vitamin B group component, avoids skin irritation from niacin, and has niacin efficacy. Myristyl nicotinate is a fat-soluble substance, and because of its oleophilic nature, myristyl nicotinate increases skin penetration. Myristyl nicotinate can maintain a youthful condition of the skin by activating the nad+ levels of the skin. Myristyl nicotinate enhances the penetration of actives into the skin by activating the energy metabolism level of the skin, thus it has the ability to boost the efficacy of other cosmetically active ingredients.

The invention has the beneficial effects that the myristyl nicotinate and the specific cosmetic efficacy active substance are applied together in the cosmetic formula, the efficacy of the corresponding efficacy active substance can be synergistically enhanced, and the myristyl nicotinate can be promoted to exert stronger product efficacy under the condition of not increasing the dosage of the efficacy active substance.

Detailed Description

The following embodiments better illustrate the present invention, but the present invention is not limited to the following embodiments.

Example 1: myristyl nicotinate can potentiate the anti-wrinkle efficacy of a particular anti-wrinkle active in the corner of the eye.

According to the test method, a test sample containing myristyl nicotinate and anti-wrinkle raw materials is used as an experimental group, a test sample which does not contain myristyl nicotinate and is consistent with the anti-wrinkle raw materials of the experimental group is used as a control group, 30 volunteers are selected, and after the two groups of test samples are respectively used for 1 month at left and right eyes of the same volunteer, the improvement rate of total wrinkles at 30 human eye corner wrinkle positions of the experimental group relative to the control group is used for representing the improvement condition of the anti-wrinkle efficacy. Experiments were performed in human efficacy laboratory, a prospective biotechnology limited company, rui research, hangzhou. The experimental results are shown in tables 1-63.

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Table 63

As can be seen from tables 1-63, the addition of myristyl nicotinate to the cosmetic formulation allows for a different degree of synergy with respect to the anti-wrinkle efficacy of the particular anti-wrinkle active in the claims, which synergistic effect is universal, and the different proportions of myristyl nicotinate and the particular anti-wrinkle active allow for a better anti-wrinkle effect of the anti-wrinkle active.

Example 2: myristyl nicotinate can enhance the whitening and freckle-removing effects of specific whitening and freckle-removing actives in cosmetics.

The second method (a human body opening use freckle removing and whitening efficacy testing method) in the state drug administration No. 17 notice annex 7 cosmetic freckle removing and whitening efficacy testing method is adopted, a test sample containing myristyl nicotinate and freckle removing and whitening raw materials is taken as an experimental group, a test sample which does not contain myristyl nicotinate and is consistent with the freckle removing and whitening raw materials of the experimental group is taken as a control group, 30 effective volunteers are selected, after the two groups of test samples are used for 8 weeks on the face of a subject correctly and continuously, L, a and b values of the skin in the freckle areas of the experimental part and the test part of the control group are respectively measured by a skin colorimeter, improvement values before and after ITA (individual type angle) testing are recorded and calculated, and improvement conditions of the freckle removing and whitening efficacy are represented by the improvement values of the experimental group relative to the ITA of the control group. Experiments were performed in human efficacy laboratory, a prospective biotechnology limited company, rui research, hangzhou. The results of the experiments are shown in tables 64 to 94.

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Table 94

As can be seen from the data in tables 64-94, the addition of myristyl nicotinate to the cosmetic formulation resulted in a more or less universal synergistic effect on the efficacy of the particular anti-freckle and whitening actives of the claims, and the different ratios of myristyl nicotinate to anti-freckle and whitening actives resulted in a better anti-freckle and whitening effect for the particular anti-freckle actives.

Example 3: myristyl nicotinate can enhance the anti-acne efficacy of specific anti-acne actives in cosmetics.

30 healthy male and female volunteers 18-45 years old were selected, with mild (acne only) and moderate (acne with inflammatory papulopustule) acne on the face, with 10-30 papules plus pustules on the whole face. And taking a test sample containing myristyl nicotinate and acne-removing active substances as an experimental group, and taking a test sample which does not contain myristyl nicotinate and is consistent with the acne-removing active substances of the experimental group as a control group, ensuring that the two groups of test samples are correctly and continuously used for 4 weeks on the face target area of a subject, characterizing the acne-removing efficacy according to the total number of the acne reductions of the face target area of the subject before and after the product is used, and characterizing the improvement condition of the acne-removing efficacy by the difference value of the acne reduction of the experimental group and the acne reduction of the control group. Experiments were performed in human efficacy laboratory, a prospective biotechnology limited company, rui research, hangzhou. The results of the experiments are shown in tables 95 to 114.

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As can be seen from the data in tables 95-114, the addition of myristyl nicotinate to the cosmetic formulation resulted in a more or less universal synergy of the specific anti-acne actives of the synergistic claims, and the different ratios of myristyl nicotinate to specific anti-acne actives resulted in a better anti-acne effect of the specific anti-acne actives.

Example 4: myristyl nicotinate can enhance the repair and relief efficacy of specific repair and relief active ingredients in cosmetics.

30 women (sensitive muscles) were selected for positive in the 18-45 year old lactic acid stinging test, excluding women currently in pregnancy or lactation, persons with antihistamines or immunosuppressants in the last 1 week, persons with any anti-inflammatory drugs applied to the test site in the last 2 months, persons with clinical unhealed inflammatory skin diseases, patients with insulin dependent diabetes or asthma or other chronic respiratory diseases undergoing treatment, patients with immunodeficiency or autoimmune diseases, persons on the skin where the test results are affected by scars, pigments, atrophy, port-marks or other blemishes, persons with high physique sensitivity, persons with the last 1 month period taking part in related or other clinical experiments, etc. may affect the activity of the test results. Test samples containing myristyl nicotinate and a repairing and soothing active ingredient are used as experimental groups, test samples which do not contain myristyl nicotinate and are consistent with repairing and soothing ingredients of the experimental groups are used as control groups, the fact that the two groups of test samples are correctly and continuously used for 4 weeks in a face target area of a subject is ensured, the dryness, smoothness and redness of the skin of the subject are scored according to a visual evaluation scoring scale of table 115, and the repairing and soothing effect of the cosmetic is determined by determining the difference before and after the use of the cosmetic through self visual evaluation. The improvement in the relief efficacy of the repair was characterized by the difference in the number of persons who self-described relief improvement (relief improvement rate) in the experimental versus control groups for 30 sensitive muscle volunteers. Experiments were performed in human efficacy laboratory, a prospective biotechnology limited company, rui research, hangzhou. The results of the experiments are shown in tables 116-145.

Table 115: visual assessment scoring scale

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As can be seen from the experimental data in tables 116-146, the addition of myristyl nicotinate to the cosmetic formulation resulted in a more or less universal synergistic effect of the specific soothing ingredients of the synergistic claims, and the different ratios of myristyl nicotinate to specific soothing ingredients resulted in a better soothing effect of the specific soothing active ingredients.

Example 5: myristyl nicotinate can enhance the anti-hair loss efficacy of specific anti-hair loss ingredients in cosmetics.

The test method adopts a test method for preventing hair loss of a cosmetic with annex 8 advertised in the 17 th year of the national drug administration 2021, takes a test sample containing myristyl nicotinate and anti-drop components as an experimental group, takes a test sample which does not contain myristyl nicotinate and is consistent with the anti-drop components of the experimental group as a control group, selects 30 effective volunteers, ensures that the two groups of test samples can not be washed within 48+/-4 hours before the visit of a subject and can not be combed in the morning after the continuous use of the product for 12 weeks, adopts a 60-time hair combing method (the subject can not wash hair and can not be combed in the morning when visiting the subject is in the period of 48+/-4 hours before the visit), adopts a comb with the same specification by the same technician, uniformly combes 60 times (30 times each time from left front to left rear, and 30 times each time) and collects the total quantity of the hair loss of the 30 effective volunteers to represent the anti-drop efficacy, and the improvement degree of the hair loss of the experimental group relative to the control group is used to represent the improvement of the anti-drop efficacy. Experiments were performed in human efficacy laboratory, a prospective biotechnology limited company, rui research, hangzhou. The results of the experiments are shown in tables 147-153.

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As can be seen from the experimental data in tables 147-153, the addition of myristyl nicotinate to the cosmetic formulation resulted in a more or less universal synergistic effect of the specific anti-hair loss ingredients of the synergistic claims, and the different ratios of myristyl nicotinate to specific anti-hair loss ingredients resulted in a better anti-hair loss effect of the specific anti-hair loss ingredients.

The above embodiments are only for illustrating the technical scheme of the present invention, and are not limited thereto.

Claims

1. Use of myristyl nicotinate in cosmetics characterized in that: as an efficacy enhancer for specific efficacy active ingredients in cosmetics.

2. Use of myristyl nicotinate according to claim 1 in cosmetics characterized in that: the cosmetic formula contains 0.5-5% by mass of myristyl nicotinate to enhance the anti-wrinkle effect of the following anti-wrinkle actives at the corner of the eye; the anti-wrinkle active substance is acetyl hexapeptide-8, acetyl hexapeptide-1, blue copper peptide, palmitoyl tripeptide-8, palmitoyl tripeptide-5, acetyl tetrapeptide-2, acetyl tetrapeptide-3, acetyl tetrapeptide-9, acetyl tetrapeptide-11, oligopeptide-1, dipeptide-4, heptapeptide-6, hexapeptide-9, hexapeptide-11, cyclopeptide-5, carnosine, decarboxylated carnosine hydrochloride, ergothioneine, astaxanthin, ideben, ubiquinone, lipoic acid, bakuchiol, hydroxypropyl tetrahydropyran triol, tetrahydropyrimidic acid, mevalonic acid lactone, ethyl bis iminomethyl guaiacol manganese chloride, dimethyl methoxybenzodihydropyranol, tocopherol, tocopheryl nicotinate, retinol, retinaldehyde, retinol, sodium, and sodium acetate tocopheryl retinoic acid, tocopheryl acetate, retinol palmitate, retinol Huang Chunya oleate, retinol propionate, retinol acetate, nicotinamide ethyl retinoic acid, sulforaphane, adenosine phosphate, silymarin, procyanidins, pycnogenol, betulin, betulinic acid, salidroside, zoavid, ribose, diguanosine tetraphosphate, sodium tetrahydrojasmonate, guanosine, uridine, hydroxytyrosol, glutamine, N-acetylcysteine, glycogen, hexose-6-phosphoric acid, trisodium 1, 6-bisphosphate, linseed extract, phytol, pantethine, methyl dihydrojasmonate.

3. Use of myristyl nicotinate according to claim 1 in cosmetics characterized in that: the cosmetic formula contains 0.5-5% of myristyl nicotinate by mass ratio, and is used for increasing the whitening and freckle-removing effects of the following whitening and freckle-removing active substances in the whitening and freckle-removing cosmetics; the whitening and freckle-removing active substance is any one of nicotinamide, tranexamic acid, alpha-arbutin, beta-arbutin, 4-methoxysalicylic acid potassium, glutathione, tranexamic acid, phenethyl resorcinol, 4-butyl resorcinol, hexyl resorcinol, tetrahydrocurcumin, resveratrol, oxidized resveratrol, epigallocatechin gallate, ferulic acid, ascorbic acid, ascorbyl tetraisopalmitate, ascorbyl palmitate, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl glucoside, glabridin, azelaic acid, ellagic acid, acetylglucosamine, diglucosyl gallate, 2-mercaptonicotinyl glycine, hydrolyzed conchiolin, d-panthenol, 3-o-ethyl ascorbic acid, bisabolol and thymol trimethoxycinnamate.

4. Use of myristyl nicotinate according to claim 1 in cosmetics characterized in that: the cosmetic formula contains 0.5-5% of myristyl nicotinate by mass ratio, and is used for improving the acne removing effect of the following acne removing active substances in the acne removing cosmetics; the acne removing active substance is any one of salicylic acid, mandelic acid, lactobionic acid, glucolactone, maltobionic acid, tea tree essential oil, PCA zinc, peach toposide, magnolol, honokiol, colloidal sulfur, paeonol, selenium disulfide, tannic acid, folic acid, matrine, phytic acid and chlorogenic acid.

5. Use of myristyl nicotinate according to claim 1 in cosmetics characterized in that: the cosmetic formula contains 0.5-5% of myristyl nicotinate by mass ratio, and is used for improving the repairing and relieving effects of the following repairing active substances in repairing and relieving cosmetics; the repairing active substance is any one of ceramide NP, ceramide EOP, ceramide AP, ceramide NS, hydroxyphenylpropionyl benzoic acid, centella asiatica extract, kava extract, olive leaf extract, quercetin, isoquercetin, dihydroquercetin, gentiopicroside, tetrandrine, hesperidin, naringin, neohesperidin, synephrine, 4-tert-butylcyclohexanol, guaiacol sodium sulfonate, guaiacol, heparin sodium, baicalin, dipotassium glycyrrhizinate, stearyl glycyrrhetinate, luteolin, apigenin, ruscogenin, cycloastragaloside, fisetin, 6-gingerol and scyllitol.

6. Use of myristyl nicotinate according to claim 1 in cosmetics characterized in that: the cosmetic formula contains 0.5-5% of myristyl nicotinate by mass ratio, and is used for improving the anti-alopecia effect of the following anti-alopecia active matters in the anti-alopecia cosmetic; the active substance for preventing alopecia is any one of swertiamarin, cacumen Platycladi extract, adenosine, pyrrolidinyl diaminopyrimidine oxide, inositol nicotinate, and caffeine.