CN116651724B - Medical intermediate synthesis treatment equipment and synthesis treatment method - Google Patents
Medical intermediate synthesis treatment equipment and synthesis treatment method Download PDFInfo
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- CN116651724B CN116651724B CN202310712966.7A CN202310712966A CN116651724B CN 116651724 B CN116651724 B CN 116651724B CN 202310712966 A CN202310712966 A CN 202310712966A CN 116651724 B CN116651724 B CN 116651724B
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- screening
- plate
- rotating
- pushing
- screening box
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- 238000000034 method Methods 0.000 title claims abstract description 22
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 20
- 238000003786 synthesis reaction Methods 0.000 title claims abstract description 20
- 238000012216 screening Methods 0.000 claims abstract description 150
- 239000002245 particle Substances 0.000 claims abstract description 53
- 238000007664 blowing Methods 0.000 claims abstract description 21
- 238000001035 drying Methods 0.000 claims abstract description 18
- 239000000543 intermediate Substances 0.000 claims description 86
- 238000007599 discharging Methods 0.000 claims description 21
- 238000007789 sealing Methods 0.000 claims description 17
- 239000012450 pharmaceutical intermediate Substances 0.000 claims description 14
- 230000000149 penetrating effect Effects 0.000 claims description 10
- 238000003860 storage Methods 0.000 claims description 10
- 238000005096 rolling process Methods 0.000 claims description 9
- 230000006835 compression Effects 0.000 claims description 6
- 238000007906 compression Methods 0.000 claims description 6
- 239000011324 bead Substances 0.000 claims description 5
- 230000000903 blocking effect Effects 0.000 claims description 3
- 238000001125 extrusion Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 5
- 238000001308 synthesis method Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 49
- 239000008187 granular material Substances 0.000 description 32
- 238000007873 sieving Methods 0.000 description 7
- 238000003672 processing method Methods 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/06—Cone or disc shaped screens
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/46—Constructional details of screens in general; Cleaning or heating of screens
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/46—Constructional details of screens in general; Cleaning or heating of screens
- B07B1/4609—Constructional details of screens in general; Cleaning or heating of screens constructional details of screening surfaces or meshes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B1/00—Sieving, screening, sifting, or sorting solid materials using networks, gratings, grids, or the like
- B07B1/46—Constructional details of screens in general; Cleaning or heating of screens
- B07B1/50—Cleaning
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B21/00—Arrangements or duct systems, e.g. in combination with pallet boxes, for supplying and controlling air or gases for drying solid materials or objects
- F26B21/001—Drying-air generating units, e.g. movable, independent of drying enclosure
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
- B07B—SEPARATING SOLIDS FROM SOLIDS BY SIEVING, SCREENING, SIFTING OR BY USING GAS CURRENTS; SEPARATING BY OTHER DRY METHODS APPLICABLE TO BULK MATERIAL, e.g. LOOSE ARTICLES FIT TO BE HANDLED LIKE BULK MATERIAL
- B07B2201/00—Details applicable to machines for screening using sieves or gratings
- B07B2201/04—Multiple deck screening devices comprising one or more superimposed screens
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Drying Of Solid Materials (AREA)
Abstract
The invention relates to the technical field of medical intermediate processing, in particular to medical intermediate synthesis treatment equipment and a synthesis method. According to the invention, when the medical intermediate is subjected to multistage continuous screening, the hot air blown out from the blowing holes in the drying screen group pushes the medical intermediate particles to rotate, so that the effect of screening the medical intermediate particles is achieved, meanwhile, the medical intermediate particles are dried in a blowing way in the screening process of the medical intermediate particles, meanwhile, the medical intermediate particles are blown to move through wind force, the problem that the medical intermediate particles are broken due to stronger pushing force on the medical intermediate particles when the medical intermediate particles are pushed to move through a rigid structure is avoided, the multifunctional effect is achieved, and the pushing rod is pushed to be inserted into the screening holes through the cooperation of the pushing slide rod and the pushing slide seat in the rotating plate rotating process, so that the medical intermediate particles clamped in the screening holes are pushed out, the screening holes are prevented from being blocked, and the screening efficiency of the medical intermediate is improved.
Description
Technical Field
The invention relates to the technical field of pharmaceutical intermediate processing, in particular to pharmaceutical intermediate synthesis processing equipment and a synthesis processing method.
Background
In the synthesis process of the medical intermediate, the screening treatment is the most important step for controlling the granularity of the medical intermediate, the screening treatment of the medical intermediate is usually carried out in a multistage continuous screening operation, and part of the medical intermediate (such as the medical intermediate of an adsorbent) is easy to be wet and adhered and agglomerated after being contacted with air due to the characteristic reasons of the medical intermediate, so that the medical intermediate is difficult to carry out the screening operation, yi Ka is difficult to fall in the screening holes when passing through the screening holes, the screening holes are blocked, and the screening efficiency of the medical intermediate is reduced.
Disclosure of Invention
In order to solve the problems, the invention adopts the following technical scheme that the medical intermediate synthesis processing equipment comprises: fixing base, screening bucket, bin outlet and open and shut row material group.
The screening bucket comprises three screening boxes that from the top down connected gradually of installing on the fixing base, and screening hole diameter from the top down that three screening box bottom was offered reduces in proper order, and the screening box top that is located the upside is connected with sealed lid, and the guide is fought to the screening box bottom that is located the downside, and three screening box all are the slope with guide and sealed lid and arrange.
The bin outlet is arranged on the side wall of the screening box, and the bin outlet is positioned at the lower side of the screening box in the inclined direction.
The opening and closing discharging group is arranged on the screening box and used for opening the discharging hole to discharge screened medical intermediate particles.
Be equipped with dry screening group in the screening bucket, dry screening group is including sealed lid bottom rotate the connection with screening box concentric and run through the rotation axis of a plurality of screening boxes, the rotation axis is hollow structure, the bottom of rotation axis is connected through the motor that the floor is connected with the direction fill inner wall, rather than the conveyer pipe of intercommunication and run through sealed lid is installed at the top of rotation axis, the outer wall cover of rotation axis is equipped with from the top down and arranges in proper order and rather than the rotor plate that is the cavity structure of intercommunication, the rotor plate is located screening box, a plurality of blowholes rather than the intercommunication are seted up to one side of rotor plate, the blowhole slope is arranged downwards, the one end rotation that the rotor plate kept away from the rotation axis is connected with the rotatory roller at screening box inner wall rolling, the top pushing component that is used for preventing screening hole jam is installed to the lateral wall of rotation axis.
Preferably, the pushing component comprises a fixed ring fixedly sleeved at one end of a rotating shaft, wherein the fixed ring is positioned in the guide hopper, a top sliding seat uniformly distributed along the circumferential direction of the rotating shaft is arranged on each of the fixed ring and the rotating plate, a movable ring which is sequentially distributed from top to bottom and slides up and down is sleeved on the rotating shaft, the movable ring is connected with the bottom of a screening box positioned above the movable ring through a telescopic rod, the movable ring is positioned above the corresponding top sliding seat, a connecting rod uniformly distributed along the circumferential direction of the movable ring is arranged on the outer ring surface of the movable ring, pushing rods are arranged at the top of the connecting rod, the pushing rods are in one-to-one correspondence with the screening holes, the diameters of the pushing rods sequentially reduce from top to bottom, the bottom of the movable ring is provided with a top sliding rod which is circumferentially distributed along the movable ring and in one-to-one correspondence with the top sliding seat, a rotating groove is formed in the inner ring surface of the movable ring, two guide plates which are symmetrically distributed are in sliding connection with each other in the rotating groove, a spring groove which is slidably connected with the guide plates is formed in the side wall of the rotating shaft, and the spring groove is connected with the guide plates through a reset spring.
Preferably, the opening and closing discharging group comprises a storage groove formed in one side of a discharging hole, a closing door plate is connected in a sliding manner in the storage groove, the closing door plate is connected with the storage groove through an extrusion spring, a penetrating groove is formed in the side wall, far away from the discharging hole, of the screening box, an L-shaped rod is connected in a sliding manner in the penetrating groove, the L-shaped rod is connected with the closing door plate through a rope penetrating through the side wall of the screening box, a pushing groove is formed in one side, far away from the rope, of the penetrating groove, a sealing plate is connected on the L-shaped rod in a sliding manner, and the sealing plate is connected with the pushing groove in a sliding manner;
preferably, the L-shaped rods are slidably connected with arc plates positioned on the outer side walls of the screening boxes, one ends of the L-shaped rods, far away from the screening boxes, are provided with connecting plates together, a compression spring sleeved on the L-shaped rods is connected between the connecting plates and the arc plates, one ends, far away from the screening boxes, of the connecting plates are provided with supporting columns, rolling connection balls are arranged on the supporting columns, and the tops of the fixing seats are slidably connected with extrusion plates.
Preferably, the guide cylinder that communicates with the bin outlet is installed to the lateral wall of screening box, and the length from the top down shortens in proper order of three guide cylinder, and the guide housing that communicates with the guide cylinder is installed to the lower extreme that screening box one side was kept away from to the guide cylinder, and the wind gathering tank has been seted up to the lateral wall of guide cylinder, installs the communicating pipe that communicates with the wind gathering tank jointly between a plurality of guide cylinders, and the guide plate that is cavity structure and communicates with the wind gathering tank is all installed to two inside walls that the guide cylinder was arranged along its width direction, and the guide plate slope is fixed at the guide cylinder inner wall, and the guide plate staggered arrangement of both sides, the drying hole that evenly arranges has been seted up to the terminal surface that the guide plate is close to the screening box.
Preferably, the top of the pushing rod is provided with a ball, and the diameter of the ball is smaller than that of the corresponding screening hole above the ball.
Preferably, the end face of the arc-shaped plate, which is close to the side wall of the screening box, is in rolling connection with symmetrically arranged antifriction beads.
Preferably, arc-shaped hook seats are arranged on two sides of one end, far away from the rotating shaft, of the rotating plate.
In addition, the invention also provides a synthesis processing method of the medical intermediate synthesis processing equipment, which specifically comprises the following steps: step one, an external hot air blower sends hot air into a rotating shaft and a rotating plate through a conveying pipe, and the hot air is blown into a screening box from a blowing hole;
when the motor drives the rotating shaft to rotate, hot air carries out blowing drying on the medicine intermediate particles in the screening box through the blowing holes, meanwhile, the medicine intermediate particles are blown to rotate along the rotating shaft, part of small-diameter medicine intermediate particles in the rotating movement process of the medicine intermediate particles drop from the screening holes to the screening box below in sequence, meanwhile, the medicine intermediate particles are blown and dried in the screening process of the medicine intermediate particles, and meanwhile, the medicine intermediate particles are blown to move through wind force; in the process that the rotating shaft drives the rotating plate to rotate, the pushing component performs anti-blocking cleaning on the screening holes, and the medicine intermediate particles clamped in the screening holes are ejected out of the screening holes;
and thirdly, after screening of the medical intermediate particles, opening a discharge port through an opening and closing discharge group, and taking out the screened medical intermediate particles.
The invention has the beneficial effects that: 1. according to the medical intermediate synthesis processing equipment designed by the invention, when the medical intermediate is subjected to multistage continuous screening, the medical intermediate particles are pushed to rotate by hot air blown out from the air blowing holes in the drying screen group, so that the medical intermediate screening effect is achieved, meanwhile, the medical intermediate particles are dried in a blowing way in the screening process, the medical intermediate particles are prevented from being wet in the screening process, adhesion agglomeration is caused between the medical intermediate particles, the medical intermediate particles are difficult to screen, meanwhile, the medical intermediate particles are blown to move by wind force, the problem that the pushing force on the medical intermediate particles is stronger when the medical intermediate particles are pushed to move by a rigid structure, and the medical intermediate particles are broken is solved.
2. When the discharge hole is opened, hot air is blown to dry the medical intermediate particles discharged to the discharge hole through the communicating pipe, the air collecting groove, the guide plate and the drying hole, and meanwhile, the guide plate prolongs the falling path of the medical intermediate particles, so that the medical intermediate particles are sufficiently dried, and the medical intermediate particles are prevented from being wetted when falling and being discharged.
3. The two sides of one end of the rotating plate far away from the rotating shaft are provided with the arc-shaped hook seats, and the arc-shaped hook seats are used for pushing the medicine intermediate particles accumulated between the rotating plate and the screening box to prevent the rotating roller from rolling the medicine intermediate particles.
Drawings
The invention will be further described with reference to the drawings and examples.
Fig. 1 is a schematic view of a main perspective structure of the present invention.
Fig. 2 is a schematic view of a partial perspective view of the pushing assembly of the present invention.
Fig. 3 is a front view of the present invention.
Fig. 4 is a top view of the present invention.
Fig. 5 is a cross-sectional view taken along A-A of fig. 4 in accordance with the present invention.
Fig. 6 is an enlarged view of the invention at B in fig. 5.
Fig. 7 is a partial top down cross-sectional view of the open-close discharge stack and the dryer screen stack of the present invention.
Fig. 8 is an enlarged view of fig. 7 at C in accordance with the present invention.
Fig. 9 is a front cross-sectional view of the guide cylinder, guide cover, communication pipe, and guide plate of the present invention.
Fig. 10 is a plan sectional view of the guide cylinder, the guide cover, the communication pipe, and the guide plate of the present invention.
In the figure: 1. a fixing seat; 2. a screening box; 20. a guide cylinder; 21. a guide cover; 22. a communicating pipe; 23. a guide plate; 3. sealing cover; 4. a guide hopper; 5. a discharge port; 6. opening and closing the discharging group; 60. a storage tank; 61. extruding a spring; 62. closing the door panel; 63. a through groove; 64. an L-shaped rod; 65. a rope; 66. a pushing groove; 67. a sealing plate; 601. an arc-shaped plate; 610. antifriction beads; 602. a connecting band plate; 603. a compression spring; 604. abutting the column; 605. a push plate; 7. grouping by a drying sieve; 70. a rotation shaft; 71. a delivery tube; 72. a rotating plate; 720. an arc-shaped hook seat; 73. a blowing hole; 74. a rotating roller; 75. a pushing assembly; 750. a fixing ring; 751. a top slide; 752. a moving ring; 753. a telescopic rod; 754. a connecting rod; 755. pushing the push rod; 701. ball supporting; 756. a top slide bar; 757. a guide plate; 758. and a return spring.
Detailed Description
Embodiments of the invention are described in detail below with reference to the attached drawings, but the invention can be implemented in a number of different ways, which are defined and covered by the claims.
Referring to fig. 1, 3, 4, 5 and 7, a pharmaceutical intermediate synthesis processing apparatus includes: fixing base 1, screening bucket, bin outlet 5 and row material group 6 opens and shuts.
The screening bucket comprises three screening box 2 that from the top down connects gradually of installing on fixing base 1, and screening hole diameter from the top down that three screening box 2 bottom was seted up reduces in proper order, and screening box 2 top that is located the upside is connected with sealed lid 3, and guide hopper 4 is installed to screening box 2 bottom that is located the downside, and three screening box 2 all are the slope with guide hopper 4 and sealed lid 3 and arrange.
The discharge opening 5 is arranged on the side wall of the screening box 2, and the discharge opening 5 is positioned at the lower side of the screening box 2 in the inclined direction.
The opening and closing discharging group 6 is arranged on the screening box 2 and used for opening the discharging hole 5 to discharge screened medical intermediate particles.
Referring to fig. 1, fig. 4, fig. 5, fig. 6 and fig. 7, a drying sieve group 7 is provided in the sieving barrel, the drying sieve group 7 comprises a rotating shaft 70 which is rotatably connected with the bottom of the sealing cover 3, concentric with the sieving box 2 and penetrates through a plurality of sieving boxes 2, the rotating shaft 70 is of a hollow structure, the bottom of the rotating shaft 70 is connected with the inner wall of the guiding hopper 4 through a motor connected with a rib plate, a conveying pipe 71 which is communicated with the rotating shaft 70 and penetrates through the sealing cover 3 is installed at the top of the rotating shaft 70, a rotating plate 72 which is of a cavity structure and is sequentially arranged from top to bottom and communicated with the rotating shaft 70 is sleeved on the outer wall of the rotating shaft 70, the rotating plate 72 is positioned in the sieving box 2, a plurality of blowing holes 73 which are communicated with the rotating plate 72 are formed in one side of the rotating plate 72, the blowing holes 73 are obliquely arranged downwards, medicine intermediate particles are prevented from adhering to the bottom of the sieving box 2, one end of the rotating plate 72 far from the rotating shaft 70 is rotatably connected with a rotating roller 74 which rolls on the inner wall of the sieving box 2, and a pushing component 75 which is used for preventing the blocking of the sieving holes is installed on the side wall of the rotating shaft 70.
The connecting cylinder that communicates with screening box 2 is installed at the top of sealed lid 3, the connecting cylinder is connected with the outside conveying equipment that carries medicine intermediate granule intermittent type, the conveyer pipe 71 is connected with outside air heater, thereby send into rotation axis 70 and rotor plate 72 with hot-blast, in the hot-blast blowing hole 73 blows screening box 2, when motor drive rotation axis 70 rotates, hot-blast carries out the drying of blowing through blowing hole 73 to medicine intermediate granule in the screening box 2, the medicine intermediate granule is rotatory along rotation axis 70 simultaneously, medicine intermediate granule is at the in-process of rotatory removal partly small diameter medicine intermediate granule drops from screening box 2 of screening hole below in proper order, thereby reach medicine intermediate granule screening's effect, simultaneously carry out the drying of humidity in the in-process of medicine intermediate granule screening, prevent medicine intermediate granule from receiving the humidity influence in the air, lead to producing the adhesion caking between the medicine intermediate granule, be difficult to carry out the screening through the removal of blowing intermediate granule, the driving force that medicine intermediate granule received is harder when having avoided pushing medicine intermediate granule through rigid structure simultaneously, the medicine intermediate granule is comparatively broken.
Referring to fig. 7, arc-shaped hook seats 720 are mounted on both sides of the end of the rotating plate 72 far away from the rotating shaft 70, the arc-shaped hook seats 720 are used for pushing the medicine intermediate particles accumulated between the rotating plate 72 and the screening box 2, preventing the rotating roller 74 from rolling the medicine intermediate particles, and when the L-shaped rod 64 extends into the screening box 2, the arc-shaped hook seats 720 can hook the L-shaped rod 64 and push the L-shaped rod 64 to move.
Referring to fig. 2, 5 and 6, the pushing assembly 75 includes a fixed ring 750 fixedly sleeved at one end of the rotating shaft 70 located in the guide bucket 4, top sliding bases 751 uniformly distributed along the circumferential direction of the rotating shaft 70 are respectively mounted on the fixed ring 750 and the rotating plate 72, a moving ring 752 sequentially distributed from top to bottom and sliding up and down is sleeved on the rotating shaft 70, the moving ring 752 is connected with the bottom of the screening box 2 located above the moving ring 752 through a telescopic rod 753, the moving ring 752 is located above the corresponding top sliding base 751, a connecting rod 754 uniformly distributed along the circumferential direction of the moving ring 752 is mounted on the outer ring surface of the moving ring 752, a top push rod 755 is mounted on the top of the connecting rod 754, the top push rods 755 are in one-to-one correspondence with the screening holes, the diameters of the top push rods 755 sequentially decrease from top to bottom, a rotating groove is formed in the inner ring surface of the moving ring 752, two guide plates 757 symmetrically distributed in the sliding connection with the rotating groove, a spring groove is formed in the side wall of the rotating shaft 70 and is connected with the guide plates 757 in a sliding manner, and the spring groove is connected with the guide plates 757 through reset springs 758.
The rotation axis 70 drives the deflector 757 to rotate along the rotation groove in the process of rotation, and when the rotation plate 72 is in the process of rotation, the lower extreme of top slide seat 751 and the lower extreme of top slide bar 756 contact, the top slide seat 751 continues to rotate, and the lower extreme of top slide bar 756 moves upwards along top slide seat 751, and the top slide bar 756 promotes the shift ring 752 when moving upwards, and the shift ring 752 drives connecting rod 754 and push rod 755 to upwards move and will sieve the medicine intermediate granule that the downthehole jam of screening, prevents medicine intermediate granule and blocks up the screening of screening hole, influences the screening of medicine intermediate granule.
When the top slide bar 756 is disengaged from the top slide 751, the moving ring 752 moves downwardly under its own weight and the spring return force of the return spring 758 while the top push bar 755 moves out of the screening holes.
Referring to fig. 6, the top of the pushing rod 755 is provided with a ball 701, the diameter of the ball 701 is smaller than the diameter of the corresponding screening hole above the ball 701, and the top of the ball 701 is an arc surface, so as to prevent the breaking of the pharmaceutical intermediate particles when the pushing rod 755 pushes out the pharmaceutical intermediate particles in the screening hole.
Referring to fig. 1, 2, 5, 7 and 8, the opening and closing discharging set 6 includes a storage tank 60 provided at one side of the discharging opening 5, a closing door plate 62 is slidably connected in the storage tank 60, the closing door plate 62 is connected with the storage tank 60 through a compression spring 61, a through groove 63 is provided at a side wall of the screening box 2 far from the discharging opening 5, an L-shaped rod 64 is slidably connected in the through groove 63, the L-shaped rod 64 is connected with the closing door plate 62 through a rope 65 penetrating through a side wall of the screening box 2, a pushing groove 66 is provided at a side of the through groove 63 far from the rope 65, a sealing plate 67 is slidably connected on the L-shaped rod 64, and the sealing plate 67 is slidably connected with the pushing groove 66.
The L-shaped rods 64 are slidably connected with arc plates 601 positioned on the outer side walls of the screening boxes 2, one ends of the L-shaped rods 64 far away from the screening boxes 2 are jointly provided with connecting plates 602, compression springs 603 sleeved on the L-shaped rods 64 are connected between the connecting plates 602 and the arc plates 601, one ends of the connecting plates 602 far away from the screening boxes 2 are provided with supporting columns 604, the supporting columns 604 are in rolling connection with balls, and the tops of the fixing seats 1 are slidably connected with pushing plates 605.
After screening of the pharmaceutical intermediate in the screening barrel is completed, the extruding plate 605 is driven to move towards the screening box 2 by an external driving sliding block connected with the extruding plate 605, the extruding plate 605 pushes the supporting column 604 and the L-shaped rod 64 to move towards the screening box 2, the compression spring 603 is contracted, the L-shaped rod 64 moves into the screening box 2, the rotating plate 72 pushes the L-shaped rod 64 to move towards the sealing plate 67 in the rotating process, the L-shaped rod 64 pulls the closing door plate 62 to open by the rope 65, the pharmaceutical intermediate particles roll towards the discharge opening 5 under the action of self gravity until the pharmaceutical intermediate particles are discharged, the sealing plate 67 is pushed to move towards the pushing groove 66 by the L-shaped rod 64 in the moving process, and the sealing plate 67 is used for preventing the pharmaceutical intermediate particles blown by the rotating plate 72 in the moving process from moving out of the penetrating groove 63.
The adoption of the opening and closing discharging group 6 to open the closing door plate 62 can ensure that the rotating plate 72 and the discharging hole 5 are in a vertical state, so that all the medicine intermediate particles can be smoothly discharged from the discharging hole 5, and the medicine intermediate particles are prevented from being accumulated and falling on the rotating plate 72 and are difficult to discharge.
Referring to fig. 8, the end surface of the arc plate 601, which is close to the side wall of the screening box 2, is in rolling connection with symmetrically arranged antifriction beads 610, and the antifriction beads 610 are used for reducing friction between the arc plate 601 and the screening box 2 in the moving process.
Referring to fig. 9 and 10, the side walls of the screening box 2 are provided with guide barrels 20 communicated with the discharge opening 5, the lengths of the three guide barrels 20 are sequentially shortened from top to bottom, the lower end of one side of the guide barrels 20 away from the screening box 2 is provided with a guide cover 21 communicated with the guide barrels 20, the side walls of the guide barrels 20 are provided with air collecting grooves, a communicating pipe 22 communicated with the air collecting grooves is commonly arranged among the guide barrels 20, two inner side walls of the guide barrels 20 distributed along the width direction are provided with guide plates 23 which are in a cavity structure and communicated with the air collecting grooves, the guide plates 23 are obliquely fixed on the inner walls of the guide barrels 20, the guide plates 23 on two sides are staggered, and the end surfaces of the guide plates 23 close to the screening box 2 are provided with drying holes which are uniformly distributed.
The communicating pipe 22 is connected with outside air heater, and when bin outlet 5 was opened, hot-blast through communicating pipe 22 and gather wind groove, guide plate 23, stoving hole to bin outlet 5 exhaust medicine intermediate granule carries out the drying of blowing, and guide plate 23 has prolonged the route that medicine intermediate granule fell simultaneously to can carry out sufficient drying to medicine intermediate granule, prevent that medicine intermediate granule from wetting when whereabouts discharge.
In addition, the invention also provides a synthesis processing method of the medical intermediate synthesis processing equipment, which specifically comprises the following steps: in the first step, the external hot air blower feeds hot air into the rotary shaft 70 and the rotary plate 72 through the duct 71, and the hot air is blown into the screening box 2 through the blowing holes 73.
Step two, when the motor drives rotation axis 70 to rotate, hot-blast through blowing hole 73 carries out the drying of blowing to the medicine intermediate granule in the screening box 2, simultaneously blow medicine intermediate granule along rotation axis 70 rotation, medicine intermediate granule is at the screening box 2 of screening hole decurrent in proper order in the in-process small diameter of rotatory removal medicine intermediate granule drops, thereby reach medicine intermediate granule screening's effect, simultaneously carry out the drying of blowing to it at medicine intermediate granule screening's in-process, prevent medicine intermediate granule receive the humidity influence in the air to become moist at the in-process of screening, lead to producing the adhesion caking between the medicine intermediate granule, be difficult to carry out the screening, simultaneously blow medicine intermediate granule through wind-force and remove, when having avoided promoting medicine intermediate granule removal through rigid structure, the impetus to medicine intermediate granule is harder, lead to the broken problem of medicine intermediate granule.
During the rotation of the rotating shaft 70 driving the rotating plate 72, the pushing component 75 performs anti-blocking cleaning on the screening holes and ejects the medicine intermediate particles clamped in the screening holes out of the screening holes, so that the problem that the screening efficiency of the medicine intermediate particles is reduced due to the blocking of the screening holes by the medicine intermediate particles is avoided;
and thirdly, after screening of the medical intermediate particles, opening the discharge port 5 through the opening and closing discharge group 6, taking out the screened medical intermediate particles, and obliquely arranging the screening box 2, so that the medical intermediate particles are conveniently discharged from the discharge port 5.
Furthermore, it should be understood that although the present disclosure describes embodiments, not every embodiment is provided with a separate embodiment, and that this description is provided for clarity only, and that the disclosure is not limited to the embodiments described in detail below, and that the embodiments described in the examples may be combined as appropriate to form other embodiments that will be apparent to those skilled in the art.
Claims (5)
1. A pharmaceutical intermediate synthesis processing apparatus, comprising: the screening barrel consists of three screening boxes (2) which are arranged on the fixing seat (1) and are sequentially connected from top to bottom, the diameters of screening holes formed in the bottoms of the three screening boxes (2) are sequentially reduced from top to bottom, a sealing cover (3) is connected to the top of the screening box (2) positioned on the upper side, a guide hopper (4) is arranged at the bottom of the screening box (2) positioned on the lower side, and the three screening boxes (2), the guide hopper (4) and the sealing cover (3) are all obliquely arranged;
the discharging hole (5) is formed in the side wall of the screening box (2), and the discharging hole (5) is positioned at the lower side of the screening box (2) in the inclined direction;
the opening and closing discharging group (6) is arranged on the screening box (2) and is used for opening the discharging port (5) to discharge screened medical intermediate particles;
the opening and closing discharging group (6) comprises a storage groove (60) formed in one side of a discharging hole (5), a closing door plate (62) is connected in a sliding manner in the storage groove (60), the closing door plate (62) is connected with the storage groove (60) through an extrusion spring (61), a penetrating groove (63) is formed in the side wall, far away from the discharging hole (5), of the screening box (2), an L-shaped rod (64) is connected in the penetrating groove (63) in a sliding manner, the L-shaped rod (64) is connected with the closing door plate (62) through a rope (65) penetrating through the side wall of the screening box (2), a pushing groove (66) is formed in one side, far away from the rope (65), of the penetrating groove (63), and a sealing plate (67) is connected with the pushing groove (66) in a sliding manner;
an arc plate (601) positioned on the outer side wall of the screening box (2) is connected to the L-shaped rods (64) in a sliding manner, a connecting plate (602) is commonly installed at one end, far away from the screening box (2), of each L-shaped rod (64), a compression spring (603) sleeved on each L-shaped rod (64) is connected between each connecting plate (602) and each arc plate (601), a supporting column (604) is installed at one end, far away from the screening box (2), of each connecting plate (602), balls are connected to the supporting columns (604) in a rolling manner, a pushing plate (605) is connected to the top of the fixing base (1) in a sliding manner, and the supporting columns (604) and the L-shaped rods (64) are pushed to move towards the screening box (2) by the pushing plate (605);
the screening barrel is internally provided with a drying screen group (7), the drying screen group (7) comprises a rotating shaft (70) which is connected with the bottom of a sealing cover (3) in a rotating way and concentric with the screening boxes (2) and penetrates through a plurality of screening boxes (2), the rotating shaft (70) is of a hollow structure, the bottom of the rotating shaft (70) is connected with the inner wall of a guide hopper (4) through a motor connected with a rib plate, the top of the rotating shaft (70) is provided with a conveying pipe (71) which is communicated with the rotating shaft and penetrates through the sealing cover (3), the outer wall of the rotating shaft (70) is sleeved with a rotating plate (72) which is sequentially arranged from top to bottom and is communicated with the rotating plate, the rotating plate (72) is positioned in the screening boxes (2), the rotating plate (72) pushes an L-shaped rod (64) to move towards a sealing plate (67) in the rotating process, one side of the rotating plate (72) is provided with a plurality of air blowing holes (73) which are communicated with the rotating plate, the air blowing holes (73) are obliquely downwards arranged, one end of the rotating plate (72) far away from the rotating shaft (70) is rotationally connected with a rotating roller (74) which rolls on the inner wall of the screening boxes (2), and the side wall of the rotating plate (70) is provided with a cavity-shaped rotating plate (72), and a rotating plate (72) which is provided with a cavity structure, and a rotating plate (75) which is used for preventing the screening holes from blocking;
the pushing component (75) comprises a rotating shaft (70), a fixing ring (750) is fixedly sleeved at one end of the rotating shaft (70) in the guide hopper (4), pushing rods (755) are respectively arranged at the top of the connecting rods (754) and the rotating plate (72), the pushing rods (755) are respectively and uniformly distributed along the circumference of the rotating shaft (70), moving rings (752) which are sequentially distributed from top to bottom and slide up and down are sleeved on the rotating shaft (70), the moving rings (752) are connected with the bottoms of screening boxes (2) above the moving rings through telescopic rods (753), the moving rings (752) are located above the corresponding pushing rods (751), connecting rods (754) which are uniformly distributed along the circumference of the moving rings (752), pushing rods (755) are respectively arranged at the tops of the connecting rods (754), the pushing rods (755) are respectively and correspond to the screening holes one by one, the diameters of the pushing rods (755) are sequentially reduced downwards, rotating grooves are respectively arranged at the bottoms of the moving rings (752) and correspond to the pushing rods (751) one by one, rotating grooves are formed in the inner ring faces of the moving rings (752), and the bottoms of the corresponding pushing rings (752) through telescopic rods (753), the rotating grooves are respectively, and the two guide plates (757) are symmetrically distributed along the circumference of the rotating rings, and are connected with the sliding plates (7575), and the sliding plates (757) respectively.
2. A pharmaceutical intermediate synthesis processing apparatus according to claim 1, wherein: guide cylinder (20) with bin outlet (5) intercommunication are installed to the lateral wall of screening box (2), the length from the top down shortens in proper order of three guide cylinder (20), guide cover (21) with guide cylinder (20) intercommunication are installed to the lower extreme that screening box (2) one side was kept away from to guide cylinder (20), wind gathering tank has been seted up to the lateral wall of guide cylinder (20), install communicating pipe (22) with wind gathering tank intercommunication jointly between a plurality of guide cylinders (20), guide cylinder (20) are all installed along two inside walls that their width direction was arranged and are cavity structure and with wind gathering tank intercommunication guide plate (23), guide plate (23) slope is fixed at guide cylinder (20) inner wall, guide plate (23) of both sides are crisscross to be arranged, evenly arranged drying hole has been seted up near the terminal surface of screening box (2).
3. A pharmaceutical intermediate synthesis processing apparatus according to claim 1, wherein: and the top of the push rod (755) is provided with a ball abutting (701), and the diameter of the ball abutting (701) is smaller than that of a corresponding screening hole above the ball abutting (701).
4. A pharmaceutical intermediate synthesis processing apparatus according to claim 1, wherein: the end face of the arc plate (601) close to the side wall of the screening box (2) is in rolling connection with symmetrically arranged antifriction beads (610).
5. A pharmaceutical intermediate synthesis processing apparatus according to claim 1, wherein: arc-shaped hook seats (720) are arranged on two sides of one end, far away from the rotating shaft (70), of the rotating plate (72).
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310712966.7A CN116651724B (en) | 2023-06-15 | 2023-06-15 | Medical intermediate synthesis treatment equipment and synthesis treatment method |
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| CN202310712966.7A CN116651724B (en) | 2023-06-15 | 2023-06-15 | Medical intermediate synthesis treatment equipment and synthesis treatment method |
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| CN116651724B true CN116651724B (en) | 2023-11-03 |
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| CN116651724A (en) | 2023-08-29 |
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