CN116616290A - Low-residue hydrogen peroxide disinfectant and preparation method thereof - Google Patents
Low-residue hydrogen peroxide disinfectant and preparation method thereof Download PDFInfo
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- CN116616290A CN116616290A CN202310374754.2A CN202310374754A CN116616290A CN 116616290 A CN116616290 A CN 116616290A CN 202310374754 A CN202310374754 A CN 202310374754A CN 116616290 A CN116616290 A CN 116616290A
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- hydrogen peroxide
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title claims abstract description 145
- 239000000645 desinfectant Substances 0.000 title claims abstract description 70
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims abstract description 36
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000019253 formic acid Nutrition 0.000 claims abstract description 14
- 239000004094 surface-active agent Substances 0.000 claims abstract description 13
- 239000008213 purified water Substances 0.000 claims abstract description 11
- NECRQCBKTGZNMH-UHFFFAOYSA-N 3,5-dimethylhex-1-yn-3-ol Chemical compound CC(C)CC(C)(O)C#C NECRQCBKTGZNMH-UHFFFAOYSA-N 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- AOOVIJCEQRHGNY-UHFFFAOYSA-N 3-methylpent-1-yn-1-ol Chemical compound CCC(C)C#CO AOOVIJCEQRHGNY-UHFFFAOYSA-N 0.000 claims description 4
- 229940051841 polyoxyethylene ether Drugs 0.000 claims description 4
- 229920000056 polyoxyethylene ether Polymers 0.000 claims description 4
- IHJUECRFYCQBMW-UHFFFAOYSA-N 2,5-dimethylhex-3-yne-2,5-diol Chemical compound CC(C)(O)C#CC(C)(C)O IHJUECRFYCQBMW-UHFFFAOYSA-N 0.000 claims description 3
- JQZGUQIEPRIDMR-UHFFFAOYSA-N 3-methylbut-1-yn-1-ol Chemical compound CC(C)C#CO JQZGUQIEPRIDMR-UHFFFAOYSA-N 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 238000000034 method Methods 0.000 claims 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 26
- 230000000694 effects Effects 0.000 abstract description 12
- 210000004666 bacterial spore Anatomy 0.000 abstract description 9
- 230000000249 desinfective effect Effects 0.000 abstract description 4
- 230000007613 environmental effect Effects 0.000 abstract description 4
- 238000012545 processing Methods 0.000 abstract description 3
- 239000007921 spray Substances 0.000 abstract description 3
- 238000005507 spraying Methods 0.000 abstract description 3
- 239000007788 liquid Substances 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 13
- 230000001954 sterilising effect Effects 0.000 description 8
- 239000005708 Sodium hypochlorite Substances 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 4
- 102000016938 Catalase Human genes 0.000 description 3
- 108010053835 Catalase Proteins 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 239000000460 chlorine Substances 0.000 description 3
- 229910052801 chlorine Inorganic materials 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000002147 killing effect Effects 0.000 description 3
- 244000000010 microbial pathogen Species 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- SCKXCAADGDQQCS-UHFFFAOYSA-N Performic acid Chemical compound OOC=O SCKXCAADGDQQCS-UHFFFAOYSA-N 0.000 description 2
- 150000001299 aldehydes Chemical class 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- -1 silver ions Chemical class 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- FVTRDWMTAVVDCU-UHFFFAOYSA-N acetic acid;hydrogen peroxide Chemical compound OO.CC(O)=O FVTRDWMTAVVDCU-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- VUZPPFZMUPKLLV-UHFFFAOYSA-N methane;hydrate Chemical compound C.O VUZPPFZMUPKLLV-UHFFFAOYSA-N 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000012747 synergistic agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/16—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/30—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests characterised by the surfactants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P1/00—Disinfectants; Antimicrobial compounds or mixtures thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
The application discloses a low-residue hydrogen peroxide disinfectant, which consists of the following components in percentage by weight: hydrogen peroxide 2.0-8.0%; 0.1-1% of formic acid; acetic acid 0.5-5%; 0.05-0.5% of alkynol surfactant; the balance being purified water. When the hydrogen peroxide disinfectant is used for disinfecting the surfaces of environmental objects, bacterial spores can be killed, and the high-level disinfection effect can be achieved after the hydrogen peroxide disinfectant is acted for 5 minutes; when the spray is used for air disinfection, the disinfection effect can be achieved after 5 minutes of action after the spraying is finished; the prepared liquid has little residue and does not need to be cleaned again after use. The hydrogen peroxide disinfectant can be used for disinfecting the environment, equipment and facility surfaces and air of medical and health institutions, public places, food processing places and other places with clean requirements. In addition, the application also discloses a preparation method of the hydrogen peroxide disinfectant.
Description
Technical Field
The application relates to the technical field of chemical disinfection of clean environment surfaces and air, in particular to a low-residue hydrogen peroxide disinfectant capable of rapidly killing bacterial spores and a preparation method thereof.
Background
The chemical disinfectants used for disinfecting the surfaces of the environment at present mainly comprise alcohol disinfectants, chlorine-containing disinfectants, quaternary ammonium salts disinfectants, hydrogen peroxide disinfectants and the like. The chlorine-containing disinfectant has strong effect, but has large chlorine smell, strong corrosiveness and more residues; the quaternary ammonium salt disinfectant has high safety, but can only achieve low-level disinfection and has a large amount of residues; the ethanol disinfectant can achieve medium-level disinfection and has no residue, but is inflammable and explosive and has high volatilization speed, higher concentration and enough action time are required to be achieved, and the disinfection is often failed because the required action time is not achieved; the final hydrogen peroxide disinfectant has the main component of hydrogen peroxide which is safe and residue-free, and the product is only water and oxygen, so that the final hydrogen peroxide disinfectant is a very ideal disinfectant.
However, due to the existence of catalysts in the general bacteria-dyeing environment, the conventional low-concentration hydrogen peroxide disinfectant has poor anti-interference capability, generally unsatisfactory effect, very limited effect on bacterial spores and only low-medium level disinfection. In order to improve the sterilization effect, the concentration of hydrogen peroxide is generally increased, so medical hydrogen peroxide generally contains 3% hydrogen peroxide, and the hydrogen peroxide at the concentration has strong oxidizing property and has certain potential danger in terms of safety. In addition, other synergistic substances, such as metal ions, e.g., silver ions, are generally added to improve the disinfection effect of hydrogen peroxide, which may cause instability of the hydrogen peroxide solution, and stabilizers, such as citric acid, phosphate, etc., are added to improve the stability of hydrogen peroxide, resulting in complex formulation and high cost. In addition, although hydrogen peroxide itself does not remain, these synergists and stabilizers added remain on the surface of the object, which affects the subsequent use safety of the sterilized article (especially the article with cleaning requirements).
In addition, with the development of society in recent years, the medium-low level disinfectant which can not kill bacterial spores can not meet the requirement of environmental object surface disinfection in areas with high infection risk, and the disinfectant which can kill bacterial spores at present mainly comprises sodium hypochlorite disinfectant and aldehyde disinfectant, wherein the sodium hypochlorite disinfectant has very strong corrosiveness on a plurality of metals such as non-stainless steel due to the strong alkali and strong oxidization characteristics of the sodium hypochlorite disinfectant, so that the application range of the disinfectant is limited; glutaraldehyde disinfectants are also not suitable for disinfection as an environmental surface due to their strong skin mucosa irritation and allergic reaction. Meanwhile, the residual quantity of a plurality of disinfectants in various places such as medical and health institutions, food processing places, medicine production workshops and the like has high requirements, and sodium hypochlorite and aldehyde disinfectants have larger residues, so that the use range and convenience of the disinfectant are restricted.
In view of the above drawbacks, there is a need in such a scenario for a disinfectant product with low residue that can quickly kill bacterial spores.
Disclosure of Invention
Aiming at the defects of the prior art, the application provides a low-residue hydrogen peroxide disinfectant and a preparation method thereof. The application can quickly kill bacterial spores with low residue and has good stability. In addition, the application also provides a preparation method of the low-residue hydrogen peroxide disinfectant.
The application provides a hydrogen peroxide disinfectant, which consists of the following components in percentage by weight:
hydrogen peroxide 2.0-8.0%;
0.1-1% of formic acid;
acetic acid 0.5-5%;
0.05-0.5% of alkynol surfactant;
the balance being purified water.
Further, in the hydrogen peroxide disinfectant, the raw material concentration of the hydrogen peroxide can be different concentrations of 30%, 35% and the like, and the final concentration reaches the pure hydrogen peroxide concentration of the application.
Further, in the hydrogen peroxide disinfectant, the alkynol surfactant is preferably one or a mixture of several of methylbutynol, methylpentanynol, 3, 5-dimethyl-1-hexyne-3-ol, 2, 5-dimethyl-3-hexyne-2, 5-diol, and 2,4,7, 9-tetramethyl-5-sunflower alkyne-4, 7-diol polyoxyethylene ether.
The application provides a preparation method of a hydrogen peroxide disinfectant, which comprises the following steps: adding purified water, formic acid, acetic acid, alkynol surfactant and hydrogen peroxide in weight percentage into a batching container in turn, and stirring uniformly to prepare the hydrogen peroxide disinfectant.
Compared with the prior art, the application has the following advantages: the formic acid and acetic acid adopted in the application are compounded to serve as a synergistic agent. As most common pathogenic microorganisms metabolize to produce catalase, so that the catalase can be prevented from being attacked by oxygen free radicals generated by hydrogen peroxide to resist a disinfectant, and the existing tests prove that the catalase cannot act on peroxycarboxylic acid, so that the peroxycarboxylic acid can carry the oxygen free radicals into pathogenic microorganisms to generate a killing effect. In the research, we have unexpectedly found that the addition of formic acid to a hydrogen peroxide-acetic acid system results in the rapid formation of peroxycarboxylic acids which have a very strong penetrating effect, so that the sterilizing effect of hydrogen peroxide is significantly improved in the presence of formic acid. At the end of the disinfectant action, formic acid is oxidized and decomposed into carbon dioxide and water, meanwhile, hydrogen peroxide is decomposed into oxygen and water, and acetic acid is volatile, so that the system can be sterilized without residues.
The application also particularly adds the alkynol surfactant with volatility, and the surfactant has rapid infiltration and dispersion effects, and can help the disinfection factors to reach the tiny pits on the surface of the object, so that the disinfectant can contact pathogenic microorganisms at dead angles, thereby achieving the disinfection effect without dead angles comprehensively. Meanwhile, the surfactant has a certain volatilization function at normal temperature, can volatilize into air when sprayed or wiped on the surface of an object, and is discharged out of the environment along with an airflow system, so that no residue is left after disinfection. The hydrogen peroxide disinfectant can kill bacterial spores. Microorganism tests show that the hydrogen peroxide disinfectant with the concentration of 2% -8% acts for 5 minutes to achieve high-level disinfection;
the hydrogen peroxide disinfectant can be used for air disinfection, and is sprayed for 10min with the dosage of 5mL/m 3 After spraying is finished, the composition acts for 5 minutes, and the killing logarithmic value of the staphylococcus albus is more than 4.00.
The hydrogen peroxide disinfectant is stored for 180 days at 40 ℃, the drop rate is less than 2%, the stability is good, and the hydrogen peroxide disinfectant can be stably stored for more than 36 months at normal temperature.
Detailed Description
The application provides a hydrogen peroxide disinfectant, which consists of the following components in percentage by weight:
hydrogen peroxide 2.0-8.0%;
0.1-1% of formic acid;
acetic acid 0.5-5%;
0.05-0.5% of alkynol surfactant;
the balance being purified water.
Further, in the hydrogen peroxide disinfectant, the raw material concentration of the hydrogen peroxide may be different concentrations such as 30% and 35%, and the final concentration is the pure hydrogen peroxide concentration.
Further, in the hydrogen peroxide disinfectant, the alkynol surfactant is preferably one or a mixture of several of methylbutynol, methylpentanynol, 3, 5-dimethyl-1-hexyne-3-ol, 2, 5-dimethyl-3-hexyne-2, 5-diol, and 2,4,7, 9-tetramethyl-5-sunflower alkyne-4, 7-diol polyoxyethylene ether.
In the application, the purified water is prepared according to the requirements of Chinese pharmacopoeia.
The application provides a preparation method of a hydrogen peroxide disinfectant, which comprises the following steps: and sequentially adding the purified water, formic acid, acetic acid, alkynol surfactant and hydrogen peroxide in percentage by weight into a batching container, and uniformly stirring to prepare the hydrogen peroxide disinfectant.
The application will be further illustrated with reference to specific examples. These examples should be construed as merely illustrative of the present application and not limiting the scope of the present application. Various changes and modifications to the present application may be made by one skilled in the art after reading the description herein, and such equivalent changes and modifications are intended to fall within the scope of the present application as defined in the appended claims.
Example 1
86.3kg of purified water, 0.7kg of formic acid, 4.0kg of acetic acid, 0.1kg of methylbutinol, 0.3kg of 3, 5-dimethyl-1-hexyne-3-ol and 8.6kg of 35% hydrogen peroxide are sequentially added into a batching container and stirred uniformly to prepare a sample of the hydrogen peroxide disinfectant example 1.
Example 2
84.5kg of purified water, 0.2kg of formic acid, 3.0kg of acetic acid, 0.2kg of methylpentanynol, 0.3kg of 3, 5-dimethyl-1-hexyne-3-ol and 11.8kg of 35% hydrogen peroxide are sequentially added into a batching container and uniformly stirred to prepare a sample of the hydrogen peroxide disinfectant example 2.
Example 3
81kg of purified water, 0.1kg of formic acid, 1.0kg of acetic acid, 0.4kg of 2,4,7, 9-tetramethyl-5-sunflower-alkyne-4, 7-diol polyoxyethylene ether and 17.5kg of 30% hydrogen peroxide are sequentially added into a batching container, and uniformly stirred to prepare a sample of the hydrogen peroxide disinfectant example 3.
Test example 1-Low residual high level Hydrogen peroxide disinfectant non-volatile assay
In a 100mL evaporation pan, about 50g of the sample of the example was weighed to the nearest 0.01g, placed on a water bath to evaporate and dry, then the residue was dried in an oven at 105-110 ℃ to a measure, placed in a dryer to cool, accurately weighed, and the nonvolatile ratio was measured. The results are shown in Table 1:
TABLE 1 Low residual Hydrogen peroxide disinfectant non-volatile test data
；
Conclusion: the hydrogen peroxide disinfectant prepared in the embodiments 1-3 of the application has extremely low residues, and the proportion of non-volatile residues is less than one ten thousandth, thus basically meeting the cleaning requirement.
Test example 2-Low residual high level Hydrogen peroxide disinfectant sterilizing Capacity test
Sterilization tests were performed according to the relevant regulations of the "sterilization technical Specification" (2002 edition), and the test results are shown in Table 2:
TABLE 2 Sterilization capability test of low residual Hydrogen peroxide disinfectants
；
Conclusion: the hydrogen peroxide disinfectant prepared in the embodiments 1-3 of the application can achieve high-level disinfection after 5 minutes of action, and can achieve the air disinfection effect after 5 minutes of action after the air spray disinfection according to the specified dosage is finished.
Test example 3-accelerated stability test of Hydrogen peroxide disinfectant
The test was carried out according to GB/T38499-2020 disinfectant stability evaluation method, and the test results are shown in Table 3:
TABLE 3 accelerated stability test data for Hydrogen peroxide disinfectants (in terms of Hydrogen peroxide)
；
Conclusion: the hydrogen peroxide disinfectant prepared in the examples 1-3 of the application is stored for 180 days at 40 ℃, the drop rate is less than 2%, and the stability is good, which shows that the effective period can reach 36 months.
The test proves that the hydrogen peroxide disinfectant can kill bacterial spores when being used for disinfecting the surfaces of environmental objects, and can achieve high-level disinfection effect after being acted for 5 minutes; when the spray is used for air disinfection, the disinfection effect can be achieved after 5 minutes of action after the spraying is finished; the prepared liquid has good stability and the effective period can reach more than 36 months. The air sterilizer can be used for sterilizing the environment, equipment and facility surfaces and air of medical and health institutions, public places, food processing places and other places with high risk of infection, and is particularly suitable for sterilizing the environment object surfaces and air with clean requirements.
Claims (3)
1. The low-residue hydrogen peroxide disinfectant and the preparation method thereof are characterized by comprising the following components in percentage by weight:
hydrogen peroxide 2.0-8.0%;
0.1-1% of formic acid;
acetic acid 0.5-5%;
0.05-0.5% of alkynol surfactant;
the balance being purified water.
2. The low-residue hydrogen peroxide disinfectant and the preparation method thereof according to claim 1, wherein the alkynol surfactant is one or a mixture of several of methylbutynol, methylpentanynol, 3, 5-dimethyl-1-hexyne-3-ol, 2, 5-dimethyl-3-hexyne-2, 5-diol, 2,4,7, 9-tetramethyl-5-hexyne-4, 7-diol polyoxyethylene ether.
3. A method of preparing the low residual hydrogen peroxide disinfectant and method of preparing the same as claimed in claims 1-2, comprising the steps of:
adding purified water, formic acid, acetic acid, alkynol surfactant and hydrogen peroxide in weight percentage into a batching container in turn, and stirring uniformly to prepare the hydrogen peroxide disinfectant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310374754.2A CN116616290A (en) | 2023-04-10 | 2023-04-10 | Low-residue hydrogen peroxide disinfectant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310374754.2A CN116616290A (en) | 2023-04-10 | 2023-04-10 | Low-residue hydrogen peroxide disinfectant and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN116616290A true CN116616290A (en) | 2023-08-22 |
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|---|---|---|---|
| CN202310374754.2A Pending CN116616290A (en) | 2023-04-10 | 2023-04-10 | Low-residue hydrogen peroxide disinfectant and preparation method thereof |
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| Country | Link |
|---|---|
| CN (1) | CN116616290A (en) |
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2023
- 2023-04-10 CN CN202310374754.2A patent/CN116616290A/en active Pending
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