CN116602880A - Skin-friendly stable microemulsion and preparation process and application thereof - Google Patents
Skin-friendly stable microemulsion and preparation process and application thereof Download PDFInfo
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- CN116602880A CN116602880A CN202310630093.5A CN202310630093A CN116602880A CN 116602880 A CN116602880 A CN 116602880A CN 202310630093 A CN202310630093 A CN 202310630093A CN 116602880 A CN116602880 A CN 116602880A
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- 239000004530 micro-emulsion Substances 0.000 title claims abstract description 73
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 24
- 239000002904 solvent Substances 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- -1 polyethylene Polymers 0.000 claims abstract description 14
- 239000004698 Polyethylene Substances 0.000 claims abstract description 11
- PDYOTPOJFZAOIS-UHFFFAOYSA-N decanoic acid;2,2-dimethylpropane-1,3-diol;octanoic acid Chemical compound OCC(C)(C)CO.CCCCCCCC(O)=O.CCCCCCCCCC(O)=O PDYOTPOJFZAOIS-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 11
- 229920000573 polyethylene Polymers 0.000 claims abstract description 11
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims abstract description 9
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims abstract description 8
- 229920001213 Polysorbate 20 Polymers 0.000 claims abstract description 8
- 229940055577 oleyl alcohol Drugs 0.000 claims abstract description 8
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229920001748 polybutylene Polymers 0.000 claims abstract description 8
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims abstract description 8
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims abstract description 8
- 229940068977 polysorbate 20 Drugs 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims description 52
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 235000011187 glycerol Nutrition 0.000 claims description 8
- 239000004359 castor oil Substances 0.000 claims description 7
- 235000019438 castor oil Nutrition 0.000 claims description 7
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 7
- 239000003921 oil Substances 0.000 claims description 7
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 6
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 6
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 6
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 3
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 3
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims description 3
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 3
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 3
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 3
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 claims description 3
- 229960005323 phenoxyethanol Drugs 0.000 claims description 3
- 229920000642 polymer Polymers 0.000 claims description 3
- 239000003755 preservative agent Substances 0.000 claims description 3
- 230000002335 preservative effect Effects 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- 229940104261 taurate Drugs 0.000 claims description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000007788 liquid Substances 0.000 abstract description 5
- 239000002537 cosmetic Substances 0.000 abstract description 3
- 230000003020 moisturizing effect Effects 0.000 abstract description 2
- 239000000203 mixture Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- GHJOIQFPDMIKHT-UHFFFAOYSA-N propane-1,2,3-triol;prop-2-enoic acid Chemical compound OC(=O)C=C.OCC(O)CO GHJOIQFPDMIKHT-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/068—Microemulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a skin-friendly stable microemulsion, and a preparation process and application thereof, wherein the microemulsion consists of oleyl alcohol polyether-5, polysorbate-20, a solubilizer, PEG/PPG/polybutylene glycol-8/5/3 glycerol, neopentyl glycol dicaprylate/dicaprate, propylene glycol, butanediol, polyethylene glycol-8 and water; the microemulsion adopts neopentyl glycol dicaprylate/dicaprate as an oil phase, is matched with four emulsifying agents, has stable thermodynamics, and has relatively smaller using amount of the emulsifying agents and better stability after a long time compared with most microemulsion liquids; the microemulsion can be used for preparing toner and other cosmetics, and forms an oil film on skin after use, so that the microemulsion can be used for moisturizing for a long time, and compared with the existing toner, the microemulsion has softer and finer skin feel and is skin-friendly and comfortable.
Description
Technical Field
The invention relates to a skin-friendly stable microemulsion, and a preparation process and application thereof, and belongs to the technical field of cosmetics.
Background
Microemulsions are dispersions in which two immiscible liquids are dispersed into small particles in one liquid on the other with the aid of a surfactant. The solubilizer is a transparent and thermodynamically stable equilibrium system with the grain diameter of 5-20 nm, and the proportion of the disperse phase is smaller. The microemulsion has higher disperse phase proportion and the grain diameter is 20 nm-100 nm. Compared with other solubilizers, the existing microemulsion in the market at present has the disadvantages of large dosage of emulsifier, higher cost, insufficient stability and easy layering after one year of storage; and the skin feel is still to be improved.
Disclosure of Invention
Aiming at the technical problems, the invention aims at: provides a skin-friendly stable microemulsion, and a preparation process and application thereof.
The technical solution of the invention is realized as follows: a skin-friendly stable microemulsion is composed of 7% -9% of oleyl alcohol polyether-5, 3% -5% of polysorbate-20, 3.3% -5.3% of solubilizer, 1% -1.6% of PEG/PPG/polybutylene glycol-8/5/3 glycerol, 3.5% -4.5% of neopentyl glycol dicaprylate/dicaprate, 12% -14% of propylene glycol, 3.3% -5.3% of butanediol, 2.4% -3.2% of polyethylene glycol-8 and 52.1% -64.5% of water.
Preferably, the solubilizer is one or more of coco polyether-7, PPG-1-PEG-9 month Gui Erchun ether and PEG-40 hydrogenated castor oil.
The invention also provides a preparation process of the skin-friendly stable microemulsion, which comprises the following steps:
(1) mixing the microemulsion A phase, stirring for 4-8 minutes at normal temperature to a transparent state, wherein the stirring speed is 150-250rpm;
the microemulsion A phase is an emulsifier phase, and the emulsifier phase comprises 7% -9% of oleyl alcohol polyether-5, 3% -5% of polysorbate-20, 3.3% -5.3% of solubilizer, and 1% -1.6% of PEG/PPG/polybutylene glycol-8/5/3 glycerol;
(2) adding the phase B of the microemulsion, stirring for 8-15 minutes at normal temperature to a transparent state, wherein the stirring speed is 600-1000rpm;
the microemulsion B phase is an oil phase, and the oil phase is 3.5% -4.5% of neopentyl glycol dicaprylate/dicaprate;
(3) adding the microemulsion C phase, stirring at normal temperature for 8-15 min to transparent state, and stirring at 600-1000rpm;
the microemulsion C phase is a solvent phase, and the solvent phase comprises 12% -14% of propylene glycol, 3.3% -5.3% of butanediol and 2.4% -3.2% of polyethylene glycol-8;
(4) adding the D phase of the microemulsion, stirring for 4-8 minutes at normal temperature to a transparent state, wherein the stirring speed is 250-350rpm;
the microemulsion D phase is water phase, and the water phase is 52.1% -64.5% of water.
Preferably, the solubilizer is one or more of coco polyether-7, PPG-1-PEG-9 month Gui Erchun ether and PEG-40 hydrogenated castor oil.
The skin-friendly stable microemulsion can be applied to toner, and according to the application, the microemulsion toner is provided, and consists of 96.1-97.1% of toner A phase, 2-2.4% of toner B phase, 0.1-0.3% of toner C phase and 0.8-1.2% of toner D phase; the toner A phase is water phase, the toner B phase is microemulsion phase, the toner C phase is polymer phase, and the toner D phase is preservative phase.
Preferably, the toner A phase consists of water, citric acid, sodium citrate, EDTA disodium, trehalose, sodium hyaluronate, nano sodium hyaluronate, 1, 2-pentanediol, butanediol, propylene glycol, hydrated gel and polyethylene glycol-8.
Preferably, the toner B phase consists of oleyl alcohol polyether-5, polysorbate-20, a solubilizer, PEG/PPG/polybutylene glycol-8/5/3 glycerol, neopentyl glycol dicaprylate/dicaprate, propylene glycol, butylene glycol, polyethylene glycol-8 and water; the solubilizer is one or more of coco polyether-7, PPG-1-PEG-9 month Gui Erchun ether and PEG-40 hydrogenated castor oil.
Preferably, the toner C phase is poly (acryl dimethyl taurate) sodium, and the toner D phase is composed of 1, 2-hexanediol, ethylhexyl glycerol and phenoxyethanol.
The invention also provides a preparation process of the microemulsion toner, which comprises the following steps:
(1) mixing the toner A, stirring for 8-15 minutes to transparent state, wherein the stirring temperature is 60-70 ℃ and the stirring speed is 250-350rpm;
(2) adding the toner B phase, stirring for 4-8 minutes at 40-50 ℃ and at 400-600rpm;
(3) adding the toner C phase, stirring for 8-15 minutes at 40-50 ℃ and at 600-1000rpm;
(4) adding the toner D phase, stirring for 2-3 min at 30-40deg.C and stirring speed of 400-600rpm.
Due to the application of the technical scheme, compared with the prior art, the invention has the following advantages:
the invention provides a skin-friendly stable microemulsion, which adopts neopentyl glycol dicaprylate/dicaprate as an oil phase and is matched with four emulsifying agents, the thermodynamics of the microemulsion is stable, and compared with most microemulsion liquids, the use amount of the emulsifying agents is relatively small, and the stability after a long time is also good; the microemulsion can be used for preparing toner and other cosmetics, and forms an oil film on skin after use, so that the microemulsion can be used for moisturizing for a long time, and compared with the existing toner, the microemulsion has softer and finer skin feel and is skin-friendly and comfortable.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following description will briefly explain the drawings needed in the description of the embodiments of the present invention, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to the contents of the embodiments of the present invention and these drawings without inventive effort for those skilled in the art.
FIG. 1 is a process flow diagram of a skin-friendly stable microemulsion according to the present invention;
fig. 2 is a process flow diagram of the microemulsion toner of the present invention.
Detailed Description
In order to make the technical problems solved by the present invention, the technical solutions adopted and the technical effects achieved more clear, the technical solutions of the embodiments of the present invention will be described in further detail below with reference to the accompanying drawings, and it is obvious that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to fall within the scope of the invention.
The skin-friendly stable microemulsion consists of 7% -9% of oleyl alcohol polyether-5, 3% -5% of polysorbate-20, 3.3% -5.3% of solubilizer, 1% -1.6% of PEG/PPG/polybutylene glycol-8/5/3 glycerol, 3.5% -4.5% of neopentyl glycol dicaprylate/dicaprate, 12% -14% of propylene glycol, 3.3% -5.3% of butanediol, 2.4% -3.2% of polyethylene glycol-8 and 52.1% -64.5% of water.
Wherein the solubilizer is one or more of coco polyether-7, PPG-1-PEG-9 month Gui Erchun ether and PEG-40 hydrogenated castor oil.
Examples 1-3 of the microemulsion are shown in the following table:
TABLE 1 microemulsion composition proportion Table
The scheme also provides a preparation process of the skin-friendly stable microemulsion, which comprises the following steps:
(1) mixing the microemulsion A phase, stirring for 4-8 minutes at normal temperature to a transparent state, wherein the stirring speed is 150-250rpm; the stirring time is preferably 5 minutes and the speed is preferably 200rpm.
(2) Adding the phase B of the microemulsion, stirring for 8-15 minutes at normal temperature to a transparent state, wherein the stirring speed is 600-1000rpm; the stirring time is preferably 10 minutes and the speed is preferably 800rpm.
(3) Adding the microemulsion C phase, stirring at normal temperature for 8-15 min to transparent state, and stirring at 600-1000rpm; the stirring time is preferably 10 minutes and the speed is preferably 800rpm.
(4) Adding the D phase of the microemulsion, stirring for 4-8 minutes at normal temperature to a transparent state, wherein the stirring speed is 250-350rpm; the stirring time is preferably 5 minutes and the speed is preferably 300rpm.
Finally, the skin-friendly stable microemulsion is obtained.
The microemulsion adopts neopentyl glycol dicaprylate/dicaprate as an oil phase and is matched with four emulsifying agents, so that the microemulsion is thermodynamically stable, and compared with most microemulsion liquids, the microemulsion has relatively small consumption of emulsifying agents, and has better stability after a long time, and can not be layered for more than 10 years.
The microemulsion of the scheme can be applied to toner, and specific application is as follows.
A microemulsion toner consists of 96.1-97.1% of toner A phase, 2-2.4% of toner B phase, 0.1-0.3% of toner C phase and 0.8-1.2% of toner D phase.
The toner A phase is water phase, the toner B phase is microemulsion phase, the toner C phase is polymer phase, and the toner D phase is preservative phase.
The toner A phase consists of 81.14% -88.11% of water, 0.01% -0.02% of citric acid, 0.01% -0.02% of sodium citrate, 0.01% -0.02% of EDTA disodium, 0.2% -0.4% of trehalose, 0.02% -0.04% of sodium hyaluronate, 0.04% -0.06% of nano sodium hyaluronate, 0.2% -0.4% of 1, 2-pentanediol, 3% -5% of butanediol, 2% -4% of propylene glycol, 2.5% -3.1% of hydrated gel and 1.2% -1.8% of polyethylene glycol-8.
The hydrated gel is glycerin, water, glycerin acrylate/acrylic acid copolymer.
The toner B phase adopts the microemulsion.
The toner C phase is sodium polyacryl dimethyl taurate.
The toner D phase consists of 0.1-0.4% of 1, 2-hexanediol, 0.2-0.4% of ethylhexyl glycerol and 0.3-0.5% of phenoxyethanol.
Examples 1-3 of the toner are shown in the following table:
table 1 toner composition formulation table
The preparation process of the microemulsion toner comprises the following steps:
(1) mixing the toner A, stirring for 8-15 minutes to transparent state, wherein the stirring temperature is 60-70 ℃ and the stirring speed is 250-350rpm; the stirring time is preferably 10 minutes, the temperature is preferably 65℃and the speed is preferably 300rpm.
(2) Adding the toner B phase, stirring for 4-8 minutes at 40-50 ℃ and at 400-600rpm; the stirring time is preferably 5 minutes, the temperature is preferably 45℃and the speed is preferably 500rpm.
(3) Adding the toner C phase, stirring for 8-15 minutes at 40-50 ℃ and at 600-1000rpm; the stirring time is preferably 10 minutes, the temperature is preferably 45℃and the speed is preferably 800rpm.
(4) Adding the toner D phase, stirring for 2-3 minutes at 30-40 ℃ and at 400-600rpm; the stirring time is preferably 2 minutes, the temperature is preferably 35℃and the speed is preferably 500rpm.
The above embodiments are only for illustrating the technical concept and features of the present invention, and are intended to enable those skilled in the art to understand the content of the present invention and to implement the same, but are not intended to limit the scope of the present invention, and all equivalent changes or modifications made according to the spirit of the present invention should be included in the scope of the present invention.
Claims (10)
1. A skin-friendly stable microemulsion characterized by: consists of 7 to 9 percent of oleyl alcohol polyether-5, 3 to 5 percent of polysorbate-20, 3.3 to 5.3 percent of solubilizer, 1 to 1.6 percent of PEG/PPG/polybutylene glycol-8/5/3 glycerin, 3.5 to 4.5 percent of neopentyl glycol dicaprylate/dicaprate, 12 to 14 percent of propylene glycol, 3.3 to 5.3 percent of butanediol, 2.4 to 3.2 percent of polyethylene glycol-8 and 52.1 to 64.5 percent of water.
2. The skin-friendly stable microemulsion according to claim 1, wherein: the solubilizer is one or more of coco polyether-7, PPG-1-PEG-9 month Gui Erchun ether and PEG-40 hydrogenated castor oil.
3. A process for preparing a skin-friendly stable microemulsion according to claim 1, comprising the steps of:
(1) mixing the microemulsion A phase, stirring for 4-8 minutes at normal temperature to a transparent state, wherein the stirring speed is 150-250rpm;
the microemulsion A phase is an emulsifier phase, and the emulsifier phase comprises 7% -9% of oleyl alcohol polyether-5, 3% -5% of polysorbate-20, 3.3% -5.3% of solubilizer, and 1% -1.6% of PEG/PPG/polybutylene glycol-8/5/3 glycerol;
(2) adding the phase B of the microemulsion, stirring for 8-15 minutes at normal temperature to a transparent state, wherein the stirring speed is 600-1000rpm;
the microemulsion B phase is an oil phase, and the oil phase is 3.5% -4.5% of neopentyl glycol dicaprylate/dicaprate;
(3) adding the microemulsion C phase, stirring at normal temperature for 8-15 min to transparent state, and stirring at 600-1000rpm;
the microemulsion C phase is a solvent phase, and the solvent phase comprises 12% -14% of propylene glycol, 3.3% -5.3% of butanediol and 2.4% -3.2% of polyethylene glycol-8;
(4) adding the D phase of the microemulsion, stirring for 4-8 minutes at normal temperature to a transparent state, wherein the stirring speed is 250-350rpm;
the microemulsion D phase is water phase, and the water phase is 52.1% -64.5% of water.
4. A process for the preparation of a skin-friendly stable microemulsion according to claim 3, wherein: the solubilizer is one or more of coco polyether-7, PPG-1-PEG-9 month Gui Erchun ether and PEG-40 hydrogenated castor oil.
5. Use of a skin-friendly stable microemulsion according to claim 1, wherein: the toner is applied to toner.
6. A microemulsion toner is characterized in that: consists of 96.1 to 97.1 percent of toner A phase, 2 to 2.4 percent of toner B phase, 0.1 to 0.3 percent of toner C phase and 0.8 to 1.2 percent of toner D phase; the toner A phase is a water phase, the toner B phase is a microemulsion phase, the toner C phase is a polymer phase, and the toner D phase is a preservative phase; the toner B phase consists of oleyl alcohol polyether-5, polysorbate-20, a solubilizer, PEG/PPG/polybutylene glycol-8/5/3 glycerin, neopentyl glycol dicaprylate/dicaprate, propylene glycol, butylene glycol, polyethylene glycol-8 and water.
7. The microemulsion toner of claim 6, wherein: the toner A phase consists of water, citric acid, sodium citrate, EDTA disodium, trehalose, sodium hyaluronate, nano sodium hyaluronate, 1, 2-pentanediol, butanediol, propylene glycol, hydrated gel and polyethylene glycol-8.
8. The microemulsion toner of claim 6, wherein: the solubilizer is one or more of coco polyether-7, PPG-1-PEG-9 month Gui Erchun ether and PEG-40 hydrogenated castor oil.
9. The microemulsion toner of claim 6, wherein: the toner C phase is sodium polyacryl dimethyl taurate, and the toner D phase consists of 1, 2-hexanediol, ethylhexyl glycerol and phenoxyethanol.
10. A process for preparing the microemulsion toner of claim 6, comprising the steps of:
(1) mixing the toner A, stirring for 8-15 minutes to transparent state, wherein the stirring temperature is 60-70 ℃ and the stirring speed is 250-350rpm;
(2) adding the toner B phase, stirring for 4-8 minutes at 40-50 ℃ and at 400-600rpm;
(3) adding the toner C phase, stirring for 8-15 minutes at 40-50 ℃ and at 600-1000rpm;
(4) adding the toner D phase, stirring for 2-3 min at 30-40deg.C and stirring speed of 400-600rpm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310630093.5A CN116602880A (en) | 2023-05-31 | 2023-05-31 | Skin-friendly stable microemulsion and preparation process and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202310630093.5A CN116602880A (en) | 2023-05-31 | 2023-05-31 | Skin-friendly stable microemulsion and preparation process and application thereof |
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| CN202310630093.5A Pending CN116602880A (en) | 2023-05-31 | 2023-05-31 | Skin-friendly stable microemulsion and preparation process and application thereof |
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| Country | Link |
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| CN (1) | CN116602880A (en) |
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