CN116648513A - 切酶样敲除植物细胞 - Google Patents

切酶样敲除植物细胞 Download PDF

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CN116648513A
CN116648513A CN202180081013.4A CN202180081013A CN116648513A CN 116648513 A CN116648513 A CN 116648513A CN 202180081013 A CN202180081013 A CN 202180081013A CN 116648513 A CN116648513 A CN 116648513A
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plant cell
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plant
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尤里·哈纳尼亚
莫尔·舍瓦
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Protalix Ltd
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Abstract

提供了切酶样敲除植物细胞。因此，提供了悬浮的分离的植物细胞，其包含选自所述植物细胞中由DCL2、DCL4、RDR1、RDR2和RDR6所组成的组中的至少两个基因的所有等位基因中的功能缺失性突变。还提供了在植物细胞中消除选自由DCL2、DCL4、RDR1、RDR2和RDR6所组成的组中的至少两个基因的表达和/或活性的方法。

Description

切酶样敲除植物细胞
相关应用
本公开要求2020年10月5日提交的申请号为63/087,366的美国专利申请和2021年5月10日提交的申请号为63/186,280的美国专利申请的优先权，其全部公开内容通过引用并入本文。
序列表声明
与本公开同时提交的、创建于2021年10月5日文件名为89444SequenceListing.txt的ASCll的文件包括558,975字节，该文件通过引用并入本文。
技术领域与背景技术
本公开在其一些实施方式中涉及切酶样(DICER-LIKE)敲除植物细胞。
生产用于人类健康应用的植物蛋白具有一些优势，包括易于规模化以及没有人类和动物病原体(Donini和Marusic，2019；Loh等人，2017；Tekoah等人，2015)。第一种植物来源的药物重组蛋白于2012年获准在商业上应用于人类，第二种酶α-半乳糖苷酶-A用于治疗法布瑞氏症(Fabry disease)，目前正在进行III期临床试验(Kizhner等人，2015；Ruderfer等人，2018)。尽管取得了成功，但植物表达系统的特征是产量低，这是基因沉默(genesilencing)的结果，基因沉默是控制基因表达、发育调控和表观遗传修饰的基本调节和防御机制之一(Baulcombe,2004；Moazed,2009)。
RNA干扰通过与RNA指导的DNA甲基化(DNA methylation，RdDM)进行的DNA修饰相关的转录基因沉默(transcriptionally gene silencing，TGS)或通过与mRNA降解或阻断RNA转录本翻译的RNA修饰相关的转录后基因沉默(post-transcriptional genesilencing，PTGS)发生。在这两种情况下，都会产生长度为21nt至24nt的小RNA(siRNA)分子。已知几种蛋白质参与这些过程。RNA依赖性RNA聚合酶(RNA-dependent RNApolymerases，RDRs)是一个蛋白质家族，它使用异常的单链RNA，例如病毒RNA或转基因衍生的mRNA作为模板，产生双链RNA(double-stranded RNA，dsRNA)分子。植物中称为切酶样(DICER like，DCL)的内切核糖核酸酶(endoribonuclease，RNase III)由长双链RNA或发夹环结构的RNA(hairpin-loop-structured RNAs)产生siRNAs或miRNAs(21nt至24nt)(Ji，2008)。dsRNA-结合蛋白将Dicer-siRNA复合物募集到Argonaute(Ago)蛋白家族，Ago切割siRNA双链体的抗-导向链(anti-guide strand)(Hammond等人,2001)。剩余的单链(single-stranded，ss)反义siRNA(antisense siRNA)与Ago一起与其他RNA结合蛋白结合，组装成RNA诱导沉默复合物(RNA-induced silencing complex，RISC)(Martinez等人，2002)。在细胞质中，mRNA靶可以经由RISC切片机活性被Ago切割以沉默靶基因，称为PTGS(Rand等人，2005)。在细胞核中，RISC可以采用RNA诱导的转录沉默(RNA-inducedtranscriptional silencing，RITS)复合物的形式，其与RNA聚合酶II(PolII)和新生RNA转录物相互作用，并指导染色质重塑以通过RdDM实现表观遗传学沉默(Pratt和MacRae，2009；Verdel等人，2004)。
植物基因组包含至少四类不同的DCL家族蛋白(DCL 1-4)，它们在基因沉默中起重要作用。如同它们的动物对应物一样，每一类DCL都参与特定的功能(Fukudome和Fukuhara，2016)。DCL1从miRNA前体产生21个核苷酸(nucleotides，nt)长的SiRNA，所述miRNA前体由非编码基因转录(Choudhary等人，2019)。DCL3的主要活性是将来自基因组异色区的长dsRNA加工成24个核苷酸(24-nt)siRNA。然后这些分子指导靶序列的DNA甲基化(Blevins等人，2015)。DCL2和DCL4参与病毒诱导的RNA沉默(virus induced RNA silencing，VIGS)和转基因沉默。DCL2产生22个核苷酸(nt)的siRNA,DCL4负责21个核苷酸(21-nt)的siRNA(Chen等人，2018；Parent等人，2015)。
植物基因组包含6个RDR，分为两组：RDR1、RDR2和RDR6组成的RDRα，以及RDR3、RDR4和RDR5组成的RDRγ。RDR1、RDR2和RDR6基因共有(share)真核RDR的C-末端典型催化DLDGD(SEQ ID NO:32)基序，其参与植物抗病毒和转基因沉默(Wassenegger和Krczal,2006)。
在植物中实施诱导突变和RNAi技术以敲除参与沉默的DCL或RDR基因(例如，Daxinger等人，2008；Parent等人，2015年；Seta等人，2017；Yoshikawa等人，2005年；Konstantina Katsarou等人，分子植物病理学(Mol Plant Pathol.)，2019年3月，20(3):432-446；Matsuo和Matsumura，2017；Qin等人，2017；Suzuki等人，2019；Deleris等人，科学(Science)，2006年7月7日，313(5783):68-71；Xie等人，美国国家科学院院刊(Proc NatlAcad Sci U S A)，2005年9月6日，102(36):12984-12989；Hernan Garcia-Ruiz等人，植物细胞(Plant Cell)，2010年2月，22(2):481-496；Polydore S和Axtell MJ(2018)，植物学杂志(The Plant Journal)，94:1051-1063；Matsuo和Atsumi G(2019)，植物科学(Planta)，250:463-473；国际专利申请公开号WO2015054602和WO2019222379；以及美国专利申请公开号US20120240288和US20100050294)。值得注意的是，这些研究中很少显示DCL抑制导致明显的发育缺陷和对某些RNA病毒更高的易感性。
发明内容
根据本公开的一些实施方式的一个方面，提供了一种悬浮的分离的植物细胞，其包含选自植物细胞中由DCL2、DCL4、RDR1、RDR2和RDR6所组成的组中的至少两个基因的所有等位基因中的功能缺失性突变。
根据本公开的一些实施方式，DCL2中的功能缺失性突变位于植物细胞中DCL2的所有等位基因共有的区域中。
根据本公开的一些实施方式，DCL2中的功能缺失性突变位于对应于SEQ ID NO:74的核酸残基288-307和/或881-900内；和/或对应于SEQ ID NO:75的核酸残基288-307和/或881-900内。
根据本公开的一些实施方式，DCL2基因的所有等位基因共有的区域包含选自SEQID NO:1-2的序列。
根据本公开的一些实施方式，DCL4中的功能缺失性突变位于植物细胞中的DCL4的所有等位基因共有的区域中。
根据本公开的一些实施方式，DCL4中的功能缺失性突变位于对应于SEQ ID NO:76的核酸残基967-986和/或1407-1426内；和/或对应于SEQ ID NO:77的核酸残基931-950和/或1371-1390内。
根据本公开的一些实施方式，DCL4基因的所有等位基因共有的区域包含选自SEQID NO:3-4的序列。
根据本公开的一些实施方式，RDR1中的功能缺失性突变位于植物细胞中由RDR1的所有等位基因共有的区域中。
根据本公开的一些实施方式，RDR1中的功能缺失性突变位于对应于SEQ ID NO:78的核酸残基916-937和/或962-984内；和/或对应于SEQ ID NO:79的核酸残基921-937和/或962-984内。
根据本公开的一些实施方式，RDR1基因的所有等位基因共有的区域包含选自SEQID NO:26-27的序列。
根据本公开的一些实施方式，RDR2中的功能缺失性突变位于植物细胞中RDR2的所有等位基因共有的区域中。
根据本公开的一些实施方式，RDR2中的功能缺失性突变位于对应于SEQ ID NO:80的核酸残基575-553和/或589-612内；和/或对应于SEQ ID NO:81的核酸残基575-553和/或589-612内。
根据本公开的一些实施方式，RDR2基因的所有等位基因共有的区域包含选自SEQID NO:28-29的序列。
根据本公开的一些实施方式，RDR6中的功能缺失性突变位于植物细胞中RDR6的所有等位基因共有的区域中。
根据本公开的一些实施方式，RDR6中的功能缺失性突变位于对应于SEQ ID NO:82的核酸残基2767-2785和/或2820-2839内；对应于SEQ ID NO:83的核酸残基49-67和/或102-121；和/或对应于SEQ ID NO:84的核酸残基49-67和/或102-121内。
根据本公开的一些实施方式，RDR6基因的所有等位基因共有的区域包含选自SEQID NO:30-31的序列。
根据本公开的一些实施方式，与具有相同遗传背景但未用下调糖基化酶表达和/或活性的试剂的对照植物细胞相比，该植物细胞具有降低的糖基化酶表达和/或活性。
根据本公开的一些实施方式，所述分离的植物细胞包含用于表达目标表达产物(expression product of interest)的异源核酸序列。
根据本公开的一些实施方式的一个方面，提供了一种在植物细胞中表达目标重组表达产物的方法，该方法包括在允许目标表达产物表达的条件下培养细胞。
根据本公开的一些实施方式的一个方面，提供了一种消除选自植物细胞中由DCL2、DCL4、RDR1、RDR2和RDR6所组成的组中至少两个基因的表达和/或活性的方法，所述方法包括向悬浮的分离的植物细胞中引入一种试剂，所述试剂能够在选自植物细胞中由DCL2、DCL4、RDR1、RDR2和RDR6所组成的组中至少两个基因的所有等位基因中引入功能缺失性突变。
根据本公开的一些实施方式，该方法包括向分离的植物细胞中引入能够下调糖基化酶的表达和/或活性的试剂。
根据本公开的一些实施方式，与具有相同遗传背景但未用下调糖基化酶表达和/或活性的试剂的对照植物细胞相比，该植物细胞具有降低的糖基化酶表达和/或活性。
根据本公开的一些实施方式，所述糖基化酶包括木糖基转移酶和/或岩藻糖基转移酶。
根据本公开的一些实施方式，所述试剂是基因组编辑试剂。
根据本公开的一些实施方式，所述基因组编辑试剂选自CRISPR/Cas系统、锌指核酸酶(Zinc finger nuclease，ZFN)、转录激活因子样效应物核酸酶(transcription-activator like effector nuclease，TALEN)或巨核酸技术(meganuclease)。
根据本公开的一些实施方式，所述试剂包含DCL2 DNA靶向序列，所述DCL2 DNA靶向序列包含选自由SEQ ID NO:1-2所组成的组的核酸序列。
根据本公开的一些实施方式，所述试剂包含DCL4DNA靶向序列，所述DCL4DNA靶向序列包含选自由SEQ ID NO:3-4所组成的组的核酸序列。
根据本公开的一些实施方式，所述试剂包含RDR1 DNA靶向序列，该RDR1 DNA靶向序列包含选自由SEQ ID NO:26-27所组成的组的核酸序列。
根据本公开的一些实施方式，所述试剂包含RDR2 DNA靶向序列，该RDR2 DNA靶向序列包含选自由SEQ ID NO:28-29所组成的组的核酸序列。
根据本公开的一些实施方式，所述试剂包含RDR6 DNA靶向序列，该RDR6 DNA靶向序列包含选自由SEQ ID NO:30-31所组成的组的核酸序列。
根据本公开的一些实施方式，所述方法还包括在分离的植物细胞中表达除所述试剂以外的目标重组表达产物。
根据本公开的一些实施方式，通过RT-PCR测定，功能缺失性突变消除了至少两个基因的表达。
根据本公开的一些实施方式，所述功能缺失性突变消除了DCL2和DCL4的表达和/或活性，这是通过转基因在植物细胞中表达后，转基因特异性21-nt和22-nt siRNAs在植物细胞中不表达来确定的。
根据本公开的一些实施方式，所述植物选自由烟草(Tobacco)、拟南芥、芦荟、葡萄籽、油棕、车前草、松树、香蕉、大枣、茄子、荷荷巴(jojoba)、菠萝、橡胶树、木薯、山药、甘薯和番茄所组成的组。
根据本公开的一些实施方式，所述植物是烟草(Tobacco)植物。
根据本公开的一些实施方式，所述烟草(Tobacco)是烟叶(Nicotiana tabacum)。
根据本公开的一些实施方式，所述植物细胞是BY-2系细胞(BY-2 line cell)。
除非另有限定，否则本文中使用的所有技术和/或科学术语具有与本公开所属领域的普通技术人员通常理解的含义相同的含义。尽管可以在本公开的实施方式的实践或测试中使用与本文描述的那些类似或等同的方法和材料，但是下面描述了示例性方法和/或材料。如有冲突，以专利说明书(包括限定)为准。此外，这些材料、方法和实施例仅是说明性的，并不意味着必须是限制性的。
附图简要说明
本文通过示例的方式参考附图描述了本公开的一些实施方式。现在详细地具体参考附图，需要强调的是，所示的细节是示例性的，并且是为了说明性地讨论本公开的实施方式。在这点上，结合附图所作的描述使得本领域技术人员清楚如何实施本公开的实施方式。
在附图中：
图1A-C示出了用于敲除DCL2和DCL4基因的CRISPR-Cas9载体的示意图。图1A示出了phCas9-DCL2载体；图1B示出了phCas9-DCL4载体；图1C示出了phCas9-DCL2-DCL4载体。LB-左边框；IRES-内部核糖体进入位点；hptII-潮霉素磷酸转移酶II；Nter-胭脂碱合成酶终止子(Nopaline synthase terminator)；35S-具有ω增强子的35s花椰菜花叶病毒启动子；hCas9-具有SV40核定位信号的人类优化的Cas9(Nekrasov等人，2013)；Oter-章鱼碱合酶终止子(Octopine synthase terminator)；U6-拟南芥U6启动子；sgRNA1-4-各种crRNAs与tracrRNA的嵌合体，代表了用于敲除DCL2(gRNA1,2)和DCL4(gRNA3,4)基因的四个不同的crRNA。
图2示出了相对于系40(line 40)，重组拉布立酶(recombinant rasburicase)在所示的ΔD2ΔD4、ΔD2和ΔD4混合细胞(pooled cells)中的表达水平，如通过蛋白质活性测定所确定的。系40ΔD2ΔD4-用phCas9-DCL2-DCL4载体转化的系40细胞的池(pool)。该池包含部分DCL2和DCL4基因的敲除细胞。系40ΔD2-用phCas9-DCL2载体转化的系40细胞的池。该库部分包含DCL2基因的敲除细胞。系40ΔD4-用phCas9-DCL4载体转化的系40细胞的池。该池包含部分DCL4基因的敲除细胞。系40-表达重组拉布立酶的原始系(originalline)，用于转化以敲除DCL2和/或DCL4基因。实验重复3次。误差线表示标准误差偏差。
图3示出了通过蛋白质活性测定所确定的，相对于系40，重组拉布立酶在所示的ΔD2ΔD4系(从混合的ΔD2ΔD4细胞中分离)中的表达水平。
图4示出了通过蛋白质活性测定所确定的，相对于系40，重组拉布立酶在所示ΔD2系(从混合的ΔD2细胞中分离)中的表达水平。
图5A-B示出了用于检测DCL2中的基因插入或删除(indel)的扩增片段长度多态性(amplification fragment length polymorphism，AFLP)测定。图5A是PCR扩增方案的示意图。FP-正向引物。RP-反向引物。图5B是DNA凝胶图像，示出了与ΔD2ΔD4系3、18、34、58、65相比，从野生型BY2细胞(104bp)获得的PCR扩增子。M-DNA 100bp梯状条带(ladder)。
图6A-B示出了DCL4的限制性片段长度多态性(restriction fragment lengthpolymorphism，RFLP)测定。图6A是包含在DCL4-gRNA3位点(加下划线的字母，SEQ ID NO:3)中的EcoNI位点(斜体和粗体)的示意图，后面是PAM序列(GGG)。箭头所示的EcoNI位点上游和下游的一对引物用于靶DNA基因座(locus)的PCR扩增。FP-正向引物。RP-反向引物。图6B是DNA凝胶图像，示出了与ΔD2ΔD4系3、18、34、58、65相比，从野生型BY2细胞(189bp和89bp)获得的EcoNI消化的扩增子的模式。M-DNA标记物(左边表示尺寸)。
图7A-B示出了ΔD2ΔD4系18中DCL2和DCL4基因的突变。突变的DCL2基因的测序(图7A)和突变的DCL4基因的测序(图7B)。野生型基因的序列用大写字母表示，突变等位基因的序列在下方用小写字母表示。cas9靶位点序列带有下划线。删除用破折号表示，插入用大写字母表示。箭头表示精确的切割位点。插入或删除(indels)的大小以bp表示在右边。
图8A-B示出了ΔD2ΔD4系65中DCL2和DCL4基因的突变。突变的DCL2基因的测序(图8A)和突变的DCL4基因的测序(图8B)。野生型基因的序列用大写字母表示，突变等位基因的序列在下方用小写字母表示。cas9靶位点序列带有下划线。删除用破折号表示，插入用大写字母表示。箭头表示精确的切割位点。插入或删除(indels)的大小以bp表示在右边。
图9A-C表明重组拉布立酶表达的增加归因于DCL2和DCL4基因的敲除。图9A示出了相对于系40，重组拉布立酶在所示的ΔD2和ΔD2ΔD4系中的表达水平，如通过蛋白质活性测定所确定的。图9B示出了小干扰RNA(siRNA)的检测。分离原始系40或所示的ΔD2或ΔD2ΔD4系的总siRNA，并用拉布立酶RNA探针杂交。上图显示杂交信号。下图显示用溴化乙锭染色的加载对照(主要是tRNA)。使用特异性拉布立酶梯状条带在左侧显示siRNA大小。图9C示出了相对于系40，拉布立酶mRNA在所示的ΔD2ΔD4系中的表达水平，如使用糖基转移酶基因作为管家基因通过实时RT-PCR所确定的。
图10A-B示出了用于检测DCL2中的插入或删除(indel)的扩增片段长度多态性(AFLP)测定。图10A是PCR扩增方案的示意图。FP-正向引物。RP-反向引物。图10B是DNA凝胶图像，示出了与ΔD2ΔD4系5、35、71、93、97、103相比，从野生型BY2细胞(104bp)获得的PCR扩增子。M-DNA 100bp梯状条带。左边表示尺寸。
图11A-B示出了DCL2的限制性片段长度多态性(RFLP)测定。图11A是包含在DCL2-gRNA2位点(加下划线的字母，SEQ ID NO:2)中的PspFI位点(斜体和粗体)的示意图，后面是PAM序列(TGG)。箭头所示的PspFI位点上游和下游的一对引物用于靶DNA基因座的PCR扩增。FP-正向引物。RP-反向引物。图11B是DNA凝胶图像，示出了与ΔD2ΔD4系5、35、71、93、97和103相比，从野生型BY2细胞(189bp和529bp)获得的PspFI消化的扩增子的模式。M-DNA标记物(左边表示尺寸)。
图12A-B示出了DCL4的限制性片段长度多态性(RFLP)测定。图12A是包含在DCL4-gRNA3位点(加下划线的字母，SEQ ID NO:3)中的EcoNI位点(斜体和粗体)的示意图，后面是PAM序列(GGG)。箭头所示的EcoNI位点上游和下游的一对引物用于靶DNA基因座的PCR扩增。FP-正向引物。RP-反向引物。图12B是DNA凝胶图像，示出了与ΔD2ΔD4系5、35、71、93、97和103相比，从野生型BY2细胞(189bp和89bp)获得的EcoNI消化的扩增子的模式。M-DNA标记物(左边表示尺寸)。
图13A-B示出了ΔD2ΔD4系35中DCL2和DCL4基因的突变。突变的DCL2基因的测序(图13A)和突变的DCL4基因的测序(图13B)。野生型基因的序列用大写字母表示，突变等位基因的序列在下方用小写字母表示。cas9靶位点序列带有下划线。删除用破折号表示。箭头表示精确的切割位点。插入或删除(indels)的大小以bp表示在右边。
图14A-B示出了相对于40系，重组拉布立酶在ΔD2ΔD4、ΔD2和ΔD4混合细胞中的表达水平。用拉布立酶BeYDV载体转化推定的DCL2和DCL4敲除系5、35、71、93、97、103和野生型BY2，并分析每种转化的池。图14A示出了通过活性测定所确定的拉布立酶的表达水平。实验重复3次。误差线表示标准误差偏差。图14B示出了通过考马斯蓝染色的总蛋白的SDS-PAGE测定的拉布立酶的表达水平。Std-1μg重组拉布立酶。N.C-未转化的BY2，用作阴性对照。BY2-用拉布立酶转化的野生型BY2细胞。系5、35和93-用拉布立酶转化的DCL2和DCL4敲除系。以千道尔顿(kilo Daltons)为单位的分子大小显示在左边。
图15表明重组拉布立酶表达的增加归因于DCL2和DCL4基因的敲除。分离用拉布立酶转化的BY2或所示的ΔD2ΔD4系的总siRNA，并用拉布立酶RNA探针杂交。N.C-未转化的BY2用作阴性对照。上图显示杂交信号。下图显示用溴化乙锭染色的加载对照(主要是tRNA)。使用特异性拉布立酶梯状条带在左侧显示siRNA大小。
图16是本发明人使用的针对特定靶序列的crRNA设计的示意图。
具体实施方式
本公开在其一些实施方式中涉及切酶样敲除植物细胞。
在详细解释本公开的至少一个实施方式之前，应当理解的是，本公开在其应用中不一定局限于在下面的描述中阐述的或者由实施例示出的细节。本公开能够有其他实施方式，或者能够以各种方式实践或执行。
在植物中生产重组蛋白有许多优点。然而，由于基因沉默，植物表达系统的特征是产量低。植物切酶样(DCL)和RNA依赖性RNA聚合酶(RDRs)蛋白是参与基因沉默的关键成分。
在将本公开的具体实施方式付诸实践的同时，本发明人现在已经得到了DCL2-和DCL4敲除植物细胞。此外，与它们的野生型对应物相比，这些细胞表达较高量的重组蛋白。
具体地，本发明人使用CRISPR/Cas9技术开发了DCL2-和DCL4敲除烟叶(Nicotianatabacum)BY2细胞，其在所有基因等位基因中完全突变(以下实施例部分的实施例1-3)。这些敲除的BY2细胞是可存活的，并且它们的生长速率类似于天然BY2细胞。此外，与野生型细胞中的表达水平相比，重组蛋白(拉布立酶)在DCL2-和DCL4敲除细胞系中的表达水平高达10倍。本发明人证实了DCL2-和DCL4敲除与重组蛋白表达增加之间的相关性，表明敲除系不产生转基因特异性21bp和22bp siRNA。
因此，本发明的具体实施方式提出了分离的DCL2-和DCL4敲除植物细胞及其产生方法。随后，这些新的植物细胞可用于例如重组蛋白质的表达。
因此，根据本公开的一个方面，提供了一种消除选自植物细胞中由DCL2、DCL4、RDR1、RDR2和RDR6所组成的组中的至少两个基因的表达和/或活性的方法，所述方法包括向悬浮的分离的植物细胞中引入一种试剂，该试剂能够在选自植物细胞中由DCL2、DCL4、RDR1、RDR2和RDR6所组成的组中至少两个基因的所有等位基因中引入功能缺失性突变。
根据具体实施方式，所述至少两个基因至少包括DCL2和DCL4、DCL2和RDR1、DCL2和RDR2、DCL2和RDR6、DCL4和RDR1、DCL4和RDR2、DCL4和RDR6、RDR1和RDR2、RDR1和RDR6、或RDR2和RDR6，每种可能性代表本公开的单独的实施方式。
根据具体的实施方式，所述至少两个基因包含至少三个基因、至少四个基因或全部5个基因。
根据具体实施方式，所述至少三个基因至少包含DCL2+DCL4+RDR1、DCL2+DCL4+RDR2、DCL2+DCL4+RDR6、DCL2+RDR1+RDR2、DCL2+RDR1+RDR6、DCL2+RDR2+RDR6、DCL4+RDR1+RDR2、DCL4+RDR1+RDR6。DCL4+RDR2+RDR6,RDR1+RDR2+RDR6，每种可能性代表本公开的单独的实施方式。
该试剂可以是靶向不同基因的单一试剂或各自靶向至少一种基因的几种不同试剂。
因此，根据具体的实施方式，所述试剂包含至少两种、至少三种、至少四种或至少五种不同的试剂。
DCL(切酶样)是属于RNase III家族的内切核糖核酸酶。DCL酶将双链RNA(double-stranded RNA，dsRNA)或发夹环结构的RNA和前体miRNA(pre-microRNA，pre-miRNA)切割成短的单链RNA片段，分别称为小干扰RNA和微小核糖核酸(microRNA)。植物基因组含有至少四种不同种类的DCL家族蛋白。
如本文所用，术语“DCL2”是指编码核内切核糖核酸酶切酶样2的基因。DCL2从有助于病毒免疫和防御的顺式作用反义转录物种产生22-nt长的siRNA。
例如，烟草(Nicotiana tabacum)TN90包含两个DCL2基因，它们的序列可以从已知的数据库如Solgenomics(www.solgenomics.net)中获得。
示例性重叠群(contigs)包括：
N.tab-DCL2A NW_015902585(SEQ ID NO:63)和
N.tab-DCL2B NW_015936378(SEQ ID NO:64)。
烟草(Nicotiana tabacum)DCL2A和DCL2B的示例性cDNA序列分别在SEQ ID NO:74和75中提供。
如本文所用，术语“DCL4”是指编码内切核糖核酸酶切酶样4的基因。DCL4参与转录后水平的反式作用siRNA代谢和转录本沉默，并产生21-nt长的siRNA。
例如，烟草TN90包含两个DCL4基因，它们的序列可以从已知的数据库如Solgenomics(www.solgenomics.net)中获得。示例性重叠群包括：
N.tab-DCL4A NW_015930707(SEQ ID NO:65)和
N.tab-DCL4B NW_015939689(SEQ ID NO:66)。
烟草(Nicotiana tabacum)DCL2A和DCL2B的示例性cDNA序列分别在SEQ ID NO:76和77中提供。
RNA依赖性RNA聚合酶(RDR)，也称为RNA复制酶，EC NO:2.7.7.48，是一种催化RNA模板复制RNA的酶。真核RDRs有三个主要分支-RDRα、RDRβ和RDRγ，而RDRβ可能在植物谱系(plant lineage)中丢失。植物基因组含有至少6个RDR家族蛋白。RDRα基因已经在植物中复制以产生单独的RDR1、RDR2和RDR6亚群(subgroups)，RDRγ基因已经复制以产生RDR3、RDR4和RDR5亚群[Zong等人，(2009),基因(Gene)447:29-39]。
如本文所用，术语“RDR1”是指编码RNA依赖性RNA聚合酶1的基因。RDR1参与病原体抗性和应激反应。RDR1有助于产生vsRNAs(21-nt、22-nt)和通过这些vsRNAs赋予的抗病毒防御。
例如，烟草(Nicotiana tabacum)TN90包含2种RDR1基因，它们的序列可以从已知的数据库如Solgenomics(www.solgenomics.net)中获得。示例性重叠群包括：
N.tab-RDR1A NTAB-TN90_AYMY-SS286(SEQ ID NO:67)和
N.tab-RDR1B NTAB-TN90_AYMY-SS10620(SEQ ID NO:68)。
烟草(Nicotiana tabacum)RDR1A和RDR1B的示例性cDNA序列分别在SEQ ID NO:78和79中提供。
如本文所用，术语“RDR2”是指编码RNA依赖性RNA聚合酶2的基因。RDR2参与转基因沉默，并且对于内源性siRNA的生物发生(雌配子形成、基因组维护等)是必需的。它导致24-nt和胞嘧啶甲基化、组蛋白修饰和RNA指导的DNA甲基化(RNA-directed DNA methylation，RdDM)的形成。
例如，烟草(Nicotiana tabacum)TN90包含2种RDR2基因，它们的序列可以从已知的数据库如Solgenomics(www.solgenomics.net)中获得。示例性重叠群包括：
N.tab-RDR2A Nitab4.5_0006831(SEQ ID NO:69)和
N.tab-RDR2B Nitab4.5_0010542(SEQ ID NO:70)。
烟草(Nicotiana tabacum)RDR2A和RDR2B的示例性cDNA序列分别在SEQ ID NO:80和81中提供。
如本文所用，术语“RDR6”是指编码RNA依赖性RNA聚合酶6的基因。RDR6参与反式作用干扰小RNA(tasiRNAs)和天然反义干扰小RNA(siRNAs)的产生，并且还被发现对于正义转基因诱导的转录后基因沉默(sense transgene-induced posttranscriptional genesilencing，S-PTGS)是必需的。RDR6有助于通过这些vsRNAs(21-nt、24-nt)赋予的抗病毒防御。
例如，烟草(Nicotiana tabacum)TN90包含3种RDR6基因，它们的序列可以从已知的数据库如Solgenomics(www.solgenomics.net)中获得。示例性重叠群包括：
N.tab-RDR6A NTAB-TN90_AYMY-SS110011(SEQ ID NO:71)；
N.tab-RDR6B NTAB-TN90_AYMY-SS48576(SEQ ID NO:72)；和
N.tab-RDR6C NTAB-TN90_AYMY-SS1589(SEQ ID NO:73)。
烟草(Nicotiana tabacum)RDR6A、RDR6B和RDR6C的示例性cDNA序列分别在SEQ IDNOs:82、83和84中提供。
如本文所用，术语“分离的植物细胞(isolated plant cell)”是指至少部分地与天然植物(或其部分)分离的植物细胞。
在一些实施方式中，分离的细胞是悬浮培养物中的植物细胞。
悬浮培养是指细胞不是组织的一部分，而是在培养基中作为单细胞或不超过100个细胞的细胞群漂浮在培养基中。
用于悬浮培养植物细胞的合适装置和方法是本领域已知的，例如，如国际专利申请PCT IL2008/000614中所述。
可用于本公开方法的植物的非限制性示例包括属于绿色植物(Viridiplantae)总科的所有植物，特别是单子叶和双子叶植物，包括饲料或饲料豆科植物、观赏植物、食物作物、树木或选自包括下表的灌木：金合欢属(Acacia spp.)、槭属(Acer spp.)、猕猴桃属(Acer spp.)、七叶树属(Aesculus spp.)、南方贝壳杉(Agathis australis)、苦合欢(Albizia amara)、三色桫椤属(Alsophila tricolor)、须芒草属(Andropogon spp.)、落花生属(Arachis spp)、槟榔(Areca catechu)、香桂(Astelia fragrans)、鹰嘴紫云英(Astragalus cicer)、罗得西亚柚木(Baikiaea plurijuga)、桦木属(Betula spp.)、芸苔属(Brassica spp.)、木榄(Bruguiera gymnorrhiza)、伯克苏木(Burkea africana)、甄叔迦树(Butea frondosa)、卡达巴木(Cadaba farinosa)、朱缨花属(Calliandra spp)、茶属(Camellia sinensis)、大麻科(Cannabaceae)、印度大麻(Cannabis indica)、大麻属(Cannabis)、大麻(Cannabis sativa)、大麻(Hemp)、工业大麻(industrial Hemp)、辣椒属(Capsicum spp.)、决明属(Cassia spp.)、巨瓣豆(Centroema pubescens)、木瓜属(Chacoomeles spp.)、肉桂(Cinnamomum cassia)、阿拉比卡咖啡(Coffea arabica)、可乐豆(Colophospermum mopane)、多变小冠花(Coronillia varia)、木栒子属(Cotoneasterserotina)、山楂属(Crataegus spp.)、黄瓜属(Cucumis spp.)、柏木属(Cupressus spp.)、粉背番桫椤(Cyathea dealbata)、榅桲(Cydonia oblonga)、柳杉(Cryptomeriajaponica)、香茅草(Cymbopogon spp.)、银蕨(Cynthea dealbata)、榅桲(Cydoniaoblonga)、货贝黄檀(Dalbergia monetaria)、大叶骨碎补(Davallia divaricata)、山蚂蟥属(Desmodium spp.)、粗糙蚌壳蕨(Dicksonia squarosa)、拢双黄茅(Dibeteropogonamplectens)、迪奥豆属(Dioclea spp)、扁豆属(Dolichos spp.)、豆科矛豆属(Dorycniumrectum)、金字塔稗(Echinochloa pyramidalis)、Ehraffia spp.、龙爪稷(Eleusinecoracana)、Eragrestis spp.、刺桐属(Erythrina spp.)桉树属(Eucalypfus spp.)、假乌木(Euclea schimperi)、绒毛状金茅(Eulalia vi/losa)、荞麦属(Pagopyrum spp.)、菲油果(Feijoa sellowlana)、草莓属(Fragaria spp.)、千斤拔属(Flemingia spp)、藤露兜属(Freycinetia banksli)、童氏老鹳草(Geranium thunbergii)、银杏(GinAgo biloba)、威地大豆(Glycine javanica)、南洋樱属(Gliricidia spp)、陆地棉(Gossypium hirsutum)、银桦属(Grevillea spp.)、小巴花(Guibourtia coleosperma)、岩黄芪属(Hedysarumspp.)、牛鞭草(Hemaffhia altissima)、黄茅(Heteropogon contoffus)、青稞(Hordeumvulgare)、泰国苞茅(Hyparrhenia rufa)、小连翘(Hypericum erectum)、(Hypeffheliadissolute)、Hypeffhelia dissolute、异花木蓝(Indigo incamata)、鸢尾属(Iris spp.)、常绿虎耳草(Leptarrhena pyrolifolia)、古月枝子属(Lespediza spp.)、生菜属(Lettucaspp.)、银合欢属(Leucaena leucocephala)、单罗得草(Loudetia simplex)、(Lotonusbainesli)、Lotonus bainesli、莲花属(Lotus spp.)、大结豆(Macrotyloma axillare)、苹果属(Malus spp.)、木薯(Manihot esculenta)、苜蓿(Medicago saliva)、水杉(Metasequoia glyptostroboides)、大蕉(Musa sapientum)、尼古丁属(Nicotianumspp.)、红豆草属(Onobrychis spp.)、鸟爪豆属(Ornithopus spp.)、稻属(Oryza spp.)、非洲盾柱木(Peltophorum africanum)、狼尾草属(Pennisetum spp.)、鳄梨(Perseagratissima)、矮牵牛属(Petunia spp.)、菜豆属(Phaseolus spp.)、加那利海枣(Phoenixcanariensis)、新西兰麻(Phormium cookianum)、石楠属(Photinia spp.)、白云杉(Piceaglauca)、松属(Pinus spp.)、豌豆(Pisum sativam)、桃柘罗汉松(Podocarpus totara)、Pogonarthria fleckii、Pogonaffhria squarrosa、杨树属(Populus spp.)、牧豆树(Prosopis cineraria)、花旗松(Pseudotsuga menziesii)、非洲老虎刺(Pterolobiumstellatum)、西洋梨(Pyrus communis)、栎属(Quercus spp.)、厚叶石斑木(Rhaphiolepsisumbellata)、香棕(Rhopalostylis sapida)、纳塔尔盐肤木(Rhus natalensis)、欧洲醋栗(Ribes grossularia)、醋栗属(Ribes spp.)、刺槐属(Robinia pseudoacacia)、蔷薇属(Rosa spp.)、黑莓属(Rubus spp.)、柳树属(Salix spp.)、红裂稃草(Schyzachyriumsanguineum)、金松(Sciadopitys vefficillata)、北美红杉(Sequoia sempervirens)、巨杉(Sequoiadendron giganteum)、高粱(Sorghum bicolor)、菠菜属(Spinacia spp.)、流苏状鼠尾粟(Sporobolus fimbriatus)、苦豆草(Stiburus alopecuroides)、矮柱花草(Stylosanthos humilis)、葫芦茶属(Tadehagi spp)、落羽杉(Taxodium distichum)、黄背草(Themeda triandra)、三叶草属(Trifolium spp.)、小麦属(Triticum spp.)、异叶铁杉(Tsuga heterophylla)、越橘属(Vaccinium spp.)、野豌豆属(Vicia spp.)、葡萄属(Vitisvinifera)、锥穗沃森花(Watsonia pyramidata)、马蹄莲(Zantedeschia aethiopica)、玉蜀黍(Zea mays)、苋菜(amaranth)、朝鲜蓟(artichoke)、芦笋(asparagus)、花椰菜(broccoli)、抱子甘蓝(Brussels sprouts)、甘蓝(cabbage)、芥花籽油(canola)、胡萝卜(carrot)、菜花(cauliflower)、芹菜(celery)、羽衣甘蓝(collard greens)、亚麻(flax)、羽衣甘蓝(kale)、兵豆(lentil)、油菜(oilseed rape)、秋葵(okra)、洋葱(onion)、土豆(potato)、水稻(rice)、大豆(soybean)、稻草(straw)、甜菜(sugar beet)、甘蔗(sugarcane)、向日葵(sunflower)、蕃茄(tomato)、南瓜茶(squash tea)、树(trees)。或者，藻类和其它非绿色植物可用于本公开一些实施方式的方法。
根据本公开的一些实施方式，所述植物是可食用的和/或无毒的植物，其可进行遗传修饰，从而导致核酸构建体的表达。
根据本公开的一些实施方式，所述植物是作物植物，例如但不限于水稻(rice)、玉米(maize)、小麦(wheat)、大麦(barley)、花生(peanut)、马铃薯(potato)、芝麻(sesame)、橄榄树(olive tree)、棕榈油(palm oil)、香蕉(banana)、大豆(soybean)、向日葵(sunflower)、芥花籽油(canola)、甘蔗(sugarcane)、苜蓿(alfalfa)、小米(millet)、豆科植物(leguminosae)(菜豆(bean)、豌豆(pea))、亚麻(flax)、羽扇豆(lupinus)、油菜籽(rapeseed)、烟草(tobacco)、番茄(tomato)、胡萝卜(carrot)、黄瓜(cucumber)、甜瓜(melon)、葡萄(grapes)、三叶草(while clover)、芹菜(celery)、姜(ginger)、辣根(horseradish)、杨树(poplar)和棉花(cotton)。
根据一个具体实施方式，所述植物是胡萝卜植物。
根据具体实施方式，所述植物选自由烟草(Tobacco)、拟南芥(Arabidopsis)、芦荟(Aloe Vera)、葡萄籽(grape seeds)、油棕(oil palm)、车前子(plantain)、松树(pine)、香蕉(banana)、大枣(date)、茄子(eggplant)、荷荷巴(jojoba)、菠萝、橡胶树、木薯、山药、甘薯和番茄所组成的组。
根据一个具体的实施方式，所述植物是烟草(Tobacco)植物。
根据一个具体的实施方式，所述烟草植物是烟草(Nicotiana tabacum)。
根据一个具体的实施方式，所述烟草植物是烟草(Nicotiana benthamiana)。
在一个实施方式中，烟草(Tobacco)细胞来自烟草(Tobacco)细胞系，例如但不限于烟草BY2细胞(Nicotiana tabacum L.cv Bright Yellow)细胞。
本公开一些实施方式的分离的植物细胞被引入了能够引入功能缺失性突变的试剂。
如本文所用，短语“功能缺失性突变(loss of function mutations)”是指基因(例如，DCL2、DCL4、RDR1、RDR2、RDR6)的DNA序列中的任何突变，其导致表达产物(即mRNA转录物和/或翻译的蛋白质)的表达水平和/或活性的下调。这种功能缺失性突变的非限制性示例包括错义突变(missense mutation)，即，用另一个氨基酸残基改变蛋白质中的氨基酸残基，并由此消除蛋白质的酶活性的突变；无义突变(nonsense mutation)，即，在蛋白质中引入终止密码子的突变，例如，导致缺乏酶活性的较短蛋白质的早期终止密码子；移码突变(frame-shift mutation)，即改变蛋白质阅读框架的突变，通常是核酸的缺失或插入，并可通过在阅读框架中引入终止密码子而导致早期终止(例如，截短的蛋白质，没有酶活性)，或导致较长的氨基酸序列(例如，通读蛋白质(readthrough protein))，其影响蛋白质的二级或三级结构，并导致非功能性蛋白质(non-functional protein)，无非突变多肽的酶活性；通读突变(readthrough mutation)，由于移码突变或修饰的终止密码子突变(即，当终止密码子突变为氨基酸密码子时)引起的，其酶活性被消除；启动子突变(promoter mutation)，即启动子序列中的突变，通常在基因转录起始位点的5’端，导致特定基因产物的下调；调节突变(regulatory mutation)，即在基因上游或下游区域中或基因内的突变，其影响基因产物的表达；缺失突变(deletion mutation)，即，即删除基因序列中编码核酸的突变，其可导致移码突变或整码突变(in-frame mutation)(在编码序列中，缺失一个或多个氨基酸密码子)；插入突变(insertion mutation)，即在基因序列中插入编码或非编码核酸的突变，其可导致一个或多个氨基酸密码子的移码突变或整码突变；倒位(inversion)，即导致反向编码或非编码序列的突变；剪接突变(splice mutation)，即导致异常剪接或不良剪接的突变；以及重复突变(duplication mutation)，即导致重复的编码或非编码序列的突变，其可以是整码的(in-frame)或者可以导致移码。
根据具体的实施方式，基因的功能缺失性突变可以包括基因的至少一个等位基因。
根据具体的实施方式，基因的功能缺失性突变包括基因的一个以上的等位基因。
根据具体实施方式，基因的功能缺失性突变包括基因的所有等位基因。
本文所用的术语“等位基因(allele)”是指基因位点(gene locus)的一种或多种替代形式中的任一种，所有这些等位基因与性状或特征相关。在二倍体细胞或生物体中，给定基因的两个等位基因占据一对同源染色体上的相应基因座(loci)。
由于DCL2、DCL4、RDR1和RDR2由烟草(Nicotinana)植物(例如烟草(Nicotianatabacum))中的两个不同基因编码，根据具体实施方式，功能缺失性突变包括该基因的所有四个等位基因。
由于RDR6由烟草(Nicotinana)植物(例如烟草(Nicotiana tabacum))中的三个不同基因编码，根据具体实施方式，功能缺失性突变包括该基因的所有六个等位基因。
在这种情况下，该试剂可以是靶向基因的不同等位基因的单一试剂，或者是分别靶向基因的至少一个等位基因的几种不同试剂。
因此，根据具体实施方式，功能缺失性突变在基因的所有等位基因共有的区域中。
根据其它具体实施方式，功能缺失性突变位于该基因的至少2个等位基因共有的区域中。
根据其它具体实施方式，功能缺失性突变位于基因的所有等位基因不共有的区域。
本文所用的共有区域(shared region)是指基因的野生型非突变等位基因中与该基因的另一种不同野生型非突变等位基因具有至少95％、至少96％、至少97％、至少98％、至少99％或100％序列同一性的区域。
根据具体实施方式，共有区域具有100％序列同一性。
可使用任何核酸序列比对算法如CLC、Vector NTI、Blast、ClustalW和MUSCLE来确定序列同一性。
根据具体实施方式，共有区域长度为至少10、至少15、至少20、至少25个核酸。
根据具体实施方式，DCL2中的功能缺失性突变位于对应于SEQ ID NO:74的核酸残基288-307和/或881-900和/或对应于SEQ ID NO:75的核酸残基288-307和/或881-900内。
根据具体实施方式，DCL2基因的所有等位基因共有的区域包含选自SEQ ID NO:1-2的序列。
由于该试剂可以包含DCL2基因的所有等位基因共有的区域的序列(参见图16)，根据具体的实施方式，该试剂包含DCL2 DNA靶向序列，该DCL2 DNA靶向序列包含选自SEQ IDNO:1-2的核酸序列。
根据具体实施方式，DCL4中的功能缺失性突变位于对应于SEQ ID NO:76的核酸残基967-986和/或1407-1426和/或对应于SEQ ID NO:77的核酸残基931-950和/或1371-1390内。
根据具体实施方式，DCL4基因的所有等位基因共有的区域包含选自SEQ ID NO:3-4的序列。
根据具体实施方式，所述试剂包含DCL4 DNA靶向序列，该DCL4DNA靶向序列包含选自SEQ ID NO:3-4的核酸序列。
根据具体实施方式，RDR1中的功能缺失性突变位于对应于SEQ ID NO:78的核酸残基916-937和/或962-984和/或对应于SEQ ID NO:79的核酸残基921-937和/或962-984内。
根据具体实施方式，RDR1基因的所有等位基因共有的区域包含选自SEQ ID NO:26-27的序列。
根据具体实施方式，该试剂包含RDR1 DNA靶向序列，该RDR1 DNA靶向序列包含选自SEQ ID NO:26-27的核酸序列。
根据具体实施方式，RDR2中的功能缺失性突变位于对应于SEQ ID NO：80的核酸残基575-553和/或589-612内；和/或对应于SEQ ID NO:81的核酸残基575-553和/或589-612。
根据具体实施方式，RDR2基因的所有等位基因共有的区域包含选自SEQ ID NO:28-29的序列。
根据具体实施方式，该试剂包含RDR2 DNA靶向序列，该RDR2 DNA靶向序列包含选自SEQ ID NO:28-29的核酸序列。
根据具体实施方式，RDR6中的功能缺失性突变位于对应于SEQ ID NO：82的核酸残基2767-2785和/或2820-2839、对应于SEQ ID NO：83的核酸残基49-67和/或102-121内；和/或对应于SEQ ID NO:84的核酸残基49-67和/或102-121。
根据具体实施方式，RDR6基因的所有等位基因共有的区域包含选自SEQ ID NO:30-31的序列。
根据具体实施方式，所述试剂包含RDR6 DNA靶向序列，所述RDR6DNA靶向序列包含选自SEQ ID NO:30-31的核酸序列。
如本文所用，短语“对应于序列号(corresponding to SEQ ID NO:)”旨在包括相对于编码所引用的酶的任何其他序列而言，该所引用的序列号的序列中关于其位置定义的核酸或其类似物。
向目标基因引入功能缺失性突变的方法是本领域熟知的[参见例如Menke D.，起源(Genesis)(2013)51:-618；Capecchi，科学(Science)(1989)244:1288-1292；Santiago等人，美国国家科学院院刊(Proc Natl Acad Sci USA)(2008)105:5809-5814；国际专利申请WO2014085593、WO2009071334和WO2011146121；美国专利US8771945、US8586526、US6774279，以及和美国专利申请US20030232410、US20050026157、US20060014264；其内容通过引用整体并入本文]，并包括靶向同源重组、位点特异性重组酶、PB转座酶(transposases)和通过工程核酸酶(engineered nucleases)进行的基因组编辑。用于向目标基因引入核酸改变的试剂可以设计成公开可获得的来源或从Transposagen、Addgene和Sangamo Biosciences商业获得。
以下描述了用于向目标基因引入功能缺失性突变的各种示例性方法，以及根据本公开的具体实施方式可以使用的用于实施这些方法的试剂。
根据具体的实施方式，所述试剂是基因组编辑试剂。
使用工程化内切核酸酶进行基因组编辑—该方法是指使用人工工程化核酸酶在基因组中所需位置切割和产生特异性双链断裂的反向遗传学方法，然后通过细胞内源过程如同源介导的双链DNA修复(homology directed repair，HDS)和非同源性末端接合(non-homologous end-joining，NHEJF)进行修复。NHEJF在双链断裂中直接连接DNA末端，而HDR利用同源供体序列作为模板在断裂点再生缺失的DNA序列。为了向基因组DNA中引入特定的核苷酸修饰，在HDR过程中必须存在含有所需序列的供体DNA修复模板。
不能使用传统的限制性内切核酸酶(restriction endonuclease)进行基因组编辑，因为大多数限制性内切酶将DNA上的几个碱基对识别为它们的靶标，并且这些序列通常会在基因组的许多位置上被发现，导致不限于所需位置的多次切割。为了克服这一挑战，并产生位点特异性单链或双链断裂，迄今为止已经发现并生物工程化了几种不同类型的核酸酶。这些包括例如巨核酸技术(meganucleases)、锌指核酸酶(ZFNs)、转录激活因子样效应物核酸酶(TALENs)和CRISPR/Cas系统。
巨核酸技术(Meganucleases)-巨核酸技术通常分为四个家族：LAGLIDADG家族、GIY-YIG家族、His-Cys盒家族(His-Cys box family)和HNH家族。这些家族的特征在于影响催化活性和识别序列的结构基序(structural motifs)。例如，LAGLIDADG家族的成员的特征在于具有保守的LAGLIDADG模体的一个或两个拷贝。这四个巨核酸技术家族在保守的结构元件方面，以及因此在DNA识别序列特异性和催化活性方面，彼此相距甚远。巨核酸技术常见于微生物物种中，具有含有很长识别序列(>14bp)的独特性质，因此使它们天然非常特异，可以在所需位置切割。
这可用于在基因组编辑中进行位点特异性双链断裂。本领域技术人员可以使用这些天然存在的巨核酸技术，然而这种天然存在的巨核酸技术的数量是有限的。为了克服这一挑战，已经使用诱变和高通量筛查方法来产生识别独特序列的巨核酸技术变体。例如，已经融合了各种巨核酸技术以产生识别新序列的杂合酶。
或者，可以改变与巨核酸技术的氨基酸相互作用的DNA，以设计序列特异性巨核酸技术(例如参见美国专利US8,021,867)。可以使用以下文献中描述的方法设计巨核酸技术：Certo,MT等人，自然方法(Nature Methods)(2012)9:073-975；美国专利US8,304,222；US8,021,867；US8,119,381；8,124,369；US8,129,134；US8,133,697；US8,143,015；US8,143,016；US8,148,098或US8,163,514，其各自的内容通过引用整体并入本文。或者，具有位点特异性切割特征的巨核酸技术可使用商业上可获得的技术(例如Precision Biosciences公司的定向核酸酶编辑器TM基因组编辑技术(Directed Nuclease EditorTMgenome editingtechnology))获得。
ZFNs和TALENs—两种不同类型的工程核酸酶、锌指核酸酶(ZFNs)和转录激活因子样效应物核酸酶(TALENs)，都被证明在产生靶向双链断裂方面是有效的(Christian等人，2010；Kim等人，1996；Li等人，2011；Mahfouz等人，2011；Miller等人，2010)。
基本上，ZFNs和TALENs限制性内切核酸酶技术利用非特异性DNA切割酶，其与特异性DNA结合结构域(分别是一系列锌指结构域或TALE重复)连接。通常选择其DNA识别位点和切割位点彼此独立的限制性酶。切割部分被分离，然后连接到DNA结合结构域，从而产生对所需序列具有非常高特异性的核酸内切酶。具有这种性质的示例性限制性酶是Fokl。此外，Fok1具有需要二聚化以具有核酸酶活性的优点，这意味着随着每个核酸酶伴侣(nucleasepartner)识别独特的DNA序列，特异性显著增加。为了增强这种效果，已经对Fok1核酸酶进行了工程改造，其只能作为异二聚体起作用，并且具有增加的催化活性。异二聚体功能核酸酶避免了不需要的同二聚体活性的可能性，因此增加了双链断裂的特异性。
因此，例如为了靶向特定位点，ZFNs和TALENs被构建为核酸酶对，该对中的每个成员被设计成在靶向位点结合相邻的序列。在细胞中瞬时表达时，核酸酶与它们的靶位点结合，FokI结构域异二聚体化以产生双链断裂。通过非同源性末端接合(non-homologousend-joining，NHEJ)途径修复这些双链断裂通常会导致小的缺失或小的序列插入。由于NHEJ进行的每次修复都是独特的，所以使用单个核酸酶对可以在靶位点产生具有一系列不同缺失的等位基因系列。
缺失的长度通常在几个碱基对到几百个碱基对的范围内，但是通过同时使用两对核酸酶，已经在细胞培养物中成功产生了更大的缺失(Carlson等人，2012；Lee等人，2010年)。此外，当与靶区域具有同源性的DNA片段与核酸酶对一起引入时，双链断裂可通过同源性指导的修复来修复，以产生特异性修饰(Li等人，2011；Miller等人，2010；Urnov等人，2005)。
尽管ZFNs和TALENs的核酸酶部分具有相似的性质，但这些工程核酸酶之间的差异在于它们的DNA识别肽。ZFNs依赖Cys2-His2锌指，TALENs依赖TALEs。这两种识别肽结构域的DNA都具有这样的特征，即它们在它们的蛋白质中以组合的形式天然存在。Cys2-His2锌指通常在间隔3bp的重复中发现，并在各种核酸相互作用蛋白质中以不同的组合发现。另一方面，TALEs在氨基酸和识别的核苷酸对之间具有一对一识别比的重复中被发现。因为锌指和TALEs都以重复的模式出现，所以可以尝试不同的组合来产生各种各样的序列特异性。用于制备位点特异性锌指内切酶的方法包括，例如，模块化组装(其中与三联体序列相关的锌指连接成一排以覆盖所需序列)、OPEN(在细菌系统中，肽结构域相对于三联体核苷酸的低严格性选择，随后肽组合相对于最终靶的高严格性选择)，以及锌指文库(zinc fingerlibraries)的细菌单杂交筛查等。其中。ZFNs也可以从例如Sangamo BiosciencesTM(Richmond,CA)设计和商购获得。
在以下文献中描述了用于设计和获得滑石的方法：例如Reyon等人，自然生物技术(Nature Biotechnology)2012年5月，30(5):460-5；Miller等人，自然生物技术(NatBiotechnol.)(2011)29:143-148；Cermak等人，核酸研究(Nucleic Acids Research)(2011)39(12):E82，以及Zhang等人，自然生物技术(Nature Biotechnology)(2011)29(2):149-53。最近开发的名为Mojo Hand的基于网络的程序由Mayo Clinic引入，用于设计基因组编辑应用的TAL和talen结构(可通过www.talendesign.org访问)。也可从例如SangamoBiosciencesTM(里奇蒙港(Richmond,CA))设计和商购获得。
CRISPR-Cas系统(在本文中也称为“CRISPR”)—许多细菌和古细菌(archea)包含可以降解入侵噬菌体和质粒的核酸的内源性RNA-基适应性免疫系统(endogenous RNA-based adaptive immune system)。这些系统由产生RNA成分的簇状规则间隔短回文重复(short palindromic repeat，CRISPR)核苷酸序列和编码蛋白质成分的CRISPR相关(CRISPR associated，Cas)基因组成。CRISPR RNAs(crRNAs)包含与特定病毒和质粒的DNA同源的短序列(short stretches)，并作为指导Cas核酸酶降解相应病原体的互补核酸的向导。对酿脓链球菌(Streptococcus pyogenes)II型CRISPR/Cas系统的研究已经表明，三种成分形成RNA/蛋白质复合物，并且一起足以用于序列特异性核酸酶活性：Cas9核酸酶、含有与靶序列同源的20个碱基对的crRNA，和反式激活crRNA(trans-activating crRNA，tracrRNA)(Jinek等人，科学(Science)(2012)337:816-821)。进一步证明了由crRNA和tracrRNA之间的融合组成的合成的嵌合向导RNA(guide RNA，gRNA)可以指导Cas9在体外切割与crRNA互补的DNA靶。还证明了与合成gRNAs结合的Cas9的瞬时表达可用于在各种不同物种中产生靶向双链制动器(Cho等人，2013；Cong等人，2013；DiCarlo等人，2013；Hwang等人，2013a,b；Jinek等人，2013；Mali等人，2013)。
用于基因组编辑的CRIPSR/Cas系统包含两个不同的组分：gRNA和内切核酸酶(例如Cas9)。
gRNA/Cas复合体通过gRNA序列和互补基因组DNA之间的碱基配对被募集到靶序列上。为了成功结合Cas9，基因组靶序列还必须包含紧跟在靶序列之后的正确的前间隔序列邻近基序(Protospacer Adjacent Motif，PAM)序列。gRNA/Cas9复合物的结合将Cas9定位于(localizes)基因组靶序列，使得Cas9可以切割DNA的两条链，引起双链断裂。正如ZFNs和TALENs一样，由CRISPR/Cas产生的双链断裂可以经历同源重组或NHEJ，并且在DNA修复过程中容易受到特定序列修饰的影响。
Cas9核酸酶具有两个功能结构域(functional domains)：RuvC和HNH，各自切割不同的DNA链。当这两个结构域都有活性时，Cas9在基因组DNA中引起双链断裂。
CRISPR/Cas的一个显著优点是该系统的高效率以及容易产生合成gRNAs的能力。这产生了一种系统，该系统可以容易地被修饰，以靶向不同基因组位点的修饰和/或靶向相同位点的不同修饰。此外，已经建立了能够同时靶向多个基因的方案。大多数携带突变的细胞在靶基因中存在双等位基因突变。
然而，在gRNA序列和基因组DNA靶序列之间的碱基配对相互作用中明显的灵活性允许通过内切核酸酶(例如Cas9)切割与靶序列的不完全匹配。
含有单一无活性催化结构域RuvC-或HNH-的Cas9酶的修饰形式被称为“切口酶(nickases)”。由于只有一个活性核酸酶结构域，Cas9切口酶仅切割靶DNA的一条链，产生单链断裂或“切口(nick)”。单链断裂或切口通常通过HDR途径快速修复，使用完整的互补DNA链作为模板。然而，在通常被称为“双缺口(double nick)”CRISPR系统中，由Cas9切口酶引入的两个近端相对的链缺口被视为双链断裂。双切口可以由NHEJ或HDR修复，这取决于对基因靶的预期效果。因此，如果特异性和减少脱靶效应是至关重要的，那么使用Cas9切口酶通过设计靶序列非常接近且在基因组DNA的相对链上的两种gRNA来产生双切口，将减少脱靶效应，因为任一gRNA单独将产生不会改变基因组DNA的切口。
为了在特定位点切割DNA，Cas9蛋白需要存在gRNA和前间隔序列邻近基序(PAM)，其紧跟在靶多核苷酸基因序列中的gRNA靶序列之后。PAM位于gRNA靶序列的3’末端，但不是gRNA的一部分。不同的Cas蛋白质需要不同的PAM。因此，gRNA对特定多核苷酸gRNA靶序列的选择通常基于所用的重组Cas蛋白。PAM序列的非限制性示例包括5-NRG-3’，其中R是A或G、NNGRR(SEQ ID NO:85)，“NGG”序列、“NAG”、NNNNGATT(SEQ ID NO:86)和NNNGNNN(SEQ IDNO:87)，其中“N”可以是任何核苷酸(例如T、G、A)。根据具体的实施方式，PAM序列选自TGG、GGG和AGG。
gRNA包含“gRNA向导序列”或“gRNA靶序列”，其对应于靶多核苷酸基因序列上的靶序列，随后是PAM序列。
尽管gRNA向导序列和靶基因上的DNA序列之间的完美匹配是优选的，但是gRNA向导序列和目标基因序列上的靶序列之间的错配也是允许的，只要它仍然允许gRNA与靶基因上的gRNA靶多核苷酸序列的互补链杂交。与gRNA靶序列的相应部分完美匹配的gRNA中8至12个连续核苷酸的种子序列对于正确识别靶序列是优选的。向导序列的剩余部分可以包含一个或多个错配。一般来说，gRNA活性与错配数量呈负相关。根据具体实施方式，本公开的gRNA与相应的gRNA靶基因序列(少于PAM)包含7个错配、6个错配、5个错配、4个错配、3个错配、2个错配或更少，甚至没有错配。根据具体实施方式，gRNA核酸序列与目标基因中的gRNA靶多核苷酸序列至少90％、至少91％、至少92％、至少93％、至少94％、至少95％、至少96％、至少97％、至少98％或至少99％相同。当然，gRNA向导序列中核苷酸的数量越少，容许的错配数量就越少。结合亲和力被认为取决于匹配的gRNADNA组合的总和。
可以在靶核酸序列中选择任何gRNA向导序列，只要它允许在合适的位置引入本公开的膜片(patch)/供体序列。因此，本公开的gRNA向导序列或靶序列可以位于基因的编码区或非编码区(即内含子或外显子)。
在一个实施方式中，gRNA是sgRNA。
如本文所用，术语“sgRNA”是指与CRISPR相关系统(Cas)结合使用的单一向导RNA。sgRNA是crRNA和tracrRNA的融合体，含有与所需靶位点互补的核苷酸序列。Jinek等人，“适应性细菌免疫中的可编程双RNA向导DNA核酸内切酶(A programmable dual-RNA-guidedDNA endonuclease in adaptive bacterial immunity)”，科学(Science)337(6096):816-821(2012),sgRNA与靶位点的Watson-Crick配对允许R-环形成，其与功能性PAM结合允许DNA切割，或者在核酸酶缺陷的情况下，Cas9允许与该基因座的DNA结合。
有许多公开可用的工具来帮助选择和/或设计靶序列以及不同物种中不同基因的生物信息学确定的独特gRNAs列表，如冯张实验室的靶探测器(Feng Zhang lab's TargetFinder)、迈克尔·布特罗斯实验室(Michael Boutros lab)的靶探测器(E-CRISP)、RGEN工具：Cas-OFFinder、CasFinder：用于鉴定基因组中的特定Cas9靶的灵活算法和CRISPR最优靶探测器。
可用于本公开的gRNA的非限制性示例包括以下实施例部分中描述的那些。
因此，例如，靶DCL2的gRNA序列可以包含选自由SEQ ID NO:1-2所组成的组的核酸序列，靶DCL4的gRNA序列可以包含选自由SEQ ID NO:3-4所组成的组的核酸序列，靶RDR1的gRNA序列可以包含选自由SEQ ID NO:26-27所组成的组的核酸序列，靶RDR2的gRNA序列可包含选自由SEQ ID NO:28-29所组成的组的核酸序列，靶RDR6的gRNA序列可包含选自由SEQID NO:30-31所组成的组的核酸序列。
为了使用CRISPR系统，gRNA和CAS核酸内切酶(例如Cas9)都应在靶细胞中表达。插入载体在单个质粒上可以包含两个盒(cassettes)，或者由两个单独的质粒表达的盒。此外，插入载体可以包含编码选择性标记物、内部核糖体进入位点(internal ribosomeentry site，IRES)等的核酸序列。CRISPR质粒是商业上可获得的，例如来自Addgene的px330质粒(马萨诸塞州剑桥市悉尼街75号550A套房，邮编02139(75Sidney St,Suite550A·Cambridge,MA 02139))或来自ATCC的pBIN19载体(目录号(catalog number)37327)。至少在如下文献中也公开了簇状规则间隔短回文重复序列(CRISPR)-相关(Cas)-向导RNA技术和Cas核酸内切酶用于修饰植物基因组的用途：Svitashev等人，2015,植物生理学(Plant Physiology),169(2):931-945；Kumar和Jain，2015，实验植物学杂志(JExpBot)66:47-57；以及在美国专利申请公开US20150082478，具体地，其通过引用整体并入本文。可用于用gRNA实现DNA编辑的CAS内切核酸酶包括但不限于Cas9、CasX、Cpf1(Zetsche等人，2015，细胞(Cell.)163(3):759-71)、C2C1、C2C2和C2C3(Shmakov等人，分子细胞(MolCell.)2015年11月5日；60(3):385-97)。
T-GEE系统(TargetGene公司的基因组编辑引擎(Genome Editing Engine))—一种含有多肽部分和特异性赋予核酸(specificity conferring nucleic acid，SCNA)的可编程核蛋白分子复合物，其在靶细胞中在体内组装，并能够与预定的靶核酸序列相互作用。可编程的核蛋白分子复合物能够特异性修饰和/或编辑靶核酸序列中的靶位点和/或修饰靶核酸序列的功能。核蛋白组合物包含(a)编码嵌合多肽的多核苷酸分子，其包含(i)能够修饰靶位点的功能域，和(ii)能够与特异性赋予核酸相互作用的连接域；以及(b)赋予特异性的核酸(specificity conferring nucleic acid，SCNA)，其包含(i)与靶位点侧翼的靶核酸的区域互补的核苷酸序列，和(ii)能够特异性连接所述多肽的连接结构域的识别区。该组合物能够通过赋予特异性的核酸和靶核酸的碱基配对，以分子复合物对靶核酸的高特异性和结合能力，精确、可靠和成本有效地修饰预定的核酸序列靶。该组合物基因毒性较低，组装中模块化，利用单一平台而无需定制，可在专门的核心设施之外独立使用，并具有较短的开发时间框架和降低的成本。
“打了就跑(Hit and run)”和“进-出(in-out)”涉及两步重组程序。在第一步中，使用含有双阳性(positive)/阴性(negative)可选择标记盒的插入型载体引入所需的序列改变。插入载体含有与靶基因座同源的单个连续区域，并被修饰以携带目标突变。用限制性内切酶在同源区域内的一个位点将该靶向构建体线性化，电穿孔进入细胞，并进行阳性选择以分离同源重组体。这些同源重组体包含一个局部复制(local duplication)，该局部复制被包括选择盒在内的插入载体序列分开。在第二步中，对靶向克隆进行阴性选择，以鉴定通过重复序列之间的染色体内重组而失去选择盒的细胞。局部重组事件(localrecombination event)消除了重复，根据重组位点，等位基因保留引入的突变或回复到野生型。最终结果是引入所需的修饰而不保留任何外源序列。
“双重置换(double-replacement)”或“标记和置换法(tag and exchange)”策略—涉及类似于“打了就跑”方法的两步选择程序，但需要使用两种不同的靶向构建体。在第一步中，使用具有3’和5’同源臂(homology arms)的标准靶向载体在将要引入突变的位置附近插入双重阳性/阴性可选择盒。在电穿孔和阳性选择后，鉴定同源靶向克隆。接下来，将含有与所需突变同源的区域的第二靶向载体电穿孔到靶向克隆中，并应用阴性选择除去选择盒并引入突变。最终的等位基因含有所需突变，同时消除了不需要的外源序列。
位点特异性重组酶(Site-Specific Recombinases)—来自P1噬菌体的Cre重组酶和来自酵母酿酒酵母(Saccharomyces cerevisiae)的Flp重组酶是位点特异性DNA重组酶，其各自识别独特的34个碱基对DNA序列(分别称为“Lox”和“FRT”)和侧翼有Lox位点或FRT位点的序列，当分别表达Cre或Flp重组酶时，可以通过位点特异性重组容易地除去。分别是组合酶。例如，Lox序列由不对称的8个碱基对的间隔区组成，两侧是13个碱基对的反向重复序列。Cre通过结合13个碱基对的反向重复序列并在间隔区内催化链切割和重新连接，重组34个碱基对的lox DNA序列。Cre在间隔区产生的交错DNA切割被6个碱基对分开，产生一个重叠区，该重叠区作为同源传感器，以确保只有具有相同重叠区的重组位点才能重组。
基本上，位点特异性重组酶系统提供了同源重组后除去选择盒的方法。该系统还允许产生条件性改变的等位基因，所述等位基因可以以时间或组织特异性方式失活或激活。值得注意的是，Cre和Flp重组酶留下34个碱基对的Lox或FRT“疤痕(scar)”。保留的Lox或FRT位点通常留在修饰基因座的内含子或3'UTR中，目前的证据表明这些位点通常不会显著干扰基因功能。
因此，Cre/Lox和Flp/FRT重组涉及引入具有3’和5’同源臂的靶向载体，其有目标突变、两个Lox或FRT序列，以及通常是置于两个Lox或FRT序列之间的可选择盒。应用阳性选择并鉴定含有靶向突变的同源重组体。Cre或Flp的瞬时表达结合阴性选择结合导致选择盒的切除，并选择盒已经丢失的细胞。最终靶向的等位基因含有外源序列的Lox或FRT疤痕。
可以通过本领域已知的任何方法将能够将引入功能缺失性突变的试剂引入植物细胞。
根据具体实施方式，向细胞中引入包含编码该试剂的核酸序列的核酸构建体。
如本文所用，术语“核酸序列(nucleic acid sequence)”或“多核苷酸(polynucleotide)”是指以RNA序列、互补多核苷酸序列(complementary polynucleotidesequence，cDNA)、基因组多核苷酸序列和/或复合多核苷酸序列(例如，上述序列的组合)的形式被分离和提供的单链或双链核酸序列。
可使用本领域技术人员熟知的重组DNA技术构建可用于根据本公开的一些实施方式的方法的构建体。可以将基因构建体插入到载体中，所述载体可以是市售的，适于转化到植物中，并且适于在转化的细胞中表达目标核酸序列。遗传构建体可以是表达载体，其中所述核酸序列与一个或多个允许在植物细胞中以组成型或诱导型方式表达的调控序列(regulatory sequences)可操作地连接。
在本公开一些实施方式的特定实施方式中，调控序列是植物可表达的启动子。
如本文所用，短语“植物可表达的(plant-expressible)”是指启动子序列，包括添加到其中或包含在其中的任何额外的调控元件(regulatory elements)，其至少能够在植物细胞，优选单子叶或双子叶植物细胞中诱导、赋予(conferring)、活化或增强表达。
这包括植物来源的任何启动子，也包括能够在植物细胞中指导转录的非植物来源的任何启动子，即，病毒或细菌来源的某些启动子，如CaMV35S(Harpster等人，(1988)分子遗传学和普通遗传学(Mol Gen Genet.)212(1):182-90)、III型RNA聚合酶III启动子(U6)、地下三叶草病毒启动子No 4或No 7(WO9606932)，或T-DNA基因启动子，但也包括组织特异性或器官特异性启动子，包括但不限于：种子特异性启动子(例如，WO89/03887)、器官-原基(organ-primordia)特异性启动子(An等人，(1996)植物细胞(Plant Cell)8(1):15-30)、茎特异性启动子(Keller等人，(1988)欧洲分子生物学学会期刊(EMBO J.)7(12):3625-3633)、叶特异性启动子(Hudspeth等人，(1989)植物分子生物学(Plant Mol Biol.)12:579-589)、叶肉(mesophyl)特异性启动子、根特异性启动子(Keller等人，(1989)基因与发育(Genes Dev.)3:1639-1646)、块茎(tuber)特异性启动子(Keil等人，(1989)欧洲分子生物学学会期刊(EMBO J.)8(5):1323-1330)、维管组织(vascular tissue)特异性启动子(Peleman等人，(1989)基因(Gene)84:359-369)、雄蕊选择性启动子(WO 89/10396、WO 92/13956)、开裂区(dehiscence zone)特异性启动子(WO97/13865)等。
根据具体实施方式，启动子是组成型启动子(constitutive promotor)。
根据其它具体实施方式，启动子是诱导型启动子(inducible promotor)。
本公开一些实施方式的核酸序列可以针对植物表达进行优化。这种序列修饰的示例包括但不限于改变G/C含量，以更接近通常在目标植物物种中发现的G/C含量，以及去除通常称为密码子优化的在植物物种中非典型发现的密码子。
短语“密码子优化(codon optimization)”是指选择适合的DNA核苷酸用于结构基因或其片段中，该结构基因或其片段接近目标植物细胞中的密码子使用(codon usage)。因此，优化的基因或核酸序列是指这样的基因，其中天然或天然存在的基因的核苷酸序列已经被修饰，以便在植物细胞内利用统计学上优选的或统计学上有利的密码子。通常在DNA水平上检查核苷酸序列，并使用任何合适的方法，例如，如Sardana等人(1996，植物细胞报道(Plant Cell Reports)15:677-681)所述的方法，确定为在植物物种中表达而优化的编码区。在该方法中，密码子使用的标准偏差(密码子使用偏差的量度)可以通过首先发现天然基因的每个密码子相对于高度表达的植物基因的使用的平方比例偏差，然后计算平均平方偏差来计算。所用的公式是：1SDCU＝n＝1N[(Xn-Yn)/Yn]2/N，其中Xn是指高度表达的植物基因中密码子n的使用频率，其中Yn是指目标基因中密码子n的使用频率，N是指目标基因中密码子的总数。使用Murray等人(1989,核酸研究(Nuc Acids Res.)17:477-498)的数据编制了双子叶植物高表达基因的密码子使用表。
根据特定植物细胞类型的优选密码子使用来优化核酸序列的一种方法是基于直接使用密码子优化表(codon optimization tables)，而不进行任何额外的统计计算，例如通过日本NIAS(国家农业生物科学研究所(National Institute of AgrobiologicalSciences))DNA库(bank)在线提供的密码子优化表(www.kazusa.or.jp/codon/)。密码子使用数据库(Codon Usage Database)包含许多不同物种的密码子使用表，每个密码子使用表是基于基因库(Genbank)中存在的数据统计确定的。
通过使用上表来确定特定物种(例如，水稻)中每种氨基酸的最优选或最受青睐的密码子，编码目标蛋白质的天然存在的核苷酸序列可以针对该特定植物物种进行密码子优化。这是通过用在统计学上更有利的氨基酸的相应密码子替换在特定物种基因组中可能具有低统计发生率的密码子来实现的。然而，可以选择一个或多个不太受欢迎的密码子来删除现有的限制位点，以在潜在有用的连接处(5’和3’末端添加信号肽或终止盒，内部位点可用于切割和剪接片段以产生正确的全长序列)产生新的限制位点，或消除可能对mRNA稳定性或表达产生负面影响的核苷酸序列。
在任何修饰之前，天然存在的编码核苷酸序列可能已经含有许多密码子，这些密码子对应于特定植物物种中的统计学上有利的密码子。因此，天然核苷酸序列的密码子优化可以包括确定天然核苷酸序列中的哪些密码子对于特定植物不是统计学上有利的，并根据特定植物的密码子使用表修饰这些密码子以产生密码子优化的衍生物。修饰的核苷酸序列可以完全或部分针对植物密码子使用进行优化，条件是由修饰的核苷酸序列编码的蛋白质以高于相应天然存在或天然基因编码的蛋白质的水平产生。在例如PCT专利申请93/07278中描述了通过改变密码子使用来构建合成基因。
本公开一些实施方式的核酸构建体可以进一步包括另外的多核苷酸序列，其允许例如从单个mRNA(如内部核糖体进入位点(internal ribosome entry site，IRES))翻译几种蛋白质和用于基因组整合的序列。
可以用一些实施方式的核酸构建体稳定地或瞬时地转化植物细胞。在稳定转化中，一些实施方式的核酸分子整合到植物基因组中，因此它代表稳定的遗传性状。在瞬时转化(transient transformation)中，核酸分子由转化的细胞表达，但它不整合到基因组中，因此它代表瞬时性状。
根据具体的实施方式，转化步骤包括稳定转化。
有多种将外源基因引入单子叶植物和双子叶植物的方法(Potrykus,I.，植物生理学报(Annu.Rev.Plant.Physiol.)，植物分子生物学(Plant.Mol.Biol.)(1991)42:205-225；Shimamoto等人，自然(Nature)(1989)338:274-276)。
引起外源DNA稳定整合到植物基因组DNA中的主要方法包括两种主要方法：
(i)农杆菌介导的基因转移(Agrobacterium-mediated gene transfer)：Klee等人(1987)植物生理学报(Annu.Rev.Plant Physiol.)38:467-486；Klee和Rogers，植物细胞培养和体细胞遗传学(Cell Culture and Somatic Cell Genetics of Plants)第6卷，植物核基因的分子生物学(Molecular Biology of Plant Nuclear Genes)，Schell,J.和Vasil,L.K.编辑，学术出版社(Academic Publishers)，加利福尼亚州圣迭戈(San Diego,Calif.)(1989)第2-25页；Gatenby，植物生物技术(Plant Biotechnology)，Kung,S.和Arntzen,C.J.编辑，北海出版社(Butterworth Publishers)，波士顿麻省(Boston,Mass.)(1989)第93-112页。
(ii)DNA直接摄取法(direct DNA uptake)：Paszkowski等人，植物细胞培养和体细胞遗传学(Cell Culture and Somatic Cell Genetics of Plants)第6卷，植物核基因的分子生物学(Molecular Biology of Plant Nuclear Genes)，Schell,J.和Vasil,L.K.编辑，学术出版社(Academic Publishers)(1989)p.52-68；包括将DNA直接吸收到原生质体中的方法，Toriyama,K.等人(1988)生物/技术(Bio/Technology)6:1072-1074；植物细胞短暂电击诱导的DNA摄取：Zhang等人，植物细胞报告(Plant Cell Rep.)(1988)7:379-384；Fromm等人，自然(Nature)(1986)319:791-793；通过粒子轰击将DNA注入到植物细胞或组织中；Klein等人，生物/技术(Bio/Technology)(1988)6:559-563；McCabe等人，生物/技术(Bio/Technology)(1988)6:923-926；Sanford，植物生理学(Physiol.Plant.)(1990)79:206-209；通过使用微量移液管系统：Neuhaus等人，理论与应用遗传学(Theor.Appl.Genet.)(1987)75:30-36；Neuhaus和Spangenberg,植物生理学(Physiol.Plant.)(1990)79:213-217；细胞培养物、胚胎或愈伤组织的玻璃纤维或碳化硅晶须转化，美国专利US5,464,765，或通过DNA与萌发的花粉直接温育，DeWet等人，在胚珠组织的实验操作中，Chapman,G.P.和Mantell,S.H.和Daniels,W.London编辑，(1985)第197-209页；以及Ohta，美国国家科学研究院学报(Proc.Natl.Acad.Sci.USA)(1986)83:715-719。
农杆菌系统包括使用含有整合到植物基因组DNA中的确定DNA片段的质粒载体。植物细胞的接种方法根据植物物种和土壤杆菌递送系统而变化。一种广泛使用的方法是叶盘法(leaf disc procedure)，其可以用任何组织外植体进行，该外植体为整个植物分化的起始提供了良好的来源。Horsch等人，植物分子生物学手册(Plant Molecular BiologyManual A5，鲁维尔学术出版社(Kluwer Academic Publishers)多德雷赫特(1988)第1-9页)。一种补充的方法是将农杆菌递送系统与真空渗透结合使用。农杆菌系统在转基因双子叶植物的产生中特别可行。
有多种将DNA直接转移到植物细胞中的方法。在电穿孔中，原生质体短暂地暴露于强电场。在显微注射中，使用非常小的微量移液管将DNA机械地直接注射到细胞中。在微粒轰击(microparticle bombardment)中，DNA被吸附在诸如硫酸镁晶体或钨颗粒的微粒上，并且微粒被物理加速进入细胞或植物组织。
尽管稳定转化目前是优选的，但是本公开的一些实施方式也设想了植物细胞的瞬时转化。
瞬时转化可以通过上述任何直接DNA转移方法或通过使用修饰的植物病毒的病毒感染来实现。
已显示可用于转化植物宿主的病毒包括CaMV、TMV和BV。使用植物病毒转化植物细胞描述于如下文献中：美国专利US4,855,237(BGV)、EP-A 67,553(TMV)、日本公开申请JP63-14693(TMV)、EPA 194,809(BV)、EPA 278,667(BV)；以及Gluzman,Y.等人，分子生物学通信(Communications in Molecular Biology)：病毒载体(Viral Vectors)，冷泉港实验室，纽约，第172-189页(1988)。WO87/06261中描述了用于在包括植物在内的许多宿主中表达外源DNA的假病毒颗粒。
用于在植物中引入和表达非病毒外源核酸序列的植物RNA病毒的构建由上述参考文献以及如下文献所证实：Dawson,W.O.等人，病毒学(Virology)(1989)172:285-292；Takamatsu等人，欧洲分子生物学学会期刊(EMBO J.)(1987)6:307-311；French等人，科学(Science)(1986)231:1294-1297；以及Takamatsu等人，欧州生物化学会通讯(FEBSLetters)(1990)269:73-76。
当病毒是DNA病毒时，可以对病毒本身进行适当的修饰。或者，可以首先将病毒克隆到细菌质粒中，以便于用外源DNA构建所需的病毒载体。然后可以从质粒上切除病毒。如果病毒是DNA病毒，则细菌复制起点可以附着于病毒DNA上，然后病毒DNA被细菌复制。该DNA的转录和翻译将产生包囊病毒DNA的外壳蛋白(coat protein)。如果病毒是RNA病毒，通常将病毒克隆为cDNA并插入质粒中。然后将质粒用于制备所有构建体。然后通过转录质粒的病毒序列和翻译病毒基因来产生包裹病毒RNA的外壳蛋白来产生RNA病毒。
用于在植物中引入和表达非病毒外源性核酸序列的植物RNA病毒的构建，如本公开一些实施方式的构建中所包括的那些，由以上参考文献以及美国专利US5,316,931中所证明。
在一个实施方式中，提供了植物病毒核酸，其中天然外壳蛋白编码序列已经从病毒核酸中缺失，并插入了非天然植物病毒外壳蛋白编码序列和非天然启动子，优选非天然外壳蛋白编码序列的亚基因组启动子，其能够在植物细胞宿主中表达，包装重组植物病毒核酸，并确保宿主被重组植物病毒核酸全身性感染。或者，外壳蛋白基因可以通过插入非天然核酸序列而失活，从而产生蛋白质。重组植物病毒核酸可以含有一个或多个额外的非天然亚基因组启动子。每个非天然亚基因组启动子能够在植物宿主细胞中转录或表达相邻的基因或核酸序列，并且不能彼此重组，也不能与天然亚基因组启动子重组。如果包括一个以上的核酸序列，可以将非天然(外源)核酸序列插入天然植物病毒亚基因组启动子或天然和非天然植物病毒亚基因组启动子附近。非天然核酸序列在亚基因组启动子的控制下在宿主植物细胞中转录或表达，以产生所需产物。
在第二实施方式中，如在第一个实施方式中一样提供了重组植物病毒核酸，不同之处在于天然外壳蛋白编码序列与非天然外壳蛋白亚基因组启动子之一相邻而不是与非天然外壳蛋白编码序列相邻。
在第三实施方式中，提供了重组植物病毒核酸，其中天然外壳蛋白基因与其亚基因组启动子相邻，并且一个或多个非天然亚基因组启动子已经插入到病毒核酸中。插入的非天然亚基因组启动子能够在植物宿主细胞中转录或表达相邻基因，并且不能彼此重组，也不能与天然亚基因组启动子重组。非天然核酸序列可以插入到非天然亚基因组植物病毒启动子附近，使得所述序列在亚基因组启动子的控制下在宿主植物中转录或表达，以产生所需的产物。
在第四实施方式中，除了天然外壳蛋白编码序列被非天然外壳蛋白编码序列替代之外，如第三实施方式中一样提供了重组植物病毒核酸。
病毒载体被重组植物病毒核酸编码的外壳蛋白包裹，以产生重组植物病毒。重组植物病毒核酸或重组植物病毒用于感染合适的宿主植物细胞。重组植物病毒核酸能够在宿主细胞中复制，在细胞培养物中全身性扩散，并在宿主细胞中转录或表达外源基因(分离的核酸)，以产生所需的蛋白质。
除上述之外，本公开一些实施方式的核酸分子也可被引入叶绿体基因组中，从而使叶绿体表达成为可能。
将外源核酸序列引入叶绿体基因组的技术是已知的。该技术包括以下过程。首先，对植物细胞进行化学处理，使每个细胞的叶绿体数量减少到大约一个。然后，通过粒子轰击将外源核酸引入细胞，目的是将至少一种外源核酸分子引入叶绿体。选择外源核酸，使其可通过同源重组整合到叶绿体的基因组中，该同源重组容易受到叶绿体固有的酶的影响。为此，除了目标基因之外，外源核酸还包括至少一个来自叶绿体基因组的核酸序列。此外，外源核酸包括选择标记物，其通过顺序选择(sequential selection)程序来确定在这种选择之后叶绿体基因组的所有或基本上所有拷贝将包括外源核酸。关于该技术的进一步细节可在如下文献中找到：美国专利US4,945,050和US5,693,507，其通过引用并入本文。因此，多肽可以由叶绿体的蛋白质表达系统产生，并整合到叶绿体的内膜中。
在转化步骤之后，植物细胞可以培养至少6小时、至少12小时、至少1天、至少2天、至少1周、至少2周或至少3周、至少1个月、至少2个月、至少3个月、至少4个月、至少6个月，每种可能性代表本公开的单独实施方式。
可以在阳性选择培养基中培养细胞，以鉴定已经成功转化的细胞。
如本文所用，短语“阳性选择培养基(positive selective medium)”是指选择含有阳性选择标记基因的细胞的培养基或生长条件。当暴露于通常对不含阳性选择标记基因的细胞的存活有害的试剂或条件时，转化的细胞存活和/或生长。
也可进行测序分析以鉴定已成功转化的细胞。
如果构建体编码能够将功能缺失性突变引入植物细胞的试剂(例如，沉默试剂)，则可以进行测序分析以确认突变的存在。
如果构建体编码能够将功能缺失性突变引入植物细胞的试剂(例如，沉默试剂)，则可以进行另外的分析以证实目标基因(例如，DCL2、DCL4、RDR1、RDR1、RDR6)的表达和/或活性的下调。确定表达和/或活性的下调的方法是本领域熟知的，包括RT-PCR、ELISA、蛋白质印迹(Western blot)、IP等。
根据具体实施方式，功能缺失性突变消除了基因表达产物的表达和/或活性。
因此，根据具体实施方式，如通过RT-PCR或Western印迹所确定的，功能缺失性突变消除了DCL2、DCL4、RDR1、RDR2和/或RDR6的表达。
根据具体实施方式，功能缺失性突变消除了DCL2的表达和/或活性，如通过转基因在植物细胞中表达后转基因特异性21-nt SiRNA在植物细胞中没有表达来确定。
根据具体的实施方式，功能突变的丧失消除了DCL4的表达和/或活性，如通过转基因在植物细胞中表达后转基因特异性22-nt siRNA在植物细胞中没有表达来确定。
确定转基因特异性21-nt和/或22-nt siRNA的方法在本领域中是熟知的，并且也在随后的实施例部分中有详细描述。
如果构建体编码目标表达产物，而不是如下文进一步描述的能够将功能突变的丧失引入植物细胞(例如，目标重组蛋白)的试剂，则可以进行另外的分析以证实目标表达产物的表达和/或活性。确定表达和/或活性的方法是本领域众所熟知的，包括RT-PCR、ELISA、蛋白质印迹、IP等。
本公开的具体实施方式还涉及通过本文公开的方法制备的植物细胞。
因此，根据本公开的一个方面，提供了一种可通过该方法获得的植物细胞。
根据本公开的另外的或替代的方面，提供了一种悬浮的分离的植物细胞，其包含选自植物细胞中由DCL2、DCL4、RDR1、RDR2和RDR6组成的组中的至少两种基因的所有等位基因中的功能缺失性突变。
根据具体的实施方式，DCL2中的功能缺失性突变包括选自由以下突变所组成的组：
(i)对应于SEQ ID NO:74的核酸残基287-307的缺失；和/或
(ii)在对应于SEQ ID NO:75的核酸残基304-305之间插入至少一个核酸。
根据具体实施方式，DCL4中的功能缺失性突变包括选自由以下突变所组成的组：
(i)对应于SEQ ID NO:76的核酸残基977-983的缺失；
(ii)在对应于SEQ ID NO:76的核酸残基983-984之间插入至少一种核酸；
(ii)对应于SEQ ID NO:77的核酸残基942-949的缺失；和/或
(iii)对应于SEQ ID NO:77的核酸残基944-974的缺失。
根据具体实施方式，DCL2中的功能缺失性突变包括选自由以下突变所组成的组：
(i)对应于SEQ ID NO:74的核酸残基294-304的缺失；
(ii)对应于SEQ ID NO:74的核酸残基263-304的缺失；和/或
(iii)对应于SEQ ID NO:75的核酸残基296-395的缺失
根据具体实施方式，DCL4中的功能缺失性突变包括选自由以下突变所组成的组：
(i)在对应于SEQ ID NO:76的核酸残基983-984之间插入至少一种核酸；
(ii)在对应于SEQ ID NO:76的核酸残基983-984之间插入至少两种核酸；
(iii)对应于SEQ ID NO:77的核酸残基949-1390的缺失；和/或
(iv)在对应于SEQ ID NO:77的核酸残基944-948之间插入至少两种核酸。
根据具体实施方式，DCL2中的功能缺失性突变包括选自由以下突变所组成的组：
(i)对应于SEQ ID NO:74的核酸残基304-897的缺失；
(ii)对应于SEQ ID NO:74的核酸残基281-314的缺失；和/或
(iii)对应于SEQ ID NO:75的核酸残基300-369的缺失。
根据具体实施方式，DCL4中的功能缺失性突变包括选自由以下突变所组成的组：
(i)在对应于SEQ ID NO:76的核酸残基983-984之间缺失至少一种核酸；
(ii)在对应于SEQ ID NO:77的核酸残基948-949之间缺失至少一种核酸；和/或
(iii)在对应于SEQ ID NO:77的核酸残基945-947之间缺失至少三种核酸。
应当理解，本文所述的植物细胞可能已经被进一步遗传修饰以表达目标表达产物。
因此，根据具体实施方式，该方法包括在分离的植物细胞中表达目标重组表达产物。
根据具体的实施方式，分离的植物细胞包含用于表达目标表达产物的异源核酸序列。
如本文所用，术语“异源的(heterologous)”是指至少在定位上不是植物细胞天然的或完全不存在于天然植物细胞中的核酸序列。
根据本公开的一个方面，提供了一种在植物细胞中表达目标重组表达产物的方法，该方法包括培养本文公开的植物细胞，所述植物细胞已经用能够引入本文公开的功能缺失性突变的试剂转化，并且在允许目标表达产物表达的条件下进一步转化以表达目标表达产物(例如多肽)。
这样的条件可以是例如合适的温度(例如37℃)、气氛(例如空气加5％CO2)、pH、光、介质(例如MS-BY-2介质)、碳源和补充剂。
随后，可以根据标准方法纯化和配制产生的表达产(例如多肽)。
根据具体实施方式，目标表达产物不是能够将功能缺失性突变引入本文所述的植物细胞的试剂(例如，沉默试剂)。
根据具体的实施方式，目标表达产物是多肽。
根据具体的实施方式，目标表达产物是哺乳动物多肽。
根据具体的实施方式，目标表达产物是人类多肽。
根据一些实施方式，目标表达产物是药物。
可由本文公开的植物细胞和方法表达的目标多肽的非限制性示例包括：细胞因子、细胞因子受体、生长因子(例如EGF、HER-2、FGF-α、TGF-β、TGF-α、TGF-β、PDGF、IGF-1、IGF-2、NGF)、生长因子受体、生长激素(例如人类生长激素、牛生长激素)；胰岛素(例如，胰岛素A链和胰岛素B链)、胰岛素原(pro-insulin)、促红细胞生成素(erythropoietin，EPO)、集落刺激因子(colony stimulating factors)(例如，G-CSF、GM-CSF、M-CSF)；白细胞介素；血管内皮生长因子(vascular endothelial growth factor，VEGF)及其受体(VEGF-R)、干扰素、肿瘤坏死因子及其受体、血小板生成素(thrombopoietin，TPO)、凝血酶、脑利钠肽(brain natriuretic peptide，BNP)；凝血因子(例如因子VIII、因子IX、冯·维勒布兰德因子(von Willebrands factor)等)、抗凝血因子；组织纤溶酶原激活物(tissueplasminogen activator，TPA)、尿激酶、促卵泡激素(follicle stimulating hormone，FSH)、黄体刺激素(luteinizing hormone，LH)、降钙素、CD蛋白(例如，CD2、CD3、CD4、CD5、CD7、CD8、CDI Ia、CDI Ib、CD18、CD19、CD20、CD25、CD33、CD44、CD45、CD71等)、CTLA蛋白(例如CTLA4)；T细胞和B细胞受体蛋白、骨形态发生蛋白(bone morphogenic proteins)(BNPs，例如BMP-1、BMP-2、BMP-3等)、神经营养因子(neurotrophic factors)(例如骨源性神经营养因子(bone derived neurotrophic factor，BDNF)、神经营养素(neurotrophins)(例如凝乳酶(rennin))、类风湿因子(rheumatoid factor)、趋化因子(RANTES)、白蛋白、松弛素，巨噬细胞抑制蛋白(例如MIP-1、MIP-2)、病毒蛋白或抗原、表面膜蛋白、离子通道蛋白(ionchannel proteins)、酶、调节蛋白(regulatory proteins)、免疫调节蛋白(immunomodulatory proteins)(例如HLA、MHC、B7家族)、归巢受体(homing receptors)、运输蛋白(transport proteins)、超氧化物歧化酶(superoxide dismutase，SOD)、G-蛋白偶联受体蛋白(G-protein coupled receptor proteins，GPCR)、神经调节蛋白(neuromodulatory proteins)、阿尔茨海默病相关蛋白和肽。融合蛋白、嵌合蛋白以及任何前述蛋白和多肽的片段或部分或突变体、突变或类似物也包括在可由本文公开的植物细胞和方法表达的合适多肽中。目标多肽可以是糖蛋白。一类糖蛋白是病毒糖蛋白，特别是亚单位，其可用于生产例如疫苗。病毒蛋白的一些示例包括来自鼻病毒(rhinovirus)；脊髓灰质炎病毒(poliomyelitis virus)；疱疹病毒(herpes virus)；牛疱疹病毒(bovine herpesvirus)；流感病毒(influenza virus)；新城疫病毒(newcastle disease virus)；呼吸道合胞病毒(respiratory syncitio virus)；麻疹病毒(measles virus)；逆转录病毒(retrovirus)，例如人类免疫缺陷病毒或细小病毒或乳多空病毒(papovavirus)；轮状病毒或冠状病毒(例如传染性胃肠炎病毒(transmissable gastroenteritisvirus)或黄病毒(flavivirus)(例如蜱传脑炎病毒(tick-borne encephalitis virus)或黄热病毒(yellowfever virus)))；披膜病毒(togavirus)，例如风疹病毒(rubella virus)或东、西或委内瑞拉马脑脊髓炎病毒(eastern-,western-,or venezuelean equine encephalomyelitisvirus)；引起肝炎病毒，例如甲型肝炎或乙型肝炎病毒；瘟病病毒(pestivirus)，例如猪霍乱病毒，或棒状病毒属(rhabdovirus)(例如狂犬病病毒)。
根据一个具体实施方式，目标多肽是抗体(antibody)。本文所用的术语“抗体”是指重组抗体(例如IgD、IgG、IgA、IgM、IgE类)和重组抗体(例如单链抗体、嵌合和人源化抗体)和多特异性抗体。术语“抗体(antibody)”还指所有前述的片段和衍生物，并且还进一步包括其保留特异性结合表位的能力的其任何修饰的或衍生的变体。抗体衍生物可包含与抗体缀合(conjugated to)的蛋白质或化学部分。单克隆抗体能够选择性地结合靶抗原或表位。抗体的非限制性示例包括单克隆抗体(monoclonal antibodies，mAbs)、人源化或嵌合抗体、骆驼化抗体(camelized antibodies)、骆驼科抗体(camelid antibodies，NanobodiesRTM)、单链抗体(single chain antibodies，scFv)、Fab片段、F(ab')2片段、二硫键连接的Fvs(sdFv)片段、抗独特型(anti-idiotypic，anti-Id)抗体、体内抗体、合成抗体和上述任一种的表位结合片段。术语“抗体(antibody)”还指包括与免疫球蛋白的Fc区域等同的区域的融合蛋白。还设想在植物细胞中生产所谓的双特异性抗体(dual-specificity antibodies)(Bostrom J等人(2009)科学(Science)323,1610-1614)。
在本公开范围内的抗体的非限制性示例包括包含以下抗体的氨基酸序列的那些抗体：抗TNFα抗体，例如阿达木单抗(Adalimumab)(HumiraTM)；抗HER2抗体，包括包含重链和轻链可变区的抗体(参见美国专利US5,725,856)，或曲妥珠单抗(Trastuzumab)，例如HERCEPTINTM；抗-CD20抗体，例如在美国专利US4,739,447中的嵌合抗-CD20、美国专利US 5,721,108中的2H7抗体的嵌合或人源化变体；抗-VEGF抗体，包括人源化和/或亲和成熟的抗-VEGF抗体，例如人源化抗-VEGF抗体huA4.6.1AVASTINTM(WO96/30046和WO98/45331)；抗EGFR(如WO96/40210中的嵌合或人源化抗体)；抗CD3抗体，例如OKT3(美国专利US4,515,893)；抗CD25或抗tac抗体(anti-tac antibodies)，例如CHI-621(SIMULECT)和(Zenapax)(美国专利US5,693,762)。
根据一个具体实施方式，目标多肽是一种酶。
根据具体实施方式，该酶是拉布立酶(rasburicase)。
根据一个具体实施方式，所述酶是溶酶体酶。示例包括但不限于神经酰胺酶(cermidase)，例如N-乙酰半乳糖胺-4-硫酸酯酶(芳基硫酸酯酶B)、α-葡糖脑苷脂酶(α-glucocerebrosidase)、α-L-艾杜糖醛酸酶(α-L-iduronidase)、α-半乳糖苷酶A(alpha-galactosidase A)、β-半乳糖苷酶(beta-galactosidase)。
根据一个具体实施方式，目标多肽是嵌合多肽，例如，附着于异源多肽的目标多肽，该异源多肽不是目标多肽的天然多肽，也称为融合蛋白。示例包括但不限于依那西普(Etanercept)(EnbrelTM)，一种将TNF受体融合至IgG1抗体的恒定末端的嵌合多肽。
应当理解，本文所述的植物细胞可以被进一步修饰以具有的降低的糖基化酶的表达和/或活性。
因此，根据具体实施方式，与具有相同遗传背景但未用下调糖基化酶表达和/或活性的试剂的对照植物细胞相比，该植物细胞具有降低的糖基化酶表达和/或活性。
根据具体实施方式，所述方法包括向分离的植物细胞中引入能够下调糖基化酶的表达和/或活性的试剂。
糖基化酶的示例包括木糖基转移酶和/或岩藻糖基转移酶。
本文所用的“木糖基转移酶(Xylosyltransferase)”缩写为“XylT”是指一种酶，它催化木糖从GDP木糖转移到N-聚糖核心中的β-连接的二等分甘露糖(bisecting mannose)，同时将其与β-1,2糖苷键连接(EC 2.4.2.38)。
本文所用的“岩藻糖基转移酶(Fucosyltransferase)”缩写为“FucT”是指一种酶，它催化岩藻糖从GDP岩藻糖转移到蛋白质结合的N-聚糖(EC 2.4.1.214)的核心α-连接的N-乙酰葡糖胺(N-acetyl glucosamine，GlcNAc)的酶。
烟草(N.tabacum)包含两个XylT基因和5个FucT基因。这些包括：
NTAB-BX_AWOK-Ss596(NTAB-XylT-A,SEQ ID NO:88)；
NTAB-BX_AWOK-Ss12784(NTAB-XylT-B,SEQ ID NO:89)；
NTAB-K326_AWOJ-Ss19752(NTAB-FucT-A,SEQ ID NO:90)；
NTAB-BX_AWOK-Ss16887(NTAB-FucT-B,SEQ ID NO:91)；
NTAB-K326_AWOJ-Ss16744(NTAB-FucT-C,SEQ ID NO:92)；
NTAB-K326_AWOJ-Ss19661(NTAB-FucT-D,SEQ ID NO:93)；
NTAB-K326_AWOJ-Ss19849(NTAB-FucT-E,SEQ ID NO:94)。
如本文所用，“降低的表达和/或活性(reduced expression and/or activity)”或“下调表达和/或活性(downregulating expression and/or activity)”是指与具有相同遗传背景的对照细胞相比，糖基化酶表达和/或活性水平降低了至少10％，所述对照细胞没有经受(或接触)下调糖基化酶的表达和/或活性的试剂，如可以通过例如PCR、ELISA、蛋白质印迹分析、免疫沉淀、流式细胞术、免疫染色或活性测定，例如从PNGaseA获得的寡糖与从PNGaseF获得的寡糖的比较来确定。根据一个具体实施方式，降低至少20％、30％、40％或甚至更高，例如50％、60％、70％、80％、90％或甚至100％。
用于降低(或下调)糖基化酶的表达和/或活性的方法和试剂是本领域熟知的，并且可以使用干扰转录和/或翻译的多种分子(例如RNA沉默试剂，例如：转录基因沉默(transcriptional gene silencing，TGS)、转录后基因沉默(post-transcriptional genesilencing，PTGS)、抑制(quelling)、共抑制(co-suppression)和翻译抑制RNA干扰(RNAi)例如siRNA、miRNA、反义(antisense))在基因组(例如，同源重组和位点特异性内切核酸酶)和/或转录水平上，或者在蛋白质水平(例如，适体(aptamers)、小分子和抑制性肽、拮抗剂(antagonists)、切割多肽的酶、抗体等)上实现。
上文进一步提供了对基因组水平下调的详细描述。在基因组水平上降低木糖基转移酶和/或岩藻糖基转移酶的表达和/或活性的具体方法的非限制性示例公开于如下文献中：例如Hanania U等人，(2017)植物生物技术杂志(Plant Biotechnology Journal)15:1120-1129；Jansing J,Sack M等人(2019)植物生物技术杂志(Plant BiotechnologyJournal)17:350-361；Mercx Sb等人(2017)植物科学中的前沿(Frontiers in plantscience)8:403-403，其内容通过引用完全并入本文。
应当理解，一旦不再需要(例如，在引入功能缺失性突变之后)，可以从分离的植物细胞中除去编码例如本文公开的试剂的异源序列和任选地伴随它们的调节序列和/或选择标记物。本领域已知多种技术用于去除转基因和标记，同时仅留下所需的转基因和标记物。此类方法包括例如：(1)Cas9的瞬时表达(Chen等，2018；Zhang等，2016)；(2)将纯化的Cas9蛋白和向导RNA(RNP)的预组装复合物转染到植物原生质体中(Woo等人，2015)；(3)使用在水稻REG2启动子控制下的“自杀(suicide)”转基因，例如BARNASE基因，其有效杀死所有含有CRISPR-Cas9的花粉和胚胎，确保任何存活的胚胎将不含外源DNA(He等人，2018)，或(4)使CRISPR构建体与RNA干扰元件结合(Coupling)，所述RNA干扰元件靶向水稻中的除草剂抗性酶(Lu等人，2017)，产生无转基因的突变植物。
预期在从本申请开始的专利有效期内，将开发出许多能够降低或消除靶蛋白的表达和/或活性并且在基因中特异性引入功能缺失性突变的许多相关试剂，术语“降低或消除蛋白的表达和/或活性”或“能够引入功能缺失性突变的试剂”的范围旨在包括所有这些先验的新技术。
如本文所用，术语“约(about)”是指±10％。
术语“包括(comprises、comprising、includes、including)”、“具有(having)”及其同源词(conjugates)意为“包括但不限于”。
术语“由.组成”是指“包括且限于”。
术语“由……组成(consisting of)”是为“包括并限于”。
术语“基本上由……组成(consisting essentially of)”意为组合物、方法或结构可包括另外的成分、步骤和/或部分，但前提是另外的成分、步骤和/或部分不会实质性地改变所要求保护的组合物、方法或结构的基本和新颖特性。
如本文所使用，单数形式“一个(a、an)”和“所述(the)”包括复数，除非上下文另有明确的指示。例如，术语“化合物(a compound)”或“至少一种化合物(at least onecompound)”可以包括多种化合物，包括其混合物。
在整个申请中，本公开的各个实施方式可以以范围的形式呈现。应当理解，范围形式的描述仅仅是为了方便和简洁，不应当被解释为对本公开的范围的不可改变的限制。因此，范围的描述应当被认为已经具体公开了所有可能的子范围以及该范围内的单个数值。例如，对诸如1至6的范围的描述应当被认为已经具体公开了子范围，诸如1至3、1至4、1至5、2至4、2至6、3至6等，以及该范围内的单个数字，例如1、2、3、4、5和6。不管范围的宽度如何，都适用。
每当本文指出数值范围时，意为包括在所指出的范围内的任何引用的数字(分数或整数)。表述“第一指示数和第二指示数之间的范围(ranging/ranges between a firstindicate number and a second indicate number)”和“从第一指示数到第二指示数的范围(ranging/ranges from afirst,indicate number“to”a second indicate number)”在本文中可互换使用，意为包括第一指示数字和第二指示数字以及它们之间的所有数和整数。
如本文所用，术语“方法(method)”是指用于完成给定任务的方式、手段、技术和程序，包括但不限于化学、药理学、生物学、生物化学和医学领域的从业人员已知的或者容易从已知的方式、手段、技术和程序开发的那些方式、手段、技术和程序。
当提及特定的序列表时，这种提及应理解为还包括基本上与其互补序列相对应的序列，包括由例如测序错误、克隆错误或导致碱基替换、碱基缺失或碱基添加的其它改变引起的微小序列变异，只要这种变异的频率为50个核苷酸中少于1个；可替代地，100个核苷酸中少于1个；可替代地，200个核苷酸中少于1个；可替代地，500个核苷酸中少于1个；可替代地，1000个核苷酸中少于1个；可替代地，5000个核苷酸中少于一个；可替代地，10,000个核苷酸中少于一个。
应当理解，为了清楚起见，在单独实施方式的上下文中描述的本公开的某些特征也可以在单个实施方式中组合地提供。相反，为了简洁起见，在单个实施方式的上下文中描述的本公开的各个特征也可以单独提供，或者以任何合适的子组合提供，或者以本公开的任何其它描述的实施方式中的合适的方式提供。在各个实施方式的上下文中描述的某些特征不应被认为是这些实施方式的必要特征，除非该实施方式在没有这些元件的情况下不起作用。
如上文所述以及如以下权利要求部分所要求的本公开的各个实施方式和方面在以下实施例中得到实验支持。
实施例
现在参考下面的实施例，这些实施例与上面的描述一起以非限制性的方式说明了本公开的一些实施方式。
通常，本文使用的命名和本公开中使用的实验室方法包括分子、生物化学、微生物和重组DNA技术。这些技术在文献中有详尽的解释。参见，例如：“分子克隆：实验室手册(Molecular Cloning:A laboratory Manual)”Sambrook等人，(1989)；“分子生物学实验(Current Protocols in Molecular Biology)”，第I-III卷，Ausubel,R.M.编(1994)；Ausubel等人，“分子生物学实验(Current Protocols in Molecular Biology)”，约翰威立国际出版公司(John Wiley and Sons,Baltimore,Md.)，巴尔的摩，马里兰州(1989)；Perbal，“分子克隆实用指南(A Practical Guide to Molecular Cloning)”，约翰威立国际出版公司，纽约(1988)；Watson等人，“重组DNA(Recombinant DNA)”，科学美国人书籍(Scientific American Books)，纽约；Birren等人(编辑)，“基因组分析：实验室手册系列(Genome Analysis:A Laboratory Manual Series)”，第1-4卷，冷泉港实验室出版社(ColdSpring Harbor Press)，纽约(1998)；如以下美国专利中所述的方法：US4,666,828、US4,683,202、US4,801,531、US5,192,659和US5,272,057；“细胞生物学：实验室手册(CellBiology:A Laboratory Handbook)”，第I-III卷，Cellis,J.E.编辑(1994)；“当前免疫学方案”卷I-III，Coligan J.E.编辑(1994)；Freshney的“动物细胞培养-基础技术手册(Culture of Animal Cells-A Manual of Basic Technique)”，Freshney,Wiley-Liss,N.Y(1994)，第三版；“当前免疫学方案”卷I-III，Coligan J.E.编辑(1994)；Stites等人编辑，“基础和临床免疫学(Basic and Clinical Immunology)”(第八版)，Appleton&Lange出版社，诺沃克，CT(1994)；Mishell和Shiigi编辑，“细胞免疫学中的选定方法(SelectedMethods in Cellular Immunology)”，曼出版公司(W.H.Freeman andCo.)，纽约(1980)；可用的免疫测定在专利和科学文献中被广泛描述，参见，例如：美国专利US3,791,932、US3,839,153、US3,850,752、US3,850,578、US3,853,987、US3,867,517、US3,879,262、US3,901,654、US3,935,074、US3,984,533、US3,996,345、US4,034,074、US4,098,876、US4,879,219、US5,011,771和US5,281,521；“寡核苷酸合成(Oligonucleotide Synthesis)”，Gait,M.J.编辑(1984)；“核酸杂交(Nucleic Acid Hybridization)”，Hames,B.D.和Higgins S.J.编辑(1985)；“转录与翻译(Transcription and Translation)”，Hames,B.D.,and HigginsS.J.编辑(1984)；“动物细胞培养(Animal Cell Culture)”，Freshney,R.I.编辑(1986)；“固定化细胞和酶(Immobilized Cells and Enzymes)”，IRL出版社(1986)；“分子克隆实用指南(A Practical Guide to Molecular Cloning)”，Perbal,B.(1984)和“酶学方法”，1-317卷，美国学术出版社；“PCR方案：方法和应用指南”，美国学术出版社，圣地亚哥，CA(1990)；Marshak等人，“蛋白质纯化和表征策略-实验室课程手册(Strategies forProtein Purification and Characterization-A Laboratory Course Manual)”，CSHL出版社(1996)；所有这些都通过引用的方式并入本文，如同在本文中完全阐述一样。在本文中还提供了其它的一般参考资料。其中的过程被认为是本领域公知的，是为了方便读者而提供的。其中包含的所有信息通过引用并入本文。
材料和方法
植物细胞悬浮液(Plant cell suspensions)-烟草BY2细胞(Nicotiana tabacumcv Bright Yellow)细胞(Nagata，2004)在25℃下，在液体MS-BY-2培养基(Nagata和Kumagai,1999)中以悬浮培养物的形式培养，同时在回旋振荡器(orbital shaker)上持续搅拌(85rpm)。悬浮液在250毫升锥形瓶中以50毫升的体积生长，并以每周2.5％(v/v)的浓度传代培养。
构建Cas9/sgRNA载体以敲除DCL2和DCL4基因-基于比对分析，设计了两对crRNA：一对靶向DCL2(下文的表1A,SEQ ID NO:1-2)的两个基因，一对靶向共同同源区域(commonhomological region)中的DCL4(下文的表1A,SEQ ID NO:3-4)的两个基因。将四个crRNAs中的每一个都与tracrRNA主链序列(backbone sequence)(SEQ ID NO：5，下文的表1A)融合，从而构建四个sgRNAs(分别命名为sgRNA1-sgRNA4)。使用pBIN19主链载体(backbonevector)构建三种双元载体(binary vectors)，即phCas9-DCL2、phCas9-DCL4和phCas9-DCL2-DCL4(图1A-C)，所述主链载体含有人类密码子优化的Cas9盒和针对DCL2和DCL4基因的适当盒，以及位于IRES序列下游和胭脂碱合成酶基因终止子(nopaline synthaseterminator)上游的新霉素磷酸转移酶(Neomycine phosphotransferase)基因。
表1A：选择作为Cas9靶(crRNAs)的DNA序列。用斜体字母标记存在于3’端并标记的前间隔序列邻近基序(PAM)序列。
构建Cas9/sgRNA载体以敲除RDR1、RDR2、RDR6基因—基于比对分析，设计了三对crRNA：一对靶向RDR1(SEQ ID NO:26-27，下文的表1B)的两个基因，一对靶向RDR2(SEQ IDNO:28-29，下文的表1B)的两个基因，一对靶向共同同源区域中的RDR6(SEQ ID NO:30-31，下文的表1B)的所有三个基因。将6个crRNAs中的每一个都与tracrRNA主链序列(SEQ IDNO:5，上文的表1A)融合，从而构建6个sgRNAs(分别命名为sgRNA11-sgRNA16)。这些gRNA中的每一个都是在U6启动子下构建的，并插入到二元pBIN19主链载体中。
表1B：选择作为Cas9靶(crRNAs)的DNA序列。用斜体字母标记存在于3’末端的前间隔序列邻近基序(PAM)序列。
构建编码拉布立酶的载体-构建了编码曲霉(Aspergillus)(DB00049,SEQ ID NO:95)拉布立酶基因的菜豆黄矮病毒(Bean yellow dwarf virus，BeYDV)表达载体(Chen等人，2011；Mor等人，2002)。具体地，该载体编码复制子起始蛋白(replicon initiatorprotein，Rep)和病毒外壳和运动基因的缺失，包含在CaMV 35S启动子和章鱼碱合酶终止子的控制下拉布立酶表达盒的插入。(Chen et al.,2011；Mor et al.,2002)
细胞的转化和系的选择-最终的载体用于通过农杆菌植物转化方法转化烟草(tobacco)细胞(An，1985)。一旦建立了稳定的转基因细胞悬浮液，就对其进行转基因表达测试，作为池(pools)或用于分离和筛选单个细胞系(克隆)。通过使用高度稀释的转基因细胞悬浮液的等分试样并将其铺展在固体培养基上来建立单独的细胞系。使细胞生长直至形成小愈伤组织。然后将代表单个克隆的每个愈伤组织重新悬浮在液体培养基中，并取样。
AFLP测定-使用植物DNA小量提取试剂盒(DNeasy plant mini kit)(Qiagen)。使用适当的正向和反向引物(下文的表2，SEQ号6-7)，根据以下方法进行35个循环的PCR扩增：95℃进行1分钟、60℃进行20秒，以及72℃进行1分钟。然后，在1X TBE 15％聚丙烯酰胺凝胶电泳(Polyacrylamide Gel Electrophoresis，PAGE)上分离5μl的每个样品，然后用溴化乙锭(ethidium bromide)染色5分钟。
RFLP测定-使用植物DNA小量提取试剂盒(Qiagen)提取基因组DNA。使用适当的正向和反向引物(下文的表2，SEQ号8-11)，根据以下方法进行35个循环的PCR扩增：95℃进行1分钟、60℃进行20秒，以及72℃进行1分钟。然后，通过使用10微升PCR产物、3微升限制性缓冲液、2微升酶和15微升DDW，使用限制性内切酶E.conI或PspFI消化PCR产物来完成。通过在溴化乙锭染色的2％琼脂糖凝胶上电泳来分离消化的产物。
DNA测序-使用植物DNA小量提取试剂盒(Qiagen)提取基因组DNA。使用适当的正向(forward)和反向(reverse)引物(下文的表2，SEQ号12-19)，根据以下方法进行35个循环的PCR扩增：95℃进行1分钟、60℃进行20秒，以及72℃进行1分钟。然后，将PCR产物亚克隆(sub-cloned)到pGEMT载体中。通过桑格法(Sanger method)对菌落进行测序，并与野生型靶序列进行比对以确定突变。
表2：用于通过DCL2和DCL4基因的RFLP和AFLP测定鉴定和表征基因插入或删除(indels)以及用于DCL2和DCL4基因突变测序的引物。
siRNA检测(siRNA detection)-根据制造商说明，使用mirPreimer-miRNA提取试剂盒(mirPreimer-miRNA isolation kit)(Sigma SNC50-1kt)分离微小RNA(microRNA，miRNA)。向5μl miRNA样品中加入5μl的2X负载染料，并将样品在90℃下加热5分钟以使RNA变性，然后置于冰上。随后，样品在15％聚丙烯酰胺MOPS 7M-尿素凝胶上以100v在20mMMOPS中分离2.5小时。使用半干转印槽(semi dry transferring cell)、Bio-rad仪器将miRNA转移到带正电的尼龙膜(REF11417240001Roche)上，随后用EDC[1-乙基-3-(3-二甲基氨基丙基)碳二亚胺]交联该膜。
为了合成RNA探针，使用DIG RNA标记试剂盒SP6/T7(Sigma)。将用于转录的DNA模板插入到pGEMT载体中，并确定插入方向。为了获得有义链(sense strand)RNA探针，使用SP6或T7聚合酶。使用具有Image LabTM软件版本5.2.1(Bio-Rad)的化学发光成像系统(ChemiDoc Touch Imaging System)(Bio-Rad)，以高分辨率化学发光设置扫描信号强度。
实时RT-PCR-使用植物DNA小量提取试剂盒(DNeasy plant mini kit)(Qiagen)从细胞培养物中提取总RNA，用TURBO Dnase(赛默飞世尔科技公司(Thermo FisherScientific))降解总RNA中的污染的基因组DNA。使用带有Oligo mix/Random(1:3)引物的iSCRIPT select cDNA合成试剂盒(Bio-Rad)，将500ng总RNA用于产生第一链cDNA。
使用15μl TaqMan master mix(Thermo science)、3μl引物和探针的现成混合物(ready mix)、5μl模板cDNA(0.4ng至6.4ng)和7μl ddH2O制备qPCR混合物。在转子基因实时PCR系统(Corbett)中使用合适的正向和反向引物(下文的表3)进行扩增。qPCR反应条件如下：DNA聚合酶在95℃下活化10分钟，接着是40个循环的DNA在95℃下融化(melting)15秒，在60℃下退火(annealing)15秒，以及在72℃下延伸(extension)15秒。
表3：用于实时RT-PCR的引物。
实施例1
构建Cas9/sgRNA载体以敲除DCL2和DCL4基因的所有等位基因
在烟草(Nicotiana tabacum)基因组中，DCL2的两个基因和DCL4的两个基因是公知的(下表4)。为了增加产生突变的可能性，基于比对分析，设计了两对CRISPR小向导RNA(small guide RNAs，sgRNAs)。一对靶向DCL2的两个基因，一对靶向共同同源区域中DCL4的两个基因。因此，定义了以下crRNA：crRNA1、crRNA2-它们在N.tab-DCL2A和N.tab-DCL2B基因(SEQ ID NO:1-2，上表的1A)之间各自共有20bp长；crRNA3、crRNA4-它们在N.tab-DCL4A和N.tab-DCL4B基因(SEQ ID NO:3-4，上表的1A)之间各自共有20bp长。每个构建的crRNA被设计成与互补于靶基因的链杂交，因此其序列属于靶的选定的共同同源区域(图16)。对于CRISPR/Cas9技术的应用，四个crRNA各自融合到tracrRNA主链序列(SEQ ID NO:5，上文的1A表)上，从而构建四个sgRNAs(分别命名为sgRNA1-sgRNA4)。然后构建三个双元载体，即phCas9-DCL2(图1A)、phCas9-DCL4(图1B)和phCas9-DCL2-DCL4(图1C)，并用于三个单独的细胞转化，旨在敲除同一细胞内的BY2-DCL2基因、BY2-DCL4基因或两种基因。
随后，为了评估与野生型细胞系相比，敲除DCL2和DCL4基因是否诱导重组蛋白的更高表达量，选择了两种方法。在第一种方法中，将三种构建的载体用于表达重组蛋白的预转化的BY2细胞的三种单独的稳定转化(下文实施例2)。在第二种方法中，将phCas9-DCL2-DCL4载体转化到BY2细胞中，选择敲除系，然后再转化以表达重组蛋白(下文实施例3)。
表4：烟草(N.tabacum)DCL2和DCL4基因家族的详细信息
实施例2
敲除表达重组蛋白的细胞中所有的DCL2和DCL4等位基因上调重组蛋白的表达
使用菜豆黄矮病毒(BeYDV)表达载体，通过农杆菌转化BY2细胞，以表达曲霉拉布立酶基因(DB00049)。总共分离了100个单独的转化细胞系，并筛选了重组拉布立酶的表达。表达较高水平拉布立酶的系(系40)之一，用于进一步敲除DCL2和/或DCL4基因。因此，在第二次转化中，用三个双元载体：phCas9-DCL2、phCas9-DCL4或phCas9-DCL2-DCL4(图1A-C)，通过农杆菌转化系40。得到的系40的转基因细胞池分别命名为ΔD2、ΔD4和ΔD2ΔD4(Chen等人，2011；Mor等人，2002)。
随后，测试了DCL2和/或DCL4缺失对重组拉布立酶表达水平的影响。具体而言，在转化后8周收集细胞池，并通过活性测试拉布立酶的表达水平。拉布立酶在ΔD2ΔD4细胞中的表达水平比野生型系40中的表达水平高5倍，而拉布立酶在ΔD2或ΔD4细胞中的表达水平比野生型系40中的表达水平高约2倍(图2)。重要的是，在ΔD2ΔD4、ΔD2或ΔD4细胞与野生型系40细胞之间没有显著的形态学或生长速率差异。
在下一步中，从转化的ΔD2ΔD4混合细胞(pooled cells)中分离出总共72个单独的细胞系，并测试了拉布立酶的表达水平。与原始系40相比，这些系中的25个(约35％)表达了2至9倍高水平的拉布立酶(图3)。选择系3、18、34、58和65用于进一步分析，如下文进一步描述的。从所混合的细胞中，总共分离出23个单独的细胞系，并测试了拉布立酶的表达水平。与原始系40相比，这些系中的6个(约26％)表现出更高的水平(图4)。选择显示最高相对水平的系4用于进一步分析，如下文进一步描述的。
对选择的ΔD2ΔD4系3、18、34、58和65进行分析，以检测DCL2和DCL4基因中的基因插入或删除(indels)。为了鉴定和表征DCL2基因中的靶向突变，应用AFLP分析(Liu等人，2015)。PCR引物(SEQ ID NO:6-7，上文表2)设计在DCL2-gRNA1靶位点的侧翼，以产生104bp的野生型基因产物。实际上，从野生型BY2细胞获得的PCR产物长104bp。然而，来自ΔD2ΔD4系3、18、34、58和65的PCR产物比预期大小更短和/或更长(图5A-B)，表明这些系中所有DCL2基因的基因插入或删除(indels)。为了鉴定和表征DCL4基因中的靶向突变，应用RFLP分析，其用于评估具有跨越与NGG邻近的最后核苷酸的限制性位点的靶基因座(Liu等人，2015)。PCR引物(SEQ ID NO:8-9，上文表2)设计在与DCL4-gRNA3靶位点的侧翼，产生269bp的产物。然后用识别野生型靶序列的限制性内切酶EcoNI消化扩增子，产生180bp和89bp的两个片段。预期引入的突变对限制性内切酶消化有抗性，由于限制性位点的缺失而导致未切割的条带。事实上，尽管预期的两个片段是从野生型BY2细胞中获得的，但未切割的条带是从系3、18、34和65中获得的(图6A-B)，表明在这些系中所有的DCL2基因中都存在基因插入或删除(indels)。在系58中未切割的条带也很明显。该系也显示出类似于野生型模式的微弱条带。然而，系58中这两条带的存在不一定表明没有突变，因为在限制性内切酶EcoNI识别位点内存在5个随机N-核苷酸的序列。在Cas9突变是该随机5N序列中核苷酸的取代(即，不插入或缺失)的情况下，酶仍可消化突变位点，因此即使发生突变，消化也将表现为野生型消化。为了分析是否是这种情况，需要对靶gRNA区域进行测序。
在细胞系18和65中，DCL2和DCL4基因中Cas9产生的突变通过测序进一步表征。具体地，为了对DCL2基因中的突变进行序列测定，使用位于DCL2基因的gRNA1 Cas9靶位点侧翼的一组引物(SEQ ID NO:12-13，上表2)和位于两个DCL2基因的gRNA1-gRNA2 Cas9靶位点侧翼的引物(SEQ ID NO:14-15，上文表2)进行PCR。为了对DCL4基因中的突变进行序列测定，使用位于DCL4基因的gRNA3 Cas9靶位点侧翼的一组引物(SEQ ID NO:16-17，上表2)和位于两个DCL4基因的gRNA3-gRNA4 Cas9靶位点侧翼的引物(SEQ ID NO:18-19，上文表2)进行PCR。随后，将获得的PCR产物克隆到pGEMT载体中，并对亚克隆进行测序，揭示了存在不同种类的插入和/或缺失：
-系18：在任何被测基因中都没有检测到野生型产物。鉴定出DCL2基因的两个突变。在DCL2A的两个等位基因中都鉴定出1bp插入突变和12bp缺失突变(图7A)。没有从所有亚克隆获得DCL2B的PCR产物，这可能发生在长段缺失(long deletion)的情况下。鉴定出DCL4基因的三个突变。在DCL4A的一个等位基因中鉴定到1bp插入和7bp缺失的突变。没有从所有亚克隆获得DCL4A的第二等位基因的PCR产物，这可能发生在长段缺失的情况下，另外，在DCL4B的两个等位基因中都鉴定到8bp缺失突变和31bp缺失突变(图7B)。
-系65：在任何被测基因中都没有检测到野生型产物。鉴定出DCL2基因的三个突变，在DCL2A的两个等位基因中都鉴定出11bp缺失突变和42bp缺失突变；在DCL2B的一个等位基因中鉴定到2,721bp缺失突变(图8A)。没有从所有亚克隆获得DCL2B的第二等位基因的PCR产物，这可能发生在长段缺失的情况下。鉴定出DCL4基因的4个突变。在两个DCL4A等位基因中均鉴定出1bp插入突变和2bp插入突变；在两个DCL4B等位基因DCL4B中均鉴定出8,378bp缺失突变和2bp插入突变(图8B)。
随后，为了证实在DCL2和DCL4基因中引入的突变确实是导致重组拉布酸酶重组表达增强的功能缺失性突变，进一步分析了所选择的表达高水平拉布酸酶的ΔD2ΔD4系3、18、34、58和65(相对于系40，分别为7、7.5、8、9.5和7.5倍，图9A)对小干扰RNA(siRNA)的表达。具体地，提取siRNA，并与拉布酸酶有义序列的RNA探针杂交。原始系40和所选择的ΔD2系4产生了21-nt、22-nt和24-nt siRNA，而所有ΔD2ΔD4系仅产生由DCL3基因获得的24-nt类，而未检测到由DCL2和DCL4基因获得的22-nt和21-nt类(图9B)。这些结果表明，DCL2和DCL4基因在重组拉布酸酶转基因上在允许以一定水平表达的平衡中是有活性的(系40中)，而DCL2和DCL4基因的敲除完全消除了21-nt和22-nt siRNA的产生，并有助于改变平衡并使表达水平增加至少7倍。此外，通过抑制RNA沉默，ΔD2ΔD4系中拉布立酶mRNA的稳定性得到改善，如通过实时RT-PCR确定的，与系40相比，ΔD2ΔD4系中拉布立酶mRNA水平增加。具体而言，ΔD2ΔD4系3、18和34或多或少包含两次；与原始系40相比，系58和65含有大约一倍半倍积累的拉布立酶mRNA(图9C)。
实施例3
在DCL2和DCL4的所有等位基因中包含功能缺失性突变的细胞中表达重组蛋白会产生更高量的重组蛋白
用双元载体phCas9-DCL2-DCL4(图1C)通过农杆菌转化BY2细胞，并将所得转基因细胞池(transgenic cell pool)命名为ΔD2ΔD4。随后，从转化的ΔD2ΔD4混合细胞中分离出总共106个单独的细胞系，并使用AFLP和RFLP方法分析，以检测DCL2和DCL4基因中的基因插入或删除(indels)(Liu等人，2015)。为了检测DCL2基因的靶向突变，设计了位于DCL2-gRNA1靶位点侧翼的一组引物(SEQ ID NO:6-7，上表2)，以在野生型基因中产生104bp产物的产物，用于AFLP测定；并设计了位于DCL2-gRNA2靶位点侧翼的一组引物(SEQ ID NO:10-11，上表2)，以产生718bp的产物，用于RFLP分析。为了检测DCL4基因的靶向突变，设计了位于DCL4-gRNA3靶位点侧翼的一组引物(SEQ ID NO:8-9，上表2)，以产生269bp的产物，用于RFLP测定。在106个筛选的系中，有6个系(系5、35、71、93、97和103)通过AFLP和RFLP分析证实了DCL2和DCL4基因的敲除(图10A-12B)。
具体地，在DCL2的AFLP测定中，在野生型BY2细胞中产生了104bp的DNA片段，而从系35、71和103产生的PCR产物显示出预期大小的较短条带，系5、93和97不产生任何条带(图10A-B)。在DCL2的RFLP测定中，用识别野生型靶序列的限制性酶PspFI消化了718bp的DNA片段，预期产生长度为529bp和189bp的两个片段。在系35、71、93、97和103中获得了未切割的条带，而在系5、103和野生型BY2行中获得了预期的两个片段(图11A-B)。在DCL4的RFLP分析中，用限制性酶EcoNI消化了269bp的DNA片段，该限制性酶EcoNI识别野生型靶序列，并预期产生长为180bp和89bp的两个片段。虽然在野生型BY2中获得了预期的两个片段，但在所有六个系(系5、35、71、93、97和103)中都获得了未切割的条带(图12A-B)。总之，结果表明，所有6个系在DCL2和DCL4基因中都是明显被敲除的。重要的是，在这些系和野生型BY2细胞之间没有显著的形态学或生长速率差异。
在细胞系35中，DCL2和DCL4基因中Cas9产生的突变通过测序进一步表征。具体地，为了对DCL2基因中的突变进行序列测定，使用位于两个DCL2基因的gRNA1 Cas9靶位点侧翼的一组引物(SEQ ID NO:12-13，上表2)，以及位于两个DCL2基因的gRNA1-gRNA2 Cas9靶位点侧翼的引物(SEQ ID NO:14-15，上表2)。为了对DCL4基因中的突变进行测序，使用位于两个DCL4基因的gRNA3 Cas9靶位点侧翼的一组引物(SEQ ID NO:16-17，上表2)。随后，将所获得的PCR产物克隆到pGEMT载体中，并对亚克隆进行测序，揭示了存在不同种类的插入和/或缺失。在任何被测基因中都没有检测到野生型产物。鉴定了DCL2基因的3个突变：在DCL2A的两个等位基因中都鉴定出了2,528bp的缺失突变和34bp的缺失突变，在DCL2B的一个等位基因中鉴定出了70bp的缺失突变。没有从所有亚克隆获得DCL2B的第二等位基因的PCR产物，这可能发生在长段缺失的情况下(图13A)。鉴定出DCL4基因的三个突变。在DCL4A基因的一个等位基因中鉴定到1bp的缺失。没有从所有亚克隆获得DCL4A的第二等位基因的PCR产物，这可能发生在长段缺失的情况下。另外，在DCL4B的两个等位基因中都鉴定到1bp缺失突变和31bp的缺失突变(图13B)。
为了研究DCL2和DCL4敲除对转基因表达水平和基因沉默的影响，使用菜豆黄矮病毒(BeYDV)表达载体，通过农杆菌再次转化(re-transformed)野生型BY2细胞和由此产生的六个转基因细胞系，用于表达曲霉拉布立酶基因(DB00049)(Chen等人，2011；Mor等人，2002)。然后，在转化后8周收集每个再次转化的细胞系的池，并通过活性测试拉布立酶的表达水平。与野生型BY2相比，在所有系的池中获得的拉布立酶表达水平显著增加，范围从系97的池中的5倍至系97的池中的9.6倍(图14A)。与BY2相比，系5、35和93的表达水平增加也通过考马斯染色的凝胶得到证实(图14B)。简言之，从合适的系中提取总蛋白质，并在SDS聚丙烯酰胺凝胶上分离。凝胶用考马斯蓝染色2小时，并在DDW中脱色。与野生型BY2细胞中的相同条带相比，ΔD2ΔD4系中约38kDa处的显著条带更强，表明活性测量中获得的结果的可靠性。
随后，为了证实在DCL2和DCL4基因中引入的突变确实是导致重组拉布酸酶重组表达增强的功能缺失性突变，检查了siRNA分子在选择的ΔD2ΔD4系5、35、71、93和103中的积累。具体地，提取siRNA，并与拉布酸酶有义序列的RNA探针杂交。拉布酸酶转化的野生型BY2细胞产生了21-nt、22-nt和24-nt siRNA，而所有ΔD2ΔD4系仅产生由DCL3基因获得的24-nt类，而未检测到由DCL2和DCL4基因获得的22-nt和21-nt类(图15)。这些结果表明，DCL2和DCL4基因在重组拉布酸酶转基因上在允许以一定水平表达的平衡中是有活性的，而DCL2和DCL4基因的敲除完全消除了21-nt和22-nt siRNA的产生，并有助于改变平衡并使表达水平增加至少9倍。
实施例4
构建Cas9/sgRNA载体以敲除RDR1、RDR2和/或RDR6基因的所有等位基因
在烟草(Nicotiana tabacum)基因组中，RDRα组的7个基因是公知的(下文表5)。基于比对分析，将这些基因分为三个同源组：组1-RDR1-A、B；组2-RDR2-A、B；和组3-RDR6-A、B、C。为了增加产生突变的可能性，基于每组的比对分析设计了两对CRISPR小向导RNA(sgRNAs)。因此，定义了以下crRNAs：crRNA11、crRNA12-在N.tab-RDR1A和N.tab-RDR1B基因(SEQ ID NO:26-27，上表的1B)之间共有19bp和20bp长；crRNA13、crRNA14-在N.tab-RDR2A和N.tab-RDR2B基因(SEQ ID NO:28-29，上表的1B)之间共有20bp和21bp长；以及crRNA15、crRNA16-在N.tab-RDR6A、N.tab-RDR6B和N.tab-RDR6C基因(SEQ ID NO:30-31，上表的1B)之间共有19bp和20bp长。对于CRISPR/Cas9技术的应用，四个crRNA各自融合到tracrRNA主链序列(SEQ ID NO:5，上文的1A表)上，从而构建四个sgRNAs(分别命名为sgRNA11-sgRNA16)。即将这些gRNA中的每一个都构建成双元载体。
随后，为了评估与野生型细胞系相比，敲除RDR1、RDR2和/或RDR6以及可能与DCL2和/或DCL4基因的组合是否诱导重组蛋白的更高表达量，选择了两种方法，如上文实施例2-3所述。
表5：烟草(N.tabacum)RDR1、RDR2和RDR6基因家族的详细信息
尽管已经结合本公开的具体实施方式描述了本公开，但是显然，对于本领域技术人员来说，许多替代、修改和变化将是显而易见的。因此，旨在包含落入所附权利要求的精神和广泛范围内的所有这些替换、修改和变化。
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序列表
<110> 波塔力克斯有限公司（Protalix Ltd.）
尤里·哈纳尼亚（HANANIA, Uri）
莫尔·舍瓦（SHEVA, Maor）
<120> 切酶样敲除植物细胞（DICER-LIKE KNOCK-OUT PLANT CELLS）
<130> 89444
<150> US 63/087,366
<151> 2020-10-05
<150> US 63/186,280
<151> 2021-05-10
<160> 95
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<223> Single strand DNA oligonucleotide
<400> 10
atatcaacat gtggatattc cgtgcac 27
<210> 11
<211> 27
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 11
tctaacaatc gtttgagcac aaacatc 27
<210> 12
<211> 26
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 12
tacatagctg ttttcttggt cccgac 26
<210> 13
<211> 28
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 13
cttcattatg caggcataag ggtgtttg 28
<210> 14
<211> 25
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 14
tatcagttag aggcattgga gacgg 25
<210> 15
<211> 27
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 15
tctaacaatc gtttgagcac aaacatc 27
<210> 16
<211> 27
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 16
cagtagagta tgcactccag aatcttg 27
<210> 17
<211> 28
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 17
ctgactcaga tatctgtcac acaaagag 28
<210> 18
<211> 27
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 18
cagtagagta tgcactccag aatcttg 27
<210> 19
<211> 26
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 19
cgaaatgctt gatgcagaac tgatgg 26
<210> 20
<211> 24
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 20
gagacgagtt ccagaagtgt atag 24
<210> 21
<211> 21
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 21
ttccttagcc aaatccttcc a 21
<210> 22
<211> 24
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 22
gggagatgct gaggaaggag agga 24
<210> 23
<211> 20
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 23
gctacatggc agtggaagaa 20
<210> 24
<211> 23
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 24
cagcgaatgt cttcaaagta acc 23
<210> 25
<211> 24
<212> DNA
<213> Artificial sequence
<220>
<223> Single strand DNA oligonucleotide
<400> 25
tgctacttgg gctacagcta ggga 24
<210> 26
<211> 22
<212> DNA
<213> Artificial sequence
<220>
<223> crispr RNA (crRNA) nucleic acid sequence
<400> 26
gcatgcattg aacacgcctt gg 22
<210> 27
<211> 23
<212> DNA
<213> Artificial sequence
<220>
<223> crispr RNA (crRNA) nucleic acid sequence
<400> 27
gttgttatga tccagtgagg tgg 23
<210> 28
<211> 23
<212> DNA
<213> Artificial sequence
<220>
<223> crispr RNA (crRNA) nucleic acid sequence
<400> 28
gaaactcttt ggtatagctt tgg 23
<210> 29
<211> 24
<212> DNA
<213> Artificial sequence
<220>
<223> crispr RNA (crRNA) nucleic acid sequence
<400> 29
gcttcaaagt tcagttctga ccgg 24
<210> 30
<211> 22
<212> DNA
<213> Artificial sequence
<220>
<223> crispr RNA (crRNA) nucleic acid sequence
<400> 30
gaaatctgca acgcacatgt gg 22
<210> 31
<211> 23
<212> DNA
<213> Artificial sequence
<220>
<223> crispr RNA (crRNA) nucleic acid sequence
<400> 31
ggatgagaag tgcctaaaat tgg 23
<210> 32
<211> 5
<212> PRT
<213> Artificial sequence
<220>
<223> C-terminal canonical catalytic domain amino acid sequence
<400> 32
Asp Leu Asp Gly Asp
1 5
<210> 33
<211> 34
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 33
tggtgaaggc tagttgcatc ctcttaaagg ggga 34
<210> 34
<211> 53
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 34
catactcact tgaaagtggg caagtattgg ggagaaatgg gtgtcgatta ttg 53
<210> 35
<211> 54
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 35
catactgact tgaaagtggg caagtattgg ggagaaaatg ggtgtcgatt attg 54
<210> 36
<211> 32
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 36
catactgact tgaaagtggg tgtcgattat tg 32
<210> 37
<211> 51
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 37
ttgcaccctt gttttggtga aggctagttg catcctctta aagggggatc a 51
<210> 38
<211> 45
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 38
ttgcaccctt gttttggtga aggctagttg caaaaagggg gatca 45
<210> 39
<211> 54
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 39
ggaaggctag ttgcatcctc ttaaaggggg atcactatga gcgccatcaa atgg 54
<210> 40
<211> 46
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 40
ggaaggctag ttgcataggg ggatcactat gagcgccatc aaatgg 46
<210> 41
<211> 23
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 41
ggaaggctag ttgcatccaa tgg 23
<210> 42
<211> 59
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 42
gctctcatta tgcatactga cttgaaagtg ggcaagtatt ggggagaaat gggtgtcga 59
<210> 43
<211> 48
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 43
gctctcatta tgcatactga cttgaaagtg ggcaaaaatg ggtgtcga 48
<210> 44
<211> 17
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 44
gctcaaatgg gtgtcga 17
<210> 45
<211> 75
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 45
agtgggcaag tattggggag aaatgggttg tttgagtgag ctgggtgttt ggctgacttt 60
caaggtaata agttc 75
<210> 46
<211> 13
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 46
agtgggcaag ttc 13
<210> 47
<211> 34
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 47
tgaaggctag ttgcatcctc ttaaaggggg atca 34
<210> 48
<211> 35
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 48
tgaaggctag ttgcatcctc ttaaaagggg gatca 35
<210> 49
<211> 36
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 49
tgaaggctag ttgcatcctc ttaaaaaggg ggatca 36
<210> 50
<211> 61
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 50
tgaaggctag ttgcatcctc ttaaaggggg atcaggttgc caccaaagtt ggcgaggaag 60
g 61
<210> 51
<211> 30
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 51
tgaaggctag ttgcatcctc ttaaggaagg 30
<210> 52
<211> 36
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 52
tgaaggctag ttgcatcctc ttaaaaaggg ggatca 36
<210> 53
<211> 33
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 53
tattttgttt gagtgagctg ggtgtttggc cgg 33
<210> 54
<211> 69
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 54
acttgaaagt gggcaagtat tggggagaaa tggagtgttt gagtgagctg ggtgtttggc 60
cggctttca 69
<210> 55
<211> 37
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 55
acttgaaagt gggcaagtat tggggaggtt tggccgg 37
<210> 56
<211> 69
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 56
acttgaaagt gggcaagtat tggggagaaa tggagtgttt gagtgagctg ggtgtttggc 60
cggctttca 69
<210> 57
<211> 22
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 57
acttgaaagt gggcaagtat tg 22
<210> 58
<211> 40
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 58
tggtgaaggc tagttgcatc ctcttaaagg gggatcacta 40
<210> 59
<211> 27
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 59
tggtgaaggc tagttgcatc ctctaaa 27
<210> 60
<211> 49
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 60
tggtgaaggc tagttgcatc ctcttaaagg gggatcacta tgagcgcca 49
<210> 61
<211> 48
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 61
tggtgaaggc tagttgcatc ctcttaaggg ggatcactat gagcgcca 48
<210> 62
<211> 46
<212> DNA
<213> Artificial sequence
<220>
<223> sequencing products (nucleic acid sequence)
<400> 62
tggtgaaggc tagttgcatc ctaaaggggg atcactatga gcgcca 46
<210> 63
<211> 84930
<212> DNA
<213> Nicotiana tabacum
<220>
<221> misc_feature
<222> (12218)..(12218)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (22802)..(22802)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (28440)..(28440)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (29634)..(29634)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (33195)..(33195)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (33641)..(33641)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (34400)..(34400)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (36044)..(36044)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (37025)..(37025)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (42114)..(42114)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (71426)..(71463)
<223> n is a, c, g, or t
<400> 63
tatatatata gtaacttata gtactttgtt atgtatattt tgaaatatta actattgtaa 60
cttgtagtac tttttatgta ttttctaaat gtgtaaatgt tatttcaaaa tacctaaaaa 120
aatctatgtc tgaattgaca aaaaaaagtc atttggccct ctaactctga aaaggttcaa 180
acaaattaaa acgaaaggag tgcaatttat cgactattat tttttagagc cgttgaaggt 240
atacatttct cttgtttagt tgtatgttaa tattgtaata ctcctatatt ttatttcatt 300
gttactttaa atactttata gttacaattt atagtattgt aatacaaagg gatttgaaag 360
aagttttcct acttttcaaa gtacaaatgg aaaagatata acgataagcg cgcagggact 420
tcaagatatt gttatatacc gatagtgtaa aagattcttt taccctatca tgtcatctaa 480
atgataatta tagataataa tctatatata ataagtaaaa ttagtgacct gaaaaatacg 540
ataaattacc tgttacaaca tattaaaatc attgatagtg tgaaaagttc tttacattat 600
tgttgtatat gaattaaatc caaattaaaa caagtatttt ccctttcttc taggtaatat 660
caattagaga ccaaaaataa aatataaaat agtatagtag ttatttgtag tggaataaat 720
tgagtcaaat tttttccaag aaaatagtac aaaaaaagag caaaataaga aattgttgtg 780
aggtgatcca acttttaagg gaaaaaagga attcagacat tcaaagattt attgaatggt 840
atctcctttt ttgtagacat tttcaaaggt aaccatagac caaaattata tggttgtata 900
taaatgaatg gtagaggttt caaataagca aacattaata attctctctc tttcaacacc 960
cgagccttat aaatatttaa ggggattgaa agagggagat agaaaccgac gtttttgtgt 1020
atttggagat tccaagaaaa gtgaaaaagt aaaataaaca acaaaaaaat aaggagagag 1080
acagagcaat tctgcaaata agtctctctc catttatttt ttttaacaag aaagcttttt 1140
tagtctttct tgttttttct catgtgttga aaaaaatatt aattttcctt ctcttggttc 1200
ctcttattaa attatcatca tgacgtctaa tttatcatta gaagatataa aaaatgagca 1260
agttgacctt gtaagttaca tctctaattc tccttatctc ttttttcccc ttgtatattt 1320
ttcattttct tgaatttttt tactacatat acctcgcatt aggggcacaa gctaattcag 1380
tttctagagt taatgagttt aaaatgaatt tgatcgtata tgtatatatt ctattttttt 1440
tgttgcataa atatatacat agttcgagtc gaaagcaata agtttagtta aactggctct 1500
aataagatgc atgtcatgga gaccacatat tatacatgca caagcactta cctttggaaa 1560
gagtacatca tgcattaggg gcatgtcacg tagaccatat attatacgtc gcggacacca 1620
tgcattaaga ggcatgtcac gtagaccata tattatatgt cgcggacacc atgcatcggg 1680
ggcatgtcac gtagaccata tattatatgt cgcggacacc atgcatcggg ggcatgtcac 1740
gtagaccata tattattcgt agcgaacacc atgcattagg ggcatgtcac gtagacccta 1800
tattatacgt cgcagacact tataatgaca atgcaaatat tttttatatt attagtgtaa 1860
ttttaatatg tgataacagg ttagttattt ttaattaagc agttgaaaat gatatattga 1920
atgaatgtgc aggaaaacat tccggtggag gaagtgtttc agcagctaaa atgtagcaaa 1980
gaaggattat catctgaaga gggccaaaaa aggatccaaa tatttggccc caacaaactt 2040
gaagagaaaa aggtagtctt tttttgttca ttaataatct tcatattcta ttttaattaa 2100
atcttgaata ttagcattaa taatttatgt ttttttctaa ttgtaggaga acaagcttct 2160
caaattcttg gggtttatgt ggaatcctct ctcatgggtt atggaatcag ctgctattat 2220
ggccattgtt ttggccaatg gaggagtaat tacaatatta acttatacag ttatttttta 2280
tattaataag gttaattagt gcataattag taatggagaa atcttcaaaa aaatgcaggg 2340
caagccaccg gattggccag atttcgttgg tatcactgta ttgctcataa tcaactctac 2400
tatcagtttt attgaagaaa ataatgcagg aaatgctgca gcttccctta tggctaatct 2460
tgctcccaaa actaaggtat cccataattc attatcatac atgctttagt gagaggtcag 2520
aagcggtaag attcagactt aatgagttca atctttatgt tttcatcgct gaactcagtg 2580
gacttttgca ataatggctt caagatttaa tatttgttaa aattttaatg attttcacgt 2640
atatatctat gatccgtgtg aaatatgatg gttcagttga agccattgaa cctatattgc 2700
ttccgcctct agtttagtcc tctacagaga cggatacaac atattaacac cgtgttcatc 2760
tgaatccaat actttcagtt tggagtataa atttatgtgt aaaaattcac taaaattgct 2820
atatatagta ggtctgaacc cataatttta gaaatataat agattcaatg ctaagaatct 2880
taaagattga acctatagag ttagattctg gctccgcctt tggtcctcta tcgatttctt 2940
aatgtgctat gatgatattg atcataatct ttgaaaaaat ttgtgactta attcagattc 3000
tgagagatgg aaaatggtca gaggaggatg cctcaatctt ggttccaggt gatcttatta 3060
gtatcaagtt gggagatatt gtcccagccg atgctcgtct tcttgagggt gatcccctca 3120
agattgatca ggctgcactc actggtgagt ccttacctgt gacaaagttc cctggggctg 3180
aggttttctc tggttccact gtcaagcaag gagaaatcga ggcagtagtc atcgctactg 3240
gtgttcacac cttctttgga aaggctgctc atcttgtaga tagcacaaac caagttggtc 3300
atttccaaaa ggtaaaagaa aataactaat gatttgtggt ctgaagttaa agattcactt 3360
aattcttgaa aaaacgattg tgatttggga ttctgaactt tggctggatt gcgatgatca 3420
ggtattgact gcaatcggaa acttctgtat ctgctctatt gctgtgggaa tggtgattga 3480
gatagtggtt atgtacccaa tccaaaggcg caaatataga gatggaattg acaacttgct 3540
tgtgttgctt atcggaggta tcccaattgc catgccaaca gtcttgtctg tgacaatggc 3600
tattggatct cataggcttg cacaacaagg tgccattaca aagagaatga ctgcaattga 3660
ggaaatggcc ggtatggatg tcctttgcag tgacaagacc ggtactctca ccctcaacaa 3720
gctcaccgtt gacaaaaatt tgattgaggt tggtaatcag gacaacgttg tacctttttt 3780
cgtgattatt atagttatat ttgaggaaat atgaaggcga aaacgttatc aatgtttggt 3840
ggttgtaggt tttccctaaa gatgcggaca aggataccgt tatgttactt gctgctaggg 3900
cttccagggt tgaaaaccaa gatgctatcg atgcttgcat cgttaacatg ttgggtgatc 3960
ccaaggaggt aatatatttt atcatgaggt gatattagta gttttttcac tattccaaga 4020
aattgtaaaa tggcattata tgcttcttgg aactttgcag gcaagatcag gcatccaaga 4080
ggttcatttc ttacctttca atccggttga aaagcgcaca gcaattacat atattgatga 4140
caaaggaaac tggcacaggg ctagcaaagg agctcctgag caagtacgat agtgtttcta 4200
tatttgcctt cacttcatgt atttcctgtg ttcggcatct catctgccgt taccctttgc 4260
cagattattg aactttgtga gctcaaagga gatatcagga agaagtcctt agatatcatc 4320
gacagctatg ccaaccgtgg tcttcgttcc ttggctgtgg caagacaggt aaactaacat 4380
actgttagat aactctgttt ggataagtgc atcatattat tgattgtcgt taactaagca 4440
tgaatacatg atatttatgc agactgtacc agaaaagagc aaggaaagcg atggttcacc 4500
ttgggaattc gttggccttc tgcccctttt tgatcctcca aggcatgaca gtgctgaaac 4560
aatccgcaaa gctcttgatc ttggtgttaa tgttaagatg atcactggtg accagctcgc 4620
catcggtaag gaaactgccc gtaggcttgg catgggaacc aacatgtatc cttcttcagc 4680
tcttcttgga gagcacaaag atgcagccat tgcttcaatt cctgtcgatg agctcattga 4740
aaaggcagat ggttttgccg gagtcttccc aggtaaatat tagtagtact atcattgaac 4800
tacaatatag aaaagtttag gcaaaagaac taacataaaa aggtttgatt ttgtgtagag 4860
cataaatatg agattgtgaa gaagctccaa gaaagaaacc atatctgcgg tatgacagga 4920
gatggagtga acgatgcacc agcactaaag aaggcagaca ttggtattgc tgtcgatgat 4980
gcaacagacg ctgccaggag tgcatctgat atcgtcttga ctgaaccagg tcttagtgtt 5040
atcgtgagtg ctgtgttgac aagcagagcc atcttccaga ggatgaagaa ctacaccatc 5100
tatgcagttt ccatcacaat ccgtgtcgtt atgggattca tgctcattgc ccttatctgg 5160
aagttcgact tctcgccatt catggtcctt atcattgcca tactcaatga tggaactatc 5220
atgaccatct ctaaggacag ggtgaaacca tctccattgc ccgattcgtg gaaactcaaa 5280
gaaatctttg ccactggtgt tgtactcggg acctaccaag cgatcatgac tgttgtgttc 5340
ttctaccttg cagctgacac tgatttcttc tctgtatgtt attctccccc taaacttaaa 5400
caaaaattga aaacataaca tgaaataaac taacaaattt tatcatatat gtgcaggaaa 5460
acttccatgt tagatcaatc agaaactctc caactgagct tacagctgca ctataccttc 5520
aagtgagcat tattagtcaa gctctcatct ttgtgaccag atcaagaagc tggtcattcg 5580
tcgaacgccc tggccttatg cttgttgctg ccttctttgc cgcccaattg gtaaggatct 5640
tgaaaaatga attacttgac ttggttttta atgtgttgtt ctatcggaaa cagcctctct 5700
accttctcga aggtagggga aggtctgcgt acaccccccg actccacatt atgggattac 5760
actgggtttg ttgttgttgg ttttcaatat gtggctacct gaaattcata attttctcct 5820
attttttcca ggttgctacc gtgctcgctg tatatgcaaa ctgggaattt gccaggatca 5880
agggagttgg ttggggatgg gcagcagtta tctggatcta cactattatt acctatatcc 5940
ctcttgatat tcttaaattc atcatccgtt tcgctttgag tggaagggca tgggattcaa 6000
tgatccagaa caaggtaaaa gaagcaacaa aaattgacat aacatgaaca tttccattga 6060
attctattct tgactaatta gtaatatcat ttcttgaata tattagactg ccttcacaac 6120
caagaaggac tatggaaggg gtgaaaggga agcacaatgg gctttagctc aacgtacact 6180
tcacggtctc cagacaccag aaaacactgg cctattcaat gacaagaact acagggaatt 6240
gtccgagatt gccgagcagg ctaaacgtcg tgctgaagtt gcaaggtata tgaacaatat 6300
catagatgct aaattaaaaa gggcagtcag gtgcacaaaa catcttgcat tcatgcaggg 6360
tccagggaag ggccgcaccc caagagagtg tgatgtaggc agcctaatgc aagcatcagt 6420
ggctgattcc acggctcgaa cccctgacct ataggtcaca cggagacaat ttaactgttg 6480
ctccaaggac agcccggtgc acaaagtatc tcacatgcac acagggtcca gggaagggtc 6540
gcaccccaag agggtgtgat gtaagcagcc taatgcaagc atcagtggct gatttcacgg 6600
gtcgaactcc tgagctatag gtcacacgga gacaacttga ctgttgctcc aaggacagcc 6660
ccgtgcacaa agtatcccac attcacgaag ggtccaagta agggccgcac cccaataggg 6720
tgtgatgtag gcagcctaat gcaagcaaca atgactgatt ccacggctcg aacccctgac 6780
ctataggtca cacgaacaca acttgaccgc tgctccaagg acctattgat gtgaaattac 6840
tatgataaat tgttttgagt gacacaaacc tatacttaca agaactatgt tattgcaggt 6900
tgagagagct acacactcta aagggacatg ttgaatcagt ggtcaagcta aagggactag 6960
atattgaaac aatccaacaa cactatactg tctaaagaag ctgcaaatca aatcaacttt 7020
ctttttttcc catataagga tggacatttt tcagctggca ttatgttgga tgaggatatt 7080
gttttgttga acaacaaagg gatagctgtt catttaaaaa aaaatcttga gtattaacag 7140
ttatctatag aaaaaaatag aaaataaaag aaaaaaattg taactagtag ttattttgta 7200
tagtaattta tcctatctat atgttgtatg ctatatctta tttggttaga acaaatctct 7260
ttgtctccac aatcttttga attactttgt gttgcaaatg gagttcctct atagaaatga 7320
ttattattat ttttttttgc ggcaaatcaa taaatgagag ttgatgcaga taaagggagt 7380
agagtgacat gaaaagcaat ggaaaaaata tgtagttatg tatatgtaat aggttgaaga 7440
tgttattgta ataatgtagt ttgtaaggtt attgggaata ttaatagaaa taacctactt 7500
atattaatac tatttatagc ttcaatgtgc atgttgtcat gcatggtttc gtcttgcttt 7560
tttcaactaa aagaacaagg aaatacagca aagagaaggg gggaggaaag aatttccttt 7620
ttttttaaag tagaataaaa taaagatgaa gaatattata aataaatctt gtaaagaaaa 7680
ttaaagaagc ctgcaattta tggcctcact tgcacaaaaa gaaaagatta attaaccaat 7740
caactctatc tggatcccaa attatttgaa gcaagttgtt aataaaagca attaattttg 7800
gttccaaggc tttctaagaa aacaaagaca tccatttttt ttttcaattc acaaacttat 7860
gtttaaattc tattattcct ggttattatc aaactttatt aagggtgaag aactcatagt 7920
tgacatgtaa tatagatcaa aacattctct cttatatgac taactagtgg cagttagccc 7980
ttgcttagca ccggcccaat ccaaaacttg aactaattta cattgttctg tgaaaatgta 8040
aagtttggca cactaattaa tacttcctca tgctcccttt aattaatttt ttaatctttt 8100
tttatagtcc acaatatttg atttttcaga tatcaagaaa ggattaattt atttatttta 8160
agttggcctt ggaataaaaa gcctaggagt atttgttata ttttcaatga gtaaattaag 8220
gttaatatgg tcatattgtt aattaatgct aaaaggtgaa ttccataata tatgaaaaca 8280
aacaaaaatt aaattaaagt agaccggagg agtatgtggt tttcgtggca tataaacaac 8340
ttcaattaca tgtgtttcct tattaattat ctcaattaat atcgcccttt taagtaaccc 8400
caaataatag tgaatactac ttccatttta atatgatcat attgagtgca tatgaagttg 8460
taggcccaaa ttcaacataa atctttaatt taatttggat gaacttcatt ttagtaattt 8520
tgtagattct tttttactta ccaattctac gtatttgctg agaaataaaa aaaaataaga 8580
taaccaagaa tttcaattgc actccacatt gtggaattct tgttaaatca agttatttaa 8640
gatggaaaat tgagatttta aattgataga acaaaaatat tttcacagtc cagattatgt 8700
gattcttctt accaatttca tattaagttt ctcatttctg ctacatatac aaagaatagt 8760
aaataacata tttcaacaac acaatagtaa caaccacaac ttacatttaa atgtaaggtc 8820
atacctgaat ttataagtac actaataaaa atattatttg gtccttccgt agaaataata 8880
ttatttttat aatgcactaa ttaatttttt ttcacaaggg cttcccacta cagtcaaagc 8940
tatgggtgct cccgaataac taatgtataa agatgtcgtg tattagagaa aaatatacac 9000
aatcataact tgtcaaagaa gcgaattatt tcatttaaga taaagtttac taatcataac 9060
ttgacaagag tgagttgctc tagtggtaag caccatccac tttcaaccaa gaggttatga 9120
gttcgagtca tcccaagagc agggtgaaga gttcttggag ggatggagcc gagggtctat 9180
cggaaatagc ctctctacct cagggtaggg gtaaggtctg cgtaaactcc actagtggga 9240
ttatactgtt gttgttgttg cattagagaa aaatatacac aatcataact tgtcaaagat 9300
gcgaattatt tcatttaaga taaagtttac aaatatgata cacatggcat ttcttgctat 9360
ttccaaaata cttgatactc tatgaaagaa agaaaaaata gtagttcgtt cttttattca 9420
cttcaactta atcttctcaa caaccattca taagcgatga tatattattt tgttcgtcat 9480
tttacagcct gctcttcaaa aagtaatttt gttaactcat gatttgtaag aaaggatact 9540
ccactaacat acttaaaata tgagaaatac atcacataag cataaggtga gctacctatt 9600
attggcaata caatctaaac cattcctgaa atatttgtaa agttctttgc ttctttttgt 9660
gttgtatgtt agaaatttct tatgacattc taaagtacca aataattagt gtagattttc 9720
aaataggatc aattctaata gcaaaagaaa ataaagtctt agtgttattc tccactttgc 9780
acaagaaatt ttcgaagaga ataaaaatta agctcaaata ttttattgat ttagtcaaac 9840
caagtaaact caattaacct taaaataatt gtccaccttc ttttctctaa gaaataaatt 9900
aaatcaaagt taaagcggag aaaatacaaa ttcaaaaagg ctaaggatag aattcaaaag 9960
gctttcaatt ttagaaagct aggcacatat atcaaaaacc caaaagctta atgaaggaac 10020
tgtatattgc tagttacata aataccctat aggcccaggt tacaaagtca gcatataatt 10080
ggcattttaa ctaagatcct gattttttct gtcattagcc atgttgaccc gaagctcctt 10140
aaactgtgcc ttattaatag taggaatgta ctgctgatct tcaaaaataa aaataaaaat 10200
aaaaataaaa aacttctgtt ttacttgcta aaaagccttc tgacttaaca cataaaaact 10260
actacactac atcattgtta aaagttctga actttagtta catcttttgt gcttttgcac 10320
aatacaataa tgactgcgcc tcaattccaa gcaaattaga tgtgactaat aagattacac 10380
aaccagaaac aaaaccagat atgcttttgc accatacaaa acataaagta attagttttc 10440
tctattcttt tagcaaccca acaacctacc attacattaa tatacattta cattaaaaaa 10500
tttgttgtta caataataga gcaagactat catttcccac tagaaaggaa gtgaagttgt 10560
tggagagacc gctagccaca acagcaacta ctacgcctca attcaagtaa gtttctggtc 10620
aattatatga tttctcacta tccatatcgc tccattaaga actactacaa cgctcaatcc 10680
caagcaggtt tggggtcggc tatatgaatc atcattgtcc atgtcgctcc atttaagccc 10740
attctggtcc aatattatta taagaaaaat aatgaggaca tttgacgttc tcttctccta 10800
ctgcttcact ctatgtttcc atgaagttag ttcagaaggg atcaagtctt cattacatga 10860
aagaacagcc tttgccatta gttttccaag ccaagcatgg tagaacaaac ccctggaacc 10920
aaggcctgta aataaccagt acttacactt gctccgacaa ccaatgaatt catctataca 10980
acccaagagt ggaggtgatc cttctgcagt gagtggtggc attgccctta gccctgcaca 11040
tgctcctgtt acggtccaat cttttattgc tggatataca gcagatgcct ttggcagtaa 11100
ctcttcaaga gctttagaag cttcttcttc tgggacatgt ctggaataat tcctcgattt 11160
ccattcccac gttgacccca agtacaacgt tcgaggtccc tgaatagcaa gccatgcatc 11220
tgaaagaatg gaaggactgt gctctggata ctcctctctg aagtttatca ttcagaaaaa 11280
cttctaataa gttgcatgtt ggaagcaatg aatgttaaaa taatttcaac caataacttt 11340
gtgccttaga tactcgacat agaagaaaat agcagaggac acatcaaaaa aggttttttt 11400
tttttgttgg gggggggtga tgatgatggt aggttgaaaa ttgaactagg caacaaatcc 11460
ctcatgctag aaatcagaac caactaaact caatcttctc aaataaatat tactgtatac 11520
agatattctg ttatccagaa agaagaataa agggacacaa ggagctggaa tagcttcatg 11580
aagcaacaac aacaagaagc ccagtaattt cccacaggtc cgaaatagca gtttttcacc 11640
cattggcagt ttttagctgt ggattacctt ttggggtaat tgtctaaatt gtgaccatgc 11700
ttttgaaaaa cccgtgtaaa cagctcattt gacacgcctt gctctatgga atgaaatgca 11760
aggtatgaaa acgggaaagt aattacaatt agcctatcac aatcatgaga gacttattgt 11820
catcaaagtc tgatgtacaa tcaagaaaga ctaatgtaaa tacatcgacg tatttaaaga 11880
taggatattt cagtattccc cataaaaatg tcacttcatt gctaaagaat atattcatga 11940
tatatgggaa aattacaaaa gtcattcaat gtcatatttt ctttataata tttagcaaat 12000
aaagtatgga taaaaatgag gatatcaaga aaatggagat atctgatgga cactgtagat 12060
atatccatgt aagagatgta taaactataa agatatcaag acaccccagt tctcaaggtt 12120
tgaactcatc ttcttgagac aagagtgggt tggcatagtg gaaagaacct tccaccttca 12180
atctatgaga ttagggggtt tgaatcatct gggggggntg cttgatatgg gaattacaca 12240
catgtacctg atgtgatcag ggagctgcaa gtgagcaata acacctctac atgtcctcaa 12300
aggaagcctt ccagagaact caggaagaaa agctgctcta gcacctagac atacgatgac 12360
tgcatcatat tcacctgaaa agaatatgca aatcactaaa attgacaaga tcatgaaaca 12420
ataaaatcac ctaaagtcat tgatcagtct gctgtcatat tcacctgaaa agaacatgct 12480
aatcactaga attagacagg accgccaaaa aatagaaaat cgcctaaata attgatcggt 12540
ttgctttaaa cactagcaca ttctgcccaa agaaacctat aataggtaaa aaaatccaac 12600
tccgacctag tctagactct tcacaaaata aaggtattca ccgttagaag tctaagtctt 12660
aacagtacct ttgaggagta caaagagaag cagcaaagtt aattccctta tttgtttagg 12720
aaaagcggat gataatgcaa tcgtcccagt tagcttatta accccttcac tttggacaaa 12780
agagaagaaa ttgaattaat tttaccctca ttctgttgta tgaagcaagt aaacagttca 12840
cctagagagt ggaggttgca agctcttgaa tttattatca acaagatttt tctttttaag 12900
aaaagaaaaa acaaatgaaa ggagaaatgt ttgttttgct acttcacttg tatatgagaa 12960
accacttctt gactacattt tttctggtga tacaaagcta cagttggaat ccaaggaagc 13020
taaggtgatt caataaaata cctgctaatt cttgaagatt atgaactgat ttcttgtgca 13080
gatataactc tttacatgaa atgcctgaac tgcacttgga ttccacaaaa gttctgcatg 13140
ctaagtagag agcctgagag ataatcaaca gtaaaaacac cttaacgaaa taaaggaata 13200
gggactagtt cagagttcta tagttattag gacttctccc tccagacctc aagataattc 13260
tgaggatgaa cattcacagc ttcacgcata tggaacgcca agtccagggg cacacacaaa 13320
ccaggtacca gcttctgtgc agcatccttg tgaattgact ttattctgca gctggcaatg 13380
cagttttgag cattctactc aaggacaaga agacacattc ccataatcat gaaattacat 13440
ataagtttct tattccatgt aataatttga tgtactcaca tcattcatca tgtccatttt 13500
cttcacagag agtgctggtc tcacgattcc actgttaatc attcaaacca atttgcttag 13560
acactaaaaa gatggataca cctcttccgt ataatacaaa gaaaatagaa gctcaatgaa 13620
ggaataaaag atcttgagtc tagggcattg ggtcgactaa agtgtacata tcagttttcc 13680
aactaatggt agtgaaaata tttaaagaaa gaaaaggttc acttatacgc tcagctaaac 13740
tgcttcagtt caatcatgag tacatagtaa attggcagat aatactaagt acaaactaca 13800
ccaacgaggg atttgttaat ggaatatgct taatgtgatg ctaaagacaa attggattca 13860
caaggaaagc aagttaaaaa caggatgcaa cagtgaatat cttcccccct tctttacttt 13920
tcttgttgga agtaaaatta tttggactta cttttctttc ggtcagtgat ttaaactaaa 13980
acgcttaaaa tcaaagaaaa atgtatcacc tttttttttt ttacattttt taaaattcga 14040
actcatttcc attataccca aaagcatata tcaagacatc ttcttagcag cttatatata 14100
acatgcttta cactgctaac cttctcctga ctataaagcc accttctttt gctacagttt 14160
ctggatttga tcgagcatct tcagcaatat ttagaagctt taaactttct ttccagcatt 14220
cttctccccg ccacagaagc ttaactgcaa attttgagtt aaatctcaaa aaggaataac 14280
agtaaaaata aattctaaat ctttaagcaa atgttgagag acagtgtaag gaattaattt 14340
gaaggaagaa ctctgaaccc aactagtaaa agcgttcaca acaacctttg ggagagtagg 14400
gatgaaggag tccaccagac attccagatg cacctccacc aacaccaact tcatcatata 14460
tatctatacg taaattcaat tcctcagaac tttgctgcaa aacataaata aaagatgcag 14520
ctgtaagcct atgacaattg aactaaaaag gagcaagtaa cttagcatta tgactcatag 14580
ataaaataag ttgtcaacgg atttaagtta tacaagctca aagatttggt agacagctag 14640
ggtactttaa cttgttgttg caatttactt gtattattta acactataga ctcagataaa 14700
atgaatttgc taaaagaaga aaacaattgt aaaaggatct aaatatactc catccattcc 14760
aatttgtttg gtatagtttg actcgacaca aagactttta aaacttgtgg tcttaaactt 14820
gtggctataa aagtttctta aaatgggaag tttaaaaata attgttttca aatacataaa 14880
tgtatcaatc tttttggaac ggactgataa gaaaatattg tcaagcacat tggaacgaag 14940
ggaatatata aatacactgt aaatattttt tacatggtgc ttaccttatt tcccaggtta 15000
gcaacacact tattatagac agtagcgtgt aattagctaa catataacct caattataaa 15060
taacttaaac ccattgtaaa atctgacttt atgaacagga ttaactattg tgaactcagc 15120
taagaaagtg taacacatac tgcataatac ctgcaacaaa tgccaagcaa cagacagccc 15180
ggcaaatcca gcaccaagaa ctgcatatct gaatataaaa tccaaacaaa acccaattga 15240
gaagagaaaa aaaaaagaaa aaaaaattaa aaagacagtg taatgtacac tctccccatt 15300
ggcttactaa ctaaccggag gggcctttgt gaaacagcag aatagcaacg gacagagaaa 15360
agggaagaag aagaagaaga agacacaatt ttgggagaag aatgtaaaag gccaaaactt 15420
gctgataatt tcattgaaaa tacagctggg ttttggatta taagcaccat tgttaacctc 15480
tagtagaggt attggtaata gtgtctggtt gcaggtttct aaggtttaag aaaacccgtt 15540
aacccgaatt tgtgtttcag catatcgggt tataaaaacg gataattcat ttaagctcct 15600
tgaagtttct aaagattttg atatatcccc tcaacttgta tagatattct ttttacacac 15660
cttttctttt gtcatacgcc ttaagttgaa aattgtttat atgacatact atatttacta 15720
gtccactcaa aaaaaaaaat acatttctat cttttggaaa taatttaatt tcaaaccttt 15780
tattttatct attataaaag gttttataat aacacaaatg ttattgatcc cacaaagctt 15840
ttattcatta aacttttagg atcacaaatt tcaaaagttc ttttttctta ttaaattcta 15900
tgacaattgc tataaaaaaa ctcacacctt aacaccaaag attgtttgtc catctgataa 15960
tctatggatt ttttaattga cctgaatcat ttttggatat gctttccaaa tccatctgaa 16020
ttaagaactc tttttggatt aaggatgaaa ttaaacttta tgatttcatt ttgtactgtg 16080
aagatctctt tgaatgtgaa atgataactt tgctttgaat catctgtatc catataagag 16140
tccatagcaa gttaccaaat attcaaacag taggtgaaat gtaaccataa ttctcttatc 16200
ttttcacgtt gtgttttaca ttgtgaactg ttgagctccg acttccaaat tacagaaaag 16260
aaggtaatct tgataccacg atacaaaatg ttgaagcgaa gagcaaattt ggtactaaac 16320
atttgactct taggtttaga gtttacaaga taaccaaatt acataaatat ccacttctaa 16380
attctgttga aattgcagaa agtgcagaat tcttaagcat tctggagtca cacggataaa 16440
ttacattaga tggctcaaag taactcaaac catttgacac gagtggacgt gcattcctac 16500
cttggacact gcagttatca gtagactaat gcagaggtgt tatcacaaca ctaattccga 16560
aaattaaata tttctgcttg atttgctgaa agcattaaaa tcatcaaatt acatgtgatt 16620
tgatgaccag ttgactggag atagtgtcct tgtgatgtga acttgctgaa agtgctttag 16680
aaggccaagt agagcacatc attaggcttt tcggactatg attctccgtt ctcgtttgta 16740
ctccacttca tccctttgat gcataattat cagcgctctc cttacctgac aattttttag 16800
cacttgcatc aatacaaggt ggcctaggaa tattgttctg gtataattta ggaggcttct 16860
actggtttac tatcaaagaa agtcaatcag atagcaccag aaatacaaat aaatggagaa 16920
actaggtgaa tattgatgac taaatggtat ataagtgaag cagtggaagg actcttacaa 16980
ttgattcatt catgcccatc ctggtcagtt catcaattag ccgtctctct gatatatggc 17040
taccaatacc cattcttctc ttaatttggg cttccgcttg ctattcatcg agaaaaaagt 17100
aacttcatca aaacagtgac tagaaggaca tataactgga atatgagtat tgattgccca 17160
agagtcaaac ctttatctca tgtgccatct caggagtaag atttatatgt tgattgattc 17220
cagatcgtgc tgcatccatt gtggaatttt ggaagagcct aattgcttcc gtgacgtgat 17280
tctcatttgc aatttgggcg ctaaaatcat gataagaaag aggcagatta ttgatcaaag 17340
aactgtttat ataggcgaat cttataaaag gacaaagaaa acagtgaaaa gaaacacatg 17400
gaaaaaagga ggtttcctaa acagtcttaa attgcatagt taatagcagg atgattcaag 17460
tccctgaagc ttgatcctat gcaagagaca aagaaactac ttataatcgt ggttacttac 17520
agtctcattc ttgcaagagc ttcactcaac ctcactatag cctctagttg ccgcacagta 17580
attggtattg ctgctgcctc cccattatca tttgattgcc gcctcatttg ctgcagcaga 17640
taacagaaga agcaaatatc agtgagatga tgtacaacat tttcacagtc aagaaaggtt 17700
ttggtaaaat gttgcagaaa cgggaaatct aagttttgaa caactcccct agtgaatccc 17760
aagtttttca gacggccatt tgcaagaggt atacttttct gttatcatcc taaaacaact 17820
taaacctttt attagaggta tggagcatat aaatgactag aaagttagca aacttcccca 17880
cttgagagca atccaccaga actgcgtact tgaacaaaat aaaccaaaaa gtacccactt 17940
ctaatttcag tttcagtatt tgaaatttct tgatacatcc cataagcact ttttcaataa 18000
ataggttggt gatccagcag actgagcatc aggagcccaa tgatgtaatt acctgcctaa 18060
ttttgacata actctcttgt aacattgagg ctgcagcggg tgatagtcgt ggatggcaat 18120
tggtccgaca atattgtata tacctgcacg aggaactcaa ttgcttcaac atacagacct 18180
tgacaattac aacaatagtg tagtgctcaa cttaaagcca ggttagaaac caacctcttc 18240
aaccaattat actccttaga agttctagtg tcatccctag atgcctcagc agatgcatgg 18300
accttgatga tatggctagc aatactctgt agtgaaaaaa atactcagtg gaagcacaaa 18360
cttaaggaaa tatatatcat ctttagatga catagaaatt tcattgctag catcaagtag 18420
acgcaagaag atagtacaag ggtactacaa ttgagctcac aaggatattt tgaaaattaa 18480
ttacccattt atttgcgtat tcatgcccag catactaagc atactatcta gatgcctagt 18540
agctagatta aaatgaagtc taccatacaa attttcattt cacccacaga cttgggagag 18600
aatctttctc ttaccttgtc ctgactaccc atttattcgt gtattcatgc ccagcatact 18660
aagcatacta cctagatgcc tagtagctat attaaaatga agtctgtacc cacacaaatt 18720
ttcatttcac ccagacttgg gaaagagaat tttttcttac cttgtcctga ctgaacatcc 18780
taatgtcttt cacaatgaat atcaaatcga atcttgaaag aattgttgtc tgcaagtcaa 18840
tgttatcttg tgcagtctgc aatgcaaaca gcacatcaac tcctgttcta ttgccaacac 18900
aagctgcaga aaattgtaaa aacattaaaa caattgaaag gaattatatt gaccttgaga 18960
tcatcatagc gtccagatgg aggattagcc gctgcaagca cggaggttct tgaattaagg 19020
actgttgtta ttcctgcctt agcaatggaa attgtttgct gctccatagc ttcatgaata 19080
gcaaccctag gcaccagtaa gaagctcttt agaagagctc atgatagagt agacaagagt 19140
atgatgttct aactaaaatc tacctatctt ctgccctcat tttgtcaaac tcatctatac 19200
agacaactcc tccatctgcc aagaccatgg ctcctccttc taggtaaaat tcacgctgaa 19260
ttgtttcata aagaaactca tcatttcaag atatattgaa aatgacacat ttatctgaaa 19320
tggcttctag actagggaaa atatggaaac ttacagagct attatccctg atgacagaag 19380
ctgtgagacc agcagctgaa gatcctttgc cagaagtgta tacggctact ggggccgtct 19440
tttccacaaa ttttagaaac taacaggtaa aaataaataa ttcagactct catttgcatt 19500
ggaaataaaa actaggatga gtaacaaaag aaaacttttg aaccaaatgc caacttaaat 19560
ggctccctca tgaagatgaa atttcaatat taacagcaaa ctgccaccat tgtattcagt 19620
gaagtaaaac tgacctgtga tttagcagtt gagggatccc ccaagagtaa tacattgata 19680
tcacctctta atcttacacc atcgggcaag aactgcacaa atagagttag aaataaacca 19740
ataaataaac aaagagcatt taacattgaa ggcaaaatga cataccttcc ttgaccctcc 19800
aaataaaagg catgctacag ctttctttac atcaacatgc ccaaatattg agggagcaat 19860
ctttgagcat atcttttcat aagcatcctt atcggatgca aatttctgaa attcttcttt 19920
ctgcaaaaag gaaggccatg agaactgata catacaggaa aatccaaaca gagtaaaaca 19980
atgaccaaat tggaaactaa tgctgtccaa acagtacagg aacgtcatcg gcgtactatt 20040
agcaaactgt tatatcctct aactgcaagg catattcatt aagtacttga tctgctacaa 20100
agaggtaaac cctcccccca gtccatagct tgaccgacat tacttaatct tccccatcct 20160
ttctccactc tatgttcatg cttctttgca tgtttttcta ctgcgacttg tggagatatg 20220
taggtggaga caattatctg tatgcagtcc actcacttga aagcatgttg ctagctgtag 20280
ttcaaatctc tcaattagca cattctattg ataatttaga aattacctca tctactgtga 20340
agttggctga ccctcgagaa ttggcctcat tcgtttcttc cattccaaca actctaatat 20400
aaggctgcct aacagcaaca gctcctttgt gactgcatcc cagttcagaa catagatccc 20460
ggaagttaaa agaagataac aaagtgacaa cactacaaaa acaattaaag ttcatttatc 20520
acttggtaga ctcttacgat gttgatgaat ttgaagcctg aaaaacactg tagatcccca 20580
ttatagtcag ccttgtacca ggcactattg tttgaacaag atggcgatct atagacagaa 20640
gcatatttct tggaagctct cccgtaggga catcctacaa ttaccccaac agaaaacaca 20700
aatgaaatga gagtatgatt ataaagaaag ccagcagtca agcttctatt ctggaactaa 20760
atgttccctc acctcagggt tttcctgcaa tttgagcgtc tgctggtcaa catacttact 20820
tttatctgga accactaccc atggatcaat aggacatggg tcttccccca cctggaaaaa 20880
atcctaccat tagaatgtca tccaaattac aacctcaaat aaagagtttc aaattattat 20940
tttattccat caaacctgag gaacatgatc acaagaacgt ggtacaatag ctcctccaag 21000
ccctgggcga catggaacga tcttcacatt tttgcagttc ttacatagca aggttacata 21060
agttgctttt gccttggtcc ttgatgcagc aataacgatc ccagatacct tgaccagctt 21120
tgatatatat tgtgcctaaa caagacaaat aggattataa aaataggggg ataagtagat 21180
caattagagc aaaacttaag ataataaaga aaatgaaaaa gttcaaacag aaaactaacc 21240
ccaagggaac gcattgacat tggatcctgc tctgacctta agagtatttg tacttcacca 21300
atctctggct cctccatttc tccactctca ccagctaccc tcgatctcaa actagccaga 21360
acttcagctg ctgcagtttc aaactagata accccgagac catccagtag aggacacaag 21420
aaaaccaaat gttattcagt agtaggttct taaaagcttc cacattaaag aaactacagt 21480
atttcatgca attgaagaca atgatgcact atctaaaaca cactgatctt aagtgtactt 21540
ttcacttaca aaaaggcgta ttagttcaac agtgaataaa ggacacaccc actaccttcg 21600
gttgtaacaa aatacacaca aaaactatgc ctaaatccca aactagttga tgttgaacag 21660
tatatgcccg cttctacaac tattccataa cccaaaaatg caactacagg gacatcccgt 21720
aaaatacata tacatttacc tttttgaaaa ttcaaatttg tttagaaact caacccattt 21780
ggtaagcatg gagtaaatca ggctataaca tacatcagta caacaaccat cattcattca 21840
ttcatttgcc tcaccaaaca taaccctaac tatataaacc tcaaatgcag aaagctatat 21900
acacaaactt caataacatg agccataatt tgcatcaacc gtattgtttt acctaatcaa 21960
cgcaatctta atccatcgta atcattcatt ccagcaaatc cggatataat ttcaagacaa 22020
aaaaacatgt tacaactaag cagagccttg tgtttttagt aaacagttgc tactccctat 22080
acaactacaa aaaatcaagt attctaattg gattaaatta atatcaaatg gatcctttat 22140
gcgtcaacca ttgatgataa acaactacaa gttcaattct ctagtaagct ctatagttca 22200
tcaatcacaa attcacatcc acatatggct aacaatgcca agaaatgtaa ttagtgcata 22260
tttaatattt gtatatcttt tgtagatttc ttaacacata tctaggatct ccaaagctac 22320
tacgttcagc aaaagcttta cctcaccttt gtacatccac ccttgtcaaa caatcatagt 22380
ccaacataac catacatttc aacaaatcca aatgtaatta caaaccaaaa aaagaagaaa 22440
aactaaatat caagggatcc tttatcagtc atttattgaa tgataactaa ctaccaaaaa 22500
acgttaggtg agttatttct atttgcttaa ccatttttta gcagagtata aatacaagtg 22560
acgtgatata cggatttaaa taacggaaag ccctctatta agatctcaag tgcatcagcc 22620
ataaattcac atccacctac ggccaaaaac acagagaaag gtaattaaat cagtttcata 22680
ccagagggag ataatcagca gggttctgac ggaggagttc gggtagggtt tggtctcgct 22740
cgtacgaaag gaggtctgaa aggttaataa ttaggtgagt ttggttctcg agaagtgctt 22800
cngttcttct ctctttctct ctctgtttaa ctcactttca gtttcagatc tctctctctt 22860
tgtggcttca gcttctgact ttgcggaggg ttttagaggg agtatgattt tggcgggaac 22920
cacttggcgg gaaaatatgc acgtgagtag tgcgtgcgtg taaagagggg gctcctgttc 22980
aaatatataa aacttgcgag tcataaagaa aaatagtgaa caatacacat tgaatgagtg 23040
aaaatcatct ccgcctccca actttttttt ttttatacaa tatacattct tccccctcct 23100
aacttacgta atatttattt tgcccgttga catttccaat tcgcattgta tgtaatactt 23160
tttaaaaaaa ttatatataa tatttatttt accctagatg atattactta ttatttagat 23220
tattttatat tttattatga attgatatga gttcaataaa actaaaaata caatagttct 23280
tttataaatt ttgttactgt atctaccgct aatttttatg attattattt taatattatg 23340
cgcgctacgt atatatattt aagttctaca ttctcttact gatgaaatat tttctaaatg 23400
taacttaaat ttctctgaaa gtataaatag ataatcacta aaaatgcatt atcaaatcta 23460
tctctattta ttttttgtat tacctgcatt aagtgtatgt aagggttgac aaacgggcgg 23520
gacggggcgg atatgtgtgg gtcgaaaata ggtatgcaaa aacgaataaa ctatttgacc 23580
catctatatt taacatggat agaaaatagg ttaatcgatg gataatatga atacttgtgt 23640
tattcatgac ttcttgaatg tgatcacttt tggggaaatt tctagtcttc caaatttaag 23700
ggactcccga tttgagtatt tgcaaatgta acacattggt tatccgttga gtatttattt 23760
tctaaatgga taatatagat tttatacata tttgattcat ttttaaaaag ttcattatcc 23820
aacctatttt tagtggataa tatggatgga taatttgctt ttttatccat ttgtatgtat 23880
aaatgtgatg acccgatatg tcatttttaa ttttaacctt tatttctgta ttccgagacc 23940
ttaaatagct ccgtttagcc ttcctcgatt ttgcgtgcac tccatatctc ttttctgaaa 24000
aaatttaatg tgaaaaacta aagaaaatgt gaaattctgt cttacaaact cattgagttg 24060
acttcggtca acgttttgtg taaatatacc cggatcagta ttttgacggt cctgattagt 24120
ccgtatcgtt atttgggact tgggcatatg cccggaatcg aattcagaag tccctagctt 24180
gatttaacgc catttgtcga aaactataaa tttaaaggtt taaagaattc ctaagtttga 24240
ccgtaaattg actttgttca tgtcgggttc ggattatgat tccgagagtt agagtagctc 24300
tattatatca tttggtactt acatgcaaaa tttgagatta ttctgaattg atttgacatg 24360
ttcccgcgcg agttatagaa ttgaaaattc cataaattca ttaagttcga atcgaggtgt 24420
gatttgtagt tttgacgttg tttgatgtga tctaagacct caagtaagtc cgtgttatat 24480
tacgggacat gttggaatat tcagacgggg acccgagggg ctcagatgag tttcggatcg 24540
tttggatcat tcttggttaa gttgggcagg tctattgtgg tgtgtccgca tctacgaggg 24600
ctggtcccag atgcgagccc gcagatgcgg cacattgatc gcagaagggg aaacatacta 24660
ggcttgggga ccatcgcata tgcggagaaa tgaagtgcac ctgcgtgcgc ttcgaagcaa 24720
gaaactggcg cagtagcggc cttatatatg cgcgtttact tgtcgcacct gcaatgccgc 24780
aggagcggat agttttctgc aagtgcgaga gccatttctc caatgacctt ccgcagaaag 24840
cggaacttct ctcgcacaag cgacgccgca tatgcggcca atatgtcgca ggggcgaaca 24900
tgtctcgaca gaaacacata tttcggggtt tggtattttt atcatttttg agtttgaagc 24960
ctcggctttg agcgatttca gagggatttt tcacgagtat gaggtgggta agtgttcttt 25020
atccgaaatt gattatattt cgtgatttca taactatttt atatcattag tgtcacgacc 25080
caaactccct atgtataaca tcgtgatgac acctagtctc tacgactagg taagcctaac 25140
aaaatgcgaa aaataacaaa acgaaagtaa aatttggcaa ctaacaacac tggataattg 25200
aataactagt aacaatatcg ctcgacatgt acaataacca atactctata aatacacagt 25260
cttcccaaaa tctggaacat cgtaagtcac aagctacaga agaaaaatag catttctata 25320
cagcagagtc taataaaagg aatacaggaa gtgtttgaca taggggatga ggtaccgcct 25380
tgtagtgtca aaagtaaatg tgcagggaga actcatgagg aaccgcttcg tagtctcaaa 25440
agtaaatgtg cagggagaac tcatgaggaa ccgccacgta gtctcaaaag taattttaca 25500
gggagaactc ccaaggaacc gtctcgtagt ctcaaaagta aacacacaac tcaaactgat 25560
aaatacaaca gttaacaaca agatttctat agttaatact gataaagaac aaggaaaaac 25620
agaaaatcaa ctaggcatgc ttcacagagt tcaaataagc agttaaagat tgtagacatg 25680
cgatattaga ctaaacagga taactacaca tattggtata acgcaaataa gaatgaaaag 25740
caaattacta cttagaaaat ggtataaccc aaattaaaag gaaaacaggt tgctacttag 25800
taaaatcagg ttttacaaca aatagctcat atacgtactc gtcacctcgc gtacatggcg 25860
ctcacatatc acaacagtac caaatcctaa ggggatttcc cccgcacaag gttaggcaag 25920
ccacttacct cgcaccaagc tcaatcaatc agtaagaatg ccctttcctc aattatccga 25980
ctctgaatgg cccaattcta gccaaaacaa tttcatacca tgaatacaac tataatagac 26040
taatttaatt tatgaaatca agactttaac aagaatttcg aaaatcgccc taaaaagcct 26100
ccccgggccc acatttcgaa atcgggtaaa agtcaaaaaa tatgaacacc cattcactca 26160
cgagtccact cgtaccaaaa ttatccaaat atgatatcaa aatatcaatc aaaacccaaa 26220
atcttagtgg aaaaacttct tcccattttc cctaaatttt ccacccaaat tcgaaattaa 26280
aagatgaaat tagtgataga ttagtgggat ataaacaaaa tcaagggaaa aatcgttacc 26340
caattgatgt ctctgaaaat ccctaaaaat ctcgcccaaa tccgagctct caaactcaag 26400
ttttgataaa aatatccaac cctcgatttt ggaaacttta acaggcattt ccttagcttc 26460
ttcgcgaacg cgaccacacc ctcgcgttcg cgaagcacaa atttacttcg gcccaaaatc 26520
ttccattgca aacgcgatgt ccttgtcgcg aatgcgaaga ccactcagct cgaccctaca 26580
cgaatgcggg accaacgtcg cgaacgcgta ggcaaaaagg gcatggggac ccagttggcc 26640
aatacctcca cgcgaacgcg ggacctccgt cgcgaacgcg tagaccaagt acctcagtgc 26700
ttcgcgaacg cgagaccttc atcgcgaacg cgaagcacaa aaattttgcc tgcctccagt 26760
tcctcttcga gaacgcgaga ctcccctcgc gaacgcgaag aaggaaacaa gaactaaaga 26820
aaaccaaaaa tcagcaatct ctcctaagtc caaaatgatc cgttaaccac ccgaaatcaa 26880
cacgaggccc ccgagacctc aaccaaatat acctacaagt tctaaaacac tatacgaact 26940
tagtcgaacc ttcaaatcac atcaaacaac gctaaaaaca cgaatcaccc tccaattcac 27000
acttaatgaa ctttgaaact tcaacttcta caactgatgc cgaaacatat caaatcacgt 27060
tcgattaacc ttaaattttg cacacaggtc ataattgaca ttacggacct actccaactt 27120
ccggaatcgg aatccgaccc cgatatcaaa aagtccacta ccggtcaaaa tctccaaaaa 27180
ttcgactttc gccaattcaa cccaaaatca gctacatacc tccaaaacac aatccagaca 27240
cgctcctaag ttcaaaatca cccaacggag ctaacggaac cgacgaaact tcatttcaga 27300
gtcgtcttca catagtccga ctacggtcaa aatgctaaga cttaagcttc cattttaggg 27360
actaagtatc ccaaaacact ccgaaaccaa aaacggaacc tcccaaatca cataagcata 27420
aaaagatacg gggaatgcag taaatagggg atctgggcta atacactcaa aacgactggt 27480
tgggtcgtta caattaaatg gaagaaatga gaatttttgt aaaatctttc aagaatttaa 27540
aatgaggatt tgaagggcga tccgatatca gaatttgtta attttggtat ggttggactc 27600
gtatcggaac gagtgttcgg gctttgtgaa ttttattagg tttcgagatg cgggcccggg 27660
ggagggggaa tggggttgac tttcgttaaa tttttcgaaa atgatctaaa ttggacctct 27720
ttaaaatttg tgagtagttt ctaaagctta atttgaattg ttggccgatt aattgctagg 27780
tttggttggt ttggaggctt gttcaaaagg caaggccgtg gttgagtgat tgcttgaatt 27840
gtggagcgag gtaagtgttg tggttaacct tgacttgagg gattatgact tgtttgccga 27900
tttgctacat aattaacgtg tgggtacaac gtatatacga ggtgacgagc atttatgtat 27960
tgttgtggga taaagcatgc gggtgaaatt tgtttccttg tgatttattg cctttttatt 28020
tatgatatcc atgcctaggt tacattatta cttaattgat catttctccc attattattg 28080
cttaattagt aatggtggag tattttggaa gttgaggttt ggtatcgtgg catcatattt 28140
gacataaaac atattcacta tgctatttta tcttccgaat ttatattatt tttactaagg 28200
gagagtgtta aagcacgaag ggtgatgccg tgccatcttt ataccgtatg ttgtccgtct 28260
ttattggttg ataatttatt tggctatctt gtgatgtcat acctgttgca gttatcgtat 28320
ctctttcccc tttggcatgt cccttcccaa ttatacattg ttaaatctct attttgttgc 28380
tgtctcgtac atatatatat atatatatat atatatatat atatatgttt gtacaggttn 28440
tgtcctatca tagcctcgtc actacctcgt caaggttagg ctcgacactt acggggtaca 28500
ttgggtcggt tgtactcata ttacactctc cacttcttgt gcagattttg gtactggacc 28560
taactatacg tgaggtgcgc caactcgaat tatcgcatac ggaggcttga ggtagatata 28620
ttgacgtgcg caaaccttga agtccccttc taccttatcc tagctgttta tttcatttca 28680
gacagtttta ctttcattca gaccattatt tatattattc tagtcgttcg tgcacttgtc 28740
acaccaattc taggatggta tttagacatc attgttaatt tttggtttac tcattctatt 28800
ctagatttat ttcgattata ttggtttctt tattattatt caatttgaag tgttaaaaat 28860
ggctaaaatt attctaacgt tggcttgcct aacaagtaaa atgttaggcg ccatcacatc 28920
acgttattct aacgttggct tgcttagaat tgtattttct actattatac cttgaaagaa 28980
aaagaagtgc ctatcatttt cttgttaaat taacgttata tcataagaaa caattaagta 29040
aaactgataa tagaaaatga cagacttggt acaaattagc aagttcctac atactctgta 29100
aggtaatctt ttccctcatt tacactcaac ggcaatagca caggaatttc aagtagcagg 29160
catctgtgag actgtgactg gtttaatcaa gaagaaagcg aacaaaaaaa tgaagaaaaa 29220
agagaattga aataaaaaca ccaagaatgg gatacttttt ttcccaccaa gaatgggatg 29280
acctccaaaa aatggcaggc ctgatatgat ttcaatgcct aaagcaattt gccaagtaca 29340
actaattaca tcatttagca cctattctat ttgcagcgac accaggagtg agtgagaaag 29400
acccctttat cacctggtta atatacaaat tatatacctg tatacatata ggatagacat 29460
acagccgtat tatcgttgcg ctaaagatca tacatacatt ttttgttact tttaattaag 29520
tcagtattca gagggtaagc actctcagtt attgaacata tatccttcct gcttcaagaa 29580
ccaaagtgcc ccttccgctg catcctcagc tgcatctttc tttttcgccc gagnaggtag 29640
gtgccatagg ctataaaatg tcaaggattt tcagtgcaca gaaataatca agaaattgag 29700
gatgatgtta gtggttttta ccttttctgg ttagatcaga tgacaaactt aaagacatgg 29760
attcccaagg acagcattaa accacataac cagcaaggat tttctttatg ttaataggtt 29820
ccaagaatta aacttgagaa ctacaagtgc aaaataaaaa tttaaacaat caaatagtgc 29880
agaaattaac cagatacaaa gtatgattgc atatatcctc ccatctcaag ctgaactttt 29940
cttctatatg gtgcattgat ttctacttgg tagattcccc acatcggttg tggatggagt 30000
aattggtctc cttatatggt cttggccaat cttcaccttt tgagctaact tttcgggttg 30060
aattaggctc aaggtccatt atctttgtaa caccccgtac atttggacta ggtgtggata 30120
tgttaaatgg gtattaattt gatattttag acatatgaag tcccatcagg atgagtatca 30180
gtggaaatag ttgttttgga atcaagatgg agagtgaggt gcataagatt caataaaatc 30240
gactaagttt atggaaggta ctgccttcta gaagaatgtc gtaaatttat agccctttga 30300
aatagctttc caacgatata ttatggagcc caaacgtatc tctgtgcaaa acgttacgtg 30360
tgttttacag agcagtgcac aatatgcgcg gccaggtgcg cgcccagagg gtcacgtgcg 30420
cggccgcgca cttgaggcag tgctactacc attttgcgca gtcaggcctt caggtgcgta 30480
cctggggggt catttttaaa gccctacttc gtccccccca ccccaaaaca caaaaatttg 30540
ctctagaaag ggaagctctc aagaagctct cccaaggtcc ctccaccatc caaggtaagt 30600
tcgaatggtg attctaagtt gatttcaatt cctcaatacc ttattaacat gggtaaaccc 30660
tccaaattgt tagatattcg attggggcat cattgttgag agaaggaacc ctagaactcg 30720
aattcaagag gattgaactt caaaaaggta atgtcttcac tctctaattg attataccat 30780
tgattataga ctctatgttc atgagatatg agttgatgag tttaatagaa aagcatgaac 30840
ggttataggt ttgggttatt gattgttgat tattggttaa agggtgttgt ttatcttacg 30900
agtgatgaag aatggtattg attataacaa tttgagattt taatattatc taggagcaaa 30960
agaatgggtt gttgggtgta gaaacatcat taataaggac tatgaagctt tatgcctacc 31020
aagtgtttga taaaaggcct aagcggccaa aacataagta ttattgctaa tatggaatcc 31080
ctttgacttg tattgatata gattaaagtt gaaagggttg gccgaatgtt gtattacgct 31140
caagagaagg aagttaaggt atgcgaggct aactctctac gtttgggaat gttaatgatt 31200
ctccctacgt ctcattctta tgactattac aaatttcctc agaaagtaat tatgcctcag 31260
ttccatgaat agttgtagac gttactaatt gcctcagaaa tatagttaag cctagttccc 31320
tgaataattg cagaacttct attctctagc ttcataattc gttcatgact ttcattccga 31380
acgttgtggg cttagtgcgt aatcaatata gacttgtgtt aactcccatg agtctcagcc 31440
taaattacca gcatgccata aatagttgaa acataagtcc tcataatcag ttcatgaata 31500
catgtcttag ttcaattcta ttcatcattc aagtatcatg taactcaata tcgttcagta 31560
tcatgtatta cagtacgatt ctcagttcat gtttttaaat ccctgaatgt tgaacacctg 31620
tatttgggcc tgaggccgta gtttatgctt tatgcatgtt tgggcctgag gccgtagttg 31680
atgctttata catttttggg cctgaggccg tagcttgtgc acatatatat tgggctcgag 31740
gccgtagttt attcagataa acaggttgtt catcattcag aagagggaat attcatatcc 31800
ttacttcctt tgttcagtta tcatttcagt tatcaattct cagttatcag cttagtttca 31860
gtttcagcat ttataattct ttctttcagt tgctttacat accagtgcaa ttcaaatgta 31920
ctcacgtccc ttttgcccgg ggcctgcatc tcacgataca ggtaatgatc tacaggttga 31980
tgattcagag cgctaggatt ctcgtaccag ctatttggtg atccctagtt ctttcggggc 32040
attatcatca ctttgcaatc tttcagtatt tatagatagt cagtattttc agtacttcat 32100
tagaggcttc atagactaga gtaacagtta gacagagtca cacacttttc atgttaagca 32160
atgttggcta caaatacgtt tcagatttat gttagtattt ccgcacttga tttatatcat 32220
tcagactttc agtatatcat catgtgttaa tttatcttcc gtattcagta tgggcccata 32280
ttatatttac actccaaatg tccagttctg agcttgtgtg tcggtgtgtg tgcgtaggga 32340
gggggtgtta gagacctaca tcagttgtgg atgagactct tggtctcctt acatggtctt 32400
ggaaaatcct tacctcatga gctaactatt ggggttgagt taggcccaag ttccatttct 32460
tatcggtact tgttggaggc ataagtttcc taggcttcat tcatgaatgt caaataagag 32520
tggcaagtgg gccgggccca tgggctaagt gggctaaacg gactgggact gttaggcctg 32580
ctagaggtgg accggttctt agctaggaac cgttaggacc gggcccgttt gacccgccaa 32640
gagaccggga ccggatcggt cccttggcgg gtccaacgaa tattttattt ttaaaaaaag 32700
agccgtttgt tgtttgaaaa aaaagagctg ttgagggttt aaaaaatagc catttaactc 32760
ccccaactta gttttaaccc caaacttttt attattacac tttttcccta ttttctacta 32820
taaataccct ctcattcttt cattttctta caaaatcaat atcaatctat ctaaatctct 32880
ctctaatttt gttctatatt tgctacaatt gtttacttta tcaaaacaaa atagtgaaaa 32940
aattgtgagg ttgctactat tacttacttt attccaaaaa atagtaaaac aatattaagg 33000
ttgttacaat ttggttctag tagtaattat ttttcacaac taaatgagct tgaagtttat 33060
atgtcgcagc aacttgagga agtgaatccc gatggcacct ttaatatttt gcaatggtgg 33120
aaggacaaag aaaatacttt tcagttcttt caaggatgac ccgagacatt ttaactattc 33180
aagcttcaat cgtgnacctt agatattttt ttaacatctt tttgtctcta atttttattt 33240
aacttttttt aaaaaaattg ctgcttagcc gttggaccca tttagcccgt tgggaccacg 33300
accccagccc gtttagcccg ggaccatgag ctcgtgagct cggtccctgg ccggttccta 33360
caaaaagcac gtttagctcg ggaccgttta gcctgtttat ttaagacccg ggaccggccc 33420
acttgtcacc cctaatgtca aatgttattt tccagtacaa cttgtcattt tacaattttg 33480
ggccatttca tgaaactcga tattttacaa tgctgaataa ttactttgag atgagtaatt 33540
agttaatgca ttttgttcat tacggtttag tttacgtttt catgattgca ggaatctgct 33600
caaaattctg gaatgaaaat aaaagctact ttttactagt nctctcattc tttcattttc 33660
ttacaaaatc aatatcaatc tatctaaatc tctctctaat tttgttctat atttgctaca 33720
attgtttact ttatcaaaac aaaatagtga aaaaattgtg aggttgctac tattacttac 33780
tttattccaa aaaatagtaa aacaatatta aggttgttac aatttggttc tagtagtaat 33840
tatttttcac aactaaatga gcttgaagtt tatatgtcgc agcaacttga ggaagtgaat 33900
cccgatggca cctttaatat tttgcaatgg tggaaggaca aagaaaatac ttttcagttc 33960
tttcaaggat gacccgagac attttaacta ttcaagcttc aatcgtggca tcagagagcg 34020
ctttcagtca agcaagactt caaatctgtg attatagagc gtctatgagg gagaacttgg 34080
aaaatcagta cttttcagag attggatccg ttcggaaaga agaaattttg gacttggctg 34140
aattacaacc agaggtagac gaagcttacg aagaaatgct agctgaactt gctgaggatg 34200
ctgcttcgcc cgacaatgga agcggcgatg accaagctac ttttccgcca ccacctacgg 34260
aacttcctcc gaaccttgaa ggatttatga agtttgtaaa aaatatcatg taacttgtat 34320
gaacaaaaaa tagtatgtat tatgtaactt gtattttggc acatcttgat tggttccttt 34380
ttcttctcaa tggtgttatn catactcttt caagtggctt ggccctgtct ccttgcaaca 34440
ttcaaatcta ggaggtttcc agcagttggc agcacaaact tcatgcaaaa ttgactttgc 34500
cgatccattt attgcaccac ctgaattatt ttggagtaag agaatgacaa catggataaa 34560
taagcagata gagatccttg ttattgatac ctgtagcttt tgaatctgaa ttagaaccat 34620
taggcatgat ggtctgctca gaattgcatt gtacagctgc ctctggggcc aactttctcg 34680
caggctttaa cttgaaattg caatttcttg caagttcttc actaataggg aatactatca 34740
agtcacgatc actttcagat gcttcgttct tctccacgtc attgcaccta gcagtaagaa 34800
cacagggtgt ttcatcatat cctatcagtt tagcttccat ctttttagct gtttttacca 34860
cttgctccag tgatttagac ttgcgcctat agccttgagc ctgcacattg gaagacatta 34920
ctgaactgca aaatagctat ataagagaag tccgataagg gaggtactaa gattggaata 34980
ctaaaatgga aatcaaactg cagaaacaat gataaaatca gataagaaga gctgacatct 35040
atagtaacga cgcctgatca gcatgcaact gctgagagaa gcaaagaaca aaagtagcag 35100
aagtgttgtc actgtctcac tgaccagaga gacatttgaa gaagagaagt aaaaatagaa 35160
ggcaaaagga acatcgaagc atacttgata ttatgtaaac cagtcaataa attatttgcc 35220
aaaactaggt aatttatcaa ctaaagtgag aaacttgcga agttctgcga gaaatgttat 35280
aggttttagt gataaatcat tatctttcct tatgcataga gatgcatttc tctactctga 35340
atgctcacaa ggcaatgtaa actgatccat gaaacttgtc cccatttccc attacgacct 35400
tgaacattgt gagggtccta gtacccccct aaaaaacttt caagtggaat taatgccccc 35460
tttctcagtc acctggcata gaaagtgttc atcattctct ctttaagagt gtgagggacc 35520
aaaaagaagt tttataattt gtttttgcaa gataattttt tgttaaatgc atggcgaagg 35580
tacatagttg ctcctgaact atgagaaatg gtttactttt ataagaagtt ggggttgaaa 35640
ctacccctgt tgttaccaaa atggtctaca cttgcccttt tctactaatg gaaaatgatt 35700
agcaccacaa atcgccacgt gttgaagctt aaaattaaac cacaataatt gatttgaatt 35760
aaaggacatg aatgatccat ttcacatagt ttaggggtaa aatgacaaaa agtttttaaa 35820
atgaaattga cacgtggaag caagaattgc atgctaagca cttcctttcc ttaaaacagg 35880
ggttggccaa caaagggggt actaatacca cttagaagtt gttcagggag taatacgacc 35940
cctgcaaagt ttaaggttgt aaggggaaat ttgggacaag tttgaggggt ccttatgtat 36000
tatccaaaat tatatacatc agcttatgcc ttgttttatt cggnagtcac taagtgcttg 36060
aacagcctct tttgagctct gtatctgatg actacctact gtcataatcc tttaggcaag 36120
actcatcact agtacagagc gtgaatgcaa tgagaacatt ctctgcaact tgatccacta 36180
caaagaccaa atataacttt gtaacaccac ggtggtatca cataaatgaa gaaagctgtg 36240
agagcaagca gttcagtgat ctcaatcatg ctcctccagc aaaaccgctg aagagattat 36300
caacataaag cagcaacctg atgttggggt gagtaaagac ttgaatgatg gaatcaacaa 36360
gaaagtctgt gctacaagaa cagtgatgtc acgagaagaa atcaatttga gcaataagcc 36420
accaaaatcg atgttttcgt actattttat tgtatgagga gaaagttcgt tcataacgaa 36480
gaagagcaca acagcaggat tacaatattt tggagctaaa aataattatt aaagttacag 36540
agatctcaaa attctttaag gattagtcaa cagaacacca tgggagaggc ctgcaaccat 36600
gcaccaaatt attgcaaaaa aaaccactct ttctcataca tggcatttga aagaaggtga 36660
tcatgacatg gtctaggttt gcacccaaat tcagcatagt acagccacca aagcccctca 36720
ctgtaggacc ttagcattct agctagttgc tacaaccaat acccaaatac cctaaggtta 36780
aaatctcact aacaatccac gcagcatcaa aggttttcct gagcaagcca agtgattcaa 36840
gtcatcagtg acttggcgag tacttggtat gaaaggaaaa tgttttccac ggaaaatttt 36900
tcctgaaaaa taagtggttt tcttacttat tttctggtat ttcgttagta agcaaaaaat 36960
attatctcaa gagcatttat aacctagaca gacattatgg gggtggtttt ttttttgggt 37020
ggtgnacata caggaaaaga gctccaacaa gaagaaataa cagcacagga actagtaaga 37080
tgcataccgt caagcttgaa agtacttgct gggcagccat tcttttggca gcttttttat 37140
tgatattggg agcagaagcc gcttcagaaa cattcttccc actcacattg gcctcaacta 37200
gatatttgct atcttttttt gaaaccagga actttagatg ccagccatga aactggcaaa 37260
gttcatggag ttctcttttt ggattatgct gcaacctggt aaagctcatg acgggcttta 37320
agaaggagag cattatatgc caagcacggt tcaagtcaaa ccctgtgtca agcaggattg 37380
cacccataca agactccacc aggtcgccaa gggcctgaac caaccagtaa acatgagagc 37440
acaatgagga ttcatctttc aaaggttcag caaaaaaaat gattgaacaa ttttctttac 37500
tgctcagggg agaggggaga agcaatcaac cccggtatta cttgatatat acaaatgctt 37560
cagcaaaaga aatgattgaa caattttcct tactgctcag gagagaagca atcaacccca 37620
gtattatttg atatatacaa atgcttccat gtataccatc agaacccaat ttacttgact 37680
aacattcctt ttcagtagcc ctaatctctt tgctttttta ctggacaaca aactctcttt 37740
taaacaagga ggtgcaatga tgcaagagac aacttaagaa agaacatgaa aacatctgct 37800
tttagtaagt ttgtggccca acctttcaag gatgcttatg gtataggttc aaatcttatt 37860
ttaggttacg ttacctgcta accatgtcta ttaccctatc aatatcttta tcttgatagg 37920
gttaaatttt ttaacctagg atttgcagtt catcgattta taataaatag cacattattt 37980
agttaacgtc acctgaataa ttcaatgatt ctcattttct ttggagccct acccatccaa 38040
gaagctaaaa tgcagaagtt cccatattgt ttagtaggaa tgcgggtaaa catcttgcat 38100
gtagtacata gaatttcata atgttctaca aatagaggca agaacaactc catattgttc 38160
tgtacgtagc ccatggaaca actccatatt cttttatatt aatggttgga aaatgcctat 38220
ggctttggcg aatcttctgt ggcttctcgg tgctttatgc attacattat caggactctt 38280
catttgtcca gatgcacacc tgtcaattgg gcacggcatg ggcattgtac ctcgtaagaa 38340
tccttccatg taaggttaag gtatatctaa aattgcatgc acctgagtta gataaaaaca 38400
tatatctgat gctcatgttc aagtacctga ctctgattgc ttcttcttct atttctcact 38460
attcttttac tccaatagac tcgcaatacc aaggtattct tcatctttct tcttaatgct 38520
ttagcaaaga tactgtcatg aactattaac aggaccagag catccctgaa ttacaatgct 38580
agagcccaaa gcctccactg ctttacccat taatgaacta ttaacatcca ccttttctcc 38640
tcactatttc agctctaaat atactgctgc aaggttaggc aataaagctc ctttctcacc 38700
tacctaggaa aagaaaaaaa gactatgctc aattctaaac tggttgcagt cgactgtatg 38760
aatcctttat atatcattcc gctctagttg ggtgcattca ttcaaatact caataattta 38820
tcttttatta caacttacag attctctaaa actagaggtt cactaaacct taccctacac 38880
gggtgtacaa atttttacac aaactaaaag acactggcaa acattggagt caaattaggt 38940
ataccaacac aactaagatt tatttccaac tagttggtct tgcatatatc aaaagctact 39000
acacctaatt tatgtttttt tctagaatgg actttaggac tttccctact ctagcacagg 39060
atctttattg ctggtaagcc tcgataaaac gctaattgtt cagtcgaggc ttaccagcaa 39120
taacaatcct gtgggaatgc agcctcaacc tgctggaaaa gcatttaact ggagtcgtct 39180
attcctgatc caacaaagga aagaagcctt gatcccaata ctagctgtgg attggaatgt 39240
tattttatcc aactgactct aatcatgatt attactctaa acaactggat tggattttcc 39300
aactctcttt ataaatagac tgctttcaat ttcacttgcc ctagaacctc tttttattga 39360
tattgatcta gaatcagctt atcctagttt ctttattatt caacaccaga agctattgtc 39420
acgacttgaa cacatgacct tcataaaaga aatgaaataa taaatttgtt ttccaggcaa 39480
gatttggtga tttgggacat tccaggtaaa aaggtagtgc atgtcagaat atagtccatt 39540
tagtaatgtc agactatttt agcttagcta ggttcgtctt ttgagacttc tttcagttac 39600
atcgctattc tggcaaggcc aatgtcagaa agctggagca ggaatagagt ttaggaccta 39660
aactggaaaa caatcaactc ctgtgtgcaa caatatcaaa caattttgcg agaaataaga 39720
gaaaaggaga atgacagaga catacgcctt acacctgaaa cctttcacat cactttacaa 39780
agtacattct tacccttatt tgtggagaca atgtcgtttt gcctaataca caatctgctc 39840
ctctagcaat aatatcaaat gatttgaaga ctcaaatgtc ttatacctgg attcttttat 39900
aggaaaactt acaatgacaa ttcttactgt tagtttacag atatgtatag tgtgattgtc 39960
ccacattgga agaggagtaa tatctccttg tagtgtatcg ctataaatag ggacctcttg 40020
tattgtattt tttttttata accgtggtgt ccgggccagc ttgcgtgcac ctcgactaat 40080
tccacgggat acctgccacc tcccactagc aacaggtacc aggtaactct atccaccaag 40140
gcttggatag atgggaagaa atcacctagt atttgcttcc gctgggattt gaacctgaga 40200
cctcatggtt ctcacccact tcattgacca ctaggccaca cctttgggtt tgtattgtat 40260
ttatcatcca atatcaataa catattttct cccgtgcctt ctcacatggt atcagagcat 40320
tagtgagaaa agatcgctgt gcgtcattcc aacgttaacc gggaagaaag aacttagtca 40380
tcgtgcaatt tttccggtga cctaaggctt gtctaagtga aagtcacttt ctgtcggtgt 40440
tgtgctaaaa ccaacatcac cacgaggtag atcaccctcc gacgaccaac ccctgaaatt 40500
ttatccggca aaaaaggcgc cacgctcctc cacgcgccgg caacaacaac ttttccggcg 40560
agggttccgg ccactttccg gccatttttt tgcgaagctt cttcaggaca gtgtgctctc 40620
ctcaaaattc cgagcttacc catctaattc aaatcaaatt ccgatcactt ttatattttt 40680
ccggcgtgaa cagtgacctt tgcggccatt ttttgaaaac atttcttcag gacagcttgc 40740
tcgcaaagga attccgagtc tatccatcat ggtttcgaca aattccgaca actttggaat 40800
tttctggcga gctacagtgt ttccggcaaa gaacattgtt ctgttttcct gctgtaaaca 40860
gtgtttttca agctatttct tcagttttct aacaggagtt acttatttcc actatttcaa 40920
gttaatccta ctactacaaa ttgtagcgac atgggaaccg atgctttgaa tagtcggatg 40980
gtttctttag cagagtatat tgagttcctt cagtataaag catgtaagca gacatcttct 41040
gagatagctt ctgttgttca aacaggtaat agcgtgactt gtttctccca atcttcatcc 41100
tctgagtctt gggtcattga ttcaggtgca tcagatcata tttctggtaa caaatctctt 41160
ttcactacta tttcgtattc tcaatctctt ccaaaagtca caatggccaa tgggtctcaa 41220
accatggcaa ctgcaatagg tcaagcaagc ccacttcctt ccttaccttt agattcagtc 41280
ctttatgttc ccaatagtcc ttttaatctc atagctgtta gtcgcttagc caaatcactt 41340
aaatgcgctg ttttatttct tgatgaccat gtttttatac aggaacgtag tatagggcgg 41400
atcattggta ccgggcgtga atcaaacgga ctttattacc ttatccttgc taaatcacat 41460
ggactcacat cttgttttcc ttctacaact tgttctgtta ctgattcacc aaatttatta 41520
cataaacggt tgggacatcc cattttgtca aaacttcaga aaatggtatc tggtttatct 41580
cacttgtcag ctctagagtg tgagtcatgt cagctcggta agcatacccg ctcccatttc 41640
cctcggcgtc ttgataatcg agcagagtca ccttttactt tagtccattc agatgtttgg 41700
ggtcctagtc gggtcagttc caccttggga ttccgctact ttgtcagttt cattgatgat 41760
tattccaggt gcacttggat atttttgata aaaaatcgat ctgagttgtt ttctattttc 41820
cagaccttcc acgctgaaat tcaaaatcaa tttggggttt ctattcgcac atttcgtagt 41880
gataatgccc gagagtattt gtcttcccca tttcagcagt ttatgaaatc tcatgggatt 41940
attcatcaaa catcttgtcc gtactcatct caacaaaatg gggtagctga aagaaagaat 42000
agacatctta ttgaaactgc tcatacctta ctcatacaat ctcatgctcc attgcgtttt 42060
tgggggatgc agttcttaca tcttgctatc ttattaatcg tatgtcatct tcanagctcc 42120
tcgtgctctt aagtgcgtat ttctgggttt ctcgagaaca caaaaggagt atcgatgcta 42180
ctctcatgac ctccaacggt accttatgtc cgttgatgtt accttctttg aaacccaatc 42240
atacttcaca ggttcaagtc atcacgtaga tatttctgag gtactaccag tttcatcttt 42300
tggagattca gtcactccag ctctaccacc tacagctcca gttgtagctc caccacctat 42360
agctccagtt cctccacata atccagttca accttctgca gcttcaccac tcttgactta 42420
tcatcgtcgt ctacttccag catcaggccc agatgattca cgccccgcat aagattctgc 42480
acctactgca gacttgtctc ctcttagtca accaattgca ctccgcaaag gtgtacgatc 42540
cacacttaat cctaatcccc actatgtcgg tttaagttat catcgtctgt cgtcacctca 42600
ttatgctttt atatcttctt tgtccactgt ttctatccct aagtctacag gtgaggcact 42660
atctcatcca ggaaggcgac atgctatgat tgacgagatg tctgctttac atgccagtga 42720
cacttgggag cttgttcctc ttcctgcaag taagtctact gttggttgtc gttgggttta 42780
tgcagtcaaa gtcggtccgg atggccaggt tgatcggctt aaggctcgtc ttgttgcaaa 42840
aggatatact cagatttttg ggcttgatta tagtgatact ttctctcccg tggctaaagt 42900
agcatctgtt cgtctctttt tgtccatcca tggctgttgt acgtcattgg tctctttatc 42960
agttagacat taagaatgct tttctccacg gtgatcttga ggaataagtt tatatggagc 43020
aaccacctgg ttttattgct cagggggagt ttaatggttg tgtgtgcaga ttgcgcaggt 43080
cactatatgg tttgaaacag tcccctcgag cttggtttgg taagttcagc acaattattc 43140
aggagttcgg catggctcat agtgaggctg atcactctgt gttttatcgg cattccgctt 43200
ctaatctgtg tatttatcta gtggtttatg ttgatgatat tgttattact gataatgatc 43260
aggatggtat tactaatctg aagcaacatc tttttcagcg cttccagact aaggatctgg 43320
gcacattgaa gtatgttcta ggtattgagg ttgctcagtc tagctcaagt attgttattt 43380
cacagcggaa gtatgcctta gacattcttg aggagactgg aatgatgggt tgcagaccta 43440
ttgactctcc tatggatccg aatgctaagc ttctgcctgg acatggggag cttcttagag 43500
actctacgac atataggagg ttggttggca aattgaatta cctcacagta actagacttg 43560
acatttcttt tccggtgagt gttgtaagtc agtttatgga ttttccctgt gatagtcact 43620
gggatacagt tattcgcatt cttcggtaga taaagtcagc tccaggcaaa ggattactat 43680
tcgaggatcg aggccacgag cagattgttg ggtacacaga tgctgattgg gcaggatcac 43740
cttttgatag acgttctacg tctggatatt gtgttctagt agaaggtaat ttggtctcgt 43800
ggaagagcaa gaaacataat gtagttgcta gatctagcgc cgaagccgaa tatcgggcca 43860
tggctatggc gacgtgtgag ttagtttggg tcaagcagtt gctcaaggag ttaaagttcg 43920
gagaaatcag caagatggaa ctagtgtgtg ataaccaagc tgctcttcat attgcgtcaa 43980
atccggtgtt ccatgagagg actaaacaca ttgagatcga ctgtcacttt gtcagagaag 44040
aaatactttc aggagatatt gttacaaagt ttgtaaagtc gaatgatcaa ctagcagata 44100
ttttcactaa gtatctttct ggttctcgta ttagttacat gtgtaacaag ctcggtacat 44160
atgatgtgta tgcaccggct tgagggggag tgttagttta cagatatgta tagtttagtc 44220
ttgtcccata ttggaagagg agtaatatct ccttgtagtg tataactata aatagggacc 44280
tcttgtattg tatttatcat ccaatatcaa taacatattt tctcccgtgc cttctcacac 44340
ttacatttat ttgatgaagg gcaaatactc catactataa taagtgtaaa cacaaactat 44400
tataaactct gtataagaaa cttcatgaat ccatcaatat tgaagatttc atcaactcgt 44460
aaataatgaa tacctttgga caagatggct cttcagccag ccttttcata gaatctggtc 44520
ttccaatgaa attgacatat ctagtaattg actcacggag gtcactagaa tcacagagta 44580
tacggctgtg gaagctttga tgtactgcaa caactgcgaa ggtgttgttg tttacagaaa 44640
ctgatctcag atcagtcaac tgcccaggct tcagatctgg gtacacagag tatagatagg 44700
atgtgatcaa ataatcgagg acagcatctc cgagaaactc cagtctctgc taaaggaatc 44760
aaatgttcaa agaaagaagt tgctgcaaag tactaaaaat cgcctacgca acaaccagaa 44820
agttacagaa aagtaggcta ttgaaaaaga gaaattccat acctgatagc aacctcctcc 44880
gtggttgtta tatgatggat ggatgaaggc ctgaatgagc aaacccttat ggacgaatgg 44940
ataacctaat aaattttcaa tggcaggaat atctatttca tcagcaagtg gcataaagac 45000
tttgcttgca gcgcaaatac tctttacttg tgattcttcg aaatctgtat agataccaat 45060
acatttaaga aatgcaattg ctgctttgaa gccactgtca actacaaaag cgccaacaag 45120
ggcttcaact atatcagcaa ttgttttctt acgcaaccac tgatgacatt tgctacacct 45180
aacttcagtc tttgcaccat cggttacact accacattga ccgtgtatgc ttttttctgt 45240
ttgtttgtta cagattacag ggcacggacg gcctactaca taaaagtggt tgggatcaaa 45300
tgattgatca cgaataaatg cctggcacaa agaaaaactt agagattcaa tcaaatcaat 45360
tgacttagag tataaacatc ttaaaaggag aaagctcata aatatatata tttatatata 45420
aacacgtaat caaaacatat ttacacacat acagtcacat taatgtatat tccatgacct 45480
cctccctcat aggaaatcac aattgcctct gatttctaaa aattcattag agatatgcgg 45540
tttcatctta tattcatatt tatgttcaat tattgagata cagaatgcta gctgtcttat 45600
ttatcacaca aaaagaaaaa tgcagaactg tctaactcga gaatccaaca acatagctca 45660
ttagaaattg aggaagtcat tttagtatgg tgagtatgtt cattttatgt ttatggcttg 45720
ctcttgacaa cattcggata tttgtgcagc ggacagcata ctcgtgacaa tcagagtaaa 45780
acatttcctc atactaggaa aagaaaatgt cagctactac tgaatattaa ggtgtatcaa 45840
gacaacatca aacaaacgta gtaggactaa tttttccaat gatgccacaa aaaaaacatt 45900
cattatcagc taatcaaata tcactatctt taacatgtta aatgtatgta tagaaaaaag 45960
tttactgttc cagacacaga ggatatcccc tcttttactt ggttggatag gagatcatca 46020
aatcttatag ctctcttaat cccaatttat acggtagtct ttctatttaa tatcttgaaa 46080
tgttttaacc cataccatgt ttatacaatt tttcacattt tcaatacctt gaattcattg 46140
tcattgtatc aaataatagg ttactcatga atgtatcaga tatttattac tcccttcgtc 46200
ccattctact ttatggttat cgactaggta taaagtttta ttagtaaatt taacttggtt 46260
attatattag tttagtggag ataatattaa agttatttga tacaatgaca aattattcga 46320
ggcctcatat taatcaacac agatgaattt ctttttttcc tgataagttt caacaagata 46380
tattctattt ctgctctttt atttgttttt ggggccatgt gagataaaag agagccacac 46440
gtgcatctga gtttgtgtta agcaatggca gtgtttgcac tttctcacaa tgaaataatg 46500
taaaatttgc aaaaattcaa aagccatgtt ttgaaacaag aaaaagcacg cattctctta 46560
tctgaacata aaagatgtgc tgtcatatca ctgaaaacct gtccatatct agcatttaga 46620
gttttcagca acaccatgta cctgtaaatt gtttctgact gctatcgtgt acagatagga 46680
attgttcaca atgtttgagc gccttctagt taactgtcct tcgtcaaagg catcgtatgt 46740
aagaaagaca tgcctcccaa ctgcaaactt gagaaatgca tcaccaagca cttcaagcct 46800
ttcaagagaa aaaggttcat tgcatttctc tgtagtaagt gcttcaagaa cctggtccag 46860
ttctaggcaa ttaatagtaa actaggtact gtatctggca tgattcatat gctatgaaca 46920
agtgaaagat gtaaaacaga tgtgtttgat tgagaaatac tactaagcta tgttgctcgg 46980
actctcccaa agtgtcgtcg gtgtgggtca aattctccaa agtagtgcat tttaagatcc 47040
gacacgggtg cggcagcatt ttggagagtc cgcgcaacat agctactgag gatggaagaa 47100
ttccttacat gatctattgt tacttccctt ccctcaggga aagaagcaga tagccagccc 47160
ttaagttcaa tagcgacaag taagctttca agacgatgca tgatcgatgg caacagtgat 47220
aatgagctcc caatatcttt ggaaaatcca attatcatga gctggcaaat ttcagcaggt 47280
agttcaacaa agtgctcctc tttatcacgc aactctgtgt agagggccag aggaaagtca 47340
ttcattgcaa aataatacac cacttaagtt actgtgtttc tcagaataat aggcataata 47400
aaaattgaac ttattttcag gagggaataa caagctgaca ttctgaaaat ctggcaagtt 47460
aaataaagaa gaaagcttat cattttctca tgtcatttct tggtgaagct agtcccaaat 47520
gacttactga agttttagaa gaaaatatag acccttcacc cttggagctg ctcggcacat 47580
tatgccagtg cagatatcct ctaaaaccaa atatcctttt ttttcaataa ataataacta 47640
ttaaaaccat gtatctcccc tccattatcc attctcctgt caaatcccgg ggtttttata 47700
agttttgagc caggaaacag gcctcagcat tattcaccca agaaaaattc tacgcaactg 47760
gacttttcac tgtaatatac taggtggcga ttttattatc ttctaccact attcctattg 47820
ctttcaccga aagaggttac aacacaattt gcctgatgaa aagctgatgt tgaagcaaag 47880
agaaaaaaac caatgttcag agactatgga agcagcaatg atactgttca aagaagtagt 47940
gtagcaaacc ctttaagcaa tctcttgcaa tttgcacttt agttagtttc atatttattt 48000
catataaatc tttcaactta tcttacttag ttgatttagc aaccatttga tgtcattttt 48060
tttaagtagt tccttcatcg aatttagaac tagggttctt tttttctttt tgatgaccgt 48120
ggtgtctgag ctacctttag cgaacctcga ctaattccac gaggtacctg ctacctccca 48180
ctagcatagg accgggtaac tctgtccaca tctccatttt gatttgaacc taaaaccttg 48240
tgattctcaa cccacgtcat tgaccactag gctgtccttt gggtgccatt tagaactagg 48300
ttttttggat gctctttctc acagataaat agaactagat agaactttat cagcactcaa 48360
tagtctaatg tcaatgattt tgcctctgac tttcaagttc tatagtagag tttgtggttt 48420
atttgcattc atagcagatg cccattagtt taatcaatat gcttcaacat gtatcggagt 48480
aaaacccttt ctttcaatcc cccctccctt gcatcacaag tcttaacgag ttttgcaata 48540
gaaaccgctc aactatgcag cttgaataat aagcaattac ctgaatagcc tttctttcgt 48600
agtaagttgt ccaaacagaa gagttgtttt gcttttatta gtggttgctc agggtacgaa 48660
agatggatac caaaactgta acagaaatct ctcacccatt agaatataca tgatataaag 48720
taatgtagct ctaaacaaga agagcacgcc agtcccttta gaggccagtt agggtaaccc 48780
agaaaacaag cagagttaca caattgcaat gaaaagaagt ctctctttcc caaactaaag 48840
caggttgtct gcttcctaaa caagtaaaga tacatcaata acgggaagtt tcccaaacaa 48900
gctagtatac gggagttatc ccacattaat taaattattt accttatcaa aaagggaaaa 48960
ggaagttaca tcaagaaatt ctgttagtac tcaaggctcg caaaaagtat aaaatagaca 49020
tatagtgact gaccataata aaaaaattcc agaagaaaaa aaagaacttc caaatacatg 49080
tgaggaaatt gtttaattgg ttctccagca gcaagcggtt aaatgctaat cgacctcatc 49140
aaaaactctt ttaactgcca ttctctttgc atctaatttg taaattttct ccccttttgg 49200
ccacaccaga ccaagggctc atttccactt tattaatact tgaactccta ttctggttta 49260
cagtagacag aaaaaaatat ctgcgcatgc gtatgctaga atcaacaaaa gaacagggaa 49320
ccaagctggt aagcaaagaa caaaaataaa gtcatttact tacgtatcat aatagtgttt 49380
gacatggttt tttgaatctt tatatatgct gtatgcattg ctttctttga caacatcaga 49440
tatgaagaaa aatgtatcct tgcatggaac atataccaaa ctattggcaa catcatgtac 49500
gcttttggaa ccattggcaa gttgcaactg ctcatcaaat ttggatatct cactattgcc 49560
tgcatatact gaagtcccaa aaattggtga tgacaagcat cttctgacaa gctcccagtc 49620
tatggaaatt ttattgtgtc cacataaatt gacgggaaga agtaggtaaa attttgaagc 49680
tgagtcaaca gaatcttgtt tttccaaaga tacaaattct gaaatgaact cagagcggtc 49740
aagaatgatc ttgaggaaca ttctctggaa tttctctgct agttgtacct gctaagagaa 49800
agtagtcaaa atattgaaga gagcctttct gtttatacta gaagagggtc aaatagttta 49860
cctcattgtt ctcaaaatta gtagctcctg atggaataag ctctgtctct acagatctac 49920
ctcgagccaa gttgagatca agtttcattc tctcagcctc ttggggaaga ggtgctttca 49980
gaaataggcc aaacttttta taaaccctat caattggaca aggtgaaaag ttaatgtagt 50040
acgagttaag gcaaacagga ctctctgtct cagtccatgg ttctttaaag gcagcgggaa 50100
caatcatctc atggagctct tctcgtgcat cttcgcctat gacatcaaca ttacaatgat 50160
gacaacaagc accaaaataa cacaaagcat attgaaaatg cttttattag aataattttg 50220
cctaaccatc tgagctttct gagtcagaaa aaccatgaat caggtcttca tcttcatctg 50280
cttgatccgg caaaagatag tcagtgagtg ctccaagttc atgcaagctc ttgcaggctc 50340
ttaaacaggc atctttctta gctgcttcta tagaagattg aggagcactc acgatttgat 50400
gcattggagc atttgaaggt aaaactaatt tgcaaatagt tccatctatg tcatcaaagt 50460
agaagaactg cggcttgggg cagaaaaacc tacaaaagaa gcaaaacgaa cagaaagaaa 50520
tcgtgttaac ccatgaagat atgagttccg aaagcaaaat ccacccataa gtgatacaga 50580
acagaataaa ctttaattag aaaaagagaa acagaaataa caagtgaaat tcagtaaaag 50640
atcatactcg tcacgtggaa gcttggaaca ataatggtga agcaacgaaa tgcttgatgc 50700
agaactgatg gttgcaccag tcatatctac tttgtatata ttttcctgaa aatctataac 50760
tgtcgtgcaa gatttcctgg aagaaatctc atcattcatc cgagcttcat ttcttgaaaa 50820
atgctcgatc aaattaagct ccctttggtt atcactgcca agaggtttgt gtcagagata 50880
ttgctctgat gaacttgaca ggtaataagg tacagaaagc ataaactttg gagataccta 50940
tcaaccaaaa atgcatattc agactttggc atgcgggcac gccctctaga ctgtataaaa 51000
ctggcaacag tttcaggaag atcaaatcgt ataacgaggc agcatgtctg gatatcaagt 51060
ccttcctcgc caactttggt ggcaaccaat aagttgagct gttaaattga gcaatggata 51120
tgcgatcaat ctcacccaaa ctatcagatg gagactcaaa cataaacatg gagttaccct 51180
cccagaggtc ctctggctaa gagaatcaag cgagcagaga aagaatctaa caaagaacca 51240
atacctcacc agaacggaac ttattgagaa tgatatctgt attttttcgt gacatactct 51300
tcaatcccga gtgcactcct acaagaaacc cacacttcca agaagataaa actttcagat 51360
gctgaagcat atatgaaaga gatctcgcag tcacgatcct attgacaaaa attatgcact 51420
tcatatctgg ttgtaccctg aaaataaaga gagggagata ccaaaatgca gaatatgaag 51480
ttgagtctcg aattccttag cgactgaact cactaagaag aagaaatata catccatgat 51540
atcaaacaaa acgaagcatt tattatacgt attgggtaaa ggtatggtat gaaagcaaga 51600
aacatacatc aatgacttca aacaatattc ttattattta tatcgggtaa aggtacatta 51660
tgaaggcgaa agatcacgct gaagaataaa cttttagggg aagaaatgtg gttatcaact 51720
aagttcactg ccaatactcc ttcggttgat tttattataa tcggatacaa tgacccataa 51780
gaacacccct caaagtggaa ttgcctattt tgtttccagc tacttataaa tcctgaataa 51840
gttgcagaga acaggaacag gaaattattc atttagctac ataatgacta acccgaagtt 51900
ggaaaggatt ccaattagac gtaaaagctt tttggagaaa taaggctcct tcagaacttc 51960
cacaattgcc aaatcaggat tcataccatc tgcatgataa agcatatgtt agacttgtaa 52020
tgtacagagg aaaacaacaa gaatatactc gagccgcaac acaagacatt cttaaaatca 52080
aaggtttttt gatatttctg ttggaacaga tcattctttt aagcctacat ttgcaggagt 52140
tgacttttat catatgccct tagtcttcat taaaagaccc taaagcacag caaataaaat 52200
tcgaaatcaa gtctaacttt acacagaggt aaaaaagagg tgtggaaaga tttctgttag 52260
tctgaaactt gattcatcat acttgttcag tcacaacatg attcccatct agttgtcaag 52320
ccttttttct ttgaaatgct aacatcgcac tgaaaactaa ggcagcttat attcttgctt 52380
cattggtaaa ttgaacatca aatgataact ttcttccatg cataaaactt cttgctttag 52440
tttctccatt cttttattta ttgcaatagc gattgtgaaa agttacaaat tatgtggggg 52500
aataaactct attaaggaga cttttcctat ttttgataaa tatcgcatct tcctatcctc 52560
tccagtctct tagcattttt ttcacctctt ataatggaat taattccaaa tttgtaatat 52620
ggatgtgtag cccaattgtg tttgaacccc caagtgttct acataagaaa tggatgtctc 52680
cgtttggatc aacaagatta aagtgccata tgcaaacaat agatgtgcga catattccat 52740
gtcatgctct cctccaacaa cccgaaatta cactaagaat tcactagcta cagattataa 52800
cactagctct ctattataaa caataataac aacggcaaca taggtcttcc tgccgaataa 52860
ctttttgctc acaataaccc ccaccccagc ccccccacac acatatacac acgcaatggg 52920
tatgcactag ttctccactt tctacaactt tccccaagaa accattctgg ataacgacta 52980
atctaaaata aaataaaaaa tcaattggca aggtcacatg ccttctcatg tctagtttaa 53040
ctagaattcc caactttcca cagatcaata cagaattcgt cagttcgttt gagatcacag 53100
gagcatccat acccttcaac cagtgaaagc atcttttttt ttgaaatgat aacaggtttc 53160
attgatatat agataaatct cagcgccaag atagtgctga gcgaaacggt ccctagttac 53220
aagacttcca aaaactaaga gattgatgaa caaaaacaag tggtgaaaaa ctagtcttgt 53280
ggcatttaca aggacccgat gagatcaact agggaatctg catcttgtac taaagcttct 53340
ttacaccaaa agtgaaataa aaatatacaa ttcattttaa tcttctgttc agggtttgct 53400
gagtcttcaa aacatctgga gttcctttcc agccagatag tccaccaaat gcatgctgga 53460
atgagactcc accacctctc ctggctgctt cctgtagcta aaaagtccca actagacagc 53520
aagtccatag tcactctagg catcacccag cttaagcttt tcatacttat gaaaagctgc 53580
cacaatctat tggacacctc acaatgaaga aatagatgat tgtaggtttc gatggccctt 53640
ccgcacagaa aacatctgga gcacagaggc attcctctct tcattaagct ctcgtgtgtc 53700
agaacagcct gtttgaccac tagccagcaa aacacattaa cttttaaagg gaccttcaac 53760
ctccatatgt gcttccatat ccaagcctct tgttgctgcg aacttctgtt taaaacctca 53820
tatacagatt tcacagtgaa aactcctttg ctattgtttt tccataacag tttgtccact 53880
tgctcagttg gacctttgaa gttttccaaa agtttcagaa gctcaattac tctgatcacc 53940
tcccaatcat tcagaaatct tctgaatctt aaattccagc cttgctgatt ccaggtatca 54000
gcaatagaag catctggctg ttgcgctaaa gagtatagat cagggaaact gtcttttagt 54060
ggagtattcc ctatccaaac atccatccag aaagagagtt tttgcaccat tgcccacctt 54120
tatgcatgaa ttgctaatta ggttttgcca gagagatcta atagatctcc acacactctg 54180
gatacaatgc tattcaccac aaatctcaat ctcattaaca acacatttac cattgttcag 54240
tttccagcca aattgatagg tccgaagtcc ttatttatta tctgttgctt tcctcttcgg 54300
aattagaata aagaacaaag aatttaaata tctcttaagg gaccaaaccg atgaaaatga 54360
cgcacgcact ataaacattg tagtttacca ctttccatta gtgtttaaaa gaggcaagag 54420
tgaaaccttc aaatccagtg ccttgtctcc taaacaactc ttcatcccct actccactct 54480
ttcagcttca aatggtttct ctagctcctc tattttcctg ctgtcgaatt tctagaaaat 54540
aataccacca aatcctgaca tgtgtgccct ttctttaatg aaatttatta cttcatcaaa 54600
aaaactacca tcaaatcctg acccctactc atcatatttc tcataacgac agatatacct 54660
gcaaaatcta ctctttattt tcattttcct tggagtacct agtcatctat ttgcatcttc 54720
tcaatgagat tacatcttcc atgtccacta tgtgcattgg caggtgaaaa gaatttggtc 54780
ttgttatcac cattattcag ctgaaggaaa tttggtagta gtgtcaccca agcctatctt 54840
taacttcctc cctcaaaatc tcaacatcat taaaagcaaa ctataagaca gttaagtgta 54900
aaatttgcta tgcaaatata gttataatca atgtaatata gcattagtga ccacaagtgg 54960
gtaaatatag ctatatgtgt tgatagtaaa tgatgaccat aaaaggattc aggcataaga 55020
tatttgattt catgtgttcc ctccattctc ttatttctcg cataaaccat caccttcgac 55080
caactgcaat gtatgtactc ctgtaataac tctgtaatgt ttgtttccac tctgccagat 55140
atctccatgt ttcatttctt gaggtttctt ctacttatga gcttcttggc tacctaaaat 55200
gtggtttcct ctcgtgtact taactatccc actgtcttaa ccatctcttt aaatccttca 55260
tgctgaagcc atatgttctc agatttgatg gagatggtcc ttttataacc accagttctt 55320
taagtgaata ggacaatgat ccaacactaa tccgtacgcc aaatgggtag agtgacaaaa 55380
agaattccct cccattcagt cgataccaag atcaatcctg gaaatcgtcc ttctattcct 55440
ccaagtgaat cttgtcccaa gtgatggcaa gtcgatgacc acagttgaag ataaagccag 55500
agaattcctc tggaacttta ccaccaatgg tgtaaacact attccttcct tggcaaaatc 55560
agcggcaatc acctatgtgt atttgccgtt tcatctaacc tcaataattc ctcctacagt 55620
gtccccattc catttataca gtccccatac agcgttaaga agatccgcgt aaatctggat 55680
ttaaatttca tttacttgtt ttaggtgtac tagttctcct ccctgtatgc ttatttgtca 55740
ttggtgaaat gtgttgtgcc gtctaagaac acgaaggaat aagaaaccaa gtttagcttt 55800
ggcaaaggac agtgtttaaa aaagcgctcg cttcatcgct ttaagcgaga agcgaggcga 55860
agcgtgaaag gcagcgcttc agcttgctga agcgactcag gtaggtaaaa gcgaccgctt 55920
ctctgtaaaa agcgagaagc ggggaaagcg aagcgaagag aagaagcgtc cgcttctcta 55980
tattaaaata cccaacccta ttttattaaa aacaagtttt tttggattaa acactgatct 56040
tcaacaacaa cgactagtat tcttcaactt ccaacagcaa cgacttcttc ttcatcactt 56100
ctgatttctg aaagaatctc aaatcatcaa ctagggttgt tcttcttctt cttcaacttc 56160
aagttcaaga ctttaagact tcaacaggta tgttctgaac ttctgatttc cattcttctt 56220
cttcttcttc ttcttattct ttttctttct aaacgtccaa aaagcagcga aatgctggcg 56280
aattttttcc agaattttac tgcccaattt ttccagaatt ttattgcccc cagaatttta 56340
ctgcccaatt tttccagtta ttaacaaaga attcctatga ttttttatat cctttatagt 56400
ttattcttag ttcttattgc ctttcttatg tgttatgtag ttgttctttt aatggcgcca 56460
aaagaagata ggaaagatcc ggcttgggct tactctgaaa gagtttgcga gaccaacaag 56520
atggcaatta gatgtctttt ttgtgacaag atttcaaatg gaggaatcta tcgtcaaaaa 56580
gcgcatctaa tcggcggtga tccaaatgtc gcatcttgtc ctaaagttcc gtcgcatgtg 56640
aaggaagatt tgaaagcatt ccttcataaa aagagagagt taaagactca actgattcat 56700
gaacaagaac tgtataatct tgatgacgat gatgaaacag aagaaggtga cgatgcttcg 56760
tcgcttccac caaaatcaca aaagcgggga aggatgcaac caatgtcttc tagttgtgga 56820
tctactggca agaccaaagg tcctatggat tgttacttct cgcaaaaatc tggagataag 56880
gaaggaaaaa gtggtaatcc tcaaattgat gccaaaacga ttttgaggga tcgtgcaatt 56940
acaatgtttg cgcggtggat gtatgatgca ggtcttcctt ttaattgtgt taattatact 57000
gacacttttt ctgcttttat tgaggccgta ggccaatatg gtccaggaat gaagcctcca 57060
acatatcatg aagttagagg gccatatcta aaaaaagagg tggcagaggt gaacaaaatc 57120
gtggaggagc acaaagtaga atggaacaag tttggttgtt ccattatgat ggataagtgg 57180
acggcgagaa atggaaaaat gatcatcaat atcttggtga attctcctaa gggaagcctg 57240
tttcttgagt ccgttgatgc aagcgactct tcgactgatt caaccaaaat gtactccttg 57300
ttcaagagta caatagactc tattggagca gaaaatgttg ttcaagttgt cacggacaac 57360
gccagtgaaa atgttaaagc tggcgatttg atgtctgctg ggtacccgca tatttattgg 57420
actccgtgtg cagcacattc cattaatttg atcttcggtg acattttcaa ggaaagaccc 57480
tttagttcaa tctttaatca ggcaattaga gtgcattcct atattgttca aaggcctttg 57540
ttattgaata tgatgaagag attcactaaa caaagaagct tggtgaaacc cgcaaagaca 57600
agatttgcta ctgctttctt gactttgcat aggatgtatg agcaaaaaag caatttgaag 57660
aagttgtttg tttcagatga gtacactaac agtgcctatg gaagggaagc tcgagggaga 57720
gaatctgcag atattatact ttctccttca ttctggaaca atgtggttca tgcattgaag 57780
attggtggtc ctttagttaa agtgcttcgt ttggtggatg gggagcaaag gccaccaatg 57840
ggctacctgt acgaagcaat ggatagggca aaggaggcta ttcaagtctc gtttagtgat 57900
caaagaaaat acaaaagagt ctttgagatc atagataaaa ggtgggatag taagcttcat 57960
agccctttgc atgcagctgg acttgttttg aacccggaac tgttttatga caatgaagaa 58020
aggattctag gagatgaacc tttgtggaat ggatactatg aatgtattga gaagttgata 58080
cctgaagaat ccgtgcaaga taaaataaca gagcaattta gtatttatag gaatgctgag 58140
caactttttg gaaaaaacat ggcgattaga caaagaaaga cgaagtcacc aggtgagcga 58200
gtgcttatat gttgttttat agttaataag ttatttcttt atcaatatta tgttttgaaa 58260
atttgttcta cttctacagt tgaatggtgg aagcaatatg gccattccac tccggattta 58320
caaaagtttt ccatcaaggt tctaagtcta acatgtagct catccgggtg tgaaaggaat 58380
tggagcgtgt ttgaacatgt aagaactaag aagaaagatt tagtatattg agataattaa 58440
attatatctc aattgtccta aacttactaa ttacttatta tttgcagatt cataccaaaa 58500
aaaggaacaa actaaccttg aagcgtctca atgatctagt attcattaag tacaatagaa 58560
cattgaggcg tcgttacaac gctcgcaatg taattgatcc aattagtttg gacaacatcg 58620
atgatgctaa tgaatggcta actggagtcc cggaagatca tgcagatgaa gaagtatttg 58680
aggaaacttc tgatttcact tggggtgatg ttgcggaggc gcgtggaatt ggggagagga 58740
tttatggttt gagggggagt acctcaactt caagttcaca gaggaaggga aaagaggcag 58800
ctactttgtc cctagttgat gaagaagaag aagttgaaga agatgacgag caatataata 58860
atgatagtgg aatacaagaa tttgacaatc ttgtagaaga ataggatgct cattttgtgc 58920
tttaattgat gctactattt agtttttaca ttgaagtatt gaacatttgc ttacaattac 58980
atgtgttgtc tatgcaatat atatatatat atatatatat tttaaatttt gcttcacttc 59040
aaaaaagcga gcgcttcgct tctcgcttct cgctttaagc gaaatgaggt ttgtcgcttt 59100
ttctcgcttc acgctcttca caacactggc aaaggaacac cctgcttaat cagcggaatg 59160
ctataaattg attcaaactt ccaaagctaa acttggcttc ttgaaccaag taatccatga 59220
tcaggccagt aagaatagaa ttcttgttca agctagaact cataagaata cttgtaatga 59280
tggaaagaat acaaatagct atagaacagg aatttacaat agaataaaac ataccattag 59340
cacaaccaga agtaaacact gcagcgacct gactcagata tctgtcacac aaagagtcat 59400
cactagcatt aacatcagct tccaccattt gatggcgctc atagtgatcc ccctttaaga 59460
ggatgcaact agccttcacc aaaacaaggg tgcaacttag aattgaattt tccaactgta 59520
agtcttaaaa ctaataaata gaaaatagat cgtgatgtct tccctgtaaa ttaatagtgc 59580
ttaaatcatg ctaagcataa ctagggaacc aacaagattc tggagtgcat actctactga 59640
aaataatgtc taaactaggg taatgcatgt gaactctcca gctgaagtgc tttaacaata 59700
cacacaaaat aaaatctgaa gtgcctaaag atgtccggag atactacttc agcagcagta 59760
agaaagtaaa aacaaaaaga gaatggaagg tctacaccta actgatatgc agtcaaaaag 59820
aagaagctta gagagttgta cagtgagctt gcggagttgt aactagccgt taggattagt 59880
taaaagacgg gagtttatag ttttgagggt gtgacacttt agtccctctt atagtttatt 59940
taatactttt gtgtgtttac aattggaccc atgtaattag cctttagcat tacttttggt 60000
cctatagagt tggttagcta gttttgtctt ttagtgagag tggagtatat attcctgtac 60060
cttttggtca tcaatcaaag aattattttt ttgataagag ggaaacccgc agccgctaca 60120
cttggtgcgc gctgggtaaa cctccccttg tgtaatagtc tgcaaaccac acaagggagg 60180
taaaccgcac taggcaagcc atgtgcaaca ggctcaaccc agaaggcatt gagggggatt 60240
cgatcccagg tcatccgtat ggatgactgc cctccaaacc aacagggcaa ttacacaggt 60300
catccgtatc aaagaattat tctcttaccc taattttatt cctttttagc ttagttttct 60360
attccttctt ttactgttcc attgacggct gcaacagtgg tatcagagca cgacctcggc 60420
tctgtggatt aatggcggaa ttgaatgaag taatgaaaat gttacaccaa atttctacag 60480
agatgacagg gtttacagtt aggcaagatc agcttgaagc tggccatgaa caatcttgca 60540
gaaatcagga ggaagccttg aatgaaatca gagaagtgtt gaacgaggtc atccatggcg 60600
gaaagagacc tgagagagac aaggacctca accatagtgg agaggagctg tattcgccaa 60660
gtgataaacc actcgaccta ggtaaggtag ctactccttc tgttggtgtt aacagctcaa 60720
ttcctctagg aacaagtaat aacactgttc cattgactgt gagcaaccaa attcccaact 60780
ctcagttacc tccacctgtt attcctgtta atttcaaccc tctcccactt cctgtgaaca 60840
ccatctctca accccaagct cctatgacac taggccgagc tgccataact cagttcaacc 60900
agctccaaac tcaaccaacg cagcaaagct tctctcccca acctagattt accactgtcc 60960
aaccccaacc atttcttact cctcaaggtg ccaatagacc ctactactct gcccagaaca 61020
tgccaatgtc atatggccct tacccaccaa catattaccc acaacctaca cacatttcac 61080
catccctgta ccaccaaaca ccctatatcc agacacctct tcagcctacc cctgcacata 61140
taccctacca aaacaatccc atgtatacaa accagccaaa cacacaaaat gtagcctatc 61200
ctaacctgcc ttttactaag aacaccaagg ttgaattccc taagtttgat ggtgaagatt 61260
tgagaacttg gttgtataag gtggagcaat tctttgctga agaggaagtc accatccaac 61320
agaaaatgaa gctagtatct cttcactttg aaggtgatgc ccttcagtgg cacttgggat 61380
atatgaggag caggggacaa tcacctcttc ctacttggga ggagtatatc tgggccttgt 61440
gtgatacttt tgggactgaa tacactgatc caatgactga gatcatgaac atcaaacaca 61500
cagggacagt gaaggattac caaagagctt ttatcaatgt tatgactagg ctcaacatat 61560
ctgtagaaca tgctatcagc atattcttaa acaacctcaa gccagaactt agccatgctg 61620
tgagaattgg gaatcattgt acattgcccc aggctttcta cttagctagg ctacatgaat 61680
ccagctttgc agctcagagt aaggctatga aaatgggcaa ctctgtgtca tctgtgaata 61740
gagggaacat gagtcatggt cagaacaatt ggcccaggag caacttgaat gcactcaaga 61800
aaccaatcac agctaaattt gataacaata gaaaaaggag gttgagtcca acagaaatgg 61860
atgagaagag ggctcaagga ttgtgtttct tttgtgatga gaagtttgtg cctggtcaca 61920
aatgccaggc taagaggcaa ttgttttccc tagaactgga agcaggtgag gtaccaatag 61980
aggaggagga agagatccaa atagaagaag aaggagaaga gatagctaag gaactccctg 62040
agaactgtgc tatttcccta caggctttaa atggaacctt aggttatcaa accttgaggt 62100
tgagagggtt cacagagcaa agacccctgg aaatcttcat tgattgtggc tctacacaca 62160
acttcataga tgaaggaaca acaaaaaggt tggggtgcca aataagcaag actaaacctc 62220
agctggtaca agttgctgat ggtagggaag tgcccacaga tagtatatgt aaggggtttc 62280
aatggttaat gcaaggggct gtgttccagg atgactttct ggtatttcca attggcaaaa 62340
gtgatatagt attgggaata caatggctct accccttaga ggatattaag ttcaatttta 62400
ggaagctcat gattgaattt gagtatgaag ggctgctgct cactttgcaa gggattcagc 62460
ctaaattcaa aacagtccaa gcaaaagcaa tgaacaaaat ggccatcgaa ggatcccagt 62520
tcttcatggt caaggtaaga gaggcagaat gcaaggaagt ggaggtgaca gaacttgaaa 62580
aagcttagga atctagggaa ctcaagcagg ttcttgatga gtaagcaggg atatttggag 62640
aacctacaca gttacccccc tcaagagggg cgtttgatca ccatattccc ttgatggagg 62700
gcaatttacc agttaactca agacctttat aggtactcag cagtcaacaa acggtctcaa 62760
tatttgacaa ttagaccctt cattgttaaa acagaccaaa gggccctaaa attcctttta 62820
gaacagaagc ttcacactgg aacccagccc aaatggatca ctaagttgat gcaatatgac 62880
tttgaaattg aatataagaa aggaaaggaa aacaaggcag cagatgcctt atctaggatt 62940
ccactgatcc aacttgctgc tatgacctta tctactgtga ggactgatct gctagaaatg 63000
attatgcaaa gctgggagct agatgaagaa ctgaaggcag tcgttcaatc aatacaacag 63060
ggagaagctg atgcaaaggg atacactttt atacatggcc aactcagaaa gaaaggaaag 63120
atagtagttg gacctaatct tcaacttagg aaggatatct tgcaattgtg gcttagttca 63180
acagtaggag ggcgctcagg gatagagaac acctacagga aggtagctgc tcttttctat 63240
tggaagaaca tgaagcagga agttcaagaa ctggtcaagg catgtgatgt ttgcaggggc 63300
acaagtacga caatgctcct tatcctgggt tgctgcaacc actcaaaata ccagtagcag 63360
catggagtag tattagcatg gatttcatag atggcttgcc taaatctaaa gaaaaacagt 63420
gatttgggtg gtggtggatc gactaaccaa atatgctcat ttcatagccc tttcccatcc 63480
ttattctgcc aatgatgttg caaaactttt tatggaaaac atatacaagt tacatggagt 63540
acctgaggat atcattagtg acagggatcc aatctttacc agtaaagttt ggcaagaatt 63600
gttctctatg atgggagtaa cactcaatac ctctactgcc tatcaccctc aaacagatgg 63660
acagacagag gtagtgaaca ggtgcctaga gacctaccta aggtgcttct gctcagactc 63720
acaatcatgg tcccaattct tagcctctgc agagtggtgg gacaatacaa ccttccacac 63780
ttctatacag agcacaccat atgaagctct gtatggacaa ccaccccgct acatttaccc 63840
tacatggctg gagattctca agtagaggaa gtggacagaa gcctattgac tagagaattc 63900
aagacacaat tgctgaagta tcacctcaaa agagcccaac agagtatgga agaacaagcc 63960
aacaaacata gatccgacag acaattcaag gagggagatt gggtttacct caaaatccaa 64020
ccatacaggc aactatccat gtcaggcagg cactttacta agttatcagc aaggtactat 64080
ggcccttacc aggtgttaca gaagatagga ccagtggcat acaagttgtc ccttcctgcc 64140
cagctcttgt tgcacccaac ctttcatgtt tcccagctta agatctgtca tgagttaccc 64200
cctactataa cacaccctcc tgtcatcgag ttgtctagcc cttattgccc acaaccagag 64260
aaaataatgg atagaagact gattcaaaag ggaaacaagg cagtggcaca tgtgttggtt 64320
aaatggaagg agttaccatc agaattggca acatgggagg actattcagc tctaaagata 64380
cgctttccat ctttccttcc ttgaggacaa ggaagatttc aacaggggag aactgatatg 64440
cagtcaaaaa gaagaagctt agagagttgt acagtgagct tgcggagttg taactagccg 64500
ttaggattag ttaaaagact ggagtttata gttttgaggg tgtgacactt tagtccttct 64560
tatagtttat ttaatacttt tgtgtgttta caattggacc catgtaatta gcctttagca 64620
ttacttttgg tcctaaagag ttggttagct agttttgtct tttagtgaga gtggagtata 64680
tattcctgta cctctgcaga tttggtcatc aatcaaagaa ttattctctt accctaattt 64740
tattcctttt tagcttagtt ttctattcct tcttttactg ttccattgat ggctgcaact 64800
ctgccaaaaa ctctatgcca ggtcaagaga gtcgattaaa ctgcacaagc ttttcaaacc 64860
agtctgcact agcttttcaa accagtctgc actctcttgt tttagaagag agctaggagt 64920
ctggtcaggt cttgatccta aatcatgggt tccatatggt acgcaagttt ctccttttta 64980
atgaaattct aaatgatact caagtaaaaa gaccatttat aaagtttgct tgttggaggt 65040
gacggcaagg cggggcaggt cttcccctgc taattttttt ctaatataat tgggaacaca 65100
acaacaacaa caacaaaccc agtttgatct cataaatggg atctggggag ggtagtgtgt 65160
acgcatacct tacccctacc tcatagagat agagaggttg tttccgatag acccttggct 65220
caaggaacag acctacatca atctattaat ataaaaaaaa cttatagaaa gaataaattc 65280
taccccctaa acaaaactcc ctaaaagact atattgtgga cgctatgttg ttgtccttgt 65340
tacgagaaga aaacgtcaat ttatagaagt acaaaatttc tcctccaaga aaacgataag 65400
gcatatgaaa gagatttaac ccttttagga gtctttttcc tttccttcaa gaaagagagt 65460
cctaatagaa tagaaattca gggcaaaatc ctaacaatta gatctcctgg tagtgcttca 65520
gataacttta cttcactaat ctttcaattt cggttttgcc atttccccct atctctactt 65580
cttatgaagc ttcagcccat agaattcgta atgtttgaga caatggaatg tgcgtactat 65640
aagataggtt gttaatccaa tggagagaag tgataaagag ataaatagaa gaaagctcaa 65700
aaatgcagca ggaaaatacc ttgcatccgc aagagaactg aacatatatt ggagtaaaat 65760
tttcgcatcc cccatttaac acgaataaaa tattaaatgt gagcaataaa atatctgata 65820
acctaagagt catgaaagat cagggcttgt gaaaacggat taggggacaa acaagaagaa 65880
gtgcaacaaa acctgtaatg ccccaaagac acctaggttt tccagagaaa aaattagatg 65940
tccatgcagt ctcttgagca tcttttttgt gttcctgaga gtgctatgat cagctgcttt 66000
cttgtgaagc accatcacac actgtcaaat catgagaaca ccagggagta tttagtcgaa 66060
gactaattag aaaatagcca tctcaattac tgaccagata atacctggct tttaatctct 66120
tcaagcttct gaaagtaagc tttagttagg cacgcggtgc caggaccata gtagtataca 66180
ttcaccttag gtgatgcaac aaactgttcc agttcatcct tgtcttcaac agaatacacc 66240
tgtgatcata catagacaga aattaaatat agaaatatta atgttcctat ttccttctac 66300
gcttctacaa cagtatgggt atgaaccaag gttagcagtc cagctcagcc cagacaggta 66360
aaatgccgcc aagctagtca tttgttacct aacaatgaaa cacccacagc aagagaccca 66420
ggatacaaaa tgatatctag gaaattggag tcgcaatctt atgacagttc ttaacaactc 66480
caagaactaa taaaccaaat gacagaaacc catccttcac aagtaactgt ttttggactt 66540
tattgttccc ataataatga tgtgaggaaa ctgtaatctt ttatagtcat cctttttttt 66600
ttttcttttt ttctttagaa aaataattta ttgatgatgg aaaaaaaggc ttatgtgtac 66660
aatagtagca ccttagagcg aagtaaggtc tcaaggcctt caacagtagc acctgcaata 66720
gtaagaagac aacataatat ctgagagttg aggagcatcc aaaaacaaat gtagcttaaa 66780
ggaaagatac atcagtttcg cctggcagaa tgattagtat tgaaagcaaa gataagatag 66840
caagaactat caatctgtca cagcaattga ccaatgcatg tcatggcaag cagatttctt 66900
tccaaaaagg cacagacccc agagatcaga tgagtttttt aatacaacta caatagaccc 66960
agtgtaatcc cacaagtggg tctggggacg gtagtatgta cgcagacctt acccttacct 67020
tcaagaaggc agagaggttg ttcagattag ttttttttat aagtccaaaa atcagataac 67080
ttgaaggcat tttcagattt attttctgat aatactcctg taacttctgt tggtccaatt 67140
tctaaataga attcatacag gtcatgactt tctctagaag aatcaactac gtaacgaaga 67200
tacatatatt gtcatgcata aggaggtaaa attccacata tgcagatgag agacacttaa 67260
agaaaaagga ggtaaaaagg gtgcgcaggg acattttccc agtcatacaa ggctatatta 67320
gacagccaat gatgtttgat cattaacata gacaaagaaa tatcataaca acaattcctc 67380
tgcttctcca gtcagttttc aatcagtttg accaatttta catggatagg agacggggat 67440
aaattcatca tttcgaagta ataattaaag atttacagat ctcacaagat ggaaaaactt 67500
tttcgtttgt aacaagtaag aagttgtcca gagaattgac ccctggaaac ccaagaaaga 67560
gacacaaatt atcaagtaac ctcaagtgtc agttccatgt caatcccatg tgacattata 67620
tcattctgcc gaaaattact gtgttgaatc tcataacagt tacattccat gacaatccct 67680
aagcatctta caagcactgt gaagtactat ttgtcaattt tccctagatt aataactata 67740
tttacattat aaaaaacgtg aagggttgtg aggctggacc aggtacgaag aatgaatcta 67800
tatctgtgca cggaaattgc tggcactagc tagcgccttc cttatactaa tataaaacgt 67860
tgggcctctt ccccttattt attaatatta ggcaagttgc tcgaaaattg tcaagtttaa 67920
aacacgaagg taacatatga aattactgat gagctatctg attggatcca gctagttgga 67980
gaaagttaca acatattgtc accgggtgaa tccatcccaa aaaagcaaca atacgcatga 68040
agagtacagc acaatatatt accttttcct gatattggag atgcagtcat gccaaatata 68100
cggggcagtt ttactacatc aggtttgtaa aatatctgtt aaaaataata tacatgaata 68160
agaaggctac tacatacaaa acaaagcatg tttcccagcg tataacacca gctcagctaa 68220
ttaccttcat aatctcagca taaggatgat cactctcaac ttgtgcatag tggcactcat 68280
caaagatcag aagagcaata aattcaatcc tgatatagca gtgggaaaga ttatgtaata 68340
gtatttgagg ggtcataaca aggacctgaa caaacaaagt gcaaatttgt tggtcaaaac 68400
attcacatag tgtcaacaaa aaaataattt acagtataac agtcagtcat caccaatatc 68460
cacactcatg cacagtccaa aaaagggcct aagatgagaa gaccacagta tataacacat 68520
aacatggttc agtcaatcta ctacatatag ttaacagaaa ccatgttgat tccttttttt 68580
attcttagtg actataaagg ataatttaaa ttaataaaac aaaacaagca agtgttgacg 68640
tcaacattta cgaaagagag aacaaaaaat tgtaggtccc taccaaaaag tgaaaggatc 68700
caacaaactc catcaaacca tctatgtcat gtatagatgt acaatgacac taagctaagt 68760
gctgtaaaca aaaaaaaatc caaaatgtgt agactttcta tttctttcaa agtatccgtg 68820
acaccctcga aataacccat gtaacacagg aattccaacc cgtacttgtg gctcttctca 68880
gaatctccct ttctcaagca cataagcatc atccactatc ttcaaaaagg ctcagaaaat 68940
tatgtaagat ttcaattgta attggacaag ataagaatac attaatttag ttgaaatcag 69000
taattcaggt tatttttatc cctaacatca gttattcaag tttcaaagaa tatttgcatt 69060
aaaatctgta attggaagtt tgcataccaa gaatgcccaa ggttctgtct cagacaaata 69120
acattcagga gacgatgccc atcactaaca aaaaaaggtc atgcagactt acctcatact 69180
gttccatttc tttttcccag tcttcgtggc tcttcaaatg cttggatttc ccgcagtatg 69240
tcccaacttt gaagtcgaca gagtcttcta tgaccttggc ttgctattcc aatttcaaaa 69300
gcacatgaaa aagaaaataa cttttatgcc catgctttat caagtttcag acacactttt 69360
taattcccca cgctgcccca agttgtaaga gtacactcag aaaacggaat gggtttaata 69420
ggagtaataa gattctaacg aagagaaaat tagttaaaca taacaaatga cattctgaat 69480
tgaagagcgc tttcttgttc tctacgagat gtaagactat aggccttttc atgctaatca 69540
tagaccaatt ttcagcaaaa tcgaaaaact ctatatactt aattattttg tctagactga 69600
aacaattagt cttcgattat ttaataaaat tcctttcgtc atatatgcga agaatattgc 69660
ttacatacta gccacaaaat caataaaaat ttcgatggac aaatacgaca agtaaagaga 69720
taagttgaaa actcattaat atgatgaata caaagctgga acagccactg gacaaaagga 69780
gcgatgccat cagaacagta gccgcaaaga tatgtggtgc ctttgaagca gcagaaagcg 69840
caacggcatc aaagtggtca cccaaaagaa gggctttgat tgggccggtg acataagaga 69900
ataaaattgt cacttctatt ttagtgtccc catgaatcaa caaaattatt gctttatcaa 69960
aaaagagact caattgaaag gagaaaagac aaaaagggaa ttgtgtaaaa tagctggcgg 70020
aaacatgctt aaagctctca tataccacct caatagcaag gaagatattt gatatttcag 70080
ccatctgatt tcatgtaaat tagttttcat ctttgatatc ataaaattta aaagtttgag 70140
caaaagccaa aaaaaaaata aaaaataagg aaacctgttg caccaacgcc acagtgggag 70200
caagaaacac gcaaatgctc ttctggggtt tccttatcag ctgtcccatc tcatagataa 70260
gcaagacggc aatatgagtt ttcccacagc ccgttcccag atatacaaca acattctcct 70320
ctaatgcttt tttacaaaga tccatctgat acctgataag aaataaaatc agcaaagtct 70380
tgctataaaa tcatcaaagc acctatctca ttgtttttgc cattacttaa acatcattat 70440
tcagtaaaat agagtagtta aattctgcaa gcgtttgata attataaaga acttcagctg 70500
tttgaaagtt caaaggtttt attgtaacaa caccttagca aaaaaaagtt ctttttttta 70560
taagaaaatg tagagatttt attaatgagt aacaagaaga gagagtacag aaggaatgag 70620
cttttcctcc taaatattga aggaatatat cagatcgtga gaaataatac actggaaaat 70680
attatgttat tgatgtcccc taactataat acaagtaccc ctattataac aatatacaat 70740
acctacgcta ctcctattcc atgtaagact acgcttattt acataacaac taactaacta 70800
acaaaatagt gaagcaaaat cagttacatc tttcttacac cacaaataga gaatatttga 70860
acacctagac tctaaatgag aaatgaattc tttttttccg gggaaccatt tctctctaac 70920
caggtgttcc agaaaaatac aactagacac tgcattccag tagaatctgc ttcccatcac 70980
taaagtctta ttataccagc tatttaaggc atgtattgtg cttctgcatg acaatttatt 71040
ctcagaaata aacatagacc aaatctgctt gatgaaaatg caatggaaca gtaagtgatc 71100
aacagattca gcctccttca caaaatactg catatagtaa agcccctatt ttgtaggttt 71160
tcatgagtga gataggcacc atgatttgca gtccaggtga agaggcaacc tggggctgcg 71220
acagtcattc aaattatcct ccatggctaa tttacatggc ttcctccaat ttttagcaaa 71280
agagttttgt tgataagaat ggaccttggg cctaacttaa ccccaaaagc tagcttatga 71340
ggtgagaatt gcccaatacc atataaggag accaagacac ccattaccca ccgatgtggg 71400
acacaactca acaccccccc cccccnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 71460
nnnaaaaacc ccccccccca tgcccaggcc tgcaactaga gcgtggtcaa tataaatggg 71520
ggcccaacat cggtacaata aattaggatg ggcctagctt tgataccatg ataagaatgg 71580
accttgggcc taacccagcc ccaaaaacta gcttgtgagg tgaggattgg ccaagactat 71640
ataaggagac caagacaccc attacccact gatgtaggac acaactcaac agtagcatgc 71700
cctgacagaa aatgtcttgc ccttccagag tacagaattt gctatatgtt catcaatcct 71760
tacagtttca aactttaaat tagttccttt acatgctcaa actcccaatc attgagattt 71820
cttctcaata ttatttttta taaggtagat tttttctcaa tataatatca ataaaccaga 71880
agaatagcag tcaacaatag tgcaattctt gtgggtaatt acatatggtc aggtaattgc 71940
tcacgtagag gagtatcacc aaagcacttc tcggccacat tttaactctc ttgctatttc 72000
taacttttta ctaaacatta tcaaagaatc atcccatagc tttctagtat atttccacat 72060
agaaactcca tatacaccat ttgcactatc agtgcaccac tcttcggtct tcctatattt 72120
aacaataaca agattcttcc acaaatcatt tttgtcatca ttgaacctcc ggtgccattt 72180
catcagcagg cttttgtttt gaagttctaa aatctttgag tccaagtctc caaatttctt 72240
atcccagcaa actgtaccca acttgatcaa atgaattctc cgttgtcttg acatccttcc 72300
cacaagaaat tgcttctcaa catgtccaaa ttgcctttcc acttttgagg catgggaaat 72360
aaacacatat atgagtagga atctcatcca acacgttatt tattaatgtt aatcaccctc 72420
caaaggatat atacaaattc ttccagggtg ccaatttctt ttcacatttt caatcacatt 72480
tgtcatatat taacatccgt tcctttagca cccaagggta taccccaaat atgcggtagg 72540
aaagcatcca attttgtagc caaagacatc tgctagcatg tgtataacat ggtcaaaatt 72600
gacagatata gcttgtgcat tacatgtaac ccagctccta gtcaaaaata tgtaacccag 72660
ctatagcttc aaaggttaga tgtggcaaat gactgcctac cgataatcgc caaaataaac 72720
tcttgaagtg gtcacattaa gaaatatctc tgacttggga aatgtgccta ctttttcatt 72780
caccttccgg cacccttccg gtggaatttc actccttttc cggtgaattt cctccttcgc 72840
ataacatggg ggaaaagctt ttctttattt caggtgacaa gtcctatgag cttatcgaca 72900
tcagtgaaga caatgaaagg tggttcttat ggatcgaaag gggcagtaga tttacaagta 72960
aaattaagat tgatgaggac aacatcagat gggtatgtga gcaaatgtac caagcttcac 73020
ggggcgccgg gaatctttac aaaaggtggg ggagaaagat acaaacctat ttatacaggg 73080
ggtatcaaaa ttacaatgtc tatggcagat tcatcagaat tgaaacttgg gttggagaca 73140
ggaaatttgc aatcataata ccagaaaacg actacaacag ggggtgggga gatatagcag 73200
gaagaatatt acaatttttg gggaagcctg ccaactacaa gttcaaaaag tttgcagatg 73260
tgcaaaagag atcctttcta gtggctgcaa agattcacca cacaagtcaa cgagcaagaa 73320
gatgtagtgg ctgctactgg agatgttgct gctgccgatg aaagctccca gtttctatcc 73380
aagtgcctga ttggttgctt caacgaccct ttcaatcaaa gccccaaagc tgaagtcatc 73440
caaaaatggt ttatcacaag gtggaaagta acagcaggtc tcatggtcac tccgatggcc 73500
cataatttgt tcctcttcga actaccatct agacaggaag cagctagggt aaaagcaggg 73560
gattggttct ggaatggtag acacttactc ttgagtggtg gttgccggaa tctgggtcat 73620
cttcaaccaa aggtgtaatg ggacagaagt ggatcaaagc ctttggaatc cctctgcatg 73680
gctggacatc aaaaaccttc agtttcataa gagataagtt cggaggattc ataggcaccg 73740
atgaggacat gaaaaacagg gcacatatgt tctgggccag aatctgtgta aaagaaaaag 73800
agatgagtta cccagggatc gtctagttaa aaataggcaa cttgagctac aagatttcag 73860
ttttggagga cgtactcaca aaatctgcaa ttttcggcga ggtttcagtc gccgtcagag 73920
tagagaaggc ggcagtctct gataagccct aatcgagtca agcgaaggaa ccaacgaaca 73980
acccagtagt ctttaaccaa aatagaccca tcatctttaa ttcaaaagag gctgacgtgg 74040
ctgcctcaaa ctcggggcat acgtacagga tgccagttgg aggcacatta aatcaaacgg 74100
tggggtcaaa gagaggactc aaaatttggg cctcttagtg gaccgtgaat attacaaaaa 74160
gggcctaaaa ggcaagcatg cacagagggg aaaattaaca aagcaaaagc aaatctggag 74220
agcaactggg cctaaaattg acccatgtgt tttgaatccc aacccctaca tctctgtaaa 74280
ttattttgac ccactaatga tagaactaga agcctccttc tcagaagggc ccagtgttaa 74340
accttcttca atgacgcact gcgactcaga ggcagatgat gaaggagaaa aggttctgca 74400
aaatatttgc aggaaaatgc cacaaccaac tgaagctgta gacagttcag atgtcgagct 74460
ctcttcttgc gacacacttg ctctcccatg gtatgaacaa ggctcttcaa acatgcaagt 74520
aatcgatacc ccaaatatct acaagcatac aagatggaca aaggttgtga tgttaaaggc 74580
atgcaaggct tttggggtta acgtagaagg gtttgagcat gagattatgg gcatcatcct 74640
ccggatggat caaaagaggc aaatgcagtt gcagaaacaa aagtcacctt ccggagaaaa 74700
aaaaaaaagg gtaagaagaa gcaagaaaca gaactggaaa gactaaaatg gggcctaaat 74760
tacgagggta aaaggaaagg ggatatggac aggttttaca aagctttttc tggatgaatg 74820
ttaaaatatt aagctggaac gtgcggggat tgaatgaagc agataaaagg actacaactt 74880
catcactgat taagaagtgg aagccagata ttgtttgttt acaagaaaca aaaatagaag 74940
aattcccagc atcatggatc agacaaatat ggggcaatcg ttgggtagag tgggcagagt 75000
tgaaatctgt agggaacagt ggaggtatta tcatcttatg ggacaaaagg caatgggcaa 75060
acagggatac tcatcaaggt tagtaaactc tttctcgcat gttagaaagc ttgcatgaac 75120
agttcagatg gtgttttaca ggagtgtacg ggccacacac aaatcctgaa agagaggaac 75180
tatggttaga acttgcagca atcagatctc tctgaaatga gcaatgggtt atagggggtg 75240
atttcaatgt ttgtaggtat gaaaatgaaa gatacaattg tgttagaagg tccagggcca 75300
tggtgtcctt ctcagacatc atccaagacc taggaattat agacttgcct ctacaaggag 75360
cttattatac ctggttcaga ggtgaagact cattgcaagt ttcgagaata gacaggttct 75420
taatttcccc tgaatggtgc gacagtttca aagctatcaa gcagctagcc ctcccaagag 75480
tgatctctga tcataggccc ctactccttg agtgtggtga ctgggaagcc accccccttt 75540
tttattgata aggtaaattg tattaatcaa aagggagtga actcacgtat acacgaagta 75600
taccaaagac gtagagaatt tacatcagaa catgattctc tacaaaagac gctcaatctt 75660
ctatacaagt atgggctaaa tgagtgcaca aaaaagcgac caaagataaa agactattca 75720
taagatgtga aaaaggagat tcaatctcct caaaagcttt cctatttctc tccccccata 75780
ctacccacat gagagctaat ggggcgaact accacgcctt ttgctttctt cttctacaaa 75840
aaccgcccca actatataac atttccttta cagtgctagg catcatccat tgaacaccaa 75900
aaagattcag gattgccctc cacaaagcag aggacacagg acaatgcaac ataaggtgat 75960
caacttcttc ccctgagatt ttacacatgt agcaccaact aacaagtgta atttctctct 76020
ttcggagatt ttcagcagtc aagatcactc tcctcgccgc tagccatgca aaaaagcaca 76080
ccttcgtggg cgcccaagga atccagatcg aggagtatgg aaaagtggtc tcctctctca 76140
ccaacatact ctggtaaaag gactttacgg tgaacaaacc atcgccacgc aagccccatc 76200
tccaagagtc gcaggatggc tggagcctgt cttgcccgta tagcagtgcc aacaaaactt 76260
ggagctccgc aatctcccaa tgttgcatgt tccttctgaa tgagaggtcc catactaccc 76320
ccttcatact ccttgcgaat ctgttggacc atcagttctt ctggtttgaa actctgaaga 76380
cgtgggggaa ggagaccctc agagtatcct ctccacacca cctatgattt taaaagctga 76440
ttctccttcc atctcgcacc ctgtaagtga tgttgccact gaatgcttcc caatttttca 76500
tgatgctcct ccacaagcca cacccgaaag gcgttgtgat cgccttggtc ctccaacccc 76560
ctcccgttga atcgtacttt tctactatga cctcactcca tagagcatgc tcttctacct 76620
cgaatctcca cagccacttt cccattaaag ctctgttaaa taccctaaga tctttcactc 76680
caagtcaact ccacttcttt ggggaagtga ctgtctgcca attcaataga tgaaactttc 76740
tagttccatc tgccgcatcc catagaaagt tcctttgaag tcgctccagt ttttctgtga 76800
tgctcaccgg tgcttgcaac agggataagt aataggtggg catactcgat aaagtgtttt 76860
tgataagcac ctccttacct ccttttgaca aataccgttt ctgccaccct gctaatcttt 76920
tttcaacccg cttgatcact agattccaaa ccgtagtatc cttatatgaa gcgcccaaag 76980
ggaggcccag gtaagtaatg ggaagggagc ccacattgca tctgagaaca caagacaagg 77040
catcaatatt agtaacctca cctaccggga aaatctcaca cttgccgatg ttgattttga 77100
gtcctaatac taactgaaac cactacagga cctgcttcag gtaggtcaac tgatctatat 77160
cggcatcata gaaaaccagt gtgtcatccg caaaaagcaa atgtgagact cttcgggcac 77220
tgagcacccc aatcggagct gagaatcctc tcaaaaaacc tctgtccgcc gcacgataca 77280
tcattttgct cagagcatcc atcactagaa tgaataacat gggggatagg gggtcacctt 77340
gcctgagacc cctggaactg ccaaagaaac cacacgggct accattaacc aggacagaga 77400
atctgactga ggaaatgcag aacttgatcc atcccctcca tctttcccca aaccccatct 77460
gcatcataat gaagtccagg aactcccaat tgacatggtc gaaagccttc tcaaggtcca 77520
acttgcatag taagccgggt tctctatttt tccttctgga gtctacaagt tcatttgcca 77580
ccaaggcagc atccaggatc tgcctacctt ccacaaacgc attctgggag gacgaaacag 77640
tcatgtcaag aaccttctta agtctgttgg aaagcacttt agaaataatc ttgtaaatgc 77700
tccccacgag actaataggc ctgtagtctc tgatacaaga tgcaccttct ttcttaggca 77760
caatagtaat aaaggaagca ttgatacttc tctcgaaaac accattcgca tggaagtatt 77820
caatggcttc catcaactcc ccattgatgg tggcccgggg gccttatcac cagcacaact 77880
cgacacagcc tcgtgcaccc cctcttattt caagttcgaa aatatgtggc tacaggcaga 77940
gggtttcatt gataaggtta aaaactggtg gcagagctat gtgataggag gcaacccaga 78000
ttttatactt gtgcagaaac tgagaaggct caaggcagac atcactaatt ggaacagaga 78060
ggagtgtggc agactggaaa cacaaaagac taaactactg gaggagctag caatgctgga 78120
gcaaacaaca gagaacaggg cccaaacaca ggttgaaaag gagaaactaa tgcagataat 78180
agtggagtta cagaaaatag caaaggttga ggaggtctca tggagacaaa aatcaagatg 78240
tctatggctt aaagcaggtg atagaaacac taagttcttt caaaaaatgg ctaactccca 78300
cagaaggaac aattatatta acagattgaa gataggggag gaaattactg aggaccaaga 78360
agccatcaaa actgaaatcc taagctttta tcgggggtta tattcagaga gtgagcaatg 78420
gaggcctagt gtcaactttg aaaacttagc caggatctcg atggaggaag aagtatggtt 78480
ggaaagagct tttgaagaag aagaagtgat ggcagccatc aattcttgtg caccagataa 78540
agccctaggg cccgatggct acacaatggc tttttaccaa aaaacttgag aatttatcaa 78600
gccgaacatc atggcagcaa tcaactattt ccaccataac tgtcatatgg taaagtccag 78660
caatgcctcc ttcattgcac tggtccccaa gaaaaaaggt gcagtagagc tcaaggattt 78720
tagaccaata agccttattg gaaatgtgta taagatagtg gctaaacttc tgcagaaaga 78780
atgaagacag tgatggggaa gctaatctca ggggaacaga atgcattcct aaaagatagg 78840
cagataactg atgcatcact tattgcaaat gaactgctag atgagagact taaaagtgga 78900
gtccctggaa ttctatgtaa actagacata gagaaggcat ttgatcaagt caactggtcc 78960
tatcttctgt ctactctaag gggaatggga tttggtgaaa gatggataag gtggatcaag 79020
ttcagtctaa ccactgtcaa atactcggtc ctcatcaaca gatctccagt tggctttttc 79080
tcccctcaga aagggattag acagggagac cctctctcac cttttctctt catcatagca 79140
atggaaggtt tgagcaaaat gcttgataaa gcaaggcaat tggaatggat tgaagggttc 79200
aagataagca acaactcagg gatttcaatc tcaatctccc atctgctata cgcagatgac 79260
acactaatct tctgtggggc tgagagactg cagctgcagt accttaatct aacccttctt 79320
atttttgaat ctatttcagg tctacgtatg atatatcctg tcaatgtggt acctgactta 79380
gatgagccgg taggtataat gagttgtggc attggctcat ttcctactac ctaccttgga 79440
ctacccttgg gagcaaaaca taagtcagtg gaggtgtgga atggtgtgat tgagaaagtg 79500
gagaaaaggt tagcaacttg gcagatgcaa tatctctcaa tgggtggaag ggtgactctg 79560
atcaatagtg tcttggacag cataccaacc tacatcatgt ccctcttccc tatgccaagt 79620
aaagtccaaa agcagctgga caaattgaga agatcctttt tatggaaagg taacagtgaa 79680
ggtcacaaat tccatttggt gaagtgggca actgtaactc aaccaaagtc actaggtggt 79740
ctgggcatta gagatctttc aaaacacaac aagagtttgc taatgaagtg gcattagata 79800
tatgggcaag aaggcacaag cttatggaaa gaaacagtga aagccaaata tggtcacctg 79860
aataattgga gtaccagaac cacaagagct cctcatgggg ttgggccctg gaagcacatt 79920
aacagcctaa aggaagtctt ccaacaagaa gtatccttca aagttggtaa tggagcacat 79980
gtgaaatttt gcaaggataa gtggctaggg aacttcacac ttcaagaaac ctactccact 80040
cttttccacc tagctactga tcctaactca acagttgcac agaatagatc caacaacact 80100
tgggaggtcc ttttcaggag aaacatccaa gactgggaga tagacgaagt gcttgatcta 80160
cttggaaagt tagcaaattg tacaacgagt atccagcaca cagataagct aagatggagc 80220
acttctaagg aaggggcata tacagtgaag gcaggttaca ataaactttg tgctttgaat 80280
gaagttattg acatgtggcc ttggaagcta atccggaaaa ccaaactgcc tacaaaggtc 80340
agctgttttg tatggactac tcttaaaggt gctattttga cacaagacaa tctctgtagg 80400
aggagcttcc agattgtgaa tagatgccac atgtgtaagc taaactcaaa atcaatcaat 80460
cacttatttt tgcattgcac agtggctact gatctttggc acatgttctt ctcaattttt 80520
ggtatcagct ggacaatacc tcagaacatt aaggaagcag ttgaaagctg gagcttttgg 80580
aaagtcagca aggccatcaa aagtatctgg aaaatggtcc ctggttgcat attttggtgt 80640
ctttggacag aaaggaatcg aagatgtttt gatagcattt caactcctat tcactttttg 80700
aaagctagat gtctagtgta tctttttagt tggagtaata cctcccctgt aaataatgtt 80760
attccctttc tagacttaat tggctcaatg agcctagcct gatggcccat ttttttgtgg 80820
ttagctccct atgattagaa tagcacatga tgtactggag ctaacatccc ttcttttgta 80880
cttattgcat cttcctgatg ccagcaatac aacacaccag caatacaaca ccttacttca 80940
tcaataaaag gttagacaga tagctttcag atgcagcaat aggtcttcat cagcctcaca 81000
taatcagcgt gtcatctgca tatagaatat gtgacacttc aacactgcag aggagcatgc 81060
atttggaagg tggtagcaca gaaatatgac accatggaaa ggaggtggat agccaaaaac 81120
atcattgttc cttttgagtg cggccttttt aaggaatatt aagaaaacat atatttagtg 81180
gttgtatctc atttaaggta agagagaaac aggactttta ggggacaggt agtccaggga 81240
caacaggctg aggatcattt ttccaaacat ctgtagagat tcatgccatc tacagatgac 81300
agtccaacaa gtctggatat aacatgaggg aagtgtattt gggatcttag attaaaaagg 81360
aaccttctaa gatggaaaga cgacaaatgt tgaaaatcta cttgaaatgc tctataaaaa 81420
gactttactg ctagacaacc aagattactg gaggtcggag ttagggggtg gtcaaaggtt 81480
agagtcggat atccgtaaag agctactatt gtaagtttct tgctagacaa aagttgggtt 81540
tccctcgttt tccagtttgg atcccaagga ctccaagaaa tgtgcgcttt ttttgaatgg 81600
ttggtggcta aaagagcgat tttgagaacc gaaaatttga agaagaggag aatcacatgt 81660
cagttggtat ttcatgtgca aagattctgg agatgacatg gatcatatcc tactgcattg 81720
ccaggtagca ttacgttagt ggtagagtat taagatggtt cgagatacaa tgaaccgtgc 81780
tggataatgt gaaggctggt tctagttagt tgggtctaac acggggcatg gaatgttgct 81840
ctattagcac ttatatgggt aacatggaga gagaaagagc agagctctta aaggacaaag 81900
cttgcttggt acgtttaagg aatagcctct tgtttttaat gtgtttttgg tataccaatg 81960
agattccttg ttttatagaa gaagattggt gtctttccta aataatcaca tctttatata 82020
gattctctat tttttacttc ctttggcatt aaaaaaggca gcccggtgca ctaagctccc 82080
gttatgcgcg gggtccgggg aagggccgga accacaaggg tctattatac gcagccttac 82140
cctgcatttc tacaagaggt tgtttccttt tgcatatggg agctttttcc tttttcgtaa 82200
aattacactt tacttgataa ttaaataata tacccaaggg aatggtttag tggccaatga 82260
agtgggagga gaatcatgag gtctcgggtt caaatctcaa tggaggcaaa aaaaactagg 82320
tgatttcttg ccatctgcct aaattttgga agatagagtt actaaatgtt tgtgctggag 82380
gtaccaacta tcccataaat tagttgaggt gcacgtaact tggtccggac accaccggaa 82440
taaaaaaaat aaagataaaa ataacaataa tagtaatatt ataaaatagt atgagataag 82500
gcgaagatcc tatattcaag ctatgttcct cagactcttt acaaaatatt gtcgggtgcg 82560
tattggatcc tccaaagtag tgcattttcg gaggatccga aacggatgca acagtatttt 82620
ggagagtccg agcaacatag aattcaagtc aatacaccct tataaacaag aattttcacg 82680
tgtttgatcc caaaaaaagg tgctttagcc tgctcgcctt ccaatcaaag aggctgagag 82740
actcgaaagc ttcacttcat tcgcttctcg gaagctgcac aactctgcac gtgacaaatg 82800
ctgagtctca ttgtcacttg ttatcaaaaa caatttcctt gtgttcaatc ccctgaagaa 82860
aaagggcgca agcccgcagt gaggaaacat taatgtgtcc cttctttaac aagcttacac 82920
tttttgagtt ggtcaaacta ttcaacatca tccacctcgc ctttgaatga tatatacact 82980
tgaaaaacct ttatttaata tatattacta taaatttcac acaaaccacc gcacagctca 83040
actatatgcg tacacacaaa taattattta tatacacaaa taatctataa aatatttctt 83100
tatctatttt gacgaggagc tttagctcaa cgataaaagt tgttgccacg tcactggaag 83160
gttgcgggtt caaactactg aaacaacctc ttgtgaaaat gcactgtaag caggggcgac 83220
tctaaaggct cgggcagtga ggtcgttgcc ttaggcccca agaatttgaa ggccccaaat 83280
ttattttaaa ttattattat tattactcta tattatataa tttatataaa taattactat 83340
aaagaaaagt gttacagtat attttttcat tattagattg aggttatttt ataccaataa 83400
atttataaat tatgataatt ttcttgtcag ttaggggtag gtataaacct tcattcactg 83460
attaattagt atatttgttt cattcttcaa ttttaatttt atccttttta tatatgaact 83520
aagttatata tatcgacaac ataataaata ttttttacaa tgttctctaa aactacatga 83580
atacaaaagt attcatggac cgtcttttta gagtaattcg acatattata ttaggttgtt 83640
tacaatctat tttaaatatt caccaataag tgctacttaa tagaatgaag tataattatt 83700
gcttaattga tcagaaggag taaatatttt tgacaccgtt aatgctcaaa atttaagata 83760
ttacgttatg tacgtttatt tctttttctt gtttgtgatg atagccaaat caaaatttgt 83820
gcaccagtcc accactttat tttttgtgct cttcttccta ttttgttgtt taaaaagcaa 83880
attttattgt tagtgtaaat atggcagcct atttctctaa atttttaagt tgggcaaact 83940
atttaacatc accacaaagt tttagttgat agtgtatgat tctataaaat ctcacaaacc 84000
atgacacaac aaaaatatat gtacaaaaat aatcttcaaa atatacattt agcaattttg 84060
cacccacaag agcaaagaac ttactttcta gcaatttttc tggggtcttt ctctggtttc 84120
tgaactgaaa caggggaatc tgtgtcgcca ttgagagaca gagcagaaag ctgctcagtg 84180
atcggtgaag ttgcagcact tcgtggactc tcagtgtcgt tctcaaaatc gccgccttcc 84240
atgacggtgg cagtggcggt ggcggtggcg gaagtaccgg tagtgtgtcg gcggcagaaa 84300
aaaaggtgat tgactttcag ttgactggga gaagtgaatg ttttcttttt gtttagctta 84360
cttggagaag tgggtttctt caggtgcgcc ttttgaaaaa gaaaaaatgc tgacactgtt 84420
caatgatgta tcaaacgcat ctcacttcct accaaactcc tcaccttttt tattttggtt 84480
tttgtctatt tttttttaat ttaagtataa agtcaccata atataatttt tgttacgtgg 84540
tgaggctttg gattttcgag aacatgactt ttgataggaa gttatgaaga ttgagtatta 84600
ggattgtagg ttaggaggta gttgagtgta ccttacttcg tacctttgtg agactagtat 84660
ggtagggttt tttaccgatg tcagctagtg gcaacgttgt gtcttactac tcttttattt 84720
tccatagtgt cgcgtctatg tactgtctat cacgtttact ttgcatctac tttctcattt 84780
ccatgatgtt attttttcat attgtctctt ttaggcttct tgagccgagg gtctttcgga 84840
aacagtctct ctactccctc ggggtaaggg taaggtctgc gtacacacta ccctccccaa 84900
accccactag tgagatttca ctgggttgtt 84930
<210> 64
<211> 27271
<212> DNA
<213> Nicotiana tabacum
<220>
<221> misc_feature
<222> (1406)..(1417)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (10706)..(10706)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (15092)..(15092)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (18008)..(18008)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (24423)..(24423)
<223> n is a, c, g, or t
<400> 64
ctacaagtgc tgcaatataa actaaacagt tagaaatagt aggataatat tggtcagata 60
atttatttgt agcaatatga aattgttcta aaaaatctac aagcatttta acactactcc 120
aatcttgatt tgtaaggtgc tcatcatcat catcatcatc atcaccatca cctacactag 180
cattatacgt tgcgcttatt gggttcctat attcatattc aataactaaa ctttcataca 240
tgtaatttca tctagtcgga caaggtttag gaacttttct ttctctaagg ccaaattcat 300
cacatttttt aaaatagtct ctaagtctac ttctacggtt tgaataaaaa agccaattaa 360
gagccatttt aaccttttca atttctacat ctaaaacttt cataccagca ccgacgatta 420
aatggtaaat atgaaaaata ttactaaatg aaggatttag tgtagttgta agcaagcata 480
tagcattagt gttactagaa gcattatcca ttgaaatcga cataatttta tctctaatgc 540
aaaaatatct acaaatatct gcaactgtgt tagcaataaa cttacctgtg tggtgtgaat 600
taattatttt ataagcaata atgcgctttt gcattatcac tcctcatcta tccaatgact 660
tgtaacagtt atataatcac agtcattacc acttctacca atatcagtag taatagcaat 720
gcgacaatct atatgagtaa ataaatagcg gaaatattgt tcatattcat gtttatattt 780
ataaatatcg ctctttacgg ttgcgcgagg ccatccttta taagtaggat taaaaactct 840
tctaatataa tgcacaaaat gagggttaga gggaaaacta taaggtaagc acataacagt 900
aaccattttt gtcaattctt cacgatcttt atttggatca taatataaaa tgccaccggt 960
aacagtgtta atttccggtt gaactagatt tgaaactagg gttaaccgta ctatctacac 1020
ttgtcctctc ttacacagct ttcatttgta aaaatctagc tttatctcta gggtgtttca 1080
atatgtgtct agtcaaacta cctgtaccgc tacggtctcc agtaaattta tgaactagtt 1140
gagacccaca agttttacat ttagccttat tttgttctct tagttgagta aaaaaatgtc 1200
aaacaagaga tgtttcgggc cgtttagaag gtaggttgtt tattaaaagt aggggttact 1260
ataggagggt catgcggggc atcagttggg ttattaacag gactagtagg tgtatcatct 1320
aaatccggtt gcgtttcatc taaatcatca ttttcctcat cattttcaaa gatagtttca 1380
ttaggataaa gagcattcat aacttnnnnn nnnnnnntca ccaattttag atttttcctt 1440
acccttacca ccaaaaatat ttttcaaaga aaatgccata ttaattataa ttatactaaa 1500
taaaactaac aaaactatga tattaaaact taagagttgg aacgagttta ccgaattgac 1560
gaacaacttc ttgaaaatta aatatcgttg aagacttgaa tacttcaatt caccaacttc 1620
acaatttttc acgaaattgc aataataaag taagcaatta tagaagaaaa ttagagagag 1680
attaataaat ttgtgagtaa aaatgaaaga aagggggtat ttatagttga gaattgggaa 1740
aaagtgtaat tataaaaagt ttgggattaa agcaaagttt gggggccaaa tggctatttt 1800
ttaaagtgca taacgaacca attttgaagc ccaatggtca gattttaaaa tatagccgtt 1860
gggcatttcc gttgggcccc gtctggcccg ttgggcccgg ttgaaccggc ccaagcccgc 1920
ttgccggtcc cgggcttaac gatcccgggc tcacgggcta tttgtgttta accgggccgt 1980
cacgggtttt tgcaccactt aagctcaggc ccacttgaac cggcccatta ggcccgtttg 2040
gaccgcggtc ccgagccggt cccgagccca gaccggccca caatacagcc ttaacctcgt 2100
atctaggggt gtcaatgcat atttaaaagc cgactaaatt gaccagaacg tactgcacca 2160
aaccaatttt tagatttctt ttaataaaat cgtaggtttt tctataataa tgacaagttt 2220
tttgccttct ctctaggaat tatgacttgc atttatgaac ctattattat gaagttcgaa 2280
ttcatatatg tttttaacca ttaaatatct gaaattcatc aaaaagttta atcagaattc 2340
acgttgctga atacttatta tttcctaaat attactgaca aaaaatttaa catttctcta 2400
cattccttaa gaggttagct atctcacctt ctatttggaa tagttaatcg taccatttta 2460
gtacaaaatg gttattgaaa ccaataacta cccattacca aatgggggat aaaataaacc 2520
ggcattttat tcagaagatg aaatttctta catcaccaac caaatggccc ctaataatat 2580
tattttttct ttttaaaaag aaaaattaat ttgaatcgta cagattttga agaaaaagaa 2640
aaattaattt gaatcgtata gattttgaag aaaaaagaaa tttattcata tcagatttat 2700
tcattctttg taaatctttt tggattttaa agaatttgaa tcgcatagat ttttgaagaa 2760
aaagagacac gtcgaaagaa gcataacaca ttttcaaaga aattaagtcc cataagcaac 2820
ctataaaaga ccacaagaaa taaatagata actatcatta tcttctagat gtaaaggaat 2880
aatcaccaaa tacaagtgtc atttaccaat ttatagtcaa agaattctac aactttctca 2940
ataaaatgaa gcaaatatta atacggtgtt atggtaagat ggatagaatt cctttaatct 3000
aaataagagt ctttaattcg agtcgtgaaa taaaaaaatt ctgataagga gcgttttttt 3060
tataatgaaa ctaattaagc tccagaatag tatttacaca acatgtgata tgttattaag 3120
ctcatgttat aagttcgtac tctgacacaa acaaaagtga tatataagtg cagaaagaca 3180
gaagggcgag tccattagcc atcattgagc ttcgatccat acgtcattaa ccctcgaaag 3240
tttctccatt gcgcagataa atataatatg tgaatgtcct ttaatacaat tatatatgaa 3300
gtaatgaaag catccaaaaa cggatatcct tcgaaattat aatatttaca tgtataatgt 3360
ataatttgga aaaggacaat catgaaagag tataataatg ctcccaaaag aaaagtctta 3420
acattttaat tgtcaaaatg atgagtttat attacagaaa aataatacac aggtatgcag 3480
cagactcaaa taccctaaca aacggtttag ccatgaattt aattcaacta ggtaacacct 3540
tgtttagatg attgttacct attatattat atcgtagtgt taatttaaat ttaatattta 3600
ttttgattgt taaattttat tatattgtat cgttaaatca aatgttacaa tacaacgaaa 3660
actatcacgg acaaatttag tgtggtcaca ttgttacatt ttttttctct catcttgccc 3720
tttcttatta ctaaataatc acattttatc ctctgcatat tgctggcgca tgacatcata 3780
aaacgacgac aaacaatata atctattctt gtatatatca aaataatata gtacaataca 3840
atacaatatt atacgataca ttatgaaact atacataaca accatccaaa caagctgaag 3900
gatagagtta aaaagaactt gtttaaggat aaaaatagat catcaaataa taaggcaaca 3960
tgagacaaag aaataacata ggtaccccac aacaccaaat ttgttcataa aatgagcatc 4020
tttattgtca cataacaatg aaaccaaata atacatcgca ataaatttta aatgacaatc 4080
aaaacaaaca tcgcacttga aataagtgca cagtacgaaa ggaacacaca ataagggcag 4140
aaaccaaaac atatgaaaat tttgtaacct gaagttgcag aaaagcaact aaagctaagc 4200
atcagatgca cattccttca gcaatttgag tacatttttg caggccacct tctcggccat 4260
ttttttgtct cgttccgagc acgtgaactt gtgactaaca ccgtcagctt caacctctac 4320
tgtaatatac gccacgccat tcacacgtga gacaacattc ttcttcttta tataaccttt 4380
ctggtcacat agttcactca actctctgac tggatggagc tttactgtat ccggtgtaat 4440
caacggttcc agaagtgttc gtacgctctg aaacacaata tctttgttga agccagaatc 4500
aacaaagatc gccccggcaa gagactcaat aacatctcca agcacctaca tcgaaccaga 4560
aaagcaaaca agttaataaa cctaaaatag aaaatcaaat tagattattg gatactctat 4620
ctgtcccaat ttatgtgata cactttcctt tttagtatgt ccaagaaagg aatgtcacct 4680
ttctataagt agaaacaatt taacttttaa aattttcttt ttaccgttaa tgagatgctt 4740
tactgccaca ccaatgtcta aggtttgtct tagaatttag accacatatt tcaaaattct 4800
tcctttctta aactttgtgt ccactcaaat tgtgccacat aaattgggac ggagggagta 4860
gtattaatcc acattgatct taagttgctt ccgtcaattt tttccttccg tttctaaaat 4920
ttatggtttt cagataaagt gttatttcta actatgaggc aagtatgcaa tacctttgga 4980
aaagtagttt cggactccca tccgaaagtg gacaccggat ccagtttctc aaaattcaga 5040
acagtattaa ctatctgtct ctgcagatcc tgtgaagcat gaagaatgtg cttgtgtagg 5100
ccagccctaa cagcagcttg agcgtagcat tcattattta cggaggcaga cctcaaatca 5160
gtaatgagtc ctggagacag tcccggatat ttgaaataca gatgcgctgt aacagcataa 5220
tctagcactg catctccaag aaattccaat cgctgcatag ccaggtaaat catcagcagt 5280
tgaatcaaga aaggtaaaaa tgtacaaata ccaatggaag aaaatgattt ctttcattaa 5340
taacccttta tttaggaaac atcataattg acttttcatt gttcatataa caataagtaa 5400
acaagattgc taatggaaga ctagaagtca actggaaacg acatccgaag tactgcatct 5460
gtttaggata cttattctga gctaatggga catcacatgt gattgtaaga actttaacct 5520
taaaacagaa caggaaaagg gaatctgaac ttagaataag attccccgaa ggcaagccag 5580
cattccaaat aaaaccatga aaaattagct tgaaagaatg aaacagtgca cttttttcct 5640
ttgtcactag aagttttatg aagaatcatt aagtactatc gagccgctta ggtcaatgaa 5700
atgttcaggt tcacaagaca tagatccaac tatttaaaga ttcaatgata gagcaaccac 5760
gagacgcaga aatgcaatca acatcaagat ggataatagt tatttacgag actaacctga 5820
tagcatcgtg gaatctcagg tagcatgtaa gatccgtgag ttagagcctc tacaagcaga 5880
gaaggatcat ggaacttgta atgtagcagt gattccaagt atctgacatt aactagcttc 5940
tcagcattca tagggaagtg cctcggcgaa ggtgcatcta caaaatcaat gccgatccca 6000
agccatttca taaatgacaa agccgctact tccccgcctg agctgaggaa ggcacctatc 6060
agtgcctcaa caacatcagc taccctctta cttttcatct tctgccttcc cctactatac 6120
atttttactg aaggcatcag cacttcttca tcgaaattgt gaacttggga attatcacca 6180
ggaatgagcc accctttaag atcgaatggt tcattacgaa tgaatccctg taaagaaagg 6240
tatttattgg gatagcacac atcaagcaat ccagaagtgt taaataaata aaatgttaaa 6300
actcgactat aggaaatctt taagaatact cgggcatatt tacttattca aaggtccaaa 6360
aacagtctgt caaaattgac atgtcctacg acaaacatac tccaattgat gcactgacaa 6420
agtagacatt ttttacaaac ataggtaaca gcaatggcca agaactacta attaacatta 6480
taacaaacac tagacttagt tgtgtgggcg agggacagta gtaaagaatg ttcatacgtg 6540
atagttggca acctttaggt caacaaaggt ctttaattaa agtgcacgtg catataagtc 6600
agcaaagatt catatagaca tggagtttat gctatccaaa ctcctaacga aaacccaact 6660
aaattatcac caaggaatac ctaccggtat tttacgagca catccaagct tgcacaatgc 6720
agcattggaa ataattttgt ttttcttcac agtgagtaga ccctcgtgat gattttcata 6780
agtcttgaac agctgtatac tcgcagcata tttgagaaaa gagtctccaa gtgtctcaag 6840
tgattccaaa tgaaacttct cgacgcattt ctttgttgta attgcttcca gaacctaaaa 6900
taaccaagca aggaccacaa atcagctaaa acacaaggaa gtcgagaaaa agctagtcta 6960
ctgatggaaa ctcaatccct agagtatgtg taaagctcag agcttaagaa gactgaataa 7020
aatggagcta aatctgtgat gagataaatg cagcacatac cttagcagtt ggaataaaaa 7080
tgttttgagt gcactgatct gagtgcatcc ttttcaagtt tgaagccata atcaaggact 7140
caacccgatg catgaccgaa ggaagatatg aataggtata aagggtagaa atagagacag 7200
gtgacatgat gatggaacaa agttcaggag gcaattcaac agatgaatca gttgaatctg 7260
caaaggcgga caaggaggtc aaataaaaaa gaatagtgat tttccattaa acagtgaaac 7320
taagttctga gttctgcatt ataacagaag gagagccatt tgatcaacct ttagccttct 7380
gacttctaca tctttgaagg taattgtgta ctttgaaaat gcgtttcccc ctaagaagtg 7440
gttctccttc aaagcataag ttgatcccat gcctgtaaac cgcaccttac ttaatatttt 7500
gaaaccaaac attgatataa ggaaaagctg caccaaggaa ttagtagtta attgtacaaa 7560
ccgctttttg tagtattctt tgtaggtaac ggattctcca gttctctgtt ccagcaatga 7620
gttgcaatcc aaattatcca agaaaccggt aacgcagtac aaatagccat tatgaggcgt 7680
acagaccaat gagttctcca acatgcagct gcataccacc ccagttttgg tgttcacact 7740
gcgtttgcaa ccttgcgtag aacaacaatc aatatgctta tccccaagaa ctagagaagg 7800
aaatagcaca gaattcacac attcccaatt tatttgaggg ttttgagttg aacccaaaga 7860
tggaagcaaa agataatcag aaactgcaga accaacaggc agttgaactg cagccaaagc 7920
gtcctgcagt ttactcagat cgcggtcaag aagaattctg aatagactga cttgaaacct 7980
ctgacatcgt aaaatctgga gagagaatat aaaaagtatt acctactttt ttacaggtga 8040
caagtaaaga gaggataaaa gtcataaaaa ttatagtcac ctcttcagaa gtaagtctaa 8100
caactccact ataatttact tgaactagca agcttccctt atcaacatcc aagtcaaaag 8160
tcagtctttc atcgtcaaac ttgagccttg tcctaacagc aagtactatc ccacgaagct 8220
ggtaactgct gtaagagtca tgttgcaaat caactacgta gcagtagtac actgtttccg 8280
tatcattggc acaatgacta accaattctg gtggaaagta ctttgattct tcatcggtag 8340
agatttgaca tcctgcaaaa tataatgggt tagaaggcaa gtaactttag tccaaaaaac 8400
aacctataac caaaagtgag aattacccaa ttctttgatg atggcttctt cctccacgat 8460
atcaggaaca agattgtcgg tcaaggcacc ctcacgatga agttctttac aagcttcgag 8520
gcaagcaagt tgcttcaata ttttggtatt ccctttcaca ctaataactt tttgcagtgg 8580
gcaatttttg ggaagatgta gggtgcaggt ttctgtttcc ttctcaataa caaacctagg 8640
actgggttta tagtacctac aatcacattg aacggcggtc agtaatgcaa catttaatgc 8700
ctgaagtact caaagatacc aaatcattag aacgtggcaa ggattatgca gtacaaaccc 8760
atccgaagat agccttgagc aatagaagta taacaatgac acgctagaac tgagggtgac 8820
aactgctcca gttgtttcaa ctttatagtg caattcattt tgcaattcat catcaagagg 8880
tgaacacgga atagaagcat ggcgtaatga ttcttgccgc atgatctccc cactttgcat 8940
ataattttgc atgcgagtaa gagttgatgc atccccgcta ggaattaagc cagaaataga 9000
aggataatca gtccgttgtt ataattaaat cttccaaatt ttatcaataa tgattgcaca 9060
aaatcaagag ctgaagcaga tttaatcttt tcaatatgtg cacaatcgac aagagcataa 9120
atagaatgtt ttaagtgaaa aatacaccaa aaacaataat gacagaaccc tttaaaacat 9180
tcatatatca attatatcca agtgatagta tttgtatttg tgaggaggga atggatggaa 9240
aagcatacct cccaaccatc agaataaagt gtgagttctg ctttcgagct cgaccacgag 9300
actgtataaa gctacaaacg gttgctgagg gatcaaatcg aatgacaagg ttgcaacttt 9360
gaacatccaa gccctcttca agaatagaag tcgctacaat aatgttgacc tgcagcattt 9420
tgcatggaaa tgagactttc aatcttcaga aatcatctac aaaagtaggg aaaaataaaa 9480
ctggacttac cacacccttg cgaaattctt caacaatttt attttgaaca tttctactct 9540
gtgactgcag catagaacta tgtcctgctg tgtactcagt tttccaacca cttaattccg 9600
gaagcaactc atttaacaaa gaccgaagaa caatagctgt aatgattctc tcaacaaata 9660
tgatgcatct caaatccttc aggtctctat tggattggta aaaaaatgtc atcaacaaaa 9720
aaaaagatgt cagccagtga atcactaaat agaaaatcct atttccccac aagaactaca 9780
ttatttaaga catatcgcaa aatcaaggag caaatagagt gatagactcc agcatcacat 9840
ttaatcaaga taagatgaga caagaagcac aggattacag ttttaacatt aaaatgtgat 9900
cattaaaagg aatagcgtaa accattggta aactaccatg tgtaatgtta tttcaaaagc 9960
atagatgaaa gtacacagtc atgtaaggga gtcacttagg cagcataatg ctccctccat 10020
tacagttaga tggcttgcga gttcaatgac tcaagaattg aaatttttta gcactcatct 10080
tgtgcttcca aaatatttaa atccgtcaac acaaaattgc atgtcattct ctcgttgcca 10140
caaatcctaa gaaatctatc ggacaacttt tttttccatt tattctatgg aacatccaat 10200
agattgaatt ggcattgatg cttttaacaa atagagttaa tagtcagacc tcttacctgt 10260
actcaagaag agactctata agactattaa ctttggatgt caaatatcca gcatcaacat 10320
ttgcatgaat atcaccacca agtgaccaat gtgaacctat gtagagagag agagagagag 10380
agcacaaaaa aacaagaaag aagaaaacat atttacagct caggaaaaga aaatggatgt 10440
tgctaattat gataccagat ggtatgtgag ccgagaagac cttagatgca cccaaactga 10500
aatctctaac aatcgtttga gcacaaacat ctaattctcc ccatgaaaag aaggtgtctt 10560
cagaggacaa gaactcggct gcctgattca aaacgaattc atgttaggaa aatgatcaag 10620
accaaactga ttaatttttt tatgcacaat caaggaacgt atttaccttg aaagccagcc 10680
aaacacccag ctcactcaaa caaaangcag ctcaggataa gaaaatggat gttgctaatt 10740
atgataccag atggtatgcg agccgagaaa accttagatg cacccaaact gaaatttcta 10800
acaatcgttt gagcacaaac atctaattct ccccatgaaa agaagtcggt ttcttcagag 10860
gacaagaact cggctgcctg attcaaaacg aattcatgtt aggaaaatga tcaaggccaa 10920
actgattaat ttttttatgc acaaacaagg aacttattta ccttgaaagt cagccaaaca 10980
cccagctcac tcaaacaaaa tatgaaggac gaatatagtt ttgacaatct ttttcttgca 11040
gaaccagcac ttaaatcaga taggcttgac tttgaaatca aatcttcata ctgcaatgat 11100
aagaaaacac aaccagaatt gaaagagcaa aaatgtagac cccatatgtt gaacaagcca 11160
acatgattgt ttaatcatta caagaataga ttaaggttta gttctaagtt ccactatttt 11220
ctcagtgcac tacccatttt ccgctcgcac acaactacta tatagagaaa ggaagagcca 11280
aaataaactg aatgataaat gacactgtat ataagttcca agggggaaaa atatatgata 11340
taaaggggag taaatccaga gagaaagacg aaaggtatgt atgaacattc tattaataga 11400
aaggcataat ccattggctg aagaattgat gcttaccttg tctttcaact ttatcaggtc 11460
agaaactaaa ctaacaaaca atgtgcacgg aatatccaca tgttgatata tcttcagctt 11520
cggagttgag aatgggatat actctgccaa aacagattca ctgacacatg tgtatacctt 11580
catttgcaaa ggcagatcac aatcagacga actaaatata tatctacttg tgtctgtcta 11640
cttgcataca ttaaaaagac atgctaccca aaaaataagt gcaatgctca gcgatgtact 11700
gacgacaagc atcagaagca aaaagtttaa tgcttccaca gtccggtaat aaacacaaat 11760
tacagaaaga tacatttgca aaaatcatgt tgatgccatc accaaaaaaa cttctttaaa 11820
aaagaaaata acatgcttct atcctttgaa ctacatttaa gaccatattg catgacgtga 11880
atggataaaa ggagaagatt tagagagaac cttggaatgc ataagattct cgaggtcacg 11940
aatcatttcc caagtaaatt ccgcgctaga acctgcaata aaagtatgac tatgacaatc 12000
cacagaaaga cagtttgcta agagtgtgat gtaaaagcat ctcaaagggt taattgatga 12060
tgataaaatt aaatgtcagt aacctttagt ctttataggg gaagcagtca ttccgaatat 12120
tcttggaagt tgtgcgcttt caagggtgaa ttgacgatga taaaattcct gaaattaaaa 12180
tcaattcttt gacgaaaatt gttcaagcac cataataagt catgctcaag caggattata 12240
gtgggtcttt tctaaggtgc ggtaagattg ttggactagt tagacttaaa tcacatacgt 12300
acaaaagcaa tgatgtgagc attagagtgc cacatcgggt aaatgtacac actgtctact 12360
gtgcctataa aagaattcag ccataagaca tgtattccca tattctctca aatctctttt 12420
ttatctaatt cctgtattct ctcaaatctc tttttttatc tatcttttta caggtggtat 12480
gtgacatgca acacacactc aagagacagg aagtactgaa ataaaatact gttgaagaag 12540
tggtggtaag tatacaatag tagtcaatat ccattgagac agaaatccaa tgttgttgat 12600
aacattttgc tccattcttt cttctttatg atgtaagtag ggcactctcc ctaagacgag 12660
cacaaaaatt aaggtccagc atgataccga tagaagatga gtacaaaaaa tataccttca 12720
ttatgcaggc ataagggtgt ttgcctcttg cattgtgaca ttcatcaaat attagaactt 12780
tgatcatttc aatttttaag aaactatgcc tcaaagcagc aagtagtatt gcgggtgtca 12840
ttacgaggac ctgaaagaca gaaatgataa ttacttatca agcatccagg tatatatttt 12900
ttgataagga catccaagtt atatatatac aacttaagtc ctagcatgta tattctgaaa 12960
ctcaaatcta aaatatttgc cgagagccat gccaaaacaa aaaggattgt aaggcaaaaa 13020
aacagcagct ttgtttgcga attccctcgg agagaagcta ttgcttatac tccatagcca 13080
tttgttttgc cggcaggaaa aattttaagg attccattac cgaagttgac atgaaggatt 13140
taggaattgc aaagaaaatc cttggtatgg agatttcaag agaagacggt gttgtacatc 13200
tttctcagaa gaggtatatt gaaagggttc tcgagagatt caatatgcat acgttcaagc 13260
ttgtaagtac accattaact cctcatttta aactttcaga gttacaaatg cctcagtccg 13320
aggatgagat ggagcatatg tcaaagattc cttatgccag tgcagttggt agcattatgt 13380
atgctatggt atgcacacgt ccagatattg ctcaatctgt aagtgtggta agtagataca 13440
tgtccagccc aggaaagagg cattgggaag ctgtcaagtg gatattgaga tatctcaaag 13500
gagcttctag ggttggtcgg accttttgac taaatggaag tgcatgtcta ctcaagcaag 13560
tgttaataat atatcactaa agctaaaata tagttcacgc atacctcatg atcgtccacc 13620
tgtttttgcc atgtagcagc atcccaataa tcgacaccca tttctcccca atacttgccc 13680
actttcaagt cggtatgcat gatgagagca tctccttgct ttgtaattat caatcgcaag 13740
atcaacaaaa ttaggacaag tcaaatagac agtaatgcac ctaaaaccaa ggcccttaga 13800
aaaaacacaa actaaagggg tactcctcaa acaatatcac aagtcacaaa atgtggtaaa 13860
accgtaaaac taatgctcaa taaaagagtt ccacaaacta tagccagaag tgaaaaatat 13920
acacagtaag atcatgaagt ttaaggacta gattaagcta ggagtagtac ctgagccacc 13980
agaacaaccg tcgggaccaa gaaaacagct atgtatggag aaggctttcg aagaagataa 14040
gcatagcttc tcaaaagcat aatagcaata agggtctttc cagaaccagt ctccaaataa 14100
acaatagtgt tccgctttaa tgccgtctcc aatgcctcta actgataact acataacaaa 14160
atcatacata aaaaacacac atattacaaa ggttccttcc ttttctattt attttttcca 14220
actccatgat acattaaaag agaaaataaa tgtaaaatgc caaccttctt gcaaaaggca 14280
gagagtcagg gcagagctgt tggttttcag agactgtaac ttcagctggc tccattgata 14340
gttatctaca ttaacatcag accaaataaa cataaggaca ccaaccaagt aacaaagatg 14400
aaacagaaaa atctacaaga aaatgacaac cagttgatca tacataatag cagcctattt 14460
atcttacata ccctttttac cattttaagc aaacactaag aaaaaccaag gatttcacaa 14520
ggcacaaata attaaagatt taacaccatg gaaacaccca cttcataaaa aatccaagaa 14580
aactctatga gtaacaatga tgaaacagta aaactcctaa aggaaatgac aatcaggtga 14640
tcatacatta aaaaaaccac aaaactcctg catacccttt ttaccatttt ttaaaaaaca 14700
caaggaaaaa ccaaaaatca agaaaagaat accaataacc accaccacca ccacccctct 14760
aaaaaaaaaa aaagacatca caagtaaatc acatatgcat aaaagagtaa tctgaatgaa 14820
aaacacccag ttgaataaaa tgcataaaag agtgatttta tgaagaaaaa cacacataaa 14880
tagttaagaa aactcactgg ctagagttga attgcaggat tgtgaataaa atatttcaaa 14940
cagttttgag tgtttagtga agaagaaaaa gtaagagaga tacaagggaa ctatatgtag 15000
aggtttttag cttctatgga aaggaaaaat actctccccc accccaccac ccaccacccc 15060
ttaatcagag taactctgca acaccaccac cngatgaaaa gacagaatct ttttgaccta 15120
ttaaatatag gaaatccaat ttgaaggaat ataaatcaga actcctttaa tactgttctg 15180
tttaaattcc tctaaagaga aaagcactca gtatattcat ttgtttttta tttcattatt 15240
gacccttaag aatctgttta atgacaatag aatttcttga tctacggaac gaaatttgat 15300
aatgtaaggg taatttagtc attttgtatt aagaaaatgg accaccttaa tacggaattc 15360
tgtttctcgt cactgttacg aggaaatagg aataacgctg atggttactg ttaaggtgtt 15420
caaaccgaac cggaaaatcg caccaaattt aaaattcaaa cgaaaccgat taaaaaactc 15480
aattaagttt ggtttgactt gatttggtat tgagtaaaaa aaaccgaacc aaaccgacat 15540
ataaatatat aaattttatt tatattttca agactttata gtgaattttc ttaagaaaat 15600
gtagaaatat ttggatcctc tcatgtatta accttgaaag tagtaaatta acgaaaaatt 15660
attgttagat gactaaaaaa ataactatca cgtgttacta aaaaaattct ctcattagaa 15720
tattttaata aatcatatgt ttgtcaattt tttttccata tttactaaac atatattcac 15780
ttattaaagc tttatctata attttaacaa agtaagactg aaataatatt catgtaacaa 15840
aaaaactcga aaacactaaa aacccgaacc aatccaaacc gatatagttg gttaggtttg 15900
attttggtaa aaactaaaca aacccggtcc atgcacaccc cctggttact actattttgc 15960
ttcagtgtga cgtgcacgtg accgagaata atgaggggaa aaactaaaca ttttaaaagt 16020
tcaaaataaa gttggtttct atcaaaatat aattatattt atttgtttgg ctgttagtgg 16080
gcgtttggac aataagaatt tgaaatttca gaaaaaaata aaatattttt tcaagtaaaa 16140
atagtatttg aaaattagag ttgtgtttgg acatgaatac acaaagaagc taattttaat 16200
ttttgtgagt gatttgaagt gaaaaaattt gaaaaataat tttttgaatt ttttcaaatt 16260
tcaaaaaaaa atccaaagtt cagaaaatga aatttaaaat tttcatggtc aaatacttat 16320
tccgataaag aaaaaatata ttcaaaaaaa taattttttt atcgccaaac gggccttaat 16380
ttagtatgtt gtatgattga ctacagataa attgtcaaga aaatttgtaa tttatatcag 16440
agttaagtaa gttatttatc gtttaaaaga ggaataaata gaagtgcatc ttatcaagga 16500
ttataaataa caaattacta acaattaatg ctaatctcaa aaaaaccatt caaagagatt 16560
aaaagttgtt actattggac tatggaatag ttatacttcc attggcagag cacttggttt 16620
acacgcgtgc caatatttta cttgtaaaat ggcatcgaga aattaattac atactgactt 16680
ttcagcaaaa tttatcttaa aattaaataa agattatcac ttgattcaag aaaataatta 16740
acaataaagt cgagatcagt tgcaacttgc aaagaatgtc atgaattcct tttgggcgtt 16800
ttgacataag aattgtaaaa ttccaaaaaa tggtgaaaac aaatttaaag tgaaaatggt 16860
atttaaaatt tagagttgtg tttggatata aatataattt tgggttgttt ttgaagttgt 16920
gagtgatcta agtgaaaatt ttagaaaaca gctttttgga gtttttcaaa tttcgaaaaa 16980
taacaaaatg catcttcaag tgaaaattga aaattttatg aacaaatact gattttgaaa 17040
aaaagtgaaa aaattttaaa aataaggaaa aacttcttat gtccaaacgg gcttacgcag 17100
cgtatagata gtgtgacaat tgaagtgctt cgttttcttc tctttttgca ttttcatgta 17160
aaaaatttta gtgttatttc ttctaaaaca gtttgttaca gtaattggtt catagagtaa 17220
aaggagtagt acataattta ctgtaattgt taggcattcg aatcaaagat gtgatattaa 17280
gtaggagtaa taaatataca aatcaaacat attatggatg agcatgcctt taaacggttt 17340
ataatcctga tgcaaaatcc cgaaaaatct ttacactttc gaaattttat attattattt 17400
gatgatatgt atgatcaaaa tttatttttt tatttcctac gtaggtaaat atattaatat 17460
agttgttaga aaataatata taaatgagtg agatgattat cttagttcaa ataaagttag 17520
attaaatgaa aagaaaaggg aaaaactaca aaaatccctt gcgatgagct cgtgatacga 17580
gattaccgca ttggattcac cagcgtgaga agagcctggt ttggtcacga ggtctcacgt 17640
cagctccttt accattaaaa gaaaaaagat acgcaaaaac taaaatccaa gaaaagatac 17700
aaatccaact agaaaataaa gaagatttaa caaataagtc acatagaatc aagatttaac 17760
tcaatgtaaa taaccaaatc aacaaaaaaa aaatactaca aaaaagagta acatttatga 17820
agaagaaaca caaaattggt taggaaaact tactggcaag agttgaattg caggattgtg 17880
tacaaagtaa ttcaagcaat tttgagtaca atttataatc aatacaaaat cttttttcag 17940
aatgaaagag agagggaaat gaaaagacaa aatcttttgg cctattatat actagtaaat 18000
ccaattanta gttgaattgc aggattgcgt acaaagtaat tcaagcaatt ttgagtacaa 18060
tttataatca atacaaaatc ttttttcaga atgaaagaga gagaggaaaa tgaaaagaca 18120
aaatcttttg gcctattata tactagtaaa tccaattaaa ggcaaaaacc agaactcctt 18180
ttaatactat tctgtttaaa tttcataagg aaaaaaaaac taattaaata aatttgtttt 18240
ttatccctta ttaagccttg ataatatgct taatgacatg tgagtctctc gttgtatagc 18300
cggaattatg ataaagacaa gggtatttgt gtcaatgttt ataagaatat ggaccgttgt 18360
tagttgttac aagggaaaac gaaaagactg acgctactag ggcttgcttc cgtgtgcagt 18420
gcacgtgacc atgaaataaa agaagaaaaa ttaaattaaa catattaaaa ggttcaaaag 18480
aaatattgga aaattatatt tatttgtttg gttcttggtc atttgcatga atgacttcca 18540
aataatatat aatgacaagt tgttctaaat ttatatatga gttaagtaag ttattatcgt 18600
tttaattaaa actaaagtaa gggtatccgg ttgaggatta taataaatat cggatatcgt 18660
attacttata actaattact aaactaaaga ataccaatta aagagatgca tcataccaga 18720
tcatgcatta tttgtaatgt aattggcaga gcgcctggtt actcacgcga ttgtttttcc 18780
ataaagtggc attcagaaat taattattta cttttagaca ataataaact tgattttctt 18840
gaaataaata aaaattgtca caagattcgc tattttgcat cccaaaaaaa actttactaa 18900
agatgatatc aaatgcaagg aatgtgaaac ctttaatttg tcttagcata ggtggtgtga 18960
caattgattt tttttttttt ttactatgtg acataatgga ttaatttgtc tgttcctaat 19020
tagtgtttgg attctaagct tataatgaag gaaataagcc ttacgcggcg ctacttcgga 19080
ttagttaagc caataatctc ttatagtaga tgattaaaca aaaacaatca attttatttt 19140
ttaaatttcg tgtatagact ttaagtggta ctagtattgt tactccctct agtccacaat 19200
aagtgatcaa tttacctttt tattttggtc caaaataagt gtccatttat ataatcaaga 19260
aaaaattcaa tttgtttttt caaaattacc cttatgtatg tattcctaaa aagtctttta 19320
ctcctcacat taaattaagc tgcaacattt aattaagggt agtttagtca cactaactat 19380
ttttgtttag aatttagtat tttcttaatg ggtgtgccca aggcaaactg gtcacttatt 19440
gtggaccgga gggagtagtt actaatgacc attaattgtt tcatgacggt ataattttgt 19500
actcaaaaaa tataggagtt ataaatatac gagccaaaca taaatgtgta tgttgtgtat 19560
aattttgatg acttaagttt tttttttttt tttcaatcaa aaatgcatga aataacattt 19620
cattttgtgt gctctaccca tccaaattcg aaatagtagt atattttgaa tatgattttt 19680
tttttaaagt tcactaatct agtataagtt gtgacgtaca gacagattct agcgtccttt 19740
aattaaatga cctattctaa aacttcgtaa atgagttcaa gctgtttttt attgggtgga 19800
tggcccttta attagattaa agaattttaa aaaacaaata aaatgttgtt cgtttgttta 19860
ttttttctat tcctatttca aatatattcg attaaatcaa tcgaaagttg attaaataaa 19920
aagttaattg acattgagaa aattaattag ccgctttcta acaaaataaa atttgaattt 19980
cttgaaatga aataaaatgg tgacaaattc atattgattt tcttttacaa tattattatt 20040
aataatttga agatattact atgattttac aaatttgaag atcttattat cttggtacta 20100
ccagagatgc cgatgaaaat attatattac attcatttat taatagagac aacttattgt 20160
gagcacgtaa tttttgttta cacgacaatt actccaaaaa aaatcgaaaa ataaaacaaa 20220
tggttttgtt gtacaatttt tttggaattt acgtggcatt tttggtggtt atttgtagtt 20280
ttgtctgtga ttgtttagtt ttgtcaaata aaaatacaaa aaatatatgt cgcgtgtaag 20340
tttaggatat cgttctacta ttaggaatta atcaactcat aatttggttt aaaaggaaaa 20400
atcacaaaaa aaaaaaacat atgcatcttt tattctagtt gttgtcattg agtggtttta 20460
tttcagttaa atgtttaatg tgtgtgataa ttgttgttta agtattaatt aatatttgta 20520
tagctttatt tttgatttta caaattaggt gggaattttg tttaaattag aaatttaaaa 20580
aaggaaaaga aaggagttta aattgaagaa acccgggttt gggctcaaat ttgagaccaa 20640
ggaccaggcg caattcattt catgacccag tctggttccc tggtctctat ggcctcacca 20700
aacgacgtcg tttaaggcct atcggatctg gaccgttgat caaacatatc taacggtcca 20760
attcaactcc cattttaaaa ccaaacgacg ccgtataaga gtttcaatca aagccgtcca 20820
tcttgttcaa tcctacggtc cccaacacgc ctcattagcc caacctattc ccgtcaaaaa 20880
ctgacccagt cccctatggg accaaacgtc gtcgttcccc ctaaacgaaa gatcctgtcc 20940
atcaaccaca cttcatccga cggtcaggat caaaccaccc accccatata gaaatctaaa 21000
gcctacccca gcccccaaac caagcacccc cccttctctc actgttcctc tgtctctctc 21060
attcagagac ggacctaggt ttaaacccta gccgccttag ttcccttcct tttgaaaccc 21120
ggcggcatca atgccgccgg ccaccatctt aacatcctag gaccactcaa ccaccctgaa 21180
tccgaatcca caaacctttt ggctcgaatc aattcctaga ttctcgaatc ttcatttgga 21240
gattcgaacc aaacctcaac ctacaccaac cgacctcaaa ttcacaccag ttgctcccct 21300
gacctccctc ataccctaat caacggtggt accgctcgaa tctaggtaga acccttcgag 21360
ccccaaatcg gcctgtatga accctagaac tcaagatcct gggggtttgt ccaattaaaa 21420
gaggagttgg ggtctaatag acctcaatcg aggtgttttc agtagagaac atttcgattg 21480
aagtccgttc gacctcaaag aagtcaagtc cagttcgagt ctgggttttc tttgttctta 21540
agcttccaag gtaatttttc ctttccttct gttctgttag tgattctatt tgtatctctt 21600
tatgtgttta gtttagatta tatgattttt tttaaattaa ttctgtctgt cttcataaga 21660
ccttttattt gatccttctg tttgtttgtt aattgtacat gttgtgagtt atgtgtttaa 21720
cctattcaga gtcgtcaaat agttagttca tatagttttc atgttatgtc taaagtcact 21780
gaagcctcat ggtaacctag tttgtctagc ttgtttatcg attgtttgct atctattata 21840
gctcgtatag tcgattatat aaatgtcgtt aactaaaatc atctgaaaaa ctggagaagc 21900
atgagtttgc tcatgtcagt gtaattactt gcgtgtttct cttgtctgtg ctaagacctg 21960
attgatattg cctcattctt tagtttgcat tatcaactct ttgttgatca agtttggttt 22020
tgagttggtc aggattggtt cccaatatga caaattcatg ccatttgatt aacacccctt 22080
atgtgttatg atgtgtttga acctaagttg agaattggat atagctgtag taatctgata 22140
gttcaacctg aaatcagtgt ttagtgtaag tttatataga ctataacctc aaacctctaa 22200
gcttaagggt aatacaataa atcacaggag tttcaagggt attctagggt tttaaaggtt 22260
ctgaattgct taaaggcaag tgagctgaca ataaggtact aaaatattaa ttaaactaat 22320
gaagttaatt gaccaatagt gggattgatg atatgttaaa cacctttagc atctggaaat 22380
cagtaacaac atgggcttga tgataaaaag ttaaaaatgc acatgagaat agtagtggaa 22440
cctgctgtac agtaggatat ccactgcatt tttaaagttc agcagattaa agtagaagaa 22500
aactccatgc ctaaacaatc ctaagtggaa aggacagcct ttagggttta ttttaagcca 22560
tgggcagcct gcctataaga ggggggttct tcttttctag ggaggtcaga caccaagagg 22620
ttaaaaaaca gaacccaaga actgaagaaa aggaaaaaaa ccagaaagag agaccaagag 22680
tttagaacct gaaagagaga ccaagagttt agaaccagaa gagagggaag gggggtttga 22740
accaaaagaa acttgagaac aaagaggaag ctgaaaattc agcttttctt cgcctttctt 22800
ttgttttgaa atcagcatta actgttttgt tctatccgaa acttggactt ctttcttcga 22860
gtgtcaaaaa accagaaagc tgtggttcca ctgtcattgc ggatccacct atttctgctt 22920
ggcctccgct gagtctccgg agtttgtttt ggtttggatt ttgagcacta tttccattgg 22980
ttgtggctga actcttttac tgggatttat cctgcttact ttattgctaa aattgctgtt 23040
tctgctgttt gctgttggtc attgctgctg cgctgatcac tcctcttttc cttcttgtgt 23100
ccaatatcca ggtacacact tgaatttcac gctgatgtaa cagtaacaat gagtatgaaa 23160
tgaaagacgt gaagaatttc aatcatttgg tgctgcaact atagtcttat aagttgttag 23220
cagattgtat gattcttcaa ggttataact caatagaaat acattaggta gtttgtactt 23280
aattgaaact tagtttgttt aatactgtga ttttagttgt ttagctgtct gtatgatatg 23340
gaatgcacag gtggttagta tatcgataat taaatctcat ctctagtcct attttacata 23400
catcaggcag attgcttcta attcggccaa aatgcaacag agttttaagt catttgagct 23460
gactctatca aataggattt cgttaggcag tttatagaac gatgttcaaa tcccattaat 23520
aacatcctct agtagttaat tccattaatc tcattaaaaa gagttagttt atattcaact 23580
tggagaacgt ttagcgtgag tatagcattt tatcaatctt gtatgcattt ttttttaatt 23640
aaattaaaag catgttcgct catggaataa ggcatgaaat aattatccgt ctcacaaata 23700
atcaatctga taattaataa gaggccggag ctggccaagc atgtaattta attaacgtat 23760
attttctttc tttcattttt agagacaaac ataatagaaa atgtagtcac tgtaggtttt 23820
tcctttcaaa aaaaaaaatg agcctagcct cgccaaaaat acaaaaaaat gcaaattgcg 23880
gggccctcaa taattggtcg taataaatat ttagatttct cgggacggac tgtttagtga 23940
atttcactac cttccccaaa aataataact cgtttgactc tttaggcgcg atttaattaa 24000
attatattct taaattcggg tgcgcattta tgcgacccaa atccaaatct cgacagagtc 24060
gaaatgtatt aacaaccacg agcgcattga ttgtgacgtg gttcgaaatg cattttcacg 24120
acgttgcaat tccataaaaa ataataataa taaaagcggt ttaaacttaa taaaagcaca 24180
taagtcataa catgtattta aatcagatat ttagccatta taacaattta agcgatcgtg 24240
ctagaaccac gggattcagg ggtgcctaac accttccctc gggtcaacag aattccttac 24300
ttagaatttc tggttcgcag acttcatttg gaaagtcgaa tattttcctc gatttgggat 24360
tcaagataaa ccggtgactt gggacaccaa aagccaaacc tttcccaagt ggcgactctg 24420
aancacggga ttcaggggtg cctaacacct tccctcgggt caacagaatt ccttacttag 24480
aatttctggt tcgcagactt catttggaaa gtcgaatatt ttcctcgatt tgggattcaa 24540
gataaaccgg tgacttggga caccaaaagc caaatctttc ccaagtggcg actctgaatt 24600
aaataaataa tcccatttcg aatattgtca cttaaattgg aaaaactctc tcgcgcattt 24660
accctccggg acgggcgcgc aaaaaggagg tgtgacacta ataagttaag atattaacca 24720
acgagtaaca tcactttttg aaaaattgta gtgtcataca attatttgag gagaaacggg 24780
aagaaaaatg ttctcatttg ttcaaccgca aaaaggaaaa atagcaattg aattgatctc 24840
aaggaaaacg aagttgatct taacaactta taaatggata acataagtat ttcctcattt 24900
taaaatttgg tttaggactc gagctttgaa tatgaattta cctttattac agaatatttc 24960
accctttaat gtgaacttcg aggcacaaat tcagatttag tcgagtttca atacggacag 25020
tcaatatgtt tgagaaacca aaaaaaatat atatatatat atatatatat ataaagggct 25080
tatagctagt gaacagtata cttccacagt ctattcagag tacgaggatg gaaacattta 25140
attttttgtg tgtaatttga tcaacataaa ttttaaaaat atttaataag aaaattttgc 25200
gtatttgaaa actaaaaatt acatgaaaaa actgtaagcc tacatagtta ataacttaaa 25260
atatttaaaa aatcataata aaatattatt taattcccta atatataata acatctccac 25320
gtaagaggga gtaggatttt tcagtgatgt ggagaggaag aactgttgaa actttggttt 25380
ggtctccaag gaagaactag tcactactca ctactcacta ctcactagtg gaaaaataat 25440
aagtacattt ttctttttga aagcttaatc cctaaggaag gctccattat tatattacaa 25500
ctgtgataaa gcaaatggac aaacaacttt ttgtttttga tgtggacagg gacaactgta 25560
gaaaccttgg tctccaagga attagtggaa taataattca tttttgtttt tgatgtggag 25620
aggaatactt ttgaaagctc actgggcgtt tggacataag aattctaaag ttttaagtga 25680
aaattgtatt tggaaattag agttgtgttt ggatatgaat ataatcttgg gttatttttg 25740
aatttttgtg agtgatctaa gtgaaaattt tgaaaaatag ctttttggag tttttcaaat 25800
tttcgaaaaa tttcaaaatt catcttcaag tgaaaattta aaattttatg aacaaacgtt 25860
gatttcgaaa aaactaagga aaaatttctt atgttcaaac ggactcttaa tctctaagta 25920
aagcaaatgg acaaacaact ttttattttt ataataggat aaaaattaag agaccgtttg 25980
gattggctta ttttaagtac ttttaagcta aaatagcttt taagtcattt tgtagtgtct 26040
gaataaagta aaaaagtgct tttaagcact tgtttttaag ctaaaatgat aaaaaaagtc 26100
aaaagccaaa agctaaaatt cctaacttat gacttttggc ttaaaagtca cttacaacaa 26160
gcccgtccaa acgggatcta aaggacatta tcgaccaata gtactagtat gtgtagctcc 26220
ttagttacat attcatttaa acccataact tttgacatat atatatatat atatatataa 26280
gatttgaacc gggtgcggct caacactatt ggagacctaa aacccaacta gcataagaag 26340
cctttaacct tcccccctcc caaaaaaaat tcttatgtat acaatttttt taaaatctaa 26400
ttttctagct ttttgagatg caaaattatg aataattatt ataatttttt tctaataatt 26460
ctttttcaat cggtaatata actaatccat ttaatctttt ttgcgccatg gttgatttta 26520
agtaagaatt tatcaatttt aattttaaaa aacttctttc aagtttctag tttgtggtcg 26580
agggtggcca gaggcaattg ttatgggaac tagtattatt attctataag caatataagc 26640
atttgaaaaa aaaagtcttt ttatctgatt aagtgtatca actaaagtac tatgatctct 26700
tctttttttg gggattgtat caatgattca tttttttttc tcttaagttt tgaataatcg 26760
gattcatact ttccatttga catatttaaa ttttgacaaa tactaagagg ataatatctg 26820
catgcgtatt gaaatatcaa gaaaaacaaa ttttagatga aaattaatat tgaaaagttg 26880
gaatagaaaa acctgagtta ttaacttaat gtgaaaataa atatttttgc tttgacaata 26940
tacttctcgt aggctttagc ttgatagatg aaaaatgcag aataatagga tctctgggag 27000
acacaaagaa aaatataaca gtaataacgt ttggtgagaa ctgagaaact taaaaaaaaa 27060
ttgaatattg taaaaaccaa gaaagaaagt ggaaagattt acataatatt tatcaaagac 27120
ataataactt gattcctttc ataaatttta catttacatg ttaggggccc aattttaagg 27180
aatatagata tttttccttt tcagttttta ccaagatatg taataagaat aaaaatactt 27240
aatttttaaa aagggtatag gttaaaaagg t 27271
<210> 65
<211> 52281
<212> DNA
<213> Nicotiana tabacum
<220>
<221> misc_feature
<222> (11517)..(11517)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (52150)..(52150)
<223> n is a, c, g, or t
<400> 65
ctctaaaatt aaatttcaaa cccagaattt gaagtaaacg tccagaaact aattcaaccc 60
aaataatgga ccagacagaa cttcagccaa gctgatttta gttcatttct aaggtcagct 120
agtcagaact tgttgcacca ccaggaaaac tgcagaaatt aatagaagac tcaatgaaac 180
agtaaaattt ctagcatttt tgtatttttc tgagcttttc ttctttttac cccttgggtc 240
tgccttgaaa agcaagaaaa gctgccttta taggcaagtt attagggaag ctttcagata 300
ttagtctttg cacatttgaa ccttttaaaa ttttcattat agctcagata cccttattaa 360
aagaacagaa aatcagaacc aaccccttcc ccagcttcct agaagcttcc tagtctgtta 420
tagcaagatt cccttaagtg acttacccaa tttaccacca ttacccctgt attttacctt 480
gaagcccggc cagacttgaa catgggcttt ggatccccaa acaagctcaa tgcttaacta 540
gacatgggct tagactcaga ccaaacagaa cacctttaac atgagatctt agactgtcct 600
aagagcccac agacgaaacc caaacaaatt cagaagacta aaaaaccaaa caaatcaatt 660
aattaacaat cacaaacagg cagcgaatta attaagctta gtgaccaaaa caaagacaaa 720
aatgagaaat ttaagcatgg cactaatgaa agttaaccag gccataaact tcaacaaaag 780
aaagctgaaa aaccaacgga acatatacga acgcaaaatc aatcttaagg gaaactaggt 840
ccagaacctt gttcaaattt caatcaaggt aaaaaaaact taaagaaaag aagaggaaca 900
aaaggtaaac tcggatagaa aagaaaaagg gaaggaaatt taccctagca aacccgaaat 960
ggcatcggac accttgattt aaacggaact gatgctaatc acttattctt tgtcaagaac 1020
aaatgagcag catcaattcg tgttgaatca gacttcaaac tcgagcaaat cggaggctta 1080
aggtcatgca tgcccacaac tttgatggaa ttttagggtt cgaactcaaa tttgaaattc 1140
ggagagttct ggggtgattc aagggaatct aagtgggcat ttagagtgag ggagagatgg 1200
gggttcaagg gtgtgatttt ggggtcgaac cgaggtggcg ccaccaccgg agaacatagg 1260
ggcggttcta aggtttttct ttcaatccaa gattcgagac gttctgggct tgttcgatgt 1320
aaggtgcttg tagatttgga ttgagggagt tgaggagggt gtttggtgtt aatttggggt 1380
cggttcgtgg tggcgccgcc accggaggtg gggggatttg tggcggcggc gcagggtttg 1440
caggggcggg ttgtgaggga gatgagtgag ggttatgggg caggtttgga tatttaaata 1500
ctaagtcgcc ctgtcttcag gactatccaa tcaagaaacc tcgacggtcc tgaactgttg 1560
cccattaaac gacgtcgttt ggtttggggg gaaaccgacc gggtcaaggc gtgggtttgt 1620
gccgggtact gggtaatttc gtttgggctg gggacagtta aatgggtttt agcccaaatc 1680
tggatttctt tctttttctt ctttttttca atttcaaaat tcttttcttt tcaaaattaa 1740
aataaaaact aaattaataa taataatttt taaactaaat taacctaccc aattagatta 1800
atcactcacc atggtattta caatacttaa ttaaatccta aatttaaaga aaactataca 1860
attcaaaatc aaaaagtaaa aatgcaaaaa tgaattattt ttgtgatttt tatttttttt 1920
ataaacaaac taatttacta attaatctaa aaatataaaa ttaaatccta aatgcatatg 1980
caacatattt tttatatttt tcatgaatta aataaaataa acgtgcaccg acgaatgcaa 2040
ataattaaca gaaaatgcca cgaaatccaa caaaattgca aacactgaaa gaattttttt 2100
ttttgaattt gtcggagtaa tacatatagg gcaaaaatca cgtgctcaca attgcccctc 2160
tttgctcgga aatacgaaga gttttcgtgc aaagataagt gaacggatac gagcaatttt 2220
tgcccatttg aatactccat gggaagcatt tttgaaagat ttgaccgcac cctacttcga 2280
ggttgcctac atatccttgg ctaaaaagga atcaggtcag tatagttcag aaatgtctgg 2340
tagctgggac taccatggag ctgtgatttc actgttactg ctgctgctgc tcactgaacc 2400
ccttattaca ccatgtcaaa aataaaataa gctagactag actatgatct atgctttaca 2460
aaatcttgtc ttggtcttca aacttgatct ttttttttct tgttgccttg ttgccttgta 2520
ttctcttggt aaaattcctt tgttgccgtc ttgaattgta aactgagatg cttccctttc 2580
tccaagtgga tgtctgactg ctgaacttga tatgtattcc catgctatcc aggcgggctc 2640
ctggcttcaa aatgtgaatg tattctcatg ctatccatgc gggctcctga ctgctaatct 2700
gaaagtgttc cctgcttttc aggcgggctc ctgactgcta atttgaaagt actccctgct 2760
ctccaggcgg gctcctgact tcaacaaaga attcgacagc taaaatttaa attgtactcc 2820
cttgttctcc aggcgggctc ctgattgcta cgcttgaaag tattctctac tctctaggca 2880
ggctcctgac tgctaaactt gaaagcattc cctgctttct aggcgggctc ctgacttcaa 2940
catttgaaag tattccctac tctctaggcg ggctcctgac ttcaacttga aatatattcc 3000
ctgctttcca ggcgggctcc tgacttcaac acttgaaagt attccctact ctccaggcgg 3060
gctcctgact tcaacttgaa atatattccc tgctttccag gcgggctcct gacttcaact 3120
tgaaatatat tccctgcttt ccaggcggga tcctgacttc aacacttgaa agtattcact 3180
actctccagg cgggatcctg acttcaaaat agacaaaaca aagaaaattt tcctgcccct 3240
gtttggtggc tgggcatagg tatgagtgta aaactaaatc atattaccaa gtattactaa 3300
gaattgaaag ctagatccca ttattcagga ggtcctgaca actcttaact aaacgacaat 3360
atttaaaacc taagttatgt cttctacagg tatgatttct gctaaatctt gtaatctaag 3420
agggtcttaa actactctcc attatccagc agggtcctga aaatcaaaag tcaagtttta 3480
tcttaagagt ggcaactttc atggctgaac tatactaccc tacagcagaa cttacgctaa 3540
atgttattat ctaatcgaaa atttaaagct aagtcccatt attcaggagg gtcctggaaa 3600
ctcctaattg aatcctatct cgaacctgca aacttctaag ctaacttata ttcttttcgg 3660
atacatttat gctagattat gctatttctg aactttaaac taggtatcat tttccaggag 3720
ggtcctgaga gtttacggtc aaaccttttt tgatgcttgc tctttcccct gcggagagtt 3780
tctccgaaac aaatgaattt tctgcccctg tttcaatcaa agagaatttt gtcagtttaa 3840
agtggtggtt agctgatggc tttcttgctg gagatctttc cactacatta ttttgttctg 3900
aatggctttc tcgaactggc cctgaaccgc tttgactttc tgactgactt tcaaatccca 3960
tggcctttaa caaaccgagt gttctataca catgctgctg tttcacaccc ctgaccccat 4020
tatctgaacc tttgtatctc ccatgacatt accaaatctt tccaccggtg aaacttctag 4080
tgatcccctg tatcccgcct tacatcatgc tgtctttact aggctctggt cgcgttgtga 4140
tttgcaattc tggaagttgg tagtgagttt tgaaattctt ttccacttac ttgggacaaa 4200
actgatatta aaacatctta aacaaataaa cccaaaagaa aacgaaatgc aatgacctta 4260
cgggttaagg ataagaagaa tccaaaacca gatgactgct acaaagggaa aaaagaaaaa 4320
gaaacttatc tgagtggaac agctggcacc aatgatcatg acatgcattt cgtattaatt 4380
ggcccaatct gtccaaccga tccactttca gttgtcgtac ttcatcgcct cagcatttcc 4440
atgacttgat tactttaccc aaaccttaac cttgttcatc ctgcggtgcc ttaaaacagt 4500
tttccaccaa cagacctttc tcacttgtca actcactttc gcctcagggt gcccgtgaag 4560
gttttcacca ataagactct ctcattttaa tttctctcaa ctcccattgt cttacggtgc 4620
ctgtgaaggt tttcaccaat aagactcttt tatttttatt tttcctactt gaaccagagt 4680
gctacccctg acatgaatta cttttacccg cttgacttgg catttctcaa agactgatca 4740
gaaggtcttt ctttggactg taatgtgggc ttttggacat ggttagaaag aaaaggtata 4800
aaaagctcaa aataattcaa atgggttcaa attacaactt tcggaatcag atttctcaca 4860
acgatcatga cttttgcccc acttttcctg cttggggact tttggatttt taatttgatg 4920
agaacgaacc gtgaggctgc ctacgtatcc ttaaaaggaa tcaggtcgaa cgtagttcat 4980
gttataggaa ttactttgtt gttgtgattt tctcttttct ccttcttttc tttctctttt 5040
gcttttcttt tttccttttt attgtttttc ttcttctttt ctcttttcct cttcttctct 5100
tctttttttc ttctctcttc tcttttttct tttttttttt ctttcctttc tttctctttt 5160
ccttttcttc cttttcttat ctttcatgct tgtgcttctg atattcacta ctgatttcga 5220
aggaggggta agaaagaaaa taaataaggt tcaaaagagg tgacgaggga taaagtgttt 5280
tagatagcag aacaaaatgc tttcatcatt tcaatcttca aaatatgaca aatacaaaca 5340
agtacaatca acaaagaaat catacatagt atctcttgac tgtatcggaa ttgatagcca 5400
tttccacaca tttcccttcc acatctgtca aatataacgc gccattggac aacactctag 5460
ttacgacaaa tggcccatac cagtttgggg cgaactttcc ttttgcttca acctgatgag 5520
gcaagatacg tctcaacact aactgacata cttcgaactt ctgtggacgt accttcttgt 5580
tatatgccct tgtcattctc tgttggtaca attagccgtg gcatactgct gtcaatctct 5640
tttcatcaat cagacttaat tgctccaagc gggttttgac ccattcaacg tcatcaattt 5700
ctgcctcagc gacaatccga agggatagga tttcaatttc tgcgggtatt actgcctccg 5760
tgccatacac caacaaataa ggagtggccc ctactgaagt acggatggta gtgcgataac 5820
ccagcaatgc aaatgatagc ttttcatgcc actgtctaga accttccacc atatttcgaa 5880
gtatcttctt tatattcttg ttggctgact cgactgctcc attcgcctta gggcgatata 5940
gggtggaatt gcgatgtatg atcttaaaca gctgacatgt ctctgtcatc agatgactat 6000
tgagattagc gccattgtcc atgatgatta ccttcggaat cccaaaccga cagatgatat 6060
ttgaatgcac aaaatcgacc actgctttct tagtcacaga tttgaaagtt ttcgcttcaa 6120
cccacttggt gaaataatca atggctacca gaataaacct gtgtccgttt gatgctgctg 6180
gctcgattgg cccaatgaca tccatgcccc aagcaacaaa gggacatggt gccgacattg 6240
tatgcaattc agatggtggg gaatgaatca aatctctatg cacctggcac tgatgacact 6300
tgcgcacaaa attgatgcaa tctcgcttca tagtgagcca gtaataacct gctcggagaa 6360
tcttctttgc cagaacgtac ccactcatat gtggtccaca aactccggag tgtaactcaa 6420
tcatgataat tgtggccttt ctagcatcta tgcatctgag caatcccaga tctggagttc 6480
ttttatacaa tacccctcca ttgaagaaaa atccacttgc caatcgtcga attgttcttt 6540
tctgatcacc tgtggcatgt accggatata cctctgttct gatgtactct ttgatattat 6600
ggaaccatgg ctccccatca agttcttctt ccaccatatt acagtaagca tgctgatcac 6660
ggacctgaat cagcaaaggg tctatataag ccttatctgg atgatgtaac attgacgcca 6720
gagtagccaa agcatcggcg acttcattat gtattcttgg gatatgcctg aactctattg 6780
actgaaaccg ttgacaaaga tcatgcaaac attgtctgta cggtatgagt ttcaaatccc 6840
gtgtttccca ttctccctga atttggttca ccaagaggtc cgagtcaccc aaaaccaaga 6900
cttcctggac actcatatcc acagctaacc tcaaacccag aatgcatgcc tcgtactcag 6960
ccatattgtt gttgcaataa aaacgaagct gagccgtaac agggtagtgt tgccctgttt 7020
cagaaataag cactgctcct atccccacgc ccttcatgtt tgcatcccca tcaaagaaaa 7080
gtttccatcc cggcttctca acttgctcgg actcatcaat gtacatcacc tcttcatcgg 7140
ggaaataagt ttttaaaggt tcataatctt tgtcaaccgg gtcctcggcc aaatggtccg 7200
ccaaggccgg tgctttcatt gtggttcgag tcacgtagac aatgtcaaac tctatgagca 7260
agatctgcca ctttgcaagc ctccctgtgg gcataggctt ttgaaagata tacttcaatg 7320
gatccaagcg agatatgagg taagtagtat aagaggacaa ataatgtttc aacttctggg 7380
ctacccaagt tagggcgcaa cacgtcctct caagatgagt atacttaacc tcgtacggca 7440
tgaatttctt gctaaggtaa tagatggcct gctccttcct accagtgata tcgtgttgac 7500
ccaatacaca accgaatgaa ttgtccaaaa ccgtcaaatt tagaatcaaa ggtcgccttg 7560
gttctagcgg gaccaacacg ggtagatttg acaaataccc ctttatctta tcaaacgcct 7620
cttgacattc atctgtccat ttgaccgtag cgtctttatt taacagtctg aagataggct 7680
cgcaagttgt cgtgagctga gcgacgaacc tgttgatata attcaatctc cccaacaaac 7740
tcatcacctc ggtcttgttc ctcggaggtg gcaattcctg gatggccttg actttcgatg 7800
gatccagttc aatgccccgg cggctgacta cgaaccccaa caactttcta gacggcaccc 7860
caaaagcaca ctttgcagga ttaagcttga gattgttcct gcgaagcctt cgaaagaact 7920
ttttcagatc actgacatgg tcagactgct ttctaaactt cacgatcaca tcatccacgt 7980
acacctcgat ttactagtgt atcatatcat ggaatattgt tgtcattgcc ctcatgcagg 8040
ttgccccagc attcttcaag ccaaatggca tgacccgata gcagtacgtt ccccacaatg 8100
tgatgaatgc cggcttttct gtatcttcca cgtccattaa gatctgatga taagtcgtgt 8160
aacaatccac aaaagaacca atctcatgtt tggcacaatt atcgatcaag atatggatgg 8220
tcggcaatgg gaaattgtct tttggactcg ccttgttgag atcccgatag tcaacacaca 8280
ccctggtctt gccatccttc ttcactacag gcacaacatt ggctaactaa gtgggatgtc 8340
gggtgaccca aatgactttg gcatcgaact gcttggtgac ctcttcctta atctttacac 8400
tcatatctat tttgaacttt ctcaacttct gtttgacagg agggaattcc gggtcagtgg 8460
gcaacttgtg aaccactaaa tcagtgctta gacccgacat gtcgtcatag gaccatgcaa 8520
aaacatcttt gtattcgaac aataatttaa ttatttcctc cctgagttga ggttccatat 8580
gtacagttat cttagtttca cggacatttt cttggtcccc tagattaact gcttttttat 8640
cgttcaaatt aggtttgggc ttttctcaaa atgacttagt tccttactaa tttcttcata 8700
ggcctcatca tcatcaaatt ccaactcgtc atcacactca atttcttgta ttattatttc 8760
agagttagat tggcttttaa aattgggccg aagattcctc atgcatgtca tgtcattgat 8820
atcagcataa aaagaactgt acaaaagaac aaaacaaaaa taaaattaga agaaatgaag 8880
gaaaaggaac aattgcattt cattgaattt aaagataaga gggttttagc acatccaact 8940
ggagggaaca taatatctga attacagacc ctggaataat ccagacaaca aaagaaaatc 9000
aaaacccact accaagactc catccggata ggaagaggag tagcttccca gttgttgact 9060
tttgcacgtg gtcccacgaa ttgcacatct gccttgcctt tcccagcctc aaccatgtta 9120
acctcagcga ataacctttc gaaccccttc tccaagtctc cgttggcacc aatcagtgat 9180
ccaggaacct ttgacaacag ttgctttctg ctacccgacc tgatgaatga tctggacaga 9240
cgcgggattg gctttggcaa tgcccatgct ttctgtttca ttttcctggc tcttctcaca 9300
tccacaactg tgggcttgaa ccctaggcca aaagtatcta gattccttgg aagagaaact 9360
ggctacacaa taccttgcaa agatgcaccc aaacccttgc ccggtacgaa accatttttc 9420
aacggctacc atgactgatg cagtagctac ctttggagtt ggaatgcact tcccttctgg 9480
aattttctca tcctatactg tgtcaaaaac ctgataaacc catggcccct tgtcgtcttc 9540
aacctctatg agtggaacaa tggcatcatt gggcacacac aaattatcct tgtcgtgtat 9600
gacaatttcc tatcgatccc attcaaactt gacaatttga tgcagagtag atgggaccgc 9660
cttggcagca tgaatccaag gtcgtcccaa cagcagatta tacgaaacag ccacatctag 9720
cacctggaat tccatagtaa attcaactgg ccctattgtg agctcaagca ctatgtcccc 9780
gactgaatct ttccctccac cgtcgaatcc ccgaacgcaa atattgttct tgtgaattct 9840
ttcatcctcc acttacagct tgttcaatgt ggagagagga caaatgttcg cgctagaccc 9900
attgtcaacc agtacccgag taaccacgga atcttcgcat ttcaccgtca gataaagggc 9960
tctattgtgc tcggtaccct ccacgggcaa ctcatcatca gaaaaagtga ctctgtttac 10020
ctcaaatatc ttgttagcta tcttttccaa gtggtttact gagattttgt caggaacgtg 10080
gtattcgttc aagatcttca tcaaagcacg acaatgctcg tctgaatgga tcaataatga 10140
caagagcgag atctgagccg gtgtcttcct taactgttcc acaatggaat agtcttgcac 10200
tttcatcttt ctcagaaatt cttctgcctc ttccttagtc accgctttct tcaccaacac 10260
tggattattt tttgaggtct tagcttttct cagctcgtcg ggggcaaagc atctccccga 10320
tcgagtcaaa ctatgagtct cacatacttc ttctttaacc tctttccctt tgtaagtcac 10380
ggtcactcgt tcataattcc atgggactgc cttgctgttg actatcggta attgagttac 10440
cagtttgata acgacaggat ctgtgggggc gcccttcaca atgaccacaa gattgttcgt 10500
cactcctggc acaaccactt tttctctttc atgttttcct acgacgtcac tagtggaccc 10560
cttcttgacc tccacagatg gttcattatt tgcgctgttc aacttgatca tagacttctc 10620
acttgttgac ttttcaaatg gtctggcttc actagcccga atcatcatga cggtttgcga 10680
aggcttctta ggctcccctc ccttatgcac tatctcgatc atatttgttt catgatgggc 10740
tggcaaggga ttctggttga tattaggtgc ctccgaagct tggacctcaa tccgattggt 10800
gtcaatgagc tcttgaatag ctgttttcag tttctagcat ttctctgtat catgtcttag 10860
ggcccctgag caatactcac aactcatcga gcggtcaaga tttctgggag ggggatttgg 10920
caatttagcc tcgatcggat tcaacatacc caactgtctt agtctgtgga ataagttagc 10980
gtacgattct cccaatggag tgaaagtctt ttgcttctac aacctctcat tcttaaaggc 11040
ttggttgggt cgaaaacccg ttccaggagg atttctgtgg gcttttgggg gtaggtagtt 11100
attttgtgga gcttggtatg ggttttgtgg agccggcgca tggtattgtg catgagtggg 11160
aggttgggta taggtttatg catgatggac agaaaaatag ggatctggcg gtgggtaata 11220
gtgttgtggt gggttatatg gagtttgggg gtaagtttgg ggatagggtc gcggctggtt 11280
gtagtaacgg ggaaggttcc tggatccaac ccaagctctc gactcaattg tcgcaacatc 11340
ctccttcttc ttcttcccga gcacaccccc agtaccgttt tgaatggcct gagtggtcgc 11400
cttgattgct gaataactca tgatcttgtt ggacttgagt ccctcttcaa ccatgcctcc 11460
catttttacg acttcattaa aggacttacc tactgttgac accaagtgac cgaaatntaa 11520
cttacctact gctgacacca agtgactaaa ataagtgggt tccaaatcct gcaagaaata 11580
atcaaccatc ttgctttctt tcatcggagg gtcaaccctc gctgcttgct ctctccaacg 11640
gaatccatat tccctgaagc tctcaccggg catcttctca agctttgtca acgatagacg 11700
ttctgggata atttcggggt tgtactgaaa atggcaggcg aaggcttggg ccaaatcatc 11760
ccatgtgtac cacctgttgt gatcttgtct ggtataccat tctaaagttg atccacttaa 11820
actttggttg aaatatgcca tcagcaattc atctcttcca cctgctcctc taatcttgct 11880
acagaatcct cttaagtgtg ctaccgggtc accatgccca tcgtacagat caaacttggg 11940
cattttgaac cccgctggca actgaacatc tgggaacaga cataaatcct tataagccac 12000
acttatttga catcccaacc ccctcatatc tcagaatgac tgttctaagc ttttgacatt 12060
tctgatcatc tcttcatgct cgggagtttt gggcggtttc ttggtctttg tcgggatatc 12120
aagatgaggg gtgtaaggat atggttctgg aactttgaag gtgggtttag agggatagta 12180
ctggttttcg tgagtttaga acaggggttc actggaaaat cgatgtaata tggcaggtgg 12240
aggtgccaca aaaacagggg taattggtgg gggagggtat gagacttgtt tgggtggtgg 12300
agtttgagaa gtatgggaag tggtgccata gcattgttgg tagaggggaa aggctggaga 12360
tgagttcaca gtgggaggat ccggaggttg ggctgatggt gggatataag cagggttggc 12420
aggataaacc ggtggtggat gccccttcgc ccaagcttgg tacatttaag ccatctgttg 12480
cttcagctta tacatttctt ccctcatcgc attaacgtcc atttcttcca cctctttcga 12540
tgggtcgata atacttgttt ctggttcctg gttggccata tcagcctgtc tttcgatcgg 12600
gtattgtatg agtgagttgc caaaatgtcg atcaactaac cacctgcctg agctcaatac 12660
atcaacaaca acattgttag cgattaggct ttaacagatt ggtaaccgca cattgggcat 12720
gaatgcacct aaatagttaa ccgactctat tatgtatttg attggttgca tgcgtcatcc 12780
cggccttttc tttcttccga ttgcaaactt ccctcttttt ttcgtttcct tccgttcact 12840
cttgcctctg ttctctcttt gtttttactc tctcttgatt tcttattttc tctctctttt 12900
ttgtttttcc gctcttttct tttctttact ctcttgtatt ccctcttatt ttctttcttt 12960
ctcttgtttt tccgctcttt ctttctctct tttatttggt tacggtcgaa tcgtatggag 13020
attgcctacg tatcatgacc ccgcatgaat cagaccaagc gtagttcttg gggataagtg 13080
tgaaataaag taaaaacatt ttgggatttt cagtttttca tatataaaaa attgctatta 13140
caaaggctaa aattaacaga cgggaaagaa actaacagac tctgatgaaa gaacgagata 13200
cagactcaaa aacaaacaac ccacacattc tgataacaga aatatcgact ccacaaaaac 13260
tggcagactt taacggaaag aaagtacaga ctcaagaaat cacgaataca tcaatgcctc 13320
aattgtcctc gggacctgcg gggcatcatt cggccttgtt gcgggccgac tcgctaaatc 13380
cccctgaagg tggtagagat cttccattac ccggcgaaca aaaatcatca cagtagcaaa 13440
gaacatagat cgagtcatat cctcacagct actgcacttc atcgcgatat agttggcaac 13500
cattttgact cgctctctta tgacgccctt ctctcgcaac aaacgcccaa tttgtttagt 13560
tctggcttcc aaagttcgtt cggccacctg gttctgctct tggagttgtt gcaagtccct 13620
ttctagtcgt accattaagg cgtaacaatg ttctctttca gccttaaaat ttttggcttg 13680
tttggccatt tcaccctcga ggttgccaat tgccttttcc caacccgtga cccctctttc 13740
atatctttct ttcatctgtt gaacgaaagt tgcacgccct tcagcacttt tagccaacct 13800
tgcccgtgct tttgctagtt cggactcagc tttctgcatg tcatcttcat agtcacgtac 13860
cttttgagtg aggttgtaaa tgagcctctc atctttccta cttcggcctg ggttctcggc 13920
ttccattttc aactgtcgaa cctgagctct aagggcttca ttttctcgca ccaatcttct 13980
cctttcacct tcggcctctt gtgcctgcaa atcattgttg aaggtgacat ttctcagttc 14040
ttctcgtaaa caatggatga tggccttata ttccttttcc ttctccccca agctaacctc 14100
tcttgaactt tatcatcaaa ggcttgaaca tgaggccttt tgggctctgg ctcgttgttt 14160
acataataca ttttatcaaa ccaagcagca taatttggat ctacttcccc cttggcgatg 14220
tctggtacct gggtgccatt ttttagatac cgacagctat tccaatccta ctaaactgca 14280
gcctcgggca atgcagcttc tggatgtaac tctatgacct gggtgtttag atcttcatct 14340
ttaggcacaa tctgatacct tcccaattgc cttaagaccc tctgcggtgc atatggctga 14400
atactcctta ctcccattat cctcaggtat cctttggtag cagtcatata gatggcctct 14460
atcttcggaa gcaatcctat agtccactca acctgacctg cgtcaagaac tttcaaatga 14520
gaaactcatg cttcaaatcc ttctggtgtg ttgtaatatt ttatcctctc ctcataacta 14580
atgatgaagt tgtttgggct cgaaccgtaa ctcatgaatc tgggatgatg gcgaatatgc 14640
tcgatcaacc acatttgcag aatgatgctt caaccttcaa aaaattgagc ccctactttg 14700
cataaagtca atgctcgata gatatctgcc accaccaacg ggacaagtgt atgatcttcc 14760
ttggtagtga ggatttgtgc aattctagcc atacgaatat ccatcgttcc tttctcattt 14820
ggaaaaatca tgatccccaa gaatgccaca ataaatgcga accggagatg aacttgccaa 14880
agacccttgt tttgtttatt gcttagacca ttttcatgca tttcaaaacc ggcagaatgc 14940
ccgaacctga agtataagaa atggaaagca caacacccat tgctcacacg ttccttattt 15000
gtctgtttac taatattcag gatgtcaaag aacttgtgca cagatggagc ccttggaaat 15060
ataagttgtt gtttcctcaa atcccgtctg aattcaatgt acccggctat ctcctccaaa 15120
gtaggggtga tctcaaaatc cgaaaaacga aagacattgt ggacaggatc ccagaaagtt 15180
accaaagctt tgatcagatc ttcccgcggt ttgattccaa agaagtctat aagagcaccc 15240
aagtgctttt tcactcattt ctgaccatct tcgtctagat cattctacta catacgcaag 15300
tgtagccgag actgttccct aaccacttct ggcggttcct ggatggtatt catttgttct 15360
tgcggaagat taaggttaag gttgactcga gttgaccctt ttgtaaacag tttttgaaga 15420
agaaaggaaa aataaaaaag aaaagaagaa aataaccata atttcttccc ctatatgcca 15480
actttagcca aatggctgtt tttgcaaatg cggccccttt ccaatttcgc gcgaattttg 15540
aggccggggg gaattatttt tatgacccct cacaaactgg tccattcttt cacggaaata 15600
gcctttcgac aactgaagca atattctgag gctatcttgg caagaacggt ttacaacatt 15660
actgaagctg aatcggctta ttttgaccga aaatcaagat tgcgttcact cgaccaccga 15720
ctctctttcc ttgttttttt tttttttttt tcaaaaataa ggccgaacct tatgtaggtt 15780
gcctacgtat cccacatccg gtgagaatca gacctgcgta gttcggtcag ttttgacaca 15840
tttgaaagaa catcatgttt gactcttttg gaataactct ttttttgaaa aaattttggg 15900
cagagtttca ggacgctttt caaataccga gatgtttaga accgggtttt acttccttcc 15960
ctatatcact tttggttttc ctctcttttt tcgctttatt ttcccatgtc ggtcagcata 16020
caagctaaaa taaatgttca catagcacgt agaatgcatc aggatggtct gttatttcgg 16080
gcatacctgt cctagacgga cccaatccct gtgttgagtc ccctaagtca aatgcatatg 16140
atgcaaacaa acgctcctac tagggattcg gcatgaggct gtgtttttct aggtttaaat 16200
cctggggttt tggtctagac ttggggtacc cgagcagata attggagccg aggagggggc 16260
gacgtaccgg gatcattgaa gtctacctgg ccttgtcgtt ggcccagcct cgttctattt 16320
ggtataattt ctatagaaaa agtgggctac gcgaacgtat gcaccatttc cagaagacta 16380
agatgggtgg cgtaagaaga cagttatata caattcagat aatattaaag cggtaaacag 16440
atagcattta gcacaaaaga ttcacagaat acagtaatat caacaataaa taaagccaag 16500
taaaaaatat gttaacaagc tcgaattctt gaaccctgaa ccagaaattc tgggttcgat 16560
ccccagcaga gtcgccagag ctgtcacacc tcctttttac tacaccccgt aaaatgtata 16620
aattcaaggg agtttttcca attaaaggac aatcgaaaca tgattgttta tttattaaaa 16680
atcagagttg tcacttggga taatttaggg tgtcccaagt caccggttta aaatcccgaa 16740
tcgaggaagt tgactcttat ttatggttcg cgaacacaga aatccgggta aggaattcta 16800
ttaacccggg agaaggtgtt aagcattctc gagttctgtg gttccagcac ggtcgctttg 16860
atcatacttg gcttattaaa attatttaat tattgatttt agatcctatg tgcatttacc 16920
ctttaccgct tttaaatcac ttgattattc gtagttaaag aattgagtta cgcgtacgta 16980
tactcttttc ctttggcgcg tcaaaaatca tgtcacgcga acgtgtccat aattaataac 17040
gctttgtatt attaagaaag tttagccgaa gttacgcaaa cgtatacgaa catttgttaa 17100
agaaatcgta atcgtgtcac gcgaacgtgt ccacaatcat gatggtattt taaacggccc 17160
taaaggtttc tctacaaaca tttgttattt tacatctaca ttatgaaatt aacacaagag 17220
ccatttgtta ctaagtgtct aattatggct tgcctccaat ttccttttca agaccctaat 17280
tatttaacac taaagtactt gacaaatccc ttccaatcaa caaggcttca ttgaaccatt 17340
ttattagcgg aagggcctga attaaacagg cccaaacttc tgagaaacaa acctgcctca 17400
acgtagggga aatcttttgg atttaagaga ctccaataat attcaggccc aaaggcccaa 17460
atattttggc agcgctggct acaagcaagg acttcaggat cgaatccctg aagccaaaat 17520
ccaacaatga ccttgctcat acccttttcg accattgagg aggggagaaa acgagttggg 17580
ggcattgata agaaccttat acagcaatca ctaataatcc cgtttaaact gaggcgtaaa 17640
ctgtacggaa acatcaattg gctacaatta aaatcaagca aactatacat acatagctta 17700
acacatgaat tatatcaaga acacaaaggt ataaacaaca gaagctaata gaatctaaca 17760
tctaaacaag atttctattc gaattccaat ttgaacatcc gaatctgcat acaaattcag 17820
tctggctcca acttgtggca cttcatttgt tagcaaaggg gataagaaaa tacctgagag 17880
aacaaataag aaagagcaag ggtcagcagc aaaacacaat caacagaacc aaccagctgc 17940
tctaaaatta aatttcaaac ccagaatttg aagtaaacgt ccaaaaacta attcatccca 18000
aataatggac caggcagaac tttagccaag ctgattttag ttcatttcta atgtcagcta 18060
gtcagaactt attgcaccac caggaaaact acagaaatta acagaagact caatgaaaca 18120
gtaaaatttc tagcattttt gtatttttct gagcttttct tctttttagc ccttgggtct 18180
gccttgaaaa gcaagaaaat ctgcctttat aggcaagtta ttagggcagc tttcagatat 18240
tagtctttgc acatttgacc ctttttaaat tttcattata gctcagatac ccttattaaa 18300
agaacagaaa atcagaacta acctcttccc cagcttccta gaagcttcct agtctgttat 18360
agcaagattc ccttaagtga cttacccaat ttacccctat tacccctgta ttttaccttg 18420
aagcccggcc agacttgaac atgggctttg gatccagaac gggctcaatg tttaactaga 18480
catgggctca gactcagacc aaacagaaca cctttaacat gagatcttag actgacctaa 18540
gagcccatag acgaaaccca aacaaattca gaagactaaa aaaaacaaat caattaatta 18600
acaatcacaa acaggcgagg aactaattaa gctaactaat taagcttagt gaccaaaaca 18660
aagacaaaaa tgagaaattt aagcatggca ctaatgaaag ttaaccagac cataaacttc 18720
aacaaaagaa aggtgaaaag ccaacagaac atatacgaac gcaaaatcaa tcttaaggga 18780
aactaggtcc agaaccttgt tcaaatttca atcaaggtaa aaaaacttaa agaaaaggag 18840
aagaaaagaa gaggaacaga aggtaaactc ggatagaaaa gaaaaaggga aggaaactta 18900
ccctagcaaa cccgaaatgg cgtcggacac cttgatttaa acagaactga tgctaatcac 18960
ttgttctttg tcaagaacaa atgagcagca tcaattcgtg ttgaatcaga cttcaaactc 19020
gagcaaatcg ggggcttaag gtcatgcatg cccacaactt tgacagaatt ttagggttcg 19080
aactcagatt tgaaattcgg agagttctgg agtgattcga gggaatctaa gtggggattt 19140
agagtgaggg agagacgggg gttcaagggt gtgattttgg ggtcgaacca aggtggcgcc 19200
gccaccggag aacatagggg cggcgctagg gtttttcttt caatccaaga ttcgagacgt 19260
tctgggcttg ctcgatgtaa ggtgcttgta gatttggact gagggagttg aggagggtgt 19320
ttggtgttaa tttgaggtcg gttcgtggtg acgccgccac tagaggtggg gggatttggg 19380
gcggcggcgt tagggtttgc aggggcgggt tgtgagagag atgagtgagg ggtagggggc 19440
aggtttggac atttaaatac taagtcgccc gggcttcacg accgtccgat caagaaacct 19500
cgacggtcct gatatgttgc ccatgaaacg acgtcgtttg gtttgggggg aaaaccgacc 19560
gggtcaaggc gtaggtttag gccgggtact gggtaatttc gtttgggctg gggacaatta 19620
aatgggtttt agcccatatc tggatttctt tctttttctt cttttttttc aatttcaaaa 19680
ttcttttctt ttcaaaatta aaataaaacc taaattaata ataataattt ttaaactaaa 19740
ttaacctacc caattagatt aatcactcat catggtattt acaatattta attaaatcct 19800
aaatttaaag aaaattacaa aattaaaaag taaaaatgca aaaatgaaat attttttgtg 19860
attttcattt tttataaaca aactaattta ctaattaatc tacaaatata aaattaaatc 19920
ataaatgcag atgcaacata tttgtttgta tttttcatga attaaataaa ataaacgtgc 19980
acagacgaat gcaaataatt aacagaaaat gccacgaaat ccaacaaaat tgcaaaaaat 20040
gaaagaaatt attttgtttt gaatttgttg gagtaataca tatagggaaa aaatcacgtg 20100
tcggagtaat aataatagaa taatagaaat attgaacata attaaacact caactaaaaa 20160
taataatcac aacctcaaga ataaaccagc gtcgcccaga attaccaatc tttaacagtt 20220
caaatataaa taccggaaaa ccaacacagc tcaagaaatg gaaacatata ggttgttgcg 20280
gtgtgcaacc cgatcccact agataacaca taatcctccc ttatttcgcc gtaacaatat 20340
caacaacagt aaataatata tatatgttgt ggcgcacaac ccgatcccac catatgtcaa 20400
tatcaatatc ataattcacc cttacttcac catatcaata cacctattac ggtgtgcaac 20460
ccgatcctac cttacaatac aaattcacct gtattttgcc atatcaatcc acccttatta 20520
tacctgctgc agcgtatagc ccgatcccac catatcagta ctaaatgctc aaagcacagt 20580
caaatcaatg gttcaaacta caaaggcttt acaatcagta aatgccaaac tgaaccaaaa 20640
ggaaaacttg cacattatag aatctacaca agtaatacta cacagctaga ccaatccagc 20700
aatttacaat tagaaggtgc aaacaagtca atttaagcaa acaataggga ttcgtgaaac 20760
tatgaaaaga actaacatta ttaacagtag aaggtattga ttaacatgta gcagttaagc 20820
atgtaaaaca tttagaccat ataacagtta agataggaaa ggaaacaatt aaggaaaaaa 20880
ggtaaatcgg gggaaaatag ataattcagc ggcgtataag cactcgtcac ctcgcatata 20940
cgccgatcgc atgagaatca cataacatat agtctgaggg ttcttaattc cctcaagtca 21000
ctgttaaaca taacacttac atcacttcgc ggccaattca aagctctacc ggggcctttc 21060
ccctagaatc tgcctccaaa ccactcgtat ctagccacaa ctaactcaat aacatcaaat 21120
attgctaaag gaattaatta caatgcataa aattagattt cccaaacttt tccttaaaaa 21180
gtcaaaaatc gactcaggca cgcttggtca aaacccgatg tttggaccaa aatccattta 21240
cccattcacc cccaagccta attatgtaat ttgtctcgaa atccgacctc aattcgaggt 21300
ctaaaatcta tttttttaca aaaatccata attctaccta aacccccaat ttctaccatg 21360
aaaatcatag attttaggtt gaaaactcat ggaaattaat ggctaattga aagaaagtag 21420
gttagaatca cttatcaaca aaattgggga agaaaatatc ttggaaaaat cacctctagg 21480
tcttctagtt ttgaaatttt gaaataatgg ccaaacatcc cataatggga ctgtttaata 21540
actgggcgac attgttcatc gcgttcaagt gaatactgtc gtgtttgcga agagtagggc 21600
ctaagtggcc tacgcgatcg ctagtagttg tacgtgttcg cgaaggtcta tccccccatg 21660
acctccgcgt tcgcgagact gggctcgcgt tcgcgtagag ttacctcaac tccactaccc 21720
agcctagcta aatctacacg ttcgcgtgag atgggtcgtg ttcgcgttcg cgtagagcaa 21780
ccccccaacg ctccacgttc gcgaccatgg tctcgcgtta gcgtagtgaa aaatcctcct 21840
ctaacccaga tccctttcgc gatcgcgaga atgacttcgt ggtcgcgaag cacaacacac 21900
cagaatacca gctgcaacaa acacaccaga ttttctaagt tcaaaacacc tggtagccta 21960
tccgaaactc acccgagccc tcagggctct aaaccaaaca tgcacgtaag tcctaaaata 22020
tcatacgaac ttacttgcac gatcaaatta ccaaaataac acctaaaact acgaattgaa 22080
caccaaatca aatgaaattt tcaataaagc tttaaaacaa ccggacgttc gaatcacgtc 22140
aactaactcc atttctcacc aaatttcatg gacaagtcat aaatattata atggacctgt 22200
actgggatcc gaaaccaaaa tacgaacccg ttatcagcaa gaccaaacgt caattagttc 22260
ttaaaaccat taaactttca aactttcaat tttctacaaa aattcatatc tcgaattagg 22320
gacatcgaaa ttcgattccg ggcatacgcc caggtcctaa attacgatac ggactcaccg 22380
ggactgtcaa aatacagatc cggatctgtt tgatccaaac attgaccgaa gtcaactcaa 22440
tttaattttt aaggtaaaaa ttcttatttt tatcaatttt taacatataa gccttccgaa 22500
aaatactcgt accgtgcatg caaattgaga aaggctaaaa taagatactt aaggattcag 22560
aacatgaaat ttagttttaa aatatgagat gacctatcgg atcatcacat tcatgctcct 22620
tgtagtaatt tagatgttaa tgttatgtcg tcagcaaaaa taaggtgaga tattatggga 22680
ccttgtctgg atagttttat agggtgtcaa ttcctataat ccacttctac gtatatttta 22740
cgggggatca tctccatgca tatgatgaat atataaggtg ggagggggtc tctttgacgg 22800
atgcctcttg agggagtgaa gaaataagtg ggtgctccat tgattaggat tgagatagag 22860
gattgtatca tgtgttttgg aaaattaaag tagtggagag tgtcatgtat aaagccccat 22920
tccaatttat caaaagcttt atctatgtct agttttagga gaaaagatga ttgaccaccc 22980
ttctttcctt aaatggtgca tgatctcttg cacgatgatt gcattatcag atgctttacg 23040
attttttaga aaaacggatt gttcagggct tatgaggctt aatagtaagg gtttaatatg 23100
attgattata attttggtga ttagtttgta aaaggtgtta caaaggctta tgggacgata 23160
ctgagtaata gaggtaggat gttgtacttt aggggtaagg cataggtacg ttttgttcac 23220
ctctggtggc atttgttggg tactaaagac ctccatgcaa aaggaagtta ctgatgaacc 23280
cactttgttc caataatttt ggtagaaata tgggtatagt ccatctggcc catgagcctt 23340
taggggttgg aaggatttga tggcattggt tatttccagt gtagtgatgg gggaagtcaa 23400
attgccagat tcccgattat tgatagtatt gtaagtggct atgtaattag gatacgtgta 23460
gtgggtatgg atagtagtaa ataagttgtg ataattcaat tgagagattt atttcttgtt 23520
agtttgttca tagtaaaaca tgtttgaatt tttataaaaa taaataattt aaagttatac 23580
taatatggta agaaatttat aaacaatctc actaaaaggt agtagtaatt tagtaagcag 23640
taatatgcac taattagtaa ctagttaact gaaacatata ctgtaataat atgtttagaa 23700
taatgctgac cactgggtga cataatttta taacacgata attagtgact attcaagttc 23760
ataccggaca agttttgaca cgcacgaaaa acataacgat ttaagcatta tcttgaaaat 23820
ggattaatag cctgtttggc gtgcttctag aattagctta ttttaaaaaa tatttttggt 23880
gagtgataat ttgtgtttgg ctaatcaatt tgaaaaatat ttttgagcac caattagtgt 23940
ttagccatgc ctttaaaaat acttttaagt gtattttttt ccaaagtact tttcaaaaaa 24000
gtatttttgt ggagaaacta acttttttac ttttcaaaag tcacttttat ttctactcaa 24060
gcatttttcc ttctaaaaac atggccaaac atctaaattt tgccaaatat tttttttgag 24120
gaaaaaaata ctttcaaaaa agcttagcca aacaggctat aggtgaaata gagttatacc 24180
aataatgtaa aaaaaattat attatggtaa ctctctttat atactttata cttaaataat 24240
aataaaaaaa gataaaaaac aaaataaaaa aggtgaggag tttagttgga agtgacatgt 24300
cacatgcgtt tgatacatca ttgaacggtg tcaccatttt ttcttttttc aaaaggtgca 24360
cctgaaaacc cacttctcca agtaagcccc ccccaaaaaa aaacattcac ttctcccagt 24420
caactgaaag tcaatcaccc tttttttctg ccgccggtaa gacactaccg gtgcttccgc 24480
caccgccact gccgccgtaa tggaaggcgg cgactttgag aacggcactg agagtccacc 24540
aagtgctgca acttcaccga tcactgagca gctttctgct ctgtctctca atggcgacat 24600
agattctcct gtttcagttc agaaaccaga gaaagacccc agaaaaattg ctagaaagta 24660
agttctttgc ccttgtgggt gcaaaattgc taaatgtata ttttgaagat tatttgtgta 24720
catatatttt tgttgtgtca tgggttgtga gattttatag aatcatacac tattaactaa 24780
aaccttgtgg tgattttaag tggtttgact aacttaaaaa tctagagaaa taggctgcct 24840
tacagttcgt ttttgcaaga ggttgtttca gtagtttgaa cccgcgacct tcgagtgaca 24900
tggcggcata gatgaatata taattttata gattatttgt ctatataaat aattatttgt 24960
gggtacatat atagttgagc tcattcgcag tttatgagaa atttatagaa atatatatta 25020
attaaaggtt tttcaagtgt aatatcgttc aaaggcgagg tggatgatgt tgaatacttt 25080
gaccaactca aaaagcgtaa gcttgttaaa taagagacac attaatttcc tcaatgcggg 25140
cttgagtcct tatccttcgg tggattgaac acacgtaaat tgtttttgat agcaagtgac 25200
aatgagattt aaagcatttg tcacgtgcag agttgtgtag cttccgagaa gcgaatgaag 25260
ggaagttttc cagcaagctt acgcttactc tcggcctctt tgatcggtag gcaagcaggc 25320
taagccactt ttttttttgt tgttttggaa tcaaacacgt gaaaattctt gtttataagg 25380
gtgtattgac ttgaattcta tgttgctcga actttccata atattgtcgc acccgtgtcg 25440
gatcctccaa aaattcaaca cgcatccgac aatatttgtg aagagtccga gcaacacagg 25500
tgggagcctt ggtgtagccg gtaaagttgc tgccatgtga cctggaggtc acgggttcaa 25560
gccgcctgcc ctttttagtc cgagcaacat agcttgagta taggaccttc gccgtatctc 25620
ttactatttg taaataatat aatattatta taatattttt attttttaat tttatcttca 25680
tattttttat tgtggtggtg ccctaaccaa cttacgcgca ccttgactag tctatgggat 25740
aattgacatg cattgagtaa ctctacttac taagatttag gcagatggca agaaatcacc 25800
tagttttttt tgcctccatt gggatttgaa cttgagacct catgattctc ctcccacttc 25860
attggccact aaaccactcc tttaggtata tttttttcat tatcgaggaa agtgtaattt 25920
tacggaaaag taaaaagctc cgtgcaaaag gaagtaaaaa atagagaatc tatataaata 25980
tgtgattatt taggaaagac gccaatcttc tatgcaaata ggaatctcat tggtgtacca 26040
aaaacacatt aaaaaaagag aggctattcc tcaaacgtca aaacaagctt tgtcccttta 26100
agagctctgc tctttctctc tccatggtac ccagataagt gctaatagag caacatccca 26160
cgctcggtgt tagacccaac taaatagatc agccttcaca ttattgtatc tcgcaccatc 26220
ttaaagctct accactgacg taacgctacc tagcaatgaa gtaggatatg atccatgtca 26280
tctcctgaat ctttgcacat gaaataccaa ttgacgtgtg attctcctct tcaatttttc 26340
ggttctcaaa atcgctcctt tagtcatcaa ccaatcgaaa aagcacacat ttcttggagt 26400
ccttgggatc cacactggaa aacgagggaa acccgacttt tgcctagcaa gcaacttaca 26460
gtattagctc tttacggata tctgactcta actattgacc actccctaac tccgacctcc 26520
agtaatcttg gttgtctagc agtaaagtct ttttatagag catttcaagt agattttcaa 26580
tatctgccat ctttccatct cagatggttc cttcttaatc taagatccca aatacacttc 26640
cttcatgccg tatccagaga cttgttagac tatcatctct agttggcatg aatctctata 26700
gatgtttgga aaaatgatcc tcagcctgtt gtccctcgac tacctgtccc cctaaaagtc 26760
ctgtttctct cttaacttaa gtgagataca accacttaat ctttgttttc ataatattcc 26820
ttcaaaaggc cgcatcgaaa aggaacaatg atgtttttgg ttatccacct cctttccgtg 26880
gtgtcatatt tctgtgctac caccttccaa attcatgctc ctatgcagtg ttgaagtaca 26940
catattctct atgcagatga cacgctgctt aagtgcaggc ctgatgaaga cctactgctg 27000
catcggaaag ctatccttct gacctttgaa gctatagctg ggttacatat ttttttgaca 27060
agggctgggt taacaactat gggggcctag aagagtggtg aggatgctag cgttatgtgg 27120
acggcaacga cagaatgtat aagggaggcg gcgatggagg tgttagggat ctcgaagggc 27180
tactctagcg ggaaccgagg tgaccggtgg tggaatgaca tggtacaggg taaagtggaa 27240
gcaaagaaag cggcatacct taagttagtg gagagcaccg acgaggagca gaggaaagcg 27300
aacaaagaaa gatataatga agctaggaag gaggcaaaat tagcggtcac ggaggctaag 27360
actgctgcgt ttgattggct gtatgagtaa ctgggggcca aaggtgggga taagaagtta 27420
tttcggctgg ccagagcgag atagagaaag gctcgtgacc tggatcaagt taagtgcatc 27480
aaagacgagg aaggtcgtgt attgatggaa gaggcccaga tcaagcaaat atggcaatca 27540
tactttcata aattgttgaa tgacgaggag gacaagagca tcgtgttagg gggattgggg 27600
cactccgaga gtcaccgaga ttttaggtac tgtagacgta ttagggttga ggaagtcgtg 27660
ggagcgatgc gtaagatgag tcggagcaaa gcgaccggac cggacaagat cccagtagaa 27720
ttttggaggt acgtgggtag agcaggcttg gagtggctga ctggctgttt aatgttattc 27780
tcaggatgaa gaggatgtcg gatgagtgga ggtggagtac gatgagtccg ttgtacaaga 27840
acaaaggtga tatccaaaat tgtagcaact ataggggtat caagttaatg agacatacca 27900
tgaaaatttg ggagagggtg gtgaagggag ggtaaggaga gcggtgtcta tatcagagaa 27960
ccagtttggg tttatgccgg gtcgttctac tacggaagct atccatctta ttaggaggtt 28020
ggtggaacag tatcgagata ggaagaggga tttgcacata ctatttattg acctagagaa 28080
ggcgtatgac aaggtttcta gggacgttcg ttggagatgc ctggagatga aaggtgtacc 28140
agtagcttat attagggcga taaaagatat gtatgatgga gctaagactc atgttaggat 28200
agtgagaggt gacttggagc cttttccggt ggttatgggg ttacaacaag gatctgcgct 28260
catttcgttc ttatttgccc cggtgatgga cacactgaca caccatattc aaggggaggt 28320
gccttggtgt atgctgttcg ctgatatagt tctgattgac gagacgcgag gcgacgttaa 28380
cgagatactg gaggaatgga tgaaggccct ttagtctaaa ggtttcaagt tgagtaggac 28440
taagacggaa tatttggagt gtaagttcag cgatgtatcg gggaagcgga tgtggaagtg 28500
aggcttgact cacaagtcat ccctaagaga gagagagttt gaagttccta gggtttatta 28560
tccagggaga tggggagatc gacgtggatg tcacgcaccg tatcggggtg gggtggatga 28620
aattgaggtt agcgtctgga gtcttgtgtg acaagaatat actatcgaaa cttataggta 28680
agttctacag agcggtggtt agacccgcca cgttgtatgg ggctgagtgt tggccagtca 28740
agatttcaca tacccagaag atgaaagtag cagaaatgag gatgttgaga tggatgtgcg 28800
ggcacactcg gatggataag attaggaatg aggatattcg gaagagagtg agcgtggctc 28860
ccgtggatga caagatgcgg gaagcgaggc tgaggtggtt cgggcacgtg cggaggtgtg 28920
agcgcttggc tctggcagtt acgaggcgag gtagagggcg gcctaagaag tactgaggcg 28980
aggtgatcag gcaggacata acgcaacttc aaatttccga ggacatggcg tttgatagga 29040
aggtgtggag gtcgagcatt agggttgtag gttatggggt aggcgatcat ttctcctcgc 29100
tgcgccggct agtctgatag tgtttcgtct aggactgcta gcggtttttg ttgtgtttca 29160
cataatcttt tttgttgtcc gtcacatttt ggcctttcca tttatttgtt gtattttaag 29220
atggtgatac tatttttctg gtttctgttg tggttatgga tctactatct ctgagccgag 29280
ggtctcccgg aaacagcctc tctatccctt cggggtaggg gtaaagtctg catacatttt 29340
aacctctcca gaccccacta gtgggattcg actgggtggt tgttgttgtt tgttgttgtt 29400
gaccatgtta tacacaagcc agcagatgtc tttggctaca aaattggatg ctttcctacc 29460
aaatatttgg ggtataccct tgggtgctaa aggaacggat gttaatatat ggcaaagggt 29520
gattgaaact gtgaaaagaa attggcaccc tggaagaact agtacatatc ctttggagga 29580
tgattaacat taatacatga cgtgttggat gagattccta ctcatatatg tctttatttg 29640
ccatgcctca aaagtggaaa ggcaaatgga catggagaag caatttcctg tggggaggat 29700
gtcaagacaa cggaaatcaa gttgggtaca gtttcctggg ataagagatc tggagggttg 29760
gactaaaaaa ttttagaact tcaaaacaaa agcctgctga tgaaatggca ctggaggttc 29820
aatgatgaca aaaatgattt gtggatgaat cttgttattg ttaaatatag gaagaccgaa 29880
gagtggtgca ctgatagtgc aaaaggtgca tatgtagttt ctatgtggaa atatactaga 29940
aggctgtgag atgattcttt gataatgttt agtaaaagtt ggaaatagca agagagttaa 30000
aatgtgggct gagaagtgct ttggtgatac tcctctatgt gagcaattac ctgactgtat 30060
gcaattaccc acaagaattg cactattgct gactgctatt cttctggttt attgatatta 30120
tattgagaaa aaatctacct tatcaaataa ataaataaat tgagaagaga tctcaatgat 30180
tgggagtttg agcatgtgaa ggaactaatt taaaatttga aactgtaagg attgattaac 30240
atatagcaga ttctttactc tggaagggta aagcattttc tgtcagggca tgctacaaaa 30300
ctgttgctaa aaattggagg aagccatgta aattagccat ggaggataat tcgagtgact 30360
gtcgcagccc catgttacct gcttcacctg gactgcaaat catggtgcct atctcactca 30420
tgaaaaccta caaaataggg gctttactgt atgcagtatt ttgtgcagga gcggctgaat 30480
ctgttgatca cttactgttc cattgcattt tcatcaagca gatttggtct atttttattt 30540
ctgggaataa attgtcatgc agaagcacaa tacaggcctt aaatagctgg tataatcaga 30600
cactagtgag gggaagcaga ttctactgga atgcagtgtc tagttgtatt tttctggaac 30660
acacctggtt agagagaaat gtttctctgg aaaaaaagaa ttcatttctc atttagagtt 30720
taggtgttca aatattctct atttgtggtg taagaaagat gtaactgatt ttgcttcact 30780
aattgatctg atgtattcct tcaatattta ggaggaaaag ctcattcctt ctgtactctc 30840
tcttcttgtt actcattaat aaaatctcta caacaacaac ccagtatatt cccacttagt 30900
ggggtctggg gagggtagtg tgtacgcagg ccttacccct accctggggt agagaggctg 30960
tttccaaata gacccccggc atccttccct ccaagaactt accaccttgc tcttggggag 31020
actcgaactc acaacctctt ggttggaagt ggaggttgct taccatcaga gcaacccctc 31080
ttgtccttaa taaaatctct acattttctt ataaaaaaaa agaacctttt atttgctaag 31140
gtgttgttac aataaaacct ttgaactttc aaacagctga agttctttat aattatcaaa 31200
cgctttcaga atttaactac actatttaac tgaataatga tgttttagta atggcaaaaa 31260
caacgagata ggtgctttga tgattttata gcaaggcttt gctgatttta tttcttatca 31320
ggtatcagat ggatctttgt aaaaaagcat tagaggagaa tgttgttgta tatctgggaa 31380
cgggctgtgg gaaaactcat attgccgtct tgcttatcta tgagatggga cagctgataa 31440
ggaaacccca gaagagcatt tgcgtgtttc ttgctcccac tgtggcgttg gtgcaacagg 31500
tttccttatt tttgaatttt tttttggtca accttttaaa ttttatgata taaaagatga 31560
aaactatttt acatgaaatc agatggctga aatatcaaat atcttccttg ctattgaggc 31620
ggtatatgag agctttaagc atgtttccgc cagctatttt acacaattcc ctttttgtct 31680
tttctccttt caattgagtc tcttttttga taaaacaata attttgttga ttcatgggga 31740
cactaaaata gaagcgacaa ttttattctc ttatgtcacc ggcccaatca aagcccttct 31800
tttgggtgac cactttgatg ccgttgcgct ttctgctgct tcaaaggcac cacatatctt 31860
tccggctact gttctgatgg cattgctcct tttgtccagt ggctgttcca gctttgtatt 31920
catcatatta ttgagttttc aacttagctc tttacttatc gtatttgtcc atagaaattt 31980
ttattgattt tgtggctagt atgtacgcaa tattctacgc atatatggcg aaagaaattt 32040
tattaaataa ttgaagacta agtgtttcag tctagacaaa ataattaagt atatagagtt 32100
tttcgatttt gctgaaaatt ggtcaatggt tagcatgaaa aggcctatag acttacatct 32160
cgtagagaac aagaaagcgc tcttcaattc agaatgtcat ttgatatgtt taactaattc 32220
tctcttgtct cttcgttaga atcttattac ttcgattaaa cccattctgt tttctgagtg 32280
tactcttaca acttggggca gggtgggaat taaaaagttt gtccgaaaca tgataaagca 32340
tgggcataaa agttaatttt ctttttcatg tgcttttgaa attggaaaag caagccaagg 32400
tcatagaaga ctctattgac ttcaaagttg ggacatactg cgggaaatcc aagcatttga 32460
agagccacga agactgggaa aaagaaatgg aacagtatga ggtgagtctg catgaccttt 32520
ttttgttggt gatggacatc atctcctgaa tgttatttgt ttgagacaga accatgggca 32580
ttcttggtat gcaaacttcc gattacagat tttaatacaa atattctttg aaacttgaat 32640
aactgatgtt aggggtaaaa aaaaacttga attactgatt tcaactaaat taatgtattc 32700
ttaccttgtc caattacaat tgaaatctta cataattttc tgagcctttt gaagatagtg 32760
gatgatgctt atgtgcttga gaaagggaga ttctgagaag agcgacaagt acgggttgga 32820
actcctgtgt tacatgggtt attttgaggg tatcacggat actctgaaag aagtagaaag 32880
tctctacaca ttttggattt tttttgttta cagcacttag cttagtgtca ttgtgcatct 32940
atacatgaca tagatggttt gattgaggtt gttggatcct ttcacttttg ggtggggacc 33000
tacagttttt tgttctctct ttcgcaaatg ttgacgtcaa cacttgcttg ttttgtttta 33060
ttcatttaaa ttatccttta tagtcactaa gaataaaaac aggaatcaac atggtttctg 33120
ttaactatat gtagtagatt gactgaacca tgttatgtgt tatatactgt ggtcttctca 33180
tcttaggtcc ttttttgggc tgtgcatgag tgtggatatt agtgatggct gactgttata 33240
ctgtaacttt tttttgttga cactatgtga atgttttgac caacaaattt gcactttgtt 33300
tgttcaggtc cttgttatga cccctcaaat actattacat aatctttccc actgctatat 33360
caggattgaa tttattgctc ttctgatctt tgatgagtgc cactatgcac aagttgagag 33420
tgatcatcct tatgctgaga ttatgaaggt aattagctga gctggtgtta tacgctgcat 33480
gctttgtttt gtatgtagta gccttcttat tcatgtatat tatttttaac agatatttta 33540
caaacctgat gtagtaaaac tgccccgtat acttggcatg actgcatctc caatatcagg 33600
aaaaggtaat atattgtgct gtaatcttca ggtgtattgt tgcttttttg ggatggattc 33660
acccagtaac aatatgttgt aactttctcc aactagctgg atccaatcag atagctcatc 33720
agtaatttca tatgtcacct tcgtgtttta aacttgacaa ttttttttat aatttaaata 33780
aatttattaa tctagggaaa attgacaaat agtacttcac agtgcttgta agatgctaag 33840
ggattgtcat ggaatgtaag tgttatgaga ttcaacacag taattttcgg cagaatgata 33900
taaagtcaca tgggattgac atggaactca cacttgaggt tacttgataa tttttggcaa 33960
aatcatctta agtatagatg tcatccagaa atcaccatct gtcccagatt tgtgtctctt 34020
tcttgggttt tcaggggtca tttctctgga ccacttctta cttgttataa gcgaaaacgt 34080
ttttccatct tgtgagatct gtaagtcttt aactattact tcgaaatgat gaatttatcc 34140
ccttctccta tccatgtaaa attggtcaac ctgactgaaa actgactggg gaagcagagg 34200
aattgttgtt atgatatttt ctttgtctat gttaatgatc aaatatcact ggctgtctaa 34260
tatagccttg tatgagtggg aaaatgtccc tgtgtactct ttttacctcc tttttctaat 34320
agtgtctctc atctgcatat gtgtaatttt acctccttat gcatgacagt atgtgtatct 34380
ttgttacata gttgattctt aacgtcatga cctctatgaa ttctatttag aaatgggatc 34440
aacagaagtt acaggagtat tatcagaaaa taaatctgaa aatgccttca agttttctga 34500
ttttttgact tataaaaaaa actcatctga acagcctcgc tgccttcttg aaggtaggta 34560
aggtgtacat actaccctcc ccacatccca cttgtaggat tacactgggt ctgttgttgt 34620
ataaaaaaaa ctcatctgat ctctggggtc tgtgcctttg tggaaagaaa tctgcttgcc 34680
atgccatgca ttggtcaatt gctgtgacag attgatagtt cttgctatct gatctttgct 34740
ttcaatacta atcattcttc caggcgaaac tggtgtatct ttcctttaag ctacatttgt 34800
ttttggatgc tcctcaactc tcagatatta tgttgtcttc ttactattgc aggtgctact 34860
gttgaaggcc ttgagacctt acttcgctct aaggtgctac tattgtacac aagctttttt 34920
tccatcatca ataaattatt tttcttttga aaaaaaagaa aaagaaaaat aagaaaaaga 34980
aaaaggatga ccataaaaga ttacagtttc ctcacatcat tattatggga acaataaagt 35040
ccaaaaacag ttacttgtga aggatgggtt tctgtcatag gtttattagt tcttggagtt 35100
gttaagaact gtcataagat tgcgactcca atttccaagc tatcattttg tatcctgggt 35160
ttcttgctgt gggtgtttca ttgttaggta gcaaatgact agcttggcgg cattttacct 35220
gcctgggctg agctgggctg ctaatcttgg ttcataccca tactgttgta gaagtgtgag 35280
gtagagggaa ataggaccat taacatttct atatttaatt tctgtctatg tatgatcaca 35340
ggtgtattct gttgaagaca aggatgaact ggaacagttt gttgcatcac ctaaggtgaa 35400
tgtatactac tatggtcctg gcgccgcgtg tcttactaaa gcttactctc agaagcttga 35460
agagataaaa caccaggtat tatctggtca gtaatttaga tggctatttt ctaattagtc 35520
ttcgaataaa tactttctgg tgttttcatg atttgacagt gtgtgatggt gcttcacaag 35580
aaagcagttg atcatagcac actcaggaac acaaaaaaga tgctcaagag attgcatgga 35640
catctaattt tttctctgga aaacctaggt gtctttgggg cattacaggt tttgttgcgc 35700
ttcttcttgt ttgtccccta atccgttttc acaagtcctg atctttcatt actgttagat 35760
tatcggatat tttattgctc acatttaata ttttacttgt gttcccattt atattagaaa 35820
caattatcag gggaagacct gcccccacct tgccgccacc tccaacaagc aaacattata 35880
aatggtcttt ttacttgagt atcatttaga atttcattaa aacagagaaa cttgcgtact 35940
atatggaacc catgatttag gctcaagacc tgaccagatt cctagctctc ttctaaaaca 36000
aagtgggcag acgggtttga aaatcttgtg cagtttaatt gactctcttg acctggcata 36060
gagtttttgg cagttaggtg tagaacttcc gttctctttt tgtttttact ttcatactgc 36120
tgctgaagta gtatctacgg acatctttag gcacttcaga ttttattttt tgtgtgtatt 36180
tttaaaaaac ttcagctgga gagtccacat gcattaccct actttagaca ttatttcagt 36240
agagtatgca ctccagaatc ttgttggttc cctagttatg cttagcgtaa tttaagcact 36300
attaattcac agggaagaca tcacgatcta tttttattta ttagttttaa gacttacagt 36360
cggaaattca attctaagtt gcacccttgt tttggtgaag gctagttgca tcctcttaaa 36420
gggggatcac tatgagcgcc atcaaatggt ggaagctgat gttaatgcta gtgatgactc 36480
tttgtgtgac agatatctga gtcaggtcgc cacaatgttt acttctggtt gtgctaaagg 36540
tatgttttat tctattgtgg attcctgttc tatagctatt tgtattcttt ccatcattac 36600
aagtattcct atgaattcta gcttgaacaa gaattctatt cttactggcc tgatcatgga 36660
ttacttggtt caagaaatga aattagcaag ctctaaccat atcttactga cttgttaata 36720
gagatcaaga catttgaatt ggacgtctaa atcaatttat agcattccac tgattaagca 36780
gggtgttcct ttgccaaagc taaatttggg ttcttattcc ttcgtgttct tacaacacat 36840
ttcaccaatg acaaagaagc atacagggag gagaactagt acacctaaaa caagtaaatg 36900
aaattttaat ccagatatac atggatcttc ttaacgctgt atggggactg tagaaatgga 36960
aaggggacac tgtaggagga attgttgagg ttagatgaaa cggcaaatac acataggtga 37020
ttgccgctga ttttgccaag gaaggaatag tgtttacacc attggaggta aagttccaga 37080
ggaattctct ggctttatct tcaactgtgg tcatcgacat gccatcactt gggacaagat 37140
tcacttggag gaatagaagg acgatttcca ggattgatct tggtatcgac tgaatgggag 37200
ggaattcttt ttgtcactct acccatttgg catagggatc agtgttggat cattgtccta 37260
ttctcttaaa gaactggtgg ttagaaaagg ttatctccat caaatctgag aacatatggc 37320
ttcagcatga aggaagggat ggttaagaca gtgggatagt taagtacacg agaggaaacc 37380
acattttagg tagccaagaa gctcagaagt agaagaaacc tcaagaaatg aaacatggag 37440
atatctggca gagtagaaac aaacactaca gagttattac aggagtacat acattggagt 37500
aggtcgaagg tgatggttta tgcgagaaat aagagaatgg agggaagcgt gaaatcaaat 37560
atcttacgcc tgaatccttt tatgtgcatc atttactatc aacacatata gctatattca 37620
cccacttgtg gtcactaatg ctatattaca ttgattataa ctatatttgc atagcaaatt 37680
ttacacttaa ctgtcttata gtttgcttaa tgatgttggg attttgaggg aggaagttaa 37740
agataggctt gggcgacact actaccaaat ttcgttctgc tgaataatgg tgataacaag 37800
accaaattct tttcacctgc caatgcacgt agtggacatg gaagatgtaa tctcattgag 37860
aagatgcaaa tagatgacta gatactccaa ggaaaatgaa aataaagagt agattttgca 37920
ggcttatcta tccgttgtta tatgaggaat aggatgagca agggtcagga tttgatggta 37980
gtttttttga tgaagtaata aatttcatta aagaaagggc acacatgtca ggatttggtg 38040
gtattagttt ctagaaattc gacagcaggg aaatagagga gctagagaaa ccatttgaag 38100
ctgaaagagt ggaggtaggg gatgaagagt tgtttaggag acaaggcact ggatttgatg 38160
gtttcactct tgcctctttt aaacactaat ggaaaatggt aaacgacact gtttatagtg 38220
cgtgcgtcat ttttatcggt ttggtccctt taagagatat ttaaattctt tgttctttgt 38280
tctatttccg aagaggaaag caacagataa taaataagga ctttggacca atcaatttgg 38340
ctggaaagtg aacaatggta aatgtgttgt taatgagatt gagatttgtg gtgaatagca 38400
ttgtatccat tgcacaagat tctttcgctg gttgaagggt atggatgttc gtgtgatctc 38460
aaacgaactg acaaattctg tattgatctg tggaaagttg ggaattctgg ttaaactaga 38520
catgagaagg catgtgaccg tgcttgtggg actacgctgg gtatgttgtt gttgttgttg 38580
ttgttgtatt agtcgttatc cagaatggtt tcttggggaa agttgtagaa agtggagaac 38640
tagtgcatac ccattgcatg tgtgtgtgtg tgtgtgtgtg ttgttgggag caaaaagtta 38700
ttcggcagga agacctttgt gccgttgtta ttattgttta taatagagag ctaatgttat 38760
aatctgtagg tagtgaattc ttgagtgtaa tttcgggttg ttggaggaga gcatgacatg 38820
gaatatgtag cacatctatt gtttgcagat ggcactttaa tctttttgat ccaaacggag 38880
acatccattt cttatataga acacttgggg gttcaaagac aattgggcta cacttcaata 38940
tgataaattt ggaattaatt ccattagaag aggtgaaaaa aatgctaaga gactggagag 39000
gataggaaga tgcgatattt atcaaaagga ggaagagtct tcttaataga gtttattccc 39060
ccacataatt tgtaactttg ttcacaatcg ctattgcaat aaataaaaga atggagaagc 39120
taatgcgaga agttttatgc atggaaggaa gttatcattt gatgttcaat ttaccaatca 39180
agcaagaata taagctgcct tcgttttcag tgtgatgtta gcatttcaaa gaaaaaaggc 39240
tggacaacta gatgggaatc atgttgtgac tgaacaagta tgatgaatca agtttcagtc 39300
tgacagtaat ctttccacgc ctctttttac ctctctgtat aaagttagac ttgatttcga 39360
attttatttg ctttgcttta gggtctttta atgaagacta agggcatatg ataaaagtca 39420
attcctgcaa atataggctc aaataatgat ctgttccaac agaaatatca aagaaccttt 39480
gatctgtctt gtgctgtggc ttgtgtatat tcttgttgtt ttcctctgta tattactagt 39540
ctaacatatg ctttatcatg cagatggtat gaatcctgat ttgacacttg tggaagttct 39600
gaaggagcct tatttctcca aaaagctttt acgtctaatt ggaatccttt ccaacttcgg 39660
gttagtcatt atgtagctaa atgaataatt tcctgttcct gttctctgac ttattaagga 39720
tttataagta gctggaaaca aaatagtcaa ttccactttg aggggtgttc ttctgggtca 39780
ttgtatccga ttataataaa atcaaccgaa ggagtattgg cagtgaactt acttgataac 39840
ctattttcaa taaattcagt ttatgcatgt aaatttacta ttagaaaact ggaagcatag 39900
acaatatttc ctttaacagt tggtgtgttc ttttcttatg aaaactttat attcttttga 39960
ttgccatttt caagaatagt cccaaaattt ccattttgct tcaatgcaac tactcaaaga 40020
gtttaggggt gagggagatg catcaatgca aatgatctgt aacaatcagg ctacagtgtt 40080
aaaaatggag catgtaaaag taggttgtca tttcgttcca caaatgatta aaccgggtga 40140
attgcggcat gttttgtttg ctcggatgat taattaatag atattcttac aaagccactc 40200
agcaactctg gaattgagta tatttttagc aagttaggaa tatctaatat gtatgatcca 40260
acttgagagg gagcgttaag aatgtcaata ttacgaaatt gttaatatga caagaatacg 40320
taccttgtaa gtataggaaa agtttagaat ccatataatt gggtaattaa caataaggat 40380
tattttcttt tccttttttg gattacttgt agacattatt caaatcccag catgtttatt 40440
cctcaaataa gcactatctt tttcgacttc ttccagtgtt gggttccaaa attatgtagt 40500
cgatgcacca aatgtccagg cctggctgca cggaggtgtt agagtgcccc attttggttg 40560
tgaaataggt tgtagtctcc ttttatggtt tcaagcaacc ctcacatcaa gagctgactt 40620
ttgggttgag ttggacctaa tgtccatttt cttaacgtaa agtttctttt tcactttctc 40680
aatgacctcg ttccatatct ctgtcgattt ttgcaccata cccaatggca ttcccaataa 40740
gtagaaataa tccctaactg cagcctaaga tatcagccaa gtgctctggt ctcaaaagat 40800
tctgctcagt tatttgtcct atttcacctg atgacatctt tccttgccac ttggtttttt 40860
ccatgtcctt tgtttgtcct atgattagtg gaaaaagggc tataggaggt taaattatgt 40920
tataactggg gattctagaa agcggcacaa agaatgacac aggagatcta taacggttta 40980
aatgtgacct tctctgtaca ttttacatta tgctataact gagatgttgc ggtgatttgc 41040
agaagataat gaatttgaag ttaataagat cattagaaca agagaaacat aatgtattag 41100
tctgaaccac cctaaatgta ctgttaatca tccagcagct ataagcttaa tgctgtttgt 41160
tccaaataag actctttgaa tagaactata accgattaaa cctgacgtat tagtttatac 41220
atttgtacat gggaattaga aatttcaatt tctcagttta tcaaaatatg tttggagcag 41280
aagatcattc tacttgtact gatttttgtt cgtcatgatt ttaatcttaa cattttattc 41340
tttgccctta cagagcacag tatagggcct atttttaaag agcaccacaa tggggcctct 41400
atggagaatt atggaattaa tgccttgaat atgagtgttt atatttatgg acctaaccag 41460
ctagttagcc cctcagtttg ctctcagtta ctctaaaagt gcacccgaat agggccctga 41520
tggagaaaca tgaaatgaat gcattgacta caattgttca tatttttgga ttagcctctg 41580
tgcatttgct gccaattacg gtggtaccat ctgaaattaa atgttcaaca accatctgct 41640
tttgatcaca tttcttcccc taaaagttta ttcttcaacg tgatcttttg ccttcataat 41700
gtacctttac ccgttagaaa taataagaat ataatttgaa gtcattaatg tatgtttctt 41760
gctttcatac cataccttta cccaatacgt ataataaatg cttcattttg tttgatgtca 41820
tggatgtata tttctgcttc ttagtgagtt cagtcgctaa ggaattcgag agtcaacttc 41880
ataatctgca ttttggtatc tccctctctt tattttcagg gtacaaccag atatgaagtg 41940
cataattttc gtcaatagga tcgtgactgc gagatctctt tcttatatgc ttcagcatct 42000
gaaagtttta tcttcttgga aatgcgggtt tcttgtagga gtgcactcag gattgaagag 42060
tatgtcacga aaaaatacaa atatcattct caataagttc cgttctggtg aggtaatggt 42120
tctttgttag attctttctc tgctcgcttg attctcttag acagaggacc tctgggaggg 42180
caactccaag tttatgtttg attctccatc tgatagttcg tatgaaattg atcgcatatc 42240
cattgcttaa tttgacagct caacttattg gttgccacca aagttggcga ggaaggactt 42300
gatatccaga catgctgcct tgttatacga tttgatcttc ctgaaactgt tgccagtttt 42360
atacagtcta gagggcgtgc ccgcatgcca aagtctgaat atgcattttt ggttgatagg 42420
tatctccaaa ttttatgctt tctgtacctt attacctgtc aagttcatca gagcaatatc 42480
tctgacacaa acttcttggc agtgataacc aaagggagct taatttgatt gagcattttt 42540
caagaaatga agctcggatg aatgatgaga tttcttccaa gaaatcttgc acgacagtta 42600
tagattttca agaaaatata tacaaagtag atatgactgg tgcaaccatc agttctgcat 42660
caagcatttc gttgcttcac cattattgtt ccaagcttcc acgtgacgag tatgatcttg 42720
tactgaattt cacttgatat ttctgttttt ctttttctaa ttaaagttta ttctgttctg 42780
tatcacttat gtgtggattt tgctttcgga actcatatct tcatgggtta acatgatttc 42840
ttttctgttc gttttgcttc ttttgtaggt ttttctgccc caagccgcag ttcttctact 42900
ttgatgacat agatggaact atttgcaaat tagttttgcc ttcaaacgct ccaatgcatc 42960
aaattgtgag tgctcctcaa tcttctatag aagcagctaa gaaagatgcc tgtttaagag 43020
cctgcaagag cttgcatgaa cttggagcac tcactgatta tcttttgccg gatcaagcag 43080
atgaagacct gattcacgtt ttttctgact cagaaagctc agatggttag acaaaattat 43140
tttgataaaa gcattttcaa tatgctttat gttattttgg tgcttgttgt cattattgta 43200
atgttgatgt cataggcgaa gacgcacgag aagagctcca tgagatgatt gttcccgctg 43260
cctttaaaga accatggact gagacagaga gtcctgtttg ccttaactcg tactacatca 43320
acttttcacc ttgtccaatt gatagggttt ataaaaagtt tggcctattt ttgaaagcac 43380
ctcttcccca agaggctgag agaatgaaac ttaatctcaa cttggctcga ggtagatctg 43440
tagagacaga gcttattcca tcaggagcta ctaattttga gaacaatgag gttaactatt 43500
tgaccctctt ctagtataaa cagaaaggct ctcttcaata ttttgactac tttctcttag 43560
caggtacaac tagcagagaa gttccagaga atgttcctca agatcattct tgaccgctct 43620
gagttcattt cagaattcgt atctttggaa aaacaagatt atgttgactc agcttcaaaa 43680
tcttacctac ttcttccact caatttatgt ggacacaata aaatttccgt ggactgggag 43740
cttgtcagaa gatgcttgtc atcaccaatt tttgggactt cagtatatgc aggcaatagt 43800
gagatatcca aatttgatga gcagttgcaa cttgccaatg gttccaaaag cgtacatgat 43860
gttgccaata gtttggtata tgttccatgc aaggatacat ttttcttcat atctgatgtt 43920
gtcaaagaaa gcaatgcata cagcatatat aaagattcaa aaaaccatgt caaacactat 43980
tatgatacgt aagtaaatga ctttattttt gttctttgct taccagcttg gtttcctgtt 44040
cttttgttga ttctacctgc attcgcatgc gcatatgttt ttttctgtct actgtaaacc 44100
agaataggag ttcaagtatt aataaaatgg aaatgagccc ttggtctggt gtggcaaaaa 44160
ggggagaaaa tttacaaatt agatgcaaag agtatggcag ttagaagagt ttttgatgag 44220
gtcaattagc atttaaccgc ttgctgctgg agaaccaatt aaacaatttc ctcacatgta 44280
tttggaagtt ctttttttct tctggaattt tttttattat ggtcagtcac tatatgtcta 44340
ttttatactt tttgagcctc acttgtggga ttacaatggg tttgttgttg ttgttgttgt 44400
gagccttgag tactaacaga atttcttgat gtaacttcct ttaccctgtt tgatagggta 44460
aataatttaa ttaacgtggg ataactcccg tatactagct tgtttgggaa acttcccgtt 44520
attgatgtat ctttacttgt ttaggaagca tacaacctgc tttagtttgg gaaaggagac 44580
acttcttttc attgcaattg tgtaactctg cttgttttct tggttaccct aactggccgc 44640
taaagggact gtcatgctct tcttgtttag agctacattt gttttatatc ttctgatgtt 44700
gcttattgag gacatcttgt cctcttcctt tgcgcttagc ttaataatac ttttctcata 44760
aagaaaacat atatcttagt tgaagatctg atcattttta caaatatgta tcatgtatat 44820
tctaatgggt gagagatttc tcttacagtt ttggtatcca tctttcgtac cctgagcaac 44880
cactaataaa agcaaaacaa ctcttctgtt tggacaactt gctacgaaag aaaggctatt 44940
caggtaattg tttattattc aagctgctaa gttgagctgt ttctattgca aaactcataa 45000
agacttgtga tgcaagggag ggggattgga agaaagggtt ttactccgat acatgttgaa 45060
gcatattgtt taaactaatg ggcatctgct ttgaaagcaa agaaaccaca aactctacta 45120
tagaactcaa agtcagaggc aaaatcattg acagtagact attgagtgct gataaagttc 45180
tatctagttc tatttatttg tgagagagca tccaaaaacc ctagttcttg tgagaatgca 45240
ggggagaaaa atctactatt gatatttgtt ttaattataa tacaatgagc cctatttata 45300
caatacatat catactccta ttctatgtgg gactaggact aattcatatt atttacataa 45360
ctatttaaca atcccctcaa gccggtgcat acaaatctta tgtaccgagc ttgttacata 45420
tgtaactaat acgaggacca gtaagggact tggtgaaaat atctgcaagc tgatcatttg 45480
acttcacaaa ctttgtagca atatctcttg agagtatctt ttctctgacg aactgacaat 45540
caatctcaat gtgtttaatt ctctcatgga acaccggatt tgatgcaata tgaaggacag 45600
cttgattatc acacacaagt tccatcttgc tgatcttacc aaatttcaac tcattaagca 45660
aatgtttgat ccaagctagc tcacatgttg ccacaaccat tgctcgatat tctgcttctg 45720
cactagaccg agcaaccaca ttctgtttct tgctcttcca atacaccaaa tttcctccta 45780
ctaaaacaca atatccagac gttcatcctg cccagccagc ttctaattac gcaacaattt 45840
gctcatggcc tcgatcttca aacaataatc tttgcgtgga actgattgta tatatcgaag 45900
aatgcagaca actgcattcc aatgactatc agagtgagaa tccaggaact gacttaccac 45960
atttacagga aaggaaatgt cagatctagt caatgtgagg taatttaatt taccaactag 46020
ccacctatat cttgtaggat cgttaagcgg ctccccctgt cctggtagaa gcttagaatt 46080
cagatctata ggagtgtcaa catgcctaca acttgtcatt cttgtctcca caagaatgtc 46140
taaggcatac ttccgttgtg agattacaat acttgagcta gactgagcag cctcaatacc 46200
tagaaaatat tttaatctgc ctagatcctt agtctgaaag tgcttaaaga gatgttgctt 46260
caacttagta ataccatcct gatcattgcc ggtaatgaca atatcatcaa cataaaccgc 46320
tagataaata ctgatatttg aagcagaatg ccgataaaac atagagtgat tagcttgact 46380
acgagtactt accaaaccaa gctcaaggag actgctttag accatagagg gactggcgca 46440
accgacatac aaggccacta gactccccct gagcagcaaa accaggtggt tgcttcatat 46500
aaacctcatc ctcaaagtca ccgtgaagaa aaacattctt aatgtccaac tgatagatag 46560
gccaatggcg aacaacagtc atggatagaa aaagacgaac tgatgctatt ttagccacga 46620
gagagaaagt atcactgtaa tctagctcaa atatctgagt atatcctttg gaaacaagac 46680
gagccttaag tcgatcaacc tggccgtctg gaccaacttt gacggcatat acccaacgac 46740
aaccaagagt cgatttaccc gaagggagag gaacaagctc ccaagtacca ctcatatgta 46800
aagcagacat ctcgtcaatc atggcctatt gccaccctgg atgagatagt gcttcaactg 46860
tagacttagt gatagaaaca gaggacaaac atgatacaaa tgcacaatgg ggtgatgaca 46920
gacgatggta acttaaaccg acataatggg gattaggatt aagtgtggac cgtatacctt 46980
tccgtcgtgc aatcagttga ctaagaggaa acaaatccgc agtattagca gggtcaggtg 47040
caggacgtaa atcagctggg cctgatgctc ggcgcggacg acgatgataa gtcaggagta 47100
gtggagttgt agaaggttga actggactag gtggtgaaac tggagctata ggtggttgaa 47160
gtgcagctgg agttgtaggt ggtggagctg gagttataga ggaagatgga tgggagatag 47220
tgactgaatc tccaaaagat ggaattggta gcacctcaaa aatatctaag tgattacttg 47280
gaccttgtga agtatgattg ggtttcaaaa aaggtacatc aacagacata aggtactgct 47340
ggaggtcagt agaatcgata tcccttttgt gttctcgagt aacccaaaga tacgcactta 47400
agagcacagg gagctaactt atcttttctt ggagtaaggt tatgaacaaa acacgtactc 47460
ccaaagacac ggggtggaag agagaacaaa ggtaagtggg gaaacaggac agagaatgga 47520
acttgattct ggatggttga agatggcaca cgattaataa aatagcatga tctaagaact 47580
gtatcacccc aaaagcgcaa cgaaacatga gattgtatga gtagggtacg agcatgtcta 47640
ttctttcttt cagctatccc attttgttgg gatgtgtacg aacaagatgt ttgatgaata 47700
atcccatgag agttcataaa cttcttaaat ggggaagaca aatactctag ggtattatca 47760
ctacgaaatg tgcagataga aaccccaaat tgattttgaa cttcagcgtg gaaggtctga 47820
aaaatagaaa acaactcaga tcgatttttc atgaaaaata ttcaggtgca tctggaataa 47880
tcatcaatga aactgataaa gtagcggaat cccaaggtag aactgacctg actaggaccc 47940
caaacatctg aatgaactaa actaaaaggt gactctgctt gattatcaag acgccgaggg 48000
aaatgagagc gggtatgttt accgaattga catgactcac tctagagtgg acaagtgaga 48060
taaaccgggt accatttgct gaagtttgac aaactgggat gtcccaaccg tttatgtaat 48120
aaatatgttg aatcagtaaa ttgtgcttta acttctttcg gtgaaggcaa taggaatagt 48180
ggtagaagat aataaaatcg ccacctagta tattacagtg agaagtccag ttgcatagaa 48240
tttttcttgg gtgaataatg ctgaggcctg ttttctggct caaaacttat agaaacccag 48300
ggatttgaca ggagtatgga taatggaggg gagatacatg gttttaatgg ttattactta 48360
ttgaaaaaaa aaagatattt ggttttagag gatatctgca ctggtgtaat gtgccgagca 48420
gctccaaagg tgaagggtct atattttctt ctaaaacttc agtaagtcat ttgggactag 48480
cttcaccaag acatgacatg agaaaactat aagctttctt tatttaactt gccagatttt 48540
cagagtgtca gcttgttatt ccctcctgaa aatgagttta atttctatta tgcctattat 48600
tctgaaaaac acagtaactt aagtggtgta ttatttttca attaatgact ttcctctggc 48660
cctctacaca gagttgcgtg ataaagagga gcactttgtt gaactacctg ctgaaatttg 48720
ccagctcaag ataattgggt tttccaaaga tattgggagc tcattatcac tgttgccatc 48780
gatcatgcat cgtcttgaaa gcctacttgt cgctattgaa ctaaagggct gcctatctgc 48840
ttctttccct gagggaaggg aagtaacaat agatcatgta aggaattctc cgatcctcag 48900
tagctatgtt gcgcggactc tccaaaatgt tgccgcaccc gtgtcggatc ctccaaaaat 48960
gcactactct tggagaattt gacccacacc cgacgacact ttgggagagt ccgagcaaca 49020
tagcttagta gtatttctca atcaaacaca tctgttttac atttatcact tgttcatagc 49080
atatgaatca tgtcagatac agtacctagt ttactattaa ctgcctgaaa ctggaccagg 49140
ttcttgaagc acttactaca gagaaatgca atgaaccttt ttctcttgaa aggcttgaag 49200
tgcttggtga tgcatttctc aagtttgcag ttgggaggca tgtctttctt acatacgatg 49260
cctttgacga aggacagtta actagaaggc gctcaaacat tgtgaacaat tcctatctgt 49320
acacgatagc agtcagaaac aatttacagg tacatggtgt tgctgaaaac tctaaatgct 49380
agatatggac agactcctac agtgatatga cagcacatct tttatgttca gataagagaa 49440
tgcttgcttt ttcttgtttc aaaacatggc ttttgaattt ttgcaaattt tacattattt 49500
cattgtgaga aagtgcaaac actgccattg tttgcacaaa ctcagatgca cgtgtggctc 49560
tctcatctca catggcccca aaaacaaata aaagagcaga aatagaatat atcttgttga 49620
acttatcagg aaaaaaagtt catctgtgtt gattaatatg aggcctcgaa taatttgtca 49680
ttgtatcaaa taactttaat attatctcca ctaaactaat ataataacca agttaaattt 49740
actaataaaa ctttatacct agtcgataac cgtaaaatag aatgggacga agggagtaat 49800
aaatatctga tacattcatg agtaggtatt ggacgaaggg agtaattatt tgatacaatg 49860
acaatgaatt caaggtattg aaaatgtgaa attttgtata aacatggtat gggctaaaca 49920
tttcgagata ttaaatagaa agactaccat ataaattgag attaagagag ctataagatt 49980
tgatgatctc ctatccaacc aagtaaagag gggatttcct gtgtgtctgg aacagtaaac 50040
atttttttaa aatggaacag taaacttttt tctatgcata catttaacac gttaaagata 50100
gtgatatttg attagctgtt aatgaatgct tttttgtggc atcattggaa aaattagtcc 50160
tactaagttt ttttgatgtt gccttgatgc accttaatat tcagtcatcg ctgacatttt 50220
ctttcctagt atgaggaaat gttttactct tgactgtcac gagtatgctg ttcgctgcac 50280
aaatatctga atgttgtcaa aagcaagcca taaagataaa atgaacatac tcaccatgct 50340
aaaatgactt cctcaatttc taataaccta tgttgttgga ttctcgagtt ggacagttct 50400
gcatttttct ttttgtgtga taaataagac agctagcatt ctgtatctca ataattgaac 50460
ataaatatga atataagatg aaactgcata tctctaatga attttagaaa tcagaggcaa 50520
ttgtggtttc ctatgagggg aggaggtcat agaatataca ttaatgtgac tgtatgtgtg 50580
taaatatgtt tgattacgtg tttaattttt tttttttttg tgagctttct ccttttaaga 50640
tgtttatact cttaagtcaa ttgatttgat tgaatctcta agtttttctt tgtgtcaggc 50700
atttattcgt gatcaatcat ttgatcccaa ccacttctat gcagtaggcc gtccgtgccc 50760
tgtaatctgt gacaaacaaa cagaaaaaaa catacacggt caatgtggta gtgtaacaga 50820
tggtgcaaag actgaagtta ggtgtagcaa atgtcatcag tggttgcgta agaaaacaat 50880
tgctgatata gttgaagccc ttgttggcgc ttttatagtt gacagtggct tcaaagcagc 50940
aattgcattt cttaaatgga ttggtatcta tacagatttc gaagaatcac aagtaaagag 51000
tatttgcgct gcaagcaaag tctttatgcc acttgctgat gaaattgata ttccggccat 51060
tgaaaattta ttaggttatc cattcgtcca taagggtttg ctcattcagg ccttcatcca 51120
tccatcttat aacaaccacg gaggaggttg ctatcaggta tggaatttct ctttttcaat 51180
aacctacttt tctgaaactc tctggttgtt gtgtaggcga tttttagtac tttgcagcaa 51240
cttctttctt agaacatttg atttccttta gcagagactg gagtttcttg gagatgctgt 51300
cctcgattat ttgatcacat cctatctata ctctgtgtac ccaaaactga agcctggcca 51360
gttgactgat ctgagatcag tttctgtaaa caacaacacc ttcgcagttg ttgcagtaca 51420
tcaaagcttc cacagccata tactctgtga ttatagtagt ggcctccgtg agtcaattac 51480
tagatatgtc aatttcattg gaagaccaga ttctatgaaa aggttggctg aagagccatc 51540
ttgtccaaag gtattcacta tttacatgat gaaatcttcg atattgatgg attcatggag 51600
tttcttatac agagtttata atagtttgtg tttacactta ttgtagtata gagtatttgc 51660
ccttcatcaa ataaacgtaa gaatttacat tgcaaagttc tcccataaaa gaattcaggt 51720
ataagacact tgggtcttca aatcatttga tattattgct agatagcaga ttgattatat 51780
atttaggcaa aacgacattg tctccacaaa taagggtaac gctgtacttt gtaaagtgat 51840
gtgaaaggtt tcaggtgtaa ggcgtatgtc tctgtcattc tccttttctc ttattttttt 51900
tttttttttt caaattggta acatttttgt attagatata aacatgagta cactaattca 51960
gtgtagtcat ccataattac aaaaggaagt acaaagagag acagactaag tctctataaa 52020
gcttgtgaga aggcacggga gaaaatatga tatattgata ttgtgtgtga tgcaatacaa 52080
gaggtgctat ttatagctac tctatacaaa ggggatacta ctcttattcc aatgtgggac 52140
aattacatan aattcagtgt agtcatccat aattacaaaa ggaagtacaa agagagacag 52200
actaagtctc tataaagctt gtgagaaggc acgggagaaa atatgatata ttgatattgt 52260
gtgtgatgca atacaagagg t 52281
<210> 66
<211> 127560
<212> DNA
<213> Nicotiana tabacum
<220>
<221> misc_feature
<222> (9391)..(9445)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (20735)..(21018)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (38289)..(38304)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (44066)..(44204)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (56787)..(57063)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (57340)..(57340)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (58066)..(59511)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (70482)..(70482)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (72737)..(72737)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (86876)..(87368)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (99516)..(99516)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (105463)..(105463)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (111794)..(111912)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (121063)..(121063)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (126389)..(126493)
<223> n is a, c, g, or t
<400> 66
cgttaactta tattttgcag aattaatatt tacaaataca ggaatattga cgggaataac 60
agtgttctcc gaagtactat tgacagagat cctcctttgt ctgcctgtaa aatcactcgt 120
ccaatgcaaa tgcatataaa gaaaatggcg ttctttaatc tctagtcctc actttacacg 180
cctcaaaatc tcccgtttca gtcctgcaag tggaatcatc ttgtaccatt catggtttac 240
atgtaacccg ttttacaaat ttgtgccttt tttaggccta gaaaatccaa ttccaccacc 300
attccataaa ttcccttttg cactacatgg acttttgctc tgttgcacca ttcattattc 360
tttcacgttt aatcaggact acttcatatt caacccgact actcagcaat tcatcacact 420
tcctattata cttatgggga tgagttttag cctttgatcc ttagaaatcg ccttgttata 480
aaattatctg cctccgaatt tctaaattgg aacctgagat cgctcagatt gagatttact 540
catccgaatc aaagaaatgg agagtctcag gtccatatat atttgcctat acgccatgat 600
ataagttaca ctactggaat gaagctattt atttctcata taacgaatgc ttcaatgtgg 660
aacaagaaat atttgaaaca attctcatgc ctaattgcag gaatggacaa ggccgggatg 720
ttgaggatca taagattgtc tattttgggg aatcttatgg ccatttgcac ttaatacaag 780
tgaatcgcca gaaactaact ctgtacaatg tttacgagat gaaaaataat ggtactaaat 840
cctcttttcg actctcgctc tttcaacgtg agtgttgctt tgtgcaggaa gttcttttag 900
taggcgtttg catgattgga attggaaaaa aagaaggaaa aaaaaaaaga gaatttgaag 960
ttgaataaca ttattcgaaa ttagtttgga catgaatttc acttgaaaaa aacaaagttg 1020
tatgtgtgta aaaagcatta ctcttattcc actgttttta ctcttttcaa aaaaagtttt 1080
taatatttca ccaatattgc aaagaaactc aatatctgca gataatgatg tccaaaccat 1140
tacttaatag aagtatttgc agattgtgaa cttcaatatt tacaaataat gaaatatatt 1200
acgaaactga tcttcctttt caggaaaaca aaaggcagga taatttgata taagcatgaa 1260
taatgatgcg aggctatttt atggtaagtg aagttgtaga tgaaaagatc actttctaca 1320
atattaacaa gatgaaaagt gatggcacat agtgtttttt aaaagaagta actcaaatag 1380
tcgtccaccc tatcacttaa attaaaaata gccggtgaag atataatata tgcataattc 1440
atgtattaca tgtgtataat tatgtatagt caatgtatgt tctatgtata tagctagaaa 1500
acgtaaacaa ttaatatggt tatttatatg tgtaaagatc cctttttaaa ataaaaaatt 1560
ttacttccta tagcaaagtt ttacacctta tttattataa ataaataccc ttttaaaata 1620
ttattttcta tagctacctt ttagttttta tagcaaaata tgtatttatg gccacttcct 1680
accgttaagc cattaaatat actgtctaat atttttctct ccttctttca gttttttctc 1740
tcccaaaatc accgtatagt atcaaagttc tctctccact atctctctct cacaacgcca 1800
ttttcttccc cattctatag ccacgattct ccttttatca tcttcattgt ctctctcaat 1860
tttcaatatt ttttgctcca aaatattgtg gtaagtgtta aagttgttag ttttatgcta 1920
gtactgtgct tcttcttttt ctctttacta atttttttaa aatattcacc attgttatgc 1980
tttcaccaga aaacttgaaa tttcctattc caatagctga ttcaataact ccgaagaggg 2040
ttacccgagg tatacccacc aaagcactca attttgatgg gccatctttc gatttgcaaa 2100
tcaatcaagc ggaacatgta tttgcaggtt cagcaacaac aactgttgca gaaaggagaa 2160
taaaaatacg caatgacaca ccgaaacaag gccaatttga gaaatcttcg aaagaatcaa 2220
tacttcctga tgcggaaaag aaaagaaaac ttatggatga tgcttcaggg ggtaagggaa 2280
aagaggtcga tacaagaact agctcgaaaa caccgaacga aaaggtaatt gtagatatat 2340
ttatatgtat ttgagtccgc atacattgat tattaccttt tacaatagtt ttctcttctt 2400
gtatgttgaa gtatttatat gtattcaata gtgcctacac tgatttttac ttattacggt 2460
gacttttgac ggttgtattt agatgtattt tagttcattc aacaactttt ttaaatgcac 2520
tagttgttct aattttacct atgtattcca actaagtgtt ttcatcttta ttttcaagcc 2580
aactgtattc tgttgtattt aaaacaacag tcattgtcac aactcatatt ttttgtggta 2640
attatcaata cattatgttt gtaattcatg aatgagttat gtattctaaa taattgtatt 2700
catctatatt ttcaaccatt tattttatct ttttaatttt tgttgtatgc atgaaataaa 2760
actctttgtt aaatacccgc ctattgtatc atcgcatatc aactcctaca ctaatacaga 2820
catagtctcc gacctcaaag aaaagcttac tccaaagcaa tacaaaatat tttgtacttc 2880
ttattttgga agtttcctcg atatgaagca ctgtgaggtt caacatcaat tgttcaggtg 2940
cttcatggtt atggagctgg aagaaatcca tgatgattca ttttcaatat atgtgaatgg 3000
tacaacatta tgctttcaat cagggagttt gtggtagtta ttggtctcaa ttgtgttagt 3060
gacgctggag atttttagtt taacacaaag atgcctaaca ggatgcagat acatactttg 3120
gcggtgcaaa gaatgtcaag aagaaagatt tgttgaaatg ctttgatgac aagaattggg 3180
gttatgacaa cgatggagat gccattaaaa taattatgtt gtatttcata catactttca 3240
tattatccac cgagaagaac tgcacaacca tcccaagact acattttgac ttggtcaaga 3300
gcgggagata ttctgattat ccttagggta aggatgcatt ccaggccctt attagatcta 3360
tgagcacgaa gatggattct tagaagaagt attacaggat agctgggatg cctctcgcta 3420
tgcaactatg gttctacgag tgttgttcaa aggttgatcc caaaattgca ctccgagttg 3480
ataaccgaat tcccagaata ctcaattgga aattcacagt caaccagcca acttgatgaa 3540
tggcatgttc aatgaccagg aaaacttggt aatttactat tatttaattg actggtattt 3600
tagtcagcat atatttctgt tagtaaaagc agtgctgaat ttaaaaataa aatatagttt 3660
aatacatcat acatcaatgc acatgttttc ataattaagt ggaatacaac agaatacata 3720
atacagtgtt aaaattaaaa attaaataca gttgcataca tcatacatta atgcgtactt 3780
ttcaaaatta actagaatac agtagaatac ataatatagt ttacaactac acatttaatt 3840
caatgatgtt aattttgtat acaatacatt tatatagata attttccata tacataaagc 3900
atattacatt agtaatcata catcaagcgt gatttacatt aagtgtattt ctattttcag 3960
atgaaataca acaatattta accaaacgct agagagcttg ttgttattca ggtttctccg 4020
gatggcgttg atgtagacaa aagtcctatt catatagaca acaatgaata tgattttgat 4080
gactttagtc ctacaccgcc tcttcagcct aagaagaaac gtgatgcaag cgtttgtcta 4140
tcttcatcac cacctcacaa aaagcgcaaa caacagctaa ttgatatctc aactgcagag 4200
ggtccaattc cacatgtgac cgcaatacct caagccaagt ttcctcctac tgctaatatt 4260
aaaataaagg aaactgtatt gagtgttaag aagccagttg attctaaatc tgatgatttg 4320
tctgctttga ggcaagacct aaattcattc aaggattatg tatgtattgt taaaacatat 4380
tcaactttat aatttttgta ttaactttca tatatgtttc taacccttct ctaattattt 4440
gagtaattat taggtgatgg gcaagttcac ttctctacga tcattgatca ataaaaattt 4500
taaaaagctt tctgaacatg ttaaagccaa tcagaataca aaaagggtat accaaagaaa 4560
aaaataaact aggagacata atggtggtat tcaaatgtca atcgaagcca acttgcatga 4620
taatcccaaa ggccgagcac aacatgatat aactgttggg gagaattcag aggttaataa 4680
tttttaacct ctttagtata tatgtagtat aatgatacat gtgcaatcaa tgtatttata 4740
tgttgctata actatattta tgattttcaa aatatagtta catgtgaata caatgttata 4800
tctgtattga tgattttcta aatacatatt gtaaaatagc ttttactatt ctttagttta 4860
atcatgtata caataacata catatttcag aatacactta tatacatata aatacattgt 4920
tatatatgta ttcatgattt tctaaataca tattataaaa taatttttac tattcttcag 4980
tttaatcatg tatacagcaa cataaatgat tcagaataca cgcatataca tgtgaagaca 5040
ttgatagaat ttaagtttgc acacctacta tgaacttatg aagaaatatt tttaatctaa 5100
tctgataaat acaattcttt aaaatatatg ctatattaat gtattctatt aggtgtatgt 5160
taaggctacg gaaatgaagc tgaacacaga cattcatgcc gatgaacatc catatgctat 5220
tttaactaga tacatgtatt tctctggata catccaaatc aaattatatt aaaaatattt 5280
attcataaat tcatagtagg tatacggact tgtattctgt caatgtattc acatatatat 5340
gagtgtattc tgaatcatgt atgttgatgt atacatgatt aaaatgaaga atagtaaaag 5400
ttgttttaca atatgtattt aaaaatcacg aatacatata taacaatgta tttacatgta 5460
tataggtgta ttctaaaata tgtatgttgt tgtatacatg attaaactga agaatagtaa 5520
aagctgattt acaatatata tttagaaaat catgaataca gatataacac tgtattcaca 5580
tgtatataaa tgtattctga aaatcatgaa tatagttgta gcaacatata aatacattga 5640
ttacacatgt atcactatac tacatatata ctaaataggt tttaaaatat taacctctga 5700
attctcccca acagctatat catgttgtgc ttggactttg ggattatcat gcaagttggc 5760
ctcggttgac atttgaatac caccatcatg tctcccaata tatttctatc tttggtatac 5820
cctttctata ttctgattgg ctttaatatg tttagaaagt tttttaaaat tttcattgat 5880
caatgatcat agagaagtga actcgctcat tacctaataa atacacaaac aattaaagat 5940
aggttagaaa catatataaa agttaataca taaactgtaa agttgaatat attttaacaa 6000
tacttacata atccttgaat aaatttaggt cctgcctcaa agcagataaa tcatcagatt 6060
tagaatcagc tggcttctta acactcaata cagtttcctt gatttcaata ttagaagtag 6120
gaggaaactt ggcttgaggt attgcagata catgtggaat tgaactctct acagttgagg 6180
gatcaattag tttttgtttg cgctttttgt gaggtggaga tgaaaatgga ctaacgcttg 6240
catcatgttt cttcttaggc tgaagagacg gtgtaggact aaaatcatca gaatcatctt 6300
cattgttgtc tgtatgaata ggacttttgt cttcatcaac gccatccaga ggaaactgaa 6360
taacggcaag ctctctagcg tttggttgaa tgttgttgta ttttatctaa aaacagacat 6420
acactcaatg caaatcacgc ttgatatatg attactaatg taatatgctt tatgtatatg 6480
ggaaattatc tatataaatg tattcagttg tattgtatat aaaattaaca atattgaatt 6540
aaatatatag ctgtaaactg tattatgtat tctaatgtat tccagtttat tttgaaaagt 6600
aagcattgat gtatgatgta tgcaactgta tttagtttta aattttaaca ctgtattatg 6660
tattctactg tattccagtt aattatgaaa acatgtacat tgatgtatga tatattaaac 6720
tgcatttcat ttttaatttc aatactgttt ttactaatag aaatatatgt tgactaaaat 6780
accagtcaat taaataatag taaattacca agtttcccta gtcgctgaac atgccgttca 6840
tcaagtaagt ataagttggc tggttgactg tgaatttcca attgagtatt ctggaaattc 6900
ggttatcaac tcggagtgca attttggagt caacctttga ataacactcg tagaatcata 6960
cttgcatagc gagaggcatc ccagctatcc tgtaatactt cttctgagaa tccatcttct 7020
tactaataga tctaataagg gcctgaaatg catccttacc ctatggataa tcagaatatc 7080
tctcgctctc gaccaagtca aaatgtagtc ttgggatggt tgtgcagttc ttctcggtgg 7140
ataatataaa agtatgtatg aaatgcaata caactatttt aatggcatct ccaccgttgt 7200
cataacccca attattgtca tcaaagcatt ccaataaatc ttttttcttg gcattctttg 7260
caccatcaaa gtatgtatcc acaatcatgt taggcatctc tgtgttaaat tgaaaatctt 7320
cagcgtcact aacacaatta agaccagtaa ctaccgcaaa ctccctaatt gaaaagtata 7380
atattgttcc attcacatat attgaaaatg aatcatcatg actttattcc agctgcagaa 7440
ccatgaagca cctgaacaat tgatgttgaa cctcatagtg cttcatatcg aggaaacttc 7500
caaaacaagt agtaccaaat attttgtact gctctggagt aagcttttct ttgaggtcag 7560
agactatgtc tgtgttagtg taggaactga tatgcggtga taaaataggc gggtgtttaa 7620
caaagagttt tattttttcc atacaacaaa aattaaaaag ataaaataaa tggttgaata 7680
tatagatgaa tacaataatt tggaatacat aactcagtca tgatttacaa atataatgta 7740
ttgataatta ccacaaaatg cgagttatga caatgattgt tgttttaaat acaacataat 7800
acagttggct ttagaataca aatgaaaaca cttagttgga atacatagct aaaattagaa 7860
caactagtgt attttaaaaa gttgttgaat gaactaaaat acatctaaat acaaccgtta 7920
aaagtcactg taataagtaa aaatcagtgt aggcactatt gaatacatat aatgacaaca 7980
acatacaaga agagaaaatt attgtagaaa gtaataatca atgtatgcgg actcaaatac 8040
atataaatac atctacaatt accttttcgt tcggtgtttc tgagctagtt cctgtatcga 8100
cctcttttcc cttaccccct gaagcatcat ccataagttt tcttctcttt ttcgcatcag 8160
aaagtgttaa ttctttcgaa gatttctcaa attggccttg tttcggtgtg tcattgcgta 8220
tttttgttct cctttctgca acaattattg ttgctaaacc tgcaaatata tgttccgctt 8280
gagtgatttg caaatcgaaa gatggcccat cgaaattgag tgcattggtg agtatacctc 8340
gggtaaccct cttcggagtt attgaatcag ctattggaat aggaaatttc aagttttctg 8400
gtgaaagcat aacaatggtg aatatttaaa aaaaaatagt aaagagaaaa agaagaagca 8460
cagtaccgca aaaaagctaa taactttaac acttaccaca actttttgga gtaaaaaata 8520
ttgaaaattg agagagacaa tggagaagat aaaaggagaa tcgtggctat agaatgggaa 8580
agaaaatggc attctaagag agatcatgga gagagaactt tgatactata cggtgatttt 8640
aggagagaaa aatgttagat aacgtattta atggcttaac ggtagggagt gaccaataaa 8700
tacatatttt gctataaaaa ttaaaacgta gctatagaaa ataatatttt aaaagatttt 8760
tatttataat aaataaggtg taaaactttg atgtatgagg taaaattttc ttttatttaa 8820
cacactttaa tccactcaaa tttttgaccc aacccgtccg gttaatctct ttgctcttaa 8880
taagagctat aggtagaatt ttttttaaaa agatacgagg agatcacaaa atataaagga 8940
gggcaaatag catacctcac tagttaccat gcaaaggaag tgcatcttgt gttaagaact 9000
aaccaaataa atcgctgtaa aaatgttggg cgaatgatat gaatattcaa attatttaat 9060
gattcaatga ttaaacagtt tcttatattt ctttttatta tcaatttaca ccttcacgat 9120
gagtttttga aaaagggaaa acataaatgg tttaattttg tcgatgtatt attcgaaatt 9180
gctctatttt atcaatcagt taaataattg taactctagc tctacaattc attgagcttt 9240
gcactaaact ctctcacacc catccaatac tggctttact agtgtaacga tatcactaca 9300
tcaaataaca atcaaaataa atattatatt taaaataaga atactattca aattatcaac 9360
aacaaaaaaa aaaaaaaaaa atgtaaaggg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 9420
nnnnnnnnnn nnnnnnnnnn nnnnnaaaaa aaaaaaaaaa aaaatgtaaa gggctacaca 9480
gactagtact attggtcgat tagtctttgt cgtagaatag aaagttcttt gtccatttgc 9540
tttctcacag ttttaatata ataatggagc ttttcttaga gattaagctt ttaaaagtat 9600
tcctctccac atcaaaaaca aaaaatgtat tattattcca ctagtgagta gtgacttgtt 9660
cttccttgga gaccaaggtt tcaacagttc ttcctctcca cgtcactgaa aaataatatt 9720
ttattacgat ttttaaaaaa aataaaaata tattttaaat tattaaatat gtagacagac 9780
atttaatttt cataccccaa catttcttat gtaatatttt taaaatttat gttcaaattt 9840
cacacaaaag attaaatgtt ttaatcccca cactttgaat tccttcacaa ccattttaaa 9900
acaatgagtt taaataagac ttaaaatatt ttccttaaat cttatttagc cgctttaatc 9960
actaattaaa cagaatatat tgaccttaga ataactaaaa cccttatccg aatcttatcg 10020
gttagtagag cgttaggata ataaatttca caaactcata ggtactctaa tacaccttaa 10080
atattaggag atggctatcc tttgtcaaac cataaattaa ttgtattttg ttattggtcg 10140
atagtgtcct ttagtctttg tcgtagtata gaaactaaaa agttctttgt ccatttgctt 10200
tctctttttt ttctttcgtt tttgtccatt tgctttctca gttctaacat aataatggag 10260
ctttcaaaaa ataaaaatga attattccac tagtgagtag tgactaatgt ttacttggag 10320
accaaggttt caacagttct ccctctctac gtcactgaaa aataatattt ctttctatcc 10380
ataataagtg acattttgac ttttatattt tggttcaaaa taattgtttt tttacataat 10440
caacaaaaaa ttaattttat ttttccaaaa tttttcttta tttacatatt acaatgtgtc 10500
aaggtaataa ttaattaaag gtaattaagt gaatacatct ttttgttcaa ttttcacaca 10560
aaagattaaa tattttaatc ctcgttcttt gaatagaccg tggaagtata atatccacta 10620
gctataagcc ctttataatt tttttttggt ttcacaaaca tattgtctgc tcgtatcggg 10680
gctccactaa atttaaattt gtgtctcgaa attctacatt gaagagtgaa acatattgta 10740
ataaagacaa atttatatct aaagctcgaa ttcaagacca gatataaaaa agaaaagaaa 10800
tacttattac tccacgacaa ctttagctga tccatttata agttgttaag atcaacgtcg 10860
ttttccttga gatcaattcg attgctattt ttcctttttg ccgttgaaca aatgagaaca 10920
ttttttcttc ccgtttctcc tcaaatagtt gtatgacact gcaatttttc caaaaagtga 10980
tgttactctt tggttaatat cttaacttat tagttttctc aacttaaaag taatgtaata 11040
atatttacat cggcatcttg ttagagccaa tataataaga tcttcaaatt tgtaaaatta 11100
aaatatcttc aaattgttag aataccgata ataatatgtg ttaggttaga ggtacgtaaa 11160
tacatttcgc gaaaatactg actggttttc gagagaccta ctaacctcga ctaattcaga 11220
tacactatct cttaggttcc atttaagggg atgcgcgttc taccgataat ttggttatta 11280
caaagctcaa attttatttt tgtcagaaag caactaatta attttttcaa tgtcatatta 11340
caagtcgaca caggcgcctg tgtaaacaaa gtgctttgtc ggtgaactat aaatatttca 11400
taatccgata ttaataatct tttatttaat caatttctga ccgattcaat agaatatatt 11460
tgaaattgga atagaaaaaa taaacaaaag aacaacattt tatttgtttt ttaaattctt 11520
taatctaatt aaagggtcat ccatccaata aaaaataact taagctcatt tacgaagatt 11580
tagaataggt cttttaatta aaggacccta gaatctgttt gtacgtcaca acttatacta 11640
gatcagtaaa aaggggcagc ctgatgcact aagcttccgt tatgccccgg ccggaccaca 11700
agtatttatt gtatgcaacc ttagaacttt aaaaaaatat atttcatatt caaaatatac 11760
tactatttcg aatttggatg ggtagagcac accgagtgaa atgttatttc atgcattttt 11820
cattgataat aaacaaactt aagtcatcaa aattatacac aacatactca ttgtgtttgc 11880
gtatatttat attactccaa cttagcatca cttctttaaa tgtaaggtct gagaattact 11940
aaattatacc gtgatgaaac aattaatggt cattagtaat taattgcacc acttaaattt 12000
tgtacatgaa atttttaaaa atgattattt ttgtttaatc atctgctatg ctatcagaga 12060
ctactggctc gattaattca aagtagcgcc gtatagagtt cgtttccttc attacaaggt 12120
tcgaatccaa aactctaatt aaaaatagag aaattaattc attatgtcac atagataaaa 12180
aaaaataaaa aaaatcagtt gtcccactac ctatgctaag acaaattaaa ggtttcacat 12240
tccttgcatt tgatatcatc tttagtaaag tttttttatt tttattgcaa actagtgaat 12300
cttgtgacaa tttttattta tttcaagaaa atcatgttta ttattgtcga aaagtaaata 12360
attaatttct caatgccact ttatggaaaa atccttagcg cgtgggtaaa ccaggtgctc 12420
tgccaattac attagaaata atacatgatc tggtattatg catctcttta aatagtattc 12480
tttagattag taattagtta taagtaatac gatatcagat atttataatc ttcaacaaga 12540
tttagtttta tttaaaacga taataactta cttaagcata tataaattta aaacaacttg 12600
acattatatt ttatttggaa gtcattcatg caaatggcca agaaccaaac aaataaatat 12660
aattttccta tatttctttt gaacctttta atatgtttaa tttaattttt cttcttttat 12720
ttcatggtga cgtgcactgc acacggaagc aagccgtagt aggcgtcagt tttttccttt 12780
tcccttgtaa caacggtcca tattcttatg aatattgaca aaaataccct tgtctttatc 12840
ataattccgt ctatacaacg aaaggctcac atgtcattaa acattttctt aaggctaaac 12900
aaggaatacg tttttttacc tcttatgaaa tttaaacaga atagtattaa aacttaatag 12960
gagtactggt ttttgtagaa gccataaagg gctacaatag actagtacta ttggtcaata 13020
atgtccttta gtctttgtta cggtatagaa agttctttgt ccatttgctt tcttagagtt 13080
gtaatataat aatggagctt tccttagaga ttaagatttc aaaagtattc ctctccacat 13140
caaaaacaaa aaatgtatta ttattccact agtgagtatt gactagttct tccttggaga 13200
ccaaggtttc aacagttctt cctctccaca tcactgaaaa atggtacttt cttcctccct 13260
cttacgtgga aatgttatta ttagggaatt aaataatatt ttattatatt ttttttaatt 13320
attaactatg tagacttaca gtatttttat ataattttta atttttatat atgtaaaagt 13380
ttcttagcag agataaggtc tgcgtatata ttatctaata ctattgagta tattattgtt 13440
gttgttgaat tcgcatggcg tagccgttta cagcacacca aatgatctga tatttcatgc 13500
attttttatt gatgacaaac aaacttaagt catcaaaatg tataaaacaa cattcacatt 13560
taaacagtac tcaactactc atccatatat gtttgcctcg tatatatatt tattaactcc 13620
tactttacat cacatattta aaagggctaa tcattactat aaattattta ctactctctt 13680
gccgtgatta aagaattaat ggttactagt aattagtgaa attttgtaca tgaaattgca 13740
agaggaatta tttttagaat gattttttct ttcttttacc atcttgtttt ctagagagct 13800
acgagcctcg actaatccat atagacatcg cttagggtct atttaaggga gaagcgggtc 13860
atacctataa tttgtttgtt ataaggctcg attcgaaata tctagttaaa agtgccactt 13920
gtaagactat tgatgctaag acaacgaatg tgatgacata aaatgtcatc tttaatttaa 13980
acattcattt ttgtgttcta tgacctcgaa tagtactatt catcattcct cgacttgcat 14040
gtgcggcccg aataattttt caggaagttt atatatgaaa aattgattaa aatgtgaaat 14100
agagctttaa aactcaactg agttgacttc ggtcaacatt ttgagcaaac ggactcagat 14160
tagagttttg acagttccaa taggtctgta tcatgatttg gaacttgggc gtatgcccgg 14220
aatcgaattc tgaggtccct aattcaagtt atggccattt aaaggctaaa gattttcaaa 14280
ttttgaccac ggatttgact ttattgatat cggactcata ttgagatttt gaaaattgga 14340
atagctccgt tatggcattt atgacttgtg tgccaaattt gaagtcattc tgaattcgtt 14400
taatatgttt aggcacgagt tttgtaaatt gaaaaagttt gaaactcata agttcgaatc 14460
gagttgcgaa ttgtaatctt aaagttgttt gacgtgattt gagaccctga ataagtctgt 14520
attgtgttac ggaacttgat ggtatattcg gacgaggacc cgagtactcc gagtgtgatt 14580
tagattgaaa tcggatcaaa acttggacta agcaaaatct gaaattttgg tgcttctagt 14640
gtcttcgctt atgcgaagcc ttggccacag aagcgagaaa tccctcacaa aagcggcttg 14700
ggcaaatggg aaaaaaactg taggtgggga accttgaacg cactcgcgca tccccaaaag 14760
cgaactctgc gatcgcagaa gcggaaggca acgcaaatgc acattttcct ctgcatatgc 14820
gacgttttgc ctagccaaca cttcttcgca taagcgaaat ttttagtcgc aaatgcgaca 14880
atttcatcgc agaaacgaaa gattggtaga aacataagaa tcgaaaatca gtcatttcgc 14940
catttttgtt caagttttaa aacctcgatt tatgggtgat ttgaaagagt ttttcacaac 15000
ttcgacttgg gtaagtgtta tatacccgaa agtaattata tttcataaat ccacatctat 15060
attcatcgtt ttatttcgga tttagatgga agaaattggt tttttttgta aaactttcca 15120
aaaatgaaaa tttaggattt gaaggtccat ttgacatcag aatttgataa tttttgtatg 15180
gtttgactcg tctcgaaata ggtgttcgaa tttcgctagt ttttccagta ttcgagaagt 15240
gggtcccact gtcaattttt aaaatgaatt ccagattttt aatctagaaa atttgtaaat 15300
tcatatagaa ttaattccta cgactcgtgt cgagtatatt gaattatttg tgactagatt 15360
taaaactttc agacatgaat tcgcgaggca aacgtttatt gaaatcgtga atttggttgc 15420
gaagcgaggt aagtgtcgtg gttaaccttg acttgaggga atagaaccct taaattattg 15480
ttaagtgaat ttcatgtgta atgatttaca agcgaggtga cgagtgccta tacgtcgtca 15540
aattgattgt ttgcataatt atctgaatat cataaattat ttaaaatcat gaattaatta 15600
ttacattgat tatttctctc atattccctg ttcaatatta tgtcttgaat tcatgctata 15660
attgctatat gcttaattga attatgtgta ttaattatta cttgatattt agcatattaa 15720
atattaaatt gcctattttc tccttgattt tcacaattaa ttgctacttg tcattactta 15780
tttttctaaa taaatcataa ttactgtatg ctttgttgcc taataatttc ttattaatat 15840
ggtatttatt ggagtatttt tatatttaag agttgttaaa ttatattgtt ggatcaggtt 15900
gcatgccaca acagatttaa tttaagttta tattgttgga gcaggttgca cgccgcaaca 15960
gaatttaatt gaaagattat attgttggat caggttgcac gccacaagag attttatttt 16020
aagtttatat tgttggagcg gattgcacgc cgcaacggaa attaattgag ggattatgac 16080
tactgaattg acttcaatta ttgatatgct ttactgatct tacttctatt cctgttatta 16140
ttattattat tattattatt attattatta ttattattat tattattatt attattatta 16200
ttattattat tattattatt attattatta tgtataggtt aatgtaagcg acctgcctta 16260
gcctcgtcac tacttcgtcg aggttaggct cgacacttac agagtacacg gggtcggttg 16320
tactcatact acactctgca cttcttgtgt agatttcgga gttggtccca atgacgtact 16380
gtagaattgc tcagatttag ctatcagagg agacttgagg tatagatgca cgacgttcac 16440
aactctgaag tcctcttcta ctttatctta gctatgtgct tttttttaga caattttatt 16500
ttatttagac ccttgtttgt attattctag aagatcatgc acttgtgact ccaattttgg 16560
gatgatattt agacatcata ttatttttgg tttgcacatt taaattcaga tattatttcg 16620
attgttgggt tttttattat ttaattaaaa taaattgtta aaaataattt aaattattct 16680
aacgttgcct tgtctaacaa gtgaaatgtt aggtttcatc acggttttga atgtgggaat 16740
ttcgggccgt gaaaacaaat tcacatcatt gcaagtgatc tcatgaactt tatcctaaaa 16800
cgtttcttgg gttgcaaact cgtgaatcta gtgacggttt ttatttcatt tcaagaaatt 16860
caatttttat ttttgttaga aagcaactaa gtaattttgt caatgtcata ttacaagtaa 16920
acataggcgc ccgtgcaaac aaaatgctct gccattgaac tataaatatt tcattcataa 16980
tccaatatta ataatctttg atctctttca gaatgctatt cttaattggg tttttgcctc 17040
tgtgtgtttc tttttctttt ttgtttgagt gaaggccata tgttagaatt tggagaagag 17100
ttagcaggaa aacaaattcc tttattttct tctcctaagt tgaaatcaag aaaatgaccc 17160
ccattgattg ataaggaagt tgataaggaa cttgtactag atcattgaac tttaaaaaaa 17220
atatatttca tattcaaaat atactactat ttcgaatttg gatgggtaga gcagacaaaa 17280
tgaaatgtta tttcatcgca tttttgattg ataataaaca aacttaagtc atcaaaatta 17340
tacacaacat actcatttat gtttggctcg tatatttata actcctacat tttgagtact 17400
aaattatacc gtgatgaaac aattaatggt cattagtaac tagtaatact agtaccactt 17460
aaagtctgca cacgaaattt ttttaaaaaa ttatttttgt ttaatcatct actatcagag 17520
attattggct caactaatcc aaagtgacat cgtgtaaggt ttatttcctt cattataagc 17580
ttcgaatcca aaactctaat taagaataga gaaattaatc cattatgtca catagtaaaa 17640
aaaacaatca attgtcacac tacctatgct aagacaaatt aaaggtttca cactccttgc 17700
atttgatatc atctttagta aagttttttt tgggttgcaa actagtgaat cttgtgacaa 17760
attttattta tttcaagaaa atcatgttta ttattgtcga aaagtaaaca attaatttct 17820
caatgccact ttatggaaaa accattagca tgtgggtaaa ccaggtgctc tgccaattac 17880
attagaaata atacatgatc tggtatgatg catctcttta aatggtattc tttagattag 17940
taattagtta taagtaataa gatatccgat atttataatc ctcaatagga tacccttact 18000
ttagttttat ttaaaataat aataacttac ttaactcata tataaattta aatcaacttg 18060
acattatatt ttatttggaa gtcattcatg caaatggcca agaaccaaac aaataaatat 18120
aattttccta tatttctttt gaacctttta atatgtttaa tttaattttt cttcttttat 18180
ttcatggtca cgtgcactgc acacggaagc aagcccaagt aggcgtcagt ctttttcttt 18240
tcccttgaat tgttatatat attgacgaaa ataccctttt ctttatcgta attccgtcta 18300
tacaacaaaa ggctcacatg tcattaaaca tattctcaag gctaaataag gaataaaaaa 18360
caaatgtact tgctgcgttt tttttttctt cttatgaaat ttaaacagaa tattattaaa 18420
atttaatagg agtactggtt tttgccttca attggatttc ctatataata ctataatagg 18480
ccaaaagatt ttgtcttttc atttcccctc tctctctctt tcattctgaa aaaagaagtg 18540
ggattgtatt gtattttgat tataaattgt actcaaaatt gcttgaatta ctttgtacac 18600
aatcttgcaa ttcaactctt gccagtaagt tttcctaact atttttgtgt ttcttctaaa 18660
tgttactctt ttttcaggat tataaaccgt ttaatgccat gctcatccat aatatatttg 18720
atttgtatat ttattactcc tacttaatgt catatcattg attgaaatgc ctatcaattg 18780
cagtaaatta tttactactc tctttcacag tgatgaagta attaattatc attaataatt 18840
attactcctt tcgcctcaat ttaggtggca tcatttgaat tttaagagtc aaacaaattt 18900
tgtttcaatg caattttttc atatggattt taaataattt gattttatta gttgtcgtga 18960
cttatagtag tactttttat atagtttcta agtgtgtaaa ttttatttta aaaaagttaa 19020
taatttttat gttcaaattc acgatccaaa ttaagaagtt tgactctcga aattcaaact 19080
atgccatata aattgggaca taagaagtac tacttaaatg ttttacatga aaatgcaaaa 19140
aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaatag cactcaatta tcacactatc 19200
tatgttgtga caaagaattc acatcctttg taagttagca actgatctga actttataat 19260
aaaatatttt ttttgaatct agtgacaatt tttatttaat tttaagaaat tcaaattaat 19320
ttttgtcaga aagtaactaa ttgatttttt aatgccactt tacaagtaaa gtattagcgc 19380
gtgtgtaaac taaatgctct gccaatgaaa gtataaatat tccaatagta acaactttga 19440
tctctttgaa tggtattttg agagaagcat taattaatag tacttagtaa tttgttattt 19500
ataattcttg ataagatgca cttttattta ttcctcttta aaacaataaa taattacttt 19560
aactccgata taaatttgaa atcatcttga caatttgtct gtagtcaatc atacaaagta 19620
ctaaattaag gacccgttta actataaaaa aaattacttt tttggggatt tttttacttt 19680
tttcggattc aatgtttgat catgaaaatt ttaaatttca cttgaatctg aactttaaaa 19740
aatttcagaa atttaaaaaa ctccaaaaag ttatttttca aaaatttcag ttcaaatcac 19800
tcacaaaaaa ttataaaata gtttttttgt gtattcatat ccaaacataa ctctaatttt 19860
taaatactat ttttatttaa aaaaatattt tatttttttt ccggaatttc ataattgtta 19920
tgtccaatcg ctcactaaaa gccaaacaaa taattataat tatattttga tagaaaccaa 19980
ctttattttg aacttttaaa atgtttaggt ttttccccct cttatttctc ggtcacgtgc 20040
acggcacaca gaggaaagca gcagtaatcg tcagcgtttt tcctatttcc tcgtaacagt 20100
gacgagaaac agaatcccgt atccattttc ttatgcaaaa tgactaaaat acccttccta 20160
ttatcaaatt tcgttctgga tatcagattg tcattaaata gcttctcaag ggtaataatg 20220
aaataaaaaa caaatgtata tacagagtgc gtttctctct ttagagaaat tcaaacagaa 20280
aagtattaaa ggagttttga tttattcctt caatttgggt ttcctatatt taataggtca 20340
atatgcttct tgtcttttca tctggggttg tgttgtattg ataaaaaatt gtactgtcat 20400
tgctttttcc ctggggtagg ggaaggggtg cggggtatgg tggtgttgca gagttactct 20460
gaggtggggg agtgtatttt tccttgccat agaagctaaa gacctctaca tatagtcccc 20520
ttgtatctct cttacttttt cttcttcact gaacactcaa aactgtttga aatattctat 20580
acaccaatcc tgcaattcaa ctctagccag tgagttttct taactattta tgtgtttttt 20640
cccataaata tcactctttt atgcatttta ttcaagtggg tgtttttcat acagattact 20700
cttttatgca tatgtgattt acttgtgatg ttttnnnnnn nnnnnnnnnn nnnnnnnnnn 20760
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 20820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 20880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 20940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 21000
nnnnnnnnnn nnnnnnnngg gggggttgat tggtattctt ttcttgattt ttggtttgtc 21060
cttgtgtgtt tttttttaaa aaaaaatggt aaaaagggta tgcaggagtt ttgtgttttt 21120
tttttaatgt atgatcacct gattgtcatc tcctttagga gtttactgtt tcatcattgt 21180
tactcataga gttttcttgg attttttatg aagtgggtgt ttacatggtg ttaaatcttt 21240
aattatttgt gccttgtgaa atccttggtt tttcttagtg tttccttaaa atggtaaaaa 21300
gggtatgtaa gataaatagg cttctattat gtatgatcaa ctggttgtca ttttcttgta 21360
gatttttctg tttcatcttt gttacttggt tggtgtcctt atgtttattt ggcctgatgt 21420
taatgtagat aacaatcaat ggatccaact gaagttacag tctctgaaaa ccaacagctc 21480
tgcgctgtct ctctgccttt tgcaagaagg ttggcatttt acatttattt tctcttttaa 21540
tgtatcatgg agttagaaaa aaaaataaaa aaggaaggaa cttttgtaat gtgtgttttt 21600
tatgtatgat tttgttatgt agttatcagt tagaggcatt ggagacggca ttaaagcaga 21660
acactattgt ttatttggag actggttcgg gaaagaccct tatcgctatt atgcttctga 21720
gaagctatgc ttaccttctt cgaaagccgt ctccctacat agctgttttc ttggtcccga 21780
ctgttgtttt ggtggctcag gtactacttc tagcttccca agctagtgct taaacttcgt 21840
tatcttaatg tgtatatttt cactcctgtc tatagtttgt agaactgttt tattgagcat 21900
tggttttacc acattttgcg aattgttata ctgtttgagg agtacctctt tagtttgtgt 21960
tttttctaag ggctatggtt ttaggtgcat aactctctat ttgacttgtc ctaatgttgt 22020
tgatcttgcg attgataatt acaaagcaag gagatgctct cattatgcat actgacttga 22080
aagtgggcaa gtattgggga gaaatgggtg tcgattattg ggatgctgct acatggcaac 22140
aacaggtgga caatcatgag gtatgcgtga actatatttt atctttagtg ataaattatt 22200
aacacttgct tgagtaggca ttagatatgg ctacgatgtt ctcaaaaaga ttccattact 22260
gaagttactt aaatactaca attttttgtt gggacaaaaa tggaattgca tgtctacatg 22320
tctcctctat ttttcctgcc caaagccaat ggctatgaag tataagctaa tagtttctct 22380
ccaagggaat tcgcaaacaa agctgctttt ttttttgcct tgcgatcctt tttgttttgg 22440
catggctctt ggcgaatatt ttagatttga gtttcagcta tacagtcaaa cctctctata 22500
ataacctcgt ttgttccaac tatttttgga tgttatcgcg aattgctgtt atagagaaca 22560
gatattataa cataacatga aaattggttc cggaaaaagc ttggctttta atatagggat 22620
gctgttatag acaggtctta ctgtacatgc taggacttaa gttaggaact gtatatatat 22680
cacttggatg cccttatcaa aaaatatata cctggatgct tgataagtaa ttatcgtttc 22740
tgtctttcag gtgctggtaa tgacacccgc aatactactt gctgctttga ggcatagctt 22800
cttaaaaatt gaaatgatca aagttctaat atttgatgaa tgtcacaatg cacgagccaa 22860
acacccttat gcctgcataa tgaaggtacg ttgtttgtac tcatactcat cttctatcgg 22920
tatcacgctg gatctaaact tttgtgctta tcttcgggag agtgccctac ttaccatcat 22980
aaagaagaaa gaatggagca aagttatatc aacaacattt gatttctttg tcaatggata 23040
ttgattacta atgtgtactt atcgccactt cttcaacagt attttatttc agtacttcct 23100
gccgcttgag tgtatgtgtt gcatttcaca taccacttgt aaaaagttag ataaaaaaga 23160
gatttatgag aatttgggaa ttagataaaa aagagatttg agagaatacg ggaatacatg 23220
tcttatggct taattcttgt ataggcatac atttacctga tgtggcactc ttatgctcac 23280
gtcattgctt ttgtacatat gtgacttaag tctaactagt ccaaccaatc taactgcact 23340
taagaaaaga cccatgataa tcttgcttga gcatgccttt attacggtgc ttgaacaatt 23400
tttgtcttaa agggtggatt ttcttttcag gaattttatc atcgtcaatt aaccctcgaa 23460
agtgcacaac ttccgagaat attgggaatg actgcttccc ctataaagac taaaggttac 23520
tgacatttaa ttttatagct ttgaacatcc tttgagatgc ttttacctca taattcatac 23580
tcttagcaaa ctgtctttct gtggattgtc atattcatac ttttatttca ggttctagcg 23640
cggaatttac ttggaaaatg attcgtgacc tcgagaacct tatgaattcc aaggttctct 23700
ccaaatattt tccttttatc cattcacgtc atgcgatatg ttcttaaatg tagttcaaag 23760
gatagaagca tgttgtttcc ttttttaaag aaattgtttt ggtgatggca tcaacttgat 23820
ttttgcaaat gtatctttct gtaagccgtg tttattactg gactgtgcaa gcattaaact 23880
ttttgcttca gatacttgtc gtcagtacat tgcagagcat tgcacttgtt ttttgggtag 23940
catgtctttt taatgtatgc aagtagacag acacaagtag atatatattc agttcttctg 24000
attgtgttct gcctttgcaa atgaaggtat acacgtgtgt cagtgaatct gttttggccg 24060
agtatatccc attctcaact ccaaagctga agatatatca acatgtggat attccgtgca 24120
cattgtttgt tagtttagtt tctgacctga taaggttgaa agacaaggtg agcatcaatt 24180
ctttagccag tgggttctgc ctttctattt atagaatgtt catacatacc ttttgtcttt 24240
ctctctggat ttactccctt tatatcatat gttttttccc cttggaacct atatacaaca 24300
tcatttatca ttcagtttat gttggctctt cctttctcta tatacagtag tttgtgtgcg 24360
agctgaaaac gggtagtgca ctgagaaaat aatggaactt agaactaaac cttaatatat 24420
tcttgtaatg agattagaac aatcatgttg gcttgttcaa catatggggt ctacattttt 24480
gctctttcaa ttctggttgt gttttcttat cattgcagta tgaagattcg atttcaaaat 24540
cgagcctatc tgatttaagt gctggttctg caaaaaaaag attgtcaaaa ctatattcgt 24600
ccttcgtatt ttgtttgagt gagctgggtg tttggccggc tttcaaggta aatacgttcc 24660
ttgcttgtgc ataaaaaaat taatcagttt ggccttgatc attttcctaa catgaattcg 24720
ttttgaatca ggcagccgag ttcttgtcct ctgaagaaag cgacttcttt tcatggggag 24780
aattagatgt ttgtgctcaa acgattgtta gaaatttcag tttgggtgca tctaaggtct 24840
tctcggctcg cataccatct ggtatcataa ttagcaacat ccattttctt ttcctgagct 24900
gtaaatatgt ttttttgact tctttcttgt ttgttcgtgc gctctctctc cctccctgga 24960
aacataggtt ctcattggtc acttggtggt gatattcatg caaatgttga tgctggatat 25020
ttgacatcca aaattaatag tcttatagag tctcttcttg agtacaggtg agaggtctga 25080
ctagtaactc tatttgttaa aagcatcaat atcaattcaa tctattggat gttctataga 25140
ataaatggaa aaaaaagttg tcggatagat ttcttaggat ttgtggcaac gagagaatga 25200
catgcaattt tgtgttgacg gctttaaata tttttagaag cacaagatga gtgctaaaaa 25260
tttcaattct agagtcattg aactcgcaaa ccatctaact gtaatggagg gagcattatg 25320
ctgccaagtg actcccttac atgactgtac tttcatctat gcttttgaaa taacattgta 25380
catggtagtt taccgatggt ttatgctatt gcttttaatg atcacgtttt aatgttaaaa 25440
ctgtaatcct ctgcttcttg tctcgtctta tctttgatta aatatgatgc tggagtctat 25500
cactctattt gctccttgat tttgtgagat gtcttaaata atgcaactct cttgttggga 25560
aataggattt tctatttggt gattcactgg ctaacaatct ttttttgttg ttgacttttg 25620
tttccaatcc aatagagacc tgaaggattt gagatgcatc atatttgttg agagaatcat 25680
tacagctatt gttcttcggt ctttgttaaa tgagttgctt ccggaattaa gtggttggaa 25740
aactgagtac actgcaggac atagttctat gctgcagtca cagagcagaa atgttcaaaa 25800
taaaattgtt gaagaatttc gcaagggtgt ggtaagtccg gttttatttt tccccatctt 25860
tgtagataat ttctgaagat tgaaagtttc atttccatgc aaaacgctgc aggtcaacat 25920
tattgtagcg acttctattc ttgaagaggg tttggatgtt caaagttgca accttgtcat 25980
tcgatttgat ccctcagcaa ccgtttgtag ctttatacag tctcgtggtc gagctcgaat 26040
gcagaactca cactttatta tgatggttgg gaggtatgct tttccatcca ttccctcctc 26100
gcaaatacaa atattataac ttgagtataa ttgatatatg aatgttttaa agggttctat 26160
cattatatat tgttattggt ctatttttca cttaaaacat tctatttatg ctcctgtctg 26220
ttgtgcaact tttaaaaaca ttaaattact tcagctcttg attttgtgca attattattg 26280
ataaaatttg gaagatttaa ttataacaat ggactgatta tccttctatt tctggcttaa 26340
ttcctagcgg ggatgcttca actctcactc gcatgcaaaa ttatatgaaa agtggggaga 26400
tcatgcggca agaatcatta cgcaatgctt ctattccgtg ttcacctctt gatgatgaat 26460
tgcacaatga accttgctat aaagttgaaa caactggagc agttgtcacc ctcagttcta 26520
gcgtgtcatt gttatacttc tattgctcaa ggctaccttc ggatgggttt gtactgcata 26580
atccttgcta cgttctaatg atttggtatc tttgagtact tcaggtgtta aatgttgcat 26640
tattgactgc ccttcaatgt gattttaggt actataaacc cagtcctagg tgtgttattg 26700
aggaggaaac agaaacctgc accctacatc ttcccaaaaa ttgcccactg caaaaagtta 26760
ttagtgtgaa agggaatacc aaaatattga agcaacttgc ttgccttgaa gcttgtaaag 26820
aacttcatcg tgagggtgca ttgaccgaca atcttgttcc tgatatcgtg gaggaagaag 26880
ccatcatcaa agaattgggt aattctcgct tttggtaata ggttgttttt tttagaaaag 26940
agccaaatat atccctctac tttcatatat tgtctacatt taaccttcgt tatactattg 27000
ggccaaattt acccctacaa tcagcaaact ttgaaaatac ccctaaattt aaaagtttgc 27060
tgattgtagg ggtaaatttg gcccgatagt ataacggaga ttaaatgcta gacaatatta 27120
tgaaagtaga ggggtatatt tggtccttct tttttggact aaagttactt gccttctaac 27180
ccattatatt gcgcaggatg tcaaatctat actgatgaag aatcaaagta ctttccacca 27240
gaattggtta gtcattgtgc caatgataca gaagcagtgt actactgcta cgtagttgat 27300
ttgcaacatg actcttacag caattaccag cttcgtggga taatacttgc tgttaggaca 27360
aggctcaagt tagacgatga aagattgatt tttgacttgg atgttgataa tggaagcttg 27420
ctagttcaag taaattatag tggagttgtt aggcttacgt ctgaagaggt gactataatt 27480
tttatgactt ctatcctctc tttacttgtc acctgtaaaa aagtaggtaa tactttttat 27540
attctctctc cagattttac gatgtcagag gtttcaagtc agtctattca gaattcttct 27600
tgaccgcgat ctgagtaagc tgcaggacgc tttggctgca gttcaactgc ctgttggttc 27660
tgcagtttct gattatcttt tgcttccatc tttgggttca actcaaaacc ctcaaataaa 27720
ttgggaatgt gtgaattctg tgctgtttcc ttctcaagtt cttggggata agcatattga 27780
ttgttgttct acacaaggtc gcaaacgcag tgtgaacatc aaaactgggg tggtatgcag 27840
ctgcatgttg gagaactcat tggtctgtac gcctcataat ggctatgtgt actgcattac 27900
cggttttttg gataatttag attgcaactc attgctggaa cagagaactg gagaatccat 27960
tacctacaaa gaatactaca aaaagcggtt tgtacaatta actactaatt tcttggtgca 28020
gcttttcctt gtatgaactt ttggtttcaa aatattaact aaggtgcggt ttacaggcat 28080
gggatcaact tatgctttga aggagaacca cttcttaggg ggaaacgcct tttcaaagtg 28140
cacaattacc ttcaaagatg cagaagtcag aaggctaaag gttgaacaaa tgtttctctt 28200
tttattataa tgcagaactc aaaacttagt ttcatagttt aatggaaaat cacttattca 28260
attttcattt gacctccttg gccgactttg cagattcaac tgattcatct gttgaattgc 28320
cccctgaact ttgttccatc atcatgtcac ctatctctat ttctaccctt tatacctatt 28380
catatgttcc ttcggtcatg catcggattg agtcattggt tatggcctca aacttgaaaa 28440
ggatgcactc ggatcagtgc acgcaaaaca tttttattcc aaccgctaag gtatgtgctg 28500
ctatgatctc atcacagatt tagctccaat ttaatcagtc ttaaactctt aactttacac 28560
atagtctagg gcttgacttt acatcattgg actagctttt tctcgacttc cttgtgtttt 28620
agctgatttg tggtccttgt ttggttattt taggttctgg aggcaattac tacaaagaaa 28680
tgcgttgaaa agtttcattt ggaatcactt gagacacttg gagactcttt tctcaaatat 28740
gctgcgagta tacagctgtt caagacttat gaaaatcatc acgagggtct actcactgtt 28800
aagaaaaaca aaattatttc caatgctgca ttgtgcaagc ttggatgtgc tcgtaaaata 28860
ccggtaggta ttccttggtg atagtttagt tgggttttca ttatgagttt ggatagtatc 28920
aactccatgt ctatattaat ttttcttact tatttgcacg tgcactttaa tcaaagatcc 28980
tttgttgaat gttaattatt cctgcaacct aaaagttacg aactatcacg tatgaacatt 29040
cttttctact gtcccttgcc cacacaacta agtctagtgt ttgttataat gtaaattagt 29100
agttattggc cattgctgtt atctatattt gtaaaaattg tctacttttt gtcagtgcat 29160
caattggagt acgtttgtcg taggacatgt caattttgac actgtttttg gatccttgaa 29220
taagtaaata tgcctgtgta tacttaaaga tttcctatag ttgagtctta acattttatt 29280
tgtttaaaac ttctggattg cctgatgtgt gctatctcaa taaatacctt tctttacagg 29340
gatttattcg taatgagcca ttcgatctta aaggatggct cattcctggt gataattctc 29400
aagttcgcaa tttcgatgaa gaagtgctga tgccttctgt aaaaatgtat agtaggggaa 29460
ggcagaagat taaaagtaag agagtagctg atgttgttga agcactgata ggtgcctttc 29520
tcagctcagg tggtgaagta gcggctttgt catttatgaa atggcttggg atcgacattg 29580
attttgtagc tgcacctacg ctgaggcact tccccatgaa tgctgagaag ctagttaata 29640
ttcgatactt ggaatcactg ctagattaca agttccatga tccttctctg cttgttgaag 29700
ctctaactca cggatcttac atgctacctg agattccacg atgctatcag gttattctcg 29760
taaataaaga tttatccatc ttgatgttga ttgcattttt gcttcttgtg gttgctctat 29820
cattaaatcg tcaattagtt gggtctattt cttgttaacc cgaacatttc attgacctaa 29880
gcggctcgat agtacttagt gattcttcat aaaactgcta gtgacaagga acaaactgca 29940
ccgtttaatt caacaaccca gtaggatccc acaagtgggg tctaaggagg gtagagaggg 30000
tagagtgtac gcatacctta cccctacccg tggggggtag agaggctgtc accgtttaat 30060
tctttcaagc gattttttca tgattttatt tgaatcctgt cttgccgtct tatcttattc 30120
gaagttcaga tttccttttc ctgttctgtt gtaaggttga agttcttaca attgcgtgtg 30180
atctgaacca attgactcag aatatcttaa aaacaaaagc agtaatcgga cgttgtttcc 30240
aattgacttg tagtcttcca ttagcaatct cgtgaactta atgttatatg aacaatgaaa 30300
tatatcaagt ttgatgtttc ctaaatctag gtaactttct tgattcaact gttgatgatt 30360
tacctggcta tgtagcgctt ggaatttctt ggagatgcag tgctagatta tgctgtcaca 30420
gcgcatctct atttcaaata tccgggactg tctccaggac tcattactga tttgaggtct 30480
gcctccgtaa ataatgaatg ctacgctcag gctgctgtta aggctggcct acacaagcac 30540
attcttcatg cttcacaaga tctgcagaga cagatggtta atactgttct gaattttgag 30600
aaattggatc ccgtgtccac gttcggatgg gagtccgaaa ctacttttcc aaaggtattg 30660
catacttgcc tcatagttag aaataacact tcatctgaaa accataaatt ttagaaacga 30720
aaggaaaaag ttgacggaca gctcttcccg caatgaatta aacatctcct ttccatcatt 30780
ctcaacttca tctctattgt cgagagcaac ttaagatcaa tgtggattaa tagtactacc 30840
tccgtccaat tatgtggcac catttgagtg gtcacaaagc ttaagaaaga aaggaagact 30900
tttgaaattt gtggtctaaa acaagcatta gacatttgtg tggcagttaa atcatctcat 30960
taagtgtaaa aaggaaaata ataagttaaa ttgtttctaa atatagaaag acattctttt 31020
caggacagac taaaaaggaa agtgtacact gtaccacata aatgggagca gatggagtat 31080
ccaataatct aatctgattt tctattttag gtttattaac tcgtattcct ttctggttca 31140
atataggtgc ttggagatgt tattgagtct cttgccgggg caatctttgt tgattctggc 31200
ttcaacaaag atgttgtgtt tcagagcata cgaacacttc tggaaccgtt gattacaccg 31260
gatacagtaa agctccatcc aatcagagag ttaagtgaac tatgtgacca gaaaggttat 31320
ataaagaaga agaacgttgt ctctcgtgag aatggtgtgg cgtatattac agtagaggtt 31380
gaagcagatg gtgttagtca caagttcacg tgctcggaac gagacaaaaa aatggccgag 31440
aaggtggctt gcaaaaatgt actcaaattg ctgaaggaat gtgcatctga tgcttagctt 31500
tagtcgcttt tctgcaactt caggttacaa ttttcatatg ttttggtttc tgccctgttc 31560
cttttgtatt ctgctattat ttcaaagtgc gatgtttgtt ttgattgtca tttaaaattt 31620
attgcgatgt attattggat tcattgttat gtgacaatga agagtctcat tttatgaacc 31680
aatttgatgt tgggggatac tcgtgttatt tctttgtctc atgttgccct taattatttg 31740
ataatctgtt tttatcctta aacatgtttt tttaactcta tcattcagct tgtttggatg 31800
gttgtatgta tggttttata atgtattgta taatattgta ttgttttgat atataccgtg 31860
ttttgagttg ttattttatg atgtcatgca cctacaaatg aacttgtaat attataaaga 31920
aaaagtaagg catggggtat aaatattata taaaatggta gggtaaagaa taaaatatga 31980
ttatttaata ataaggaagg caagggcagc ccagtgtact aagctttcac tatgcgtgag 32040
ggtccggaga agagccagat cataaaaagt tatatcgtac gcagtcttac ccagcaaatt 32100
attttcacgg ctcgaacctg tgatcttttg gttacatagt ggcaacttta ctagttacgc 32160
caaggcccct tcaataacaa agaaggctga tgagacaaaa aagaaaagga aacgatgtgg 32220
ccacaccaaa ttggttgttc cataaagtgt cattttttcg ttgtttcaat gatagaattt 32280
aacgatatga tataataaaa tttaaataat aattaaaata aatattatat taaaataata 32340
atagatgata caatacaata tataacaacc atgtaaaaca agctgttacc taattgaatt 32400
gaattcatgg ctaaaccttt tgttagggta ttcgagtctc tgctgcatat acgtgcttat 32460
tatttttctg ttctataaac tcatcatttt aacaatacaa aagttaggct tttcttttgg 32520
gtagcattat tatatactca tttcatcctt ttccaaacca tacattatac atgtaaatat 32580
tataatttca aaggatatcc ttttttggat gctttcatta cttccttcca tatataatct 32640
aataaaagaa aattcacaaa ttatctgcgc aatggagaaa taaacacaaa taaatgtact 32700
tgaacctaaa atataacaaa tcattatttc taaaccttga tactcttaat ttatttcatt 32760
tttttttcta taacggaaaa actttcgagg gtcaatgacg tatgaatcga aacttgcgag 32820
ggtcaatgac gtatggatcg aaactcaatg atgactaatg tactctccct tctgtctttc 32880
tacacttata tattactttt gtttgtgtca gagtacgaac ttgtaacatg agcttaataa 32940
catatcacat gttgtgtttt tactactccg aagcttaatt tgtttcattg aagttcatta 33000
tagaaaaatg ctccttatca gatttttttt ttatttcacg acgcgaacta gactctctta 33060
tttagattaa agaaattcta tccatcctat cataacacac attaatattt gcttcatttt 33120
attgaaaaag ttgtagaatt ctttgactat aaattggtaa acgacacttg tatttggtga 33180
ttattcgttg acaatctaga agataatgat agttatctat ttatttctcg tggtctttta 33240
taggttgctt ctgggacttt aatttctttg aaatgtgtta tgcttctttc gacgtgtctc 33300
tttttcttca aaaatctatg ctattcaaat tctttaaaat ccaaaaggat ttaaaaagaa 33360
tgaataaaat ttctttttct tcaaaatcta tacgattcaa attatttttt attttaaaaa 33420
agaaaaatta atactattag gggccatttg gttggtgaca taaggaattt caatttcggg 33480
ataaaatgcg ggtttatttt atcccgcatt tggaaatggg tagttattag tttcaataac 33540
cattttgtac taaaatggtg ggattaacta ttccaaatat aaagtgggat agctaacccc 33600
ttaaggaatg tagagaaatg ttaaatttct tgtcattaat atttaggaaa taataagtat 33660
tctgcaacgt gaattctgat taaacttttt gatgaatttc agatatttat ttaatggtta 33720
aaaacagata taaattcgaa cttcataata ataggttcac aaatgcaagt cataattcct 33780
ggagaaaagg caaaacactt gtcattatta tagatatacg aggtgcattc tatttatcca 33840
gaaaatggcc ccattttcct gttcttttcc accttgtttc ttacgtatac tccatttttc 33900
acgttgttta tatatttctt gccaaagtaa aacttgatat aacaataaat tttgtcaaca 33960
aactttgaca attccctcaa tttattagct tttcctttat ctggtacacg tgtgactata 34020
aatggtcttt gtttttatta atgatatgat atatattgct aaaatgagtt cgtacaatca 34080
cccaagacgg taacggaata aatataattt ttttaatcct taagtcttaa atttcgattt 34140
aagatatgaa ataaagaaca cttcctcgtt taatgagcat gttgagaatc caaattaggc 34200
gtacatattt acccacccta agtttttaca tctaattaaa taattaacct taaaaattaa 34260
taaatcaaaa tgaaagtaca tatatatcac ttgacaatga ttaggtatta aaaagtgctt 34320
cctccatctc tgatcatttg tcattatttt tataaaaata attatatcaa attatttatt 34380
attttaaaag ttcatgacaa aattaatttc cttttatttt atcattaata gtaattgttc 34440
atgaagacgg agataccaca taaataaagt aaatattcaa tacagagaga ttatatatct 34500
taggacataa atatagataa aatagttcaa aactcctaat agtatttttt tcaagaggca 34560
tgtaaaagaa aaatacgaca gataatttga gatgaaaagc atatatgtct cactttcatt 34620
gatttgatgt aaagcatcct aataaatgat ttgtctagaa tgagaacaat taagggttcg 34680
tttgatagaa gggataagag ataattaatc tcgagattaa atttgagatg actttaactc 34740
acgttttatt agaataaaat cgtgatataa ataatctcgg gattagttat cctaggatcg 34800
tagtattttt tttaaaatct ccatgggagg gtgtgataac taatctcgaa ataattaatc 34860
acgagataac ttgtttctta accaaacaac catatggaaa gaagttatct taggttatcc 34920
cgagattaat tatccccaaa ttagttattc tacctttcta tgaaaataaa ataacagtac 34980
aatcccgaaa taacttttaa tctcgaaatt aattatattt taattttctc tcaatcaaac 35040
atgatataaa cttttcgaat taattattac ttatggttca taccaaacca gcctaaatgt 35100
gtacgttaaa attcagctga ctagaatagt agtaatacaa ttaaaatggt ccccacaccc 35160
ttagattttc cattattaca catatctaca cacttctttc aatcaaatac cagtaggtcc 35220
accaaacttt tctacaaata tataaaaagc ccccctcccc tgccacgaac cattcacttc 35280
aactaccacc acctccacct aactaaccgt cgttgttcgg agctccgact gagcatcaaa 35340
tgttcaaaca atactgctgt tgtctctttc cgggtcggag ctccgacttc gtcaatgatg 35400
ttgttgctga tagggaccct gtattgttgg tttcgggtct tgccgggtcc attctccatt 35460
caaagagtaa gaaactgggc ggttttgaaa cccgggtttg agtccgactt ctccttgctg 35520
aacttgagtt taagaataag ttatggtcca tttacaatcc taaaacaggt agtaataaca 35580
tttctttagt attatttggc ggaattatca atgaaaatgc ttttattgaa tacgcaatga 35640
ggtcatttat taggtgacta catgttaatc tcttgataag tagttataaa ttagtaaaaa 35700
ggcagcccgc tatgcgcgcc agacacaagg gtctgtttcc acggctcgaa cccgtaacct 35760
cctggtcata tgtcagcaac ttagttatta attagtatac ggtaaaaatg ttaaataatt 35820
gctatcacag gttaaagttt attgatagtg ttaaggaatt tttacactgc tagtgccgtt 35880
tagtttaaat gggaactaga gtttaagtta tatgcactta cggagtaagc attttttttt 35940
ttacataatc aggttactta ttaggtaatt acatgtagat ctattgacta agtaagcttt 36000
tttcttgtaa tattcagggt atacagagtc attggatgac aacacagaga tagtagtgcc 36060
tcaagatgat tatgggctat atgcaattga tattttggat ccttctatgg tatgtttttg 36120
catcatcaag tggtcacaag tgtatgtata ggtcctatgt gcattagtat catgtttctt 36180
caataatttt gttgtttgta gttttgctag gtacaaattt ttatggggag gtgatgtaat 36240
cagtaatctt gaaaagtcat agcaccttta tatatataga agctaataat acctgagttt 36300
agaagctaaa tagttacttg agggtatctt ttttaaaaaa taattacttg agtataagta 36360
cacttaagtg gtaggtaaaa tgttttgttc cgaaggaaaa aaaaagtgat aagtggaaca 36420
tgaaatatgt gtttcatcta tcaaaaagat attaccagtt agtttcatct attatactct 36480
acatgtcctg cgaaaaataa atgtatgatt cgtcttttgt ttcttttcct ttcctgaagt 36540
acttttctct aatgagatca tgatctcttc taattgtgtt tgatttccag atggtgaagt 36600
gtgtacactt gaccggtgta taccattttc atgatatgat tgatatgctg gtcaaatgtg 36660
gatataaaaa aggaaccaca ttgttcggtt ttggttacga cttccgccaa agcaataggt 36720
attattttaa ccggtgaaat ttccactgcc cttatgccat atcgcattgt attatagctt 36780
attatttgaa aagccagttg attgtgatga tagcaaacag gaacagctca gttctattta 36840
ggcttatttg attcttctgg tgaaactatt ttcgcactta gggatttggt tagcatatgg 36900
ttgcaggatt gacaaggcaa tgaatgacct gaaagcaaag ctagagacag cttataaagc 36960
ttctggggga agaaaagtcg atattatttc gcattccatg ggtggattgt taatcaaatg 37020
tttcatttct ctttatagtg atgtaagtcc aattgcttta gactcattca tttgcaaatc 37080
atctatgcta tttaatcaag ctatattaat caaaagaaga taaagtcgtg tcctaagtgg 37140
agagaacaag ggattggtct gttgttcccg ttggtcaact atgtgtctcc tatttaagat 37200
aatgtattcc tatttgttct gctcatgtat cttttctgtt ttgcttttct ttctccttaa 37260
ttcctgccta gcttcttgat ttagatttgt cactcttcct tgagtggcat cgctaaatgc 37320
aaacagttgc ctttcaggta ttttccaagt atgtgaataa gtggattacc attgccactc 37380
cttttcaagg taactttgct ttctctcttt gcagcttttt gcagatgatg tcttttttga 37440
attgctagga tacgagctaa gatatcctta tcaatcaggg gatgcataga taatacagat 37500
agtgagataa atttgattgt catatttgag cacctccacc ttccaaaaaa gaaaaaaaga 37560
agaagtgtgt aactagagaa ggtcatggaa gcatcagaaa cttagctttt ggtgggggag 37620
gtaccaatta caaaagtata aggaagaacc aataactaat tgaaaaataa ttgcaaagaa 37680
tacaaccaaa tccatagctt ccaaatcttt atttatatat tcagtaatta aaagaagtga 37740
gaaaaaagaa gatgcacaac ttcttttgaa gattactcaa aatgtatgcc aataagataa 37800
tttctgcaaa aaaaatggta atcagtatat tttaagtagc aggtcctgac taaaaggaat 37860
acgcatagag cggaatatta tatagaattg tataaaatct gagttgacca tttgctatta 37920
tagtcctgct tagtcgaaag accaggcgaa cagtataaag ttctgaaata taggaagagg 37980
aggaggaaat aggaagagtg ttatataaaa gttattataa accagtaatt tcctaaagta 38040
gaaatactga atctttaaga atcattgtta aaggaaaaat tgtttgcaaa tagtaatgct 38100
tataattgga gggaggggaa ggttgtaact tttttcttcc agatttctag tgaaacgtat 38160
taggattcac cttctatttg tagggtccca atgtatgagt ggcgagggag agtccatggt 38220
cctgccagcg ctcctgccct accgcactaa aaagaagaaa gaaaaagaac ctaattgtgc 38280
ccccccccnn nnnnnnnnnn nnnncgaggg tgggggggtg gaggtgggag atggagcttc 38340
atgaagaaac aatattcctg tgaaattggt ttcgaaagag tctttaccat ggctagagtt 38400
catgctcctt aagaaatgcc cctggacctc gaggctgcta gttacaagtg tgcagagtac 38460
tgattgttca tctcttgtaa ataggtgcac ctggatgcat taacgattct ctcttaactg 38520
gagtgcagtt cgttgatgga tttgaaagca actttttcgt gtcaaggtgg acaatgcatc 38580
aattggtaag ctctcttggt caaggacttt tgcaagagcc ccgttaatag catatgtagg 38640
aaacaaagct tcattttatt aatagctcca tatctgttac ttggctggca aatatgcctt 38700
gatgatgaat ttaatctacg tgcttcctta tttactgaag attagactgt ttcaacaaat 38760
taagctagta aatagagatt acgctcgagt atgtctaact tcatatgctc aattttcatt 38820
tttatattat ttaatcatat cttcaatggc cctaggtagt tagtagatgt atcagaagta 38880
agactttccg aaactgtatg tttgaagtgt attgataggc tttgccaaaa gactttgaac 38940
cttacttttt catctcttaa accatggtat ctacaaaatt gagttaaact ggaaatgtca 39000
tttgattgcg ggacgactgt tcgttcacct ggtagttctt gtattttatt ttttgtgata 39060
ctcaatggat tcactgatac ggtctccatc aatactgcaa ataattgttt gttcgtcaat 39120
cttgtccttt ttaatctttt gcaagttggt tgagtgccca tcaatctacg agatgttgcc 39180
caatcccgac ttcaagtggg caaagcaacc tgagattttg gtgtggagga aaaaatctaa 39240
ggagggggag acagtggttg aactagaatg ttatggcgct agtacaagtg tgactctctt 39300
tcaagaagca ttgaagagta atgaggtata tctccaagct atctttagcc actagaattt 39360
ttaactttat attacaagtt cttaagtttc atgcttctgc atctctccaa ctcgccaatt 39420
agctattaaa atgagaaggc ttgtttgctt gctgagaaag catttcgatc tcatgcatgt 39480
ctgaactagt caaagcttaa agtaatgagg ctttggtaaa atatgtgtaa catttttcca 39540
gaggagcctc cccagtgatg ctgaaaaatg tcacttcgac caattgtatt tttaagtgga 39600
taaatttaat ccaaccaaaa gcaagggtgc aactgctgta tgctcacttt atttataaca 39660
agccagaaca tgatgttcat atctgtgctg tttgtataac acatcaaatg accatgacct 39720
tttccttatc ttccttctat caaaaattca ctgagctcac ttttatgaga caaaggctag 39780
cagggcttag aggttagatt aaacttgact tacatttgtc ttatttgtca tgttagaggg 39840
caagatgaaa attgttctat tcagttctct gtaaaacatt tttttttttt tgcaccaatt 39900
taaagaatca taacatcgtc tatgcagttg aaattttaga acttgtgggt gatgtacctc 39960
ttcggatgtg tagcaactat tgaaggatgg ccaaaaataa atcgtatgtc tcatacataa 40020
gaatataaga tagagggaga atttgttatt attattggtt ttgcatgata ttgcttacaa 40080
cctgcttctc ttatgcatct ttctatgact agaagccagt gtttgtagca agtgattttt 40140
tttatgcccc gaattgcagc tcaacttaaa tgggaaaaca gtggctctac ctttcaactt 40200
atcaattctt gattgggcag ctagtactcg caaaatttta aacactgctc aattaccgca 40260
aggaattcct ttttatagca tctacgggac atcttttgat acaccttttg atgtttggta 40320
tgtaacttac atcttatcat acaacaagac aaggtagttc ataactggtt cgtttttgtc 40380
tgaggttatg cactattcaa tgtgtacgtg tttcttttgt agttacggtt caaaggcttc 40440
accaattgag gacctaacga atgtctgcca tacaatggta actaactttt tctttttcct 40500
tgcaagtaca agtgatatta tgacattcta actctttttt taaaaaaaac tggtaacttt 40560
tatgacattc taattcttct gcattttttt tctgggtttg tggttttatt atcagggaag 40620
attcttttgc cttgtgttct tattggtgta ggtagaaacc ttgtgtctcc aaaaaaggtt 40680
ttagagttag tagtgatata acctgtgggg ttaaggctcc aaatagcttg gctccccttc 40740
tggctaaagt tcaactcaga cttaaggatt tcttgggtaa tgttatctga gatataaagc 40800
cgttatgatc aactctttaa ctaagttatt agtatgatat attagactgg tttatagtca 40860
gcttaactaa ggtcgcattc ctgactagtt attccaccaa atggagctaa gaggcgggtt 40920
aatttctggc aaatatgata tgaatctcgt gtttgttttc tataagtttt ctccaggtat 40980
ggaatttagt caattgacca ttggttaatc ttcttgtaaa ctttgatcct tatcttgtgt 41040
ctggtttcga cgagtctgct ctccaggtat ggaattgact atttcccaaa acttggatga 41100
gtcttagata gcacttccct tttgtgaatg accccataca gaatctttcc ttcaaaggtt 41160
tcaccaaatt ttacttccca aagccattca aatatcctcc aaagatataa atcccacagc 41220
ttgagggatg atagtacgtt ttgttccaga agcatcagta atgcatgtga tttttgttgt 41280
ggtcacttgg gggaatttat aaacgacctt ttcaatctta tttagggtgc tttaatggag 41340
tgggtaacga ctaaggtgtg aagtgtgcgt ggggatgaaa ttcgttctgt atttagagat 41400
ttacatgtct ttattgttat ataatgcttc ctgaagcttt tctacttact attacctatt 41460
cctgtttgtg atatagccgc aatactccta cgtggacggt gatggaactg ttccagctga 41520
atcagcaaag gtgttattct tcacttctct actttgtttc ttactcttct tatatattat 41580
aaagactaat ggtatcttgg cacgtataag taagaatctg attttaatga gtaagaaaaa 41640
gaaaaacaga tagcagtatt aattttctgc ggtgacatca gttttagttt tcctacagga 41700
aaacctggat attaagtaaa atgacagctt gtctatacta tggtcgactt cgtgactatg 41760
aaacattgga taggtgcttg acaaatgctc agtatcttgg ttgattgttg accctctgct 41820
gataactttg caggctgata attttgaagc agtggagaga gtaggagttc aaggtggtca 41880
cagggaacta ctaagagatg agaaagtttt ccagcttctc aagaagtggc ttggcgtcac 41940
cgataaaaag aaggcacatt ccaggtcctc cagggtagtg gacctttatc caggtcaaaa 42000
gttgtaaaca tttgttctgc tcattcttag agcacgtttc tgatctctct ctcgctttat 42060
tagtcgtagt tataagtata tacgcgtgta cattcttcga gaatgttgaa gttagcttct 42120
acatgaatca tcgtatgtta gtgtcaatat gtattaggca ctccaggata ttagaaaatc 42180
agtccaaaac ttgctgtaag aacaatgttt atcgtgtata tacacgagaa tccagaggtt 42240
ttatcttttg ttttctttac tcctttttag ctattcttga tttgtagaat taagaaatgt 42300
tttcttggtt ttacctatag ttttgtagag ttaaaaaatg taaaatcttg aatgatcttg 42360
ctttaatctt ccttgttgca gttatgtcca ggttcaaatt cttgttcatt tattcatttc 42420
tttggaggtg ctgaaggcat ttcgttactt tttcttacct ctaatagtaa tctactcagc 42480
aattcattta taccaaacag tttaaagaca agaactgttc tttattgaaa tcatccttat 42540
caatctcatc taaattgcta tatctttgga cagactaatt catagccaag taatatttct 42600
acaattttaa ataaatacaa aatcaaaata gaatactcaa tcatgaataa ataccggcaa 42660
aataccctct cctatgtata taatgtaaac aaaaaagtct atgtagctaa aatagtagta 42720
aataaataaa taaaaagaaa aaaagaaagg agcaatagca tatgtctaac ttattatttg 42780
ttctttttca ttgttttgtt tcccatacta gtgcattaca gagggtatct agctatctat 42840
atttaccagt tagtggaata tacatataac attttgtaaa tatattccta tcattcaaca 42900
aaccttatta atttaccatg gttaagtgag aattgttaac aagatgtgta ttgattaatt 42960
ataatttaat gataatagta tacgtgaaga cataatatta tattttcatt gtattggtac 43020
caacactggt gtcacaccct tttttactcc aaaagatata agttatggat cgtggattga 43080
agagtttttt caattaaagt gacaaacttg agtagggatt attttattta cagagtcgtc 43140
gcttggaatt ggttttgggt gttccaagtc accttttata tgaatactta gtcagaggaa 43200
gatttgactc tattattatt ggtctgcgaa aataaagtct gggtaaagaa ttctgttgac 43260
aggggaaaag gtgtaaggca ttccccgagt cccgtgattc tagcacggtc gctttattga 43320
cttaaatttg gcttgaatta attttggatt aactgtgctt tatttggttt tcatgttttg 43380
cctatatctg tttttattgt tgatgatttt attaatctca aactaggacg agtattcccg 43440
atcctagctt acactaacca agacgagtgc ccccgacctt agtttgtgcg ttgtacctaa 43500
aattggagcc tactcgaagt taattaaata gcaaactttt aattgatcga aagaattgga 43560
acaagacgta ttctcatgac cttgccattt tatttatatc tttatttcga agcgtgtctt 43620
ctcgacatcg gttaagacaa aattaattat ggaagaggtt cgtgcatcct tattgtgaaa 43680
aaaataaact tctttgtagc tagaagataa tgagttcgca tatggataat taattgatgt 43740
tggaccaatt tataacctta cattaaacaa atgatgaaac aagtataaac taagtattta 43800
agagagttat ccatattcgt gcctaaaatt tgcctaacgc ttaaattaaa ttattagtga 43860
ctaagttatt aaactgttag ttaaacttta agagaaggtt attcgactaa cttagcgtga 43920
agattttggg acagcttagg atatagtaat tattgattat agaagatgga cctaaaagca 43980
tcctagtaat atttggatta aaacagtaag gcaagaaaaa ggcatgtatg tgattattta 44040
aagccaccca tggcataatt ttgaannnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 44100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 44160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnntatata tatccccaca 44220
aaaaactagt caaaataatt tattatacgc tacttacaag tacaggtaac ttgagtcgaa 44280
aagaataaat tttttttaca tggaggaaca aataggatga ctaacttgca atttgaaatt 44340
taaacttgct actatgaagg agaatgaagt tctctttgta tttgtaaaaa aaattaaata 44400
ttcgttgttt tgggagatat tagcagacta acgaacaaga taaaaaattg ggaaagatca 44460
taaattaggg ctttaatcaa taaaaaggtc ttgacttcta aatttgatat atttcagttc 44520
atttttaaaa cttttgagta attacaagct gacttttgag aatttgggta ttatatgaag 44580
gacttattca acaaattttg ttttaatttg aaaaagtctc tggggcttac ggctcaatac 44640
aaaaatgcgc ctcaaacacc cgaacgtacg ccctgaacgc ccgtgcgtat gccccgaacg 44700
gctaggcgta cgcctcttga gactttcacc ccagatcatc gcctcagagc gtttttggtg 44760
gggttcgccc cggaaacgtc ttttaaaaca ctgattttga ccaatgaaac gaaatagtag 44820
atattttgga gcccaattcc ctttattttt gtatccaaca cttatatccc taacatgcta 44880
ctttctttta taccttcgaa taactgaaac tttgttacca atcttaacaa gaagaaatgc 44940
taacatatca gttgtagaag gcatataact gaaccaaact aaagatgcta tcatgaatgt 45000
atataaatgt ttcaatggaa aactacataa ggaagtcaaa acagagggtc atgtaaccta 45060
aactcaaaca tggaacatga actaacaaag taactttaat tactaaagta aaagtgtgaa 45120
tgaaactttt ttgatgaaac tttacactac ccagttcgag atagacttag tagaatagag 45180
tttcaaccac atatatgtaa agaagaactg acaatttagt taacttctaa cagatttaca 45240
tgatgataac actaacattg atagacttag tagaatagag tttcaaccac atatatgtaa 45300
agaagaactg acaatttagc taacttctaa cagatttaca tgatgataac actaacattg 45360
atagacttag tagaatagag tttcaaccac atatatgtaa agaagaactg acaatttagc 45420
taacttctaa cagatttaca tgatgataac actaatataa cattcatctt taaacgaagt 45480
cagatctaac atgtttcaac agccaaacca aggtcaaatc ctttttattc tcatcaagaa 45540
tctgcaatat aggaatttga aagttaccta gtttgtagaa taataaaata cagcagtgca 45600
gcaacagaaa ttcagcagca aagacagttg aaatagcaat aggaacaaca gtgaaatcag 45660
cagcgttaaa gcaacccaga aatcttagta aaaccagtga tttttcaaga gaagaaactc 45720
agaatcaaac tctaagtctt ttctattttt ctgaaagatt atgcactcca agactcactc 45780
acaatttcag cttactaaag gaagcttcaa ctgaattttt tcgcttaaag ttgtgttctt 45840
tttccggtga gtagagatat gtattctaag tgtgatagag tgtgtctgta aagtgagaaa 45900
agagcagctt taagtaggca aagaaagtca cttttcagac agattttggt tcaccaaaag 45960
tctgtccaaa aagactcact ttatgtgcca aaacactgcc caagggttgt ccaaaaggtg 46020
aacggacagc ctgaaaacta gttactagta ccctaaatca ttatcaaacc aatctaacct 46080
tcagatttta tcaacatcaa taccacccta tttgtaacaa accaaaaaca agaaaccagt 46140
cactaaaact gattaaattg aactattaat caacaagaga tttcaaaact taataactaa 46200
aaccaaagca agcagaacac atgttaacaa tgaagcaact agtgaagtcg attaagttaa 46260
atgacaacgg aatcaaaaac tagattcaat gttaaactaa aacgaaaact accagaattg 46320
aactaaaaca aaagcactaa caccaaatgc aaaaatataa aattaggggc ggggagaaag 46380
ggaattgatt ttacccgatg tcgaacaccg gggcagtggt ggtacggtgg aagtcgtgcg 46440
gcaatggtga gggtttgaca gtggttcggc tagagagaga ttctattgtc gatcttcata 46500
gaaaccaaaa ctctgatgaa tcggagacta gtgttaggcc ccgtaaatgt tacctagatc 46560
ccggggtttc atgatgccga ggtaggctaa tgtgttcaaa atttttagaa aacgagtaat 46620
ggtacagaat ttttgggttg tacaatgcat agtggaatga gtagaagaaa ttgcagaaaa 46680
tgatgattct gtggttcatt atgttatagc ggatctgttc tgctaaccac gaaatgacca 46740
cataatgaac cagaaataat tcaaattttg aaaactattt ttgctggcaa cataatgatt 46800
ctactggccg tataatgatt atgctatcat gaaattgcat cgcggaatgg actagactca 46860
acccagaatt taaaaattat tttgtggcca ttatgccagc tgcatgatca ttctgctatc 46920
gcagaattgc atcgccgaat tgacatatca ttttgtggat attctgctgc ccacataacg 46980
atttcgctgc ccacataaca attctgctac cacataattg caccacatga ttgacttggg 47040
gggtcatttt tggaaatttt cttatccggt cctattttga tacaaggcct cattttacta 47100
gataaaatct gatattttag agagaggaga gagttgttcc agagagagaa agaagggaac 47160
caacatcttc atgcttcaaa ttctcgctca atcattggag attcatggga gaaatccaca 47220
agatcttcat ctaataggta aggttctact ccctaaccct aaatttcgaa atttggacta 47280
aaagtagtca tcagaagtat gattcttagg tgtgggaatt gctctttgta catgaatgta 47340
accataaggg tggtagggag gttattgaac taaaaggagt aaactcttgg tattgaattg 47400
gttatgggtg aaggaaatct tgtagaagaa ccttgtagtc aaatttgcac acctagtgtg 47460
tgatgaccca aaaggtcatc ttatatttta gacctcgaat ctgcactctt aagtcttaaa 47520
aatcttatat ttatcctcct cgattttcat gagcagtctg ggcatgtttc cggaaagctt 47580
tatgttgaaa attgatgaaa acaagaattt atgccttaaa aagttgattt tatttgattt 47640
cagtcaatat ttttggtaaa cgggtccaga tccatatttt gacagtcccg gtgggtccgt 47700
atcgaattat gagatttggg catataccca gaatcaaatt tcgaggtcca tagcccgaaa 47760
aataaatttt tgactaaaat tgaatttcag aaaattaatg attttaaagt atatgcttaa 47820
tgcttgattt tgatggtatc atgcccgtat tttggtttcg gattccggta caggtccgtt 47880
gtaatatttg aactatgtct ttgaaatttg gtaagaaacg gagtttaaat gacgtaattc 47940
ggaccttcgg ttgagaaaat agtaacttta agtgttcttc agaatttcat tgattttgat 48000
gctaaatctg cagtttaagg tgttattttg gcgatttgat tgcacgagca agtccgtatg 48060
atgttgttag acttgtgcgc atgtttggtt tggagtctcg agggctcggg tgagttttgg 48120
ataggttacg gggtgatttg tacttagaaa atctgagatt tttgctgcag cagctattct 48180
tttgtgccct tcttcgcgtt cgcgtaggta gtgtcgcgaa cgcgaaaggt aaaatggggg 48240
caggggaatt ttcttcttcg cgaacgcaaa gcattggggg tggtaccctt cgcgaacgcg 48300
atcagtctcc cgcgaacgcg atagtttaag gggcctgggg gagggggggt catgttcttc 48360
tacgcgaaca cgaccattgg gtcgcgaacg tgaaggcttg gagggagatg ccttacacga 48420
acgcatagaa agactcgcga actcgaaggc cttaggctgt tgtgtatcgc gatcgcgaca 48480
ggcctatcgc gaatgcgatg aaggcatgtc cagtgtttta aaacagactt caaagacggg 48540
atttgttcaa aatttcacat tttcttcact tgaactcaac cttgggcgat ttttgaagtg 48600
gaaattcaac accaaatcat aggttcgtgt tcttaaactc attcctttca atttccatca 48660
acacccacta gatttctagg cctaaatctt gttctttaag ggtagaaatt agggatttta 48720
ggagaattag ggattttgta aatttgggaa tttagacccc gatttggggt tggatttcgg 48780
aactaatgac atattcgggc tcgggggtga ataggtaaac ggagtttggt ccgaacctcg 48840
agtttggacc aagcgggccc ggggtcagtt ttttactttt ttgagaaaat ttggaaaata 48900
tgtaattatt cattaaagtt gattccttta gcgataattg atggtattaa gctatttgtg 48960
actagatacg agtgagttgg aggtgaattc taaggaaaaa gcggtacttg agcagtgagt 49020
ggcctgcgaa tcgaggtaag tgtcgtgtct aactttggct tgagggaata ggtattatgt 49080
gtttatttgc tacgtgtttg gttgttaaat acgatgtata ggtgaggtga caagcatcta 49140
tgcgtcgttg tcgagacata gcatgcgagt gaaattctat ttaattctat tttgaagcct 49200
taaattctac tatccatgct tagcgggtta tttgaaatgt tgagtgactt atatctggtt 49260
tcactgagat ttggtaactt tcgaatatta attcaaggtt gaggttacat tgtgctattg 49320
attatggata aaatactgat ttctttgtga tactcctatc tatccgttgt tattgattct 49380
gtgatttgtg aggaggagtg taaagcacga agggtgatgt cgtgcatgca ttatttatat 49440
tgtgaggaag agtgtaaagc acgaagggta atatcgtgtc gtgatatgtg agtgttaatg 49500
cacgaagggt gatatcttgc catgatttgt gagtgataaa gtacgaaggg tgatgtcgtg 49560
catattatga gaggtttaat gcacgaaggg tgatgccatg ccgttctatt tatttatttg 49620
gtgaggttga gagtaaaagc gcgaagggtg atgctatgca gttttccttt gctgttttat 49680
ttactcaatt cgtttaaaga ttttcggttt aattctgtct tttcattatt ctccctcttt 49740
atattgtatt cccccactgt atgttccctt tccattattt ctgcgttact tctttattta 49800
ctgttgttgc cactggcatg attatactgt ttaggttata tgtgggtgtc ttgtcctagc 49860
ctcgtcacta ctttgctgag gttaggctcg acacttacca gtacatgggg tcggttatac 49920
tgatgatgca ctctgcactt tctgtgcaga ttttggtatc ggcttaggtt gatcgagatt 49980
ttactattgg tccgctgtcc ggagactcaa ggtagatctg tcggtgttca cagatcttga 50040
aatccccgtc tatcttttat gtcctactgt tttctttcat tcagacagtt gtatttcttt 50100
cagactatta cttatagtaa attctagaat gctcgtgaat tgtgactcca gatccgggtg 50160
gtagtaatta atataatttt ataatattct gcacttatta tatttcatct tagttaatta 50220
ttgttattta ctgaatggaa ataaggaatt ggtttaatga ttctctaacg ttggcttacc 50280
tagcaagtaa aatgttaggc accatgacgg tcccgtcggt gaaaaatttc cggtcgtgac 50340
agttggtatc agaacactag gttgcctata tctcacgatt cacgagcaag cttagtagag 50400
tctggaggat tggtacggag acgtctgtgc ttatcttcca gagactatga agtttaggaa 50460
caagtttcac ttctattctt ctctgtcgtg caattttgct ttctcaatac tgattgaact 50520
cttctactct tattctctcg cagatggcga gaacacgtac cgcttcctca gctgatcagc 50580
agccagagcc tccagtggca cctcctacgc ggggcagagg tcgaggctgt gccagaggcc 50640
gaggcagtgg cagggctcag cctaaagccc gagcagcagc cccagcaatg gagcctcata 50700
tagagcttga cgaggaggtt ccagcccaga ctgttcctac cggaccagct taggttccgg 50760
aggggttcat tgccacccca gtaattcagg acgttttggt ccgtttggtg ggccttatgg 50820
agagtgtggc ccaggttggc gcatttccca tggcaccagc agtttcttag gctggaggag 50880
gagcccagac tcccaccact cccgttccga agcagatagc tccccagaat caggctccag 50940
tagctcagcc agtcggatta gttcagccgg ttattgcggc acaggtcgga gatgggccag 51000
ctatgtcttc tgaggcttta tggagattgg acaggtttat caacctgttc acttcagtgg 51060
tgctccttca gagaatcccc aggagtatct tgacagctat catgaggttc tacggaacat 51120
gagtatagtg gagaccaact ataccttgac agctgttgcg tctatatacg cgagaatcca 51180
gaggttttat cttttgtttt ctttactcct tttttgctat tcttgatttt tagaattaag 51240
aaatgttttc ttggttttac ctatagtttt gtagaattaa aaaatgtaaa atcttgaatg 51300
atcttgcttt aatcttcgtt gttgcagtta tgtccaggct cacattcttg ttcatttatt 51360
catttctttg gaggtgctga aggcatttcg ttactttttc ttacctctaa tagtaatctg 51420
ctcagcaatt catttaatac caaacagttt aaagacgaac tgttctttat tgaaatcatc 51480
cttatcaatc tcatctaaat tgctatatct ttggacagac taattcatag ccaagtcata 51540
tttctataat tttaaataaa tacaaaatta aaatagaata ctcaaccatg aataaatact 51600
ggcaaatacc ctctcctttg tatataatgt aaacaaaaat atctatgtag ctaaaatagt 51660
agtaaataaa taaataaaaa gaaaaaaaga aaggataata gcatatgtct aacttattat 51720
ttgttctttt tcattgtttt gtttcccata ctagtgcatt acagagggta tctagctatc 51780
tatatttaca aattagtggt atatacatat aacattttgt aaatatattc ctatcattca 51840
acaaacctta ttaatttacc atggttaagt gagaattgtt aacaagatgt gtattgatta 51900
attataattt aatgataata gtatacgtga agacataata ttatattttc attgtattgg 51960
taccaacact ggtgtcacac ccttttttac tccaaaagat ataagttatg gatcgtggat 52020
tgaagagttt tttcaattaa agtgacaaac ttgagtaggg attattttat ttacagagtc 52080
gtcgcttgga attggttttg ggtgttccaa gtcacctttt atatgaatac ttagtcagag 52140
gaagatttga ctctattatt attggtctgc aaaaataaag tctggataaa gaattctgtt 52200
gataggagag aaggtgtaag gcattccccg agtccagtga ttctagcacg gtcactttat 52260
tgacttaaat ttggcttgaa ttaattttgg attaactgtg ctttatttgg ttttcatgtt 52320
ttgcctatat ctgtttttat tgttgatgat tttattaatc tcaaactagg acgagtattc 52380
ccgatcctag cttacactaa ccaagacgag tgcccccgac cttagttcgt gcgttgtacc 52440
taaaattgga gcctactcga agttaattaa atagcaaact tttaattgat cgaaagaatt 52500
ggaacaagac gtgttctcat gaccttgcca ttttatttat atctttattt cgaatcgtgt 52560
cttctcgaca tcggttaaga caaaattaat tattggagag gttcgtgcat ccttattgtg 52620
aaaaaaataa acttctttgt agctagaaga taatgagttc gcatatggat aattaattga 52680
tgttggacca atttataacc ttacattaaa caaatgatga aacaagtata aactaagtat 52740
ttaagagagt tatccatatt cgtgcctaaa atttgcctaa cgcttaaatt aaattattag 52800
tgactaagtt attaaactgt tagttaaact ttaagagaag gttattcgac taacttagcg 52860
tgaagatttt gggacagctt aggatatagt aattattgat tatagaagat ggacctaaaa 52920
gcatcctagt aatatttgga ttaaaacagt aaggcaagaa aaaggcatgt atgtgattat 52980
ttaaagccac ccatggcata attttgaata cataatacac aagattttca tctaataggt 53040
aaggttctac tctcaaatcc taaatttcgg aatttggacc gaacgtagtc atgagaagta 53100
tgattcttag gtgtgggagt tgctctttgt acacgaatgt aaccataagg gtggtggggc 53160
ggttattgaa ctaaaaggag taaactcttg gtattgaatt ggttgtgggg tgaaggaaat 53220
cttgtagaag aaccttgtag tcaaatttgt acacctagtg tttgatgaaa tgcttaaatg 53280
aggtgaaacc ctcaatatct ttctaattta cgtttaattc tattatgtct caaaatagat 53340
tgagattgct aggattttcg gaatattgta gtaacttaag gaaagctcaa gcaaggtacg 53400
ttggctaaac tactatgatg acccaaaata tcatctttaa atttaataag taattctatg 53460
ttctaagaac tcaaaaagta ccatttatca ttcctcgact tgcgtgcgca gtccgtaaaa 53520
tttttcgaaa agttttcatg tgaaaaatgg attaaaatag gaaatagagt tttaaaactc 53580
aattaagtta atttaggtca acattttgag caaacggatc cggatcagta ttttgaaaat 53640
tcggataggt ccctatcgtg atttggtact tgggcgtatg cccggaattt aatttggagg 53700
tccctaactc aagttatgac catttgacgg aattagcaat ttaaaggcta aatatttcaa 53760
gtttgaccac ggagttgact ttttgatatc ggagccggaa tccgattctg gaaatttgaa 53820
cagcttcgtt atgccattta tgacttgtgt gccaaatttg aagtcattcc ggattcattt 53880
aatatgtttt ggcacgagat ttgcaaattg aaagtttaaa actcaaagtt cgaatcgggg 53940
tgtgaattgt aatttcagtg ttgtttgacg tgatttttga ccccgagtca gtccgtatta 54000
tgttacggga cttgttgtta tattcgaacg gggtcccgag tacctcgaaa gtgaaacgga 54060
tcaaaatcgg aacaagaatt ggacttaagc aaaaatctga aattttgagt tctggtgtaa 54120
tcgcacctgc agaattttga ccgcaggtgc gagctcgcag aagcgagact tccatcacag 54180
atgcggcctt cgcaggtgcg gcccttttgc gcagaagcgg acgtcgcagg tgcgatattt 54240
tgtccgcaga tgcggaactt cgcctggcag tcccttttcg cagatgcgag ctcgcatgtg 54300
cgagcccagg caccgtaaat gcgaatatac tgggcagaat acataaaatc gggtcttagc 54360
catttttact catttttgag ttttgagtct cgaatttagg tgatttttgg gcgattttta 54420
cgggaaaata ttggggtaag tgttccttat cctatattga ttatatttca tgatttcata 54480
ctcatttata tcatgaatct ctgaatttat ggaagaaaaa atagattttt ataaaatctt 54540
ccaaaaacga aaatttaaga tttgaaggtc catttgatat cggaattgga caaatttggt 54600
atggttgaac tcgtatcgga acgggtgttc aaatttcgcg agttttttca ggatttgaga 54660
cgtgggtccc actgtcgaat attttaatga atttcggatt tttatccgaa aaaattataa 54720
attcatatgg aattaattcc tatgattcgt attgaatata ttgaattgtt tgtgaataga 54780
tttgaaactt ttagaggcaa atgtaaaagg aaaagttgtg gttgaatagt tgattggaaa 54840
ttacaaagcg aggtaagtgt cggggttaac cttgacttga gggaatagaa cccttaaatt 54900
gttcgttatg tgaattgcat gtaaacgacg tataggtgag gtgacgagtg tctatacgtc 54960
gtcaaattaa ttgtttgcct gcttacttaa aaaattataa aaaattttta atcataaatt 55020
aattattata atatttgttt ctctcttatt ctttgcaaat ataaattttt gaattcctgc 55080
attaattgtt acatgctatt tgaattatgt gccttaattg ttatttgaca tttagcataa 55140
taaatattaa attgcctatt tgctccctga tttctctaat aatttgctat ttgtcattgt 55200
ttgcttcata attaaaccat aattattgta tgcttgttgt cttataattt tatattaatt 55260
gttatattta ttgggaaaat ttcttctata agaattggta aatgaaaatg ttggaggatc 55320
gggttgcacg ccgcaacaga cttattaaaa gtcaatatta gaggatcggg ttgcacgccg 55380
caacaaactt attaaaagcc aatattggag aatcgggttg cacgccgcaa caaacttatt 55440
aaaaagataa tattagagga tcgggttgca cgccgcaaca gacttgatta aaatgaataa 55500
gttggaggat cggattgcac gccgcaacag acttgattaa aatgaatatg ttggaggagc 55560
gggttgcacg ccgcaacaga aattgaatgt gaatatattg tgagagcggg ttgcacgcta 55620
taacagaatt ggttgacata ataatggatt atgattgctg ggttagtttc aattattata 55680
aatgagttac ctgatttatt tatattattt gttgttatta tcaatattgc gtacaggtta 55740
atgtaagtaa accgccttag cctcgtcact atttcatcga ggttaggctc aacacttacc 55800
agtatatggg gtcgattgta ctgatactat actctccact tcttgtgcag attttggaat 55860
tggtcccagc ggcgtaccat agatttgctc ggattttagc tactcggagg agacttgagg 55920
tataactgca tggcgtccgc agttctgaag tccccgtcta tctcacttta gctgtgtgtt 55980
tatttccaga cagctttatt ttattcagac ctttatttgt atttattcta gaagctcgtg 56040
cacttgtgac accaattttg ggatggtatt tagacaccgt tattattatg gattatttca 56100
aaattacttc cgcatttgct tccttgttat taataaattt taaaaaataa ttaaaatgga 56160
caatattatt ctaacgtcgg cttgcctagc aagtaaaatg ttaggcgcca tcacggtccg 56220
aaggtgagaa tttcgggtcg tgacagttgg tattagagca ctaggttaca taggtctcac 56280
gagtcacgag caagcttagt agggtttgaa ggatcagtac ggagacgtct gtacttatcc 56340
ctcagaggct atgaagttta ggaacaatat cacttctttc ttattctgtc gtgcgattct 56400
attctatcat caatgattga acaattctac tcttattctc tcgcagatgg tgagaacatg 56460
taatacttct accgatggac agtgaccaga acccccggtg gcaactatgg ccaggtgtag 56520
aggtcgaggc cgaggtcgtg ctagaggtcg aggcagaggc cgtggtagag ctcagtccag 56580
agctcgagta gctgcacctg ttgtagaacc tcagatagac cttcaggagg aggtcccagt 56640
tcagaatgta ccagttggac tagttcaggt cccggaagga ttcatagcca ctccagtact 56700
tcaggacgct ctagtccgat tggtgagtct tatggagggt gtggcccaga atggtacatt 56760
tccagtggca ccagccatct cacaggnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 56820
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 56880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 56940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 57000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 57060
nnncttattg aggctggata agtttactaa gctctttcca gttcacttaa gtggtacatc 57120
ttctgaggac ccacaggatt atcttgaacg ctgcctcgag gtgctgctaa acatgggtat 57180
agttgagacc aatggagttg attttgctgt attccagatg acgagttccg ccaagaggtg 57240
gtggagagat tatacattga cccgaccagt cggatcacct atacttacct gggagcagtt 57300
ctctcagcta tttctggaga agttcctccc tatcacactn gaattctgca agcaatttga 57360
gtgtctacag catggcagta tgattgttac tcagtatgag tcccgttttg tggatttggc 57420
ccgtcattct ctccttttac tacctacgga aggagagaga gtgatgaggt tcattgaggg 57480
actcaatcac cctatcagac ttcagatggc caaggagacc ggaaatgaga tttctttcaa 57540
gacgactgct aatgtcgcaa ggaggatcga gatggtcctt gcacaggaaa gggggcagag 57600
gtccgataag aggcctcatc agtttggtgg ttacagtggt gcctcgtcta aaggcagggg 57660
taattttggt aggggtcatc ctcccagacc gtttcattca acactttatg tatctcccgg 57720
tgcttcagag agtcacaatc ctattattcc ttactctggg cagccagtat tcagtgcaca 57780
ttcagctcct atcagtgcac caccactcca gagttactat agtggttatc cggcccatct 57840
gggtcagctt cagcttcagc agccacgaca tcaggatgga tgttatgagt gtgggaacat 57900
tggtcacatc acgaggtatt gccctagatt ggcgagtaac agatctcggc aagattctcg 57960
tgccatcata ccagcaccgg ttgcttcacc gccttctcag ctagctagag gtaggggtca 58020
ggcagttaga ggtggaggtc aggccattag aggtggaggt caggcnnnnn nnnnnnnnnn 58080
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58140
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58200
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58260
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58320
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58380
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58440
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58500
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58560
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58680
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58740
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58800
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58860
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58920
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 58980
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 59040
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 59100
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 59160
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 59220
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 59280
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 59340
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 59400
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 59460
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn ngcacacaat 59520
tccaggtatt ctattcatcc aggtaccgca aaaatgtatc aagatttgcg gcaacattat 59580
gggtggagga gaatgaaaaa ggataaagtt gcacatgtag ctcggtgtct gaattgtcag 59640
caagttaagt aggagcatca gagacctggt ggtttgtttc agaaattaga aattcctgag 59700
tggaagtggg agcgtatcac aatagatttt gttgttaggc tcccacggac tcagagaaaa 59760
tttgacgcag tttgggtcat tgtggacagg ctgaccaagt cagcacattt cattccagtg 59820
gcagttacct attcttcaga aaggttagct gaaatttata ttcgtgagat tgtctgcctt 59880
cacggtgtgc ccgtgtctat tatttcagat cgaggtacgc agtttacctc acatttctgg 59940
agggatgtac aacgtgagtt aggcacgcac gtggagttga gtacaacatt tcatccacag 60000
acagacggac agtcagagcg cactattcag atattggaag atatgctccg cgcttgtgtt 60060
atagactttg gaggttcttg ggatcaattc tttccacttg tggagtttcc ttataataat 60120
agctaccaat cgagtattca gatggcttca tatgaggcat tatacggaag gtgatgtcga 60180
tcaccagttg gttggtttga accgggagag gctcggttgt tgggtaccga tttggtacag 60240
gatgccttgg ataaggtcaa gattattcag gatcgacttc gcacagctca gtctaggcaa 60300
aagagttatg ccgaccgtaa agttcgtgaa attgcattca tggtcggaga acgaatattg 60360
ctccgggttt cacctatgaa atgtgtaatg aggttcggaa agaagggcaa gttgagccct 60420
aagtatatcg gaccctttga aattctggaa agggtgggtg aagtagccta caggattgca 60480
ttaccaccta gtttatcagc ggttcatccg gtgttccatg tgtctatgct ccggaaatat 60540
catggtaaac cgtcccatgt gttagatttc agttcagtcc aattggacaa agatttgact 60600
tacgaggagg agtcggtggc tattctagcc cggcagatcc gacagttgag gtcaaagagt 60660
tatccttcag ttcgggtgca atagagaggt cagccggtag aggcatctac ttgggagttc 60720
gagtcggaca tgcggagtaa atatccacac cttttctcca gctcaagtac tttttctaac 60780
tctattcgag gacgaacgtt tattttagag gtggagaatg tgatgaccca aaatgtcatc 60840
tttaaattta ataagtaatt ctatgtccta agacctcaaa agcaccattt atcattcctc 60900
gacttgcgtg cgcagtccgt aaaatttttc gaaaagtttt catgtgaaaa atggattaaa 60960
atgggaaata gagctttaaa actcaactaa gttgactttg gtcaatattt tgagcaaacg 61020
gatccggatc agtgttttaa aaattttggt aggtccgtat cgtgatttgg gacttgggcg 61080
tatgcccaga atttaatttg gaggtcccta actcaagtta tgaccattta acggaattaa 61140
caatttaaag gctaaatatt ccaagtttga ccacggggtt gactttttga tataggagcc 61200
ggaatccgat tctgaaaatt agaacagctc gttttgccat ttatgacttg tttgccaaat 61260
ttgaagtcat tccggattca cttaatatgt tttggcacga gatttgcaaa ttgaaagttt 61320
aaaactcaaa gtttgaatcg tggtgtgaat tataatttca gtgttgtttg acatgatttt 61380
agaccccgag tcagtccgta ttatgttacg ggacttgttg gtatattcga acggggtccc 61440
gagtacccca aaagtgaaac ggatcgaaat cagaacaaga attcgactta aacaaaaatc 61500
taaaattttg agttctagtg taatcgcact tgtgaaattt tgaccgcagg tgcgagctcg 61560
cagaagtgag acttccatcg tagatgcggt cttcgcaggt tcggcccttt tgcacagaag 61620
cggacgtcgc aggagcgaca ttttgtccgc agatgcggaa cctcgcctag cagactcttt 61680
tcacagatgc gagatatttc tcgcagatgc gagctcgcat gtgcgagccc aggcaccata 61740
gatgcgaaaa tactgggcaa aatacataaa atcgggtctt agccattttt actcattttt 61800
tagttttgag tctcggattt aggcgatatt tgggtgattt ttacgggaaa atattggggt 61860
aagtgttcct tatcctatat tgattaaatt tcatgatttc atactcattt atatcatgaa 61920
tcagtgaatt tatggaagaa aaattagatt tttataaaat catccaaaaa cgaaaattta 61980
agatttgaag gtccatttga tatcggaatt ggacaaattt ggtatggttg aactcgcatc 62040
gtaacgggtg ttcggatttc gcgagttttt ccaggatttg agacgtgggt ttcactgccg 62100
aatattttaa tgaatttcga atttttatcc gaaaaatttg taaattcata tggaattaat 62160
ttctatgatt agtattgaat atattaaatt atttgtgaat agatttgaag ctttcagagg 62220
caaatttaaa aggaaaagtt gtggttgaat agttgattgg aaattacaaa gcgaggtaag 62280
tgtcgagtta accttgactt gaaggaatag aacccttaaa ttgttcgtta tgtgaattgc 62340
atgtaaacga cgtatgggcg aggtgacgag tgtctataca tcgtcaaatt aattgtttgc 62400
ctgcttactt gaaaaattat aaattatttt taatcataca ttaattattc taatatttgt 62460
ttctctctta ttctttgcaa atataaattc ttgaattcct gcattaattg ttacatgcta 62520
tttgaattat gtgccttaat tgttatttga catttagcat aataaatatt aaactgtcta 62580
tttgctccct gatttctcta ataatttgct atttgtcatt gtttgcttca taattaaatc 62640
ataattattg tatgcttgtt gtcttataat tttatattaa ttgttacatt tattgggaaa 62700
attgcttcta taagaattgg taaatgaaaa tgttggagga gcaggttgca cgccgcaaca 62760
tgattaatta taatgaatat attgaaggat cgggttgaac gccgcaacag acttattaaa 62820
agtcaatatt agaggatcgg gttgcacacc gcaacagact tattaaaagt caatattaga 62880
ggatcggatt gcacgccgca acagacttat taaaagtcaa tattggagaa tcgggttgca 62940
cgtcgcaaca aacttgttaa aaagttaata ttggaggatc gggttgcacg ccgcaacaga 63000
aattgaacgt gaatatattg tgagagcggg ttgcacactg caacagaatt agttgaaata 63060
ataatggatt atgactactg ggttagtttc aattattata aatgagttac ctgatttatt 63120
tatattattt attattatta tcaatattgc gtacaggtta atgtaagtga accgccttag 63180
cctcgtcact acttcgtcga ggttaggctc atcacttact agtacatggg gtcggttgta 63240
ctgatactat actctccact tcttgtgcag attttggagt tggtcccagc ggcgtaccat 63300
agacttgctc gaatttcagc tactttgagg agacttgagg tataactgca tggcatccgc 63360
agttctaaag tccccgttta tctcacttta actgtgtgtt tatttccaga cagctttatt 63420
ttattcagac ctttatttgt atttattcta gaagctcgtg cacttgtgac accaattctg 63480
ggatggtatt tagacaccgt tattattatg aattatttta aaatttcttt cgcattttct 63540
tccttgttat taataaattt aaaaatattt ttaaaatgga caatattatt ctaacgttgg 63600
cttgcctagc aagtgaaatg ttaagcgtca tcacggttcg aaggtgggaa tttcgggtcg 63660
tgacaactac tctcttagaa ttgaattcca tgatgttcct gtatgtttca agtatggtcg 63720
gctcaagttc cttattccca tgttccgagt tgttcccaat aaatttgatt gtcccgagta 63780
agcaaagtgt cgagaattat gtattcaaaa tatattccgg atattcctat cacattatat 63840
tatccttcgg gagtgtgttc aagaatgata tgtgtattaa aatgttatgg ctttgagtcg 63900
tgtttcaaat gaaagtccat tatgctttac ttggaaaaac tactacatgc gtctaaaact 63960
cctattgctc aaatgtgtat ttaaagtctt gagtagaaat gccttgttgt tgataatcta 64020
taaggatgct tgaaagtgaa agaagtgggt tggagatata aagtgtggcc aacgtgccaa 64080
gaatgagagt tttacttgtg gtcaatgggg tcgaggaaat gaaatgatgt gagaaaagtt 64140
atgaaatagg ccttgattta attgtcccaa attgacctcg aaaatagatt tgcctaaaag 64200
cttatgtacc caagttatgc ccaaatgtga ttgttttaac taatgctatg ctttgttagt 64260
atttccaatg ttttttgagc tcttatgtct tcatgagttg aaattgtata ttgccctttt 64320
tggagaaaag tatttcaaga acaaatgatg tgttacacgt ttatgatttt aatttgtgct 64380
tcgattgcga atccatttac tcaatttctt gaaaagaaat tcattgtgtt taaagtcttc 64440
attgctaata acctaaagtt gtgattttcg gagaattcta tttgttgata tttatgatga 64500
tgatccatga aagaaaagga aataattaaa gtgtggaatg tggaatacga ccattgtgcc 64560
atgaataaag aattatatat atggccaaga gagccaataa aataatgatg ttgaaagtgg 64620
ttgaaagtgc caatgaggct ataaatggtg tgaaaggtta tgaggtaaat gtaattgtat 64680
atctgtttcc cttgtatgaa aatcaaaaat attttttttt tctggagtat cgttagtcag 64740
tgaggaaggg taggttgaca taacctaacc ccggaataca cctccgcccg catacattgt 64800
ggtgaggtgg catggttgct ttgtgtagag attgtgattg tgaatacacc tccacccgca 64860
tacattgggg tgaggcgaca tgaccacttt gtgtaggtat tttgattgtg aatacacctc 64920
cacctgcaca cattggggtg aggcggcaga gccactatga atagagaatg tggtattgaa 64980
attacaccta cacccgcacg cattggggtg aggcggcatg gccactttgt gtagagaatg 65040
tggtattgaa attacacctc cacccgcacg cattggggtg aggcggcggg gccgctttgt 65100
gtagaggttg ttacaaggga tctcccaacc aaaaatcata ttactatcgc gttttgaaaa 65160
ttgttatgtt ttaacttggc atttggatat cattgatcgt tgcttgttgt ttccatggtt 65220
tttttttttt tttttaatat tggcatacta ttttgaaaga ggacaattag ctttacatac 65280
taatactatt ctatatgaac taatgtccct ttagttgggg gcgctgcatc ttcaattgat 65340
gcaagtagct cgacaacagt caactttgga tctcattagt agttactccc tattcaacag 65400
gttttggtga tccctactct attctgggcc tcatgtcact tgatgttgta ctttgtgttt 65460
tgaggtatag ccggggcctt gttgtcggca cttttatact actcttttgt tctacttaga 65520
ggctccgtag ataggttgtg ggtggtgttt gatattgggt aatgagctag aagtgttggt 65580
atttggcaaa catgttttcc ttgtaattat gaacttgtaa tattttgaaa attataaatt 65640
gaatctcctt gagtaatgaa aaagaatgtg gagcacttga ttcttctcac atatatttct 65700
agccactgat tcttatattg ctgatgggca agattaggta gaaggcatct aggaggcttt 65760
cttgatcagg gtatctcggt tgagcgtcgg tcgcgctccc cgaggtcgag cgtgacaact 65820
agcttcaatg aaatcgacaa taaaacctcg cttgaggccg gtatgaatgc agcaaaggct 65880
aaatctcgga gatcttgagt ggttcagggg cggcagtaga gtggccggcg gcagtgggag 65940
tggttggacg gaggtagtcg ggttccggag gtaaaactaa aggaacgttt atgtgaaatt 66000
tgtgtggtgg tttggtcgga tttgcaatga aatcaaagag ggaagtaaga ggtagctatc 66060
tagggtttcg atttcatgat tttcgggatt ttgattgtgc accgccggta gtggcgattt 66120
acggcaggca gagccaccgt ggggagggtg acagcggcag aagtgggaag agggagaaga 66180
gagagctaag ggtgagagga aagaaagagt aaaaggaaaa atggggtcgt caaaatttcg 66240
gagggtaaag gcgttaaata cctagttgag agattgaatg ctagtcactg gatcaaggaa 66300
gatcggatgg atggggattg atatctaacc atttatccaa aacgacgtag ttttaggtta 66360
aactgcgccg ttttgaatcc gcccctgaca ggccctctat tagaccgggt taggctgcca 66420
atttgcctca tatattggcc caatctcggc tcacaaatgc aaaacccaat ccttttaacc 66480
ccgtaacaaa ctaattaata atctaattct aaaatctata aacacacaca gtaaacctag 66540
gggaaaaaaa tagtgtagga gaagtagaaa gagaaaatat tagatattta caactggttg 66600
taagtaagct ttttccaccc caacccatat cctttgacac ttgaccatca ctttttatcc 66660
gtttataatt aggaaatgtt actagtatat agtaacttaa ttgaaattta aaaataaaaa 66720
cagtgacata gtggttggaa aaaaataatc gacttctctt attttaaatg tgcaacagat 66780
gaaccagagt acaaggacta aagctatcat tactgctaag tacgaaactt aaggttgaat 66840
gcacttagga cttgggaggg aaaaatcttt ttcctctcat tctcttttcc tatctttagg 66900
tcacatacat tcaaagagtg aagcagttgg actagtatat gtcacatata tgtctttaaa 66960
acagtactat aaatataaaa taaccacgtg aaatgtatgt aaacaatgta tatagaaaat 67020
atacatacac aacaaatgga aaaattcaga ttatctgcat tgttacgtta tccaaaatta 67080
caaagcatgg ttgatatttt tactttccga taagacctat aagaatgaag ttcccaaaat 67140
tatagccaag aaaagagact aaacaaagct ctctcatcat gctattcatg aacttcagtc 67200
ttcagttcct ataaacaaaa ttagcatttg cataaaagca accaaaataa aaccaaaaaa 67260
aaactcttat ctttcttgag ttgcaaaaaa aaaaaaagga agattagaga ttagttatgt 67320
atacatccct tgctaactag atttcctcat atagaccatg gccttgtgat gaggagttct 67380
atgtgtcatt ccacacagtg aaagtggggg ccccaccatg acaaatagcg acagtattat 67440
tccttgaagc gagagcagga acagctgttg acatccaatt gttacaatta acagactcct 67500
gatgatcata aagaccggcc acctttacta agccattaga tgttgattgt tgagaatgat 67560
agtaaccaaa tatattctca ttaccaagtt gttgcttcac ttcattctct ccatatccat 67620
taccttggct caattgtggc aacgcaaatc caccactggg actacttgca tatccaactc 67680
cttgatatgt aacattatta tgttccattg aagtagaaga agtatccaat cccataagat 67740
tgtgtaaagc tgaagttggt tgcaagaaat tatgagcaat attcccatgt tgaagttgat 67800
gaaaatcttg aaaattttga gtactactca aatgatcaga atcttgaact tcttgtttgc 67860
accatagcct ttgttgttgc tgttgttgtt ggctataagg gtaatgcata ttcaatggct 67920
gagcctgagc ttgttggaat gcaatgttag accagatatg attcgcgttc gcgccatagc 67980
tactaattgt tccatttgtg agatgagatc caatgttttc ttgactaact ctttgataat 68040
ctagagcaat ttgatcagct tgttcagcat ctttgagacg tttagctgca cctccaatag 68100
gtaaggtact gctctctaat atgcttttta cgtcgtatcg gtttatttca aagttggtta 68160
ctgcatttag tccacggaat ttgattgctg ctatgtcata agcctctgca gcttcttctt 68220
gtgtgcctat aaagaggaat aaagttagaa ggtaaacatc ataatatgat tttccaggat 68280
aatggtttat ggaaaaagca gttttgtaca ttgactatat acctaagagg tcatttggta 68340
cgcgggataa ggtgggataa ggtaagagat taaatttata ccatgtttgg ttgatggtat 68400
aaatttatcg gtataaattt tattccagac ttaaaactaa aactggatat ctcacgctat 68460
ccccttatcc cattaaactt ggaatttttt atccagagat tataatcatg tgattattat 68520
ccgaggataa cttagtccgc ttaccaaacg acccctaagg acataatatg acactatacc 68580
tatttaatag tcttttggag cgaaaaaaag cctaaatagt catccatcca gaagcgaagc 68640
cacgatttga agtttataag ttctaaattt gtttataaag ggtataaaca aaaactgtta 68700
ggttcgccca aacctgtaga tgatacacta gctccgcccc tacgtcgacc caaccactta 68760
aactaaatat agctggtgga tatacaatat gcatataatc catgtatact ttgagtataa 68820
cgtgtacaat cagtgaataa tttatgtatg ctagctagaa aaagtaaata gttaatttgg 68880
acggctattt gtgtaaattc caaaaaaaag agaaaaaaga cttactgaaa gtgccaagat 68940
aaagatcctt gtttccagca actcgtccaa ttcttgcttg ccatcttcca tgttgatggt 69000
gccttttatt acaaaaaaaa aattacaaac ctaagttatt tttctttact attttaggaa 69060
agaagatttt aagcaagagc caaatgatag catacactaa aagaaatcac atattacctt 69120
gtaacacctc gataaatgga tgcaccacga gagaacccac tactcttcct atattaggga 69180
ccagaaaaca aattaaaaaa gaaaaatatt aatttcattc attttctcgc cataattttt 69240
catataaaca tgttttaaac taacatcaag tgttcagtag gtcagactaa aataatacgt 69300
cttaataaaa atatttgaca agattagagg tcaatctatg tatttcgctt tttttcttaa 69360
aacttgatta attaatgtat agctttaaaa tttaccttcg caaagatgcc acatactctt 69420
gtctagtcat atgcttcatt tcatccagct ctttctcata attactaatc tgaaaatttt 69480
gcatccaaaa taaaaaatta aattaaattt tctttacgga aataaatatg ttttcttacc 69540
aactagacaa atttcccagg atatagagaa gtcctagaat tctatgtact tactgggaaa 69600
ttggtggtag ttgtcggacc ccaatacttc agtgctgcta aatcataagc tcgagctgcc 69660
ttttcttctt tatcataccc tcctattaaa gatttacaag aaaaaataga tcagttagat 69720
aaaattataa aaaaaaaact aacttataaa aattgacagt ataaagaagt taacattctc 69780
gtgaatttta aaatttattg taacaattaa catgtcttat tttcttggtt gctaattccc 69840
tttttttaac ctatatttac tatactattt aggtaacatg atagtgtaaa aaatttgtta 69900
ctgtctaaac gttaaaagca ttgataaaat agtgagttct tgcattatag taacatgttg 69960
aaaagtgtaa gtgtatatat acaaagatta gaaggaatta cattataact tacccaaata 70020
aactgtagga agtatacaaa tgtcgaatcc atcaacatga aatagaagga gagaaaaatg 70080
aagaagatat ccaagttagt attttaaagg aaaaaagaag gtatatagta gtttaaaaaa 70140
aaaaagtaat ggcgagtaaa atgaagaaaa aaaaagtgaa attatatagt gggagacaat 70200
gaagggaaac ataccttgcc ttcctttgcg agtttgtccc tctcttctgc aactattatc 70260
ccacaaatgt gcctcatatc tccccgtcca cctatgccta catacaccaa tatataaaat 70320
taattacaaa acgtatatca caaataaaat acttacttta cacttaatat caaccactaa 70380
ataaagcaag aggaacaaga aagaaatttg gttataaagg ttgtttaaaa taagagaaaa 70440
aaatttcgtt tcgagtagta gatcatttta gggtagactt gntacatata ttggcatcaa 70500
ttacgcctta gtcccagaca aataaattac gaaatgtata tcacaaataa aatacttact 70560
ttacacttaa tatcaaccac taaatgaagc aagaggaaca agaaagagat ttggttataa 70620
ttaaaggttg tttaaataaa aagaacgaaa tttctttttt gagtagtata tcatttggtg 70680
ccttcttaag tgacgataat ccaatagtga aactaaggat tccattattt acgtttttgt 70740
tttggtacta agcacaaaaa aaaaataaag aataacaaga gaaactatat agggagaaat 70800
gggaagaatg aggctaaata tatttaaaga cgattttgta gttttttttt aactcccttc 70860
ccacttttgt aaggcaatct tgtactccat tttagacttc tcttgaggac aaagttcatt 70920
agaaattttc ctatatgtaa tatgtctcat aaatatagta tattttgatt tttaaaaaat 70980
aagaatgcaa gaaatgctac ttcgttcttt ttttcaaagt agcatttatt tctctaaaac 71040
agccaaaaag ggcggaagtg gcctcgatct tacctataaa atatagcgac aattcaaaaa 71100
aaaggaaata gacaatacct tgtaacacca cggtaaatcg aagttctttg gccaaaagta 71160
tcaatagatt tccgaggtac tgcttctatt gcaccattat tttgtgcatc aatactacca 71220
tttgtaccat ttgcattctc ttgttgtttg ttattttccg acgagcaact attctctcca 71280
ccaccgccac cgccaccacc ggtgctcata gaaagtgaca aggactgtgc attattacca 71340
ccacccacca ccacaccctc cccctccttt ttatcatctt gtaatgatgg ggtgcttgta 71400
ttagggttat ttcttaacca attcttgatc atagaaagcc ctatagtatt attattagtg 71460
ttacttccaa tattgttagt ggtactagta acactagaat aaatactata atctccatta 71520
atgttgttgt tgttgttgtt ttgtacttca ccaataccaa ggaagttttc tagttttggt 71580
ggttcttgat tttcaagatg ttggctagta ttgcatgaaa tacccattag cattgacatc 71640
tctgatgttg ttttgtagtt aggatcatga gagctccaat ctgcatatac aaaacaaaca 71700
aaaaaatctc aaaaataggc aaaatagttg atttttttta attaatccat ttaatcggac 71760
tttcacctcc tgtggtgatg aggggttttg acataaaccc caaatatgta taattaaaac 71820
catagtattg catctaacaa aaatcgttct taatttgtct aattcatccg aggtaaataa 71880
aggacaacaa caacaactca gtataataca gagtctgtgg aggataatgt gtacgcagaa 71940
cttacgccta tcttggtgga tagaaaggct attttgcata gacccttaga tcaagaagat 72000
gaaaagagac aatagaacaa taacatcaac ccaagcaaac aaaggaggaa ctgcaaaaaa 72060
tggctataaa ctttcacaac atatgtgtct gatcttgata ttttctcctt gttttcattt 72120
gaaatattag ggtttttagt agtaaaaaaa gagactaaca aagaggaaat taaattaaat 72180
gtagtaacta accttgtgat tgatgatttc tgttgaaagc ttcaaaaata ccaaaagggg 72240
tatgaggaac aacattaaga gaaggaagtg tagagtcatg agaagtaaga tcaaagcatt 72300
ctcctgaaac atcaactgaa cctgatattt cttgagatgt ttgtgatgtt aattcctcat 72360
gtggtgaaag agagaatcct aaccagttgt tcatagatga agccatcaaa ttaatatctt 72420
ggttaaaatt tttttaaaaa aattacttca ctagttatat ataactattg aaaaacacta 72480
gtaacattga ttttttcccc tctaaaagtt catgcaatat gaagtgctac tggaaattaa 72540
aagagaagaa aaagataagt ccatgagtta gccatatagt ctataagttg tttgaaggtg 72600
aaaaaaagaa agaagaagaa gaggaaaggt ccaaaaactg aagaggaatc atttctccca 72660
aagcaaggtt aagatttata tgaaactcaa aacccaaaaa aagaagaaaa aaatcaagtt 72720
cgaccccccc tcccccnctc taaatgaggg gcagtgtttt ctctgatccc aaaaacatgt 72780
ataggttcaa aatgaagagc aaaatatagg gttgatgagg ggtaggattg taaaataatt 72840
gaaccaaggg tagtagtata acaaggacat ttcctctttg gttctactta tctatagcct 72900
attcttcttc actctatgtt taactttcta tacacggata atatgcaaat ttttgcatta 72960
tcaacttaag ttagacttat aataacagat acgatataat atgtttagct atcccgattt 73020
agtaaactaa aaatgcaaaa aataacatgt tgtaaccggt taaacgatac tttttttttg 73080
tttttcgtcc ggtgtccggt acccgtattg gagcccaact atatatattt gtaatcacgc 73140
cgcataggac cccattcgag gggaaagact ctctaccaaa tatttttcca tacccagagc 73200
tcgaacccga gaggttacat tgtttaatga gttaaatctt ttttttgttg ctaaacaact 73260
atagcttgaa ctttactgtt actacgaaat tctatacgca tatcaaatgg aagctaagat 73320
aaaagaataa taatcaagag tacacgagga ctaaataaaa aattgtgtga attgtagcct 73380
tctgtactta ctaatagttt attttggcag atatatccta atattttagt tttcatatct 73440
aatccttttc ttgtgtaatc taaagatcgg gcaaagtggt atatagcatg ttgagatagt 73500
tgatcctatc tttttcattc ttgcatatct tctactccat ttttttcatt atttgaatgt 73560
ccgataatcg cattggaatt cgattaaatc cggattcgtt tcaattagcg gattataaag 73620
cactcctaat ataggtgact ctatatctca ggctcaaatc tgaaatctct aattaaaaaa 73680
tgaagtagtt actactccac tataaccgtt gttgtaatat cttctactca attgtttgaa 73740
gtgtatataa tttgaggcag tattattcta taaatagtta ttggcctaac acatggagtc 73800
atgcatattc tttgggggca tgtggtttct taattttgaa ataaactgca ctaatgttct 73860
ttgaacgttc aaagagtatc caagttgcac tcttatttta cccatttttt gttgcctata 73920
ttattggcta aactcatttg caagaacttt aagaaaggca ttccttgttt ctataccaaa 73980
tctctcttag tttattatag gaatagggta cgtaacacaa tttatttttg ttgcctgaac 74040
tgttgaacat atatctcttc ccatctctca cttagtcaag gttgacaagt tcaataattg 74100
taggatatta ctaattaaga aagatattta ataaatgttt taaatactta cttaacactc 74160
caccaattag aataatatga ttgatttggg ccaaaaaaaa aataatttcg gtgcataatg 74220
catcccgcgt tcacgtagga tctagggagg ggcgcactca taaagagtgt attgtagaca 74280
acctatatcc taatgcaagt attagtggtt gcttcgacgg ctcaaacccg taacctatat 74340
agatcacaca tagacaaatt tatcgttctc caaaactccc ttcagtatgg ttgatttggg 74400
aaaatataat aaagagtcct tttttataca acattcaata ttttgaaaca aacttagttg 74460
gccaaaacga gtaattaatg ttttggacta aaggggatac attaatgaat aagataactt 74520
gattgcaaat catgtttaaa ttcaactcag atcagaaaaa cgttgactct ataaaaagtg 74580
atttctataa atgtagacca agtatatata taccgaatta gtctataatt tttctactga 74640
tcaggaactc atggaaattg ttaattacaa cattaatttg tgccttttaa atcgtttagc 74700
taagataata ctagtccaat atcgtagttg taatacataa agcctgatca ttggtatgga 74760
accaggaatt ttaatcagtg gattcaaata aatacaagga acaccacatg atttaattaa 74820
gtttcagaca tgcgatctaa acaatatttg agcaaatttt aaaccacatt caaatctttc 74880
tctatatgaa gaaaaaattc gacaataata tatatatata actaattact tactaatttt 74940
ctatttcgaa ttaaaattta ttattagtgc aagaaaatat gtatattctt gtatataatt 75000
taaatacatc tatttattca ctgaatggga acttctgagt aagattaaag ttattttcat 75060
gtgacctata agtcacgagt ttcattcgta aaaataacca ctaatagacc attcgcacca 75120
cacttttgga gtgcgaccct tctcccaacg acagaagcgg acctatgtaa tagaatgagg 75180
ggtcaccagc accgtaatat tcggcaaaaa tctcatgtat acatgttttt acaaaataat 75240
gatatattag tagtgatacc ttatatataa agtaaatttt ggctgaacgt aaatgtgcac 75300
atattacctc taaattttgg atttgcctct gttgaacaac atataaatac ggaatgattt 75360
gtgtattgaa ttatcttttt ttacgtcatt ttattcagtg aatttccagt tggatataag 75420
tcatatcaat gtcagaaatc ctggtcctct tcttcctttt ctcttcctct atctgtaatc 75480
tgtccactgc cacacccctt aacctaacca acccactact tttcatttaa ttttttttct 75540
ttttcactcc cataactttc tcacattctt ttgccatctt ttaaaaaagt ttaatttatt 75600
attttttgca tgttgctgct gctgtttatc ctcagcttgt cataatcatc aaactgctcc 75660
cccgatagaa acgggggact tttcttttcc ttctttttaa aaataataat aattcatttg 75720
catgactgac acttaataat tcttcccctt ttatatattc tcctttttta ggcagatcat 75780
tttagagaaa ctgagatact cagaatcttt ttctttttcc tttttagaac gggcttggct 75840
tagctctttt tagtcttttg acacgtagta gcacgtaatg tagtcaatca tatacttcta 75900
actaggggta tataagtcgg gttgcgccgg cgaaactaga actttttttg agagtgttct 75960
aatttgaaaa aagtaaaaag aaattcttat aaagggtatt caatatatgt tatatacctc 76020
taaaacttga tattttattt atatacgcag tgtaattttt tgacaaaggg tgatcaatat 76080
aaagtgtggc ttcgcccctg tcgggctggt tcaattttta tcaaaatcaa actaaaacaa 76140
acctagttga atttttaaat cgatttgatt tgacttttcg atttggtgat tttgctggtt 76200
cgatttgaca cccctacttt taacaaggat tggaggtagg ggtgtacatg gatcgagttg 76260
gtttggtttt gacaaaaatc aaaccaaact aactatatcg atttggattg gttcgggttt 76320
gtcgggtttt ttgttactta aatattattt caattttact ttgttaaatt ttttataagt 76380
aaatatatgt ttagtaaaaa tataaaaaat gataaatata ttatctatta aaatattctt 76440
ataggagatt ttttagtaac acatgatagt tatttttttt agtcgtctgg caataatttc 76500
tcgttgatat atactttcaa ggttaaccga atttagtaat taaacataaa aattaatatg 76560
atacataaat aataataacc acttcaaatt cgaaaaagat ataagaattt aatagatctt 76620
gaaatatgaa tatggaagaa catagattga cgcatttcag taacacttga taagaaagtg 76680
atcatacaac ccattattta ggtgaaagaa aaacttattg atccccacca cacaaaagtt 76740
acttacaagt gatattttca atccttaatc tataatctat cctatctagc tcaatgtcaa 76800
aattatatct ttattctctt ctccttgaga atccctacta ggtaggtttg cccggttaga 76860
agctagtcct acactattgc aaagccgttg ttatttctct atatgtacaa ttgattgatc 76920
cactttattt ctttcctatt cttcatgttg gcttctatga attgtagtct gtatttgcta 76980
tcctctttta tgttcttcca catctttgtt ggcaatggta ctttctgatt ccatagtgct 77040
tcattccttg ctcgccatat cccatgcatt actgatgtga tgattgaggt tacgaatcct 77100
cgacatattc tcccttttat acatctaccc attttcttcc aaatgttttg catatctagt 77160
tgtttcaact ttattcccag ccagttgcat tgttcatcta tgcacattct ggagaattga 77220
cacacagagt acaaatgatg aattgtttca tcccgcattc tacatagtag acatgttctc 77280
ttatggctta ttcccatcat atgtagtatg tctcgtaagt aatctttgtc tcatgatcaa 77340
ccatcctata aaataatatt ttggaatatt taatctattc taaatctatc gtgcatatgg 77400
acatttaggt gttgctcctc ttctccatta gtatccttca tttactatgt acccctttat 77460
ttgccccttc catctttttt gttcaaaccc tgcagcaaag gctgtttgga tatcacatat 77520
ctttttctaa taccatgcac tatcttgtgg tggtttgtat tgccaccagt ccttgccctt 77580
tatgtatatg tgatttaccc atttaaacca taataaatca cttttttgct ctatatttca 77640
tatatatttt gccaatgctg cttcattcca taccaaacag tattgtattc ctaatccact 77700
ctctattttt gttcggcaga ctaggtccca tgctacctgt gggaatttgt tcgtgacact 77760
tttctcatcc tataggtagt tcctacatat agttacaatg tccttcatga ccctttttgg 77820
tagtaagaag atggatgccc aatatgagtg taggtacaac aacattgtat ttaccaactg 77880
agttctccct gcatacgata ggttcctgga tccccatcct tttttcttta ccagtatctt 77940
gtctatcaac atttcacact ctacaacact tagtttcttt gaggatatag gcactctaag 78000
atatttaaat gaaagtttac ctctcttata tcctgtcagt tcatatatgt ctttcatctc 78060
tctaccattc atattcacat agaagatgtt cgatttattt gcattaacag tcataccaga 78120
tgcattcgaa aatgatttga gtccccttag catgagcatt actgatggat aatctccttt 78180
actaaatagt atcatatcgt ccgcaaaaca aaggtgtgtc atcttcaatc cttttcattt 78240
tgtatgaaaa gcaaattctt cctacttagc cacacgcacc atgatgcgcg tgaaatattc 78300
catatagatc acaaacagta aaggagagat tggatccctc tgtcttaatc ctctcttctt 78360
atttattttg ccataacacc caccatttaa gtttatgttg tagctagttg atgtgataca 78420
tgccataatc caccttatga agaactcggg aaagtttagt gcatgcaaca tttcctccac 78480
aaattttcat taaatggaat catatgccct ctttaaatcc accttgatta agcagctttt 78540
agtggtttgt ttcctattgt ataatttgac caagtcttga caaatcaaga tgttttatac 78600
tataattctc ccaaccacaa aggcactttg attttgtgat atgatgtctg acagtaccaa 78660
ttttaatatg ttacacaaca tctttaagat aattttgtac accgcattat atcatgctat 78720
aggtatataa tcttcaactg ttacaacatg agaggttttt ggtatgaggg tgatcattgt 78780
actattaaga ggtctgagca tttttccaga ttgaaaaaat tccaatacaa ctgcagtgac 78840
atcctcacct acaatggtcc agctatcctt gaaaaattgg ctgccatacc cattatggca 78900
tggtgccttt gtccctctta tatcccattg tgcttcttta acttgctttt gtgaaaaatc 78960
ttctatcaac tcgatccttt gttcttttga aacaatatgt ccttctttga ctatgtggct 79020
tgccacatga tctctgctct actggttagt gccctgtagc cttgtataga attcactaaa 79080
agtatcagct actgaatctg ttgattgaat tgtttccttg catgttctga attgtaaata 79140
tcatacttga tgctctcttt gccttaatca ccgagtgaaa gcagcttgtg ttcatgtctc 79200
catatttaag ccattgtatt ttactcgtct gttgcaagta gtttattttt gcttccttcc 79260
agtatatgta ttgcttcgtc aactctttct cttctttgaa tagtagttca ttcctaggtt 79320
ccttttgtat tttctcttga cactttacca gctttttcat gcgttcatct tcctgtttct 79380
ccacttttgc aaacttgtct taatttaact ttatcaacac ctttttaagt ttgtttaatt 79440
tttccaccac tttaaatatg tttgtcccct ttataggttg tctccagcta ccctccactc 79500
ttgtcatgta ggaattatcc ttgctccaca tgtgtgtagt atctgaatat cctcatctta 79560
ggtgtgtcag ttccctccca tttaatcatt acaagactat gatcatatac tcctgctggc 79620
atataataaa cctcagatgc tggcaaccta ttcacccagt caatattggt gatcaccttg 79680
tcaatcttgc ttagtactct atcttgtcca tcttgtttat tgctccatgt ataaaaacac 79740
cccgatgatt tcaattcttt tagtccacgt tgctcaacat actccttaaa ctcctttatt 79800
tctgcataag ccaccttact tcccactcta tcctcttgat tgagtataaa gttaaaatct 79860
ctcataattg tccatgtctc taccatttga ttagctatca tccttatgtc tctccataag 79920
tcagacctta gtgttggatt attgaatcca tataccatta tcatattaat caccttacct 79980
gtactactat gagtaatcat actatgtcta agttgttctg tcaccatttt cacttttata 80040
gcgaagatct gaggcttcca caatagccaa attctacctg cattatgttt agagtaattt 80100
gtagtatacg aacaccttgt gcaaagatta agagtagctt gatttgcctt agctctctta 80160
atttttattt ccaaaagccc aaacagtcca acctgttgtc tttgaaggaa catgttcact 80220
tccttctgct tggttgtcct gtttaggccc atattgttcc aaaaatcaat actatctatt 80280
aggggggtgg gggtttggtc ccccatcatt ccctgattta ttaccatttt cttgtgattc 80340
catctgcttt tcattagatt gtttctcacc ttcaatcctt tcattattcc tcttattcgg 80400
ttgtgttact gcagcatgag tgttttgatt gtttcctcga cccttccatg ctttttccct 80460
tgtaccactt gccatgcttc ctccactttt ttgttatttt ctgcctgatt cttagttccc 80520
tgtgtctctt gttgcttgtc tttggtacta ccattttcag ttggagttat gttacttgct 80580
tcaatgtttt gttattgttc atctggttct tccctctctt tgtagctatt tgtattcctc 80640
atattgcctg attccttgtt aatttccttt accactttgg tctgccttaa ttgcatccta 80700
tattctctga tatcatgtcc aaagttgcca catgatttac aaaatactgg tttccattca 80760
tatctaacct ctttatcaat gatcactcca cattcattct caaacatcac catatctcga 80820
tacatctggt ttggttctac ttcaaccaga attcttgcat attgcaacct ctccttttgt 80880
gttgttgttc tgtccgcttt cagaggatta ccaatcattc ctgctatttt tgttagagta 80940
ttttgtcccc aatatttgat atccaggttc atcaatctaa tccatacagg aattttatca 81000
actacctgct tatcaagtct aataacatgt ctccatggtt taaccacaat tggttttttg 81060
tcgaatattc taattccttc ctccaccacc ttctccttat tctccattga gtggaatctt 81120
actatgaata tacccctgat tacctgagct attttatcta ttcccagtgc tcccccaact 81180
cttttgaagt agccctccat aactgtttgt ggtggatttg aacccagcac gtaacaaatt 81240
acagcagatc tccagtagat tatctcatct tttatgtctc ccattgtatt tttcacattt 81300
tccctcgatt gctccccttc ctttctggtt aggttatacc tttcactccg ttctcctttc 81360
cttacaattc tactccaatt ttccccttct gtctgtgcct ttgcatggct ttgttttcct 81420
actaattcag attcactttc ctcttcaacc cattatttaa ggttaataaa tatggagcac 81480
tttatattct attaaatatt atatcccata agagaattcc aaatatttct agataatatt 81540
tttttaaaaa ttcatataaa atcttaaaag tatatataaa aattatatat ttatatgtcg 81600
gtttggttcg gattttttta ctcaatacca aaccaaatca aaccaaacct agtcgagttt 81660
tttttaatcg atttggcttg acttttcggt ttggtacggt tttttcggtt cagtttatac 81720
acccataatt ggagataata tacgttttgc aaaatgtaag tgcatagttg aaacttcggg 81780
ataaattgag gagatattta tgtgttatct ctaatttttc gaaagcattt ctttaggatt 81840
cgtttgtcca taaaaaaaat tctttttttc gaaatgtgtt aatccataaa tttttgaaaa 81900
attttctaaa atgagttttt gaaaattcaa aatttagaag aaaaaaacat ttttctccat 81960
ccactaacag aattacaata ttttttctag tgaaatacat gtccaagtgt atttcaaatt 82020
ttaaatatta tattttttca aaaattataa tttttatgta caaacgccta cttagaaaaa 82080
gtgtagccgt ttttctcttt atctacctag aagaattgaa atttgaggaa atatcacact 82140
actagaaatt gggcaaaaac cgaccattgt cgaccgatca attttggtcg gtcaaaaaac 82200
cggccaaaaa aagatcaaag ttggtcggtt tttaaaaata ttttatttta attttttttt 82260
tttacgaaat caaccaactt tggtcagttt tctttggcgc aaaaatgcga aaaactattt 82320
ttgagtcccg cgaaatttat ttttcaagaa gccgaccaac tttggtcgat ttttttattt 82380
aaaataaatt aaatttaata ttaaaaaacc gaccgaaatc ggtcgattaa tttggttggc 82440
cattttaaaa aaccgaccaa ctttggttgg taattttatt ttttaataaa atcgacctac 82500
tttggtcggt tattttcgtg cgaaaataca attaaagagt ataaatgaaa taaaaggcag 82560
tcttaaaaca aaatgcacca atggtctagt ggtagaatag tatccttcca cagtacatac 82620
cctggttcga ttcctaaatg gtgtattttt taattatata attaaaatac cgatcaatat 82680
tggtcggttt tttcggcaat ttatttttga atttaactga ccgaccactt tggtcggtat 82740
acccttccga ccttcaaaat accgtccata cgtaaatggt cgcgttttgg acggttattg 82800
gccattaccg accaactttg tttgattttt ttggatgatt ttgcccggat ttctagtagt 82860
gtgagtagta catatattaa acttaattgg tcaaacatga agaaggatga ttgtatgtga 82920
gtggtgatat atttaataaa gagtatgaag ttacactagt aaactcagtc atagtttttg 82980
ggcattcaca tgcaataact ttttaatagc atatcattgt ttgtagggcg gagtcacaat 83040
gttgtttgca ggttcggatg aatccactag tttttattca aatcttgtat ttatgttaag 83100
aaattcaata aatatgtaca aatcattaat ttaaaaccca gtaacttaaa aggattataa 83160
tcttgaaccc ataaggttca aatcctagtt ccgcatatga ttgtttgtta tgcaagaacg 83220
attacaacac cttaaaatta cacccacaaa aagaaaatat tttttttcct tcaagcttag 83280
gtcttggact gtgtccttta aatggatggg tagcaatagc aacaggttgc aattatagac 83340
gaatttagga tttaaatttt ataagttcaa cttttattgt ttatcgtatt tagcccatca 83400
tatttttaaa attatgagtt catatttact attttcataa ttttgatgga cacaaattta 83460
tactctgtat cagaagtgct aggttcagtt gaatcaagct ctcctatgtt gtatccaccc 83520
tggctgcaaa acaaattaat gaaattgaaa atcaagcact taaggatgta acctagcggt 83580
taatgaagta tcgagatttc agttcaaatc tcaacaaatc atttcaatta tttgtggaca 83640
gagttatttg atatttatgt tggaggtgaa aaatagtagg tatatcgtga aattagttga 83700
gagatgtgca aactgatcgg acaccatatt tataaaaaaa ttgaaaggta attaaaaaga 83760
aaaaactaat aaataaataa aatgcataag gagagagact gcattaggtg tatccctaag 83820
cgaggacact aacccttgtc ttacgggtct tggggtaatt ttattcttaa catttaggga 83880
cagattggaa gaaaaatctt gattcctaag gaattttcac tctctctctc tccctttgtg 83940
cgtatctaat aatttcttat ttaattcttt ctctctctct ctctcaaatg catgaacaac 84000
agatttgact gaatttatta ttattatttt ttaggttttt tattcggtgt ctggtatccg 84060
tattgagatt cgactaaatt cgaatttatg cttataaatt tcatattacg ggtaaaacgc 84120
tctctaataa aggagattat aaatatagaa ttcgaaatcg agacctctag ttaaggatga 84180
aagagtaatt actcaatcac tccaccacaa tccttgtcgg taagtattgt ttcaagtgag 84240
agtgaaaact tcattttaaa aaatcctttt tctcaattct ttattttttt ttcttttttt 84300
agcagaggaa tacaaaaagt atatcattct ttcacttgtc ttagaatctc agtttcgttc 84360
tttgtccttt gtatgataat gcttatataa atactatctc gtatcaagct agacaatggc 84420
taaatataga ctcatcgatc gaatgtaagg tacaaaaata ctaatgaagt ttttttgatt 84480
gaatttgaaa actggtggaa gaaacaaatt ttactttctc ttgaaaattt cccaaatcta 84540
tcttcttatt tttgtttact agaatatgat ttttggaatt tattgaccac ctttcggaat 84600
aaagaacaat aacaaaacaa gtgtaattcc aagagtggat ctgggaaggg tagtgagtac 84660
ggagacttta ttcctacgtt gagaaaatag agagattgtt ctcgataaac ccttgacaca 84720
agaaaagatg caaaaagaaa tggtagcatt cgatagtaac atcaacaaaa taacaagaaa 84780
acaaaagtga aagaaacaac atgcaataat agaaaatctt gaaaaataaa gaaaccaaac 84840
taaaaacatt tccaagaggg gggaaaaaaa ggaagcaaaa tgaaacactt cagtacctta 84900
caataatatt aaattgaagc aaactggaac cttagtttct ttatttttgt tcaatgtatt 84960
agatatttga tttatgattc ccatttgatt tatttttttt ggtcattcca atttgatcaa 85020
cttgacattt aaccgcactt tggttctagg ctaatttcat agatgcctct tccaaagatg 85080
attacttaca ccttgtttgg acggttacca atcgttttat aatgtattgt attgtgttgt 85140
attgtattgt attgtattgt attgtattgt attgtattgt attgtattgt atcgttttat 85200
aattaaatac aatgtttgga tagattgtat tgtttgcgat tgttaaataa tattttgctg 85260
tttgatttga ctgtaccgta ttgtactgta actgataagt ttactaaaat accctcaatt 85320
gtttaaatat taaatttatc aagaattaaa aataatttta aaaaatccct ttctactaat 85380
ttatcaccaa atatgtctta taaatagatt aagcaattaa attcatgcaa attctaacaa 85440
aattagcaat tttacgttgg agttggaagc gtaagaagtt cttgaaaaaa gggacgaaga 85500
caaagtatgt tataggttgg agattttgag ttaaaataaa aaaaaggtaa acggtaaaaa 85560
tagaattatg aaataataag ttaggacata actagaaaga aaaatagaaa acaatctcac 85620
cacatcaaat cagttgtttc aaaaaataag actttttatt gttccggaac aattgattta 85680
acaatacaat acaatcaatt ttaataaaat aatcaaaaca aacattattt tgagataata 85740
atacaatacg atacaactag taacaaccat ccaaacagca gttagttaga tatatatcta 85800
gtcgaaagtg tactttttca ctatgcatga gaattataat gttttcaatt gttaaatcca 85860
ttcattacca aattagctga attaggtcat gattgtctaa ttaattagtt aattcgatgc 85920
acaccaacta gatgtggcac gtagtcacat ataggtggtc caatgaatgt gactatgcac 85980
ccattagaaa aatatgaaat taaatcctta aacctcatta taaatacaag ataagagata 86040
tcgatctgta aactctcatt caattcccaa gtatttgaaa aaatgttttt gcacattttc 86100
accttctcct tttaatattt cagactttca gttaggtaat atatgtttta tgtgattgat 86160
atctgcaatt tgttttccaa ttgtatgagc atatgaagct ctgcagtagt ttaagacaaa 86220
gaatatttat tcatagttgg tgtttatatc aaattaagtt aatttaacaa ttaaaattaa 86280
agtgagaaac acatcacata acgatagtta aatgaaacaa tgtatgtgca aaatatatct 86340
ttttttctgg gcttggtgtt aatatcatgg gcaaacaaga ctactaacac ttatgagtgt 86400
gatgggataa atagaatttt catattccta attagaagtc tcgagtccga gctttagcat 86460
cgctttccct ttaataagct atacttgacg tgaatccaca tggatacctg atatttcggc 86520
cagttatttt ataaaattta caccacaccg atttttcggt tattctatta tgtataacca 86580
aagttagact tttcgaaacc gtctcaatca tgtcggtttc tcttcggtat cggtacgatt 86640
tggttaattt tcggtatttt cttaatgtca tataaaaatc gctaatagaa gtagaataaa 86700
ataacatacg tacttttata gaacttagca atattctatc actactagaa attcggcaaa 86760
aaccgaccaa ggtcgaccga ccaactttgg tcggtaaaaa aaacgaccaa aaaatcgacc 86820
aaagttggtc ggtttttcaa aatatttttt ttttttttcg aaaccgacca actttnnnnn 86880
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 86940
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 87000
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 87060
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 87120
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 87180
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 87240
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 87300
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 87360
nnnnnnnntt acataattaa aataccgacc aactttggtc ggtttttttt gtaatatttt 87420
ttttttgaat ttaattgacc gaccaaagtt ggtcggtaat tttcgaccaa ctattccttt 87480
ccgaccacaa aaataccgtc cacacgtaaa tggtcgcatt ttggtcggtt tttggccatt 87540
accgaccaat gttggtcggt ttttttggtc gatttttacc gaatttctag tagtgtatag 87600
atatttttac tatttaaagg atgatgaatt aagaaaacat gaaagatggc tagagtataa 87660
gtccatcaac tattctacaa catcgtaaac gaaactaaca aaagacaaaa aaaatataaa 87720
tcacacgagt aaaaagatat taatcaagcg gggcctcaag aataaagtca atacaagatt 87780
aaatattcaa aaagataaat ctaaattaca cgaaagaaac atattcaata ctttcttttt 87840
cacatgtaaa tttattcggc acggtttatt attttttcgg tttatttacg taaaataaaa 87900
aacctacctt aattatcgtt acatttataa atttatataa aacactacaa ttttattaca 87960
agaaacctaa aaatcgattt ggtctggtac agttcggttg gtttagttgt ttttataccg 88020
aataaaaaat caaaaaataa aggggagagt ttgggggggg aggggggggg gggttgatga 88080
cccaaaaatg tcatctttaa tttaaacgtt catttctatg ttccatgaag atgttgagag 88140
cttacctgct atgagttatg tatcacctga atagttgata ttaatgacgt tccttttcta 88200
gtaatacatt gcttatgatg ccactgtcag tattattttc atgttgtgtt acattgattg 88260
gactatgtat gtgatgttag gattggtttc tgagattctc tggcaggtgg ataggcaaag 88320
ttacaaagga aactctagcg aaaattttga aaattttggg agttagtaaa aattcgggaa 88380
attgaaatgg gtaaaagaag agataagtta tgttatgtac ttgaggacga actctacttc 88440
tcatttaagg actattaata ttatggatac caattggata tgataacaag tgtacggggc 88500
atgttataag tgatgtgagg tctaaggaaa gacctaagtc taagtcaagt aggaaaattt 88560
cataatagac taaagtttca aatggatacg cacaagacca aattttgaac gagcatatat 88620
atatctgtat ataaagaatt atgtgatgat ctacctatca aattaaaggt cttcgagtct 88680
agtttctaac tcttcaaacc gttcgtcatt tggacactcc tacaggaagt tatgactaaa 88740
ttatcaaaga ttgaaaatat acgattttgc gacctattct gcgatcgcag aaaagttatg 88800
cgatcgcgaa actgcttctg cgatcgcaaa ctggtggcag aatagaccag aacagtccag 88860
ttctggatag caatttttgt aaccattgtg cggcccgcat accgattctg cagtccatta 88920
tgcgaccgca tacccgattt cggagggtta atttttctat tttcataact cgatcccatt 88980
ttgataaata ggctttgggg cttattttgg ggcaattatc tgatgatttt agagagaatt 89040
tagagtgttt tagagagagg aagaagctca agtgctttgt tcatcaaaaa tcttgttcaa 89100
gctttgaaat ccaataagga attatcacaa gatcttcacg caagaggtaa ggttctaacc 89160
cctattcttc aatttcgagt ttgggtaaag atgggtgatt gtgagtgtga ttcttgcatg 89220
tgagagtatt agttatacat gcttttacca ataaggttat gggaagattg ttgagttcaa 89280
atgggtaaag attagattgg aaatggtaga aatcttcaaa caaaacttta attgaggatt 89340
ttaaagccaa tccgatgtcg gaattcgata atgtttgtat ggttgaactc gtatctgaac 89400
gggtgttcag atttcgcgag tttttccggg atttgagatg tgggtaccat tgttattttt 89460
aaaattaatt ttggattttt atctgaaaaa tttataaatt catatggaat taattcctac 89520
gttttgtatt gagtgtattg aattctttat gactagattt gaggattttg tacatgaatt 89580
cgtgaggtaa gggtttatta gattcttgaa tttggttgca aagcgaggta agtatcgtgg 89640
ttaaccttga cttgagggag taggacttat ttgtctattt gctacatgat ttaatatgcg 89700
ggtacaatat atatgtgagg tgacgagtac ttatgtgtta tttactatga ataattgcct 89760
atttaattaa gatattcttt tttaagttta ttattgatta tttgatcatt attcgtgaaa 89820
ttattattca tttaattata gttgaatatt ttggaatgtg aagtcggtat tctggtattg 89880
aattgattga taagtgcata tcctcgcatt taaatactct tccaaattta tattattatt 89940
ttcatggtaa ggaagagtgt aaaagcacga agggtgatgc cgtacaattt ttattattta 90000
taatattatt gtcatggtaa gaaagagtgt aaaagcacga agggtgttgc cgtgccattt 90060
gtgagggtaa aagcacgaag ggtgttgccg taccatttgt gagtgtaaaa gcacgaaggg 90120
tgatgacgtg tcatgttcag aaagtgtaaa agcacgaagg gtgattccgt gctaaatgag 90180
agtaaaagca cgaaggatgg tgccatgcca ttttcatatt atcaattgct cattttattg 90240
ttgattaatt aaatggttgc taagtgatac ttctcgtgct gaaattatta tatcgtttcc 90300
cttcgcatgt cccctcccaa tttataaatt attatttatt atattattgt tactttgtat 90360
ttgtatatac ttgtacgggt ggtttacgta tgtgtcttgt catagtctcg tcactacttc 90420
gtcgaggtta ggctcgatac ttaccagtac atgtggtagg ttgtactgat actacactct 90480
gcacttttgt gcatattttg gagttggtca cagcggcgta caatagactt gctcggattc 90540
aactacccag aggagacttg aggtataact gcacatcgtc cgtagttctg aagtcccctt 90600
ctatgttagc ttagctgtgt cttatctttc aaacagcttg aattttattc agacctttat 90660
ttgtattatc cgagtagctc gtgcacttgt gataccggat tcggggatat attttttaat 90720
tcggtattta tggtcttttg tactttaatt tagtaatttg acttctattt aattaaactt 90780
gcttagaaat agtcaagatt attttaacgt tggcttgcct agcaagtgaa atgttatgca 90840
ccatcatgat cctgaaggtg ggaattttgg gtcgtgacag ttggtatcaa agcactaggt 90900
tacataggtc tcacgaggta caagcaagct tagtagagtc tgaaggatcg gtacggagat 90960
gtctgtactt atctttcaga ggctataaag tttaggaaca atatcacttc tttcttattc 91020
tgtcatgtga tcttattcta tcatcgataa ttgaaccatt ttattcttat tctcttgaag 91080
atggtgagaa cacgtaatac atctaccgaa agacagggac cagagcccac ggtggcaact 91140
atgaccaggg gtagaggtcg aggccgaggt cgtgctagag gccgaggcaa aagcagaggt 91200
aaagctcagt ctagagctct agcagcaaca cttgttgtag aacctcagat agatctttag 91260
gaggatgttc ccattcagac tgtaccggtt ggaccagttc aggtcccgga aggatttata 91320
gctacttagt gcttcaggat gctctagtcc gtttggtaag tcttatggag ggtgtggccc 91380
agaatggtac atttcccgtg gcaccagccg tttcacaggc tgggggagga gcataaactc 91440
ccactattcc cactccggag caaatggctc cccagaatca ggctccacca ttcctgccag 91500
ttggggtagt tcaaccagtt gttgcggcac agaccgatga taggcgcgcc atgtcttctg 91560
aggccttatt gagactagat aagtttacta agctctttcc agttcacttc agtggaacac 91620
cttctgagga cccacgggat tatcttgacc gttgccatga ggtactgtgg aacatgggta 91680
tagtttagac caatggggtc gaattttctg tatttcaaat gactggttcc gccaagaggt 91740
ggtggagaga ttatacattg accagaccag ttggatcgcc tgcattgacc tgggagcagt 91800
tttaacggcg aattctaaag aaattcctcc ctatcacatt gagagaggat tatcacaggc 91860
aatttgagcg tctacagcag ggcagtatga ctgttactca ttatgagtcc cgttttgtgg 91920
atttagcccg ttatgctctc cttttactac ctactaaggg agagagagtg cggaggttta 91980
ttgagggact tacttaccct attaggcttc agatggctaa ggagaccgaa agtgagattt 92040
cttttcaggc ggctgctaat gttgctttga ggatcgagat agttcttgca caggagaaag 92100
ggcaggggtc tgataagagg cctcgtcagt ttggtgggtt cagtggtgcc tcgtctgtag 92160
gcagggctaa ttttggtagg ggtcatcctc ccaggccatt tcattcagca ctccaggcat 92220
cctacagtgc accaccagct cctatcagtg cacctccgat ccagagtttt caaggtggtt 92280
actcaggtcg acaaggacaa tttcagggtc agcagtcata acagccgagg tcttgttata 92340
cttgtggtga tccgagacac attgctagat tctgccccag gtctcagggc agcatgcaac 92400
aacagggctc tcgtgttatg attccagcac cggttgcttc accgcctgct cagccagcta 92460
gaggtagggg ccaggcagct agaggtggag gtcagaccat tagaggtgga ggtcaggccg 92520
ttagaggtag aggccgtccc agtgacgcag ttcagagtgg tggggcccac ccccaatttt 92580
atgcttttcc agctaggcct gaggccgagt catctgatgt tgtgatcaca agtattattc 92640
cagtttgcca tagagatact tcagttctat ttgatctagg atctacttat tcttatgtgt 92700
cctcttattt tgctttgtat ttggttgtgc ctcgtgattc tctgagtgct tctatgtgtg 92760
tatctacacc ggtgggagac tattgtagta gaccatgtct atcgtttatg tgtggttact 92820
attggtagtc ttgagactat tgtgactctt ttacttcttg atatggtaga ttttgatatc 92880
attttaggta tggattgact gccaccttat tatgctatat tggattatca tgccaagacg 92940
gtgaccctag ccatgccggg gttaccttgg ttagagtgga aaagaactcc tggtcattct 93000
accagcaagg ttatttctta tatgaaggct cgacgtatgg tcgagaaagg gtgtctagcc 93060
tattcggctt atattcgcga tcccagtgcg aatgttcctt ctatggactc agtacgagta 93120
gttcgtgaat tttcagaagt atttcctgca gatttttagg ggatgccacc cgacagagat 93180
attgacttct tattgattta gctcccggca ctaaacccat ttctatccta tcataccgta 93240
tggccccgcc ggagttgaaa gaattgaagg agcagttaca ggacttgctt gatcagggat 93300
tcattagacc caatgtctca tcctggggtg cacctgtgtt atttgtaaag aagaaagatg 93360
gttcaacgag aatatgtata gattatcggc agttgaacaa ggctactatc aagaacaagt 93420
aaacactgcc aagaattgat gacttattcg atcagcttca gggtgacaag gtgttttcaa 93480
agatcgactt gagatctggt taccatcagt tgaagattag ggcatctgat gtccctaaga 93540
cagcttttca gactctgtat gggcattacg aattcctagt gatgtcattt gggttgacaa 93600
atgccccagt agcatttatg aattttatga atcgagtgtt caagccttat ttggattcgt 93660
ttgtggtcgt attcattgat gatatcttaa tttactccag cagtcgagag gagcatgaga 93720
atcatccccg gagtgtgctt cagactttga agaataatta gtcatatgct aaattttcac 93780
aatgcgagtt ttgattaaac tcagttgcct tttgggggca tgttgtatcg gtagaaggca 93840
taaagatgga tcctaataag attgaggatg ttcagaattg gcctagacct acttcagtta 93900
tagagattcg gagtttccta ggtttggcag gttattatcg tcgattcgta gagggctttt 93960
catctatagc aagcccattg acgagactga cccagaaagg tatcccattc agatggtcag 94020
acgagtgtga gttgaacttt tagaagctca agacttcttt gactacggcg ccagtgttgg 94080
tattatccac aggttcagga tcttatacgg tgtattatga tgcatctcgc gttgggcttg 94140
gtgtagtatt gatgcaagat ggttgggtga ttgcatatgc gtcgcgacaa ttgaaagttc 94200
acgagaagaa ttatcatgtt catgacttag aattggcagt cattgttcac gcgcagaaga 94260
tttggaggca ttacctctac ggtgtctcgt gtgaggtatt tactgatcat cgtagccttc 94320
agtatctgtt caaacaaaaa tatctcaatt tgaggcagag aagatggttg gagttattga 94380
aagactatga tatcactatt ttgtatcacc tcgaaaaagc taatgtgatg gccgatgctt 94440
tgagtagaaa ggttgtgagt atgagcatgc ttgcttatat tccgattggt gagagactgt 94500
tagttgtaga tgtccaaact ttggctaatc agttcatgag gttagatgtt ccagagccaa 94560
gtcgggtttt agcttgcaca gtcgctcggt cttctttata tgagcgcatg agagggcggc 94620
agtatgatga tcctcattta cttgacctca aggacatagt gcgacacggt gatgccaaac 94680
aggttgttat gggggaagat agagtactgc aaatgcaggg tcgtatttgt gtgcctaatg 94740
tggatgggct tcgtgaatca atctaggaag aggcccatag ttccaggtat tatattcatc 94800
caggtgccgc caaaatgtat caagaattgt ggaaacatta ttggcggagg agaatgaaga 94860
aggatatagt tgcatatgta gcttggtgtc tgaattgtca gaaagttaag tacgagcatc 94920
agagacttga tggttttctt caaaagttag aaattcctga gtggaagtgg gagcacatca 94980
ctgtggactt tgttgttagg ctcccacgga ctcagagaaa gttctacgca atatgggtca 95040
ttgtggacag gttgaccaag tcagcacatt ttattccagt agcaattacc tattcttcag 95100
agtggttagc ggagatttac atccgcgaga ttgtacgcct tcatggtgtg cccgtgtcta 95160
tcatttcaga tcaaggtacg cagttcacct tgtacttctg gatggttgta caacatgagt 95220
taggcacgtg ggttgagttg agtataacgt ttcatccaca gacagacgga cattcagaac 95280
gcaccattca aatattagaa gatatgcttc gcgcttgtgt catagacttt ggaggttctt 95340
gggatcagtt cttgccactt gcggagtttg cttataataa tagctaccag tcgagcatta 95400
agatggctcc atatgaggca ttatacggaa aggcgatatt gttcgccagt tggatggttt 95460
gaaccgggag aggctcggtt gttaggtacc gatttggtac aggatgcctt tgataaggtt 95520
aaagttattc aagatcgact tcgcacaatt aggcaaaaga gttatgccga ccgtaaagtt 95580
catgatattg aattcatggt tagagaaaga gtattgtttc aggtttcacc tatgaaaggt 95640
gtaatgaggt tcggaaagaa gggcaagttg agccctaggt atataggacc cttcgaaatt 95700
cttgaaaggg tgggagaagt agcctacatg cttgcattac cacctagttt atcaacggtt 95760
catccggtgt tccatgtgtc tatgcaccaa aaatatcata gtgatccgtc ccatgtgtta 95820
gatttcagct cagtccaatt ggacaaggat ttgacttatg aggaggagcc ggtagctatt 95880
ctagcccggc aggtccaata gttgaggtct aagagttacc cttcagttcg ggttcaatgg 95940
agaggtcagc tgatggaggc agctacctgg gagtctaagt cggacataca gagcaaatat 96000
ccacatctct taaccagctc aggtactttt ctaatttcgt tcgaggacga acgtttgttt 96060
tagaggtgga gattgggatg acccaaaaat gtcatcttta atttaaacat tcatttctgt 96120
gttccatgaa gatgttgaga gcttacctgc tatgagttat gtatcacctg aatagttgat 96180
gttaatggcg ttccttttct agtaatatat tgcttatgat gccactgtta gtattgtttt 96240
catgttgtgt tacattgatt ggactatgtt tgtgatgtta ggattggttt ctgggattct 96300
ctggcaggtg gataggccca gttataaagg aaactctggc gaaattttgg aaaattttgg 96360
gggttagtaa aaattcggaa aattgaaatg ggtgaaaaaa gagataagtt atgttatgtg 96420
tttgggggcg gactctactt ctcatttgag gactattaat attatggata ccaattggat 96480
atgataacaa gcgtacaaag tatattataa gtgatgtgag gtctaaggag agcctaagtc 96540
taagtcaagt aggaaacttt cataatagac taaagtttca aatgggtacg cacaagaata 96600
aattttgaac gagcatatat acttgtatat aaagaattat gtgatgatct atctatcaaa 96660
taaaaggtct tcgagtctag tttctaactc tttaaattgt tcgtcatttg gacacaccta 96720
caagaagtta tgaccaaatt atcaaagact gaaaaaatac gattttgcga ccaattctgc 96780
gatcgcagaa aagttatacg atcgcgaaac tgcttttgcg accgcaaact ggtcgcagaa 96840
tggacccgaa caacccagtt ttagggacca atttttgtga ccattgtgcg gcccgcatac 96900
ccattctgcg gtccattatg cgatcgcaga cccgatttcg gagggttaat tttcctataa 96960
aaaagatttc ataacccgat cccattttga taaataggct ttggggctta ttttggggca 97020
attatctgat aattttagag agaagttaga gtattttaga gagaggaaga atctcaagta 97080
ctttgttcat caaaaatctt gttcaagcct tgaaatccaa taaggaatta tcacaagatc 97140
ttcacccaag aggtaaggtt ctaaccccta ttcttcaatt tcgagtttgg gtaaagatgg 97200
gtgattgtga gtgtgattct tgcatgtgag agtattagtt atacatactt ttactaataa 97260
ggttatggga agattgttga gttcaaatgg gtaaagattg gattgaaaat ggtagaaatc 97320
ttcaaacaaa actttaattg aggattttaa agccaatccg atgtcggaat tcgataatgt 97380
ttgtatggtt gaactcgtat cggaacgagt gttcagattt tacggttttt ttgggattcg 97440
agatgtgggt cccactgtta tttttaaaat aaattttgga tttttatccg gaaattttat 97500
agattcatat ggaattaatt cctacagttt atattgaata tattgaattg tttatgacta 97560
gatctaagga ttttgggcac gaattcgcga ggcaaggatt tattggattc ttgaatttgg 97620
ttgcaaagcg aggtaagtgt cgtggttaac cttgacctga gggagtagga cttatttatc 97680
tatttgctac gtgatttaat gtgcgggtac aatgtatatg tgaggtgacg agtacttatg 97740
cgttgtggtt gagtcaaagc atgtaggtgg aatttgttta ctatgaataa ttgcctattt 97800
aattaagata ttcttgttta agtttattct tgattatttg atcactattc atgaaattat 97860
tattcattta attattgttg aatattttgg aaggtgaagt cggtattctg gtattgaatt 97920
aattgataag tgcatatcct cgcatttaaa tactcttcca aatttatctt attattttca 97980
tggtaaggaa gagtgtaaaa gcacgaagtg tgatgccgta ccatttttat tatttaaaat 98040
atcattgtca tggtaaggaa gaatgtaaaa gcacgaaggg tgttgccatg ctatttgtga 98100
gtgtaaaagc acgaagggtg ttgccatgct atttgtgagt gtaaaagcac gaagggtgtt 98160
gtcttgtcat ttgtgagtgt aaaagcacaa aggttgatgc cgtgtcattt tcagaaagtg 98220
taaaagcacg aagggtgatg ccgtgccaaa tgagagtaaa aacacaaagg gtggtgccgt 98280
gccattttca tattattaat tgctcatttt attgttgata aattaaatgg atgctaagtg 98340
atacttctcc tgctgaaatt attatatcgt tccccattgc atgtcccctc ccaatttata 98400
aattattatt tattgtatta ttattacttt gtatttgtat atacttgtac aagtggttta 98460
cgcacgtgtc ttgtcatagt ctcgtcacta cttcgtcgag gttaggctcg gcacttacca 98520
gtacatgggg tcggttgtac tgatactaca ctctgcactt cttgtgcata ttttggagtt 98580
ggtcccagtg gtgtaccata aacttgctcg gattcaacta cccaaaggag acttgaggta 98640
taactgcaca tcgtccgcag ttctcaagtc cccttctatc ttatcttaga tgtgtgttat 98700
ctttcaaaca acttaaattt tatttagact tttatttgta ttatcctagt agctcgtgca 98760
cttatgacac cagattcagg gatgtatttt gataattcag tatttatggt ctttcgcact 98820
ttatttcagt aatttgactt ctatttaatc aaatttgctt agaaatagtc aagattattt 98880
taaccttggt ttggttagca agtgaaatgt taggcgccat cacgattctg aaggtggaat 98940
tttgggtcgt gacaagggga gaggcaggcg gatctaggat ttttataaca tcggtgcacc 99000
attaaaaaaa ggtgaataga ggaagtatta agtgagattt actccttggt cctctaggta 99060
aataactaaa tattcaatca agtgcaccgt ataacctcta caaatccgcc cctgggtggg 99120
ggaggattgg aggtgtggag acaagggggt gattattatc tcgaaggatg taaaaactca 99180
acagtaaagt ttgaccgtca agaaagggaa tcaaaagacg gtaaaaaaac acatggcatt 99240
gccaacccta ttaggtttta tttcttgttt attaaatact ttaatttaat ttttctgttt 99300
gttgtgatcc attattaaaa ggctgcctat tgtatcccta cagtaaaaaa aaatatatta 99360
tattaaataa atgcgtctcg gtaatataat cataatcatg cctcaaactt tgcctttgcc 99420
tttccctcca tgtgtaaata gggttgagag gaaattatga cttttgaccc ctatatcgtt 99480
tgactaaccc tagtttcgtt tgaatagtaa tttccnatat atatatatca cgctctttgg 99540
gatgcaatcc tttttcgaat ctgtatgaac gtgaaatatc ttgtacattt ggctgatctt 99600
tatttcctca tgaccaaata gaatgtctta tataagagaa gatccatttt atgatttatt 99660
gcaaatgtta ttcagttata tataattttc ttgaaagaga attggtgaat aaaacattga 99720
aaaaccttat aaagtaattc cattttattc aaaattgtaa attggccata cgaaatcatt 99780
ttcttcgaga ttagtaactg tttttacgac tcaaactcgt aagctataga tcacacaaaa 99840
atattttatt gttgctcagt ttccctttaa gaaataatgt cgagtttata ttatcttata 99900
atttgccctt tttacaacca ccttatgaag atgttatttt tctcccgttt ttacgctgtt 99960
ttaaaggtcg gttaattaaa ttaaaaatta cggaatacta gtctactagg attagtatat 100020
atttatttag ggggtgtgca tacgtacaaa tgttagtaat aaattattta ctgtcactgc 100080
agaatatatt gaaactggat tctattattc aaacatctct gactgagtgt atccaagtgt 100140
cttttccttc cttttctttt gtttattgtt tttttttcct tagtatatta atccacgtgt 100200
acctaattgc aacatgttcg agcatcaaat aattatagga aaaaactgac acgctgatat 100260
gagaattctt tcaacccctt tcctcttata ttaatgctcc gatcatgcgc atttgctatt 100320
atggcctaaa gtcaaaaata ttaaatttaa agagattaaa tgtctactaa acaggcttac 100380
caaattggta tcattattct atctgccatt gaaagagctg tagaattaga ttcagcaaaa 100440
gtaaaaattt aaataacacc ccatgttcca accaaataaa tgaatgaaaa tgttttaaat 100500
caaatataag ctgtagattt tcatttttca ggaatccaaa ttttatccct acttagtcca 100560
aatcccaggt tcattaataa tcgtcttatc atatggttca gtaatttata tgttggtcta 100620
aacgacctga cctctttaaa gtaggactat ttgataccag ggacggagct agagtgcgag 100680
aaacgagttc gaccgaatcc aatagctttg tttcgaatct tgcatttgtc ttaaaaaatt 100740
catttaaaat gtataaatta ttaatttgaa actcactaac ttaaaacgat tgaaatgacg 100800
aacccattag tttgaaatcc tagattcacc tttatttgat acataatatt gcaactaagg 100860
atgcagtcta acaatcaaat aaaatggata aatatgtgaa atatgagttc agatccgagt 100920
aaaataagaa aaatactatt tttttctttc ccattttatg tgacaaaact tttatttttt 100980
gtttgtccta gtaagagtga catcttttta tttaaaaata atttaacttt aaacttctca 101040
cgttatactt aacgataatt ttttttttta ataaccacgt aattaaatat ctatgacgta 101100
tcctcgacac aattctcggt agggtttgtt ttcttgctta aactccggtc aaatactgtc 101160
acataaattg agacaggaaa taggtgattt cttcctattc tggtggaggt aacaattatc 101220
tgatagataa ttgaggcgcg cacaaactga acgctaacac ttattgaagt ctgatgtacc 101280
tggctatata cagtgcgttc agataggcca tatctacccc catgaggaat aaaaaccgat 101340
gatagtatga ataaatgact ttaaggtgta tgtgtgtgta cagtcaatta attctcagct 101400
gtgtgatgag tcgtcttttt ctcttcattc tctaggctca actctgtaaa gtagtgtgat 101460
atatatatat atacacacac actgtcaatg acccatgtga aaacattaac ccttttcttc 101520
ccaacttgtt tggtgtatat ggttataacc ttagatcaga aaaatggccc cctcttcata 101580
tgaccattca atattatgcc atgcaaaatg cagcagcata ttcagataat aacaggatta 101640
aaaaaaaaac atcagcagca tgtcctccac ggacattcag ctgacgtggg tccggctcta 101700
tgcagtggcc aacgtaagaa aattcaataa gagactaata ggctatatga aagagtgttc 101760
aaagtcaatt ttttgatcaa taataagtac taatatttta ccttataaac aatataattt 101820
tttggtgaag aatattcagt tgaccaccct cgacatgaca tagtttcaat tcgcccatgc 101880
ctgcatgcag aggcggagct agcttatagt gtgcaggttc agccgaacac atttactttc 101940
gcttaaacgt ggtatttata ctaggaaatt cattcaacat atataaatat tttattgcga 102000
acacaataac taagaagagc tatatgctcg gtggtgggtt cggtggtaca ttcagaaacc 102060
ataaatgtca aattctggcg cctttgcggc tcttcatgca gcctaggata ccactcaata 102120
cttgtaaatt taggtgagtc aaatggactg gagatggaga aaagcttggc caaagcgaga 102180
atattcctat acattaagag cccgtttgga cataaaattt gattgaagtt ttttttcaaa 102240
aaaattcatt ttttttcgaa atcagcgttt gttcataaaa tttccaattt ttcacttgaa 102300
gatgcatttt gaaattttta aaaatttgaa aaactccaaa aaactgtttt tcataatttt 102360
cacttaaatc actcacaaaa cttaaaaaac aacccaaact gaaatttatg tccaaacaca 102420
actctaaatt tcaaatatca ttttcactta aaaaaaaaat ttcaccattt tttcgaattt 102480
tacaattctt atgtccaaac gcctactaag aatatctttg agttgaccga gcaacacaat 102540
cagtgcaatt ttttattcat attaaaggaa aaatggttaa attttctata aaattttctc 102600
aattgatttt aaaggatgaa aattgaagtc atggccagag ctaaaactgg tgagcatatt 102660
tgaatccatt cgcatttaag agctatatat tgatttacta ctaatatttt tgaagaactt 102720
aaacttatta actgaaagag agtcgaaggt gaagtcttct tctgcgaata accgaaaaga 102780
tacaaaggaa ttaaatccta gactagttat cacatcctag ttatagataa tgttttatat 102840
ttttcttcat taacctttct tgcgagatga gactaaacat attgttagat attttatatg 102900
cattattttt ttattaggtg agcagaataa tgtaagcttg cagcttttaa caaaattagt 102960
taattattat tcctctaaat ctttgcacaa taatctgtgt tattattcgc agcctgatat 103020
taatacatgt ttttagttta ccgcatggca tgtattatgt acaatcatta gttcgtgaac 103080
caacaacctc taagtgaata cgcacgagag aaatttatac tctccagtca caatttacgt 103140
ggcattattc ggattttaag agtaaaataa atttttcttt gactgtgata ttttgatata 103200
cattttaaat atttgaatta ttaattattt caacttatag tactcgtttt aagtagtttt 103260
caaatatata atttatctca aaaaattata agattttata tctgaattta cggccaaaaa 103320
aagtttaact cgcgaaattc gaacaatgcc acatcaattg gcatagaggt agtatatgct 103380
ttacaattat atatccaatt gtacacatac aaaatttcat caaagatatg aaactactaa 103440
tacaacgaga gagcgaattc aaaagataaa ctttatgaga tcgagttcaa aattctactg 103500
tagttttatc taccggattc aaaatctact gcaaaaatat tagaattagc tacgaacttc 103560
gtcgctaatc tgtcactaaa ccactcgtac caagcaaaat atcttgataa tcttttgcta 103620
atccctttct aaatgagatt agcaacagat ttttctgttt agctacagaa tttatccgtc 103680
gctaaaactt gattttttag tagtttaatt atttttaaca catacaaaaa atttgagcta 103740
aagctagtga gttcaagtat aataaccata ctactaatac aatgtgagtt ctctataact 103800
gaatccttat ataacaacac tttactataa aaatcaagtt tttttaggaa ccaaatttca 103860
tgttctatta taatatatgt tttctataac accaatttat tataacattc aaaaatatct 103920
gaaacaaacg aaattgttat atagagattt gagtctagta ttatttatgc atgcacacat 103980
acacacacca aaattcaaat ctcagaaaga gacacataga agaaggaaca aaaaaaataa 104040
cctgtaaaat agtagtgggg aaatgggaac taggattttg catacattgg agaaataggc 104100
ggagcattcc tagcagcatc acccgtgcct tctcggtatc gtatattttc tgcaactatc 104160
cccaatttgc acggtctttt atgcaattca accatgaaac taaaccaaag cctctttttt 104220
tataattgtg ttaatcggac taatttatat gtacctcaac taacttcacg agctatcgtg 104280
tatgtccatt aaggcttgga ctgataagag aaatcagtta acgtgtttgc gttcgccctg 104340
aaatttgaac ttaaaacatt atggttgaca atttcacatc cttgttcacc aaaagcaaag 104400
ccttcttcca atcagatata atatacattt aatagtataa aacttatctg ctatcaatgt 104460
attttacata atttgtcgta gcaagttatc atttattttt tgaattatta attccactta 104520
tgatggcaaa aattatttac actttaatat catagaaaag ctaaactcga catatgagtt 104580
tacaagaacc aaatagattt tgtccagact ttgtttatac tttatatatt aaaatgttca 104640
ctaaatatct ataattattt ggcaatgtaa atccaatatt attgtaaatt tacttaaaat 104700
tgatataaaa actcataagt tataaattct ggattcgtct ttgctcccaa ccaactaccc 104760
tccacacata cacacacaaa gctcttatct tcttttccaa agaattaaat caatattaac 104820
tttgagggtc tttgtctttc ttcatatttg gttcaaaagg gttggaatcg aaaagataaa 104880
aacgtttcga aagaaggaaa ataaataaaa taaagcttac ttcatgctac gctttcctca 104940
aggtacccaa tgaagtgagg gtttaagata aaagcaacct acagatattt atcttttcag 105000
ttgaaatatg cctatgtacc agagcaaaaa cgatctactt tgaagtatat cgtttatcga 105060
tcaattagtc ttaaaaatta aattattctt tatgttctta aacatcttat ttaattaacg 105120
ctccattaat ttaaatagtg agtatatata gattaaagaa aaaaaatagc ttattctatc 105180
tctatcaaat taaattcact tttccaaaac gactaatact tgtgagaggg agtaaaaata 105240
agattgagag ttattatcta gcaatgtgaa aagtagggtt ttggatttaa aaaaaaaaag 105300
tagggttttg catggagggg agctagaaga gtgggatttg gactcatatt tacacttcca 105360
atggacaaat tacttaggaa aatgaaaaaa tcagatgagt ttaagttata tttatcgtca 105420
atataaaagt ttttactatt aagtcatctt tatatatata tanggagata ttattctgat 105480
actgtaaata aaaattttaa tttgacaatg tatataactt aaactcaaaa cggataacat 105540
gaaaaacaaa aatacataga aaaataaagt aatataaagc cagccacgcg tatctgtggc 105600
tgtctgtata tgaacccaaa tatcatctcg taagctaaca aaaatgccta ggaatgctca 105660
tttgtttctt tctctttctc tttttcttgg tttttgatgc tcttaatatt atgttataat 105720
tacaacttca agaaaatcaa acactgtttg ggattcaaac cctatgtttt gacctcaaca 105780
gtttgaccct tcttcctata tatatttcaa ccaaatcaag ttcttttgca ctcaacaaga 105840
gcaacaactt aaatacatgc aaccaaatta agataacagt agatcagaaa gaagttagaa 105900
ctgcagtaaa agggaaaaca acagcacata agaaattgta ccaaaaactt ttgactgcat 105960
attgttttgg aaggaagagt atgatttgta ttaaaatacc atattccaaa attttaatga 106020
ttggtggaaa gaaagaaaag gcaaaataaa gtaaaggaat ctataaagat tatggcagct 106080
aaatttggca cttggagcat gcacctaggc cagtctaaaa gagtgataaa aaggaaatta 106140
attttaaaaa aaaaacaatt gtcatctttt tccttaatat attgtattgt atggaaccct 106200
tgataattta aaaagctgat caaagattga cctttgagta taattcacca tattgtggaa 106260
agacaattta tattttgacc aaaaagggga aaaagaagtt ttataacaat gggttcataa 106320
cttcaaccta ggctccctac aaccaacatt gggctttggt ttggagtaat ttggacaaag 106380
tgcacaaaca accatttttg ggctgctatt taggggttaa ccaatatttt tatcctgaaa 106440
ttttgaatta caaatcttat tgttaggaca ttcttgtccc gaaaaattga ctgaaaaact 106500
aaaattcaag atgcattggc taatttctaa atatcagccc tttagagtgg ctacctagta 106560
tcatttctac gagcaattta attattctct agcccggaca tctcttagac cttcatttcc 106620
cataatgcag tcggtttttg gagaaatttg actccaatgc tgctgcattt tttgttgcaa 106680
aaatggggga tgaatagtgt cactccaaat ttggagcgac attattcatc tcctccattg 106740
ctattcccta taactttatt attattttta ttactgattg atctctttat atatacctaa 106800
ttatgtttat gtaatatctt tataatatta attttacatc ttaaatttgg tgtataattt 106860
tgataaatta atttttgtgc atttattatt tttatgtaaa attataagtt aattttatta 106920
taagttataa ttgtacaaaa aatatataat catctcaaaa aatgaatggt gtaaatataa 106980
aatattagat gttgctaaaa ttgaaaagta aaaattgaaa atacattaaa attgaaaata 107040
tattaaatta aaatacataa aaattaaaac tgcagtaaat agcataataa cttagtaggg 107100
acctatgtcg tttccagata caccaaaatt attataatat tgagtgaatg gggtcgagaa 107160
gtgctacatg atataataac tacatgtatt atactgcaca acatgataat cgagaatgcg 107220
cgtgatctta atgcaccaat tcaagatgat tgggaatgtc cacctccaat ggtagaaatg 107280
gtagaagatg aaatcaccga tttgaacaat ttttagctcg acacaaaaga attaaggaca 107340
aagatactca ttttacactt cgtgatgcat taatagatca tttatgggag catactagag 107400
gtgaaagttg aatatttatt tagtatttaa tctaaatttt accataatgt aatatgtatt 107460
taattatctt gtatctcaat gatttcactt ttatttgaat tattcgtgaa tatatatata 107520
tatatatata tatatatata tatatatata tataaaatct ataatatttt cttacaaatt 107580
atattattta aaaatttatg gtgtaaaata attttatatt aaatggttat ataagaaatg 107640
aatataaatt atatgtgatg aatatgtaaa aaagaaaaaa aagatagaat ttctttaata 107700
gaaataagaa aagaaaatct aaataaaaaa taataatatg atattgacga gagagaagaa 107760
tataaaatga aatatttttt ttggagtaaa aaatagaata gtggttggag taactttact 107820
ccattttgga ggagaaaata gaggcaaagg ttggagatgg ccttaacacc cctttatcca 107880
caatttaaaa aaaacatgca tttgtaaact tagcttaaga aataggtatc cattccttct 107940
aatgcatttt attagctaag ttgtagtggt taataaaggt tgcagatatt ttaagataat 108000
ttttcttcat atgagtttac ttgcaaaaga gattttcggt ttcgaaattg tcaattacaa 108060
aaagatgaat taaggaatgt taattaacag tgtacaatct gcgcaaacta ctcttttgtg 108120
acaaaatagg tgcaaaatat acctttcttt aaatgcaata ttaataatac acgagtttta 108180
tgttggatta tttattgtaa tacgtaatta caagctaaaa ggcaagctct aaggaccttt 108240
tatcttttat ttactgttac tcatgttcta tttcatattt tatctcgcac aacataatct 108300
atattatatt aaaagtacga agacacttag tgaaatgtcg ttcgcctttt ttatctttta 108360
aaaataaagg tcacactgga taaaatagtc atttgcttat ttttctaata ttaaaaaata 108420
gacatttaat taattcccta acatttagga gtttgtataa taaatttttt ccttatttga 108480
actgtattaa ctattatgac atttagaact ttaaaatcat taatatttta ccttatataa 108540
attttgcact taaattattt ataaataata aataaaataa ataaaggaga gaataagaac 108600
actaaagaaa gaggaagtgc gtttggcttt ggataacatg gaagtggtcc aatttgttaa 108660
cctttatacg ttctgattta tatgaaactc ttctatatta gaatatttaa aaatatatag 108720
aagtctattc cactaataat agtattctat attataattt tagttttcaa agcttttaaa 108780
ttagcaatta caattatttg gaatattgag cagaaatcaa taacaaactc caaaattatc 108840
aattattcca acaagataat ttatgaaatc ttttaacttc tctagattgt attaaattta 108900
gctgaatata agcgagtttc ttaactataa ttatggcttc taaaagggca tttgaattgt 108960
agactttatt tatgatataa agtgattctt aaatttttta gatttacaaa gaatttcatt 109020
tgcttttctt tggaacatgt catgcatgaa tgatttttca cctaatcggt tttttaatat 109080
ttgaaaaaga attcttatcg aataaaaata taattgcaat taaataccta aaatttggta 109140
tgatctagct aattaatatt atttaaatac taatctcact taaataatga tatttccaaa 109200
ttaaataaac acttcacatt ctaacttcgg tcattctttg aaatgcattt taagttgaat 109260
attgagtatt tttgtggagc ggtttcaatt tttattagtt atatagacca atattcatta 109320
tttttaagaa cttatatttt tattttataa ctcaaagata aattttaaat aattttttat 109380
tgagttaggt acacgcgcaa agcgcgtaca ctaagactag taggttttta tatacgtaaa 109440
tgtgatagta tcagtaacgt aaagtttaaa cctaaaaact aaatgataca ttagttatgc 109500
agaactatat aacgaaaata aaaaattatt taaattatgc ataattacat taataaggat 109560
tcattgacta gttttacgat ggtcatcaac ttaaccttaa taaatttgag ccaaaattat 109620
tttaccttat atcaccatcc aaacaatctt gggaaaatac catctatgtc catttataag 109680
tagcttatta caaaaattga tcaattgata aaatattact aatattagcc aattagctat 109740
ttgtagtcaa aaaggtcaat tttttgcttt cttttgagta agtgttacta gaatagattg 109800
catacatctt aaagagtttg aatcttagtt ttgagatgat ttggcgaagt tttggtgtgg 109860
tttggattga aaattcgaag tagatgatga aacatgaaaa aattatatgt gtatcacact 109920
atgcatcatt tgtgtatcac atatgtatca taattatatc aaatgtgtat cacgtgtata 109980
tccatatata cttgtgtgtg tgatacatgt ttgatacatg tgtcgcaaaa atattttttg 110040
acttgatttt aactacgaat tttgatacca aatcgcctcc aatcttcctc aaaatttgta 110100
tattgactca tctatatgtt ttcaatgaat ttcaaccata cccattgaaa aaagtccttt 110160
tgtgcttaga ttttttaaat tttgtatata tatatatata tatatatata tatatatata 110220
tttatcacct tatttgctac ttcatccatg aaattttctt tccgtcttgc atctaatgtt 110280
gctgatcaag tttaaaaata tgaaaggaga tctttgcgtg tgattcttgg agagaaagaa 110340
ccttacttat ttgggttttc aatttttata tgtgcttgac taatttttgt aagtttataa 110400
ttaatgacta gatgtttgta agttgaaact tatttgggac atttacgtaa gattcccaac 110460
aatcttgccc aattactttg ccctgcattt gggcctatac cagagaagcg aagtgcaccc 110520
atagccagtt ttagcatgct atttaaaata tatgtataat ttataatgta tttgatgatt 110580
aattaatttg tccaaacttc aggactaagt atcttgaatt ttttaactgc taatttaaaa 110640
ttcatgatgt agtgtcctaa atgtttgagc agctaatttg aaatttagga ccaagtatcc 110700
taaatttatg aattgctaat ttaaaattca tggcataaga tttggatttt tggacataat 110760
tttgaacttt aggatacggt gttatgagtt taaactttaa ggtttaaact tcaagacaaa 110820
gtgttaggtt taaacttcaa gacaaggtgt tctaaagttt gagcaaattg gctaatattt 110880
aaataaattg taaactatat atatatttta aaccgcatgc ttaaaaggct atacgaaacc 110940
ggaaccgacc cgacccgttg ctctctccac tcctcgatct ctttcaagga ggaggaggag 111000
gaggagtaga aagaaaaagg taaggtgaaa tgggtattca gaatccattc attttcttct 111060
ttttcttgtt cacattgcat agaagttcag ttgaatcttt gaataaagaa agagaggcaa 111120
tagaattaaa aggaggacca aaagatgtag catgggtggt tcaattatct gatcttcatt 111180
tcagtgttca tcatcctgaa agggccctta acttctcaaa tattgtgggt cccactcttt 111240
ccatgatcaa tccttctttg gtcttcatca ctggtgacct tactggttag tatacactct 111300
actttcccct aaattttcac taatattact ccctgtttaa aaatttcgtt cttacattct 111360
gttgatttga tattgggttt tatggatttt ctgtaaaata tagtccttta cccaaaaaaa 111420
aaatgatctt tttgtttctt gaaactgttg ggttggaagt tgaggtaggt gggttttttt 111480
tatggggtgg gggtgtaagg gggtagtagt ggatgttaaa acaagttgct caatttgctg 111540
gaagaaaaga tttgaatttt tatcaatgtg aagtagaaaa agaatttatg atgcatctgt 111600
gctggtggga ggtatgaggt gatcgctaaa atagtcgatg tgtgcacaag ctactccgta 111660
caccaccgtc attataaaaa aggctatgga ggcattttca tggaaaataa ggaaaaataa 111720
accaaaaatc tgttcttttt gtttcttaat actgttgggt cggaaactga gggtggtggg 111780
ggttgaatgc gttnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 111840
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 111900
nnnnnnnnnn nngagataag ggggtaggag tgggcgtcga aacaagttac gcaattaaaa 111960
gatgaatttt tatctgtatg aaaaattgac tgaaaagtta ctgcaggggt tcttttgttg 112020
ttgtcgggcc tcacactata acattaatga agggtatagt gcgagtatga tgctcagttt 112080
tacaaggcag caatgtttgc aaaatgttgc aatttaagat atgattgata caaaattaaa 112140
gtgtagttgc aaaagtagct tagttttgtt ttttgtctcc tttgtgtccc gtactctgtc 112200
aaatattaca cgaggtagtt ctagaattga aggtcaagtt ctgctattaa aagctatgtt 112260
ttgataatta tagttggttc agattgattt gtaagtcata attgagatca ttgaccactg 112320
gttagagttt ctgaactgct gtttaaggtt tatctctgat gttctggtgt cttactttgt 112380
gatataactg acctgtaaat tgttcagatg cttgttagat ataaagcatt tccaccctaa 112440
agtactttcc gacttgtcgg ttgctaatca tgttacagta aagcttttgt aaaagtacta 112500
tgagtttcag tgctcattgc tcttatacca ctgataattt gaactgttac tagatggaaa 112560
gagcaaggat ttactaacaa tgaaacaaga tgaagaggag tggctagaat accagaaagt 112620
ccttgaagat gtcactaaaa ggagtggact gaagaagaac atgttttatg atctccgagg 112680
aaatcatgat gctttcggtg tacccgcctt tgggggaaaa tttgattttt actcaaaata 112740
tagcattaac gggcagctaa aaagaagcgg actggtcaat agtgtcacta ttcaggtatc 112800
tgttacctta ttttgttgga tacacactct ttttcttaac ctttcaagct gacaataacc 112860
tttcaagtga aactaattgg aaaggaaaac caaaggagta gaaaagaggc ttgggaattt 112920
tccagaacag ggaacaaggt agagggaaat tttttaacat tggcaacgag gaagagtgta 112980
gaatccatgt aggggataaa catatctctg tattcaatat tttatgaatt ctattttggt 113040
acttgtcaca agattatata aaggaaaatc ttaacaatca aagaaattca tgaatgctat 113100
tataaagttt gacctaatct tcttttataa tcttttgatt ccgtgtgtta gaactttctc 113160
cttgttaatg taatctttcc aaacaaaacc actatcggtg taattattat tatgttatta 113220
agacacccgt agccttcaga atgaaggtga attatcactg aactttcata tagatcagtc 113280
agctaagcat cgattgcaaa cttcacaaac tatatgatgc cgtaatttga gttttttcac 113340
ttaatatctc atactgtctg cttcaacctc ttacgatgac tatttactct tatgatccag 113400
actggtgaac gcaatattct gttcgttgga tttgacagcg ctatgtcttt aggtcttcgg 113460
ggaccaacca atctatttgg tcatcccact gatcaactat tagatgattt aagctctgag 113520
ctctcggtac tagattctca acccgcaaaa tctgttatca agattgctta tgggcatttc 113580
ccactttcat tttctgcagc atcacgttct ggaagaaccc tgaagcatac atttctgacg 113640
cataacttgt cagcttactt atgtgggcat ctgcatacaa agtttggtaa gaatttaaag 113700
cggcgtcatg agtcaaatca acatcccttt tactctcaca atcttttcca gttgaatgga 113760
catggatcgc atctgggtaa ttcgaaaact tgttcagatg gggcaactga atttaaagag 113820
ttctgggagt gggaaatggg tgactggaga aaaagtagag caatgcgcat attggccatc 113880
gatagagggt ggacgtcttt tgttgatgtt gacttaagat tgggagctaa gaatgttatt 113940
atattgccaa catttcctct ggactctcgc tttactttgg agagatcgtt tcacaaatgc 114000
aagatggatc ctttatactt caacagtatt agagctcttg tattttcttc ttcgccgatt 114060
gtgtcagtcg tggctaggat ctacgactca agtcctggaa gtcttgttat agtgttggag 114120
actcctatga aaaaaagtgg ggatgcttca tctagggcgg acctttatac atgtccctgg 114180
aactttaaag cattcgaaga tccatctccc gatagatttt tgttgcaaat agaagcagtt 114240
gatattagag gcagatcaac tttgactgaa ctaaggccat tctctgttga cggtcttcgt 114300
gctaggcttt catggaattg gaaagagttc atggttatgg gttgtcagtg ggaggcttta 114360
tattacccca tattatggtc cttttatttg ttaactcttt ccgtccttct cgttccaaaa 114420
gctatctttt tattttctaa gaagcagtat acttacaaga atttcattag taataaagga 114480
gtggtgagtt gtgttgcgtg gattctatca gagctatata atattccact agcttggctc 114540
tcaatgattg tttacttgtt ttacctcatt ttatgtcctt ggctttctgg ccaagttttc 114600
accgaaggag gagaaagagg atacatgacc tacaggggtt gggtgctgag attgaacgag 114660
agggaaaagc tagactttca cggatatcca gatataatgg tgatcatttt tccccatctt 114720
tactttgtgg tgttgcctac agtaattgta attggggcgt tggtggctga gagagcaata 114780
ttccaagatc atcttcgagc tgtttctgca aaaaaggaag atgattattt ggtgacgaat 114840
aaggtatctg catctactaa tggtagaaat aagacgctga cactcctcca taggcgctgg 114900
attaggaaaa tacttttgtt aatttcttca gcaatttgtt ggaagcattt tttggtaagt 114960
tttcaactgt tcaatttgat gtccatcttt attctgattt aatgtgcctt tttcttactc 115020
aaaatgttta ttttccttaa aacactggag agttgtttcc tttccaagtt cccaccgtta 115080
aggctgcacc atcttttggg aactcatttg aaatcactta tatccttcag ataaactagt 115140
cagttctttt ccaaattatg gaaagtactt tcacaaagat aagaggaatg gtcaatatcc 115200
ttcgtattct tcttgtttag ttattcattt ttatgttaaa caaacatgat caacagaaga 115260
ggataaaggt tgtttaaaat atcctgtttc cagaatttta cattctgcca atgttttttt 115320
caacgaaaac tctcaccacc atcacatagt ttaggacttt ctgtcagata tcctcttact 115380
tttgtttatg tggaatacgc aacctcgtga ttgttccaac taagtggcaa tagcttcaat 115440
ttgtttccag tgaacataga taacgatact tttagagcat tgcaggataa tgtgtttcaa 115500
ggagatgttt caattctaag ttttccttgc tttaccttgc tcataattgt tcactaattc 115560
aacaatcgac ttcttgctaa ttttgttctt ttacgatgca gaactgcaga gctctgatca 115620
aagcttatgc aatgaaccca ttaatccatt tcccaatata tagcatgtcg attcctctct 115680
ttttggccta tactatctac aaaaccagca gagctgagta gaatttttgg aagtgaacta 115740
catgtaaagc cataagttta atgcagaagc ctgtgaaaca tacaccggct tattagtaaa 115800
gaaggcgtca acagattgca gctctcttta gtatctaaag catctcatga ggggcaatat 115860
gaaagcttca aattccagtt gatagaatag tggaagcata gaatgttctt tgttatagac 115920
atggaaatgc tggttactag aattcagtct ttatgtagtt ttacagtttt gttgaaaatg 115980
cagcatcgtg tttgcagcaa tgtagaactt cagatccatg taaaagtatt atacatcata 116040
tgggctaatt gaggaagtta acaagcagca aaagagaagg ttagtgattg ttgaatagat 116100
tgctggctaa agcttcctat tttattcatt gcacatcttg aaatgcacca atcagaagaa 116160
cagagacaat gcaaagtaag atgaaccaat gagaatgact ggaagctttg ttctcccttc 116220
ctcttttctt ctgtttagta taaccatgtg gtatccgaag ccaactactc cggattcagc 116280
gtaagggagg atcgccctcc caattcgaag ttttttcctg gaagtttcaa ccttgttgac 116340
tatgacagca gtcacgacta taaacagact cgtgactatg gcaggtccat ggttgtattt 116400
ctgcagggga gccctctgca tttcctgtta gtgtgagaaa gtcaggtcga gatctagttc 116460
tatttatcaa tcagagttag aaagctagct ttaagcaggc cagtctaagt ttgactttgc 116520
cgctggcatt ccagggaccg gcatcttttg agcatgttta gcttccaaaa ttcctggagt 116580
cctacgctac atcattatca ctatatgact agtaaataat tattttatta ttatagaaaa 116640
cgatcaattt tttttatctt ggcttttctt ttttcctctt ttcttcttcc ttatagtata 116700
accatccagt atcgaagcta acatggtcga ctaatttaga ttcagatcag ataatccact 116760
gagacaagaa aaaagcactc tttaccatta ggttttctat tagaggtacc aaaacctcgg 116820
gaagatcaca acctctgcac cacaagccta ggtgttctcc ttcctctttt cacttatttc 116880
cttatataaa taaaatctag cctttggaaa ctttccctaa aatatagaac aatgcaaaca 116940
attgagagtg caatatagta aatgaaacag atcgatttta tggtgcattt gcaaaagttc 117000
ttttagttat atgattatgt tcacatgatt ggtaaaataa agcacaagaa atctttgtga 117060
ggttcacttt cgtctagaat tataactcgt cataagagat tatttcctag agttactagc 117120
atttatgtaa gtcacgtgca ttgggaggaa atcaattatt cactccgtct cattgtgttt 117180
gtttggacat aaaatttaag aaagaaaaac ttttaaaact gtgatattag acatgtcgta 117240
agtattattg tgactataaa atcaagtcat tatgggtgaa cagagaagtt taacgttact 117300
gttttaagaa attatggtgg atgtctatct tcctccatga tcttcctctc aaatgcttaa 117360
tgacatattc aatgacatat ttcttcattt ttcatgccta tatcttggca ttgtaataga 117420
tataaagaac acacaattga agaagaaatt ataatctctc atctctttct ctctatatct 117480
cttagcttat tttttctagt tctatattat tactttgagc tatatttcat aacacgttat 117540
cagcacgaga ctctaccgtc tcaagaagct ctttgagaag actaatgtat aatttttctc 117600
ctcttttaat tatgactgat attataaaaa aaaagtctgt tgcgcttgaa atttcgggct 117660
agaactatat gacatgggtg ttggatgctg aaatctattt agatacaatg ggtcttggag 117720
acaccattaa agatataaat aaagcatcta cccaagactg tgctaaggcc tcgattttct 117780
tgtgccatca ccttgatgaa ggttgaaaat agaatatctc acagtcaaag atctacttgt 117840
tttgtggaat ggcttaaagg aaagatatga caacataaaa ttggtcactc ttccacaagc 117900
acgatataat tgggctcatc taaggctcca agactttaag tctgtttctg aatataattc 117960
tgcgatgttc agaattactt ctaaattaaa actatgtgga gatagtatca gtgactatga 118020
tatgcttgaa aaaatgttca caatatttta tgcctccaat atggtcttgc aacagcagta 118080
ccgagagaaa ggtttcaaga agtactctaa gttgatttct cttctcctag tggctgaacg 118140
aaacaacaac ttgcttatga gaaatcacga aaatcgatcc actaggtcta caccattgcc 118200
taaagtggat gaggtgtatt cccattatgc taagcgtgga aaaggtcgtg accctggtcg 118260
tggccgtggt taaggaagaa aattttcaag tgttaatcat tctccaaaga aaaataactt 118320
ccaaaagtgg aaagggaaag atgagaagcc aaaggcaaag ggttcagaaa ctaaatgcta 118380
tcgttgcggt ggaaaagggc attgggcaaa tattcgtcgc ataccaaaat atttggtcaa 118440
gctttatcaa gcatctctaa agaataaagg ccctgaagct aattttgtct atgacaatga 118500
atttgacatc acccaattgg atgtggcaaa tttctttgag caccctgatg gaaaaataaa 118560
ccacttgatc ggtgatggat tcgtggttaa agatgattga gtagttagat ttttattttt 118620
gcctattcgt agagctaatg aataaacatt atgtaatttt tattgcgctt aataatactg 118680
cttatgtagt tcttaaaaat atatgtattt ccgaagaaat tatttttttt aaagattcaa 118740
tgtttaacaa atcttacaaa tgaggggtaa tatctaatta attagtacct agtctaagtg 118800
atcttttaac acttttgatt ttcctttctg ttactttaat tctctttaaa aaaaagttta 118860
caagcaccct ggaacaactt ttgttacttg accctcaatt cccatcttcc tttttaaaaa 118920
aaaaatctag tacatcggga cctcaatttt ttcatgtaca tggataaaat attaggaata 118980
aagaaaagag aagcagctaa gtatgttctt tttttacaca gatcaattat ttttcatgca 119040
atgtgtaaga aaatataaat aacttataca tgtaaataat tttgttgtag ttatattagt 119100
catatgtgta atgtacttat aattgtatta tttttgctac gtaattattt gtatcataat 119160
tagaatttac tcaaaattgc attaaaaagt cactattgaa tcattggttt aacttttttt 119220
tttttctttt ctctaaaaat actaatattt attcatatac ttgttttttg tatgtcaacc 119280
catgggaaac aaatatggat atctctcaaa gcaaacttgg atcaaagttt aattgtaaaa 119340
atatttgctt aattgattca tgtacgacac atacaatatt caaagagaag aaatatttct 119400
ctcatttaag tatgtgtaag gcagatgtta ctacaatttt tggtagtagt tgtaacgacc 119460
cgaccggtca ttttgaatat tataacctca tttctccatt tactgctcaa tttatgcctt 119520
gttattgatt tatgacttat caggttagtt ggttagggtc cggaagaaat tcggagtgaa 119580
atgagacact tagtctcata attaaaaaaa attaagttaa aaaagtggac cggatatgga 119640
cctatgtgta aacgacctca gattcaaatt ctgataattc caatagctcc gtatggtgac 119700
tttggacttg ggagcgtgtc cgaaaatttt tttggaggtc cggagagaaa ttagacttga 119760
aatgccgaaa gttaaatttt taggaagttt gaccgagggg ttgacttttt tatatcgggg 119820
tcaaaatccg attctgaaaa ttttaatagg tatgttatgt catttatgac ttgtatgcaa 119880
aatttgaggt caatcggacg tgatttgata ggtttcagcg ttatttgtaa aaattagaaa 119940
tttcaaagtt caataggctt gaatttgggc gtaattcatg gttttagcgt tgtttgaggt 120000
gatttgagga ttcgactaag ttcgtatgat gttttaggac tcgttggtat atttggttga 120060
ggtcccgagg gcctcaggta agtttcagat ggttaacaga tcaaaaattg aactacaaca 120120
gctgctgcaa tttccttatg ttgaaaattt tttctgccag attcgagcct agaaatctct 120180
cagaatcgag tccagaaatc gatcccagat gtgagcctag atcgagccca gggtcaaggg 120240
ccatgatcga agccatgatc gagcccaggg tcgaggacca cgatcgaagc catgatcgag 120300
cctagggtcg agggtcacag tcgaaggcag ggtcgaagac atgatcgaag gccagggtcg 120360
agggccatga tcgaggatca ggatcgaagc cacgatcgag gcctaggatc gagggtcagg 120420
atcgagtccc aggatcgagg acctcgatcg aaggccaaga tcgaggcaga accgaggttg 120480
tctgggaaga attataaaat agggacttcg tcctattcgc catttttgac aaattggagc 120540
ttgaggagag gcgatttttg atatattttc aagaaaaact ttaggtaagt tccttgtgat 120600
catttctact ccataatatt gaattattat cgaataatcc gactagatta cctcattttg 120660
aggtgtaaat cggagattgg aacttagaaa tttggaaata agatttgtag atttgagggt 120720
tgagttgagg tcggattttg gtaaaattga tatgggtaaa ctcgtggttg aatcggcttt 120780
cggattttgt aacttttgtc gggtaccgag acataggccc cacgagcgat ttttgagcta 120840
aatttcgaat ttttatgaaa aattagtatt ttcttatgaa attaatttca ataaatttta 120900
ttgactgaaa cgaattattt tttactagat tcgaggcatt cggaggccga tttgcgaggc 120960
aaaggcatag cagttttaaa tctggtcctg agggtataaa accccggatt ttggtatcat 121020
gtgattattt tggaggtgac gcacatgcta ggtgacaggc gtnaagcaga ttctagatat 121080
agttgagccg acaggatcaa ctcaggcacc aactgtgccc attgagattg caggcattca 121140
agagactttg gcccagatat tggcatcctg cactggtctt gctcaggtgg tttcggctca 121200
agccgcacct gccacttctc aggccggggg aggtactcat acccctgtta cccgtactcc 121260
agaccaggta gtacaaggac tacagatacc gggggcacta ccagcccagc cggttgcagc 121320
tgctcaggcc ccggtagttc ctgttatggc aaatgatgag cagaggagag ttgagcaatt 121380
tgagaggctt cgacctccac catttagcag tactgagtca gaggatgctt aggattttct 121440
ggataggtgt caacggatgc ttcagacaac gggtattctg gagaccagtg gggtctcatt 121500
cactactttt cagttttctg ggtctacact cagatggtgg gagacttacg agagacgtag 121560
gcatgttggc tcagcacccc ttacttggca tcagttcttc atctttttgg agaagttcgt 121620
acctcagtcc tgcagagaag agctacgcag acagtttgag tagcttcgcc agggtgatat 121680
gtccgtgacg cggtacgaga tgagatttta tgagttggat catcacgcag tctggttggt 121740
tccctcttat aggtagagga ttaggaggtt cattgatggc ctcacatatc agttgcggtt 121800
acttatgact agggagagag tgtgtggtgc tacttttgat gaggtagtgg acattgctcg 121860
gcaaatagag atggttcata accaggaacg tggagagaga gagagaggct aagaggcctc 121920
gtggtccggg tgattacagc ggtgttcctt caggtggtca gttacaccgt ggtaggggtc 121980
gttcttacag acacgctcag acgggtcgtc tagctcatcg tggtgcatca actggccatg 122040
gttcttacag tgctcactca ggccagtctt cattcagtgc actactagcg cagagttctc 122100
atcatgcctc gtccgcacag gcttctgcag gttattcctc gggttatcag gagcagtagt 122160
tccattagag gaggggttgt ttcgagtgcg gagaatttgg tcacttcaag agagagtgtc 122220
ctaggttgtt gagtggggct ccacagtaga gttctcgacc aacggcacca gcaccagcag 122280
ttacaccacc tgcccagcca gctcggggtg tgggtcaggc agctaggggt cgcccaagag 122340
ggggaggcca atcaggtggc aggcaggctc gattctatgc ttttcctgcc aggccagatg 122400
ttgttgcctc agacgcagtg atcacaggtg ttgtttcagt gtgccatatg gaggcttcta 122460
tattatttga ccctggttcc acttattcat atgtatcatc gtattttgct cattatctgg 122520
atatgccatg tgagtcctta gtttcacctg tttgtgtatc tataccggtg agcgatatta 122580
ttacgtgtgt atcggtcgtg tgtggaaact attggggaac tagagactag agttgatctc 122640
ttattactcg gtatggttga tttcgatgta atcctgggta tgtattggtt gtctccatgt 122700
catgctattc tgtactgtca cgcaaaaatc ttgacgttga cgatgtcggg gttgccaaag 122760
gttgaatgga ggggttctct aaatcttgtt cctagcaggg taatttctta tttgaaggcc 122820
caacgtatgg ttggaaaggg atgcttatca tatttggcct ttgtgagaga tgttgatgca 122880
gatgctccta ttattgattc agtaccggtc ctgcgagact tttcaaatgt atttcctgca 122940
gacctaccgg gtatgccacc cgacatggat attgatttcg gtattgactt ggtgcaggac 123000
actcagccca tttctattcc tccgtatcgt atggcaccag ctaagttaaa agaattgaaa 123060
gagcaacttc aggaactcct tgaaaagggg tttattaggc ctagtgtgtc accttggggt 123120
gcaccggttc tgtttgtgaa aaagaaagat ggtactatgc ggatgtgcat tgattatagg 123180
cagttgaaca aagttacaat caagaataaa tatccattgc cgcgtattga tgatttattt 123240
gaccagcttc agggagagag ggtgttctcc aaaattgatt taaggtctgg gtatcaccaa 123300
ttaaaaattt gggattcgga tattctaaag acggcattca agactcgtta tggccactat 123360
gaatttcttg tgatgtattt tgggctaacc aattccccaa caacatttat gcatttgatg 123420
aatagtgtat ttcagccata tcttgattta tttgtcgtgg tattcattga tgatattatg 123480
gtgtactcac atagcgagga ggagcatgca caacacttgg gtattgtatt acataggcta 123540
agagaggaga aactttatgc caaattctct aagtttgagt tctggcttag ttcggtggca 123600
ttcttgggac atatagtgtc cagtgaagga attaaggtgg atccgaagaa gatagagaca 123660
gatcagaatt aacccagacc atactcagtt attgagattc agagttttct cagcttggcc 123720
ggttattatc gttgtttcgt gggggggttt ctcgtccatt gcatcgccta tgactaaatt 123780
gacccagaaa ggtgctccgt tcaggtggtc agatgaatgt gaagagagat ttcagaagct 123840
caagacagct ttgactacag gtcgagtatc ggtgttgcct acaggttcaa agtcttatac 123900
tatgtattgt gacgcgtcgc agattggtct cggcgcagta cttatgcaag acggtagggt 123960
gattgcctat gcgtccagac agttaaaggt acatgagaag aattatccgg tccatgatct 124020
tgatttagca tctattgttc atgccttgaa aatttggcgg cattacttgt acggtgtcca 124080
gtgtgaggta tataccgatt atcggagtct acaacatttg tgtaaacata aggatcttaa 124140
cttgcggaag tgaaggtggt tggagttgct taaggattat gatatcacca ttctctatca 124200
tcccggaaag gccaatctgg tggccgatgc cttgactcgt aaggcagaga gtttgggcag 124260
cttagcatat ttaccggtag aagagaggcc tttagccttg gaggttcagg ccttggctaa 124320
tcagtttgtt agattggatg tttccgagcc gaatcgagtt ttggcctgtg tggtttctcg 124380
aactttttta tatgatcgca tcagagagcg ccagtatgat gattcaaatc tgtttgttct 124440
taaggacatg tttcatcacg gtgatgccaa ggaagtcact attggagatg acagtgtatt 124500
acgaatgcag ggcaggctat gtgtacctaa tgtagatggt ttgcgtaagc tgattctcca 124560
ggaagctcac agtttgtggt actctattca tccaggcgac gcgaagatgt ataaggattt 124620
gagacagtac tattggtgga ggcggatgaa gaaagatata gttgggcttg tatctcggtg 124680
tttaaattgt caacaggtaa agtacgagca ccagagaccg agcggattgc tacagagact 124740
tgaagttccg gagtggaagt gggagcgtat taccatagac ttcacagttg gaatcccacg 124800
gactttgaga aagtttgatg ttgtttgggt gatagtagat cggttgacca aatctgtgca 124860
ttttattcca gtcgttacta attattcttc ggagcggttg gctgggattt atattcgcga 124920
gattgttcac ctacacggtg tgccggtgtc cattatttca gatcggggta cacactttac 124980
ctcacagttt tggagggcag tgcagcgaga attgggcaca caggttcagt tgagtacaac 125040
attttaccct cagacggacg gacagttcga gcgcactatt cagatattgg aggatattct 125100
acgcgcttgt gtcatcgatt ttgggggttc ttgggatcaa tttctgccac tcatagagtt 125160
tgcttacaat aatagctact agtcaagcat tcatatggct ccgtatgaag ctctatatgg 125220
gagacggtgt cggtctccgg tgggttggtt tgagcctggt gaggttagac tattgggtac 125280
tgacttggtt caggatgctt tagagaaggt caaagtaatt caggaacggc ttcgcacgac 125340
acaatctaga cagaagtgtt atgccaacag gaaggttcgt gatgttgttc acatggttgg 125400
ggagaaggtt ctgctcaaca tttcacccat gaagggtgtg ttgaggttcg ggaaaaaggg 125460
caagttgagc cctcggtata ttgggccttt tgagacactt aagaaagttg gggaggtgcc 125520
ttatgaactt gctttgccac ctagtatatc aggtgttcat ccagtgttcc atgtatccat 125580
gctctgaaag tatgtcgggg atccgtctca cattcttgat ttcagtacag tacagctgga 125640
cggtaatttg acttatgatg tggagccggt gactatttta gactgacagg ttcgaaagct 125700
gaggtcaaag aatatagcac cagtgaaggt gcagtggata gactagccag tcggagaaaa 125760
tacttgggag atggagcagg agatgcggaa caaatatcca cacttatttg agactgcagg 125820
tattattcta aacttgttcg aggacgaacg tttgtttaag aggggaaaat gtaacgaccc 125880
ggcaagtcgt tttgaatatt ataaccctat ttccccattt actgctcaat ttatgccctg 125940
ctattgattt atgacttatc gggttagttg gttcgggttc gaaaggaatt cggagtgaaa 126000
tgagacactt agtctcataa ttaaaaataa ttaagttaga aaagtggacc ggatatggac 126060
ctatgtgtaa acgacctagg attcgaattc tgataattcc aatagctctg tatggtgatt 126120
tcggacttag gagcgtgtcc ggaagaattt ttggaggtct gtagaggaat tagacttgaa 126180
atgccgaaag ttgaattttt gggatgtttg accgaggggt tgactttttg atatcagggt 126240
cgaaatccga ttctaaaatt tttaataggt atgttatgtc atttatgact tgtgtgcaaa 126300
atttaaggtc aatcggacgt gatttgatag gtttcggtgt tatttgtaga aattagaaat 126360
ttcaaagttc aataggcttg aattggggnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 126420
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 126480
nnnnnnnnnn nnnaaatatt gaactacaac agctgctgca atttccttgt gttggacatt 126540
tcttctgcca gattcgagcc tagaaatctc tcaaaatcga gcccagatgt gagcccagat 126600
cgagcccagg gtcgagggcc atgatcgaag ccataatcga gcccagggtc gagggccacg 126660
atcgaagcca tgaccgagcc cagggtcgaa ggtcacggtc gaaggcaggg tcgaagacat 126720
gatcgaaggc taggctcgag ggccatggtc gatgatcagg attgaagcca cgatcgaggc 126780
ccaggatcga ggacctcgat cgaaggccaa gatcgaggca gaaccaaggt tgtctaggca 126840
gaattaaaaa aatagggact tcgtcccatt cgccattttt gacaaattgg agcttgagga 126900
gaggcgattt ttgatatatt ttcaaggaaa acttgaggta tgtcccttgt gatcatttct 126960
actccataat attgaattat taccgaataa tccgactaga ttacatgatt ttgaggtgta 127020
aatcggagat tggaacttag aaatttggaa ataagatttg tagatttgag ggtcgagttg 127080
aggtcagatt ttggtaaaat tggtatgggt agactcgtgg ttgaatgagc tttcgtattt 127140
tgtaactttt gtcggattcc aagacgattt ttgagctaaa tttcggattt ttatgaaaaa 127200
ttagtatttt tttatggaat taattccaat aaattttatt gactgaaatg aattatttgt 127260
gactagattc gaggcattcg gaggtcgatt tgcgaggcga aggcatagca tagtaaatag 127320
tttcatgttt tgaggtaaat aacaatttta aatctggtcc cgagggtatg aaaccccgga 127380
ttttggtatc atgtgattat tttggaggtg acgcacatgc taggtgacag gcgtgtgggc 127440
gtacaccgag gggattgtga cttgttccgt cccgggaaac tgtaaagttg aataatatat 127500
tgttagctat atgctctcta tgtgttgata aaatttgact gtaaatcatg ttagaaatca 127560
<210> 67
<211> 7632
<212> DNA
<213> Artificial sequence
<220>
<223> N.tab-RDR1A exemplary contig Ntab-TN90_AYMY-SS286
<220>
<221> misc_feature
<222> (4586)..(4586)
<223> n is a, c, g, or t
<400> 67
tttgcataac ttttggctct ttctttacca agtaattttt agctcttctt ttagctagca 60
actcttttac cttaatcttg ttattttatt tttattatac tagtattctt acttgtatta 120
cacatgtatg tgacttcaga gggtaatctg gtggtgatta gtatttgaca gttgaactgc 180
acttggaatt tggctatatg ggaaagacaa ttcaggtttt tggattccct tatcttctgt 240
ctgccgaagc ggtcaagaaa ttcttagaga atcatacagg aaatggaact gtctatgctg 300
tggaggttaa acagtccaaa ggtggacgta gagcattcgc catagttcaa tttgccaaca 360
acaaaagcgc agaatttatc atcgatttgg ctagtaagcg gttgtattat ggaacttctt 420
atttgaaggc ttgggaaatg aaaactgata ttgtccaacc gcggacatat gtgcaacaca 480
tggatggcgt aactctgaat tttggatgtc tgatatcaga caagaagttt gcagtgttgg 540
gaagtaaagg tgtttcagtt aaatttggca ttggattgaa gaaaatttac ttctttttat 600
ctcatgcttc agctgattat aaacttcagc tttcatatga aaatatatgg caagttgtcc 660
ttcatcgtcc atatggtcaa aatgctcagt ttctcctcct acaggttttt gaattattcc 720
aaaccttttt tgctatgctt ttcatccttc tccatgtgct agtctttgtg aatatttgtg 780
actatttgat tgttggttga atagtacaca gttctcatgt attgagtgtc ttattgtttg 840
ttgatccgct tcttttgagg caaaatcatt tctgtatatc tgttatgcat gcaaaagtta 900
gacgcacacc agctttgcac ctgtcaattg tttgtgtaat actggaaaag gatatatagt 960
gtgtcaactt tccggccgat gatgataaga acctgttctg agatggctct atattatttg 1020
caatctgtgt tttcctatgt ggttcaataa actatctctg cagcctcttg atttgcttta 1080
caaaaggccc tagtcactaa atgtatcctt gtagcttctt gacttccttt gctcaaaagg 1140
ccgtagtcac caaaagccaa aaatagaatg gctttcattg gttaatgaat aatgatagaa 1200
tatatgctaa agattggctt cagagacaag atctagactg taacaaggtt ctttatccca 1260
aagaaaaaag aactcacaag attttatgat acagcaagaa tttgcaacta ttttgtgagc 1320
tttgaaattg tgctatttag agtctgaaag tgtaggaaat tgatattgtt gcaatgggga 1380
aaactgggcc aaatacacag atagccactc ggagttggta tgaaatgtca gttagacact 1440
aaaagtttac tagtgtccag atagacactt caactcgata agaatgcgac acgtgagcac 1500
ttgggtcata agacctagtg ggtgagtgcg atcatggtcg gcgagtaaat ttctccattc 1560
tctccaggtt ccccaccagc cactaccaac tcaatctctc tcccttttcc agcttcccta 1620
tattgcaatg tggcaaccca tttatatctt gcctattgtt agtttcctcg gttaatttct 1680
ttctcatttg ttgacaaact agaagaacaa catggaaact gttaggaaat gaacctttgg 1740
cgttaatcca accccaaaag caagcttgtg agttgagatt gctcaaagac tgtgtaagga 1800
aattaattac ctcatcccat aacgatgtgc gactctaaca cccccgttct cctctcacgc 1860
ccaagattgg atatttggac cgtggacaat attgagaaac aagaaagaag agaagagggc 1920
ggggaatagt tcacttgatt attccctcaa gccattgggg tttaaaatga cctttacaag 1980
aattacaaat aaggaaagaa aataaaaggc agcaacacct gggagaatta gacaacaaca 2040
acaacccaac aataatccca ctaatggagt ctggggagga tagagtgtac gtagaccttt 2100
cccctatctc gagggtagag aggctgtttc cgggaaacct gggagaatta gacatacctc 2160
taaagctcaa ttccagtata aaaacaccaa tataggactc taaattggtt tagaattgct 2220
aaatttctgc tccaaaatgg ctcctttgtt cattcaataa ttgatgattt ctgtaaactt 2280
aacatcaaga tagttcttct tttcctcctt tatcctctct ttgctcgcta atcaggattt 2340
tatgatgagt taaaatatat tgctattttt tttgggcaaa gtttggcatc tttaaaattg 2400
taatttattt atttatttta gtgccctttt ttcagtttat gagtcaacct ttaccgtttc 2460
agctatagtg cccttttttc agtttatgag tcaaccttta ccgtttcagc tatagtgccc 2520
ttttttcagt ttatgagtca acctttaccg tttcagctat agtgcccttt tttcagttta 2580
tgagtcaacc tttaccgttt cagctattct ttttgggata tttgctaggt gagacattct 2640
aatagtgtta tttacattgt cctttttcat ttgtcagtga tttttgcttt gactacggct 2700
caaacatcta ttttgaagta ctgcattgct tctaatagtc ttttaacaag catgaatatt 2760
tatcatgtga aatagactgg aaaattacta ggtgcaaaag tgtgtttcat agactagagc 2820
catttggata gcccttttag ttcaattata tttttgtgct tagtttttat taaagaagaa 2880
aactcgaaag atgattagtg aacattgaca gtttcttttt accaactaaa tttcttcacg 2940
agtatagttg catcagttaa tatatcgctt tatataattg aaatatggta gatctgtagt 3000
ctactttact gatttaccat gagatttatt atcgatttat tcattcgatt tctgtgattt 3060
agttatttgg tgctcctcgg atctataaga gacttgaagg ctcctgttat agcttcttta 3120
aggaaactcc tgatgatcag tgggtaagga caacagattt cactacatct tggatagggc 3180
tatcttctag cttatgtttg gagtttcgta atggtggtcg acttccaaat ttcagcgaaa 3240
gtttttttta ctataaagaa agtgtgagcc aagttatttt acagactggt tacacctttt 3300
cattctctca aaatttggct ctggttccca ttgtccacct tcctgaaggt gttgagttgc 3360
cctacaagat attgtttaaa attagttcct tgatacaaca tggatgcttt cctggactag 3420
cattaaattt taactttttc caattagttg accctcgaag gagaaatatt gcatgcattg 3480
aacacgcctt ggagaaactg tactatttaa aggagtgttg ttatgatcca gtgaggtggc 3540
taactgagca gtatgatgag tacctcaacc gcagacaact tccaaaatct ccgtccatca 3600
ctttagatga tggattggtg tatgtaagaa gggtcctagt aacaccatgc aaagtttatt 3660
tttgtggtcc agaggttaat gtatcgaatc gggttctgcg caattattct gaagacatag 3720
ataactttct tcgagtttct tttgttgatg aggagtggga gaaaatacat tctacagatt 3780
tattaacaag agctagtagt ggaaatggta tcaggacaga catctatgag aggatcctat 3840
caactcttcg gaatggcttt ataattggtg ataaaagatt tgaatttctt gcattttcat 3900
cgagccagtt gcgggataat tcagtgtgga tgtttgcatc aagacctggc cttactgcaa 3960
atgatataag aacatggatg ggtgattttc agcaaatcag gaatgtcgca aaatatgctg 4020
ccagacttgg ccaatctttt ggttcctcca gagaaacttt gagtgtcggt aggcatgagg 4080
ctgaagttat tcctgatgta gtttgttcgc ttcatggaac caactacatc ttttctgatg 4140
gaattggaaa aatatctgct gactttgctc gtagagttgc cataaaatgt ggccttcagt 4200
atactccatc ttcttttcag attcgttatg gtggatataa aggtgttgtg gctgttgatc 4260
catattcatc aatgaagtta tctttgagaa agagcatgtt gaaatatgaa tcaaacaaca 4320
taaagttaga tgtcctggga tggagcaaat atcagccttg ttatcttaat cgtcaactgg 4380
ttactctctt gtctactctt ggggtgatag atgatgtttt agagcagaag caaaatgaag 4440
cagtagatca gcttgatgct attttgcatg attctttgaa ggcacaggaa gctttagaat 4500
tgatgtctcc tggagagaat actaatattc tcaaggagat gctaaattgt ggttatatgc 4560
ctgatgctga gccgtttctt tcaatnactt ggggtgaaag atgatgtttt cgaacagaag 4620
caaaatgaag cggtagagca gcttgatgct atcttgcatg attctttgaa ggcacaggaa 4680
gctttagaat tgatgtctcc tggagagaac actaatattc tcaaggagat gctaaattgt 4740
ggttatatgc ctgatgctga gccgtttctt tcaatgatgc tgcaaacttt ccgggcttca 4800
aagttgctcg atttgcggac tcgatcaaga atatttattc caaatggaag agcgatgatg 4860
ggatgcttgg atgaatccag aaccctggaa tatggtcagg tgtttgttca gtttactggt 4920
actggacgta gacagtttta tgaggaatca catcctttta atgacagtgg atccaccaac 4980
tgtaatttca ttctcgaggg aaatgtggtc gttgcaaaaa atccatgctt gcatcctggt 5040
gatattcgtg ttttaagggc tgttgatgtt ccagctttgc accacatggt agattgtgtt 5100
gtatttcccc agaaaggaaa aaggtaaaac attactttgg aaacctatta tatctgtttg 5160
atttccatgt aatcttatag agggatttac catttcttgc ctagtcttac taactatcaa 5220
aacgtgttat ttcttttagt gagtgaattt agaaaaactt tacagaaatt gcaactagtc 5280
ttgtcgtacc atgttgaatt cttgattaga atcataactg gaattcaagt tctaccgagt 5340
ctttgaccat gtaatgtttg gtcactcttg catgaaagcg cggttgttgg catagatgtt 5400
tggccaacaa ctatgaaaat caattcctgg aagaagctta tattaggaat ctatatagtc 5460
atgaaatttc attctggaaa caagcatata ctcaaaattt gtgtagcttg acatgaccat 5520
tatgaagtag cttacattgt gtttgcattg aaaagaaagt ggaatttcta ttgatttaga 5580
gtagtattta cttatggcct cgttcttaca tattggcata tctaaggggg gttcctcggt 5640
tcacgtgaac ccacgctctc ctccttagat catgtatagt aatgttattt ttttcaaaaa 5700
gacttaaata tatgtgtgta cccaagctca aagtatcaca tgatgtgata gttattgggt 5760
gcacctctct aagtgatatt ggggattcaa atcttgtgtc tcttgttatt ttttcgtttc 5820
tttttctaga attgggccca cccacgagta tgtgcatgcc tggtgtcatt tcttgtgttt 5880
taattaagta cttttttctt tttctttctt tctttgtttg gtttattctt caaaatttcg 5940
aactcttgac acattgaaat ctctactatc ctttagttac cataaaattt tataattaaa 6000
ccaaatgtgt atagtgaagc tagttgcagt ggatgatgta gcatatagtt aatgggttca 6060
actgatccca acatttctgc cacaaagtgt gtgtgtgtat atataaatat atatttgtgt 6120
gtgttactat taaaaaaata taatttgaac ctaataattt caaaagcgta atgggtacaa 6180
cagtaagaac ctaaaggcct gaaccatcaa aattaatatc ttggatcaac ctcttgttct 6240
tacactgtat gtttggcatg actgaaaagt tctatcaaat aaactagctt ccatccttat 6300
aagaactgtt tttatctttt ttttcatggc attgtttctc agtgtttaaa ctttgatgac 6360
agacctcatc caaatgaatg ttctggaagt gatttggatg gggatatcta ttttgtttgt 6420
tgggatccag acctgattcc gccaaggcaa gtccagccga tggattatac tccagcaccc 6480
agcacacagt tggatcatga tgtcacaatt gaggtacccc tggtttcaaa caactaagtt 6540
ttacttacat aatttagcat gcttctgatg tattcaacct ctcttacctt atagatgtgt 6600
atatgtaatt aaaattgccc actctctgct tactgcagga agttcaagag tacttcacca 6660
actatattgt gaatgacagt ttgggaatca tagcgaatgc gcatgttgta tttgcagaca 6720
gagaacctga tatggccatg agtgatccgt gcaaacaact cgctcagctc ttttcaattg 6780
cagttgactt tccaaagact ggtgttcctg ctgaaatacc atctcagttg cgccctaaag 6840
aataccccga cttcatggaa aagccagaca agccaaccta tcactcggaa aaagttattg 6900
gaaaactttt ccagaaagtg aaggacaaaa cacctcaggc ttgctctatc gcgaccttca 6960
caatggatgt tgccaggaaa tcatatgatg gtgatatgat agtcaatgga ttcgaagatt 7020
acattgacga agctttttac tacaaaagtg aatacgacaa caagcttggt aatttaatgg 7080
actactacgg cgtaaaaact gaggctgaaa tacttagtgg tggcatcatg aaagcatcaa 7140
aaacttttga ccgcagaaaa gatgcagagg ccattggtat tgctgtgagg tctttgagga 7200
aagaagcaag gacctggttc aagaagcgta gtgatataga tgacatgtta gcaaaggctt 7260
cggcttggta ccacgttaca tatcatcata catattgggg tctctacaat gaggggttga 7320
aaagagatca tttcattagc tttccctggt gtgtttatga ccagctgatc cagattaaga 7380
aggcgaaagc acgtaaaaag ccggttctcc atttatcttc tctcgggaat caactgagtc 7440
gcaaattagt gttgatatga tagcattaag ccaatctata taatgtaaaa agggtgtgat 7500
cataagagaa ctgctacgcg ttgttaacaa tcttgtctat taaaccgctg acatttatgc 7560
agctctcttt aataacagtt gtatagctta gtagtattta gcatgcgatt gaagttgttt 7620
tatctctctt ct 7632
<210> 68
<211> 11112
<212> DNA
<213> Artificial sequence
<220>
<223> N.tab-RDR1B exemplary contig Ntab-TN90_AYMY-SS10620
<220>
<221> misc_feature
<222> (7599)..(7698)
<223> n is a, c, g, or t
<400> 68
ggatgtttgc atcaagacct ggccttactg caaatgatat aagaacatgg atgggtgatt 60
ttcggcaaat caggaatgtc gcaaaatatg ctgccagact tggccaatct tttggttcct 120
ccagagaaac tttgagtgtt ggtaggcatg aggttgaagt tattcctgat gtagtttgtt 180
cgcttcatgg aaccaactac atcttttcag atggaattgg aaaaatatct gctgactttg 240
ctcatagagt tgccataaaa tgtggccttc aatatactcc atcttctttt cagattcgtt 300
atggtggata taaaggtgtt gtggctgttg atccatattc atcaatgaag ttatctttga 360
gaaagagcat gttgaaatat gaatcaaaca acataaagtt agatgtcctg ggatggagca 420
aatatcagcc ttgttatctt aatcgtcaac tggttactct cttgtctact cttggggtga 480
tagatgatgt tttagagcag aagcaaaatg aagcagtaga tcagcttgat gctattttgc 540
atgattcttt gaaggcacag gaagctttag aattgatgtc tcctggagag aatactaata 600
ttctcaagga gatgctaaat tgtggttata tgcctgatgc tgagccgttt ctttcaatga 660
tgctgcaaac tttccgggct tcgaagttgc tcgatttgcg gactagaaca agaatattta 720
ttccaaatgg tagaacgatg atgggatgct tggatgaatc cagaaccctg gaatatggtc 780
aggtgtttgt tcagttttct ggtgctggac gtagacagtt ttttgaggaa tcgcatcctt 840
ttaatgacag tggatccgcc aactgtgatt tcattctcaa gggaaacgtg gtcgttgcaa 900
aaaatccatg cttgcatcct ggtgatattc gtgttttaag ggctgttgat gttccagctt 960
tgcaccacat ggttgattgt gttgtatttc cccagaaagg aaaaaggtaa aacatcacgt 1020
tggaattcta ttaactgttt gatttccatg ttaatcttat atagggattt accattgctt 1080
gcatggtctt actaacaatc aacgtctttt tcttttagtg agtgcagtta gaaaaacttt 1140
aaagaaaatg caactagtcg tgtcctacca tgttgaacgg tttctttctt cttttttttt 1200
tcatggcgtt gttactcggt ggttaacttt gatgacagac ctcatccaaa tgaatgttct 1260
ggaagtgatt tggatgggga tatctacttt gtttgttggg atccagactt gattccgcca 1320
aggcaagtcc agccgatgga ttatactcca gcacccacca cacagttgga tcatgatgtc 1380
acaattgagg tacccctagt ttcgaacaac taagttttac ttccataatt tagcatgctt 1440
ctgatgtatt caacctctct taccttatag atgtgtatat gcaataaaaa ttgcccactg 1500
tctgcttact gcaggaagtt gaagagtact tcaccaacta tatcattaat gacagtttgg 1560
gaatcatagc aaatgcgcac gttgtatttg cagacagaga acctgatatg gccatgagcg 1620
atccgtgcaa acaacttgct cagctctttt caattgcagt tgactttcca aagactggcg 1680
ttccagctga aataccatct cagttgcgcc ctaaagaata cccagacttc atggaaaagc 1740
cagacaagcc aacctatccc tcggaaaaag ttattggaaa gcttttccag aaagtgaaga 1800
acaaaacacc ccaggctagc tccatcgcga ccttcacaag ggatgttgcc aggaaatcat 1860
atgatagtga tatgatagtc gatggattcg aagattacat tgacgaagct ttttactaca 1920
aaagtgaata cgacaacaag cttggtaatt taatggacta ctacggcata aaaactgagg 1980
ctgaaatact tagtggtggc atcatgaaag catcaaaaac ttttgaccgc agaaaagatg 2040
cagaggccat tggtgttgct gtgaggtgtt tgaggaagga ggcaagggcc tggttcaaga 2100
ggcgtagtga tattgatgac atgttagcaa aggcttcggc ttggtaccat gttacatatc 2160
atcatacata ttggggtctc tacaatgagg ggttgaaaag agatcatttc attagctttc 2220
cctggtgtgt ttatgaccag ctgatccaga ttaagaaggc aaaagctcgt aaaaggccgg 2280
ttccccactt gtcttcactc gggagtcaac tgagtcgcaa attagtgata tggtagcatt 2340
aaggcgatct atataatgta aaaagggtgt gatcataaga gaactgctat gccttgttaa 2400
caaccttttg tcttttaaac tggtgatata tttatgtagc actctttaaa acagttgtat 2460
agctaagtag taattagtgt gcgatttaag tttgttttat ctctcttctc tacatgtttc 2520
atgttatgat ttatgtatta cgcttaactt caagtgattt cttgatatac tctcctccct 2580
caaacgaaga cagcaattaa aggtaatttt tctcccacaa ttttttcctt aaagtatcgc 2640
tatatattgg catgactaat ccagattcac tatgaaggtt tttagtgctc ccaatcgaag 2700
agaatattct caaacttgga gttggacatg atctctgaac tccaccctgt cacgagggtt 2760
gaaaatgttc aaaacttcta gaaaattaat ggtcttaacc atttttaacc ttagaagaat 2820
agccagcgta aagatgttgt ctttctattt cagaggtcta tcacacaaaa taacaattta 2880
gtaggaggaa tgcttggaag tcctaacttt gaagatcata aatcctgcga aattcaatga 2940
cttttagggt gtgtttggta ggaaggaaaa tgttttccta gaaaatattt ttcatagaaa 3000
atgagtgatt ttatcactta tttttccttg cttgtttggt tggtgagcga aaaacttttt 3060
ccaaaaaata ttttatagtg tttggttaga gagcagaaaa tattttttat gctactctcc 3120
tcaccccctt cccccatgtt tccttgctcg cccccttcta aatttttaac gttttcagga 3180
ctttattttt ttcaacgaat ttaattattc ttctaaaaat tcacacaaac ccaaaggaac 3240
taatgtgttg catttttacg caaaaataaa tttaaaattt gtgttccata actaaacaga 3300
aaatattctt ttttttggtt gaaaaataaa gtactatttc tacaacatga aaatgaagta 3360
ctcattttat tgaaataaaa gaaaatactt ttctacatca cgaaaagaaa atactttttt 3420
gttgaaatga aaaactactt tttctatgga aagaaagtac ttttttttgt taaaatgaaa 3480
aaaaatactt ttttatatca tttaaaaaaa ttactcattt gttgaaatgc aaaaaaaaaa 3540
actatctata acatgaaaat aaaatattat taataatatt tttatttagg acggtactat 3600
taacaaagac aagtgaattt tagacccaag tgaatttctt ttcgtttgtt ttcaatatgt 3660
actttgtttg gccgtccgct caaggagaag ttccacattg caaacaacgt gcgactttag 3720
agtttagaca taacaaaacc tgatgcagag cgggttggtg gggatgtgga acagggtggg 3780
gaaggttaaa aaagagtttt ggaaaatatt ttctcattct cttaatagga aaaatatttt 3840
cctccaattg gaggaaaatg aattcatgag aaaaatgttt tccaaaacat ttaagccaac 3900
caaacatgaa aaaattgaaa aatattttca tttcatacca aatacaccct aagtgtaaac 3960
tacatataaa gcttggactt taatgaataa agaagcaaaa gataaatgaa tatgtttaat 4020
gctggaataa taactataaa cacagacaac aaactatatg gacaacagga caagagaatt 4080
gaaataatta caataagtaa aactttaatt ctaattgttt cgtgatgtcc tcatcaagat 4140
agagagagct catggttaca tgggacacac ttttacatct tgatgcctgc attgaagtgt 4200
cgcctatgtt gcacgacgtt tcagtagaac agtgggtact atttagggtt gaggcgtagt 4260
gttgtaaaac ccatctcttt gtcacttaaa gctattaaat gatgtgaagc aaggagttat 4320
agcttcattg gtgaagtcat gcacggcaaa gttcaatcat atatagccct ataccgttac 4380
acttgaacaa aaatgcccat atccgtcaag agatccagac ccaacactaa aatagacacg 4440
tggggggaca ataaacattt taaaacaacc ggttcatttg tccaaaccca ttactcgatc 4500
catcctgaaa tcctctttta acccatctcc attgttcatt ttagaggagg tgccatacac 4560
aaatagtgga agaaccctgt ggctctacct ctctcactaa gtgttgtatt tttctttgtg 4620
ttcagtttct cctaagaggc tagatataat aggcttgcaa ataacctttc aacctatttt 4680
ctttttagtt catgcaaaaa gaattattcc ttttcatatt tgaaaatgat cctaacatag 4740
ggtacaccac tccccagttg atgttatttt agacataggg tacaccagtc cttagtctca 4800
ttacaagtat aggggacacc aatccctatc tttgttttcc aatatagggt atacctatct 4860
ctagttgatc tgatcttaaa tgcagagttc accactccct gatatctttg ttaatatagg 4920
gtacatcatt ctctcatcac atttccctaa cataaggtac accaatcctt agttgaggca 4980
ccatttagac aatcagggta taccattccc aaagtatcat attttcctag ggtacactta 5040
tcccaacctt ttattgcttt caataatgaa gtagtataga gttttgttac aaataactca 5100
tgaaattttc ctagtgaaaa ctagagcaaa acaatttcat ttgtttgttt ggtttggtat 5160
ttgagtaggt tttacctcaa ggcatggggt tcgaaatgac caaatgaata agtctcaatc 5220
caaaataaag aaaagaaaag aaaaaaagtg aatccaaaat gcagaagcgg atgaaaggat 5280
atggactgct caagacatga ctgaagtcac gagcattgca tttcctgttt tgatcaaaag 5340
aagccataga agaatgaact agcacttgcg gctagcaagc attaaggttc agatcaaagt 5400
ttgcgtgaag aactaaccaa gactcaagat caatcttcaa aatacgtata gataggaatg 5460
ttttaactca tagttgatag gcttgtttag ttttttttga ttttgatttt ggtgtaataa 5520
ggagttcagc aagcagtaac agcatcgaca ttagtgaaat catggcattt aagtagtccc 5580
agctaccaaa atttccagaa ctacactaac ctaattcctt tatagccaag gatgtgtagg 5640
caaccccgaa agcaaggttt ggtcaaaact tttcaaaatg cttcccatgg agtgtcaaac 5700
aggaaataat tggtcgtaat tgctcacttt atctttgcgc ggaaactctt catattctcg 5760
agaaaagagg ggcagctgtg agcgcataat attttcctca catatgaaat cactcctaaa 5820
aatatcccaa ataatttttt ttactttgta gaattttaaa agttttattt gattgcatct 5880
ttatttcatt ggtagatcat ttgcatcatt aggattattt taaaaccatc agaaatattt 5940
tattattcat tttttgcatt tttagatgat aatcacatta ttggaattta gttggcatgt 6000
agttgcatta gttaagcaca caaaatcaca aatattgcat tggtcgtttt tctttgaatt 6060
ttagttagta attcaattaa agcttaaggt gataattagt taattattag acaaattgga 6120
taattaggtt agggtcaaat taaaaattca attaaattgg ccaagtttga attagaagca 6180
aaagaaaagc tgttgggcca agccctgagg ctcaaacacc tttaataatc cgcccagacg 6240
accctcatat ccggaccata tcccttttat taccaaacga ccccattttg tccttaatca 6300
atcccaaccg tccctcaaaa tcaatccaac gactccgaac tgaactccaa accccttaaa 6360
actgtctgaa tgaatacccc aaaccctaaa taccaatccc aattcctcat ccctctcacc 6420
ctctcaccct tagccgccta ccacaccaaa gagtatctcc gtcggtggct cgtctccaag 6480
tctgccaaaa tatcacaaaa taacctttgt tccctcctct ttccaaatct cttagcctca 6540
tctctcgact ccctctttat cgattcgtat agcagatcta aaaatgacca taaaccctag 6600
tttgcctatt tttacctgat ttttcagtgg tttatgaact ctttttggcc actccgattg 6660
cctctgaagc cgcttcgtct tctccaaatt tggcttgtaa tgaatatttt tccatgtagc 6720
attggatcgc atgtgaattt ggcggcttgt gctcatgtga caatctccat tacatgccag 6780
aattcttgta tttgccggtg ttggtttggc tttccggatt ccagcttcac ggatatgtta 6840
aaggttaatc gtggtaagat ttcactgctc cagcctcttt agctgttatg ttttatttga 6900
ccataatgac tttccattca tgactagcta tgtgacttcg tacaagtcat tttaagaccg 6960
tttctgctgt gaaattgcat tcgatttact gttagttaat atttcttttt tgagttgtaa 7020
ttttctaagt tcaagtgttt gttgccttgt ttaatttgca aattggttta gttgatttgt 7080
taggattaat tggagcaaac ctgttattag gttgatatga gtatagagag agtaagagct 7140
ttgagattgg ttaattttct ttttcttcaa ttaaaaaatg caaaggttca gttatgatta 7200
tcggagtaag gcccaatact tgtttctttt aagtcagtat agtttaaaag gacggggagc 7260
tatgggtaat ttcttaattt agggaatatt acggaaaggt tctagaaaag ggagaaaagg 7320
actagtatgc aataaaaaaa cagaacatgg caagtgttta gggggcttag gggtaaatac 7380
agaagtaaaa ggggctgaaa aataaggaaa gaatatctga agtggacagc tgcccaaatc 7440
tgttaaaaaa atgcatttta ccctattttt ttagggcaga cggattccct agtcattctc 7500
tcatcttttt tgcatatagc acacacacat attctctaat aacaaactat gcacatttcc 7560
tctcctcaca gacctgaccc catcttttct tatatatann nnnnnnnnnn nnnnnnnnnn 7620
nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn 7680
nnnnnnnnnn nnnnnnnntt atcaccaatt ataaagccat tccgaagagt tgataggatc 7740
ctctcataga tgtctgtcct ggtaccattt ccagtactag ctcttggtaa taaatctgta 7800
gaatgtattt tctcccactc ctcatcaaca aaagaaactc gaagaaagtt atttatgtct 7860
tcagaataat tgcgcagaac ccgattggat acgtttacct ctggaccaca aaaataaact 7920
ttgcatggtg ttactacgac ccttcttaca tacaccaatc catcatctaa agtgatggac 7980
ggagattttg gaagttgtct gcccttgagg tactcatcat actgctcagt tagccacctc 8040
actggatcat aacaacactc ctttaaatag tacagtttct ccaaggcgtg ttcaatgcat 8100
gcaatatttc tccttcgagg gtcaactaat tggaaaaagt taaaatttaa agctagccca 8160
ggaaagcatc catgttgtat caaggaacta attttgaaca atatcttgta gggcaactca 8220
attccttcag gaaggtggac aatgggaacc agagccaatt tttgagagaa tgaaaaggtg 8280
aaaccagtct gtaaaataaa ttggttcata ctttctttat agtaaaaaaa actttcgctg 8340
aaatttggaa gttgaacacc attacgaaac tccaaacata agctagaaga tagccctatc 8400
caagatggag tgaaatctgt tgtccttacc cactgatcat caggagtttc cttaaagaag 8460
ctataacagg aatcttcaag tctcttatag atccgaggag caccaaataa ctaaatcaca 8520
gaaatcgaat gaataaatca ataataaatc tcatggtaaa tcagtaaagt agactacaga 8580
tctaccatat ttcaattata taaagcgatt atattaactg atgcaactat actcgtgaag 8640
aaatttagtt ggtaaaaaga aactgtcaat gttctctaat catctttcga gttttcttct 8700
ttaataaaaa ctaagcacaa aatataattg aactaaaagg gctatccaaa tggctctagt 8760
ctatgaaaca cactttttgc acctagtaat tttccagtct atttcacatg ataaatatag 8820
tacatgcttg ttaaaagact attagaagca atgcaatact tcaaaataga tgtctaagcc 8880
gtagtcaaag caaaaattac tgacaaatga aaacagatta tgtaaataac actattagaa 8940
tgtctcaact agcaaatatc ccaaaaaaat agctgaaacg gtaaaggtcg actcaaactc 9000
aaaaaaggtc actcagataa agaaataaat tacaatttta aagatgccaa actttgccca 9060
aaaaccatag caatatattt ttacccatca taaacccctg attagggagc aaagagagaa 9120
aggataaagg aggaaaagaa gaactatctt gatgttaagt ttacagaaat tcctcaatta 9180
ttgaatgaac aaagaaaatt tagcaatcct aaaccaattt agagtcctat attggtgtaa 9240
ttatactgga attgagcttt ataggtatgt ctaattctcc caggtgttgc tgccttttat 9300
tttctttcct tatttgtaat tcttgtaaac gtcattttaa accccaatgg cttgagggaa 9360
taatcaagtg aactattccc caccttcttc tctcccttct tgtttctcaa tattgtccac 9420
gctccaaata tccaatcttg ggcgtgagtg agaacggggg tgtttagagt cccgcaaagg 9480
tatgggatga ggtaattaat ttccttatat agtcttgagc aatctcaatt catgagcttg 9540
cttttggggt tggattaaag ccaaaggtcc atttcctaac agtttccata ttgttcttcc 9600
tgtttgtcaa cgaatgagaa agaaaaaaac cgaggaaact aacaataggc agagatgtaa 9660
atgggttgtc acattgcaat attggggagc tggaaagggg agagagattg agttggtagt 9720
ggctggtggg gaagttggag agaatggaga aattaacaac cacgatcgta actcacccac 9780
taggtcttat gacccaagtg ttcacgtgta gcattcttat caagttgaag tgtctatctg 9840
gacactagta aacatttagt gtctaactga catttcatgc caactccgag tggctatctg 9900
tgtatttggc ccagttttcc ccattgaaac aatatcaatt tcctacactt tcagactcta 9960
aatagcacaa tttcaaagct cacgaacaac aacaaattct tgctgcatca taaaatcttg 10020
tgagatcttt tttctttggg ataaagaacc ttgttacagt ctagatcttg tctctgaagc 10080
caatctttag catatattct atcattattc attaaccaat gaaagtcttt ctatttttgg 10140
cttttggtga ctacggcctt ttgagcaaag gaagtcaaga agctacaaga atatgtttag 10200
tgactagggc cttttgtaaa gcaatcaaga ggaccacata ggaaagcaca gattgcaaat 10260
aatatagagc catactcaga acaggttctt atcatcatcg gccagaaagt tttgacacac 10320
tatatatcct tttccagtat tacacaaaca attgacagct gcaaagctgg tatgcgtcta 10380
acttttgcat gcataacaga tatacagaaa tgattttgcc tcaaaagaag gggatcaaca 10440
aacaataaga cactaaatac atgagaactg tgtactattc aaccaacaat caaatagtca 10500
caaatattca caaagactag cacatggaga aggatgaaaa gcatcgcaaa aaaggtttaa 10560
aataattcaa aaacctgtag gaggagaaac tgagcatttt gaccatatgg acgatgaagg 10620
acaacttgcc atatattttc atatgaaagc tggagtttat aatcagctga agcatgagat 10680
aaaaagaagt aaattttctt caatccaatg ccaaatttaa ttgaaacatc tttacttccc 10740
aacactgcaa acttcttgtc tgatatctga catccaaaat tcagagttac gccatccatg 10800
tgttccacat atgtccgcgg ttggacaata tcagttttca tttcccaagc cttcaaataa 10860
gaaggtccat aatacaaccc cttactagcc aaatcgatga taaattccgc gcttttgttg 10920
ttggcaaatt gaacttttgc gaatgctcta cgtcctcctt tggactgttt aacctccaaa 10980
gcatagacag ttccatttcc tgtatgattc tctaagaatt tcttgactgc ttctgcagac 11040
agaagataag ggaatccaaa aacctgaatt gtctttccca tatagccaaa ttccaagtgc 11100
agttcaactg tc 11112
<210> 69
<211> 7412
<212> DNA
<213> Artificial sequence
<220>
<223> N.tab-RDR2A exemplary contig Nitab4.5_0006831
<400> 69
tacgcataac gatacaaatc tactagacag acaagacaag acctagggag attaaaagaa 60
aaactctgag cccacatcaa ataaattgtt tatttttaca agactggaac acagaaagtg 120
aaaataaacc ctgtaaaaac cccattcaac tttcccattc gccattcccg ttcatacaat 180
gggtgtagag aagagaatta cagcaactgt gagggtctca aacattcctc aaacagccat 240
agccaaacaa ctcttcgact tcttcgagtc ttcaattggg aaaggatcag tctttgcttg 300
cgatattttc tcagagcaca agaattggaa atcaagaggt catggtcgag tccaattcga 360
aacagcgcaa tccaagttac aatctttatc actatctgaa caagggaagc tcgtctttaa 420
agggcaccaa ctcattctaa cctcgtcttt tgatgatatt attgccaggc caattgagcc 480
caactacagg tttcaaaagg gaatcttgca tactggggta ctgttaaaga atgattacat 540
ggaagttttg gagacttggg aaaatgtgaa gacgttgatc atgcctgaaa gaaagagtct 600
tgagttctgg gttagtcatg caaaggggga atgttatagg ttggaggtcc agtttggcga 660
cattatagag acttgtgggt gctctttgga agatgaaaaa cctgcactcc ttttaaaggt 720
tgatttttct gttacccatc ttgaaaattt tagttatttt tacatccttt taatttatat 780
tgattttagg gcttgccaag agctaaggtg gccactgaca agtgctggga gctcagtgct 840
ttttcaatat tgtgtatgtt tttgtgtatc tcagttagtg gcagagccgc agcaaatgaa 900
gggggttcaa ttgaatcccc tttgctgaaa aattgtactg cataaatagg gcataaacaa 960
ttcttctata tataaaaact tatgaatccc ctcgacataa gggaagtctt cattgtagtg 1020
gcaaaggtag tacaaaaatt gctatagctc gcatgtttga atattttgaa tccccttatt 1080
aaaattcctg gctccaccat tgtgtgttta taactttata ttagacttcc tataatagtg 1140
atacactctc gagggttgaa gaaaatatga attgaagact aagagctatt tatagctctg 1200
caaatggatt tacaatgctt taagtaagaa gaaagagggg atcagaacga gcccaaagca 1260
cacaatctca ctattcacag ggatggagtc ttaataaaaa aaattatcaa cgggatttat 1320
gcataataat agaaactact aatgtaaaag aatccaggag ttctatggtg ttaactccca 1380
aaacttataa ccaactgagt tttcttaatt aaccaatggt tacatgcttc tgctagctga 1440
acgtacaacc cgtgcaagct agtcaaaacc tccctcttcc acttccattt taaagctgta 1500
tcaatttttc cataagcaca ttttatgatt tagtaaggat gctagggcta acctttataa 1560
agtggcctat aaaggttagc ccttgaagtt cctcttcttc ctcacttgca gttgcagttg 1620
cacgttttct ttttttgaaa atatccaatt cgaaggagaa gaatactctt ggttgtgtat 1680
gcaactaaaa gtcagtcata agttaaaata agcttcaaag tctgcagatc gtgagctgcg 1740
cgagcattgg ggaagatatg atttaagagc gtgctgggaa aacatagtac tccgtatggt 1800
tttgcgtctt gcactatata aaagacattt tagactttta ttatatagca agtcaaggat 1860
ataatataga gagtcaggta gaacttagat agaagaatca gtactgtgca agagcattct 1920
tctgctgtat tgaattaaat cagatatctt tttgatttct tatgaaactt gttttacaga 1980
atcatacagt ttacacagtc tgtatggttt ctgaatagtt agctgatcct accaaaagtc 2040
tgtggcaggc ctagtgaaca aggggggttc cgaagtactt ggatacagtt tcagtaaaag 2100
tcttaataat aattttgggg ctaataaggc tattttcatg gcagggtaaa ttagacggga 2160
ttgtgcatct gtcgtggatg cttctgtcac catttgttct aagaacacat ttttttggtc 2220
taagaaaaca tttattatgc attgactagt ctctgagttt aatttctttc actattcatt 2280
gtcttatgta gagaacagca taaagggata acagttcttt tattgatgta tttggtacat 2340
gcaatggaaa ataacaatag ataacatcct atccgagaga ttactttatg aaaaaaatac 2400
acctatggca taaccttaaa aagagaaaca aaaatcccga agcaaaccaa aaagaaaaag 2460
tgaaaatcct ctgaagggaa atggagaaac attatgcggt aatgaaatct tggcattggt 2520
gaattttaga ttcttcaacc tttatttctg aggcaaagcc aatttctttg attttcattt 2580
cagtgagttt ttgctttcag ctaaaacatg caccaaagct ataccaaaga gtttctggac 2640
ccggtgttgc ttcaaagttc agttctgacc ggtaccatgt ttgcaaggag gattgtgagt 2700
tcctttgggt tcgcacaact gatttttctg ccatgaagtc tatcggatgt tcatcctctc 2760
tttgttggga aatcgaagac ggattgttaa gttcagattt gctttctagt ttgccatatt 2820
gtaacaacga tgtgatggat cttgttctgg atgaagtagg agatatttat tctgcttctg 2880
aattagttcc tcttgcaagt ttcccatcag atctgaagct accatatgag atccttttcc 2940
agcttaactc tctcgtacac acacataaaa ttagtcttgg tgctgttaaa actgatctta 3000
ttgaagttct tagcaaatta gaattggaca ctgcaatgat gatccttcag aaaatgcata 3060
agttgcagtc aagctgtttc gagcctgtgc cattcatcaa gacacgcctg catgtattgg 3120
gtaaaaacag taagaaccaa ccttcatcat cttacagcag gttagtgaat caaaacatga 3180
tgagtgttca cagagtcttg gtaacaccat caaaggttta ctgcctgggc ccagagcttg 3240
aaacctccaa ttacatcgtg aagaactttg catcacatgc ttctgatttc ttgagagtaa 3300
cttttgtaga agaggattgg agtaaacttt ctcctaatgc catttctata agtgttgaac 3360
aaggtatctt tgcaaagcct tacagaacta aaatctatca tcggattttg tctatccttc 3420
gagatggact tgttattgga actaaaagat ttcttttcct ggcgttctcg gctagtcagc 3480
tacgttcaaa ttcagtttgg atgtttgctt ccaatgagta tgtcaaggca gaagatatca 3540
gagagtggat gggctacttc aacaagattc gtagtgtctc gaaatgtgct gcaaggatgg 3600
gtcagttgtt tagcacctct tttcaaacaa tggaagtcca atcgccgcat gttgagattc 3660
ttccagatat tgaagtaacc tctgatggcg ttagttattg cttctcagat ggcattggaa 3720
agatttctca agcttttgcc agtcaagttg ctcagaaatg tggattgagt tataccccat 3780
cagcatttca aatacgatat ggtggttata aaggcgtgat agctgttgac cgcaattcct 3840
atcgaaagct atctctacgt ggcagtatgc tcaaatttga atctaagaac aagatgctta 3900
atattaccaa gtggagtgat gccatgcctt gctatctgaa ccgggagatt gttatcctct 3960
tagctacgtt gggagtggag gataaagtat tagaagacct gctagataat catctccatc 4020
ttctgggcaa gatgttgacc actaatgagg cggccttaga cgttttggag agcataggtg 4080
ggggtgacgt aaaaagaatc ttaatgagga tgttgcacca aggatatgcg cccaatttgg 4140
agccttatct ctcaatgatg cttcaatccc attttgagaa tcagctttca gacctaagaa 4200
gtaggtgtcg tatattcata cccaaaggtc gagttctagt aggatgccta gatgaaacag 4260
gtatattgaa ttatggccag gtttatgcac gaatcaccat gactaaggcc gagctacaaa 4320
gtggtcagca aaatttcttc cagaaggtgg atgaaacaac tgcagtagta agaggcaagg 4380
ttgtggtaac aaaaaatcct tgtcttcatc ctggagatgt aagagtactt gaagctgtgt 4440
atgaggtggc attagaggaa aaggcctggg tggattgcat tatttttcct cagaaaggtg 4500
aaaggtatat gttcagtata cgatatttga gtagaaaatg ttcagtatac ggtatttcat 4560
tgggactttc atatccaaac tattttactt gatttgactt gtcggccata cactgtcctt 4620
ttccacagtc tccatgaaga ccgctggaaa gtcttgcaat gttttggatg tttaatgata 4680
ggacataact gaaattaagt ggctagtgct aatagattca attaaatatt tttgattagt 4740
actaatagcc taaccctact accttggggt tgacgcgttg cactacttgt tataaattat 4800
agtactaatt actaatatgt tctagtagtt gcactgcata tcttatcttc ttctgctgga 4860
gattcatgta ttctatgatg ttactaacag tgttatttca gaggtgttca ggtagctttg 4920
tctgtccata ttaacagctc tgagatcaga tggagctata ccacaaacat taacctaatg 4980
tgtatatcca gttgccaggc ttttgtaatg aagaagaaac ttttaatacc attagggagc 5040
ttgcttggcg actgaaacat tagttttcgt caccctttca caaagactgt ctttcatgtt 5100
tttcgtctta acataattca tcataatgtt ttagcatgtg tgaagagttg aaaagaggtc 5160
tgagcagagt tggttagtct tggagcagaa gtctgctttc gacattttcc ctttcccaac 5220
ttattatttt tattgtgctt ccacatccct cctccttaag ggggttaaag ggaaattata 5280
atagatgaag aaaacatttc tgagagaatc aagaactctt taagttttct gcgtactgct 5340
caaaggggat taaatgttct tttgagtact caggagtatt gaattgtcat gtacaggcct 5400
catccaaatg aatgctccgg tggtgatctt gatggagatc tttatttcat aagttgggat 5460
gaaaacctca ttcctcgtca aactgtgaca cccatggact acactgggcg aaaacctcgt 5520
ataatggatc acgaagtcac tctagaggta gcttgaacta tttcttccac gagtgaagaa 5580
acattttttt tttctgcata cctctctgat ttttggtttc tttccctgat ttttcgcagg 5640
aaattcagag attctttgtt gattacatga ttagcgacac tcttggtgcg atctctactg 5700
cacatttggt tcatgcagat cgtgaaccag ataaagctct gaatccgaaa tgcctccagt 5760
tagcgaccct tcactctatg gctgtggact tcgcaaaaac tggagctgca gctgagatgc 5820
caaggtttct aaaaccaaga gagtttcctg atttcttgga gaggtgggac aaaccaatgt 5880
atatttctga aggggtacta gggaagcttt atcgtgctat agtcaagtct tctgttcgcg 5940
gtaactcaga tgaccttggc tctgtcagag ctatccagga tgcttatgat catgaccttt 6000
tgttcgaagg ttacgaggca ttcatcgtaa cagctaaaaa tcacaaagaa atgtacttgg 6060
atagaatgaa cagcttactc aactactatg gagcagagaa agaggttgag atactgacgg 6120
gcaatttgcg ccagaaatct gtgtatttgc agcgggacaa cagaaggtat tttgaactaa 6180
aagatcgaat cttggtttct gccaaaagcc tacagaagga ggtgaaaggg tggttcactg 6240
gttgctgcaa ggaggatgag aagaagaaac tggcatcagc atggtatcaa gttacttatc 6300
atcctagtta ctgccaagga agtgctaatt gcctgggatt tccctgggtg gtaggtgacg 6360
ttttgctgga tataaagttg cataatacca gaaaaatcac ctcctagttt tcaaccatga 6420
aagatacttt atgcattgcc cttattaacg tgtgtaatca tcctgtctta ctaaaataga 6480
tgtatagccc tctgcctaat gtagactttt gacattttct tatggaagtg ctattgactc 6540
aatctgcatc cgatctaaca attagatgta ttaggggttg attggttgga aacaagttat 6600
cccagggtta gttatcctgg gattagttat tccaccctcc catacggata aaaaaacact 6660
acaatcccgg gattagttct accttgattt tatttcaacc aaacatgaga taaacacgtc 6720
tcaaatttaa tcctgggatt aattatccct tatccctcat accaaacgag cccttagtgc 6780
tttgagagca tagcaatatt ttcatgcaaa attggtcata attttctcaa gaccttcgcc 6840
taggtcctaa catatttccg agtaagtaat cctcaaaccc ccaacattgg aacaaacaga 6900
aggcagcata acgagatgcc ttatttctca gttcttcata tatgtcaaac atgtaaaaaa 6960
tgtaaaacca aattcaagtt taggttcgat aatgttagta ctgtgttata tagctgagga 7020
gccaccactt acccagatat ctaaaatata tcttaccaag cactcattat ctttatcttc 7080
ttccaatgaa tttaatttag aaataaaaaa ctggaaatac tgcgtaatac aagtgcttga 7140
cagttgacag tttggttgag tagggataaa agcacaaaaa gaactcatat aaagggtgga 7200
gagaaaagca aaggattatc tccgcttcat tttttttttc tcctttattt gataaggagg 7260
attatctcca ctttgtgaaa ttgacaattt cgtgagcagc actctttatt tatctaataa 7320
atttttatcg cccaacaaaa agaaatatcg caataataaa gcaatctctt cgttccattc 7380
tatgtaaggt gttaaaatac aaaaatactt ct 7412
<210> 70
<211> 6795
<212> DNA
<213> Artificial sequence
<220>
<223> N.tab-RDR2B exemplary contig Nitab4.5_0010542
<400> 70
tattaatagt agctgaatat tcctaatttg tcgagctaaa ttgaggaatc aatcaatccc 60
gagatttttt cctgattttt cgcgggttat taagggaaaa ttctgcccta ttaattccta 120
ataaacgaat ggtatagaat ttgtaggaaa aatatggact aggcggataa tttaaatact 180
atacacatat ttgataataa agtttcatat atggtacatg aatgaaaaaa tgcccgatat 240
aaatctcgtg gacaagacaa tacctaggaa aagatgaaaa gaaaaactct gagcccacat 300
caaattaatt gtttattttc acaagactgg aaaacaaaaa atgaaaaata aaaccctcta 360
aaaaccccat taaacgctcc cattagccat tcccattcaa gcaatgggtg tagagaagag 420
agttacagca actgtgaggg tctcaaacat tcctcaaaca gccatagcca aacaactctt 480
cgacttcttc gagtcttcaa ttaggaaagg atcagtcttt gcctgcgata ttttctcaga 540
gcacaagaat tggaaatcaa gaggccatgg tcgagtccaa ttcgaaacat cgcaatccaa 600
gttacaagct ttatcactat ctgaacaagg gaagctcatc tttaaagggc accaacttat 660
tctaacctcg tcttttgatg atattattgt caggcccatt gagcccaact acaggtttca 720
aaagggaatc ttgcatactg gggtactgtt aaagaatgat tacatggaag ttttggagac 780
ttgggaaaat gtgaagacgt tgatcatgcc tgaaaggaag agccttgagt tctgggttag 840
ttatgcaaag ggggagtgtt ataggttgga ggtccagttt ggtgacatta tagagacttg 900
tgggtgctct ttggaagatg aaaaacctgc actcctttta aaggtttgat ttttatgtta 960
cccttcttga aatgttttgt tatttttaca tccttttaat ttatgttgat tttagggctt 1020
gccaagagct aaggtgacca ctgacaagtg ctgggagctc agtgcctttt caatattgtg 1080
tgtatcagtt agtggcagag ccacagccaa tgaagggggt tcaattgaac cccctttgtt 1140
gaataattgt actgcataaa tggggcataa acaattcttt tgtgtatata taaatttatg 1200
aatcctctcg acataaggga agttttcatt gtagtggcaa aggtagttca aaaattgctt 1260
tagctcgcat gtttggattt ttttgaattc ctggctccgc cactgatatc tgtgtttgtt 1320
tatattagac ttccaataat agtgatacac tctcaaggtt tgaacaaaat ataaattgaa 1380
gagtaagagc tatttatagc tctgcaaatg gatttacaat gctttaagta agaagaaaga 1440
gggaatcagc acgaatccaa agcacacaat ctcactattc acagggatgg agtcctaata 1500
aaaaagttat caactggatt agtgtgtaac aatagaaact tctaatgtaa aagaatccgg 1560
gagttctatg gtgttaactc ccaaaacata taaccaactg agttttctta atgaacccaa 1620
tggttacatg cttctgctag ctggacgtac gacccatgca agctagtcaa aacctccctc 1680
ttccacttcc attttaaagt tgtgtcaagt tttccataag cacattttat gatttaggaa 1740
ggatgctagg gctaaccttt ataaagtggc ctatatgaag ttcctcttct tcctcacttg 1800
cacttgcact tgcagttgca cgttttcttt ttttgaaaat atccaattcg aaggagaagg 1860
gcattcttgg ttgtgtatgc aactaaaagt cagtcataag ttaaaataag ctgcaaagtc 1920
tgcagatcgt gagcgagctt tggggaagat atgatttaag agtgtgctgg gaaaacatag 1980
tactccgtat gttgttgtgt ctttcactat ataaaagaca ttttagactt ttattatata 2040
gcaagtcaag gatataatat agagagtcag aggtagaact tagatagaag aatcagtact 2100
gtgcagagca ttcttctgct gtattgaatt aaatcagata tcttttgatt tcttatgaaa 2160
cttgttttac agaatcatac agtttacaca gtctgtatgg tttctgaata gttagctgat 2220
cctaccaaaa gtctgtggca gctttgacta atgaacaagg gggttctgaa gtacttggat 2280
acagtttcag taaaagtctt aataataatt ttggggctaa taaggctatt ttcatggcag 2340
ggtaaattag acgggattgt gcatctgtcg cggatgcttc tgtcaccatt tgttctaaga 2400
acacattttt ttggtctaag aaaacattta ttatgcattg actagtctca gagtttaatt 2460
tcttccacta tatattgtct tatgtagaga acagaataaa gggataacag ttcttttatt 2520
gatgtatttg gtacatgcaa tggaaaataa caatagataa catcctatcc gagagattac 2580
tttatgaaaa aaatacacct atggcataac cttaaaaaga gaaacaaaaa tcccggagca 2640
aaccaaaaag aaaaggtgaa aatcctctga agggaaatgg agaaacatta tgcggtaatg 2700
aaatcttggc attgctgaat tttagattct ttaaccttta tttctgaggc aaagccaatt 2760
tctttgattt tcatttcagt gagtttttgc tttcagctaa aacatgcacc aaagctatac 2820
caaagagttt ctggacctgg tgttgcttca aagttcagtt ctgaccggta ccatgtttgc 2880
aaggaggatt gtgagttcct ttgggttcgc acaactgatt tttccgccat gaagtctatt 2940
ggatgctcat cctctctttg ttgggaaatc gaagacggat tgttaaattc agatttgctt 3000
tctagtttgc catattgtaa caatgatgtg atggatcttg ttctggatga agtaggagat 3060
atttattctg cttctgaatt agttcctctt gcaagtttcc catcagatct gaagctacca 3120
tatgagatcc ttttccagct taactctctc gtacactcac ataaaattag tcttggtgct 3180
gttaaaactg atcttattga agttcttagc aagttagaat tggacactgc aatgatgatc 3240
cttcagaaaa tgcataagtt gcagtcaacc tgtttcgagc ccgtgccatt catcaagaca 3300
cgcttgcatg tattgggtaa aaccagtaag aaccaacctt catcatctta cagcaggtta 3360
gtgaatcaaa acatgatgag tgttcacaga gtcttggtaa caccatcaaa ggtttactgc 3420
ctgggcccag agcttgaaac ctccaattac atcgtgaaga actttgcatc acatgcttct 3480
gatttcttga gagtaacttt tgtagaagag gattggagta aactttctcc taatgccatt 3540
tctatgagtg ttgaacaagg tatctttgca aagccttaca gaactaaaat ctatcatcgg 3600
attttgtcta tccttcgaga tggacttgat attggaacta aaaaatttct tttcctggcg 3660
ttctcggcta gtcagctacg ttcaaattcg gtttggatgt ttgcttccaa tgagtatgtc 3720
aaggcagaag atatcagaga gtggatgggc tgcttcaaca agattcgtag tgtctcgaaa 3780
tgtgctgcaa ggatgggtca gttgtttagc acctcttttc aaaccatgga ggtccaatcg 3840
ccgcatgttg agattcttcc agatattgaa gtaacctctg atggcgttag ttattgcttc 3900
tcagatggca ttggaaagat ttctcaagct tttgccagtc aagtagctca gaaatgtgga 3960
ttgagttata ccccatcagc atttcaaata cgatatggtg gttataaagg cgtgatagct 4020
gttgaccgca attcctttcg aaagctatct ctacggggca gtatgctcaa atttgaatca 4080
aagaacagga tgcttaatat taccaagtgg agtgatgcca tgccttgcta tctgaaccgg 4140
gagattgtta tcctcttatc tacgttggga gtggaggata aagtattaga agacctgcta 4200
gataatcatc tccatcttct gggcaagatg ttgaccacta atgaggcagc cttagacgtt 4260
ttggagagca taggtggggg tgacgtaaaa agaatcttaa tgaggatgtt gcaccaagga 4320
tatgcgccca atttggagcc ttatctctcg atgatgcttc aatcccattt tgagaatcag 4380
ctctcagacc taagaagtag gtgtcgtata ttcataccca aaggtcgagt tctagtagga 4440
tgcctagatg aaacaggtat attgaattat ggccaggttt atgcacgaat caccatgact 4500
aaggccgagc tacaaagtgg tcagcaaaat ttcttccagc aggtggatga aacaactgca 4560
gtagtaagag gcaaggttgt ggtaacaaaa aacccttgtc ttcatcctgg agatgtaaga 4620
gtacttgaag ctgtgtatga ggtggcattg gaggaaaagg cctgggtgga ttgcattatt 4680
tttcctcaga aaggtgaaag gtatagttta gatgctcagt atacgatatt tgagtagaaa 4740
atgttcagta tacggtagtt cagtgggact ttcatatcca aactatttta cttgacttga 4800
cttgtctgcc gtacactctg tccttttcta gtcttcatga agaccgatgg aaagtcttct 4860
tgcaaagttt tggatgttta atgataggac ataactgaaa ttaagtggct agtgctaata 4920
gattcaattt aatatttttg attagtacta atagcctaac cctactacct tgtggttgag 4980
gcattgcact ttttgttata aattatacta attactaaga tgttccagta gttgcgctgc 5040
atatcttatc ttctacagct ggagattcat gtattctatg atgttactaa tagtgttatt 5100
tcagaggtgt tcaggtagct ttgtctgtcc ataataacag ctctgagatc agatgaagct 5160
ataccacaaa ctttaaccta gtgtgtatat gcagttgcca gacttctgta atgaagaaga 5220
aacttttaat accattaggg agcttgcttg gcaactgaaa cattagtttt cgttaccctt 5280
tcacaaagac tgtctttcat gtttttcgtc ttaacatatt tcatcataat gttttagcat 5340
gtgtgaagag ttgaaaagag ttctgagcag agttggttag tcttggagca gaagtctgct 5400
ttcgacattt tccctttccc aacttattat ttttattgtg cttccacatc cctcctcctt 5460
aaccccttaa agggaaatta taatagatga agaaaacatt tctgagagaa aatcaagaac 5520
acttttaagt tctgtgtact gctcaaaggg gattaaatgt tcttttgagt actcaggagt 5580
attgaattgt catgtacagg cctcatccaa atgaatgctc cggtggtgat cttgatggag 5640
atctttattt cataagctgg gctgaaaacc tcattcctcg tcaaactgtg acacccatgg 5700
actacactgg gcgaagacct cgcataatgg atcacgaagt cactctagag gtagcttgaa 5760
ctatttcttc cacgagtgaa gaaacttgtt ttttttctga atacctctct gatttttggt 5820
ttctttcctg atttttgcag gaaattcaga gattctttgt tgattacatg attagcgaca 5880
ctcttggtgc tatctctact gcacatttgg ttcatgcaga tcgtgaacca gataaagctc 5940
tgaatccgaa atgcctccag ttagcaaccc ttcactctat ggctgtggac ttcgcaaaaa 6000
ctggagctgc agctgagatg cccaggtttc taaaaccaag agagtttcct gatttcttgg 6060
agaggtggga caaacccatg tatatatctg aaggtgtact agggaagctt tatcgtgcta 6120
tagtcaagtc ttctgttcgc ggtaactcag atgaccttgg ctctgtgaga gctatccaag 6180
atgcttatga tcatgacctt ttgttcgaag gttacgaggc attcatcgaa acagctaaaa 6240
atcacaaaga aatgtacttg gatagaatga acagcttact caactactat ggagcagaaa 6300
aagaggttga gatactgacg ggcaatttgc gccagaagtc tgtgtatttg cagcgggaca 6360
acaggaggta ttttgaacta aaagatcgaa tcttggtttc tgccaaaagc ctacagaagg 6420
aggtcaaagg gtggttcact ggttactgca aggaggatga gcataagaaa ttggcatcgg 6480
cgtggtatca tgttacttat catccttctt actgcgaagg aagtgctaat tgcctgggct 6540
ttccctgggt ggtaggtgac attttgctgg atataaagtt gcataatacc agaaaaatca 6600
cctcctagtt ctcaaccatg aaagatactt tatgcattgc ttgcccctat taacatgtgt 6660
aatcctgcct tactaaaaaa gatgtatagc cctgtgctta atgtagactt ttgacatttc 6720
ctgatggaag tgctcttgac ttaatctgca tccgacctaa caattagatg tcttagtgtt 6780
ttcggagcat agcaa 6795
<210> 71
<211> 4318
<212> DNA
<213> Artificial sequence
<220>
<223> N.tab-RDR6A exemplary contig Ntab-TN90_AYMY-SS110011
<400> 71
tattgtgtga acaagcaaat ccaaaagtac ttgtgactcg ttaaagaaaa gatgggatca 60
gagggctctg aaaaggatct cgtagtgact caaattagtg ttggtgggtt tgacaatgat 120
gtcaatgcga aaatgctttc agaatatctg gaagaacaag ttggacaagt atggagatgt 180
agattaaaga tttcagccac ccctcctgac tcttacccaa cttatgacat tgatgcagag 240
agggtgcata gaatgaaaga ttacgaaaaa gtggtacctc atgcattcgt tcattttgca 300
tcttcagagt ccgcaaagca tgctctggct gctgctgggg gtaatgagct catattagga 360
aagaagcctt tgattgttag tttgggacct gagaatccct atcgtctgaa tcagcggaga 420
agaactacca tgccctttag attttcagat gttagtgtag agttgggagt actggttagt 480
aaagatgact ttgtggttgg ttggagggga cctcgcactg gtgttgactt ttttgtggac 540
ccattcaacg gggcatgcag aatacttttc acaaaggata ctgctttctc tttcaggggt 600
gaagccagac atgccattat aaaatgcaat ttcaagattg agtttatggt aagggaaatc 660
aatgagataa agaaatgtaa agactttacg tctttggtaa tactgttgca gttggcttca 720
tctccattgg ttttctatag aactgctgat gatgatattg aagaatcagt tgcatttgac 780
ttgttagacg atgatgatca atggatccgt accacagaca ttacaggtag tggagccatt 840
ggtaggtgta atacctaccg tatttcaatt cgacctcgca atggtcctag ctttgagaag 900
gccatggcat atttcagttt tcgtagggtt cccatggtag aaatgtgtaa ccggaagatg 960
ctccgggtga gggacgagcc tgattttggg gtgtccatgt cagatccttt cttctgcttc 1020
caaaatgaag gtataagctt taaggtcatg tttctggtga atgcggtttt gcacaaaggc 1080
atagttaatc agcatcaaat gactaatgaa ttcttttact tacttagaag tcgtcaggag 1140
gaggttaatt tagctgcact gaagcacatg ttttcttaca aatggcctgt caatgatgct 1200
attcagaagt tagtaggcat ccagaaatgg ctgttgaaaa accctaaact tctcgagaga 1260
actggagagt tggatgatat tgtagaggtt aggagattgg ttatcacccc aaccaaagca 1320
tactgtcttc caccgactgt ggagctttcc aacagagtcc tcaggaatta taaacatgtt 1380
gcagatcgat ttttgcgagt tacattcatg gacgagggca tgcggaactt gaataggaat 1440
gtgctgacat actatgctgc taccattgtg agggaaatca catcaaattc gaatccccag 1500
agaactgcaa tcttccaaag ggtgaaaagt attctgagta aaggatttca tttgtgtggt 1560
cgaaagtact cctttttggc attctcagct aaccagctga gggatcgttc tgcctggttt 1620
tttgcagaag accctaaaat tagggtaccc ggcatcataa gctggatggg gaggttcagt 1680
aacaggaatg tcgccaaatg tgcagctagg atgggacagt gcttttcatc aacttatgca 1740
acagtggaag tcccttcaag ggaggttaac tcagagcttc cagatattga aagaaatggg 1800
tatgttttct ctgatggaat cggcatgata tcagcagatc tagctataga agttgcagag 1860
aagctgcatt taagtgtcaa ccctccttct gcttatcaga taaggtatgc tggttgtaaa 1920
ggtgttgttg cttgttggcc gacaaagaat gatggcatcc gcctttctct gaggccaagt 1980
atgaagaaat tcgactcaaa tcacactatc cttgaaatat gctcttggac gagatttcaa 2040
cctggtttcc tgaaccggca aatagtaacc ctgctctctt ccttggacgt taaagatgga 2100
atattctggg aaatgcaaaa agaaatgata tcagggttgg ataaaatgct cgtggattcg 2160
gacgtggctt ttgatgtcat cacagcttca tgtgctgagg caggaaatac tgcagctcta 2220
atgttgagtg caggttttaa acctcaaagt gagcctcatt taagagggat gctctctagc 2280
ataagagctt ctcagcttgg ggacctcagg aataaggcaa ggatatttgt tccttcggga 2340
aggtggttga tgggctgttt ggatgaatta ggtgagcttg agcaaggcca atgctttatt 2400
caagtgtcaa gcccttcttt ggagaattgt tttattaagc atggtccgaa attttctgat 2460
ataaagcaaa atcttcaagt agtaaagggc cttgttgtaa ttgcaaagaa cccgtgtctt 2520
catcctgggg atgtgaggat tctggaggct gtagatgttc ctggtttaca ccatctctat 2580
gattgtctgg tctttcctca gaagggggat aggccacatt caaatgaagc atcaggaagt 2640
gacctggatg gtgacctcta ctttgtgact tgggatgaaa atctcatccc acccagtaag 2700
aaaagctgga tcccgatgaa ctatgaacct gcggaagtca aacagttggg tcgtcaagtt 2760
aatcatatgg tagctacccg acaataatta tatttcttgc agctttggtt catatcttcc 2820
taattatttg gttagctttc agatgcttat acgtttgttt tgcaacataa tgttcatttg 2880
gttagaatgt tgatgaaata tttataagcc ttctagaaaa gctaccatta ctttttttag 2940
ctaatattta tatttaacaa ctgtttttat ttttgttgca caagtaagat atacttgttt 3000
ctcacttttc ttgtcttatg agccccaact tgacgcttct ctgatatgtg tattttcctt 3060
tttatggtaa gctgtttgca tttgatcata tttaagttgt ttagtttgtc cgtagttgat 3120
ttagttgtaa tagaagaggg agactctttt tctgttggca cactcgctag aaataaaaag 3180
ataaagctaa agacacttgc aaagatcttg tgctcttcat ggctcaaata tttgttctat 3240
caggctatat tcaaaaattt gcgcttgatt agaaatttaa gtctactttt tggaacttgt 3300
tattggttgg atcatttaac tggttgccta atattagttt attttttatt tttcacgcgc 3360
cgtatttatt cagttttaaa tatcttttgc tctgtttaca ggacataata gatttttttt 3420
caaaaaacat ggtccaagag agtctaggag aaatctgcaa cgcacatgtg gttcatgctg 3480
acctcagtga atttggagct ttggatgaga agtgcctaaa attggcagag cttgctgctc 3540
tagccgttga cttccccaaa actggaaaac ttgtgaccat gccgtttgac ctcaaaccaa 3600
aaatgtatcc cgacttcatg gggaaagagg aattccaatc atacaagtca aagaaaattt 3660
tgggcaaatt gtataggcaa gtgaaagatg tatgtgatac agagggtgaa gtatctgctg 3720
gacttgagct tgtcccaaac gacatcccat atgactctag tcttgagatc ccaggatcca 3780
cagctttcat agacgatgca tggaacagca aatgttctta tgatggtcag ttgcatggac 3840
ttttagggca atacaaagtt aacagggaag aagaggtggt tactggacat atatggtcca 3900
tgccgaagta cagtgctaag aagcaagggg aattaaaaga gaggctgaag cacgcatata 3960
atacgctgag gaaggagttc aggaatgtct tcgagcgtat ggatcctgat tttgatcttc 4020
ttcccgatga tgagaagaat gatatgtatg aaagaaaggc atctgcatgg tatcaggtca 4080
cctacaatcc tcattgggtt gctagatcac tggagttgca attgccagat gctatctcaa 4140
gtactgtaat gctaagtttt gcatggattg cagcagatta ccttgctcga attaaaatta 4200
ggcacagggg attgcagtat tccgactcta ccaagccaat caattccctt ggaaggtatc 4260
ttgttgacaa aatatgatac tcatcaactc tttggctgca aggcctctct gccattat 4318
<210> 72
<211> 1500
<212> DNA
<213> Artificial sequence
<220>
<223> N.tab-RDR6B exemplary contig Ntab-TN90_AYMY-SS48576
<400> 72
aatatttata agccttctag aaaagctacc attacttttt tagctaatat ttgtatttaa 60
caaatgtttt tatttttgtt gcacaagtaa gatatacttg ttgctcactt ttcttgtctt 120
atgagcccca acttgatgct tctctgatat gtgtattttc ctttttatgg taagttgttt 180
gcatttgatc atatttaagc tgtttggttt gtccgtaatt gatttagttg taatagaaga 240
gggagactct ttttctgtcg gcacactcgc tagaaataaa aagataaagc aaaagacact 300
tacaaagatc ttgtgctctt catggctcaa atatttgtga ttatttgtgc tatcaggcta 360
tattcaaaac tttgcgcttg attagaaatt taagtctact ttttggaact tgttattggt 420
tggatcattt aactggttga ataatattaa tttatgtttt atttttcaca tgtggtattt 480
attcagtctt aaatatcttt tgctctgttt acaggacata atagattttt tttcaaaaaa 540
catggtccaa gagagtctag gagaaatctg caacgcacat gtggttcatg ctgacctcag 600
tgaatttgga gctttggatg agaagtgcct aaaattggca gagcttgctg ctctagccgt 660
tgatttcccc aaaactggaa aacttgtaac catgcctttt gacctcaaac caaaaatgta 720
tcccgacttc atggggaaag aggaattcca atcatacaag tcaaagaaaa ttttgggcaa 780
attgtatagg caagtgaaag atgtatgtga tgcagagggt gaagtatctg ctggacttga 840
ggttgtccca aaagacatcc catatgacac tactcttgag atcctaggat ccacaacttt 900
catagacgat gcatggaaca gcaaatgttc ttatgatggt cagttgaatg gacttttagg 960
acaatacaaa gtgaacaggg aagaagaggt ggttactgga tatatatggt ccatgccgaa 1020
gtacagtgct aagaagcaag gagaattaaa agagaggctg aagcacgcat ataatatgct 1080
gaggaaggag ttcaggaatg tcttcgagcg tatggagcct gattttgatc ttcttcctga 1140
tgatgagaag aatgatatgt atgaaagaaa ggcatctgca tggtatcagg tcacctacca 1200
tcctcattgg gttgctagat cactggagtt gcaattggca gatgctgtct caaatactgt 1260
aatgttaagt tttgcatgga ttgcagcaga ttaccttgct cgaattaaaa ttaggcacag 1320
gggattgcag tattccgact ctaccaagcc aatcaattcc cttggaaggt atcttgttga 1380
caaaatatga tgctcatcaa ctctttggct gcaaggcctc tctgccatta tcaatacctg 1440
gtttgatgtc ctttagaacc tcctaatctc ctgtttcctt atgttgatct gttattatat 1500
<210> 73
<211> 1512
<212> DNA
<213> Artificial sequence
<220>
<223> N.tab-RDR6C exemplary contig Ntab-TN90_AYMY-SS1589
<400> 73
aatatttata agccttctag aaaagctacc attacttttt tagctaatat ttgtatttaa 60
caactgtttt tatttttgtt gcacaagtaa gatatacttg ttgctcactt ttcttgtctt 120
gtgagcccca acttgatgct tctctgatat gtgtattttc ctttttatgg taagttgttt 180
gcatttgatc atatttaagc tgtttggttt gtccgtaatt gatttagttg taatagaaga 240
gggagactct ttttctgtcg gcacactcgc tagaaataaa aagataaagc aaaagacact 300
tacaaagatc ttgtgctctt catggctcaa atatttgtga ttatttgtgc tatcaggcta 360
tattcaaaac tttgcgcttg attagaaatt taagtctact ttttggaact tgttattggt 420
tggatcattt aactggttga ataatattaa tttatgtttt atttttcaca tgtggtattt 480
attcagtctt aaatatcttt tgctctgttt acaggacata atagattttt tttcaaaaaa 540
catggtccaa gagagtctag gagaaatctg caacgcacat gtggttcatg ctgacctcag 600
tgaatttgga gctttggatg agaagtgcct aaaattggca gagcttgctg ctctagccgt 660
tgatttcccc aaaactggaa aacttgtaac catgcctttt gacctcaaac caaaaatgta 720
tcccgacttc atggggaaag aggaattcca atcatacaag tcaaagaaaa ttttgggcaa 780
attgtatagg caagtgaaag atgtatgtga tgcagagggt gaagtatctg ctggacttga 840
ggttgtccca aaagacatcc catatgacac tactcttgag atcctaggat ccacaacttt 900
catagacgat gcatggaaca gcaaatgttc ttatgatggt cagttgaatg gacttttagg 960
acaatacaaa gtgaacaggg aagaagaggt ggttactgga tatatatggt ccatgccgaa 1020
gtacaatgct aagaagcaag gagaattaaa agagaggctg aagcacgcat ataatacgct 1080
gaggaaggag ttcaggaatg tcttcgagcg tatggagcct gattttgatc ttcttcctga 1140
tgatgagaag aatgatatgt atgaaagaaa ggcatctgca tggtatcagg tcacctacca 1200
tcctcattgg gttgctagat cactggagtt gcaattggca gatgctgtct caaatactgt 1260
aatgttaagt tttgcatgga ttgcagcaga ttaccttgct cgaattaaaa ttaggcacag 1320
gagattgcag tattccgact ctaccaagcc aatcaattcc cttggaaggt atcttgttga 1380
caaaatatga tgctcatcaa ctctttggct gcaaggcctc tctgccatta tcaatacctg 1440
gtttgatgtc ctttaggacc tcctaatctc ctctttcctt atgttgatct gttattatat 1500
gtaatttgtt cc 1512
<210> 74
<211> 4209
<212> DNA
<213> Artificial sequence
<220>
<223> DCL2A Cdna
<400> 74
atggatccaa ctgaagttac agtctctgaa aaccaacagc tctgcgctgt ctctctgcct 60
tttgcaagaa gttatcagtt agaggcattg gagacggcat taaagcagaa cactattgtt 120
tatttggaga ctggttcggg aaagaccctt atcgctatta tgcttctgag aagctatgct 180
taccttcttc gaaagccgtc tccctacata gctgttttct tggtcccgac tgttgttttg 240
gtggctcagc aaggagatgc tctcattatg catactgact tgaaagtggg caagtattgg 300
ggagaaatgg gtgtcgatta ttgggatgct gctacatggc aacaacaggt ggacaatcat 360
gaggtgctgg taatgacacc cgcaatacta cttgctgctt tgaggcatag cttcttaaaa 420
attgaaatga tcaaagttct aatatttgat gaatgtcaca atgcacgagc caaacaccct 480
tatgcctgca taatgaagga attttatcat cgtcaattaa ccctcgaaag tgcacaactt 540
ccgagaatat tgggaatgac tgcttcccct ataaagacta aaggttctag cgcggaattt 600
acttggaaaa tgattcgtga cctcgagaac cttatgaatt ccaaggtata cacgtgtgtc 660
agtgaatctg ttttggccga gtatatccca ttctcaactc caaagctgaa gatatatcaa 720
catgtggata ttccgtgcac attgtttgtt agtttagttt ctgacctgat aaggttgaaa 780
gacaagtatg aagattcgat ttcaaaatcg agcctatctg atttaagtgc tggttctgca 840
aaaaaaagat tgtcaaaact atattcgtcc ttcgtatttt gtttgagtga gctgggtgtt 900
tggccggctt tcaaggcagc cgagttcttg tcctctgaag aaagcgactt cttttcatgg 960
ggagaattag atgtttgtgc tcaaacgatt gttagaaatt tcagtttggg tgcatctaag 1020
gtcttctcgg ctcgcatacc atctggttct cattggtcac ttggtggtga tattcatgca 1080
aatgttgatg ctggatattt gacatccaaa attaatagtc ttatagagtc tcttcttgag 1140
tacagagacc tgaaggattt gagatgcatc atatttgttg agagaatcat tacagctatt 1200
gttcttcggt ctttgttaaa tgagttgctt ccggaattaa gtggttggaa aactgagtac 1260
actgcaggac atagttctat gctgcagtca cagagcagaa atgttcaaaa taaaattgtt 1320
gaagaatttc gcaagggtgt ggtcaacatt attgtagcga cttctattct tgaagagggt 1380
ttggatgttc aaagttgcaa ccttgtcatt cgatttgatc cctcagcaac cgtttgtagc 1440
tttatacagt ctcgtggtcg agctcgaatg cagaactcac actttattat gatggttggg 1500
agcggggatg cttcaactct cactcgcatg caaaattata tgaaaagtgg ggagatcatg 1560
cggcaagaat cattacgcaa tgcttctatt ccgtgttcac ctcttgatga tgaattgcac 1620
aatgaacctt gctataaagt tgaaacaact ggagcagttg tcaccctcag ttctagcgtg 1680
tcattgttat acttctattg ctcaaggcta ccttcggatg ggtactataa acccagtcct 1740
aggtgtgtta ttgaggagga aacagaaacc tgcaccctac atcttcccaa aaattgccca 1800
ctgcaaaaag ttattagtgt gaaagggaat accaaaatat tgaagcaact tgcttgcctt 1860
gaagcttgta aagaacttca tcgtgagggt gcattgaccg acaatcttgt tcctgatatc 1920
gtggaggaag aagccatcat caaagaattg ggatgtcaaa tctatactga tgaagaatca 1980
aagtactttc caccagaatt ggttagtcat tgtgccaatg atacagaagc agtgtactac 2040
tgctacgtag ttgatttgca acatgactct tacagcaatt accagcttcg tgggataata 2100
cttgctgtta ggacaaggct caagttagac gatgaaagat tgatttttga cttggatgtt 2160
gataatggaa gcttgctagt tcaagtaaat tatagtggag ttgttaggct tacgtctgaa 2220
gagattttac gatgtcagag gtttcaagtc agtctattca gaattcttct tgaccgcgat 2280
ctgagtaagc tgcaggacgc tttggctgca gttcaactgc ctgttggttc tgcagtttct 2340
gattatcttt tgcttccatc tttgggttca actcaaaacc ctcaaataaa ttgggaatgt 2400
gtgaattctg tgctgtttcc ttctcaagtt cttggggata agcatattga ttgttgttct 2460
acacaaggtc gcaaacgcag tgtgaacatc aaaactgggg tggtatgcag ctgcatgttg 2520
gagaactcat tggtctgtac gcctcataat ggctatgtgt actgcattac cggttttttg 2580
gataatttag attgcaactc attgctggaa cagagaactg gagaatccat tacctacaaa 2640
gaatactaca aaaagcggca tgggatcaac ttatgctttg aaggagaacc acttcttagg 2700
gggaaacgcc ttttcaaagt gcacaattac cttcaaagat gcagaagtca gaaggctaaa 2760
gattcaactg attcatctgt tgaattgccc cctgaacttt gttccatcat catgtcacct 2820
atctctattt ctacccttta tacctattca tatgttcctt cggtcatgca tcggattgag 2880
tcattggtta tggcctcaaa cttgaaaagg atgcactcgg atcagtgcac gcaaaacatt 2940
tttattccaa ccgctaaggt tctggaggca attactacaa agaaatgcgt tgaaaagttt 3000
catttggaat cacttgagac acttggagac tcttttctca aatatgctgc gagtatacag 3060
ctgttcaaga cttatgaaaa tcatcacgag ggtctactca ctgttaagaa aaacaaaatt 3120
atttccaatg ctgcattgtg caagcttgga tgtgctcgta aaataccggg atttattcgt 3180
aatgagccat tcgatcttaa aggatggctc attcctggtg ataattctca agttcgcaat 3240
ttcgatgaag aagtgctgat gccttctgta aaaatgtata gtaggggaag gcagaagatt 3300
aaaagtaaga gagtagctga tgttgttgaa gcactgatag gtgcctttct cagctcaggt 3360
ggtgaagtag cggctttgtc atttatgaaa tggcttggga tcgacattga ttttgtagct 3420
gcacctacgc tgaggcactt ccccatgaat gctgagaagc tagttaatat tcgatacttg 3480
gaatcactgc tagattacaa gttccatgat ccttctctgc ttgttgaagc tctaactcac 3540
ggatcttaca tgctacctga gattccacga tgctatcagc gcttggaatt tcttggagat 3600
gcagtgctag attatgctgt cacagcgcat ctctatttca aatatccggg actgtctcca 3660
ggactcatta ctgatttgag gtctgcctcc gtaaataatg aatgctacgc tcaggctgct 3720
gttaaggctg gcctacacaa gcacattctt catgcttcac aagatctgca gagacagatg 3780
gttaatactg ttctgaattt tgagaaattg gatcccgtgt ccacgttcgg atgggagtcc 3840
gaaactactt ttccaaaggt gcttggagat gttattgagt ctcttgccgg ggcaatcttt 3900
gttgattctg gcttcaacaa agatgttgtg tttcagagca tacgaacact tctggaaccg 3960
ttgattacac cggatacagt aaagctccat ccaatcagag agttaagtga actatgtgac 4020
cagaaaggtt atataaagaa gaagaacgtt gtctctcgtg agaatggtgt ggcgtatatt 4080
acagtagagg ttgaagcaga tggtgttagt cacaagttca cgtgctcgga acgagacaaa 4140
aaaatggccg agaaggtggc ttgcaaaaat gtactcaaat tgctgaagga atgtgcatct 4200
gatgcttag 4209
<210> 75
<211> 4209
<212> DNA
<213> Artificial sequence
<220>
<223> DCL2B Cdna
<400> 75
atggagccag ctgaagttac agtctctgaa aaccaacagc tctgccctga ctctctgcct 60
tttgcaagaa gttatcagtt agaggcattg gagacggcat taaagcggaa cactattgtt 120
tatttggaga ctggttctgg aaagaccctt attgctatta tgcttttgag aagctatgct 180
tatcttcttc gaaagccttc tccatacata gctgttttct tggtcccgac ggttgttctg 240
gtggctcagc aaggagatgc tctcatcatg cataccgact tgaaagtggg caagtattgg 300
ggagaaatgg gtgtcgatta ttgggatgct gctacatggc aaaaacaggt ggacgatcat 360
gaggtcctcg taatgacacc cgcaatacta cttgctgctt tgaggcatag tttcttaaaa 420
attgaaatga tcaaagttct aatatttgat gaatgtcaca atgcaagagg caaacaccct 480
tatgcctgca taatgaagga attttatcat cgtcaattca cccttgaaag cgcacaactt 540
ccaagaatat tcggaatgac tgcttcccct ataaagacta aaggttctag cgcggaattt 600
acttgggaaa tgattcgtga cctcgagaat cttatgcatt ccaaggtata cacatgtgtc 660
agtgaatctg ttttggcaga gtatatccca ttctcaactc cgaagctgaa gatatatcaa 720
catgtggata ttccgtgcac attgtttgtt agtttagttt ctgacctgat aaagttgaaa 780
gacaagtatg aagatttgat ttcaaagtca agcctatctg atttaagtgc tggttctgca 840
agaaaaagat tgtcaaaact atattcgtcc ttcatatttt gtttgagtga gctgggtgtt 900
tggctgactt tcaaggcagc cgagttcttg tcctctgaag aaaccgactt cttttcatgg 960
ggagaattag atgtttgtgc tcaaacgatt gttagaaatt tcagtttggg tgcatctaag 1020
gttttctcgg ctcgcatacc atctggttca cattggtcac ttggtggtga tattcatgca 1080
aatgttgatg ctggatattt gacatccaaa gttaatagtc ttatagagtc tcttcttgag 1140
tacagagacc tgaaggattt gagatgcatc atatttgttg agagaatcat tacagctatt 1200
gttcttcggt ctttgttaaa tgagttgctt ccggaattaa gtggttggaa aactgagtac 1260
acagcaggac atagttctat gctgcagtca cagagtagaa atgttcaaaa taaaattgtt 1320
gaagaatttc gcaagggtgt ggtcaacatt attgtagcga cttctattct tgaagagggc 1380
ttggatgttc aaagttgcaa ccttgtcatt cgatttgatc cctcagcaac cgtttgtagc 1440
tttatacagt ctcgtggtcg agctcgaaag cagaactcac actttattct gatggttggg 1500
agcggggatg catcaactct tactcgcatg caaaattata tgcaaagtgg ggagatcatg 1560
cggcaagaat cattacgcca tgcttctatt ccgtgttcac ctcttgatga tgaattgcaa 1620
aatgaattgc actataaagt tgaaacaact ggagcagttg tcaccctcag ttctagcgtg 1680
tcattgttat acttctattg ctcaaggcta tcttcggatg ggtactataa acccagtcct 1740
aggtttgtta ttgagaagga aacagaaacc tgcaccctac atcttcccaa aaattgccca 1800
ctgcaaaaag ttattagtgt gaaagggaat accaaaatat tgaagcaact tgcttgcctc 1860
gaagcttgta aagaacttca tcgtgagggt gccttgaccg acaatcttgt tcctgatatc 1920
gtggaggaag aagccatcat caaagaattg ggatgtcaaa tctctaccga tgaagaatca 1980
aagtactttc caccagaatt ggttagtcat tgtgccaatg atacggaaac agtgtactac 2040
tgctacgtag ttgatttgca acatgactct tacagcagtt accagcttcg tgggatagta 2100
cttgctgtta ggacaaggct caagtttgac gatgaaagac tgacttttga cttggatgtt 2160
gataagggaa gcttgctagt tcaagtaaat tatagtggag ttgttagact tacttctgaa 2220
gagattttac gatgtcagag gtttcaagtc agtctattca gaattcttct tgaccgcgat 2280
ctgagtaaac tgcaggacgc tttggctgca gttcaactgc ctgttggttc tgcagtttct 2340
gattatcttt tgcttccatc tttgggttca actcaaaacc ctcaaataaa ttgggaatgt 2400
gtgaattctg tgctatttcc ttctctagtt cttggggata agcatattga ttgttgttct 2460
acgcaaggtt gcaaacgcag tgtgaacacc aaaactgggg tggtatgcag ctgcatgttg 2520
gagaactcat tggtctgtac gcctcataat ggctatttgt actgcgttac cggtttcttg 2580
gataatttgg attgcaactc attgctggaa cagagaactg gagaatccgt tacctacaaa 2640
gaatactaca aaaagcggca tgggatcaac ttatgctttg aaggagaacc acttcttagg 2700
gggaaacgca ttttcaaagt acacaattac cttcaaagat gtagaagtca gaaggctaaa 2760
gattcaactg attcatctgt tgaattgcct cctgaacttt gttccatcat catgtcacct 2820
gtctctattt ctacccttta tacctattca tatcttcctt cggtcatgca tcgggttgag 2880
tccttgatta tggcttcaaa cttgaaaagg atgcactcag atcagtgcac tcaaaacatt 2940
tttattccaa ctgctaaggt tctggaagca attacaacaa agaaatgcgt cgagaagttt 3000
catttggaat cacttgagac acttggagac tcttttctca aatatgctgc gagtatacag 3060
ctgttcaaga cttatgaaaa tcatcacgag ggtctactca ctgtgaagaa aaacaaaatt 3120
atttccaatg ctgcattgtg caagcttgga tgtgctcgta aaataccggg attcattcgt 3180
aatgaaccat tcgatcttaa agggtggctc attcctggtg ataattccca agttcacaat 3240
ttcgatgaag aagtgctgat gccttcagta aaaatgtata gtaggggaag gcagaagatg 3300
aaaagtaaga gggtagctga tgttgttgag gcactgatag gtgccttcct cagctcaggc 3360
ggggaagtag cggctttgtc atttatgaaa tggcttggga tcggcattga ttttgtagat 3420
gcaccttcgc cgaggcactt ccctatgaat gctgagaagc tagttaatgt cagatacttg 3480
gaatcactgc tacattacaa gttccatgat ccttctctgc ttgtagaggc tctaactcac 3540
ggatcttaca tgctacctga gattccacga tgctatcagc gattggaatt tcttggagat 3600
gcagtgctag attatgctgt tacagcgcat ctgtatttca aatatccggg actgtctcca 3660
ggactcatta ctgatttgag gtctgcctcc gtaaataatg aatgctacgc tcaagctgct 3720
gttagggctg gcctacacaa gcacattctt catgcttcac aggatctgca gagacagata 3780
gttaatactg ttctgaattt tgagaaactg gatccggtgt ccactttcgg atgggagtcc 3840
gaaactactt ttccaaaggt gcttggagat gttattgagt ctcttgccgg ggcgatcttt 3900
gttgattctg gcttcaacaa agatattgtg tttcagagcg tacgaacact tctggaaccg 3960
ttgattacac cggatacagt aaagctccat ccagtcagag agttgagtga actatgtgac 4020
cagaaaggtt atataaagaa gaagaatgtt gtctcacgtg tgaatggcgt ggcgtatatt 4080
acagtagagg ttgaagctga cggtgttagt cacaagttca cgtgctcgga acgagacaaa 4140
aaaatggccg agaaggtggc ctgcaaaaat gtactcaaat tgctgaagga atgtgcatct 4200
gatgcttag 4209
<210> 76
<211> 4065
<212> DNA
<213> Artificial sequence
<220>
<223> DCL4A Cdna
<400> 76
atggaaggcg gcgactttga gaacggcact gagagtccac caagtgctgc aacttcaccg 60
atcactgagc agctttctgc tctgtctctc aatggcgaca tagattctcc tgtttcagtt 120
cagaaaccag agaaagaccc cagaaaaatt gctagaaagt atcagatgga tctttgtaaa 180
aaagcattag aggagaatgt tgttgtatat ctgggaacgg gctgtgggaa aactcatatt 240
gccgtcttgc ttatctatga gatgggacag ctgataagga aaccccagaa gagcatttgc 300
gtgtttcttg ctcccactgt ggcgttggtg caacagcaag ccaaggtcat agaagactct 360
attgacttca aagttgggac atactgcggg aaatccaagc atttgaagag ccacgaagac 420
tgggaaaaag aaatggaaca gtatgaggtc cttgttatga cccctcaaat actattacat 480
aatctttccc actgctatat caggattgaa tttattgctc ttctgatctt tgatgagtgc 540
cactatgcac aagttgagag tgatcatcct tatgctgaga ttatgaagat attttacaaa 600
cctgatgtag taaaactgcc ccgtatactt ggcatgactg catctccaat atcaggaaaa 660
ggtgctactg ttgaaggcct tgagacctta cttcgctcta aggtgtattc tgttgaagac 720
aaggatgaac tggaacagtt tgttgcatca cctaaggtga atgtatacta ctatggtcct 780
ggcgccgcgt gtcttactaa agcttactct cagaagcttg aagagataaa acaccagtgt 840
gtgatggtgc ttcacaagaa agcagttgat catagcacac tcaggaacac aaaaaagatg 900
ctcaagagat tgcatggaca tctaattttt tctctggaaa acctaggtgt ctttggggca 960
ttacaggcta gttgcatcct cttaaagggg gatcactatg agcgccatca aatggtggaa 1020
gctgatgtta atgctagtga tgactctttg tgtgacagat atctgagtca ggtcgccaca 1080
atgtttactt ctggttgtgc taaagatggt atgaatcctg atttgacact tgtggaagtt 1140
ctgaaggagc cttatttctc caaaaagctt ttacgtctaa ttggaatcct ttccaacttc 1200
ggggtacaac cagatatgaa gtgcataatt ttcgtcaata ggatcgtgac tgcgagatct 1260
ctttcttata tgcttcagca tctgaaagtt ttatcttctt ggaaatgcgg gtttcttgta 1320
ggagtgcact caggattgaa gagtatgtca cgaaaaaata caaatatcat tctcaataag 1380
ttccgttctg gtgagctcaa cttattggtt gccaccaaag ttggcgagga aggacttgat 1440
atccagacat gctgccttgt tatacgattt gatcttcctg aaactgttgc cagttttata 1500
cagtctagag ggcgtgcccg catgccaaag tctgaatatg catttttggt tgatagtgat 1560
aaccaaaggg agcttaattt gattgagcat ttttcaagaa atgaagctcg gatgaatgat 1620
gagatttctt ccaagaaatc ttgcacgaca gttatagatt ttcaagaaaa tatatacaaa 1680
gtagatatga ctggtgcaac catcagttct gcatcaagca tttcgttgct tcaccattat 1740
tgttccaagc ttccacgtga cgagtttttc tgccccaagc cgcagttctt ctactttgat 1800
gacatagatg gaactatttg caaattagtt ttgccttcaa acgctccaat gcatcaaatt 1860
gtgagtgctc ctcaatcttc tatagaagca gctaagaaag atgcctgttt aagagcctgc 1920
aagagcttgc atgaacttgg agcactcact gattatcttt tgccggatca agcagatgaa 1980
gacctgattc acgttttttc tgactcagaa agctcagatg gcgaagacgc acgagaagag 2040
ctccatgaga tgattgttcc cgctgccttt aaagaaccat ggactgagac agagagtcct 2100
gtttgcctta actcgtacta catcaacttt tcaccttgtc caattgatag ggtttataaa 2160
aagtttggcc tatttttgaa agcacctctt ccccaagagg ctgagagaat gaaacttaat 2220
ctcaacttgg ctcgaggtag atctgtagag acagagctta ttccatcagg agctactaat 2280
tttgagaaca atgagcaggt acaactagca gagaagttcc agagaatgtt cctcaagatc 2340
attcttgacc gctctgagtt catttcagaa ttcgtatctt tggaaaaaca agattatgtt 2400
gactcagctt caaaatctta cctacttctt ccactcaatt tatgtggaca caataaaatt 2460
tccgtggact gggagcttgt cagaagatgc ttgtcatcac caatttttgg gacttcagta 2520
tatgcaggca atagtgagat atccaaattt gatgagcagt tgcaacttgc caatggttcc 2580
aaaagcgtac atgatgttgc caatagtttg gtatatgttc catgcaagga tacatttttc 2640
ttcatatctg atgttgtcaa agaaagcaat gcatacagca tatataaaga ttcaaaaaac 2700
catgtcaaac actattatga tacttttggt atccatcttt cgtaccctga gcaaccacta 2760
ataaaagcaa aacaactctt ctgtttggac aacttgctac gaaagaaagg ctattcagag 2820
ttgcgtgata aagaggagca ctttgttgaa ctacctgctg aaatttgcca gctcaagata 2880
attgggtttt ccaaagatat tgggagctca ttatcactgt tgccatcgat catgcatcgt 2940
cttgaaagcc tacttgtcgc tattgaacta aagggctgcc tatctgcttc tttccctgag 3000
ggaagggaag taacaataga tcatgttctt gaagcactta ctacagagaa atgcaatgaa 3060
cctttttctc ttgaaaggct tgaagtgctt ggtgatgcat ttctcaagtt tgcagttggg 3120
aggcatgtct ttcttacata cgatgccttt gacgaaggac agttaactag aaggcgctca 3180
aacattgtga acaattccta tctgtacacg atagcagtca gaaacaattt acaggcattt 3240
attcgtgatc aatcatttga tcccaaccac ttctatgcag taggccgtcc gtgccctgta 3300
atctgtgaca aacaaacaga aaaaaacata cacggtcaat gtggtagtgt aacagatggt 3360
gcaaagactg aagttaggtg tagcaaatgt catcagtggt tgcgtaagaa aacaattgct 3420
gatatagttg aagcccttgt tggcgctttt atagttgaca gtggcttcaa agcagcaatt 3480
gcatttctta aatggattgg tatctataca gatttcgaag aatcacaagt aaagagtatt 3540
tgcgctgcaa gcaaagtctt tatgccactt gctgatgaaa ttgatattcc ggccattgaa 3600
aatttattag gttatccatt cgtccataag ggtttgctca ttcaggcctt catccatcca 3660
tcttataaca accacggagg aggttgctat cagagactgg agtttcttgg agatgctgtc 3720
ctcgattatt tgatcacatc ctatctatac tctgtgtacc caaaactgaa gcctggccag 3780
ttgactgatc tgagatcagt ttctgtaaac aacaacacct tcgcagttgt tgcagtacat 3840
caaagcttcc acagccatat actctgtgat tatagtagtg gcctccgtga gtcaattact 3900
agatatgtca atttcattgg aagaccagat tctatgaaaa ggttggctga agagccatct 3960
tgtccaaagg tattcactat ttacatgatg aaatcttcga tattgatgga ttcatggagt 4020
ttcttataca gagtttataa tagtttgtgt ttacacttat tgtag 4065
<210> 77
<211> 4794
<212> DNA
<213> Artificial sequence
<220>
<223> DCL4A Cdna
<220>
<221> misc_feature
<222> (4705)..(4705)
<223> n is a, c, g, or t
<400> 77
atggaaggcg gcgattttga gaacgacact gagagtccac gaagtgctgc aacttcaccg 60
atcactgagc agctttctgc tctgtctctc aatggcgaca cagattcccc tgtttcagtt 120
cagaaaccag agaaagaccc cagaaaaatt gctagaaagt atcagatgga tctttgtaaa 180
aaagcattag aggagaatgt tgttgtatat ctgggaacgg gctgtgggaa aactcatatt 240
gccgtcttgc ttatctatga gatgggacag ctgataagga aaccccagaa gagcatttgc 300
gtgtttcttg ctcccactgt ggcgttggtg caacagcaag ccaaggtcat agaagactct 360
gtcgacttca aagttgggac atactgcggg aaatccaagc atttgaagag ccacgaagac 420
tgggaaaaag aaatggaaca gtatgaggtc cttgttatga cccctcaaat actattacat 480
aatctttccc actgctatat caggattgaa tttattgctc ttctgatctt tgatgagtgc 540
cactatgcac aagttgagag tgatcatcct tatgctgaga ttatgaagat attttacaaa 600
cctgatgtag taaaactgcc ccgtatattt ggcatgactg catctccaat atcaggaaaa 660
ggtgctactg ttgaaggcct tgagacctta cttcgctcta aggtgtattc tgttgaagac 720
aaggatgaac tggaacagtt tgttgcatca cctaaggtga atgtatacta ctatggtcct 780
ggcaccgcgt gcctaactaa agcttacttt cagaagcttg aagagattaa aagccagtgt 840
gtgatggtgc ttcacaagaa agcagctgat catagcactc tcaggaacac aaaaaagatg 900
ctcaagagac tgcatggaca tctaattttt gctagttgca tcctcttaaa gggggatcac 960
tatgagcgcc atcaaatggt ggaagctgat gttaatgcta gtgatgactc tttgtgtgac 1020
agatatctga gtcaggtcgc tgcagtgttt acttctggtt gtgctaatga tggtatgaat 1080
cctgatttgg caattgtgga agttctgaag gagccttatt tctccaaaaa gcttttacgt 1140
ctaattggaa tcctttccaa cttcggggta caaccagata tgaagtgcat aatttttgtc 1200
aataggatcg tgactgcgag atctctttca tatatgcttc agcatctgaa agttttatct 1260
tcttggaagt gtgggtttct tgtaggagtg cactcgggat tgaagagtat gtcacgaaaa 1320
aatacagata tcattctcaa taagttccgt tctggtgagc tcaacttatt ggttgccacc 1380
aaagttggcg aggaaggact tgatatccag acatgctgcc tcgttatacg atttgatctt 1440
cctgaaactg ttgccagttt tatacagtct agagggcgtg cccgcatgcc aaagtctgaa 1500
tatgcatttt tggttgatag tgataaccaa agggagctta atttgatcga gcatttttca 1560
agaaatgaag ctcggatgaa tgatgagatt tcttccagga aatcttgcac gacagttata 1620
gattttcagg aaaatatata caaagtagat atgactggtg caaccatcag ttctgcatca 1680
agcatttcgt tgcttcacca ttattgttcc aagcttccac gtgacgagtt tttctgcccc 1740
aagccgcagt tcttctactt tgatgacata gatggaacta tttgcaaatt agttttacct 1800
tcaaatgctc caatgcatca aatcgtgagt gctcctcaat cttctataga agcagctaag 1860
aaagatgcct gtttaagagc ctgcaagagc ttgcatgaac ttggagcact cactgactat 1920
cttttgccgg atcaagcaga tgaagatgaa gacctgattc atggtttttc tgactcagaa 1980
agctcagatg gcgaagatgc acgagaagag ctccatgaga tgattgttcc cgctgccttt 2040
aaagaaccat ggactgagac agagagtcct gtttgcctta actcgtacta cattaacttt 2100
tcaccttgtc caattgatag ggtttataaa aagtttggcc tatttctgaa agcacctctt 2160
ccccaagagg ctgagagaat gaaacttgat ctcaacttgg ctcgaggtag atctgtagag 2220
acagagctta ttccatcagg agctactaat tttgagaaca atgagcaggt acaactagca 2280
gagaaattcc agagaatgtt cctcaagatc attcttgacc gctctgagtt catttcagaa 2340
tttgtatctt tggaaaaaca agattctgtt gactcagctt caaaatttta cctacttctt 2400
cccgtcaatt tatgtggaca caataaaatt tccatagact gggagcttgt cagaagatgc 2460
ttgtcatcac caatttttgg gacttcagta tatgcaggca atagtgagat atccaaattt 2520
gatgagcagt tgcaacttgc caatggttcc aaaagcgtac atgatgttgc caatagtttg 2580
gtatatgttc catgcaagga tacatttttc ttcatatctg atgttgtcaa agaaagcaat 2640
gcatacagca tatataaaga ttcaaaaaac catgtcaaac actattatga tacttttggt 2700
atccatcttt cgtaccctga gcaaccacta ataaaagcaa aacaactctt ctgtttggac 2760
aacttactac gaaagaaagg ctattcagag ttgcgtgata aagaggagca ctttgttgaa 2820
ctacctgctg aaatttgcca gctcatgata attggatttt ccaaagatat tgggagctca 2880
ttatcactgt tgccatcgat catgcatcgt cttgaaagct tacttgtcgc tattgaactt 2940
aagggctggc tatctgcttc tttccctgag ggaagggaag taacaataga tcatgttctt 3000
gaagcactta ctacagagaa atgcaatgaa cctttttctc ttgaaaggct tgaagtgctt 3060
ggtgatgcat ttctcaagtt tgcagttggg aggcatgtct ttcttacata cgatgccttt 3120
gacgaaggac agttaactag aaggcgctca aacattgtga acaattccta tctgtacacg 3180
atagcagtca gaaacaattt acaggcattt attcgtgatc aatcatttga tcccaaccac 3240
ttttatgtag taggccgtcc gtgccctgta atctgtaaca aacaaacaga aaaaagcata 3300
cacggtcaat gtggtagtgt aaccgatggt gcaaagactg aagttaggtg tagcaaatgt 3360
catcagtggt tgcgtaagaa aacaattgct gatatagttg aagcccttgt tggcgctttt 3420
gtagttgaca gtggcttcaa agcagcaatt gcatttctta aatgtattgg tatctataca 3480
gatttcgaag aatcacaagt aaagagtatt tgcgctgcaa gcaaagtctt tatgccactt 3540
gctgatgaaa tagatattcc tgccattgaa aatttattag gttatccatt cgtccataag 3600
ggtttgctca ttcaggcctt catccatcca tcatataaca accacggagg aggttgctat 3660
cagagactgg agtttctcgg agatgctgtc ctcgattatt tgatcacatc ctatctatac 3720
tctgtgtacc cagatctgaa gcctgggcag ttgactgatc tgagatcagt ttctgtaaac 3780
aacaacacct tcgcagttgt tgcagtacat caaagcttcc acagccgtat actctgtgat 3840
tctagtgacc tccgtgagtc aattactaga tatgtcaatt tcattggaag accagattct 3900
atgaaaaggc tggctgaaga gccatcttgt ccaaaggccc ttggcgacct ggtggagtct 3960
tgtatgggtg caatcctgct tgacacaggg tttgacttga accgtgcttg gcatataatg 4020
ctctccttct taaagcccgt catgagcttt accaggttgc agcataatcc aaaaagagaa 4080
ctccatgaac tttgccagtt tcatggctgg catctaaagt tcctggtttc aaaaaaagat 4140
agcaaatatc tagttgaggc caatgtgagt gggaagaatg tttctgaagc ggcttctgct 4200
cccaatatca ataaaaaagc tgccaaaaga atggctgccc agcaagtact ttcaagcttg 4260
acggctcaag gctataggcg caagtctaaa tcactggagc aagtggtaaa aacagctaaa 4320
aagatggaag ctaaactgat aggatatgat gaaacaccct gtgttcttac tgctaggtgc 4380
aatgacgtgg agaagaacga agcatctgaa agtgatcgtg acttgatagt attccctatt 4440
agtgaagaac ttgcaagaaa ttgcaatttc aagttaaagc ctgcgagaaa gttggcccca 4500
gaggcagctg tacaatgcaa ttctgagcag accatcatgc ctaatggttc taattcagat 4560
tcaaaagcta caggtggtgc aataaatgga tcggcaaagt caattttgca tgaagtttgt 4620
gctgccaact gctggaaacc tcctagattt gaatgttgca aggagacagg gccaagccac 4680
ttgaaagacc tatggcacct acctnctcgg gcgaaaaaga aagatgcagc tgaggatgca 4740
gcggaagggg cactttggtt cttgaagcag gaaggatata tgttcaataa ctga 4794
<210> 78
<211> 3426
<212> DNA
<213> Artificial sequence
<220>
<223> RDR1A Cdna
<400> 78
atgggaaaga caattcaggt ttttggattc ccttatcttc tgtctgccga agcggtcaag 60
aaattcttag agaatcatac aggaaatgga actgtctatg ctgtggaggt taaacagtcc 120
aaaggtggac gtagagcatt cgccatagtt caatttgcca acaacaaaag cgcagaattt 180
atcatcgatt tggctagtaa gcggttgtat tatggaactt cttatttgaa ggcttgggaa 240
atgaaaactg atattgtcca accgcggaca tatgtgcaac acatggatgg cgtaactctg 300
aattttggat gtctgatatc agacaagaag tttgcagtgt tgggaagtaa aggtgtttca 360
gttaaatttg gcattggatt gaagaaaatt tacttctttt tatctcatgc ttcagctgat 420
tataaacttc agctttcata tgaaaatata tggcaagttg tccttcatcg tccatatggt 480
caaaatgctc agtttctcct cctacagtta tttggtgctc ctcggatcta taagagactt 540
gaaggctcct gttatagctt ctttaaggaa actcctgatg atcagtgggt aaggacaaca 600
gatttcacta catcttggat agggctatct tctagcttat gtttggagtt tcgtaatggt 660
ggtcgacttc caaatttcag cgaaagtttt ttttactata aagaaagtgt gagccaagtt 720
attttacaga ctggttacac cttttcattc tctcaaaatt tggctctggt tcccattgtc 780
caccttcctg aaggtgttga gttgccctac aagatattgt ttaaaattag ttccttgata 840
caacatggat gctttcctgg actagcatta aattttaact ttttccaatt agttgaccct 900
cgaaggagaa atattgcatg cattgaacac gccttggaga aactgtacta tttaaaggag 960
tgttgttatg atccagtgag gtggctaact gagcagtatg atgagtacct caaccgcaga 1020
caacttccaa aatctccgtc catcacttta gatgatggat tggtgtatgt aagaagggtc 1080
ctagtaacac catgcaaagt ttatttttgt ggtccagagg ttaatgtatc gaatcgggtt 1140
ctgcgcaatt attctgaaga catagataac tttcttcgag tttcttttgt tgatgaggag 1200
tgggagaaaa tacattctac agatttatta acaagagcta gtagtggaaa tggtatcagg 1260
acagacatct atgagaggat cctatcaact cttcggaatg gctttataat tggtgataaa 1320
agatttgaat ttcttgcatt ttcatcgagc cagttgcggg ataattcagt gtggatgttt 1380
gcatcaagac ctggccttac tgcaaatgat ataagaacat ggatgggtga ttttcagcaa 1440
atcaggaatg tcgcaaaata tgctgccaga cttggccaat cttttggttc ctccagagaa 1500
actttgagtg tcggtaggca tgaggctgaa gttattcctg atgtagtttg ttcgcttcat 1560
ggaaccaact acatcttttc tgatggaatt ggaaaaatat ctgctgactt tgctcgtaga 1620
gttgccataa aatgtggcct tcagtatact ccatcttctt ttcagattcg ttatggtgga 1680
tataaaggtg ttgtggctgt tgatccatat tcatcaatga agttatcttt gagaaagagc 1740
atgttgaaat atgaatcaaa caacataaag ttagatgtcc tgggatggag caaatatcag 1800
ccttgttatc ttaatcgtca actggttact ctcttgtcta cacttggggt gaaagatgat 1860
gttttcgaac agaagcaaaa tgaagcggta gagcagcttg atgctatctt gcatgattct 1920
ttgaaggcac aggaagcttt agaattgatg tctcctggag agaacactaa tattctcaag 1980
gagatgctaa attgtggtta tatgcctgat gctgagccgt ttctttcaat gatgctgcaa 2040
actttccggg cttcaaagtt gctcgatttg cggactcgat caagaatatt tattccaaat 2100
ggaagagcga tgatgggatg cttggatgaa tccagaaccc tggaatatgg tcaggtgttt 2160
gttcagttta ctggtactgg acgtagacag ttttatgagg aatcacatcc ttttaatgac 2220
agtggatcca ccaactgtaa tttcattctc gagggaaatg tggtcgttgc aaaaaatcca 2280
tgcttgcatc ctggtgatat tcgtgtttta agggctgttg atgttccagc tttgcaccac 2340
atggtagatt gtgttgtatt tccccagaaa ggaaaaagct tccatcctta taagaactgt 2400
ttttatcttt tttttcatgg cattgtttct cagtgtttaa actttgatga cagacctcat 2460
ccaaatgaat gttctggaag tgatttggat ggggatatct attttgtttg ttgggatcca 2520
gacctgattc cgccaaggca agtccagccg atggattata ctccagcacc cagcacacag 2580
ttggatcatg atgtcacaat tgaggaagtt caagagtact tcaccaacta tattgtgaat 2640
gacagtttgg gaatcatagc gaatgcgcat gttgtatttg cagacagaga acctgatatg 2700
gccatgagtg atccgtgcaa acaactcgct cagctctttt caattgcagt tgactttcca 2760
aagactggtg ttcctgctga aataccatct cagttgcgcc ctaaagaata ccccgacttc 2820
atggaaaagc cagacaagcc aacctatcac tcggaaaaag ttattggaaa acttttccag 2880
aaagtgaagg acaaaacacc tcaggcttgc tctatcgcga ccttcacaat ggatgttgcc 2940
aggaaatcat atgatggtga tatgatagtc aatggattcg aagattacat tgacgaagct 3000
ttttactaca aaagtgaata cgacaacaag cttggtaatt taatggacta ctacggcgta 3060
aaaactgagg ctgaaatact tagtggtggc atcatgaaag catcaaaaac ttttgaccgc 3120
agaaaagatg cagaggccat tggtattgct gtgaggtctt tgaggaaaga agcaaggacc 3180
tggttcaaga agcgtagtga tatagatgac atgttagcaa aggcttcggc ttggtaccac 3240
gttacatatc atcatacata ttggggtctc tacaatgagg ggttgaaaag agatcatttc 3300
attagctttc cctggtgtgt ttatgaccag ctgatccaga ttaagaaggc gaaagcacgt 3360
aaaaagccgg ttctccattt atcttctctc gggaatcaac tgagtcgcaa attagtgttg 3420
atatga 3426
<210> 79
<211> 3351
<212> DNA
<213> Artificial sequence
<220>
<223> RDR1B Cdna
<220>
<221> misc_feature
<222> (2774)..(2774)
<223> n is a, c, g, or t
<400> 79
atgggaaaga caattcaggt ttttggattc ccttatcttc tgtctgcaga agcagtcaag 60
aaattcttag agaatcatac aggaaatgga actgtctatg ctttggaggt taaacagtcc 120
aaaggaggac gtagagcatt cgcaaaagtt caatttgcca acaacaaaag cgcggaattt 180
atcatcgatt tggctagtaa ggggttgtat tatggacctt cttatttgaa ggcttgggaa 240
atgaaaactg atattgtcca accgcggaca tatgtggaac acatggatgg cgtaactctg 300
aattttggat gtcagatatc agacaagaag tttgcagtgt tgggaagtaa agatgtttca 360
attaaatttg gcattggatt gaagaaaatt tacttctttt tatctcatgc ttcagctgat 420
tataaactcc agctttcata tgaaaatata tggcaagttg tccttcatcg tccatatggt 480
caaaatgctc agtttctcct cctacagtta tttggtgctc ctcggatcta taagagactt 540
gaagattcct gttatagctt ctttaaggaa actcctgatg atcagtgggt aaggacaaca 600
gatttcactc catcttggat agggctatct tctagcttat gtttggagtt tcgtaatggt 660
gttcaacttc caaatttcag cgaaagtttt ttttactata aagaaagtat gaaccaattt 720
attttacaga ctggtttcac cttttcattc tctcaaaaat tggctctggt tcccattgtc 780
caccttcctg aaggaattga gttgccctac aagatattgt tcaaaattag ttccttgata 840
caacatggat gctttcctgg gctagcttta aattttaact ttttccaatt agttgaccct 900
cgaaggagaa atattgcatg cattgaacac gccttggaga aactgtacta tttaaaggag 960
tgttgttatg atccagtgag gtggctaact gagcagtatg atgagtacct caagggcaga 1020
caacttccaa aatctccgtc catcacttta gatgatggat tggtgtatgt aagaagggtc 1080
gtagtaacac catgcaaagt ttatttttgt ggtccagagg taaacgtatc caatcgggtt 1140
ctgcgcaatt attctgaaga cataaataac tttcttcgag tttcttttgt tgatgaggag 1200
tgggagaaaa tacattctac agatttatta ccaagagcta gtactggaaa tggtaccagg 1260
acagacatct atgagaggat cctatcaact cttcggaatg gctttataat tggtgataaa 1320
agatttgaat ttcttgcatt ttcatcgagc cagttgcggg ataattcagt gtggatgttt 1380
gcatcaagac ctggccttac tgcaaatgat ataagaacat ggatgggtga ttttcggcaa 1440
atcaggaatg tcgcaaaata tgctgccaga cttggccaat cttttggttc ctccagagaa 1500
actttgagtg ttggtaggca tgaggttgaa gttattcctg atgtagtttg ttcgcttcat 1560
ggaaccaact acatcttttc agatggaatt ggaaaaatat ctgctgactt tgctcataga 1620
gttgccataa aatgtggcct tcaatatact ccatcttctt ttcagattcg ttatggtgga 1680
tataaaggtg ttgtggctgt tgatccatat tcatcaatga agttatcttt gagaaagagc 1740
atgttgaaat atgaatcaaa caacataaag ttagatgtcc tgggatggag caaatatcag 1800
ccttgttatc ttaatcgtca actggttact ctcttgtcta ctcttggggt gatagatgat 1860
gttttagagc agaagcaaaa tgaagcagta gatcagcttg atgctatttt gcatgattct 1920
ttgaaggcac aggaagcttt agaattgatg tctcctggag agaatactaa tattctcaag 1980
gagatgctaa attgtggtta tatgcctgat gctgagccgt ttctttcaat gatgctgcaa 2040
actttccggg cttcgaagtt gctcgatttg cggactagaa caagaatatt tattccaaat 2100
ggtagaacga tgatgggatg cttggatgaa tccagaaccc tggaatatgg tcaggtgttt 2160
gttcagtttt ctggtgctgg acgtagacag ttttttgagg aatcgcatcc ttttaatgac 2220
agtggatccg ccaactgtga tttcattctc aagggaaacg tggtcgttgc aaaaaatcca 2280
tgcttgcatc ctggtgatat tcgtgtttta agggctgttg atgttccagc tttgcaccac 2340
atggttgatt gtgttgtatt tccccagaaa ggaaaaagac ctcatccaaa tgaatgttct 2400
ggaagtgatt tggatgggga tatctacttt gtttgttggg atccagactt gattccgcca 2460
aggcaagtcc agccgatgga ttatactcca gcacccacca cacagttgga tcatgatgtc 2520
acaattgagg aagttgaaga gtacttcacc aactatatca ttaatgacag tttgggaatc 2580
atagcaaatg cgcacgttgt atttgcagac agagaacctg atatggccat gagcgatccg 2640
tgcaaacaac ttgctcagct cttttcaatt gcagttgact ttccaaagac tggcgttcca 2700
gctgaaatac catctcagtt gcgccctaaa gaatacccag acttcatgga aaagccagac 2760
aagccaacct atcnctcgga aaaagttatt ggaaagcttt tccagaaagt gaagaacaaa 2820
acaccccagg ctagctccat cgcgaccttc acaagggatg ttgccaggaa atcatatgat 2880
agtgatatga tagtcgatgg attcgaagat tacattgacg aagcttttta ctacaaaagt 2940
gaatacgaca acaagcttgg taatttaatg gactactacg gcataaaaac tgaggctgaa 3000
atacttagtg gtggcatcat gaaagcatca aaaacttttg accgcagaaa agatgcagag 3060
gccattggtg ttgctgtgag gtgtttgagg aaggaggcaa gggcctggtt caagaggcgt 3120
agtgatattg atgacatgtt agcaaaggct tcggcttggt accatgttac atatcatcat 3180
acatattggg gtctctacaa tgaggggttg aaaagagatc atttcattag ctttccctgg 3240
tgtgtttatg accagctgat ccagattaag aaggcaaaag ctcgtaaaag gccggttccc 3300
cacttgtctt cactcgggag tcaactgagt cgcaaattag tgatatggta g 3351
<210> 80
<211> 3363
<212> DNA
<213> Artificial sequence
<220>
<223> RDR1B Cdna
<400> 80
atgggtgtag agaagagaat tacagcaact gtgagggtct caaacattcc tcaaacagcc 60
atagccaaac aactcttcga cttcttcgag tcttcaattg ggaaaggatc agtctttgct 120
tgcgatattt tctcagagca caagaattgg aaatcaagag gtcatggtcg agtccaattc 180
gaaacagcgc aatccaagtt acaatcttta tcactatctg aacaagggaa gctcgtcttt 240
aaagggcacc aactcattct aacctcgtct tttgatgata ttattgccag gccaattgag 300
cccaactaca ggtttcaaaa gggaatcttg catactgggg tactgttaaa gaatgattac 360
atggaagttt tggagacttg ggaaaatgtg aagacgttga tcatgcctga aagaaagagt 420
cttgagttct gggttagtca tgcaaagggg gaatgttata ggttggaggt ccagtttggc 480
gacattatag agacttgtgg gtgctctttg gaagatgaaa aacctgcact ccttttaaag 540
ctaaaacatg caccaaagct ataccaaaga gtttctggac ccggtgttgc ttcaaagttc 600
agttctgacc ggtaccatgt ttgcaaggag gattgtgagt tcctttgggt tcgcacaact 660
gatttttctg ccatgaagtc tatcggatgt tcatcctctc tttgttggga aatcgaagac 720
ggattgttaa gttcagattt gctttctagt ttgccatatt gtaacaacga tgtgatggat 780
cttgttctgg atgaagtagg agatatttat tctgcttctg aattagttcc tcttgcaagt 840
ttcccatcag atctgaagct accatatgag atccttttcc agcttaactc tctcgtacac 900
acacataaaa ttagtcttgg tgctgttaaa actgatctta ttgaagttct tagcaaatta 960
gaattggaca ctgcaatgat gatccttcag aaaatgcata agttgcagtc aagctgtttc 1020
gagcctgtgc cattcatcaa gacacgcctg catgtattgg gtaaaaacag taagaaccaa 1080
ccttcatcat cttacagcag gttagtgaat caaaacatga tgagtgttca cagagtcttg 1140
gtaacaccat caaaggttta ctgcctgggc ccagagcttg aaacctccaa ttacatcgtg 1200
aagaactttg catcacatgc ttctgatttc ttgagagtaa cttttgtaga agaggattgg 1260
agtaaacttt ctcctaatgc catttctata agtgttgaac aaggtatctt tgcaaagcct 1320
tacagaacta aaatctatca tcggattttg tctatccttc gagatggact tgttattgga 1380
actaaaagat ttcttttcct ggcgttctcg gctagtcagc tacgttcaaa ttcagtttgg 1440
atgtttgctt ccaatgagta tgtcaaggca gaagatatca gagagtggat gggctacttc 1500
aacaagattc gtagtgtctc gaaatgtgct gcaaggatgg gtcagttgtt tagcacctct 1560
tttcaaacaa tggaagtcca atcgccgcat gttgagattc ttccagatat tgaagtaacc 1620
tctgatggcg ttagttattg cttctcagat ggcattggaa agatttctca agcttttgcc 1680
agtcaagttg ctcagaaatg tggattgagt tataccccat cagcatttca aatacgatat 1740
ggtggttata aaggcgtgat agctgttgac cgcaattcct atcgaaagct atctctacgt 1800
ggcagtatgc tcaaatttga atctaagaac aagatgctta atattaccaa gtggagtgat 1860
gccatgcctt gctatctgaa ccgggagatt gttatcctct tagctacgtt gggagtggag 1920
gataaagtat tagaagacct gctagataat catctccatc ttctgggcaa gatgttgacc 1980
actaatgagg cggccttaga cgttttggag agcataggtg ggggtgacgt aaaaagaatc 2040
ttaatgagga tgttgcacca aggatatgcg cccaatttgg agccttatct ctcaatgatg 2100
cttcaatccc attttgagaa tcagctttca gacctaagaa gtaggtgtcg tatattcata 2160
cccaaaggtc gagttctagt aggatgccta gatgaaacag gtatattgaa ttatggccag 2220
gtttatgcac gaatcaccat gactaaggcc gagctacaaa gtggtcagca aaatttcttc 2280
cagaaggtgg atgaaacaac tgcagtagta agaggcaagg ttgtggtaac aaaaaatcct 2340
tgtcttcatc ctggagatgt aagagtactt gaagctgtgt atgaggtggc attagaggaa 2400
aaggcctggg tggattgcat tatttttcct cagaaaggtg aaaggcctca tccaaatgaa 2460
tgctccggtg gtgatcttga tggagatctt tatttcataa gttgggatga aaacctcatt 2520
cctcgtcaaa ctgtgacacc catggactac actgggcgaa aacctcgtat aatggatcac 2580
gaagtcactc tagaggaaat tcagagattc tttgttgatt acatgattag cgacactctt 2640
ggtgcgatct ctactgcaca tttggttcat gcagatcgtg aaccagataa agctctgaat 2700
ccgaaatgcc tccagttagc gacccttcac tctatggctg tggacttcgc aaaaactgga 2760
gctgcagctg agatgccaag gtttctaaaa ccaagagagt ttcctgattt cttggagagg 2820
tgggacaaac caatgtatat ttctgaaggg gtactaggga agctttatcg tgctatagtc 2880
aagtcttctg ttcgcggtaa ctcagatgac cttggctctg tcagagctat ccaggatgct 2940
tatgatcatg accttttgtt cgaaggttac gaggcattca tcgtaacagc taaaaatcac 3000
aaagaaatgt acttggatag aatgaacagc ttactcaact actatggagc agagaaagag 3060
gttgagatac tgacgggcaa tttgcgccag aaatctgtgt atttgcagcg ggacaacaga 3120
aggtattttg aactaaaaga tcgaatcttg gtttctgcca aaagcctaca gaaggaggtg 3180
aaagggtggt tcactggttg ctgcaaggag gatgagaaga agaaactggc atcagcatgg 3240
tatcaagtta cttatcatcc tagttactgc caaggaagtg ctaattgcct gggatttccc 3300
tgggtggtag gtgacgtttt gctggatata aagttgcata ataccagaaa aatcacctcc 3360
tag 3363
<210> 81
<211> 3363
<212> DNA
<213> Artificial sequence
<220>
<223> RDR2B Cdna
<400> 81
atgggtgtag agaagagagt tacagcaact gtgagggtct caaacattcc tcaaacagcc 60
atagccaaac aactcttcga cttcttcgag tcttcaatta ggaaaggatc agtctttgcc 120
tgcgatattt tctcagagca caagaattgg aaatcaagag gccatggtcg agtccaattc 180
gaaacatcgc aatccaagtt acaagcttta tcactatctg aacaagggaa gctcatcttt 240
aaagggcacc aacttattct aacctcgtct tttgatgata ttattgtcag gcccattgag 300
cccaactaca ggtttcaaaa gggaatcttg catactgggg tactgttaaa gaatgattac 360
atggaagttt tggagacttg ggaaaatgtg aagacgttga tcatgcctga aaggaagagc 420
cttgagttct gggttagtta tgcaaagggg gagtgttata ggttggaggt ccagtttggt 480
gacattatag agacttgtgg gtgctctttg gaagatgaaa aacctgcact ccttttaaag 540
ctaaaacatg caccaaagct ataccaaaga gtttctggac ctggtgttgc ttcaaagttc 600
agttctgacc ggtaccatgt ttgcaaggag gattgtgagt tcctttgggt tcgcacaact 660
gatttttccg ccatgaagtc tattggatgc tcatcctctc tttgttggga aatcgaagac 720
ggattgttaa attcagattt gctttctagt ttgccatatt gtaacaatga tgtgatggat 780
cttgttctgg atgaagtagg agatatttat tctgcttctg aattagttcc tcttgcaagt 840
ttcccatcag atctgaagct accatatgag atccttttcc agcttaactc tctcgtacac 900
tcacataaaa ttagtcttgg tgctgttaaa actgatctta ttgaagttct tagcaagtta 960
gaattggaca ctgcaatgat gatccttcag aaaatgcata agttgcagtc aacctgtttc 1020
gagcccgtgc cattcatcaa gacacgcttg catgtattgg gtaaaaccag taagaaccaa 1080
ccttcatcat cttacagcag gttagtgaat caaaacatga tgagtgttca cagagtcttg 1140
gtaacaccat caaaggttta ctgcctgggc ccagagcttg aaacctccaa ttacatcgtg 1200
aagaactttg catcacatgc ttctgatttc ttgagagtaa cttttgtaga agaggattgg 1260
agtaaacttt ctcctaatgc catttctatg agtgttgaac aaggtatctt tgcaaagcct 1320
tacagaacta aaatctatca tcggattttg tctatccttc gagatggact tgatattgga 1380
actaaaaaat ttcttttcct ggcgttctcg gctagtcagc tacgttcaaa ttcggtttgg 1440
atgtttgctt ccaatgagta tgtcaaggca gaagatatca gagagtggat gggctgcttc 1500
aacaagattc gtagtgtctc gaaatgtgct gcaaggatgg gtcagttgtt tagcacctct 1560
tttcaaacca tggaggtcca atcgccgcat gttgagattc ttccagatat tgaagtaacc 1620
tctgatggcg ttagttattg cttctcagat ggcattggaa agatttctca agcttttgcc 1680
agtcaagtag ctcagaaatg tggattgagt tataccccat cagcatttca aatacgatat 1740
ggtggttata aaggcgtgat agctgttgac cgcaattcct ttcgaaagct atctctacgg 1800
ggcagtatgc tcaaatttga atcaaagaac aggatgctta atattaccaa gtggagtgat 1860
gccatgcctt gctatctgaa ccgggagatt gttatcctct tatctacgtt gggagtggag 1920
gataaagtat tagaagacct gctagataat catctccatc ttctgggcaa gatgttgacc 1980
actaatgagg cagccttaga cgttttggag agcataggtg ggggtgacgt aaaaagaatc 2040
ttaatgagga tgttgcacca aggatatgcg cccaatttgg agccttatct ctcgatgatg 2100
cttcaatccc attttgagaa tcagctctca gacctaagaa gtaggtgtcg tatattcata 2160
cccaaaggtc gagttctagt aggatgccta gatgaaacag gtatattgaa ttatggccag 2220
gtttatgcac gaatcaccat gactaaggcc gagctacaaa gtggtcagca aaatttcttc 2280
cagcaggtgg atgaaacaac tgcagtagta agaggcaagg ttgtggtaac aaaaaaccct 2340
tgtcttcatc ctggagatgt aagagtactt gaagctgtgt atgaggtggc attggaggaa 2400
aaggcctggg tggattgcat tatttttcct cagaaaggtg aaaggcctca tccaaatgaa 2460
tgctccggtg gtgatcttga tggagatctt tatttcataa gctgggctga aaacctcatt 2520
cctcgtcaaa ctgtgacacc catggactac actgggcgaa gacctcgcat aatggatcac 2580
gaagtcactc tagaggaaat tcagagattc tttgttgatt acatgattag cgacactctt 2640
ggtgctatct ctactgcaca tttggttcat gcagatcgtg aaccagataa agctctgaat 2700
ccgaaatgcc tccagttagc aacccttcac tctatggctg tggacttcgc aaaaactgga 2760
gctgcagctg agatgcccag gtttctaaaa ccaagagagt ttcctgattt cttggagagg 2820
tgggacaaac ccatgtatat atctgaaggt gtactaggga agctttatcg tgctatagtc 2880
aagtcttctg ttcgcggtaa ctcagatgac cttggctctg tgagagctat ccaagatgct 2940
tatgatcatg accttttgtt cgaaggttac gaggcattca tcgaaacagc taaaaatcac 3000
aaagaaatgt acttggatag aatgaacagc ttactcaact actatggagc agaaaaagag 3060
gttgagatac tgacgggcaa tttgcgccag aagtctgtgt atttgcagcg ggacaacagg 3120
aggtattttg aactaaaaga tcgaatcttg gtttctgcca aaagcctaca gaaggaggtc 3180
aaagggtggt tcactggtta ctgcaaggag gatgagcata agaaattggc atcggcgtgg 3240
tatcatgtta cttatcatcc ttcttactgc gaaggaagtg ctaattgcct gggctttccc 3300
tgggtggtag gtgacatttt gctggatata aagttgcata ataccagaaa aatcacctcc 3360
tag 3363
<210> 82
<211> 3594
<212> DNA
<213> Artificial sequence
<220>
<223> RDR6A Cdna
<400> 82
atgggatcag agggctctga aaaggatctc gtagtgactc aaattagtgt tggtgggttt 60
gacaatgatg tcaatgcgaa aatgctttca gaatatctgg aagaacaagt tggacaagta 120
tggagatgta gattaaagat ttcagccacc cctcctgact cttacccaac ttatgacatt 180
gatgcagaga gggtgcatag aatgaaagat tacgaaaaag tggtacctca tgcattcgtt 240
cattttgcat cttcagagtc cgcaaagcat gctctggctg ctgctggggg taatgagctc 300
atattaggaa agaagccttt gattgttagt ttgggacctg agaatcccta tcgtctgaat 360
cagcggagaa gaactaccat gccctttaga ttttcagatg ttagtgtaga gttgggagta 420
ctggttagta aagatgactt tgtggttggt tggaggggac ctcgcactgg tgttgacttt 480
tttgtggacc cattcaacgg ggcatgcaga atacttttca caaaggatac tgctttctct 540
ttcaggggtg aagccagaca tgccattata aaatgcaatt tcaagattga gtttatggta 600
agggaaatca atgagataaa gaaatgtaaa gactttacgt ctttggtaat actgttgcag 660
ttggcttcat ctccattggt tttctataga actgctgatg atgatattga agaatcagtt 720
gcatttgact tgttagacga tgatgatcaa tggatccgta ccacagacat tacaggtagt 780
ggagccattg gtaggtgtaa tacctaccgt atttcaattc gacctcgcaa tggtcctagc 840
tttgagaagg ccatggcata tttcagtttt cgtagggttc ccatggtaga aatgtgtaac 900
cggaagatgc tccgggtgag ggacgagcct gattttgggg tgtccatgtc agatcctttc 960
ttctgcttcc aaaatgaagg tataagcttt aaggtcatgt ttctggtgaa tgcggttttg 1020
cacaaaggca tagttaatca gcatcaaatg actaatgaat tcttttactt acttagaagt 1080
cgtcaggagg aggttaattt agctgcactg aagcacatgt tttcttacaa atggcctgtc 1140
aatgatgcta ttcagaagtt agtaggcatc cagaaatggc tgttgaaaaa ccctaaactt 1200
ctcgagagaa ctggagagtt ggatgatatt gtagaggtta ggagattggt tatcacccca 1260
accaaagcat actgtcttcc accgactgtg gagctttcca acagagtcct caggaattat 1320
aaacatgttg cagatcgatt tttgcgagtt acattcatgg acgagggcat gcggaacttg 1380
aataggaatg tgctgacata ctatgctgct accattgtga gggaaatcac atcaaattcg 1440
aatccccaga gaactgcaat cttccaaagg gtgaaaagta ttctgagtaa aggatttcat 1500
ttgtgtggtc gaaagtactc ctttttggca ttctcagcta accagctgag ggatcgttct 1560
gcctggtttt ttgcagaaga ccctaaaatt agggtacccg gcatcataag ctggatgggg 1620
aggttcagta acaggaatgt cgccaaatgt gcagctagga tgggacagtg cttttcatca 1680
acttatgcaa cagtggaagt cccttcaagg gaggttaact cagagcttcc agatattgaa 1740
agaaatgggt atgttttctc tgatggaatc ggcatgatat cagcagatct agctatagaa 1800
gttgcagaga agctgcattt aagtgtcaac cctccttctg cttatcagat aaggtatgct 1860
ggttgtaaag gtgttgttgc ttgttggccg acaaagaatg atggcatccg cctttctctg 1920
aggccaagta tgaagaaatt cgactcaaat cacactatcc ttgaaatatg ctcttggacg 1980
agatttcaac ctggtttcct gaaccggcaa atagtaaccc tgctctcttc cttggacgtt 2040
aaagatggaa tattctggga aatgcaaaaa gaaatgatat cagggttgga taaaatgctc 2100
gtggattcgg acgtggcttt tgatgtcatc acagcttcat gtgctgaggc aggaaatact 2160
gcagctctaa tgttgagtgc aggttttaaa cctcaaagtg agcctcattt aagagggatg 2220
ctctctagca taagagcttc tcagcttggg gacctcagga ataaggcaag gatatttgtt 2280
ccttcgggaa ggtggttgat gggctgtttg gatgaattag gtgagcttga gcaaggccaa 2340
tgctttattc aagtgtcaag cccttctttg gagaattgtt ttattaagca tggtccgaaa 2400
ttttctgata taaagcaaaa tcttcaagta gtaaagggcc ttgttgtaat tgcaaagaac 2460
ccgtgtcttc atcctgggga tgtgaggatt ctggaggctg tagatgttcc tggtttacac 2520
catctctatg attgtctggt ctttcctcag aagggggata ggccacattc aaatgaagca 2580
tcaggaagtg acctggatgg tgacctctac tttgtgactt gggatgaaaa tctcatccca 2640
cccagtaaga aaagctggat cccgatgaac tatgaacctg cggaagtcaa acagttgggt 2700
cgtcaagtta atcatatgga cataatagat tttttttcaa aaaacatggt ccaagagagt 2760
ctaggagaaa tctgcaacgc acatgtggtt catgctgacc tcagtgaatt tggagctttg 2820
gatgagaagt gcctaaaatt ggcagagctt gctgctctag ccgttgactt ccccaaaact 2880
ggaaaacttg tgaccatgcc gtttgacctc aaaccaaaaa tgtatcccga cttcatgggg 2940
aaagaggaat tccaatcata caagtcaaag aaaattttgg gcaaattgta taggcaagtg 3000
aaagatgtat gtgatacaga gggtgaagta tctgctggac ttgagcttgt cccaaacgac 3060
atcccatatg actctagtct tgagatccca ggatccacag ctttcataga cgatgcatgg 3120
aacagcaaat gttcttatga tggtcagttg catggacttt tagggcaata caaagttaac 3180
agggaagaag aggtggttac tggacatata tggtccatgc cgaagtacag tgctaagaag 3240
caaggggaat taaaagagag gctgaagcac gcatataata cgctgaggaa ggagttcagg 3300
aatgtcttcg agcgtatgga tcctgatttt gatcttcttc ccgatgatga gaagaatgat 3360
atgtatgaaa gaaaggcatc tgcatggtat caggtcacct acaatcctca ttgggttgct 3420
agatcactgg agttgcaatt gccagatgct atctcaagta ctgtaatgct aagttttgca 3480
tggattgcag cagattacct tgctcgaatt aaaattaggc acaggggatt gcagtattcc 3540
gactctacca agccaatcaa ttcccttgga aggtatcttg ttgacaaaat atga 3594
<210> 83
<211> 876
<212> DNA
<213> Artificial sequence
<220>
<223> RDR6B Cdna
<400> 83
gacataatag attttttttc aaaaaacatg gtccaagaga gtctaggaga aatctgcaac 60
gcacatgtgg ttcatgctga cctcagtgaa tttggagctt tggatgagaa gtgcctaaaa 120
ttggcagagc ttgctgctct agccgttgat ttccccaaaa ctggaaaact tgtaaccatg 180
ccttttgacc tcaaaccaaa aatgtatccc gacttcatgg ggaaagagga attccaatca 240
tacaagtcaa agaaaatttt gggcaaattg tataggcaag tgaaagatgt atgtgatgca 300
gagggtgaag tatctgctgg acttgaggtt gtcccaaaag acatcccata tgacactact 360
cttgagatcc taggatccac aactttcata gacgatgcat ggaacagcaa atgttcttat 420
gatggtcagt tgaatggact tttaggacaa tacaaagtga acagggaaga agaggtggtt 480
actggatata tatggtccat gccgaagtac agtgctaaga agcaaggaga attaaaagag 540
aggctgaagc acgcatataa tatgctgagg aaggagttca ggaatgtctt cgagcgtatg 600
gagcctgatt ttgatcttct tcctgatgat gagaagaatg atatgtatga aagaaaggca 660
tctgcatggt atcaggtcac ctaccatcct cattgggttg ctagatcact ggagttgcaa 720
ttggcagatg ctgtctcaaa tactgtaatg ttaagttttg catggattgc agcagattac 780
cttgctcgaa ttaaaattag gcacagggga ttgcagtatt ccgactctac caagccaatc 840
aattcccttg gaaggtatct tgttgacaaa atatga 876
<210> 84
<211> 876
<212> DNA
<213> Artificial sequence
<220>
<223> RDR6C Cdna
<400> 84
gacataatag attttttttc aaaaaacatg gtccaagaga gtctaggaga aatctgcaac 60
gcacatgtgg ttcatgctga cctcagtgaa tttggagctt tggatgagaa gtgcctaaaa 120
ttggcagagc ttgctgctct agccgttgat ttccccaaaa ctggaaaact tgtaaccatg 180
ccttttgacc tcaaaccaaa aatgtatccc gacttcatgg ggaaagagga attccaatca 240
tacaagtcaa agaaaatttt gggcaaattg tataggcaag tgaaagatgt atgtgatgca 300
gagggtgaag tatctgctgg acttgaggtt gtcccaaaag acatcccata tgacactact 360
cttgagatcc taggatccac aactttcata gacgatgcat ggaacagcaa atgttcttat 420
gatggtcagt tgaatggact tttaggacaa tacaaagtga acagggaaga agaggtggtt 480
actggatata tatggtccat gccgaagtac aatgctaaga agcaaggaga attaaaagag 540
aggctgaagc acgcatataa tacgctgagg aaggagttca ggaatgtctt cgagcgtatg 600
gagcctgatt ttgatcttct tcctgatgat gagaagaatg atatgtatga aagaaaggca 660
tctgcatggt atcaggtcac ctaccatcct cattgggttg ctagatcact ggagttgcaa 720
ttggcagatg ctgtctcaaa tactgtaatg ttaagttttg catggattgc agcagattac 780
cttgctcgaa ttaaaattag gcacaggaga ttgcagtatt ccgactctac caagccaatc 840
aattcccttg gaaggtatct tgttgacaaa atatga 876
<210> 85
<211> 5
<212> DNA
<213> Artificial sequence
<220>
<223> PAM sequence for CRISPR
<220>
<221> misc_feature
<222> (1)..(2)
<223> n is a, c, g, or t
<400> 85
nngrr 5
<210> 86
<211> 8
<212> DNA
<213> Artificial sequence
<220>
<223> PAM sequence for CRISPR
<220>
<221> misc_feature
<222> (1)..(4)
<223> n is a, c, g, or t
<400> 86
nnnngatt 8
<210> 87
<211> 8
<212> DNA
<213> Artificial sequence
<220>
<223> PAM sequence for CRISPR
<220>
<221> misc_feature
<222> (1)..(4)
<223> n is a, c, g, or t
<220>
<221> misc_feature
<222> (6)..(8)
<223> n is a, c, g, or t
<400> 87
nnnngnnn 8
<210> 88
<211> 4315
<212> DNA
<213> Artificial sequence
<220>
<223> Ntab-XylT-A exemplary contig Ntab-BX_AWOK-SS596
<400> 88
atgaacaaga aaaagctgaa aattcttgtt tctctcttcg ctctcaactc aatcactctc 60
tatctctact tctcttccca ccctgatcac ttccgccaca aatcccgcca aaaccacttt 120
tccttgtcgg aaaaccgcca tcataatttc cactcttcaa tcacttctca atattccaag 180
ccttggccta ttttgccctc ctacctccct tggtctcaaa accctaatgt tgtttggaga 240
tcgtgcgagg gttacttcgg taatgggttt actctcaaag ttgaccttct caaaacttcg 300
ccggagtttc accggaaatt cggcgaaaac accgtctccg gcgacggcgg atggtttagg 360
tgttttttca gtgagacttt gcagagttcg atctgcgagg gaggcgcaat acgaatgaat 420
ccggacgaga ttttgatgtc tcgtggaggt gagaaattgg agtcggttat tggtaggagt 480
gaagatgatg agctgcccgt gttcaaaaat ggagcttttc agattaaagt tactgataaa 540
ctgaaaattg ggaaaaaatt agtggatgaa aaattcttga ataaatactt accggaaggt 600
gcaatttcaa ggcacactat gcgtgagtta attgactcta ttcagttggt tggcgccgat 660
gattttcact gttctgaggt tagattttga atttttgttt gctctttaaa ttaaaggttt 720
aaactttgtg aatgttggca gatatggaat acactaatgg attttgtttg atctgtttaa 780
tgaagattgt ctagaacctc aatgttataa atatggtttg gttgcttcat taattaaaga 840
gaattcctta atatcccgac tagatgccag ataacaccag ttagttgact tttggattat 900
tggttgcatt tcatttgatc agataaattg ttcattctta aatgtttcac taaagaatta 960
ctcaagattt cagagtttat atgtaggtgt atgtatttgg aattctggat ttggatctag 1020
tattgaatgg attactgaac ttgtactccc cagtcatctg gggaggagca atagatcaaa 1080
ttcaagggtt gaaaagtaat actgagtcag aaattaacca ctttaacttg gaaaacggta 1140
aatgtatgtg ttctaagatg gttattccta taacttttga tgtctaatat ggagaaagtg 1200
agttgattta tgctttttcc ttttcccttt attggtgttg gtttttaaat tctatcaatt 1260
cctttgtttg attgctactc aaattgaacc ttagacggag tagcaatagc aaaaagtgaa 1320
ggccattctt ttctcctttc atctctttat ttccgtttga catacagaat atggtagcat 1380
ctgtctgaag tggttaattt tattccttaa aatttgcata actaattcga gtaaatgcct 1440
tttgaagctt tagttgaata gttctacaac tggttgttgc attttgagga ctatcgactt 1500
gatttgacac ttgacattgt ctgatacatg gcttgtaagt tatgaaaact tttatctagg 1560
aagaaatccc aaccagagat agggagctgt cacttggtta tgagctactg gctcaaagtt 1620
caagtttgac cagttaattt tagatcttca ccaggataac atttagagtc taatcaaatt 1680
ctgaagcagt attgtgcact aataagagga acacatgaag gatgtagcac tactaggtta 1740
tgttacctta tttactaatg attgacaacc agcttaaatg atgacaaata gtcttatatt 1800
tgctttttca cattgctcat gacttgggat atttccgaat caacatattt tagttcttta 1860
tgtacttaac tacttatcaa aaaattatcc ctgctagatg ttagtgttca agcaaccatg 1920
ctagctttta aggaagctcc ttctttgatt catgccatct ttccgaaatc gatgccttac 1980
gttactgtca tttttctaat tttcatttca gtggattgag gagccgtcac ttttgattac 2040
acgatttgag tatgcaaacc ttttccacac agttaccgat tggtatagtg catacgtggc 2100
atccagggtt actggcttgc ccagtcggcc acatttggtt tttgtagatg gccattgtga 2160
ggtatgtttg aaagtattga taacgatggc atgcattgta ctgtgttacg gatgaaagaa 2220
atgaaaccag caattatttt ctagcaggca atgctcttga gatgcttgtg tcaaattggt 2280
cagacttaat cctgagtttc catttgtttc agctttctgt ttgactgact acaataattg 2340
tcccaattag gggtgtcaat ggatattcga aagccgacta aaccgaccga accgtaccgt 2400
accgattttt aggtttcttt ttaagaaacc gtaggttttt atataaatct ataaccgcac 2460
cgataattag ggtaggtttt ttattttata aaaataagcc gaaaaaatac cgaaccgtac 2520
cgaataaatt ttacatgtgg aaaatatatt tatttagtaa gtttaaaaat aataatgcat 2580
taaattttct ttgggccatg gaattatgaa aactattaca agccaacaag taattagact 2640
caaaatacta attcctaaaa cctattatgt tacttctact taaactaagt tatttcaagt 2700
atctttatta gcaagacaca aagtattcta gcgattatga gtagcaaact acaatgtatt 2760
gaatatgttt cctttcatgt aatttagatt tatctttttg aatatttaat cttctataga 2820
ctctattctt gagtcccagc ttggtatatc tttcaactcg tgtgatttat attttctttg 2880
cctttgtttg atttctttta cgttgttgta gaatagtcga tggatctata ctctagccat 2940
ctttcttttt ctttttttaa ttcatcacct tttaaacagt aaaaatgtct aaagaatttt 3000
tctaagtcct ataaaagaac gtatgttatt gcattctact tctactggtg aattttacat 3060
gatattaaaa aattaaccga accttaccgc taccgaagag aaaccgacat gattgggacg 3120
gtttcgaaaa gtctaatttt ggttatacat aatagaataa ccgaaaaatt ggtatggtac 3180
aaattttata aaataaccgg ccgaaccgaa ccattgacac ccctagtccc aatacctagt 3240
tgttgcagtt tgctcattct tacttctatt tacgtcactg tttctctgaa tggtcccttt 3300
gtggtgaaaa gagcttttgc tatgtagaaa aactagcaat gatttcatag ctgaaacaat 3360
ttatttttac cttacatcat gtcttataaa attgcttcta actgtatact ttaattcttg 3420
gagagatgct ttcatgtgaa gaaagttctt tcactccact actggaagct tgccgtatga 3480
attttacttg gccatattgt ggccgtgctt tgatttatct tcaaattcat tttcttcata 3540
tagttctttc gagtaattct tttttcctct tttctgtttg aaaaaaattc agacacaatt 3600
ggaggaaaca tggaaagcac ttttttcaag cctcacttat gctaagaact ttagtggccc 3660
agtttgtttc cgtcatgccg ccctctcgcc tttgggatat gaaactgccc tgtttaaggg 3720
actgtcagaa actatagatt gtaatggagc ttctgcccat gatttgtggc aaaatcctga 3780
tgataagaaa actgcacggt tgtccgagtt tggggagatg attagggcag cctttggatt 3840
tcctgtggat agacagaaca tcccaaggac agtcacaggc cctaatgtcc tctttgttag 3900
acgtgaggat tatttagctc acccacgtca tggtggaaag gtacagtcta ggcttagcaa 3960
tgaagagcaa gtatttgatt ccataaagag ctgggccttg aaccactcgg agtgcaaatt 4020
aaatgtaatt aacggattgt ttgcccacat gtccatgaaa gagcaagttc gagcaatcca 4080
agatgcatct gtcatagttg gtgctcatgg agcaggtcta actcacatag tttctgcagc 4140
accaaaagct gtaatactag aaattataag cagcgaatat aggcgccccc attttgctct 4200
gattgcacaa tggaaaggat tggagtacca tcccatatat ttggaggggt cttatgcgga 4260
tcctccagtt gtgatcgaca agctcagcag cattttgagg agtcttgggt gctaa 4315
<210> 89
<211> 3568
<212> DNA
<213> Artificial sequence
<220>
<223> Ntab-XylT-B exemplary contig Ntab-BX_AWOK-SS12784
<400> 89
atgaacaaga aaaagctgaa atttcttgtt tctctcttcg ctctcaactc aatcactctc 60
tatctctact tctcttccca ctctgatcac ttccgtcaca aatcccccca aaaccacttt 120
cctaataccc aaaaccacta ttccctgtcg gaaaaccacc atgataattt ccactcttct 180
gtcacttccc aatataccaa gccttggcca attttgccct cctacctccc ctggtctcag 240
aatcctaatg tttctttgag atcgtgcgag ggttacttcg gtaatgggtt tactctcaaa 300
gttgatcttc tcaaaacttc gccggagctt caccagaaat tcggcgaaaa caccgtatcc 360
ggcgacggcg gatggtttag gtgttttttc agtgagactt tgcagagttc gatttgcgag 420
ggaggtgcta tacgaatgaa tccggacgag attttgatgt ctcgtggagg cgagaaattg 480
gagtcggtta ttggtaggag tgaagatgat gagctgcccg tgttcaaaaa tggagctttt 540
cagattaaag ttactgataa actgaaaatt gggaaaaaat tagtggatga aaaaatcttg 600
aataaatact taccggaagg tgcaatttca aggcacacta tgcgtgaatt aattgactct 660
attcagttag ttggcgccga tgaatttcac tgttctgagg ttagattttg aaattttgct 720
tgatctttaa attaaaggtt tgaactttgt gaatgttggc agatatggaa tacaataatg 780
gattttgttt gatctgttta atgaagattg tctagaacct cattgttata aatatggttt 840
gtttgcttca ttaattaaag agcattcctt aaaatctcga ctagatgcca gataacacca 900
gttagttgac ttttggatta tggatttttt ttcatttaat cagataagat agtcattctt 960
aaatgtttca ctaaagaatt tgtcatgatt tcagtgtata tctttaagtg tatttggaat 1020
tttggatttg gatctagtac tgaatgggta actgcacttg tactccccag tcatctgggg 1080
aggagcaaca gattaaattc aagggttgaa aagtaataca gagtcagaaa ttaaccacaa 1140
gttggaaaat ggtaaatgta tgtggtctaa gatgattact cctataactt ttgatgtcta 1200
acatggagaa agttagttga tttatgctct ttacttttcc ctttattgat tttggttttc 1260
aaattctatc aattcctttg tttgattgct actcagattg aaccttagac ggagtagcaa 1320
tagaaaagtg aagaaaagcc attttttctc ctttcatctc tttatttctg ttttacacac 1380
agaatatggt agcatctgtc tgaactagtt aattttattc cttaaaattt gcataactaa 1440
ttcgagtaaa tgccttttga agctttagtt gtacaactgg ttgttgcatt ttgaggacta 1500
tcgacttgat ttgacagtgt ctgatacatg gcttgtaagt tatgaaaact tatatctagg 1560
aagaaatccc aaccagagat agggagctgt cgcttggtta tgagctactg gctcaaagtt 1620
cgagtttgac cagttaattt tagatcttcg gagtctaatc aaattctgaa gcagtattgt 1680
gcactaataa gaggaacaca tcaaggatgt agcactgcca ggttatgtta ccttatttac 1740
taatgattga gaaccagctt aaatgatgac aaatggtctt agatttgttt tttacattgc 1800
tcatgacttt gggatatttc tggatcaaca ttttccagtt ctttatgtac ttatcaaaaa 1860
attatccctg ctagagccta gatgttagtg ttcaagcaac catgctagct tttaaggaag 1920
ctccttcttt gattcatgcc atctttccgt aatcgatgcc ttacgttact gtcatttttc 1980
taattttcat ttcagtggat tgaggagccg tcacttttga ttacacgatt tgagtatgca 2040
aaccttttcc acacagttac cgattggtat agtgcatacg tggcatccag ggttactggc 2100
ttgcccagtc ggccacattt ggtttttgta gatggccatt gtgaggtatg tttgaaagta 2160
ttgataacga tggcatgcat tgtactgtgt tatggatgaa agaaatgaaa tcagcaatta 2220
ttttctagca ggcaatgctc ttgagatgct tgtgtcaaat tggtcagact taatcctgag 2280
tttccatttg tttcagcttt ctgtttgact gactacaata attgtcccaa tacctagttg 2340
ttccggttgg ctcattctta cttctattta cgtgtcactg tttctctgaa tggtcccttt 2400
gtggtgaaaa gtgcttttgc tatgaagaaa aactagcaaa gatttcattt ctgggacaat 2460
ttatttttac cttacatcac gtctcataaa attgcttcct attgcatact ttaattcttg 2520
gagagatgct ttaatgtgaa gaaagttctt tcactccact tttaattctt ggagagatgc 2580
tttaatgtga agaaagttct ttcactccac ttttaattct tggagagatg ctttaatgtg 2640
aagaaagttc tttcactcca cttttaattc ttggagagat gctttaatgt gaagaaagtt 2700
ctttcactcc actactgtaa gcttgctgca tgaattttac ttggccatat tgggggcgtg 2760
ttttgattta tcttcaaatt cattttcttc atgtaattct tttgagtaat ttttttttct 2820
gttttctgtt tgggaaaaaa ttcagacaca attggaggaa acatggaaag cactcttttc 2880
aagcctcact tatgctaaga actttagtgg cccagtttgt ttccgtcacg ccgttctctc 2940
gcctttggga tatgaaactg ccctgtttaa gggactgaca gaaactatag attgtaatgg 3000
agcttctgcc catgatttgt ggcaaaatcc tgatgataag agaactgcac ggttgtccga 3060
gtttggggag atgatcaggg cagcctttgg atttcctgtg gatagacaga acatcccaag 3120
gacagtcaca ggccctaatg tcctctttgt tagacgtgag gattatttag ctcacccacg 3180
tcatggtgga aaggtacagt ctaggcttag caatgaagag caagtatttg attccataaa 3240
gagctgggcc ttgaaccact cggagtgcaa attaaatgta attaacggat tgtttgccca 3300
catgtccatg aaagagcaag ttcgagcaat ccaagatgct tctgtcatag ttggtgctca 3360
tggagcaggt ctaactcaca tagtttctgc agcaccaaaa gctgtaatac tagaaattat 3420
aagcagcgaa tataggcgcc cccattttgc tctgattgca caatggaaag gattggagta 3480
ccatcccata tatttggagg ggtcttatgc ggatcctcca gttgtgatcg acaagctcag 3540
cagcattttg aggagtcttg ggtgctaa 3568
<210> 90
<211> 6032
<212> DNA
<213> Artificial sequence
<220>
<223> Ntab-FucT-A exemplary contig Ntab-K326_AWOJ-SS19752
<220>
<221> misc_feature
<222> (542)..(542)
<223> n is a, c, g, or t
<400> 90
atggcaacag ttgtgccaat tcaaagatta ccaagatttg aaggtgttgg gtcatcatca 60
cctacaaatg ttccccaaaa gaaatggtcc aattggctac ctctagtagt tgcacttgtg 120
gttatagttg aaattgcatt tctgggtcga ctagacatgg ctgaaaaagc caacctagtc 180
aactcttgga ctgactcatt ttaccagttt acgacgtcgt cttggtcaac ctccaaagtg 240
gaaattaatg aggctgggtt ggctgtgtta aggagtggtg agattgatcg gaatttggaa 300
actgggagct gtgaggagtg gttggaaagg gaggattctg tggagtattc tagagatttt 360
gacaaagatc caatttttgt tcatggcggc gaaaaggtga gattgtttct tgtatatgtt 420
tattcttttt actaataaat ggggtgaata gagcagaatg gatatagagg attcatatag 480
ttgaacacga atagtttggg aagttctatg cacttaagga tgtaatagtt tttttttttt 540
tntttttttt tttagtgatg agtgaagggc agccttgacg taaccggtaa agttgttgcc 600
atgtgagtca cggttttgag ccgtggaaac aaccttttgc agacatgcag ggtaaggcgg 660
cgtaaaatag acccttgtgg tccggctctt ctcggaaccc tacatagccg gagcttagcg 720
catcgacctg ccattttgat gatgagtatt ttgatgatga gtataagttc tatgcactaa 780
cgatgtaaaa tagatttaca ccattaggtc acttaaaagg tagtagcagc taattctcca 840
tggaaacatt aattggtaat cgagcatctc ttttagacta ttatatggat tttgttgcaa 900
tttatgtctt gttatttatt acatcagtta gctgccagag ctccagacat atggctttgg 960
tagatggaat gataaaaatt tgttgtttca aatgatgctt gggttttctt ctcgtttttt 1020
ttttgttctt atatcatgtt tacagtggaa tatcttataa agtacagact attgacaata 1080
ttccaaaacc tcttctatat gggtaaaaat actcatgaat tttatatact agtagggaat 1140
aaggggagga gccttgagta tcttcttttt ttcttacctt tttttccttc attacattga 1200
attcttcata gagcacttaa gtggaatgag cagaaatcaa tcagtaaaac tgccatttat 1260
tgcttgagtt tatcatgact agttcttgtt cccatgttat ccactggtat ataggtgaga 1320
gcaggtaaca gttactcggt taccatcttt cttcttgatt tttttccctt accatatgca 1380
aaaactgatg ttccttcgat cgttatctag gattggaagt cttgtgccgt aggatgtaac 1440
tttggtgtgg attctgataa gaagcctgat gcggcatttg ggacaccaca acaggctggc 1500
acggctagcg tgcttcggtc aatggagtct gctcaatact atcctgagaa caacatcatt 1560
accgcacgac ggtgggtaag cacatctaga aaaagactta aaacattctc accacatttg 1620
gcagcatttg tcgacaattg aattttcatc ttgtgatcat tttttaatga aacatatctc 1680
acttggaagt ttttgcttgc aattagtttc tgactagacc ttttttcttt ggataagtaa 1740
ggtagcatat tattagtaag cagtaccaag aaagtacaaa aattgatact tccaaagtct 1800
actcaaaacc tgaatccagc gactccaaga actcatttgt actaactaca agatccgttt 1860
tatgccagca aaagagatat tgtaaacatc tatacttcat aactataatc tcctcatttt 1920
ccccctcaaa atatctcata tttctttctt gccaaaccgt caaaacaata cacaaagaaa 1980
taagcttcca gatattcttc cctcttttct ccactgtgct tgccagctga tgagtgcacc 2040
tttgaaattt tgtggcatta cccagtatta cacccaaaat atatttttta tcaggatacc 2100
ctctaaatat taaggaataa agaccagata ctccaagaaa gattacgatg catcgggaga 2160
tgactaacag attcacatag acaatcctga tttgaaacca caactgatca cagttgggaa 2220
taaatctgta agtaaacctt cattacacca tctatcagtc caaagcttga ctttcctacc 2280
attttcaact ttttgtttta tgttgtcttt gaactgtccc tagaaattag ctattggtct 2340
ccccaaagca acctcataag gattacttac tggttttgga tcctaatatc tctccatgcc 2400
ataaattgac ttaataacag ccttccatac tgcatatttt ccatcgttac aaaaaaaagc 2460
agttgcattt gctcaaatag cctttggaaa gggcatctac aaacatgcaa tcataaagcc 2520
ctcaacaaca ataactacaa caacaaccta gtaaaatccc acaagtgggg tctggggagg 2580
gtagtgtgta cccaaacctt acccctaccc tgagggagta gagaggttgt ttccgataga 2640
ccctcggctc aagaagatga aaagagacaa tatatcagta ctatcaacag atcatagaga 2700
taataacagc aatcataaag gcctcataga cacaataacc ttaggatcat gttgtggtta 2760
taatttaatt tttagatctc ctatagttct tctctcaatc tttatatctt tctctaggga 2820
aatctctaac caactttatt attctttctc atgtttcaga aggggatatg atattgtaat 2880
gacaacaagc ctctcttcgg atgttcctgt tgggtacttc tcttgggcgg agtatgatat 2940
aatggctcca gtgcaaccta aaactgagaa tgcattagca gctgctttta tttctaattg 3000
tggtgctcgc aacttccggt tgcaggctct tgaagtcctt gaaagggcaa atatcaagat 3060
tgattctttt ggcagttgtc atcgtaaccg ggatggaaat ggtcagtgta tctccattat 3120
atatgataat atattgatgg ttcttttctt gaagtagtta ccattaagga gctaattgtc 3180
taaaatattt caatataatg tgtttttgaa aagccatgtt tactggtaat ggaaacctta 3240
tatttgtttc cttggtaaat gtacacatac acatgtaagt tttctaaata gtcagatttt 3300
ctgctagttt gaagagttca ttttgtggat tggttatttt gctgttatgc ttgttatttt 3360
ttgaatacct tcttagtatt ttgcaaccca ttaaattgag ttgaaaagcc gacagttttt 3420
gcaaattcat tgcaatgaaa ttagacccta atttgttata aaagaaaaat ttagagaaaa 3480
tttagtttta gtttattttt ctgatgtaga atatgcatgc atgtggttaa actttacatt 3540
atatgtaaat ttattagaat agagttgaaa agcagacatc tttttgtaaa tttattgtga 3600
agaagctaga ccagggtttg ttggaaaggg aaattaagag aaaaggcagt cttaataaat 3660
gtcatattag aatgcagaat atgtttattc atgcctctag tttaattgta cattatatcc 3720
tgtgaatgct cacttgtcat cttgttctca atttcatggc agtggacaaa gtggaaactc 3780
tcaagcgcta caaatttagc ttcgcttttg agaattctaa tgaggaggat tatgtcactg 3840
aaaaattctt ccagtcctta gtagctggta ataatttttg cctgttaatt ttggttctga 3900
tttgaacact tagtttccga tgtatctatt attttctatt agcccccacc cctctgcaat 3960
gatgcatttt gttttacttt ttctgcaatt cataattaca caaaagacat aggagatatt 4020
agctatagag cgccatgaag aacaaagcaa aaagcacaaa cttctgagca ctttatgtta 4080
cttcaactgc gttttgtacc cgaatttgca ttttctggta cggcacacaa atatgctctg 4140
ctttatattc atgtaaaagg ctttaggaaa attttaaatg attttacgtt aattatcatt 4200
gttaatcata ttctttgtgc tcctagtcga tatactttag gctagagtta tgcacagaat 4260
cctgttttta tgatttttca caagttacta cttcaaaatt atgatttatg gtagtcaacg 4320
ctattgtgct gataaaagga agttcatgta aacttgcagg atcagtcccc gtggtgattg 4380
gtgctccaaa catcctagat tttgctcctt ctcctaattc acttttacac attaaagagc 4440
tgaaagacgc tgcatcagtt gccaagacta tgaagtacct tgcagaaaat cctaatgcat 4500
ataatgagtc attaaggtat gcatcaatta gtcatgcttt tcttacgtgc tcttcttgat 4560
tatttgaatt ttcctgtcct aaattaactt ttttttgttt gtcctgaaga tttatccact 4620
ctctctaaaa aaaaacccct tttccaacat ctttctgtac ttttctgtta tcatgttatt 4680
gagaaagtag cactggcctg tctctatagt tacaaaagtt tattacctta tcctattttg 4740
acacactgat atatagtttt ggtctaacta aaactcctaa attgggaaga ttattccgtg 4800
tgtgtgagtg tgtgtcccct tctgcatgtg cggacttgca tttgaccttt tcctttcaaa 4860
atttattaaa gattcttaaa cttcctgggt cttgctaaca aatggtttct tttcattgtt 4920
taggtggaaa tttgagggtc catctgactc tttcaaagcc ctggttgaca tggcagcagt 4980
tcactcttct tgtcgtttgt gtatcttctt agcaactagt attagggaga aagaagagaa 5040
gagtccaaaa tttacgaaac gtccctgcaa atgtaccaga ggttcagaaa ctgtctatca 5100
tgtatatgta cgtgaaagag ggaggtttga catggagtct gttttcctaa ggtattctcg 5160
atctgccatg actaaatatc atgcatatac aagtgccttt tctgtttatg ttcctgtgcc 5220
gctgttctta tgtttaatat gtaccatgat gatcaaattg tttaccaata ttggaatgaa 5280
aaggatccga aaagagtgga atgtatatag aggattcgta gagctgaccg caaatagggg 5340
tgagacatat tgatcaaatt atttgagtaa ctactcactg tgtcttactc tcgatgtatg 5400
agaattgaga agtatatgct tggtagccat ggtctatggg cttataaagt agtttacatg 5460
tttgtggttg gatattccac aaaatcaatg tcaatctatc taaagtagtt cttgatcgat 5520
ttgatagact taactaggga agttccggaa aatatttggc aagtggtgtt tggttcacta 5580
gtaaagctag aagatagggc tggggggtta aagttggggg gatccggcca cgaaaaagaa 5640
atatggacaa ccaatgtcat aatgtgaatt ctctcctgca cttctccttt tactttctga 5700
gcatatacaa actgtttcat gtctcattgg caagtcttat gttatctttg aatcactgtt 5760
attgctggag cctttgcagg tcatctaatt tgtcactgga ggcttttgaa tctgcagtac 5820
tgtcaaagtt gaaatctcta aagcatgttc ctatttggaa agaagaaaga cctcaaatac 5880
ttcgtggagg ggatgaacta aagctctaca gagtatatcc tcttggcatg acacgacagg 5940
cattgtacac ctttagattc aaaggagacg ctgattttaa gaatcacatc gaaagccacc 6000
catgcgcaaa ctttgaagcc atatttgtat ag 6032
<210> 91
<211> 7189
<212> DNA
<213> Artificial sequence
<220>
<223> Ntab-FucT-B exemplary contig Ntab-BX_AWOK-SS16887
<220>
<221> misc_feature
<222> (2757)..(2757)
<223> n is a, c, g, or t
<400> 91
atggcaacag ttgtgccaat tcaaagatta ccaagatttg aaggtgttgg gtcatcatca 60
cctacaaatg ttccccaaaa gaaatggtcc aattggctac ctctagtagt tgcacttgtg 120
gttatagttg aaattgcatt tctgggtcga ctagacatgg ctgaaaaagc caacctagtc 180
aactcttgga ctgactcatt ttaccagttt acgacgtcgt cttggtcaac ctccaaagtg 240
gaaattaatg aggctgggtt ggctgtgtta aggagtggtg agattgatcg gaatttggaa 300
actgggagct gtgaggagtg gttggaaagg gaggattctg tggagtattc tagagatttt 360
gacaaagatc caatttttgt tcatggcggc gaaaaggtga gattgtttct tgtatatgtt 420
tattcttttt actaataaat ggggtgaata gagcagaatg gatatagagg attcatatag 480
ttgaacacga atagtttggg aagttctatg cacttaagga tgtaatagtt tttttttttt 540
tagtgatgag tgaagggcag ccttgacgta accggtaaag ttgttgccat gtgagtcacg 600
gttttgagcc gtggaaacaa ccttttgcag acatgcaggg taaggcggcg taaaatagac 660
ccttgtggtc cggctcttct cggaacccta catagccgga gcttagcgca tcgacctgcc 720
attttgatga tgagtatttt gatgatgagt ataagttcta tgcactaacg atgtaaaata 780
gatttacacc attaggtcac ttaaaaggta gtagcagcta attctccatg gaaacattaa 840
ttggtaatcg agcatctctt ttagactatt atatggattt tgttgcaatt tatgtcttgt 900
tatttattac atcagttagc tgccagagct ccagacatat ggctttggta gatggaatga 960
taaaaatttg ttgtttcaaa tgatgcttgg gttttcttct cgtttttttt tgttcttata 1020
tcatgtttac agtggaatat cttataaagt acagactatt gacaatattc caaaacctct 1080
tctatatggg taaaaatact catgaatttt atatactagt agggaataag gggaggagcc 1140
ttgagtatct tctttttttc ttaccttttt ttccttcatt acattgaatt cttcatagag 1200
cacttaagtg gaatgagcag aaatcaatca gtaaaactgc catttattgc ttgagtttat 1260
catgactagt tcttgttccc atgttatcca ctggtatata ggtgagagca ggtaacagtt 1320
actcggttac catctttctt cttgattttt ttcccttacc atatgcaaaa actgatgttc 1380
cttcgatcgt tatctaggat tgaaagtctt gtgccgtagg atgtaacttt ggtgtggatt 1440
ctgataagaa gcctgatgcg gcatttggga caccacaaca ggctggcacg gctagcgtgc 1500
ttcggtcaat ggagtctgct caatactatc ctgagaacaa catcattacc gcacgacggt 1560
gggtaagcac atctagaaaa agacttaaaa cattctcacc acatttggca gcatttgtcg 1620
acaattgaat tttcatcttg tgatcatttt ttaatgaaac atatctcact tggaagtttt 1680
tgcttgcaat tagtttctga ctagaccttt tttctttgga taagtaaggt agcatattat 1740
tagtaagcag taccaagaaa gtacaaaaat tgatacttcc aaagtctact caaaacctga 1800
atccagcgac tccaagaact catttgtact aactacaaga tccgttttat gccagcaaaa 1860
gagatattgt aaacatctat acttcataac tataatctcc tcattttccc cctcaaaata 1920
tctcatattt ctttcttgcc aaaccgtcaa aacaatacac aaagaaataa gcttccagat 1980
attcttccct cttttctcca ctgtgcttgc cagctgatga gtgcaccttt gaaattttgt 2040
ggcattaccc agtattacac ccaaaatata ttttttatca ggataccctc taaatattaa 2100
ggaataaaga ccagatactc caagaaagat tacgatgcat cgggagatga ctaacagatt 2160
cacatagaca atcctgattt gaaaccacaa ctgatcacag ttgggaataa atctgtaagt 2220
aaaccttcat tacaccatct atcagtccaa agcttgactt tcctaccatt ttcaactttt 2280
tgttttatgt tgtctttgaa ctgtccctag aaattagcta ttggtctccc caaagcaacc 2340
tcataaggat tacttactgg ttttggatcc taatatctct ccatgccata aattgactta 2400
ataacagcct tccatactgc atattttcca tcgttacaaa aaaaagcagt tgcatttgct 2460
caaatagcct ttggaaaggg catctacaaa catgcaatca taaagccctc aacaacaata 2520
actacaacaa caacctagta aaatcccaca agtggggtct ggggagggta gtgtgtaccc 2580
aaaccttacc cctaccctga gggagtagag aggttgtttc cgatagaccc tcggctcaag 2640
aagatgaaaa gagacaatat atcagtacta tcaacagatc atagagataa taacagcaat 2700
cataaaggcc tcatagacac aataacctta ggatcatgtt gtggttataa tttaatncaa 2760
ttatggaaaa accccataga gaaaccatca gggcccggtg ctttgtcagc tgcacatatc 2820
ttcaaggtct caaacacttc ttgttcttca aattctcctt gtagcaattc attatcttcc 2880
tatagttctc ctatagttct aattgtctct caatctttat atctttaaat ttaaatttta 2940
gatctcctat agttcttctc tcaatcttta tatctttctc tagggaaatc tctaaccaac 3000
tttattattc tttctcatgt ttcagaaggg gatatgatat tgtaatgaca acaagcctct 3060
cttcggatgt tcctgttggg tacttctctt gggcggagta tgatataatg gctccagtgc 3120
tacctaaaac tgagaatgcg ttagcagctg cttttatttc taattgtggt gctcgcaact 3180
tccggttaca ggctcttgaa gtccttgaaa gggcaaatat caagattgat tcttttggca 3240
gttgtcatcg taaccgggat ggaaatggtc agtgtatctc catataatat gatggttcat 3300
ttcttgaagt agttaccatt aaagagctaa atgtctagca tatttcaata taatgggttt 3360
gattctctct tcctcaagtg tattatatcc cttgaaaagc caattttact ggcaatagaa 3420
accttatatt tgtttccttg ctaaatggac acataccaat gcaagttttt taaatagcca 3480
gatgttctga tagtctaaag atttcatttt gtggataggt tattttgctg ttattcttgt 3540
tatctttttt tcttttggat aaggttaagt tttattaata ggagtaccaa gaaggtcaca 3600
taattatatc aaaagaaaga cagcaaacac tttttttatt tatcttttga atacctatta 3660
gtttgcaacc cattaaaata gagttgaaag cagacacatt ttgtaaattc attgcaaaga 3720
agctagttcc cgattagtta gaaaagaaaa atttagagaa aaggtagcct agataatttt 3780
tttttcccgg aatgcagaat atatttatgc atacatgtgg tttaactgta cgttagatat 3840
aaattcacgt agaatagagt tgagaagcag acattttttt agtaaatcca tcgtgaagaa 3900
gctagacctt ggtttattgg aaagagaaat gaagagaaaa ggtttttatc caacaaaaaa 3960
ataaaataag agaaaaggca gtcttgataa atctcatatt tgaatgcaga atatttttat 4020
gcatgcctct agtttaacag tacactagtt cttggacacg tgcgttgaat ccaaattata 4080
gatttattat atttaactca tcccgaaatt taatattcat aaagtaagtt ccaaaataac 4140
ataatgagtt actttagttt actttgctaa aaattgatta aattgatgcc tttaaaaaaa 4200
tacgataaaa caaatgatgg agagaaagaa gaggaataga aaaggattat gcggcttttg 4260
agttttaacc aaagcacaga aataattatt tagtaaaaaa ctaaggaaag agagagatca 4320
aggtgttttt agagattaat gaagggatgt ggctctttgt gtagtgcgat attataacag 4380
tggaagataa agaaacaaac aatcaatgaa taattaagat aattaaactc aaaaaaactt 4440
gtataaaaaa acaatcaatg cctacattca cccggttaaa agtaataaaa gtattcattt 4500
actggaaggt catttttttg gctcaaggat aaaattgtca ttcagttttt taaggttata 4560
ttagtaaatt aactttgagg ataggatgtt cccactttta gtataatatg attatatcct 4620
gtgaatgctc acttgtcatc ttgttctcaa tttcatggca gtggacaaag tggaaactct 4680
caagcgctat aaatttagct tcgcttttga gaattctaat gaggaggatt atgtcaccga 4740
aaaattcttc cagtctctgg tagctggtat taacttttgc ctgttaattt tggttctgct 4800
ttgtacgctt agtttctgat gtaggatctc ttattttctc tcagccccac ccctctacat 4860
tgatgcattt tgttctactt tttctgcaat gccatacttt cacaaagact ttgaagatat 4920
tagctataga gcgtgccatg aagaacaaat attgcaaaaa cacaaactta tgagcatttt 4980
atggtacttc aactacattt tgaacctgga tttgcatttt ctggtacagc gcacaaatat 5040
gctctgctct atattcattt aaaaagcttt aggaaaattt taaatgattt tacatgaatt 5100
atcattgttt aatcatattc tttgtgctca tagtcaatat attttaggct agatttatgc 5160
acagaatcct gtttttatga tgtttcacaa gttactactt caaaattaag atttatggtg 5220
gtcaactctg aagttcatgt aaacttgcag gatcagtccc tgtggtgatt ggtgctccaa 5280
acatcctaga ctttgctcct tctcctaatt cacttttaca cattaaagag ctgaaagacg 5340
ctgcatcagt tgccgagact atgaagtacc ttgcagaaaa tcctagtgca tataatgagt 5400
cattaaggta tgcatcaatt agtggtgctt ttcttacgtg ctcttcttga ttatttgaat 5460
tttcctgtcc taaataactt ttcattggtt gtcctgaaga tttatccact ctcaaagaac 5520
acctttttcc agcatctttc tgtacttttt cggtatcatg ttattgagaa aataacaaca 5580
gccctgtctg tatagttaca aaagtttatt accttatcct atttacatac tgatatattg 5640
ttttggtcta actaaaactc ctgaattggg aagattgttc tccttgtgtg tgtgtttccc 5700
ctctctgctt gtctggagtt gcaatttact ctttcctttc aaattttttt aaggatttct 5760
taaatttcct gtgtctggct aactaatgct ttttttcatt gtttaggtgg aagcttgacg 5820
gtccatctga ctctttcaaa gccctggttg acatggcagc agttcactct tcttgtcgtt 5880
tgtgtatctt cttagcaact agtattaggg agaaagaaga gaagagtcca gaatttacaa 5940
aacgtccctg caaatgtacc agaggttcag aaactgtcta tcatatatat gtacgtgaaa 6000
gagggaggtt tgacatggag tccattttcc taaggtattc tctatctgtc atgactaatt 6060
tctattcatg catatataag tgcattttct gtatatgttc atgtgccact gttcttgttt 6120
ttaatatgta ccatggcgat caaattattt acaagtattg gaatgaaaag ggtccgaaca 6180
gagtggaatg tacaacaaca acaacaacga cccgttaaaa tcccacaaag tgtgtgtaca 6240
caaaccttac ccataccccg atggggcaga gaggctatta ccgatagacc ctcgaccgaa 6300
tagagtggaa tgtatataga ggattcatat agctgatcgc aaataggggt tgaggcatag 6360
tgatgaaatt gcttgagtaa ttattcactg tgtcttacta tcaatgtatg agaagtatat 6420
ggcttggctg agagcccatg gtctatgggc taagttgctt ggatacaggt gcgggtgtcc 6480
gacacgggtg cggatctaga tatcagattc ttcgagatat aaattttaag attcggggat 6540
atggatccta ttactagtag ggatatgagt gcggagatcc ggctaaaaat aatacaaaaa 6600
attaataata taaaagtact ctaaattatg agaaattttg tggaatactt agcttgtaaa 6660
gtgtggattt ctttattctc aagttgtaaa agattgattt cctagataag gtatgctatt 6720
tttttcaaaa ttacccttgc tagaagatgg ggttagcggg ttaaagttgg gggggattca 6780
accgtgaaaa agaaatatgg acagcagata tcataatgtg aattctctcc tgcacttctc 6840
cttttacttg cttagcatat acaaactgtt tcatgtctta ttgtcaagtc ttatgttatc 6900
tttgaataac cgttattgct ggaacctttg caggtcatct aatttgtcat tggaggcttt 6960
tgaatctgca gtactgtcga agttcaaatc tttaaagcat gttcccattt ggaaagaaga 7020
aagacctcaa atactacgcg gaggggatga actaaagctc tacagggtat atcctctcgg 7080
catgacacaa cgacaggcat tgtacacctc cagattcaaa ggagacgccg attttaggaa 7140
tcacatcgaa agccacccat gtgcaaattt tgaagccata tttgtatag 7189
<210> 92
<211> 9264
<212> DNA
<213> Artificial sequence
<220>
<223> Ntab-FucT-C exemplary contig Ntab-K326_AWOJ-SS16744
<400> 92
atggcaacag ttattccaat tcaaaggtta ccaagatttg aaggtgttgg gtcatcatca 60
cctacaaacg ttccccttaa gaaatggtcc aattggctac ctctagtagt tgcacttgtg 120
gttatagttg aaattacatt tctgggtcga ctggacatgg ctgaaaaagc caacctggtc 180
aactcttgga ctgactcatt ttaccagttt acgacgtcgt cttggtcaac ctccaaagtg 240
gaaattagtg agactgggtt gggtgtgttg aggagtagtg aggttgatcg gaatttggaa 300
actgggagct gtgaggagtg gttggaaaag gaggattctg tggagtattc tagagatttt 360
gacaaagacc caatttttgt tcatggcggc gaaaaggtga tatagttttc ttgtaaatgt 420
ttattttttt tttagagcag aatgaatata gaggattctt atagttgaac ccgaacagtt 480
taggaggcat agttgattgc tctttttttg atgatgcgta ttagttctat acaggggatt 540
cttggagtaa cggtaaagtt gtctccgtag gtcacaggtt cgagccgtgg gttcgagccg 600
tggaatcagc cacgatgctt gcatcagggt aggctgccta cattataacc ccttcgtgca 660
ccggactact gccctttagt attagttcta ggcactaacg atgcaaaaaa gatttacgcc 720
ataaggtcac ttaaaaggta gtagcagcta attctccata gaaacattaa ttggtgatcg 780
agcatctctt ttagacgata atttgaattt tgttgcaatt tatgtcttgc tatttattac 840
atcagttagc tgccagagct cgtgtgtgtg tgtgtgtgtg tgtgtgtgtt ccagacttgt 900
ggctttggta ggtggaatga taaaaaaatt gttgtttcaa atgatgcttt ggcattttct 960
tctagctttt ttgttctttt atcatgttta cggtcaaaca tcttataagg actattgacc 1020
atattccaaa accgattata tgggtaaaaa tactcatgaa ttttatatac tagtagggaa 1080
taagtggagg agccttgaat atcttctttt ttcttacctt tttttccttc attacattga 1140
attcttcata gagcacttaa atggaatgag cagaaattaa tcagtaaaac tgccatttat 1200
tgcttaagtt tatcatgagt agttcttgtt cccatgttat ccactggcat gtagtgagag 1260
caggtaacag ttacctggtt accatctttc ttcttgattt ttttttcctt accatatgcg 1320
aaaactgatg ttccttcaat cattatctag gattggaagt cttgtgccgt aggatgtaac 1380
tttggtgtgg attctgaaaa gaagcctgat gcggcatttg ggacaccaca acaggctggc 1440
acggctagcg tgcttcggtc aatggagtca gctcaatact atcctgagaa caacatcgtt 1500
atggcacgac ggtgggtaag cacatcttga aaaagattta aaacattctc acctacattt 1560
ggcacctgaa agataatagc atttgccaca tttgagtttt catcttgtga tcgtatctta 1620
atcaaacata tctcacttgg aagtttttgc ttgctattag tttctgacta ggcctttctt 1680
ttaaggagca tattattagt aagcagtacc aagaaggtac caaaaaagta caaaaattta 1740
gacttccaaa gacaactcaa aacccgaatc tagtgagttg aagaactcat ttgtactaac 1800
tagaggatcg gttttatgcc agcaaaagag atactgtaaa catctattct ttataactga 1860
attatgctcc tttcccccct caaaatatct cgtgtttctt tcttgacaaa atctccaaat 1920
aatacacaaa ggaataagct tgcagatctt cttcagtctt ttctccactg tgcttgccag 1980
ctgatgagtc cacctttgaa atttgtggca ttacccagta ttacccccaa aatatatttt 2040
ttatcagtat accctcaaaa tattaaggaa taaagaccag ctactccaag aaagattacg 2100
atgcatcagg agatgactaa cagattcaca gacaatcctg atttggaacc acactgaaca 2160
cggctgagaa taaatctata agtaaacctt cattacacta ttcatcactc caaagcttga 2220
ctttcccatc attttcagct tttagtttta tgtttatctt tgaactgcct ccaaaaatta 2280
gctattggtc tccacaagca acccataagg attacttact ggttttggat tctaatatct 2340
ctccatgcca taaatcggct ttataacagc cttccatact gcatattttc tatcattacg 2400
aaaaaaaagc agttgcattt gctcaaatag cctttggaaa gggcatctac aaatatgcaa 2460
tcataaagcc ctcatagaca ataatcttag gatcatgttt ttttttatga taatggtaac 2520
atatatatta ataaataaaa cagcactaga gcagtgccaa gccatattta caagaaaaca 2580
gaaaccagct atgacaacct aagattacag tgcacctatc aggtctacta aagattctgc 2640
ctcctctatc cagttttctt tacaccagaa ataaaacaaa agtaaacact tcatcttgat 2700
gttctgtaaa gaattgcttc tgtcttcaac agttcttaaa tttctctcct tccagactgt 2760
ccaccatatg cacgcaggaa ccaatcgcca ccatttcttc tgtctcacta taccctcatt 2820
gtaattccaa cacttcaaca tatcacaagt gttagctggc atgctccatt taaggcccac 2880
aatattaaga aatagttgcc acagttggtc agtaaaagga caatgaagaa acaaatggct 2940
attagtttct atagctgtac cacataatag gcatttagag catagctgaa aacctcttct 3000
tctcaagttc tcttgggtta gacaagcctt tcttgtaact aaccatgaaa agcataccac 3060
cttgaaaggt gcctttactt tccaaatatt cctccagggc cattgttcta actgttggtt 3120
tgaagcagcg agtagagtat acgcggatct gaccgtaaaa ttcccactcc ttcaatgatt 3180
ccagcatagt ttatcttcag tttctccaag accttggaat tgttccaaga tattaaagaa 3240
atttacaacc ctttctaatt cccaatcatt caaggccttt ctaaaagtaa cattccatcc 3300
ttgctgaccc caggcagtgt ctaaagtgga tgtaggtgat gttgcaatgc tgaaaaattt 3360
ttgaaaaaat tctttgagag gaccatgtcc taaccagtta tcactccaga aaagtgtttt 3420
ccttccatta ccaaccttta tggttgtatt atcagccaga gtattccagt gaagtctgat 3480
tgacttccat accccaaccc catgtgaact attaacagag ttagagcacc atagtccatt 3540
ttgtccatac ttgtcacaga tgacctttct ccacaaagca ttagccttca gattgtacct 3600
ccaaagccac ttcaagagta aactctgatt gtgggcttta aggttcctaa tgcccaaacc 3660
ccctttgtct ttgcttgtga taagggaatt ccagttaact aaatgaatag cttccttctc 3720
tctgtttcct tgccatataa agctccttct tagtgcatca attcttttcc tcaccttgct 3780
tggtaaggga aacaaagaca ttacacatgt aggaagtgca tccaagacac tattaaccaa 3840
taccaccctt ccacccaagg ataaatactg gctcttccag gttgatagcc ttttttcaca 3900
tctttcaaga accccattcc atatttcttg agctttgttc ttggagccta gagataaatc 3960
caaatatata gttggtagag aacccacctc atatcccagt atagctgcta gggcctggat 4020
atcatccact tctttaactg ggaacaacat gctcttcctc caatttacat ggagccctga 4080
gactgcttca aatataacaa gaatgactct tagatatttt agttgatctg cctttgcctc 4140
acaaaaaact aaagagtcat cagcatatag aagatgggtg atctccacac tatctccctc 4200
cctgtttgaa gctttaaaac ctttcagcca accattgttg tttgcatttc ttaacatttg 4260
gttcaatcct tccatagcaa agaggaaaag aaaaggtgat aagggatccc cttgtctcaa 4320
acctctctca gaaggaaaaa atccctctgg agaaccattc accaaaatgg aaaatctgac 4380
tgttctgatg cagaaagata tccagttgat ccacttccta ccaaaaccca tatcctgaag 4440
aactttgagt aaaaagttcc aattaacatg atcataggcc ttctcaatat caagcttaca 4500
gagaattccg ggaacctgcc cttttaagtc aggaatccac acattcattt gcaatcaagg 4560
aagcatccat gatttgcctg cctcttatga aggccatttg atgcccattc actagtttgt 4620
ccaccacttt cttgagcctc tctgtcaata gtttggaaat gatcttgtaa atgcttcctg 4680
taagactaat tggtctgaag tccttgagtt ccttagcacc attctttttt ggaataaggg 4740
ctatgtaagt agcattgaaa ctcttctcaa aatattcatt gttgtggaag tttctgatgg 4800
tatgcatgat gtcttctttc acaatctccc agcaattatg gaaaaacccc atagagaaac 4860
catcagggcc cggtgctttg tcagctgcac atatcttcaa ggtctcaaac acttcttgtt 4920
cttcaaattc tccttgtagc aattcattat cttcctatag ttctcctata gttctaattg 4980
tctctcaatc tttatatctt taaatttaaa ttttagatct cctatagttc ttctctcaat 5040
ctttatatct ttctctaggg aaatctctaa ccaactttat tattctttct catgtttcag 5100
aaggggatat gatattgtaa tgacaacaag cctctcttcg gatgttcctg ttgggtactt 5160
ctcttgggcg gagtatgata taatggctcc agtgcaacct aaaactgaga atgcgttagc 5220
agctgctttt atttctaatt gtggtgctcg caacttccgg ttacaggctc ttgaagtcct 5280
tgaaagggca aatatcaaga ttgattcttt tggcagttgt catcgtaacc gggatggaaa 5340
tggtcagtgt atctccatat aatatgatgg ttcatttctt gaagtagtta ccattaaaga 5400
gctaaatgtc tagcatattt caatataatg ggtttgattc tctcttcctc aagtgtatta 5460
tatcccttga aaagccaatt ttactggcaa tagaaacctt atatttgttt ccttgctaaa 5520
tggacacata ccaatgcaag ttttttaaat agccagatgt tctgatagtc taaagatttc 5580
attttgtgga taggttattt tgctgttatt cttgttatct ttttttcttt tggataaggt 5640
taagttttat taataggagt accaagaagg tcacataatt atatcaaaag aaagacagca 5700
aacacttttt ttatttatct tttgaatacc tattagtttg caacccatta aaatagagtt 5760
gaaagcagac acattttgta aattcattgc aaagaagcta gttcccgatt agttagaaaa 5820
gaaaaattta gagaaaaggt agcctagata attttttttt cccggaatgc agaatatatt 5880
tatgcataca tgtggtttaa ctgtacgtta gatataaatt cacgtagaat agagttgaga 5940
agcagacatt tttttagtaa atccatcgtg aagaagctag accttggttt attggaaaga 6000
gaaatgaaga gaaaaggttt ttatccaaca aaaaaataaa ataagagaaa aggcagtctt 6060
gataaatctc atatttgaat gcagaatatt tttatgcatg cctctagttt aacagtacac 6120
tagttcttgg acacgtgcgt tgaatccaaa ttatagattt attatattta actcatcccg 6180
aaatttaata ttcataaagt aagttccaaa ataacataat gagttacttt agtttacttt 6240
gctaaaaatt gattaaattg atgcctttaa aaaaatacga taaaacaaat gatggagaga 6300
aagaagagga atagaaaagg attatgcggc ttttgagttt taaccaaagc acagaaataa 6360
ttatttagta aaaaactaag gaaagagaga gatcaaggtg tttttagaga ttaatgaagg 6420
gatgtggctc tttgtgtagt gcgatattat aacagtggaa gataaagaaa caaacaatca 6480
atgaataatt aagataatta aactcaaaaa aacttgtata aaaaaacaat caatgcctac 6540
attcacccgg ttaaaagtaa taaaagtatt catttactgg aaggtcattt ttttggctca 6600
aggataaaat tgtcattcag ttttttaagg ttatattagt aaattaactt tgaggatagg 6660
atgttcccac ttttagtata atatgattat atcctgtgaa tgctcacttg tcatcttgtt 6720
ctcaatttca tggcagtgga caaagtggaa actctcaagc gctataaatt tagcttcgct 6780
tttgagaatt ctaatgagga ggattatgtc accgaaaaat tcttccagtc tctggtagct 6840
ggtattaact tttgcctgtt aattttggtt ctgctttgta cgcttagttt ctgatgtagg 6900
atctcttatt ttctctcagc cccacccctc tacattgatg cattttgttc tactttttct 6960
gcaatgccat actttcacaa agactttgaa gatattagct atagagcgtg ccatgaagaa 7020
caaatattgc aaaaacacaa acttatgagc attttatggt acttcaacta cattttgaac 7080
ctggatttgc attttctggt acagcgcaca aatatgctct gctctatatt catttaaaaa 7140
gctttaggaa aattttaaat gattttacat gaattatcat tgtttaatca tattctttgt 7200
gctcatagtc aatatatttt aggctagatt tatgcacaga atcctgtttt tatgatgttt 7260
cacaagttac tacttcaaaa ttaagattta tggtggtcaa ctctgaagtt catgtaaact 7320
tgcaggatca gtccctgtgg tgattggtgc tccaaacatc ctagactttg ctccttctcc 7380
taattcactt ttacacatta aagagctgaa agacgctgca tcagttgccg agactatgaa 7440
gtaccttgca gaaaatccta gtgcatataa tgagtcatta aggtatgcat caattagtgg 7500
tgcttttctt acgtgctctt cttgattatt tgaattttcc tgtcctaaat aacttttcat 7560
tggttgtcct gaagatttat ccactctcaa agaacacctt tttccagcat ctttctgtac 7620
tttttcggta tcatgttatt gagaaaataa caacagccct gtctgtatag ttacaaaagt 7680
ttattacctt atcctattta catactgata tattgttttg gtctaactaa aactcctgaa 7740
ttgggaagat tgttctcctt gtgtgtgtgt ttcccctctc tgcttgtctg gagttgcaat 7800
ttactctttc ctttcaaatt tttttaagga tttcttaaat ttcctgtgtc tggctaacta 7860
atgctttttt tcattgttta ggtggaagct tgacggtcca tctgactctt tcaaagccct 7920
ggttgacatg gcagcagttc actcttcttg tcgtttgtgt atcttcttag caactagtat 7980
tagggagaaa gaagagaaga gtccagaatt tacaaaacgt ccctgcaaat gtaccagagg 8040
ttcagaaact gtctatcata tatatgtacg tgaaagaggg aggtttgaca tggagtccat 8100
tttcctaagg tattctctat ctgtcatgac taatttctat tcatgcatat ataagtgcat 8160
tttctgtata tgttcatgtg ccactgttct tgtttttaat atgtaccatg gcgatcaaat 8220
tatttacaag tattggaatg aaaagggtcc gaacagagtg gaatgtacaa caacaacaac 8280
aacgacccgt taaaatccca caaagtgtgt gtacacaaac cttacccata ccccgatggg 8340
gcagagaggc tattaccgat agaccctcga ccgaatagag tggaatgtat atagaggatt 8400
catatagctg atcgcaaata ggggttgagg catagtgatg aaattgcttg agtaattatt 8460
cactgtgtct tactatcaat gtatgagaag tatatggctt ggctgagagc ccatggtcta 8520
tgggctaagt tgcttggata caggtgcggg tgtccgacac gggtgcggat ctagatatca 8580
gattcttcga gatataaatt ttaagattcg gggatatgga tcctattact agtagggata 8640
tgagtgcgga gatccggcta aaaataatac aaaaaattaa taatataaaa gtactctaaa 8700
ttatgagaaa ttttgtggaa tacttagctt gtaaagtgtg gatttcttta ttctcaagtt 8760
gtaaaagatt gatttcctag ataaggtatg ctattttttt caaaattacc cttgctagaa 8820
gatggggtta gcgggttaaa gttggggggg attcaaccgt gaaaaagaaa tatggacagc 8880
agatatcata atgtgaattc tctcctgcac ttctcctttt acttgcttag catatacaaa 8940
ctgtttcatg tcttattgtc aagtcttatg ttatctttga ataaccgtta ttgctggaac 9000
ctttgcaggt catctaattt gtcattggag gcttttgaat ctgcagtact gtcgaagttc 9060
aaatctttaa agcatgttcc catttggaaa gaagaaagac ctcaaatact acgcggaggg 9120
gatgaactaa agctctacag ggtatatcct ctcggcatga cacaacgaca ggcattgtac 9180
acctccagat tcaaaggaga cgccgatttt aggaatcaca tcgaaagcca cccatgtgca 9240
aattttgaag ccatatttgt atag 9264
<210> 93
<211> 5137
<212> DNA
<213> Artificial sequence
<220>
<223> Ntab-FucT-D exemplary contig Ntab-K326_AWOJ-SS19661
<400> 93
atgagatctt cgtcaaattc aaacgcaccc aataaacaat ggcgcaattg gttgcctctg 60
ttctttgccc tagtggttat agcagagatt tcttttctgg ttcgactcga cgtggctgaa 120
aaagccaact cttgggccga ctcgttttat cagttcacca cagcctcttg gtccacctct 180
aaactggctg ttgaccacgg cgacgttgag gaggtccagt tgggtatttt gagtggtgag 240
tttgatcagg gcttcgtacc cgggagttgc gaggagtggt tggaaaggga agattctgtg 300
gcttattcga gggattttga taatgaacca atttttgttc atgggcctgg acaggttata 360
accacttcta tttatgactg aatattgaat attgatataa ttggacttat tagttcggga 420
ttgagccata gtcgtatttc tttttctttt tcttttcttt ttcttttttc gtccgttgtt 480
tgtggcatgc ctaaatctct tttaatgtgt ttatttattt ttgtggattt tatcgtaatt 540
cctagtgtta gataatcctt aaatacaggg tattgaaata ttatggaccc gaatagagca 600
attatgatat tgaggattca tacagccgac tccagctagt ttgggataga ggcgtggtag 660
tagtagtagt tgttgttgtt gttgcaaaaa aatgtattgg catctcagta tgcgtaaggt 720
gcatggttga tttcagactt ttgactatta ttgtagctgg gtcatagcaa gagaggtttg 780
cttagttgat ggattttagt tttttagctt cgtttgcttg gagcttttca taaggactag 840
agtttctaat acttttattt aaaaagggga aagagcagag aagcattgtg aattttcata 900
ttgattgcct tttgaagcat atagtcgttc agtattcctt tacttatttc ataaaaataa 960
catgctaatg gaatgatcag aaatcaattt atcataatgc gaataccact tcttattgtt 1020
cttggtctct catgctattc gcttgtgagt ttgaatgttt aactgttagg cattacttat 1080
ctctggcttt atgaatgtcc tgccctatac gaaattctga tgtctattca atgattcaat 1140
cactatatag gaattgaaaa cctgttccgt aggatgtaag tttggaacag attccgataa 1200
gaagcctgat gcagcatttc ggctaccaca acaagctggt acagctagtg tgctacggtc 1260
aatggagtca gctcaatact atgcagagaa caacattact ttggcacgac ggtgggtaag 1320
cacattgtga aagaagtctt atttcattcc ctgcctttat tggcaatttt ctttttaata 1380
tttgttgtca ttctctttca tttttatcac attcttattt aagttatgta ttgctattag 1440
ttttcccttc caggggtggg ggtaaggctg cgtacatctt acggtcttac cctctccaga 1500
cctactgggt ttgttgttgt tgttgttgtt gttgttgttg ttgttgtatt gctattagtt 1560
ttagttaaga acttttgcat tataagtata ttggcagcta taggtccttg accaaacttt 1620
tgccatagac aagatattta aaaactgatg acatgaattc tttcccttta ggcactaaat 1680
atatttcctg tagaaaatag ttaagattca ccttgactga atcatcgctg acactgcttt 1740
ttgttgtttt aatctggctg ggttcctttc tctttttctt cattccgtta gggcaaaaaa 1800
ataggaactc tgcttttcaa ttggggagtt tttgggatgg agtggatcac caaccatact 1860
tattgaagct aatttagagc taaagatgct aaagtacgtt tttgataagt cataatgtga 1920
atgtactagc tttggttatt taaccgcaca agtcaaacta gaacttagtt ttgacatggt 1980
ataagtcaaa ttcttcctat tttacttata tagaagttct tctccttttg tttactttat 2040
aaagggtata agatgataaa tatattgtct actcttgggg gtctttgggt atgctaaatg 2100
agctaagagg tgtttagaac tctagcaagg attttcatga cgtattaagg acatgatcag 2160
aacccatgtt cagtgtttgc acagggttat caccaactaa tggtcaatga gcacatctaa 2220
tctagtttaa tgtttgagtt attggattga cttttcaata tcaataaacc attggccaaa 2280
tttcatgata ttttactgag ccatctgtaa tatgatgtcc aaccatgcct attcaataaa 2340
atgaaaattt taaaacttac agaattagtt gagcgccacc agatacttaa agctatgcca 2400
actgcgtcta acagaagttg aaagacgaag ttgagtgaga gcactgtttt tgatgtgtgg 2460
attaggtgca tgtcacaagt tcgaaccctg tagcagacaa aatcctggta tttacgtgga 2520
gaaggataga gagctgggcg tattatccat tgagtttcga accgtgcgtc actagccctt 2580
agggatttcg gtcaacaaca acaacaacaa caacaacaac aacaacaaca tacctagtaa 2640
tttcccataa gtggggtctg gcgagggtag aatgtacgca gccttacccc taccctggaa 2700
gggcagagag gctgtttccg atttcggtta tcataaaata aaaaaaaaag gttgaaacac 2760
aaagctaatt tttctatcac aaaaatcttt gaatttcatt gtagttgaga ttttggcatc 2820
accttgctta aaaaattagc ttagcatata gacatagata tttaaagcta tgccagttgc 2880
catgatagag tttaaaatta tcttggttag ttggttagtg ctcttcgtta cattgagtca 2940
cacgattaat ttatgaagcc aaagttctta aggaccatgg cgtggttgag atttaaactt 3000
tgcataagct tgctaaccaa ttttattttt ttcactcaca taccagaagg ggatatgatg 3060
ttgtaatgac aacaagcttc tcttcagatg ttcctgttgg atacttctct tgggctgagt 3120
atgatatcat ggctccagta caacctaaaa cagagaatgt cttagcagcc gctttcattt 3180
ctaattgtgg tgctcgcaat ttccgcttgc aagctttaga agcccttgaa agggcaaata 3240
tcagaattga ttcttatggc agttgtcatc ataacaggga tggaagaggt tagtatattt 3300
caattatcca aacttactga aggattagag gatagaatac ggatggtgca attttaagca 3360
gtgtcactag ggagctaatt cttgtccata gagtagtatt atgggtttga ttgactcttc 3420
ctcgggtatc acaccttcct ccagaagaca ggattttact accagtgcaa accttttttt 3480
tctctcctgg ctaatgtgag cacgcatgtc gtcgtttttt tagtgatttg aatttatgct 3540
agtccaatga ttgcttgtca atggattatt ttgctctttt tcttgtttaa aatttgagtt 3600
tcaattttgc cacctgataa gaataaagtt ggaatacaac attcatttaa atagttcgat 3660
ttcattctga ggaagttagg ctgagatttg ttggaaagag acgtatagcg agaaaaaatg 3720
ttgtggacaa atcatctttc tggatgccgt gtattttata catgcatttg gtttagggtt 3780
gcactaatat ccaactgaat tgcgttattt gtcaataaaa aatttccaat gaaatctaac 3840
ttctggtctc tgttctcaat ctgatggcag ttgacaaagt ggaagcactg aagcggtaca 3900
agtttagctt ggcttttgag aattctaatg aggaggacta tgtaactgaa aaattctttc 3960
agtctctggt agctggtaat tacatttgtt ttttcttatt gggtttgtag acttggattt 4020
tcagagttga gagcatctat tattttagct cagtccctcc cttaacatga tagatacatt 4080
tgttcctagt tgtatttgat gtggttttgg ttagatcttc tgcgtttact agcagacctt 4140
ggaattgtag tatctaaagc gtacaattat ttatagaagt ttcaggaagg acaaacttct 4200
gagttctgat aaattcttga tacattcaac aatggtttgg atctagactt gcatttctgt 4260
agaatgcaca atgtgctcta cactgagatg gctcaaatat ttttggaatt ttgttgagat 4320
gattttaggg gtatgtctta gttgagcatt ttctttatgc tctaagacta aattctcttt 4380
ttcgaggtct atcccatgtt taagattttg acaattttat tagttcagaa ttgagattta 4440
aggtttcaac ttgctgataa aagtaagtct ataaaacttg taggatcaat ccctgtggtg 4500
gttggtgctc caaacatcca agactttgct ccttctccta attcagtttt acacattaaa 4560
gagataaaag atgctgaatc aatcgccaat accatgaagt accttgctca aaaccctatt 4620
gcatacaatg agtcattaag gtatgcgtca ataagaattg ttgttgttgt ttgtttgtgt 4680
tttttttttt gtttttttgt ttttgttact ccagttgttt acttgataat gggatggtac 4740
tcttcttaat tgttcgattt cctgtttttt gcaattacac actgtccaaa tctctctctt 4800
ttttaagcca tttggtacct tttgaaaata gtattacgaa gaaaatatta cagacccatt 4860
tcactaaaat gttttcacta ctgtatttcc agttttgacc aatttatata tagatattgc 4920
cttttgatgt taggtggata actgaattga acgagaacac aatggatctc tctgtttttc 4980
tgtaattaca agcaacttct tccctttcaa gattttactt aatatttctt aaatttactg 5040
gacatctaac aaatgattta ctttaattgt tcagatggaa gtttgagggc ccatctgatg 5100
ccttcaaagc cctggttgat atggcagcag ttcattc 5137
<210> 94
<211> 6639
<212> DNA
<213> Artificial sequence
<220>
<223> Ntab-FucT-E exemplary contig Ntab-K326_AWOJ-SS19849
<400> 94
ggctatagct attccaattc aaagttttcc tagcacccac ctcaatgtca aattcaaacg 60
cacccaataa acaatggcgc aattggttgc ctctcttcgt tgccctagtg gttatagcag 120
agttttcttt tctggttcga ctcgacgtgg ctgaaaaagc caactcttgg gccgactcgt 180
tttatcagtt caccacggcg tcttggtcca cctctaaact gtctgctgac cacggcgacg 240
ttgaggaggt ccagttgggt gttttgagtg gtgagttatt gagtggtgac tttgatcagg 300
gcttcgtacc tgggagttgc gaggaatggt tggaaaagga agattctgtg gcttattcga 360
gggattttga taatgaacca atttttgttc atgggcctgg acaggttata accacttcta 420
tttatgactg aattttatga agaattaacc caaatagccg tccaccaact gcttaaacta 480
aaattagccg gtagaggtat aatatatgca taatttatgt attatatgtg tataatgaac 540
gtataatggc taaaaaacgt aaaaaatgaa tatgaccagc tatttatgta aagatcccta 600
ttgaatattg atataattgg acttactagt tcgggattga gccatagtcg tatttttttt 660
ttccgtccgt tgtttgtggc atgcctaaat ctcttttaat gtgtttattt atttttgtgg 720
attttatcgt tattcctagt gttagataat ccttaaatac agggtattga aatattatgg 780
acccaaatag agcatttatg atattgagga ttcatacagc cgactccagc tagtttggga 840
tagaggcgtg gtagtagtag tagtagttgt tgatgttgca aaaaaatgta ttggcatctt 900
agtatgcgta aggtgcatgg ttgatttcag gcttttgact attattgtag ctgggtcata 960
gcaagagagg tttgcttatt gatggatttt agttttttag cctcgtttgc cgtgacatat 1020
taataagtgc tagagtttct aatcccttta ttcaaaaatg gggaaagagt agaggagcat 1080
tgtgaatttt catattaatt gcctttcgga gcatatattc gttcagcaat ttatttcatc 1140
acaaaaataa cgcgctaatg gaatgatcag aaatcaattt atcataatgc aaatacggcc 1200
tcttattgtt cttggtctcg catgctattc aattgtgtgt ttgaatgttt aattgttagg 1260
cattacttat ctctgacttt atgaatgtcc tgccctatac ggaattctga tctctattca 1320
atcactatat aggaattgaa atcctgttcc ataggatgta agtttggaac agattccgat 1380
aagaagcctg atgcggcatt tcggctacca caacaagctg gcacagctag tgtgctacgg 1440
tcgatggagt cagctcaata ctatgcagag aacaacatta ctttggcacg acggtgggta 1500
agcacattgt gaaagaagtc ttaattcatt ccctgccttt attggcaatt ttctttttaa 1560
aatttgttgt cattctcttt catatttatc acatttaagt tatgtattgc tattagtttt 1620
agataagaac ttttgcatta taagtatatt ggcagctata ggtccttgtc caaaattttg 1680
ccatagacaa gatatttgaa aactgatgac atgaattatt tccctttagg cactaaatat 1740
atttcctgta gtaaatagct aagattcacc ttgactgaat catcgctgac cctgcttttt 1800
gtcgttttaa tctggctggg ttcctttctc tatttcgtca ttccgttagg gcaaaaaata 1860
ggaactctgt ttttcaatcg gggagttttg gggatggagt ggaccaccaa ccatacttat 1920
tgaagctaat ttagagctaa agatgttaaa gtacgttttt gataagtcat aatgtgaatg 1980
tactagcttt ggatatttga ccgcacaaat caaactagaa cttagtttcg acatggtata 2040
agtcaaactc ttcctatttt acttatatag aagttcttct ccttttgttt actttataaa 2100
gggtataaga tgataaatat attgtctact cttgggggtc tttgggtatg ctaaatgagc 2160
taagaggtga ttagaactct agcaaggatt gtcatgatgt attaaggaca tgatcagaac 2220
ccatgttcag tgtttgcaca gggttatgca ccaactaatg gtcaatgagc acatctaatc 2280
tagtttaata tttgagttgt tattggattg acttttcaat atcaataaac cattggtcaa 2340
atttcatgat attttactga gccatctgta atatgatgtc caaccatgcc tattcaacaa 2400
aatgaaaatt ttaaaactta cggaattagt tgagcgccac cagatactta aagctatgcc 2460
aactgcgtct accagaagct taaagacaaa gttgagtaag agcacagttt ttgatgtgtg 2520
gattaggtgc atgtcacaag ttcgaaccct gtaacagaca aagtcctagt atttaagtgg 2580
agaagggtag atggttgggc gtattatcca ccgagtttcg aaccgtgcgt cactagccct 2640
tagggatttc ggttatcaac aacaacaaaa tacccaataa cttcccacaa gtggggtctg 2700
gcgcccacaa gtggggtctg gcgaggataa gatgtacgca gccttaccct taccctggaa 2760
gggcagagac gctgttttcg attttaggta tcataaaatt tttaaaaaaa aaaaaagttg 2820
aaacacaaag ctaatttttc tatcacaaaa atctttgaat ttcattgtag ttgagatttt 2880
ggcatcacct tgcttaaaaa attagcttag catatagacc tagatattta aagctatgcc 2940
agttgccatg atagagttta aaattaccct ggttagttgg ttagtgctct tcgttacatt 3000
gagtcacaag attaatttat gaagccaaag ttcttaagga ccatggcgtg gttgagattt 3060
aaactttgca taagcttgct aacctatttt attttttcca ctcacatacc agaaggggat 3120
atgatgttgt aatgacaaca agcctctctt cagatgttcc tgttggatat ttctcttggg 3180
ctgagtatga tatcatggct ccagtacaac ctaaaacaga gaatgcctta gcagccgctt 3240
tcatttctaa ttgtggtgct cgcaacttcc gcttgcaagc tttagaagcc cttgaaaggg 3300
caaatatcag aattgattct tatggcagtt gtcatcataa cagggatgga agaggttagt 3360
atatctcaat tatccaaact tactgaagga ttagaggata gaatatggat ggtgcatttt 3420
taagcagtgc cactagggag ctaattcttg tccatagagt agtattatgg atttgattga 3480
ctcttcctcg ggtgtcacac cttcctccag aagacaggat tctactacca gtgcaaacct 3540
tatttttttt ctcctggcta acgtgagcat gcatgtcgtt tttttagtga ttcgaattta 3600
tgctagtccg atgattgctt gtcaatggat tattttgctc tttttcttgt ttaaaatttg 3660
agtttcaatt atgccacctg ataagaataa agttggaata caacattcat ttaagtagtt 3720
cgatttcatt ctgaggaagt caggctgaaa tttgttggaa agagacgtat agtgagaaaa 3780
aatgttgtgg acaaatcatc tttctggatg ccgtgtatct tatacatgca attggtttag 3840
gtttgcacta atatccaatt gaattgtgtt acttgtcaat aaaaaatttc ctatcaaatc 3900
taacttctgg tctctgttct caatctgatg gcagttgaca aagtggaagc actgaagcgg 3960
tacaagttta gcttggcttt tgagaattct aatgaggagg actatgtaac tgaaaaattc 4020
tttcagtctc tggtagctgg taatcacatt tgttttttct tattgggttt gtagacttgg 4080
attttcagag ttgagagcat ctattatttt agctcagtcc ctcccttaac atgatagata 4140
catttgttcc tagttgtatt tgatgtggtt ttggttagat attctgtgtt tactagcaga 4200
ccttggaatt gtagtatcta aagcgtacaa ttatttgtag aagtttcagg aaggacaaaa 4260
ttctgagttc tgataaattc ttgatacatt caacaatgtt ttggatctag acttgcattt 4320
ctgtagaatg cacaatgtgc tctacactga gatggctcga atatttttgg aattttgttg 4380
agatgatttt gggggtatcg tcttagttga gcattttctt tatgctctaa gactaaattc 4440
tctttttcga ggtctatccc atgtttaaga ttttgacaat tttattagtt caggattgag 4500
atttaaggtt tcaatttgct gataaaagta agtctataaa acttgtagga tcaatccctg 4560
tggtggttgg tgctccaaac atccaagact ttgctccttc tcctaattca gttttacaca 4620
ttaaagagat aaaagatgct gaatcaattg ccaataccat gaagtacctt gctcaaaacc 4680
ctattgcata caatgagtca ttaaggtatg catcaataaa agttattgtt gttgttgttg 4740
ttgtcattgt tgttctccag ttgtttactt gataatggga tggtactctt cttaatagtt 4800
cgaattcctg tcgttgcaat tatacactgt ccaaatctct ctttttttaa agccatttgg 4860
tgccttttga aaatagtatt acaaagaaaa tattacatac ccatttcact aaaaggtttt 4920
cactactgta tttccagttt ttgaccaatt tatatataga tatttccttt tgatgttagg 4980
tggataactg aattgaacga gaacacaatg gatctctctc tgtttttctg tagttacaag 5040
acacttcttc cttacaagat ttacttaata tttcttaaat ttactggaca tctaacaaat 5100
gatttgcttt aattttcagg tggaagtttg agggcccatc tgatgccttc aaagccctgg 5160
ttgatatggc agcagttcat tcatcttgtc gtttgtgcat cttcttggca agtaggatcc 5220
gggaaagaga agagcagagt ccaaaattta tgaagcgtcc ctgcaaatgt actagaggga 5280
ctgaaactgt ctatcatgta tatgtacgtg aaagagggag gtttgagatg gattccattt 5340
tcttaaggta ttttcattct ccagttactg aattctgacc ttgaatgtct aagcaaattt 5400
tctctgactt gttaaaaaga atatcaaagc atattttctg aatatgttcg aggcagatat 5460
gcatctactt tttcctatca gttcaactgc ttttatatta ttattattat tattattcct 5520
ttcagcttcg tttgctgttg ttttgcactc aatcactcag tgaatgacaa tttttgagat 5580
atgttctcca gaattctacc agacaaagaa taatatttta gatttctata tcgtgaaatc 5640
ttctgtgctt ttcctttaat tcattgggga tggggtagac tctctctgtc cacatgtctg 5700
tggtcttgtc caagacactt gtaaagttat catctgctta tatctttctc tttccctctt 5760
accaagctgc gtgattattc tcatgttgaa gagctaaaag tagaacccga gagtttgcac 5820
cttctgctcg cccttccagt ctcctccatc tgtacaactg tgaggtcaaa tagttatgct 5880
tttttatcct acagattcca acaagtaaag ctgaaagtgg agctctcatt tacaatgaat 5940
gcatgtgaaa tacatgatat ctcgcaagag ttgatagtct aaggggttga aaagtgtttc 6000
aacatgaaaa gaggaaaaga gatttgtggt tggataacac catagagaca ctatcaatct 6060
gtgtataatc atttctgatt gattcgtagg ctgaagcagg aagatcctga aagttgttgt 6120
agtgggtagt tgcttctgaa tttctcggag taaagaaact aaagaaaagg aaattgaacc 6180
cttttcattt gaattttcga aaattcttcc atttttctat gggtacttcc tgcaccgcca 6240
ttatatcttt tgaattctgt cctggaattc tcctcctgtt agattgcaaa gcatcctctc 6300
ttttgtttaa tgttttcttg tcatagcttt ccttatcttt ctgatataaa ctttgaatca 6360
ccctaatttc tgtatctgtg cagatcgagt aatttgtctt taaaggcgtt tgaatctgct 6420
atcctctcga ggttcaagtc tgttaaacat gttcctgttt ggaaggagga aagacctcaa 6480
gtactacgcg gtgatgatga actcaaactt tacaaagtat atcctgttgg cttgacacag 6540
agacaagcag tgttttcctt cagattcaac ggggatactg agtttaagaa ttacattcaa 6600
agccacccat gtgcaaaatt tgaagccata ttcgtatag 6639
<210> 95
<211> 301
<212> PRT
<213> Artificial sequence
<220>
<223> rasburicase gene of Aspergillus
<400> 95
Ser Ala Val Lys Ala Ala Arg Tyr Gly Lys Asp Asn Val Arg Val Tyr
1 5 10 15
Lys Val His Lys Asp Glu Lys Thr Gly Val Gln Thr Val Tyr Glu Met
20 25 30
Thr Val Cys Val Leu Leu Glu Gly Glu Ile Glu Thr Ser Tyr Thr Lys
35 40 45
Ala Asp Asn Ser Val Ile Val Ala Thr Asp Ser Ile Lys Asn Thr Ile
50 55 60
Tyr Ile Thr Ala Lys Gln Asn Pro Val Thr Pro Pro Glu Leu Phe Gly
65 70 75 80
Ser Ile Leu Gly Thr His Phe Ile Glu Lys Tyr Asn His Ile His Ala
85 90 95
Ala His Val Asn Ile Val Cys His Arg Trp Thr Arg Met Asp Ile Asp
100 105 110
Gly Lys Pro His Pro His Ser Phe Ile Arg Asp Ser Glu Glu Lys Arg
115 120 125
Asn Val Gln Val Asp Val Val Glu Gly Lys Gly Ile Asp Ile Lys Ser
130 135 140
Ser Leu Ser Gly Leu Thr Val Leu Lys Ser Thr Asn Ser Gln Phe Trp
145 150 155 160
Gly Phe Leu Arg Asp Glu Tyr Thr Thr Leu Lys Glu Thr Trp Asp Arg
165 170 175
Ile Leu Ser Thr Asp Val Asp Ala Thr Trp Gln Trp Lys Asn Phe Ser
180 185 190
Gly Leu Gln Glu Val Arg Ser His Val Pro Lys Phe Asp Ala Thr Trp
195 200 205
Ala Thr Ala Arg Glu Val Thr Leu Lys Thr Phe Ala Glu Asp Asn Ser
210 215 220
Ala Ser Val Gln Ala Thr Met Tyr Lys Met Ala Glu Gln Ile Leu Ala
225 230 235 240
Arg Gln Gln Leu Ile Glu Thr Val Glu Tyr Ser Leu Pro Asn Lys His
245 250 255
Tyr Phe Glu Ile Asp Leu Ser Trp His Lys Gly Leu Gln Asn Thr Gly
260 265 270
Lys Asn Ala Glu Val Phe Ala Pro Gln Ser Asp Pro Asn Gly Leu Ile
275 280 285
Lys Cys Thr Val Gly Arg Ser Ser Leu Lys Ser Lys Leu
290 295 300

Claims (37)

1.一种悬浮的分离的植物细胞，其在所述植物细胞中包含选自由DCL2、DCL4、RDR1、RDR2和RDR6所组成的组中的至少两个基因的所有等位基因的功能缺失性突变。
2.根据权利要求1所述的分离的植物细胞，其中，所述DCL2中的所述功能缺失性突变位于所述植物细胞中由所述DCL2的所有等位基因共有的区域中。
3.根据权利要求1至2中任一项所述的分离的植物细胞，其中，所述DCL2中的所述功能缺失性突变位于对应于SEQ ID NO:74的核酸残基288-307和/或881-900内；和/或对应于SEQ ID NO:75的核酸残基288-307和/或881-900内。
4.根据权利要求2至3中任一项所述的分离的植物细胞，其中，所述DCL2基因的所有等位基因共有的所述区域包含选自由SEQ ID NO:1-2所组成的组的序列。
5.根据权利要求1至4中任一项所述的分离的植物细胞，其中，所述DCL4中的所述功能缺失性突变位于所述植物细胞中的所述DCL4的所有等位基因共有的区域中。
6.根据权利要求1至5中任一项所述的分离的植物细胞，其中，所述DCL4中的所述功能缺失性突变位于对应于SEQ ID NO:76的核酸残基967-986和/或1407-1426内；和/或对应于SEQ ID NO:77的核酸残基931-950和/或1371-1390内。
7.根据权利要求5至6中任一项所述的分离的植物细胞，其中，所述DCL4基因的所有等位基因共有的所述区域包含选自由SEQ ID NO:3-4所组成的组的序列。
8.根据权利要求1至7中任一项所述的分离的植物细胞，其中，所述RDR1中的所述功能缺失性突变位于所述植物细胞中所述RDR1的所有等位基因共有的区域中。
9.根据权利要求1至8中任一项所述的分离的植物细胞，其中，所述RDR1中的所述功能缺失性突变位于对应于SEQ ID NO:78的核酸残基916-937和/或962-984内；和/或对应于SEQ ID NO:79的核酸残基921-937和/或962-984内。
10.根据权利要求8至9中任一项所述的分离的植物细胞，其中，所述RDR1基因的所有等位基因共有的所述区域包含选自由SEQ ID NO:26-27所组成的组的序列。
11.根据权利要求1至10中任一项所述的分离的植物细胞，其中，所述RDR2中的所述功能缺失性突变位于所述植物细胞中所述RDR2的所有等位基因共有的区域中。
12.根据权利要求1至11中任一项所述的分离的植物细胞，其中，所述RDR2中的所述功能缺失性突变位于对应于SEQ ID NO:80的核酸残基575-553和/或589-612内；和/或对应于SEQ ID NO:81的核酸残基575-553和/或589-612内。
13.根据权利要求11至12中任一项所述的分离的植物细胞，其中，所述RDR2基因的所有等位基因共有的所述区域包含选自SEQ ID NO:28-29的序列。
14.根据权利要求1至13中任一项所述的分离的植物细胞，其中，所述RDR6中的所述功能缺失性突变位于所述植物细胞中所述RDR6的所有等位基因共有的区域中。
15.根据权利要求1至14中任一项所述的分离的植物细胞，其中，所述RDR6中的所述功能缺失性突变位于对应于SEQ ID NO:82的核酸残基2767-2785和/或2820-2839内；对应于SEQ ID NO:83的核酸残基49-67和/或102-121；和/或对应于SEQ ID NO:84的核酸残基49-67和/或102-121内。
16.根据权利要求14至15中任一项所述的分离的植物细胞，其中，所述RDR6基因的所有等位基因共有的所述区域包含选自由SEQ ID NO:30-31所组成的组的序列。
17.根据权利要求1至16中任一项所述的分离的植物细胞，其中，与具有相同遗传背景但未用下调所述糖基化酶表达和/或活性的试剂的对照植物细胞相比，所述植物细胞具有降低的糖基化酶表达和/或活性。
18.根据权利要求1至17中任一项所述的分离的植物细胞，包含用于表达目标表达产物的异源核酸序列。
19.一种在植物细胞中表达目标重组表达产物的方法，所述方法包括在允许所述目标表达产物表达的条件下培养权利要求18所述的细胞。
20.一种消除选自植物细胞中由DCL2、DCL4、RDR1、RDR2和RDR6所组成的组中的至少两个基因的表达和/或活性的方法，所述方法包括向悬浮的分离的植物细胞中引入一种试剂，所述试剂能够在选自所述植物细胞中由DCL2、DCL4、RDR1、RDR2和RDR6所组成的组中的至少两种基因的所有等位基因中引入功能缺失性突变。
21.根据权利要求20所述的方法，其中，所述方法包括向所述分离的植物细胞中引入能够下调糖基化酶的表达和/或活性的试剂。
22.根据权利要求20所述的方法，其中，与具有相同遗传背景但未用下调所述糖基化酶表达和/或活性的试剂的对照植物细胞相比，所述植物细胞具有降低的糖基化酶表达和/或活性。
23.根据权利要求17至19和21至22中任一项所述的分离的植物细胞或方法，其中，所述糖基化酶包括木糖基转移酶和/或岩藻糖基转移酶。
24.根据权利要求20至23中任一项所述的方法，其中，所述试剂是基因组编辑试剂。
25.根据权利要求24所述的方法，其中，所述基因组编辑试剂选自由CRISPR/Cas系统、锌指核酸酶(ZFN)、转录激活因子样效应物核酸酶(TALEN)或巨核酸技术所组成的组。
26.根据权利要求20至25中任一项所述的方法，其中，所述试剂包含DCL2 DNA靶向序列，所述DCL2 DNA靶向序列包含选自由SEQ ID NO:1-2所组成的组的核酸序列。
27.根据权利要求20至26中任一项所述的方法，其中，所述试剂包含DCL4 DNA靶向序列，所述DCL4 DNA靶向序列包含选自由SEQ ID NO:3-4所组成的组的核酸序列。
28.根据权利要求20至27中任一项所述的方法，其中，所述试剂包含RDR1 DNA靶向序列，所述RDR1 DNA靶向序列包含选自由SEQ ID NO:26-27所组成的组的核酸序列。
29.根据权利要求20至28中任一项所述的方法，其中，所述试剂包含RDR2 DNA靶向序列，所述RDR2 DNA靶向序列包含选自由SEQ ID NO:28-29所组成的组的核酸序列。
30.根据权利要求20至29中任一项所述的方法，其中，所述试剂包含RDR6 DNA靶向序列，所述RDR6 DNA靶向序列包含选自由SEQ ID NO:30-31所组成的组的核酸序列。
31.根据权利要求20至30中任一项所述的方法，还包括在所述分离的植物细胞中表达除所述试剂以外的目标重组表达产物。
32.根据权利要求1至31中任一项所述的分离的植物细胞和方法，其中，通过RT-PCR测定，所述功能缺失性突变消除所述至少两种基因的表达。
33.根据权利要求1至31中任一项所述的分离的植物细胞和方法，其中，所述功能缺失性突变消除所述DCL2和DCL4的表达和/或活性，这是通过所述转基因在所述植物细胞中表达后，转基因特异性21-nt和22-nt siRNAs在所述植物细胞中不表达来确定的。
34.根据权利要求1至33中任一项所述的分离的植物细胞或方法，其中，所述植物选自由烟草、拟南芥、芦荟、葡萄籽、油棕、车前草、松树、香蕉、大枣、茄子、荷荷巴、菠萝、橡胶树、木薯、山药、甘薯和番茄所组成的组。
35.根据权利要求1至33中任一项所述的分离的植物细胞或方法，其中，所述植物是烟草植物。
36.根据权利要求34至35中任一项所述的分离的植物细胞或方法，其中，所述烟草是烟叶。
37.根据权利要求1至33中任一项所述的分离的植物细胞或方法，其中，所述植物细胞是BY-2系细胞。
CN202180081013.4A 2020-10-05 2021-10-05 切酶样敲除植物细胞 Pending CN116648513A (zh)

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