CN116649886B - Photographing system convenient for photographing fundus of mouse - Google Patents
Photographing system convenient for photographing fundus of mouse Download PDFInfo
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- CN116649886B CN116649886B CN202310759227.3A CN202310759227A CN116649886B CN 116649886 B CN116649886 B CN 116649886B CN 202310759227 A CN202310759227 A CN 202310759227A CN 116649886 B CN116649886 B CN 116649886B
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- 241000699666 Mus <mouse, genus> Species 0.000 claims abstract description 85
- 241000699670 Mus sp. Species 0.000 claims abstract description 24
- 210000001508 eye Anatomy 0.000 claims abstract description 11
- 210000004247 hand Anatomy 0.000 claims description 14
- 210000003813 thumb Anatomy 0.000 claims description 14
- 210000003811 finger Anatomy 0.000 claims description 11
- 210000005224 forefinger Anatomy 0.000 claims description 8
- 210000003128 head Anatomy 0.000 claims description 8
- 239000007779 soft material Substances 0.000 claims description 3
- 238000010146 3D printing Methods 0.000 claims description 2
- 240000001307 Myosotis scorpioides Species 0.000 claims 1
- 206010002091 Anaesthesia Diseases 0.000 description 5
- 230000037005 anaesthesia Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 230000006978 adaptation Effects 0.000 description 4
- 210000005252 bulbus oculi Anatomy 0.000 description 4
- 210000004087 cornea Anatomy 0.000 description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 208000002177 Cataract Diseases 0.000 description 3
- 241000282414 Homo sapiens Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000001525 retina Anatomy 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 2
- 210000005069 ears Anatomy 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 206010061788 Corneal infection Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0083—Apparatus for testing the eyes; Instruments for examining the eyes provided with means for patient positioning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D3/00—Appliances for supporting or fettering animals for operative purposes
- A61D2003/003—Appliances for supporting or fettering animals for operative purposes with head or neck restraining means
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02D—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN INFORMATION AND COMMUNICATION TECHNOLOGIES [ICT], I.E. INFORMATION AND COMMUNICATION TECHNOLOGIES AIMING AT THE REDUCTION OF THEIR OWN ENERGY USE
- Y02D10/00—Energy efficient computing, e.g. low power processors, power management or thermal management
Abstract
The invention relates to a photographing system for conveniently photographing the fundus of a mouse, which comprises: a photographing device for photographing an image of a fundus of a mouse; the support frame is used for fixing the photographing device and can adjust the photographing device to a proper position; a light condensing device for condensing the light of the photographing device to eyes of the mice; the front mirror is used for being matched with the photographing device to obtain a clear image; the mouse fixing device is used for fixing the mouse so that the mouse is in a stable state capable of being shot; the photographing device is arranged in the supporting frame, the light condensing device is arranged at the lens end of the photographing structure, the light condensing device is detachably connected with the photographing structure, the front mirror is arranged on the light condensing device and is movably connected with the light condensing device, the mouse fixing device is arranged at a position opposite to the lens of the photographing device, and the distance between the mouse fixing device and the photographing device is adjustable; the above-mentioned setting can be completed by one person.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a photographing system for conveniently photographing the fundus of a mouse.
Background
The clinical problems faced at present are: fundus photography in mice is an indispensable means of scientific research that can evaluate nerves and blood vessels on the posterior segment of the eye, including vitreous, optic disc, retina. Fundus photography is a non-invasive imaging method that allows dynamic observation of disease changes. As the most commonly used animal model of ophthalmic diseases, the mouse greatly contributes to the research of pathogenesis of a plurality of fundus diseases and the improvement of a treatment method, and the genotype and the eye structure of the mouse are similar to those of human beings, so that the eye fundus photographing technology of the mouse is important to the development of scientific research; the eyeballs of the mice are smaller than the eyeballs of human beings, and the diameters of the eyeballs are about 3mm, so that eyeground photographing equipment used by the clinical human beings cannot directly meet eyeground photographing of the mice. Common mouse fundus photographing equipment such as Micron IV is expensive and inconvenient to carry at home and abroad. In actual operation, the mice can not be matched independently, fundus photography is needed after anesthesia, eyes are positioned on two sides of the head, an inspector needs to place the inspector at a proper position, and clear and satisfactory images can be shot after accurate alignment.
There have been some prior studies on techniques for taking photographs of the fundus of mice, such as using high refractive power condenser lenses in combination with a biological microscope or camera, and such as applanation of the cornea with a cover slip. But using contact imaging increases the chance of corneal infection; clinical practice often uses a combination of cell phones, slit lamps and pre-mirrors to take pictures of the fundus of the patient, which is a valuable observation for small and medium hospitals or research institutions that do not have sufficient expense and resources.
At present, a mobile phone is combined with a front-end mirror to shoot fundus photography of a mouse, so that clear images comparable to those of micro IV equipment can be obtained; the existing product comprises the following components: the method comprises the steps of fixing two forefeet of a mouse by using an adhesive tape, mounting the mobile phone on a tripod, focusing light rays on the front surface of retina by using the right hand-held foremirror, and collecting images by using a Bluetooth remote controller by using the left hand when the front surface of retina is regulated to be clear images on the mobile phone; because the anatomical position of the eyeballs of the mice and the influence on the shooting angle after anesthesia cannot be mastered in a short period, two persons are often required to cooperate in actual operation, the front mirror is required to be held by an experimenter, labor is very consumed, and shake is easy to occur during shooting; the excessive anesthesia time also leads to increased mortality of mice, increased risk of cornea dryness and cataract occurrence, and serious influence on subsequent experiments.
The invention aims at the problems and provides a photographing system which is convenient for photographing the eyeground of a mouse.
Disclosure of Invention
In order to overcome the problems in the background art, the invention adopts the following technical scheme:
a photographing system for facilitating photographing of a fundus of a mouse, comprising:
a photographing device for photographing an image of a fundus of a mouse;
the support frame is used for fixing the photographing device and can adjust the photographing device to a proper position;
a light condensing device for condensing light of the photographing device to eyes of the mice and amplifying a photographing picture of the photographing device;
the front mirror is used for being matched with the photographing device to obtain a clear image;
the mouse fixing device is used for fixing the mouse so that the mouse is in a stable state capable of being shot;
the photographing device is arranged in the supporting frame, the light condensing device is arranged at the lens end of the photographing structure, the light condensing device is detachably connected with the photographing structure, the front mirror is arranged on the light condensing device and is movably connected with the light condensing device, the mouse fixing device is arranged at a position opposite to the lens of the photographing device, and the distance between the mouse fixing device and the photographing device is adjustable; the operation of one person can be completed, so that the experimental progress is accelerated, and the problems that the anesthesia time is too long, the death rate of mice is increased, the risks of cornea dryness and cataract are increased, and the follow-up experiment is influenced are solved.
Further, a bottom plate is arranged at the bottoms of the supporting frame and the mouse fixing device.
Further, at least one T-shaped guide rail is arranged at the first end of the bottom plate; alternatively two T-shaped rails are provided.
Further, the second end of the bottom plate is symmetrically provided with two first fixing plates, a first connecting rod is arranged in the middle of each first fixing plate, and the support frame can move along the first connecting rod so as to adjust the position of the photographing structure.
Further, the support frame comprises a moving block, a first telescopic structure and a placing structure; the moving block is fixedly connected with the telescopic structure, and the telescopic structure is movably connected with the placement structure; the arrangement ensures that the position and the angle of the placement structure are adjustable.
Further, the movable block is cuboid in shape, a first through hole is formed in the center of the movable block, the first through hole is matched with the connecting rod, the movable block is arranged on the connecting rod, friction force exists between the connecting rod and the first through hole, and position change cannot occur under non-manual operation.
Further, first extending structure includes first telescopic link and second telescopic link, the first end of first telescopic link is fixed on the movable block, first telescopic link and second telescopic link homoenergetic are flexible, the first end fixed connection of the second end of first telescopic link and second telescopic link, the second end of first telescopic link is the same with the first end diameter of second telescopic link, and first telescopic link and second telescopic link junction are smooth connection, and the contained angle is 60-120 degrees between first telescopic link and the second telescopic link, preferably, the contained angle is 90 degrees between first telescopic link and the second telescopic link.
Further, the second end of second telescopic link sets up first circular slot, set up first circular piece in the first circular slot, first circular slot and first circular piece swing joint, there is frictional force between first circular slot and the first circular piece.
Further, a first connecting rod is arranged on the first round block and is fixedly connected with the placement structure.
Further, the inside recess that sets up to be with taking a picture the device adaptation of placing structure, take a picture the lower half of device and can place in placing structure.
Further, the light condensing device comprises a light condensing tube and a fixed shell; the light collecting pipe is fixedly connected with the fixed shell; the camera hole and the flash lamp hole are arranged in the light collecting tube and are communicated with the fixing shell, the fixing shell is matched with the upper part of the photographing device, the fixing shell is separated from the photographing structure and is fixed on the photographing structure, and the camera hole and the flash lamp hole in the light collecting tube are matched with the camera and the flash lamp of the photographing device.
Further, the convex lens is arranged in the camera hole, and the shooting picture can be enlarged through the arrangement.
Further, a movable ring is arranged on the light collecting pipe and is movably connected with the light collecting pipe; the first end of the movable ring is a taper section which is changed from small to large, at least one strip-shaped opening is formed along the direction in which the taper section is changed to large, threads are formed in the outer side of the taper section, a locking ring is arranged in the outer side of the taper section, threads matched with the threads in the outer side of the taper section are formed in the inner side of the locking ring, the locking ring is rotated, and the movable ring can be fixed or loosened.
Further, the second end of the movable ring is provided with at least two arc-shaped rods, the front mirror is arranged on the inner side of the tail end of each arc-shaped rod, and the front mirror is fixedly connected with each arc-shaped rod; the arrangement ensures that the 90 front mirror is not needed to be held by a medical staff any more, and the relative position of the front mirror and the photographing device is adjustable.
Further, the mouse fixing device is set into two simulated hands, the two simulated hands are formed by 3D printing, the shape is the gesture of grabbing a mouse, and the mouse fixing device specifically comprises: the forefinger and the thumb of the first hand are in cross contact to support the head, the other three fingers support the body, the forefinger and the thumb of the second hand are placed behind the ears of the mice, the posture of the forefinger and the thumb is the same as that of the first hand, and the other three fingers are used for simply fixing the body of the mice; the index finger and the thumb of the two simulated hands are soft materials, the distance and the angle of the index finger and the thumb can be adjusted, the two simulated hands can be suitable for mice with different body sizes, and the two simulated hands are fixed on the bottom plate.
Alternatively, the mouse fixing device comprises a placing plate, an upper supporting part and a fixing part; the upper supporting part and the fixing part are respectively fixed on the upper surface of the placing plate.
Further, at least one T-shaped groove is formed in the bottom surface of the placement plate, the T-shaped groove is matched with the T-shaped guide rail, and the placement plate can move along the T-shaped guide rail; the above arrangement ensures that the position of the placing plate is adjustable, and is more convenient in use.
Further, the upper center of the placing plate is provided with a soft cushion, the center of the soft cushion is provided with a smooth protruding block, the abdomen of a mouse can be supported, the mouse can be placed on the protruding block, the comfort of the mouse is guaranteed, and the mouse cannot be disturbed during experiments.
Further, place board first end symmetry and set up two second fixed plates, set up the second connecting rod in the middle of the second fixed plate, the portion of holding in the palm can remove along the second connecting rod.
Further, the upper supporting portion comprises a cylindrical block and an upper supporting block, the cylindrical block and the upper supporting block are respectively arranged in two, and the upper supporting block is arranged on the upper portion of the cylindrical block and is movably connected with the cylindrical block.
Further, the side of the cylindrical block is provided with a second through hole, the second through hole is matched with the second connecting rod, and friction force exists at the joint.
Further, the upper supporting block is cylindrical, a transverse rod is arranged on any side face of the upper supporting block, and an inclined section is arranged on the transverse rod, so that the chin part of a mouse can be conveniently towed.
Further, a first round block is arranged on the upper portion of the cylindrical block, a second round block is arranged on the upper portion of the first round block, the diameter of the second round block is larger than that of the first round block, and a first groove and a second groove are formed in the bottom of the upper supporting block and are respectively matched with the first round block and the second round block; the above-mentioned setting has guaranteed that the upper bracket piece can rotate along the cylinder piece, and the mouse homoenergetic adaptation that transverse rod and size are different has been guaranteed to above-mentioned setting.
Further, the fixing part comprises a second telescopic structure and a pressing block; the second telescopic structure is movably connected with the pressing block; the second telescopic structure and the pressing block are provided with two groups, the two groups of images are arranged on two sides of the upper portion of the placing plate, and the second telescopic structure is fixedly connected to the placing plate.
Further, the second telescopic structure comprises a third telescopic rod and a fourth telescopic rod, the first end of the third telescopic rod is fixed on the moving block, the third telescopic rod and the fourth telescopic rod can stretch out and draw back, the second end of the third telescopic rod is fixedly connected with the first end of the fourth telescopic rod, the diameters of the second end of the third telescopic rod and the first end of the fourth telescopic rod are the same, and the joint of the third telescopic rod and the fourth telescopic rod is in smooth connection.
Further, the second end of fourth telescopic link sets up the second circular slot, set up the circular piece of second in the second circular slot, second circular slot and the circular piece swing joint of second, there is frictional force between second circular slot and the circular piece of second.
Further, a second connecting rod is arranged on the second round block and is fixedly connected with the pressing block; the pressing block is a rectangular block, and a round angle is arranged at the lower part of the pressing block; the arrangement ensures that the pressing block can be pressed on the rear side of the neck of the mouse, so that the head of the mouse is in a stable state, and photographing is facilitated.
Further, the second end of placing the board sets up the control lid, the control lid rotates with placing the board and is connected, and control lid front end and lower extreme are cavity, can detain on the mouse health, prevent that the mouse from moving in disorder or escaping.
The invention has the beneficial effects that: the invention has reasonable structure; the condensing device and the front mirror are connected with the photographing device, so that the operation is convenient, an experimenter is not required to hold the front mirror, the operation can be performed by a single person, and the labor force is saved; by arranging the mouse fixing device, the upper side and the lower side of the head of the mouse can be clamped, so that the head of the mouse is fixed, and the eyes of the mouse can be photographed conveniently; through setting up front mirror and condensing equipment's distance adjustable, can adjust out clear field of vision when having guaranteed to take a picture and be in fixed state after the adjustment is accomplished, the easy problem of shake when having solved handheld.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic diagram of the structure of the support frame, the light condensing device and the front mirror of the present invention;
FIG. 3 is a schematic view of the structure of the light condensing device and the front mirror of the present invention;
FIG. 4 is a schematic view of the structure of the front mirror of the present invention;
FIG. 5 is a schematic view of a condensing device according to the present invention;
FIG. 6 is a schematic view of the structure of the placement plate of the present invention;
FIG. 7 is a schematic view of the structure of the upper bracket of the present invention;
FIG. 8 is a schematic view of the structure of a cylindrical block according to the present invention;
FIG. 9 is a schematic cross-sectional view of the upper support block of the present invention;
FIG. 10 is a schematic view of the structure of the fixing part of the present invention;
FIG. 11 is a schematic view of the structure of the control cap of the present invention;
in the figure, 1, a bottom plate; 2. a T-shaped guide rail; 3. a first fixing plate; 4. a first connecting rod; 5. a moving block; 6. placing a structure; 7. a first telescopic rod; 8. a second telescopic rod; 9. a first circular block; 10. a first link; 11. a light collecting tube; 12. a fixed case; 13. a movable ring; 14. a locking ring; 15. an arc-shaped rod; 16. a front mirror; 17. placing a plate; 18. a soft cushion; 19. a protruding block; 20. a second fixing plate; 21. a second connecting rod; 22. a cylindrical block; 23. a supporting block is arranged; 24. pressing the blocks; 25. a third telescopic rod; 26. a fourth telescopic rod; 27. a second circular block; 28. a second link; 29. a control cover; 30. t-shaped groove.
Detailed Description
The following detailed description of the embodiments of the present invention will be made more apparent to those skilled in the art from the following detailed description, in which the invention is embodied in several, but not all, embodiments of the invention. The invention may be embodied or applied in other specific forms and features of the following examples and examples may be combined with each other without conflict, all other examples being contemplated by those of ordinary skill in the art without undue burden from the present disclosure, based on the examples of the invention.
Example 1
Referring to fig. 1-11, a photographing system for photographing fundus of a mouse in the present embodiment includes:
a photographing device for photographing an image of a fundus of a mouse; the support frame is used for fixing the photographing device and can adjust the photographing device to a proper position; a light condensing device for condensing light of the photographing device to eyes of the mice and amplifying a photographing picture of the photographing device; a front mirror 16 for cooperating with the photographing device to obtain a clear image; the mouse fixing device is used for fixing the mouse so that the mouse is in a stable state capable of being shot; the photographing device is arranged in the supporting frame, the light condensing device is arranged at the lens end of the photographing structure, the light condensing device is detachably connected with the photographing structure, the front mirror 16 is arranged on the light condensing device and is movably connected with the light condensing device, the mouse fixing device is arranged at a position opposite to the lens of the photographing device, and the distance between the mouse fixing device and the photographing device can be adjusted; the operation of one person can be completed, so that the experimental progress is accelerated, and the problems that the anesthesia time is too long, the death rate of mice is increased, the risks of cornea dryness and cataract are increased, and the follow-up experiment is influenced are solved.
The system is not only aimed at mice, but also can be used for measuring the eyeground of other animals.
Example 2
Referring to fig. 1-2, on the basis of embodiment 1, the following technical features are added in this embodiment: (the following specific settings are made for the structure of the support frame): the bottom of the supporting frame and the mouse fixing device is provided with a bottom plate 1.
At least one T-shaped guide rail 2 is arranged at the first end of the bottom plate 1; optionally two T-shaped rails 2 are provided.
Two first fixed plates 3 are symmetrically arranged at the second end of the bottom plate 1, a first connecting rod 4 is arranged in the middle of the first fixed plate 3, and the support frame can move along the first connecting rod 4 so as to adjust the position of the photographing structure.
The support frame comprises a moving block 5, a first telescopic structure and a placing structure 6; the moving block 5 is fixedly connected with a telescopic structure, and the telescopic structure is movably connected with the placing structure 6; the above arrangement ensures that the position and angle of the placement structure 6 are adjustable.
The movable block 5 is in a cuboid shape, a first through hole is formed in the center of the movable block 5 and matched with the connecting rod, the movable block 5 is arranged on the connecting rod, friction force exists between the connecting rod and the first through hole, and position change cannot occur under non-manual operation.
The first telescopic structure comprises a first telescopic rod 7 and a second telescopic rod 8, wherein the first end of the first telescopic rod 7 is fixed on the moving block 5, the first telescopic rod 7 and the second telescopic rod 8 can be telescopic, the second end of the first telescopic rod 7 and the first end of the second telescopic rod 8 are fixedly connected, the diameter of the first end of the first telescopic rod 7 is the same as that of the first end of the second telescopic rod 8, the joint of the first telescopic rod 7 and the second telescopic rod 8 is in smooth connection, the included angle between the first telescopic rod 7 and the second telescopic rod 8 is 60-120 degrees, and preferably, the included angle between the first telescopic rod 7 and the second telescopic rod 8 is 90 degrees.
The second end of the second telescopic rod 8 is provided with a first circular groove, a first circular block 9 is arranged in the first circular groove, the first circular groove is movably connected with the first circular block 9, and friction force exists between the first circular groove and the first circular block 9.
The first round block 9 is provided with a first connecting rod 10, and the first connecting rod 10 is fixedly connected with the placement structure 6.
The inside recess that sets up to with the camera device adaptation of placing structure 6, camera device's latter half can be placed in placing structure 6.
Example 3
Referring to fig. 1-5, on the basis of embodiments 1-2, the following technical features (the following specific arrangements are performed for the structures of the condensing device and the front mirror 16) are added: the light condensing device comprises a light condensing tube 11 and a fixed shell 12; the light collecting pipe 11 is fixedly connected with the fixed shell 12; the camera hole and the flash lamp hole are arranged in the light collecting tube 11, the camera hole and the flash lamp hole are communicated with the fixed shell 12, the fixed shell 12 is matched with the upper part of the photographing device, the fixed shell 12 is separated from the photographing structure and fixed on the photographing structure, and the camera hole and the flash lamp hole in the light collecting tube 11 are matched with the camera and the flash lamp of the photographing device; the photographing device is a mobile phone.
Preferably, the front mirror 16 is a 90D front mirror 16; other models may also be used.
Or the light source is arranged in the flash lamp hole, so that the eye region of the mouse can be illuminated, and the photographing is clearer.
Or, the convex lens is arranged in the camera hole, and the shooting picture can be enlarged through the arrangement.
The movable ring 13 is arranged on the light collecting pipe 11, and the movable ring 13 is movably connected with the light collecting pipe 11; the first end of the movable ring 13 is a taper section from small to large, at least one strip-shaped opening is arranged along the direction of the taper section to large, threads are arranged on the outer side of the taper section, a locking ring 14 is arranged on the outer side of the taper section, threads matched with the threads on the outer side of the taper section are arranged on the inner side of the locking ring 14, the locking ring 14 is rotated, and the movable ring 13 can be fixed or loosened.
The second end of the movable ring 13 is provided with at least two arc-shaped rods 15, the front mirror 16 is arranged on the inner side of the tail end of the arc-shaped rods 15, and the front mirror 16 is fixedly connected with the arc-shaped rods 15; the above arrangement ensures that the 90-degree front mirror 16 is no longer required to be held by a medical staff, and the relative positions of the front mirror 16 and the photographing device are adjustable.
Example 4
Referring to fig. 1,6-11, on the basis of embodiments 1-3, the following technical features (the following specific arrangement is performed on the structure of the mouse fixing device) are added: the mouse fixing device is set into two simulated hands, the two simulated hands are 3D printed, the shape is the gesture of grabbing the mouse, and the mouse fixing device specifically comprises: the forefinger and the thumb of the first hand are crossed to support the head, the other three fingers support the body, the forefinger and the thumb of the second hand are placed behind the ears of the mice, the other three fingers are used for simply fixing the body of the mice, and a fifth telescopic rod is arranged at the lower part of the second hand; the index finger and the thumb of the two simulated hands are made of soft materials, so that the distance and the angle between the index finger and the thumb can be adjusted, and the two simulated hands can be suitable for mice with different body sizes.
Alternatively, the mouse fixing means includes a placement plate 17, an upper supporting portion, and a fixing portion; the upper bracket and the fixing portion are respectively fixed to the upper surface of the placement plate 17.
The bottom surface of the placement plate 17 is provided with at least one T-shaped groove 30, the T-shaped groove 30 is matched with the T-shaped guide rail 2, and the placement plate 17 can move along the T-shaped guide rail 2; the above arrangement ensures that the position of the placement plate 17 is adjustable, and is more convenient in use.
The T-shaped guide rail 2 is perpendicular to the shooting direction of the shooting device, and after the mice are fixed, the shooting structure can shoot eyes of the mice.
The upper center of the placing plate 17 is provided with a soft cushion 18, the center of the soft cushion 18 is provided with a smooth protruding block 19, the abdomen of a mouse can be supported, the mouse can be placed on the protruding block 19, the comfort of the mouse is ensured, and the mouse cannot be disturbed during experiments.
The first end of the placing plate 17 is symmetrically provided with two second fixing plates 20, a second connecting rod 21 is arranged in the middle of the second fixing plates 20, and the upper supporting part can move along the second connecting rod 21.
The upper supporting part comprises a cylindrical block 22 and an upper supporting block 23, the cylindrical block 22 and the upper supporting block 23 are respectively arranged in two, and the upper supporting block 23 is arranged on the upper part of the cylindrical block 22 and is movably connected with the cylindrical block 22.
The side of the cylindrical block 22 is provided with a second through hole which is matched with the second connecting rod 21, and friction exists at the joint.
The upper supporting block 23 is cylindrical, a transverse rod is arranged on any side face of the upper supporting block 23, and an inclined section is arranged on the transverse rod, so that the chin part of a mouse can be conveniently towed.
The upper part of the cylindrical block 22 is provided with a first round block, the upper part of the first round block is provided with a second round block, the diameter of the second round block is larger than that of the first round block, and the bottom of the upper supporting block 23 is provided with a first groove and a second groove which are respectively matched with the first round block and the second round block; the above arrangement ensures that the upper support block 23 can rotate along the cylindrical block 22, and ensures that the transverse rod can be adapted to mice of different sizes.
The fixed part comprises a second telescopic structure and a pressing block 24; the second telescopic structure is movably connected with the pressing block 24; the second telescopic structure and the pressing block 24 are arranged in two groups, two groups of images are arranged on two sides of the upper portion of the placing plate 17, and the second telescopic structure is fixedly connected to the placing plate 17.
The second telescopic structure comprises a third telescopic rod 25 and a fourth telescopic rod 26, the first end of the third telescopic rod 25 is fixed on the moving block 5, the third telescopic rod 25 and the fourth telescopic rod 26 can stretch out and draw back, the second end of the third telescopic rod 25 is fixedly connected with the first end of the fourth telescopic rod 26, the diameters of the second end of the third telescopic rod 25 and the first end of the fourth telescopic rod 26 are the same, and the joint of the third telescopic rod 25 and the fourth telescopic rod 26 is in smooth connection.
The second end of the fourth telescopic rod 26 is provided with a second circular groove, a second circular block 27 is arranged in the second circular groove, the second circular groove is movably connected with the second circular block 27, and friction force exists between the second circular groove and the second circular block 27.
A second connecting rod 28 is arranged on the second round block 27, and the second connecting rod 28 is fixedly connected with the pressing block 24; the pressing block 24 is arranged as a rectangular block, and the lower part of the pressing block 24 is provided with a round angle; the above arrangement ensures that the pressing block 24 can be pressed against the rear side of the neck of the mouse, so that the head of the mouse is in a stable state, and photographing is facilitated.
The second end of the placing plate 17 is provided with a control cover 29, the control cover 29 is rotationally connected with the placing plate 17, the front end and the lower end of the control cover 29 are hollow, and the control cover can be buckled on the body of a mouse to prevent the mouse from moving or escaping.
Example 5
On the basis of embodiment 2, the following technical features (specific arrangement of structural alternatives of the support frame) are added to this embodiment: the bottom of the supporting frame and the mouse fixing device is provided with a bottom plate 1.
At least one T-shaped guide rail 2 is arranged at the first end of the bottom plate 1; optionally two T-shaped rails 2 are provided.
The T-shaped guide rail 2 is perpendicular to the shooting direction of the shooting device.
Two first fixed plates 3 are symmetrically arranged at the second end of the bottom plate 1, a first connecting rod 4 is arranged in the middle of the first fixed plate 3, and the support frame can move along the first connecting rod 4 so as to adjust the position of the photographing structure.
First fixed plate 3 and bottom plate 1 swing joint set up the guide rail along the direction of shooing on the bottom plate 1, set up the slider on the first fixed plate 3, have frictional force between slider and the guide rail, can not take place relative movement under non-manual operation, first fixed plate 3 can carry out back-and-forth movement along the direction of shooing, and above-mentioned setting does not need readjusting mouse fixing device to change the distance of shooting device, only need adjust support frame one side and can adjust to suitable position of shooing.
The support frame comprises a moving block 5, a first telescopic structure and a placing structure 6; the moving block 5 is fixedly connected with a telescopic structure, and the telescopic structure is movably connected with the placing structure 6; the above arrangement ensures that the position and angle of the placement structure 6 are adjustable.
The movable block 5 is in a cuboid shape, a first through hole is formed in the center of the movable block 5 and matched with the connecting rod, the movable block 5 is arranged on the connecting rod, friction force exists between the connecting rod and the first through hole, and position change cannot occur under non-manual operation.
The first telescopic structure comprises a first telescopic rod 7 and a second telescopic rod 8, wherein the first end of the first telescopic rod 7 is fixed on the moving block 5, the first telescopic rod 7 and the second telescopic rod 8 can be telescopic, the second end of the first telescopic rod 7 and the first end of the second telescopic rod 8 are fixedly connected, the diameter of the first end of the first telescopic rod 7 is the same as that of the first end of the second telescopic rod 8, the joint of the first telescopic rod 7 and the second telescopic rod 8 is in smooth connection, the included angle between the first telescopic rod 7 and the second telescopic rod 8 is 60-120 degrees, and preferably, the included angle between the first telescopic rod 7 and the second telescopic rod 8 is 90 degrees.
The second end of the second telescopic rod 8 is provided with a first circular groove, a first circular block 9 is arranged in the first circular groove, the first circular groove is movably connected with the first circular block 9, and friction force exists between the first circular groove and the first circular block 9.
The first round block 9 is provided with a first connecting rod 10, and the first connecting rod 10 is fixedly connected with the placement structure 6.
The inside recess that sets up to with the camera device adaptation of placing structure 6, camera device's latter half can be placed in placing structure 6.
When the device is used, a mouse is fixed on the mouse fixing device, when the mouse fixing device is set to be a simulated hand, the positions of the thumb and the index finger of the simulated hand are adjusted, the second hand is lifted, the mouse is placed on the first hand, the second hand is lowered to a proper position to fix the mouse, the photographing device is placed in the placing structure 6 of the supporting frame, the upper part of the photographing structure is matched with the fixing shell 12 on the light gathering amplifying structure, at the moment, a camera hole and a flash lamp hole in the light gathering tube 11 are matched with a camera and a flash lamp of the photographing device, the distance between the front mirror 16 and the light gathering tube 11 is adjusted until a clear image can be seen on the photographing device, and photographing and sampling are carried out through Bluetooth.
The above description of embodiments is only for the understanding of the present invention. It should be noted that it will be apparent to those skilled in the art that modifications can be made to the present invention without departing from the principles of the invention, and such modifications will fall within the scope of the claims.
Claims (4)
1. A photographing system for photographing the fundus of a mouse conveniently is characterized by comprising,
a photographing device for photographing an image of a fundus of a mouse;
the support frame is used for fixing the photographing device and can adjust the photographing device to a proper position;
a light condensing device for condensing the light of the photographing device to eyes of the mice;
the front mirror is used for being matched with the photographing device to obtain a clear image;
the mouse fixing device is used for fixing the mouse so that the mouse is in a stable state capable of being shot;
the photographing device is arranged in the supporting frame, the light condensing device is arranged at the lens end of the photographing structure, the light condensing device is detachably connected with the photographing structure, the front mirror is arranged on the light condensing device and is movably connected with the light condensing device, the mouse fixing device is arranged at a position opposite to the lens of the photographing device, and the distance between the mouse fixing device and the photographing device is adjustable; the light condensing device comprises a light condensing tube and a fixed shell; the light collecting pipe is fixedly connected with the fixed shell; the camera hole and the flash lamp hole in the light collecting tube are communicated with the fixed shell, the fixed shell is matched with the upper part of the photographing device, the fixed shell is separated from the photographing structure and fixed on the photographing structure, and the camera hole and the flash lamp hole in the light collecting tube are matched with the camera and the flash lamp of the photographing device; the movable ring is arranged on the light collecting pipe and is movably connected with the light collecting pipe; the first end of the movable ring is a taper section which is changed from small to large, at least one strip-shaped opening is formed along the direction in which the taper section is changed to large, threads are formed on the outer side of the taper section, a locking ring is arranged on the outer side of the taper section, and threads matched with the threads on the outer side of the taper section are formed on the inner side of the locking ring; the second end of the movable ring is provided with at least two arc-shaped rods, the front mirror is arranged on the inner side of the tail end of each arc-shaped rod, and the front mirror is fixedly connected with each arc-shaped rod; the mouse fixing device is provided with two simulated hands, the two simulated hands are formed by 3D printing, the shape of the simulated hands is the gesture of grabbing a mouse, and the mouse fixing device specifically comprises: the forefinger and the thumb of the first hand are in cross contact to support the head, the other three fingers support the body, the forefinger and the thumb of the second hand are placed behind the mouse ear, the forefinger and the thumb have the same posture as the first hand, and a fifth telescopic rod is arranged at the lower part of the second hand; the index finger and thumb of the two simulated hands are made of soft materials, and the two simulated hands are fixed on the bottom plate; the mouse fixing device comprises a placing plate, an upper supporting part and a fixing part; the upper supporting part and the fixing part are respectively fixed on the upper surface of the placing plate; the bottom surface of the placement plate is provided with at least one T-shaped groove, the T-shaped groove is matched with the T-shaped guide rail, and the placement plate can move along the T-shaped guide rail; a soft cushion is arranged at the center of the upper part of the placing plate, and a smooth protruding block is arranged at the center of the soft cushion; the first end of the placing plate is symmetrically provided with two second fixing plates, a second connecting rod is arranged in the middle of each second fixing plate, and the upper supporting part can move along the second connecting rod; the upper supporting part comprises a cylindrical block and upper supporting blocks, two upper supporting blocks are respectively arranged on the cylindrical block, and the upper supporting blocks are arranged on the upper part of the cylindrical block and are movably connected with the cylindrical block; the side surface of the cylindrical block is provided with a second through hole, the second through hole is matched with the second connecting rod, and friction force exists at the joint; the upper supporting block is cylindrical, a transverse rod is arranged on any side surface of the upper supporting block, and an inclined section is arranged on the transverse rod; the upper part of the cylindrical block is provided with a first round block, the upper part of the first round block is provided with a second round block, the diameter of the second round block is larger than that of the first round block, and the bottom of the upper supporting block is provided with a first groove and a second groove which are respectively matched with the first round block and the second round block; the fixing part comprises a second telescopic structure and a pressing block; the second telescopic structure is movably connected with the pressing block; the second telescopic structure and the pressing block are arranged in two groups, the two groups of images are arranged on two sides of the upper part of the placing plate, and the second telescopic structure is fixedly connected to the placing plate; the second telescopic structure comprises a third telescopic rod and a fourth telescopic rod, the first end of the third telescopic rod is fixed on the moving block, the third telescopic rod and the fourth telescopic rod can both be telescopic, the second end of the third telescopic rod is fixedly connected with the first end of the fourth telescopic rod, the diameters of the second end of the third telescopic rod and the first end of the fourth telescopic rod are the same, and the joint of the third telescopic rod and the fourth telescopic rod is in smooth connection; the second end of the fourth telescopic rod is provided with a second circular groove, a second circular block is arranged in the second circular groove, the second circular groove is movably connected with the second circular block, and friction force exists between the second circular groove and the second circular block; the second round block is provided with a second connecting rod which is fixedly connected with the pressing block; the pressing block is set to be a rectangular block, and a round angle is arranged at the lower part of the pressing block.
2. The photographing system for photographing fundus of mouse according to claim 1, wherein a bottom plate is arranged at the bottom of the supporting frame and the mouse fixing device; at least one T-shaped guide rail is arranged at the first end of the bottom plate; optionally two T-shaped guide rails are arranged; two first fixed plates are symmetrically arranged at the second end of the bottom plate, a first connecting rod is arranged in the middle of each first fixed plate, and the support frame can move along the first connecting rod.
3. The photographing system for facilitating photographing of a fundus of a mouse as claimed in claim 2, wherein the supporting frame comprises a moving block, a first telescopic structure and a placement structure; the moving block is fixedly connected with the telescopic structure, and the telescopic structure is movably connected with the placement structure; the movable block is in a cuboid shape, a first through hole is formed in the center of the movable block, the first through hole is matched with the connecting rod, the movable block is arranged on the connecting rod, and friction force exists between the connecting rod and the first through hole; the first telescopic structure comprises a first telescopic rod and a second telescopic rod, the first end of the first telescopic rod is fixed on the moving block, the first telescopic rod and the second telescopic rod can both be telescopic, the second end of the first telescopic rod is fixedly connected with the first end of the second telescopic rod, the diameters of the second end of the first telescopic rod and the first end of the second telescopic rod are the same, the joint of the first telescopic rod and the second telescopic rod is in smooth connection, and an included angle between the first telescopic rod and the second telescopic rod is 60-120 degrees; the second end of the second telescopic rod is provided with a first circular groove, a first circular block is arranged in the first circular groove, the first circular groove is movably connected with the first circular block, and friction force exists between the first circular groove and the first circular block; a first connecting rod is arranged on the first round block and is fixedly connected with the placement structure; the inside recess that sets up to be adapted with photographing device of placing structure.
4. A photographing system for photographing fundus of mice according to any of claims 1-3, wherein said second end of said placement plate is provided with a control cap, said control cap is rotatably connected to said placement plate, and the front and lower ends of said control cap are hollow.
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| CN202310759227.3A CN116649886B (en) | 2023-06-26 | 2023-06-26 | Photographing system convenient for photographing fundus of mouse |
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| CN202310759227.3A CN116649886B (en) | 2023-06-26 | 2023-06-26 | Photographing system convenient for photographing fundus of mouse |
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| CN116649886B true CN116649886B (en) | 2024-03-01 |
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| CN116649886A (en) | 2023-08-29 |
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