CN113974889A - Experimental animal fundus examination treatment equipment and application method thereof - Google Patents

Experimental animal fundus examination treatment equipment and application method thereof Download PDF

Info

Publication number
CN113974889A
CN113974889A CN202111428562.2A CN202111428562A CN113974889A CN 113974889 A CN113974889 A CN 113974889A CN 202111428562 A CN202111428562 A CN 202111428562A CN 113974889 A CN113974889 A CN 113974889A
Authority
CN
China
Prior art keywords
experimental animal
shaped block
block
piece
connecting piece
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202111428562.2A
Other languages
Chinese (zh)
Inventor
徐文荣
李兰
焦康为
柯红琴
董宇婕
曹倩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kunming Medical University
Original Assignee
Kunming Medical University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kunming Medical University filed Critical Kunming Medical University
Priority to CN202111428562.2A priority Critical patent/CN113974889A/en
Publication of CN113974889A publication Critical patent/CN113974889A/en
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D1/00—Surgical instruments for veterinary use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0075—Apparatus for testing the eyes; Instruments for examining the eyes provided with adjusting devices, e.g. operated by control lever
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/0083—Apparatus for testing the eyes; Instruments for examining the eyes provided with means for patient positioning
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
    • A61B3/1208—Multiple lens hand-held instruments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40—Animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00—Evaluating a particular growth phase or type of persons or animals
    • A61B2503/42—Evaluating a particular growth phase or type of persons or animals for laboratory research

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

The invention provides experimental animal fundus examination and treatment equipment, which relates to the technical field of animal fundus examination and comprises a first U-shaped block, wherein the front side and the rear side of the inner surface of one side of the first U-shaped block are respectively and rotatably connected with a first clamping arm, one side of the first U-shaped block is provided with a second U-shaped block, and through the arrangement of a sleeve, a sliding block, a rectangular block, a shell and a placing block, the sliding connection between the sleeve and the sliding block and the sliding connection between the rectangular block and the shell are facilitated. The device can be widely applied to the examination method of the vitreous body and the retina of an experimental animal, the manufacture of a retina neovascularization animal model, the injection treatment of medicaments into the vitreous cavity of the experimental animal and the like.

Description

Experimental animal fundus examination treatment equipment and application method thereof
Technical Field
The invention relates to the technical field of animal fundus examination, in particular to experimental animal fundus examination treatment equipment and an application method thereof.
Background
It is known that retinal detachment, diabetic retinopathy, retinal vein occlusion and other fundus diseases can seriously affect vision and even cause blindness. At present, a great deal of research work on these diseases is being widely carried out in animal experiments (such as rats, mice, rabbits, cats, dogs, pigs, monkeys, etc.) to investigate the disease mechanism and observe the efficacy of new treatment methods. The animal fundus operation under an operation microscope is the most basic method, and the recording of fundus changes under direct vision is the most important scientific evidence. At present, the common method is that a researcher holds a plane glass slide with one hand, presses the cornea under a microscope to see the eyeground of the animal clearly, and performs the operation of vitreous injection or subretinal injection with the other hand. Artificial operation can lead to the effect unstable like this, and be unfavorable for long-time detection treatment, consequently need supplementary relevant check out test set, and when present check out test set examined experimental animals, because the size of the required pupil of different animals is different, and current detection device size is relatively fixed, can not adjust according to the pupil size, leads to detecting inconveniently, influences the testing effect.
Disclosure of Invention
The invention aims to solve the problems that in the prior art, the sizes of pupils required by different animals are different, the size of the conventional detection device is relatively fixed and cannot be adjusted according to the size of the pupil, so that the detection is inconvenient and the detection effect is influenced, and provides experimental animal fundus examination treatment equipment and an application method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme: an experimental animal fundus examination treatment device comprises a first U-shaped block, wherein the front side and the rear side of the inner surface of one side of the first U-shaped block are respectively and rotatably connected with a first clamping arm, one side of the first U-shaped block is provided with a second U-shaped block, the front side and the rear side of the inner surface of one side of the second U-shaped block are respectively and rotatably connected with a second clamping arm, a screw thread is arranged at the center of the surface of one side of the first U-shaped block in a penetrating manner and is provided with an adjusting bolt, the number of the second clamping arms is two, the middle positions of the surfaces of the two second clamping arms are respectively and rotatably connected with the surfaces of the first clamping arms at the front side and the rear side, one side of the second clamping arm far away from the second U-shaped block is fixedly connected with a connecting piece, one side of the connecting piece far away from the second U-shaped block is provided with a moving piece, a rectangular groove is arranged at the center of one side of the connecting piece far away from the second U-shaped block, one side of the moving piece near the connecting piece is fixedly connected with a spring, the connecting piece is close to one side top position fixedly connected with sleeve of moving member, telescopic internal surface sliding connection has the slider, is located the front side position be provided with between connecting piece and the moving member and place the piece, the internal surface both sides position of placing the piece is threaded respectively and is run through and is provided with clamping bolt, and the surface bottom position both sides of placing the piece rotate respectively and are connected with the rectangular block, the surface sliding connection of rectangular block has the casing.
Preferably, the surface of the adjusting bolt penetrates through the center of the surface of the second U-shaped block, and the surface of the adjusting bolt and the second U-shaped block are rotatably arranged in a penetrating manner.
Preferably, one side of the outer surface of the moving part, which is close to the connecting part, is in sliding connection with the inner surface of the rectangular groove, and one end of the spring is fixedly connected with the inner surface of the rectangular groove.
Preferably, one side of the sliding block, which is far away from the connecting piece, is fixedly connected with the surface of the moving piece.
Preferably, one side of the bottom of the placing block is fixedly connected with a graduated scale.
Preferably, one side of the outer surface of each of the two shells, which is far away from the placing block, is rotatably connected with the surfaces of the sleeve and the sliding block respectively.
The invention also provides an application method of the experimental animal fundus examination treatment equipment, which is used for the experimental animal vitreous body and retina examination, the experimental animal retina laser treatment and retina ischemia, the retina neovascularisation animal model manufacture, the experimental animal vitreous body cavity injection medicine treatment field and the experimental animal subretinal injection treatment. The specific application method is as follows:
1. the experimental animal vitreous body and retina examination method comprises the following steps: after the experimental animal is anesthetized, compound tropicamide is used for mydriasis, the eyeground examination and treatment equipment for the experimental animal is used for opening the eyelid, a coupling agent is coated on the cornea, and a proper observation lens is selected for observation according to different animals; the vitreous body and retina of the experimental animal can be inspected and photographed under a stereoscopic microscope, the visual range of the retina can be enlarged by jointly using the episcleral depressor, and the peripheral retina can be observed and photographed.
2. The experimental animal retina laser treatment and retina ischemia, retina new vessel animal model making method:
(1) anaesthetizing the experimental animal, dispersing pupil by using compound tropicamide, opening the eyelid by using the eye fundus examination and treatment equipment for the experimental animal, coating a coupling agent on the cornea, and selecting a circular observation lens;
(2) placing the experimental animal under a slit lamp, adjusting the focal length to clearly observe the retina, and performing choroidal laser photocoagulation; during photocoagulation, attention is paid to avoid the great vessels of the retina, and after photocoagulation, a transitional phenomenon similar to bubble burst is generated on the retina without blood exudation, which indicates that photocoagulation is effective; the retina of each eye is equally divided into four areas, namely, an upper area, a lower area, a left area and a right area by taking the optic disc as the center, and each area is coagulated once.
(3) After laser photocoagulation, tobramycin eye ointment is smeared to protect the cornea, and after the experimental animal revives, the animal is returned to a breeding room.
3. The vitreous cavity injection medicine treatment method of the experimental animal comprises the following steps:
(1) anaesthetizing the experimental animal, performing mydriasis by using compound tropicamide, opening the eyelid by using the eye fundus examination and treatment equipment for the experimental animal, coating a coupling agent on the cornea, and selecting an oblique lens as an observation lens;
(2) preparing injection medicine, measuring the corneal limbus, inserting a needle, observing a needle head entering a vitreous cavity under a stereoscopic microscope, and injecting liquid medicine into the vitreous cavity; or a 30G needle is used under the guidance of an equipment ruler, is vertical to the surface of the eyeball, and is used for direct injection according to the depth of the needle;
(3) slightly pressing the needle inlet, smearing tobramycin eye ointment to protect the cornea, and returning the animal to the breeding room after the animal revives.
4. Experimental animal subretinal injection treatment:
(1) anaesthetizing the experimental animal, performing mydriasis by using compound tropicamide, opening the eyelid by using the eye fundus examination and treatment equipment for the experimental animal, coating a coupling agent on the cornea, and selecting a circular observation lens;
(2) the injection is prepared, the optic disc is found under a stereoscopic microscope, the corneal limbus is slightly close to the posterior needle, the needle insertion direction is 45 degrees to the iris surface, the needle is inserted into the subretinal space, when slight resistance is sensed, the liquid medicine is injected into the subretinal space, and the observation that the subretinal bulge is similar to the bubble shape indicates that the injection is successful.
(3) Slightly pressing the needle inlet, smearing tobramycin eye ointment to protect the cornea, and returning the experimental animal to the breeding room after the animal revives.
Compared with the prior art, the invention has the advantages and positive effects that,
1. according to the invention, the first U-shaped block, the second U-shaped block, the adjusting bolt, the first clamping arm, the second clamping arm and the connecting pieces are arranged, so that the adjusting bolt can be conveniently rotated to drive the second U-shaped block to move, the two second clamping arms which are rotatably connected with the second U-shaped block can be opened at an angle under the limiting action of the first clamping arm, the angle adjustment between the two connecting pieces is realized, namely, the distance adjustment is realized, meanwhile, the moving pieces slide in the rectangular grooves, so that the equipment can clamp lenses with different sizes, and the inspection of animal pupils with different sizes is realized.
2. According to the invention, through the arrangement of the sleeve, the sliding block, the rectangular block, the shell and the placing block, the sliding connection between the sleeve and the sliding block and the sliding connection between the rectangular block and the shell are facilitated, so that when the distance between the moving part and the connecting part is adjusted, the sliding block can conveniently rotate in the sleeve, the sliding of the rectangular block in the shell is realized, the position of the placing block is ensured to be fixed, namely, the placing block is ensured to be always aligned to the pupil of an animal, and the puncture is facilitated.
3. The device can be widely applied to the examination method of the vitreous body and the retina of an experimental animal, the manufacture of a retina neovascularization animal model, the injection treatment of medicaments into the vitreous cavity of the experimental animal and the like.
Drawings
FIG. 1 is a schematic structural view of an eye fundus examination treatment device for experimental animals according to the present invention;
FIG. 2 is a schematic view of a part of the structure of the fundus examination treatment apparatus for experimental animals of the present invention shown in FIG. 1;
fig. 3 is an enlarged view of the invention at a in fig. 2.
Illustration of the drawings: 1. adjusting the bolt; 2. a first U-shaped block; 3. a first clamp arm; 4. a second U-shaped block; 5. a second clamp arm; 6. a connecting member; 7. placing the blocks; 8. a moving member; 9. a sleeve; 10. a spring; 11. a rectangular groove; 12. a graduated scale; 13. a slider; 14. clamping the bolt; 15. a rectangular block; 16. a housing.
Detailed Description
In order that the above objects, features and advantages of the present invention can be more clearly understood, the present invention will be further described with reference to the accompanying drawings and examples. It should be noted that the embodiments and features of the embodiments of the present application may be combined with each other without conflict.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, however, the present invention may be practiced in other ways than those specifically described herein, and thus the present invention is not limited to the specific embodiments of the present disclosure.
Embodiment 1, as shown in fig. 1 to 3, an experimental animal fundus examination treatment apparatus comprises a first U-shaped block 2, a first clamping arm 3 is rotatably connected to the front and rear sides of the inner surface of one side of the first U-shaped block 2, a second U-shaped block 4 is arranged on one side of the first U-shaped block 2, a second clamping arm 5 is rotatably connected to the front and rear sides of the inner surface of one side of the second U-shaped block 4, an adjusting bolt 1 is disposed through the center of the surface of one side of the first U-shaped block 2, the surface of the adjusting bolt 1 is disposed through the center of the surface of the second U-shaped block 4, the surface of the adjusting bolt 1 and the second U-shaped block 4 are rotatably disposed, two second clamping arms 5 are disposed, the middle positions of the surfaces of the two second clamping arms 5 are rotatably connected to the surface of the first clamping arm 3 at the front and rear positions, a connecting member 6 is fixedly connected to one side of the second clamping arm 5 far from the second U-shaped block 4, one side that second U type piece 4 was kept away from to connecting piece 6 is provided with moving member 8, and connecting piece 6 keeps away from one side center department of second U type piece 4 and has seted up rectangular channel 11, and moving member 8 is close to one side fixedly connected with spring 10 of connecting piece 6, and one side that moving member 8's surface is close to connecting piece 6 and rectangular channel 11's internal surface sliding connection, the one end of spring 10 and the internal surface fixed connection of rectangular channel 11.
The whole embodiment 1 achieves the effects that the angle adjustment of the two first clamping arms 3 is conveniently realized through the rotary connection of the first clamping arms 3 and the first U-shaped block 2, the angle adjustment of the two first clamping arms 3 is realized through the arrangement of the second U-shaped block 4 and the two second clamping arms 5 which are rotatably connected with the second U-shaped block 4, meanwhile, as shown in figure 1, the adjacent two first clamping arms 3 and the second clamping arms 5 are rotatably connected, the position fixation of the second U-shaped block 4 is conveniently realized, namely the second U-shaped block 4 is prevented from rotating, and the smooth operation of the equipment is further straightened, the position fixation of the adjusting bolt 1 is conveniently realized through the rotary through connection of the adjusting bolt 1 and the second U-shaped block 4, namely, the adjusting bolt 1 can only realize the rotation and can not generate the relative movement with the second U-shaped block 4, and further, the relative movement of the adjusting bolt 1 and the first U-shaped block 2 is conveniently realized through the rotary through the threaded through the through connection of the adjusting bolt 1, and then realize the distance adjustment between second U type piece 4 and the first U type piece 2, and then realize the angle modulation of two second arm lock 5, and then realize the distance modulation between connecting piece 6, simultaneously through the sliding connection of rectangular channel 11 and moving member 8, be convenient for guarantee that moving member 8 and connecting piece 6 can only realize horizontal migration and can't rotate, realize the distance modulation between connecting piece 6 and the moving member 8 promptly, and then realize the centre gripping of the not equidimension lens, and through the spring 10 that sets up, be convenient for realize moving member 8 and the 6 pulling force supports of connecting piece through the elastic expansion of spring 10, when centre gripping lens promptly, prevent moving member 8 from sliding to breaking away from lens in rectangular channel 11, cause lens to drop.
Embodiment 2, as shown in fig. 1 to 3, a sleeve 9 is fixedly connected to a top position of one side of a connecting piece 6 close to a moving piece 8, a slider 13 is slidably connected to an inner surface of the sleeve 9, one side of the slider 13 far away from the connecting piece 6 is fixedly connected to a surface of the moving piece 8, a placing block 7 is arranged between the connecting piece 6 and the moving piece 8 at a front position, clamping bolts 14 are respectively arranged at two side positions of the inner surface of the placing block 7 in a threaded penetrating manner, a rectangular block 15 is respectively rotatably connected to two sides of a bottom position of the outer surface of the placing block 7, a housing 16 is slidably connected to the outer surface of the rectangular block 15, a scale 12 is fixedly connected to one side of the bottom of the placing block 7, and one side of the outer surfaces of the two housings 16 far away from the placing block 7 is respectively rotatably connected to surfaces of the sleeve 9 and the slider 13.
The whole embodiment 2 achieves the effects that the lens can be conveniently placed through the placing block 7, so that the personnel can conveniently observe and operate carefully during the needle puncture, and through the arranged clamping bolt 14, the clamping of the lens side edges with different thicknesses can be conveniently realized through rotating the clamping bolt 14, thereby ensuring that the position of the lenses of different sizes is fixed in the placing block 7, and the scale 12 is arranged to facilitate the control of the distance of the cornea from the puncture site, and through the sliding connection of the rectangular block 15 and the housing 16, the rectangular block 15 is rotatably connected with the placing block 7, and the two shells 16 are respectively rotatably connected with the surfaces of the sleeve 9 and the sliding block 13, so that when the connecting piece 6 and the moving piece 8 are angularly adjusted, the sliding block 13 and the sleeve 9 are driven to relatively slide, the rotation and relative sliding of the rectangular block 15 and the housing 16 are realized at the same time, so that the position of the placing block 7 is fixed.
The theory of operation, rotatory adjusting bolt 1 realizes that adjusting bolt 1 and first U type piece 2 take place relative movement, and then realize the distance adjustment between second U type piece 4 and the first U type piece 2, and then realize the angle modulation of two second arm lock 5, and then realize the distance modulation between connecting piece 6, during the centre gripping lens, pulling moving member 8 realizes that moving member 8 slides in rectangular channel 11 and realizes that spring 10 is tensile, and then realize the centre gripping of not unidimensional lens, through the clamp bolt 14 that sets up, be convenient for realize the rigidity of not unidimensional lens in placing piece 7 through rotatory clamp bolt 14, scale 12 that sets up is convenient for control cornea to the distance control of puncture position, and then the personnel of being convenient for operate.
Example 3, a method for making a laser-induced mouse CNV model:
(1) anaesthetizing the experimental mouse, dispersing pupil by using compound tropicamide, opening eyelids by using the eye fundus examination and treatment equipment for the experimental animal, coating a coupling agent on the cornea, and selecting a circular observation lens;
(2) placing the experimental animal under a slit lamp, adjusting the focal length to clearly observe the retina, and performing choroidal laser photocoagulation by selecting laser energy of 75-200mW, the diameter of a light spot of 75um and pulse of 90 ms; during photocoagulation, attention is paid to avoid the great vessels of the retina, and after photocoagulation, a transitional phenomenon similar to bubble burst is generated on the retina without blood exudation, which indicates that photocoagulation is effective; the retina of each eye is equally divided into four areas, namely, an upper area, a lower area, a left area and a right area by taking the optic disc as the center, and each area is coagulated once.
(3) After laser photocoagulation, tobramycin eye ointment is smeared to protect the cornea, and after the experimental animal revives, the animal is returned to a breeding room.
EXAMPLE 4 intravitreal drug infusion treatment in laboratory animals
(1) Anaesthetizing experimental monkeys, using compound tropicamide to perform mydriasis, using the experimental animal eye fundus examination treatment equipment to open eyelids, coating coupling agent on cornea, and selecting an oblique mirror as an observation lens;
(2) preparing injection medicine, selecting a needle with the diameter of 4mm behind the corneal limbus according to a scale on the device, observing a needle head entering a vitreous cavity under a stereoscopic microscope, and injecting liquid medicine into the vitreous cavity;
(3) slightly pressing the needle inlet, smearing tobramycin eye ointment to protect the cornea, and returning to the breeding room after the monkey revives.
The above description is only a preferred embodiment of the present invention, and not intended to limit the present invention in other forms, and any person skilled in the art may apply the above modifications or changes to the equivalent embodiments with equivalent changes, without departing from the technical spirit of the present invention, and any simple modification, equivalent change and change made to the above embodiments according to the technical spirit of the present invention still belong to the protection scope of the technical spirit of the present invention.

Claims (8)

1. An experimental animal eye ground examination treatment equipment, includes first U type piece (2), its characterized in that: the front side and the rear side of the inner surface of one side of the first U-shaped block (2) are respectively and rotatably connected with a first clamping arm (3), one side of the first U-shaped block (2) is provided with a second U-shaped block (4), the front side and the rear side of the inner surface of one side of the second U-shaped block (4) are respectively and rotatably connected with a second clamping arm (5), one side of the second clamping arm (5) far away from the second U-shaped block (4) is fixedly connected with a connecting piece (6), one side of the connecting piece (6) far away from the second U-shaped block (4) is provided with a moving piece (8), a rectangular groove (11) is formed in the center of one side of the connecting piece (6) far away from the second U-shaped block (4), one side of the moving piece (8) close to the connecting piece (6) is fixedly connected with a spring (10), and the top position of one side of the connecting piece (6) close to the moving piece (8) is fixedly connected with a sleeve (9), the interior surface sliding connection of sleeve (9) has slider (13), is located the front side position be provided with between connecting piece (6) and moving member (8) and place piece (7), bottom one side fixedly connected with scale (12) of placing piece (7), and the surface bottom position both sides of placing piece (7) rotate respectively and are connected with rectangular block (15), the surface sliding connection of rectangular block (15) has casing (16).
2. The experimental animal fundus examination treatment apparatus according to claim 1, characterized in that: the adjusting bolt (1) penetrates through the center of the surface of one side of the first U-shaped block (2), the surface of the adjusting bolt (1) penetrates through the center of the surface of the second U-shaped block (4), and the surface of the adjusting bolt (1) and the second U-shaped block (4) are arranged in a rotating and penetrating mode.
3. The experimental animal fundus examination treatment apparatus according to claim 1, characterized in that: the two second clamping arms (5) are arranged, and the middle positions of the surfaces of the two second clamping arms (5) are respectively connected with the surfaces of the first clamping arms (3) in the front and rear positions in a rotating mode.
4. The experimental animal fundus examination treatment apparatus according to claim 1, characterized in that: one side of the outer surface of the moving piece (8), which is close to the connecting piece (6), is in sliding connection with the inner surface of the rectangular groove (11), and one end of the spring (10) is fixedly connected with the inner surface of the rectangular groove (11).
5. The experimental animal fundus examination treatment apparatus according to claim 1, characterized in that: one side of the sliding block (13) far away from the connecting piece (6) is fixedly connected with the surface of the moving piece (8).
6. The experimental animal fundus examination treatment apparatus according to claim 4, wherein: and clamping bolts (14) are respectively arranged at the two sides of the inner surface of the placing block (7) in a threaded penetrating manner.
7. The experimental animal fundus examination treatment apparatus according to claim 5, wherein: one sides of the outer surfaces of the two shells (16) far away from the placing block (7) are respectively connected with the surfaces of the sleeve (9) and the sliding block (13) in a rotating way.
8. An application method of the experimental animal fundus examination treatment apparatus according to any one of claims 1 to 7, characterized in that: the experimental animal eye ground examination treatment equipment is used in the fields of experimental animal vitreous body and retina examination, experimental animal retina laser treatment and retina ischemia, retina neovascular animal model manufacturing, experimental animal vitreous cavity injection drug treatment and experimental animal subretinal injection treatment.
CN202111428562.2A 2021-11-29 2021-11-29 Experimental animal fundus examination treatment equipment and application method thereof Pending CN113974889A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202111428562.2A CN113974889A (en) 2021-11-29 2021-11-29 Experimental animal fundus examination treatment equipment and application method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202111428562.2A CN113974889A (en) 2021-11-29 2021-11-29 Experimental animal fundus examination treatment equipment and application method thereof

Publications (1)

Publication Number Publication Date
CN113974889A true CN113974889A (en) 2022-01-28

Family

ID=79732340

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202111428562.2A Pending CN113974889A (en) 2021-11-29 2021-11-29 Experimental animal fundus examination treatment equipment and application method thereof

Country Status (1)

Country Link
CN (1) CN113974889A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116649886A (en) * 2023-06-26 2023-08-29 苏州大学附属第一医院 Photographing system convenient for photographing fundus of mouse

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116649886A (en) * 2023-06-26 2023-08-29 苏州大学附属第一医院 Photographing system convenient for photographing fundus of mouse
CN116649886B (en) * 2023-06-26 2024-03-01 苏州大学附属第一医院 Photographing system convenient for photographing fundus of mouse

Similar Documents

Publication Publication Date Title
EP3223760B1 (en) Ocular therapeutics tool
Aihara et al. Experimental mouse ocular hypertension: establishment of the model
EP2109425B1 (en) Device for intraocular administration of a substance, for example a medication, into a human or animal eye by means of a hypodermic needle
US20100318034A1 (en) Device for intraocular administration of a substance, for example a medication, into a human or animal eye by means of a hypodermic needle.
GB2568370A (en) Ophthalmic delivery device
CN113974889A (en) Experimental animal fundus examination treatment equipment and application method thereof
Hirose et al. Simultaneous recording of electroretinogram and visual evoked response: focal stimulation under direct observation
CN105902341B (en) Medicine-filling device under Tenon capsule
NL2002379C2 (en) An ophthalmic device and an intravitreal method.
CN211356212U (en) Improved ophthalmic ball sub-fascia injection needle
Alamdar et al. Force and velocity based puncture detection in robot assisted retinal vein cannulation: in-vivo study
US11129604B2 (en) Scleral depression mechanical assist device
CN109568337B (en) Preparation method and application of keratitis animal model
WO2023001244A1 (en) Ophthalmic injection assembly and injection device, and use method
RU2563451C1 (en) System for subretinal dosing of stem cells
CN216417934U (en) Aqueous humor collecting device
CN216496017U (en) Needle head adapter and injection device for eyes
Hultman et al. A micro-advancer device for vitreal injection and retinal recording and stimulation
KR100431454B1 (en) Injector under The Retina
CN209770434U (en) Novel eyelid retractor
Parver Photochemical injury to the foveomacula of the monkey eye following argon blue-green panretinal photocoagulation.
CN216570448U (en) Injection needle for vitreous cavity gas-liquid exchange
CN113017983B (en) Cannula assembly and trocar system for posterior pole vitrectomy
US11666213B1 (en) Apparatus and method for the detection of dementia and retinal conditions
CN213217703U (en) Full femtosecond laser noninvasive accurate positioning marking tool

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication