CN116602310A - Agricultural composition containing abamectin and fenoxycarb - Google Patents
Agricultural composition containing abamectin and fenoxycarb Download PDFInfo
- Publication number
- CN116602310A CN116602310A CN202310626826.8A CN202310626826A CN116602310A CN 116602310 A CN116602310 A CN 116602310A CN 202310626826 A CN202310626826 A CN 202310626826A CN 116602310 A CN116602310 A CN 116602310A
- Authority
- CN
- China
- Prior art keywords
- fenoxycarb
- abamectin
- composition
- destruxin
- avermectin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005898 Fenoxycarb Substances 0.000 title claims abstract description 55
- HJUFTIJOISQSKQ-UHFFFAOYSA-N fenoxycarb Chemical compound C1=CC(OCCNC(=O)OCC)=CC=C1OC1=CC=CC=C1 HJUFTIJOISQSKQ-UHFFFAOYSA-N 0.000 title claims abstract description 54
- 239000000203 mixture Substances 0.000 title claims abstract description 52
- 239000005660 Abamectin Substances 0.000 title claims abstract description 51
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 title claims abstract description 35
- 229950008167 abamectin Drugs 0.000 title claims abstract description 35
- XIYSEKITPHTMJT-OCCJOITDSA-N Destruxin a Chemical compound O=C1[C@@H](CC=C)OC(=O)CCNC(=O)[C@H](C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CCCN21 XIYSEKITPHTMJT-OCCJOITDSA-N 0.000 claims abstract description 17
- 230000000749 insecticidal effect Effects 0.000 claims description 18
- 239000002270 dispersing agent Substances 0.000 claims description 9
- 238000009736 wetting Methods 0.000 claims description 8
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical group CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 4
- 229910019142 PO4 Inorganic materials 0.000 claims description 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
- 239000010452 phosphate Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 21
- 241000607479 Yersinia pestis Species 0.000 abstract description 17
- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical compound C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 abstract description 16
- 239000002689 soil Substances 0.000 abstract description 16
- 239000000575 pesticide Substances 0.000 abstract description 15
- 108010066174 destruxin A Proteins 0.000 abstract description 14
- XIYSEKITPHTMJT-UHFFFAOYSA-N destruxin-A Natural products O=C1C(CC=C)OC(=O)CCNC(=O)C(C)N(C)C(=O)C(C(C)C)N(C)C(=O)C(C(C)CC)NC(=O)C2CCCN21 XIYSEKITPHTMJT-UHFFFAOYSA-N 0.000 abstract description 14
- 231100000419 toxicity Toxicity 0.000 abstract description 9
- 230000001988 toxicity Effects 0.000 abstract description 9
- 230000029087 digestion Effects 0.000 abstract description 5
- 239000004480 active ingredient Substances 0.000 abstract description 4
- 241000500437 Plutella xylostella Species 0.000 abstract description 3
- 230000000857 drug effect Effects 0.000 abstract description 3
- -1 fenoxycarb compound Chemical class 0.000 abstract description 3
- 241001124076 Aphididae Species 0.000 abstract description 2
- 241000254127 Bemisia tabaci Species 0.000 abstract description 2
- 238000013329 compounding Methods 0.000 abstract description 2
- 238000005259 measurement Methods 0.000 abstract 1
- 241000238631 Hexapoda Species 0.000 description 23
- 239000003795 chemical substances by application Substances 0.000 description 14
- 238000012360 testing method Methods 0.000 description 14
- 241000196324 Embryophyta Species 0.000 description 11
- 239000012752 auxiliary agent Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000002360 preparation method Methods 0.000 description 6
- 230000002195 synergetic effect Effects 0.000 description 6
- 241000238876 Acari Species 0.000 description 5
- 230000001276 controlling effect Effects 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 230000002147 killing effect Effects 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 231100000674 Phytotoxicity Toxicity 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000000361 pesticidal effect Effects 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- GJUABKCEXOMRPQ-UHFFFAOYSA-N 1-[(2,5-dimethoxyphenyl)diazenyl]naphthalen-2-ol Chemical compound COC1=CC=C(OC)C(N=NC=2C3=CC=CC=C3C=CC=2O)=C1 GJUABKCEXOMRPQ-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000207199 Citrus Species 0.000 description 2
- QWCKQJZIFLGMSD-GSVOUGTGSA-N D-alpha-aminobutyric acid Chemical compound CC[C@@H](N)C(O)=O QWCKQJZIFLGMSD-GSVOUGTGSA-N 0.000 description 2
- 241000255925 Diptera Species 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 241000488583 Panonychus ulmi Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 235000020971 citrus fruits Nutrition 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 229910021641 deionized water Inorganic materials 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 230000002262 irrigation Effects 0.000 description 2
- 238000003973 irrigation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000029052 metamorphosis Effects 0.000 description 2
- 239000004530 micro-emulsion Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 230000007928 solubilization Effects 0.000 description 2
- 238000005063 solubilization Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 239000003053 toxin Substances 0.000 description 2
- 231100000765 toxin Toxicity 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 241000238421 Arthropoda Species 0.000 description 1
- 241001674044 Blattodea Species 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000257303 Hymenoptera Species 0.000 description 1
- 241000256602 Isoptera Species 0.000 description 1
- 241000488581 Panonychus citri Species 0.000 description 1
- 241001466030 Psylloidea Species 0.000 description 1
- 241000517830 Solenopsis geminata Species 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 241000255901 Tortricidae Species 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 231100000676 disease causative agent Toxicity 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000000967 entomopathogenic effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000003958 fumigation Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000003630 growth substance Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000366 juvenile effect Effects 0.000 description 1
- 230000001418 larval effect Effects 0.000 description 1
- 239000003120 macrolide antibiotic agent Substances 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- PSZYNBSKGUBXEH-UHFFFAOYSA-M naphthalene-1-sulfonate Chemical group C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-M 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000007830 nerve conduction Effects 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000002981 neuropathic effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002420 orchard Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 231100000194 ovacidal Toxicity 0.000 description 1
- 230000003151 ovacidal effect Effects 0.000 description 1
- 230000001769 paralizing effect Effects 0.000 description 1
- 230000003071 parasitic effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229940051841 polyoxyethylene ether Drugs 0.000 description 1
- 229920000056 polyoxyethylene ether Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930000044 secondary metabolite Natural products 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000004562 water dispersible granule Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 239000004563 wettable powder Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/12—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, neither directly attached to a ring nor the nitrogen atom being a member of a heterocyclic ring
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/32—Ingredients for reducing the noxious effect of the active substances to organisms other than pests, e.g. toxicity reducing compositions, self-destructing compositions
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/02—Acaricides
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
- A01P7/00—Arthropodicides
- A01P7/04—Insecticides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Insects & Arthropods (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticide compounding, and relates to an agricultural composition containing abamectin and fenoxycarb. The active ingredients of the composition comprise avermectin and fenoxycarb, and the ratio of the avermectin to the fenoxycarb is 12:1-1:5 in terms of mass ratio. According to the invention, after the abamectin and the fenoxycarb are compounded through indoor toxicity measurement, the abamectin and fenoxycarb compound pesticide composition has a good control effect on common pests such as aphids, bemisia tabaci and plutella xylostella in a given proportioning range. In addition, the invention further combines abamectin, fenoxycarb and destruxin A, and the invention can effectively prolong the drug effect and accelerate the residual digestion of the composition in soil.
Description
Technical Field
The invention belongs to the technical field of pesticide compounding, and relates to an agricultural composition containing abamectin and fenoxycarb.
Background
Avermectin is a macrolide disaccharide compound with CAS accession number: 71751-41-2 has the advantages of contact killing, stomach toxicity and strong permeability. It is a natural product separated from soil microbe, and has the functions of killing insects and mites, killing stomach toxin, and weak fumigation, and has no systemic action. But has strong penetration to the leaves, can kill the pests under the epidermis, and has long residual effect. The insecticidal composition does not kill eggs, and has the action mechanism which is different from that of a common insecticide in that the insecticidal composition interferes with neurophysiologic activity and stimulates release of r-aminobutyric acid, the r-aminobutyric acid has an inhibitory effect on nerve conduction of arthropods, and the mites become paralytic symptoms when mites, insects and larvae come into contact with the insecticide, do not take food after no activity, and die after 2-4 days. The insect is slow to kill because it is not caused to dehydrate rapidly. However, although the natural enemies of predatory and parasitic are directly killed, the damage to beneficial insects is small because of less residue on the plant surface. Has obvious effect on the root of the festival line worm.
The fenoxycarb has the chemical name of 2- (p-phenoxy) ethyl carbamate, is a non-terpene carbamate compound, has stomach toxicity and contact killing effects, has the effect of insect growth regulator, and has broad insecticidal spectrum; but its insecticidal action is non-neuropathic, manifests as strong juvenile hormonal activity against a variety of insects, can lead to ovicidal, inhibition of metamorphosis in adult stages and molting in larval stages, causes death of larvae in postpungent or pupal stages, is specific to insecticidal, and is harmless to bees and beneficial organisms. The fenoxycarb is mainly used for warehouses, preventing and controlling stored pests, and the well has the effect of regulating the growth of the insects, such as destroying the special metamorphosis of the insects, spraying the grain bins to prevent the reproduction of coleopteran and lepidopteran pests, spraying powder to indoor cracks to prevent and control cockroaches, fleas and the like. Can be made into bait for preventing and curing fire ant, termite and other ant colony, and can be applied in water to inhibit mosquito larva from developing into adult mosquito on cotton field, orchard, vegetable garden and ornamental plant, and can effectively prevent and cure psyllid, scale, leaf roller and other pests with resistance to current common pesticides.
Destruxin (destruxin) is a secondary metabolite of the entomopathogenic fungus, destruxin (Metarhiziuwm anisopliae var. Anitoplia), and is an important causative agent of destruxin. The destruxin has the biological activities of disinsection, antivirus, anticancer and the like, has the characteristics of brand new action mechanism, easy degradation and no residue different from the existing pesticide, and has important economic significance in developing and utilizing the destruxin. The destruxin A is the destruxin with the widest distribution and the highest content, has good control effect on aphids, bemisia tabaci, xiaocai and the like, and has good application prospect.
Due to the large and even unreasonable use of avermectin or fenoxycarb for a long period of time, various insect pests develop different degrees of resistance to avermectin or fenoxycarb. In addition, the environmental impact of avermectin or fenoxycarb, in particular the final residual quantity in the soil, also requires a certain attention. The adsorption of pesticides by soil is a major factor affecting the migration, retention and transformation of pesticides in the soil environment, and at the same time, it also directly affects the biological activity of pesticides, and has been considered as an important process for controlling the environmental behavior of pesticides. The combination of different medicaments for controlling pests is an effective means for saving time and labor, saving cost, reducing the dosage of the medicaments and delaying the drug resistance of the pests. The inventor of the patent application, through intensive research, explored an agricultural composition containing abamectin and fenoxycarb, the combined use of the composition has excellent control effect on common pests and shows synergistic effect, the composition also does not appear in known documents, and the person of ordinary skill in the art is difficult to know the beneficial effect of the composition for controlling plant pests.
Disclosure of Invention
The invention aims to provide an agricultural composition containing abamectin and fenoxycarb, which has excellent control effect on plant insect pests. The invention further aims at reducing the stress on plants after the abamectin and the fenoxycarb are compounded and reducing the phytotoxicity on the plants after the abamectin and the fenoxycarb are compounded while maintaining a better pest control effect. The invention also aims to compound the avermectin and the fenoxycarb, prepare the dosage form convenient to apply by adding the auxiliary agent, improve the solubilization of the avermectin and the fenoxycarb on soil, prolong the pesticide effect, accelerate the residual digestion of the composition in the soil and reduce the influence of the composition on the environment.
Based on the purposes, the invention provides an agricultural composition containing abamectin and fenoxycarb, wherein the ratio of the abamectin to the fenoxycarb is 12:1-1:5 in terms of mass ratio.
Those skilled in the art can easily know that the pesticide effect of the agricultural composition is improved, the occurrence of drug resistance is avoided, and a plurality of pesticides are combined or combined, but whether the control effect of the combined or combined pesticides is synergistic or not is difficult to expect because the inherent mechanism of each component is unknown. The inventor has conducted intensive experiments, and has found that the insecticidal composition provided by the invention has excellent control effects on piercing-sucking mouthpart pests according to comprehensive effect assessment shown by field experiments, and is better than the use effect of a single dose.
Preferably, in the agricultural insecticidal composition provided by the invention, the ratio of abamectin to fenoxycarb is 9.8:1 in terms of mass ratio.
Further, the agricultural insecticidal composition provided by the invention further comprises destruxin A.
Further, in the agricultural insecticidal composition provided by the invention, the ratio of fenoxycarb to destruxin A is 4:1 in terms of mass ratio.
According to the actual application requirement, the composition can be prepared into one of dosage forms such as aqueous emulsion, microemulsion, suspending agent, wettable powder, water dispersible granule and the like according to a method known by a person skilled in the art. The functional composition also contains an auxiliary agent required for preparing a pesticide preparation, and the auxiliary agent can be one or a mixture of a plurality of solvents, emulsifying agents, wetting agents, stabilizing agents, dispersing agents, thickening agents, pH regulators, defoamers, antifreezing agents, fillers and the like. The auxiliary agents of the invention can be all known substances, such as various auxiliary agents commonly used in pesticide preparations, and can be changed according to different conditions.
Furthermore, in the agricultural insecticidal composition provided by the invention, in order to prolong the drug effect and accelerate the residual digestion of the composition in soil, the agricultural insecticidal composition further comprises an auxiliary agent, wherein the auxiliary agent comprises a penetrating agent and a wetting dispersing agent, the penetrating agent is azone, and the wetting dispersing agent is alkylphenol ethoxylate phosphate.
The application mode can adopt spraying, root irrigation, root soaking, seed soaking, pouring, throwing, broadcasting, ditch application, cave application and the like. The spray treatment is preferable when the pests are prevented, and the preferred dosage forms for preventing the pests are aqueous emulsion, microemulsion and suspending agent.
Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects or advantages:
compared with the prior art, the main contribution of the invention is to provide an agricultural composition containing abamectin and fenoxycarb, and the composition has excellent control effect on plant insect pests. The inventor of the patent conducts field efficacy test on the composition, and discovers that the composition has better control effect on plant pests than single-dose application in the given proportioning range, thus showing that the composition has synergistic effect. The invention also contributes to the addition of the destruxin A for reducing the stress on plants after the abamectin and the fenoxycarb are compounded and reducing the phytotoxicity on the plants after the abamectin and the fenoxycarb are compounded. A further contribution of the invention is to prolong the drug effect and accelerate the residual digestion of the composition in soil by selecting the auxiliary agent.
Detailed Description
The following describes the technical aspects of the present invention with reference to examples, but the present invention is not limited to the following examples.
Example 1
The embodiment provides a binary compound composition containing abamectin and fenoxycarb.
Avermectin was purchased from Guangzhou, uighur, and fenoxycarb was purchased from Hubei Xinrun chemical Co.
The coating comprises the following components in percentage by weight: the active ingredients (avermectin and fenoxycarb, the mass ratio of the avermectin to the fenoxycarb is 9.8:1) are 30%, the penetrant (azone) is 5%, the wetting dispersant (alkylphenol ethoxylate phosphate) is 6%, the xanthan gum is 0.2%, the ethylene glycol is 3%, the sodium benzoate is 0.2%, the silicone oil is 0.3%, and the balance is deionized water.
The preparation process comprises the following steps: and (3) after fully mixing the components according to the weight percentage, slowly adding the components into deionized water, and stirring for 1h to obtain the composition.
Example 2
The embodiment provides a ternary compound composition containing abamectin, fenoxycarb and destruxin A.
Destruxin a was purchased from singapore prim bioengineering limited.
The preparation method is the same as in example 1, except that the active ingredients are abamectin + fenoxycarb + destruxin A; the ratio of the avermectin to the fenoxycarb to the destruxin A is 12:1:3 in terms of mass ratio.
Comparative examples
The embodiment provides a binary compound composition containing abamectin and fenoxycarb.
The preparation method is the same as in example 1, except that the penetrant is an organosilicon wetting agent, and the wetting dispersant is naphthalene sulfonate.
Example 3
The embodiment provides an indoor combined toxicity test of an agricultural insecticidal composition containing abamectin and fenoxycarb on plutella xylostella.
Test insects: and indoor tired rearing three-instar larvae of plutella xylostella with the same size and physiological state.
Test agent: avermectin, fenoxycarb and destruxin A.
The test method comprises the following steps: the method for preparing the leaf by using the leaf by clamping the toxin refers to the national agricultural industry Standard NY/T1154.2-2006 of the people's republic of China, and the specific method is as follows.
Firstly, a puncher with the diameter of 1cm is used for punching leaf butterfly, and the leaf butterfly is placed in a culture dish for moisturizing. Then, each treatment agent is dripped into 1 mu L of liquid medicine from low concentration by a capillary dropper, after the solvent volatilizes, the liquid medicine is combined with another piece of leaf butterfly coated with starch paste to prepare a toxicity-clamping leaf butterfly, and the preparation is placed in the hole of a 12-hole tissue culture plate. Finally, 1 insect test is connected in each hole of the tissue culture plate, and the tissue culture plate is placed in an intelligent insect-raising chamber with the temperature of 26+/-1 ℃ and the relative humidity of 70%. After 2-4 hours of insect inoculation, after the tested insects take the medicine-containing leaf butterfly, adding clean feed into the holes of the culture plate to continue feeding until investigation, and eliminating the tested insects which do not take a whole leaf butterfly. 4 replicates per treatment, no less than 12 toxin-trapping She Die per replicate, and corresponding organic solvent treatments without agent were used as controls. The death of the test insects was investigated 24 hours after the treatment, and the total number of insects and the number of dead insects were recorded.
Statistical analysis was performed using SPSS statistical analysis software to calculate LC for each agent 50 And the co-toxicity coefficient (CTC value) of the mixture was calculated according to the grand cloud Pei method, and the test results are shown in Table 1.
Measured virulence index (ATI) = (standard agent LC 50 Reagent LC 50 )×100。
Theoretical Toxicity Index (TTI) =a agent toxicity index x percentage of agent toxicity index in mixture + B agent toxicity index x percentage of agent toxicity in mixture.
Co-toxicity coefficient (CTC) = [ actual drug susceptibility index (ATI)/theoretical drug susceptibility index (TTI) ] x 100.
The classification standard is based on the combination effect of NY/T11547.7-2006 pesticides: the co-toxicity coefficient (CTC) is more than or equal to 120, and the synergistic effect is shown; the cotoxicity coefficient (CTC) is less than or equal to 80 and shows antagonism; a co-toxicity coefficient (CTC) of 80 < 120 shows additive effect.
TABLE 1 indoor Combined toxicity determination
From the above table 1, it can be seen that the mixture ratio of abamectin and fenoxycarb is shown as additive effect when 20:1 and 1:10, and as synergistic effect when the mixture ratio of abamectin and fenoxycarb is 12:1-1:5, wherein the co-toxicity coefficient reaches 163.87 when the mixture ratio of abamectin and fenoxycarb is 9.8:1. In addition, when the ratio of the abamectin to the fenoxycarb is between 12:1 and 1:5, and the ratio of the fenoxycarb to the destruxin A is 4:1, the ternary combination of the abamectin, the fenoxycarb and the destruxin A also shows a synergistic effect, and the co-toxicity coefficients are all larger than 120.
Example 4
The embodiment provides an agricultural insecticidal composition containing abamectin and fenoxycarb for controlling citrus red mites.
The test was performed in Guiyang, guizhou province; the citrus varieties are orange, the soil type of the test land is yellow soil, the soil fertility is medium, the test land is smooth, the irrigation condition is good, the cultivation condition of the test area is consistent, and the tree age is 6 years. The test groups are shown in Table 2, and the test agent amount is treated with 10000 times of diluent containing 30% of effective component, and 80kg/667m of the diluent is sprayed by using a Gongnong-16 type manual sprayer 2 Is sprayed on the front and back surfaces of citrus leaves uniformly. Clear water was used as a blank. The area of each cell takes the naturally cultivated fruit trees as a unit, 4 plants are repeated for 4 times per cell, and the cells are arranged in random groups.
Table 2: test group
The number of live mites was investigated before the application, and the number of residual live mites was investigated at 1d, 7d, 10d, and 20d after the application, respectively, while the phytotoxicity and the influence on other organisms were investigated. Every treatment surveys 1 tree, 5 leaves are fixed in the east, south, west, north and middle five directions, the label is put on a card, the leaves are directly observed by using a handheld magnifying glass, the quantity of citrus red spiders moving on 25 leaves is surveyed, and each repeated control effect is calculated according to the following formula.
Control effect = [1- (number of insects before administration of blank control group x number of insects after administration of treatment group)/(number of insects after administration of blank control group x number of insects before administration of treatment group) ] ×100%
Pesticide soil residue: weighing 20.0g of soil sample in a 100mL plastic centrifuge tube, adding 20.0mL of water, mixing uniformly, adding 40.0mL of acetonitrile, oscillating and extracting for 30min on a water bath constant temperature oscillator at 30 ℃, then adding 3.0g of sodium chloride into the centrifuge tube, continuing oscillating for 5min, centrifuging for 10min at 3000 r.min, taking 20.0mL of supernatant, blowing nitrogen in a water bath at 80 ℃ until the supernatant is nearly dry, dissolving residues in the beaker by using methanol, and passing through an amino column; and (3) methanol is used for fixing the volume to 5.0mL, HPLC is carried out on a machine to measure the residual quantity of the avermectin, the fenoxycarb or the destruxin A, and the digestion time of the avermectin, the fenoxycarb or the destruxin A which is not detected (less than 0.02 mg/L) is counted.
Table 3: test results
As shown in Table 3, the agricultural insecticidal composition containing abamectin and fenoxycarb provided by the invention has a better control effect on citrus red spiders, and the control effect of binary combination of abamectin and fenoxycarb or ternary combination of abamectin, fenoxycarb and destruxin A is better than that of each component single agent. Particularly, when the penetrant is azone and the wetting dispersant is alkylphenol polyoxyethylene ether phosphate, the pesticide effect can be obviously prolonged, and the degradation of abamectin and fenoxycarb in soil can be accelerated. This may be related to the fact that the penetrant and wetting dispersant enhance the adhesion of the active ingredient to the foliage and enhance the solubilization of the avermectin and fenoxycarb in the soil.
The present invention may be better implemented as described above, and the above examples are merely illustrative of preferred embodiments of the present invention and not intended to limit the scope of the present invention, and various changes and modifications made by those skilled in the art to the technical solution of the present invention should fall within the scope of protection defined by the present invention without departing from the spirit of the design of the present invention.
Claims (5)
1. An agricultural composition containing abamectin and fenoxycarb is characterized in that the ratio of the abamectin to the fenoxycarb is 12:1-1:5 in terms of mass ratio.
2. The agricultural insecticidal composition according to claim 1, wherein the ratio of abamectin to fenoxycarb is 9.8:1 in mass ratio.
3. An agricultural insecticidal composition according to claim 1 further comprising destruxin a.
4. An agricultural insecticidal composition according to claim 3, wherein the ratio of fenoxycarb to destruxin a is 4:1 in mass ratio.
5. The agricultural insecticidal composition of claim 1, further comprising an adjuvant comprising a penetrant and a wetting dispersant, wherein the penetrant is azone and the wetting dispersant is alkylphenol ethoxylate phosphate.
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