CN116585430A - Traditional Chinese medicine composition with sleep improving effect and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition with sleep improving effect and preparation method and application thereof Download PDFInfo
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- CN116585430A CN116585430A CN202310621693.5A CN202310621693A CN116585430A CN 116585430 A CN116585430 A CN 116585430A CN 202310621693 A CN202310621693 A CN 202310621693A CN 116585430 A CN116585430 A CN 116585430A
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Classifications
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- A—HUMAN NECESSITIES
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
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- A23L2/39—Dry compositions
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- A23L21/00—Marmalades, jams, jellies or the like; Products from apiculture; Preparation or treatment thereof
- A23L21/10—Marmalades; Jams; Jellies; Other similar fruit or vegetable compositions; Simulated fruit products
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8967—Lilium, e.g. tiger lily or Easter lily
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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- Health & Medical Sciences (AREA)
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Abstract
A traditional Chinese medicine composition with sleep improving effect and a preparation method and application thereof relate to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition disclosed by the application comprises jujube kernel, poria cocos, lily, huai wheat, jujube, mulberry concentrated juice and strawberry concentrated juice. The preparation method comprises the following steps: weighing semen Ziziphi Spinosae, crushing, decocting with Poria, bulbus Lilii, fructus Tritici Levis and fructus Jujubae in water for multiple times, concentrating the filtrate under reduced pressure, mixing with Mori fructus concentrated juice and strawberry concentrated juice, and filtering with ceramic membrane to obtain Chinese medicinal composition. The application combines the sub-health characteristics of the crowd in China and the characteristics of traditional Chinese medicines, takes the "inheritance-development-innovation" of the traditional Chinese medicine as the thought, carries out scientific and reasonable compatibility of the components, and examines the preparation process and the drug effect of the components, the obtained traditional Chinese medicine composition has the effects of reinforcing the purgation, reinforcing the benefit, clearing and reinforcing the benefit, can harmonize the stomach with the heat of the liver and yin, and purging the heart fire, and fundamentally improves the insomnia state of the organism, and the preparation process of the application is easy to industrialize.
Description
Technical Field
The application relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition with a sleep improving effect, and a preparation method and application thereof.
Background
Sleep plays a very important role in the physical health of people, and experts point out that with the acceleration of life rhythm and the improvement of social pressure, the problem of sleep disorder tends to rise year by year, and most of people engaged in mental labor have the problem of sleep quality, wherein many people have affected normal life. Long-term insomnia will have a serious impact on quality of life and may be accompanied by the appearance of adverse symptoms such as anxiety, depression, etc. Insomnia problems exist in about 45% of people in China, and the proportion always shows an ascending trend, which becomes a public health issue in China and even worldwide.
At present, the main means for improving sleep include western medicine intervention, traditional Chinese medicine intervention, health care products and the like, wherein the western medicine for improving sleep is mainly sedative hypnotic drugs including barbiturates, benzodiazepines, non-benzodiazepines and the like, but the drugs have side effects of common insomnia rebound, addiction, tolerance and the like. The health care product mainly contains melatonin, which can prolong the total sleeping time, but can not improve the sleeping quality. Therefore, combining the sub-health characteristics of the population in China and the characteristics of traditional Chinese medicines, developing the sub-health state of insomnia improvement by taking traditional Chinese medicines as main means is imperative.
Disclosure of Invention
In order to more effectively and safely improve the insomnia state of the organism from the root, the application provides a traditional Chinese medicine composition with the function of improving sleep, and a preparation method and application thereof.
The technical scheme of the application is as follows:
a traditional Chinese medicine composition with sleep improving effect comprises the following components in parts by weight:
5-8 parts of wild jujube seed, 5-8 parts of poria cocos, 2-7 parts of lily, 15-25 parts of common yam rhizome, 8-15 parts of jujube, 20-40 parts of mulberry juice concentrate and 20-30 parts of strawberry juice concentrate.
Preferably, the composition comprises the following components in parts by weight:
7.5 parts of wild jujube seed, 7.5 parts of poria cocos, 5 parts of lily, 20 parts of common yam rhizome, 12 parts of jujube, 30 parts of mulberry juice concentrate and 25 parts of strawberry juice concentrate.
The application also provides a preparation method of the traditional Chinese medicine composition with the sleep improving effect, which comprises the following steps:
s1, weighing spina date seeds, and crushing to obtain a crushed spina date seed A;
s2, weighing poria cocos, lily, common yam rhizome, wheat and jujube, soaking the poria cocos, the lily, the common yam rhizome and the jujube and the crushed spina date seed A in an extraction solvent for a certain time, heating and decocting, and concentrating filtrate under reduced pressure to obtain a mixed extract B;
s3, mixing the mulberry concentrated juice, the strawberry concentrated juice and the mixed extracting solution B to obtain a mixed extracting solution C;
s4, filtering the mixed extract C through a ceramic membrane to obtain the traditional Chinese medicine composition.
Preferably, the degree of the crushing treatment in step S1 is from treatment to skin crushing.
Preferably, the soaking time in the step S2 is 30-90 min.
Preferably, the extraction solvent is water.
Preferably, the ratio of the decocted liquid to the decoction liquid is 1: (6-12).
Preferably, the times of the decoction are 1 to 3 times, and the time of the decoction is 0.5 to 2 hours each time.
Preferably, the pore size of the ceramic membrane is 200nm.
The application also provides an application of the traditional Chinese medicine composition or the traditional Chinese medicine composition prepared by the preparation method in preparing soft drinks, solid drinks, jellies or cakes.
The pharmacological actions of the application are as follows:
the application combines the theory of traditional Chinese medicine, carries out reasonable compatibility of the components, and researches the preparation process and the drug effect of the components. The prescription contains the medicinal herbs of spine date seed, tuckahoe, lily, huai wheat, jujube, mulberry juice concentrate and strawberry juice concentrate. Wherein semen Ziziphi Spinosae can nourish liver, calm heart, tranquilize mind and arrest sweating; poria has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; the combination of the wild jujube seed and the poria cocos can improve the effect of calming the heart and soothing the nerves. Lily can nourish yin, moisten lung, clear heart and tranquilize mind, and can "calm heart, calm gallbladder, benefit mind and nourish five viscera". Huai wheat Gan Liang, which has the effects of nourishing heart, relieving urgency, relieving restlessness and soothing nerves; jujube sweet Wen Zhirun, has effects of invigorating qi, regulating middle warmer, moistening dryness and relieving urgency; huai wheat and Chinese date are combined to achieve the effects of nourishing heart, soothing nerves and regulating middle energizer and relieving urgency, so that the theory of "liver being bitter and urgent, and rapid eating being sweet and slow" in Su Wen and zang Qi Fang Ji. Mulberry can enrich blood, nourish yin, promote the production of body fluid and moisten dryness, and can nourish liver and kidney, remove heat and nourish yin. The medicines are combined together to play the roles of nourishing heart, soothing nerves, clearing heat and relieving restlessness.
The pharmacology of the other components is as follows:
the semen Ziziphi Spinosae is dry mature seed of Zizyphi Spinosae semen of Rhamnaceae, such as Zizyphi Spinosae semen, var. Spinosa (Bunge) Huex H.F. Chou, and has effects in nourishing heart, nourishing liver, tranquilizing mind, relieving restlessness, insomnia, palpitation, dreaminess, asthenia, hyperhidrosis, and thirst due to body fluid injury. Is mainly used for treating heart deficiency, mental confusion, terror and convulsion, frequent absentmindedness, easy forgetfulness, restlessness, dreaminess, and heart diseases. Modern pharmacological researches show that the semen zizyphi spinosae has the effects of tranquilizing, hypnotizing, improving learning and memory, protecting brain, enhancing immunity and the like, and can play a role in improving sleep.
Poria is dry sclerotium of Polyporaceae fungus Poria penia cocos (Schw.) Wolf, has sweet, light and flat taste, has effects of promoting water penetration, removing dampness, invigorating spleen, tranquilizing, and calming heart, and can be used for treating phlegm retention palpitation, spleen deficiency, anorexia, heart mind restlessness, palpitation, and insomnia. "Shennong Ben Cao Jing" is: the long-term taking of the medicine can calm the spirit, nourish the spirit, and allay hunger and prolong the life. The leaf angel stands for: spleen is the acquired root, spleen is healthy and allaying hunger, and qi and feet are prolonged. Modern pharmacological researches show that Poria has effects of tranquilizing, regulating immunity, protecting liver, and protecting central nerve, immune system, and digestive system, so as to improve sleep.
The lily is dried fleshy scaly leaf of lily plant Paeonia ostii Lilium lancifolium thunder, lily Lilium brownii F.E.Brownvar. Virdulum Baker or Lilium pumilum DC. The Japanese herbal medicine is: can be used for relieving heart, fixing gallbladder, nourishing mind, and nourishing viscera. Modern pharmacological researches have shown that lily has the effects of tranquilizing, hypnotizing, anti-depression, anti-stress injury, relieving cough, eliminating phlegm, regulating immunity, resisting oxidation, reducing blood sugar and the like.
Huai wheat is sweet in taste, slightly cold in nature, and can nourish heart, relieve restlessness, promote urination, stop bleeding, quench thirst and recover sweat, and can tonify deficiency, nourish qi, aid five viscera and strengthen intestines and stomach. "Su Wen" cloud: the cereal of the fire and heart of wheat. It is combined with Zao to exert the actions of nourishing heart, tranquilizing mind, and regulating middle energizer.
Fructus Jujubae is a dried mature fruit of Zizyphus jujuba Mill. Has effects of invigorating spleen, replenishing qi, nourishing blood, and tranquilizing, and can be used for treating spleen deficiency diarrhea, insomnia, night sweat, palpitation, etc. "Benjing" is: pathogenic qi in the heart and abdomen, spleen and stomach are nourished, twelve meridians are helped, stomach qi is calmed, nine orifices are led, less qi is supplemented, body fluids are reduced, the body is deficient, the person is frightened, the limbs are heavy, and the medicine is filled. Modern pharmacological researches have shown that jujube has the effects of enhancing immunity, resisting oxidation, improving cardiovascular system, repairing liver injury, resisting fatigue, improving intestinal tract and the like.
The Mori fructus is dried fruit ear of Morus alba L. Has effects of replenishing blood, nourishing yin, promoting salivation, and moistening dryness, and can be used for treating palpitation, insomnia, dizziness, tinnitus, premature gray hair, and thirst due to fluid consumption. "Bencaojing Shu" is: mulberry, mori fructus, sweet in flavor and cold in flavor, benefits blood and yin, and is a herb for cooling blood and tonifying yin, and its five zang organs belong to yin and benefit yin to benefit five zang organs. When yin is removed, liver and heart are not fire, so spirit is calm and clear, spirit is smart and internal, and yin is complex and white. Modern pharmacological researches have shown that mulberry has the effects of regulating immunity, resisting oxidation, reducing blood sugar, reducing blood lipid and the like.
Compared with the prior art, the application has the following specific beneficial effects:
1. the application combines the theory of traditional Chinese medicine, carries out reasonable compatibility of the components, and researches the preparation process and the drug effect of the components. The medicine can exert the maximum efficacy through the synergistic compatibility of the components; semen Ziziphi Spinosae in the recipe can enter heart and liver meridian, and can nourish liver, calm heart, tranquilize mind and arrest sweating; poria has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; the combination of the two can improve the effect of calming the heart and soothing the nerves. Lily can nourish yin, moisten lung, clear heart and tranquilize mind, and can "calm heart, calm gallbladder, benefit mind and nourish five viscera". Huai wheat Gan Liang, which has the effects of nourishing heart, relieving urgency, relieving restlessness and soothing nerves; jujube sweet Wen Zhirun, has effects of invigorating qi, regulating middle warmer, moistening dryness and relieving urgency; the two herbs are combined to achieve the effects of nourishing heart, soothing the nerves and regulating middle energizer and relieving urgency, so that they are in good agreement with the theory of Su Wen and zang-qi methods, called "liver-bitter and urgent, and rapid and sweet and slow food". Mulberry can enrich blood, nourish yin, promote the production of body fluid and moisten dryness, and can nourish liver and kidney, remove heat and nourish yin. The medicines are combined together to play the roles of nourishing heart, soothing nerves, clearing heat and relieving restlessness. Experiments and comparison prove that the application can prolong the sleep time and can also realize the remarkable shortening of the sleep latency time, thereby improving the sleep quality.
2. The traditional Chinese medicine composition provided by the application has the characteristics of scientific formula, green herb, natural health and zero addition, has a simple preparation process, is easy to operate, has low cost, is easy to industrialize, and can provide a high-level product with guaranteed quality and safety for insomnia people.
Drawings
FIG. 1 is a schematic flow chart of a preparation method of a traditional Chinese medicine composition provided by the application;
FIG. 2 is a graph showing comparison of sleep latency for each group of mice;
fig. 3 is a graph showing sleep extension time versus time for each group of mice.
Detailed Description
In order to make the technical solution of the present application clearer, the technical solution of the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings of the present application, and it should be noted that the following embodiments are only used for better understanding of the technical solution of the present application, and should not be construed as limiting the present application.
The experimental methods used in the following examples are conventional methods unless otherwise specified. The materials, reagents, methods and apparatus used, without any particular description, are those conventional in the art and are commercially available to those skilled in the art.
The terms "comprising," "including," "having," "containing," or any other variation thereof, as used in the following embodiments, are intended to cover a non-exclusive inclusion. For example, a composition, step, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, step, method, article, or apparatus.
When an equivalent, concentration, or other value or parameter is expressed as a range, preferred range, or a range bounded by a list of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when ranges of "1 to 5" are disclosed, the described ranges should be construed to include ranges of "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a numerical range is described herein, unless otherwise indicated, the range is intended to include its endpoints and all integers and fractions within the range. In the description and claims of the application, the range limitations may be combined and/or interchanged, if not otherwise specified, including all the sub-ranges subsumed therein.
The indefinite articles "a" and "an" preceding an element or component of the application are not limited to the requirement (i.e. the number of occurrences) of the element or component. Thus, the use of "a" or "an" should be interpreted as including one or at least one, and the singular reference of an element or component includes the plural reference unless the amount clearly dictates otherwise.
The endpoints of the ranges and any values disclosed in the application are not limited to the precise range or value, and the range or value should be understood to include values close to the range or value. For numerical ranges, one or more new numerical ranges may be found between the endpoints of each range, between the endpoint of each range and the individual point value, and between the individual point value, in combination with each other, and are to be considered as specifically disclosed herein.
Example 1.
Weighing 7.5g of spina date seeds, slightly crushing, and breaking skin to obtain a crushed spina date seed A;
weighing 7.5g of poria cocos, 5g of lily, 20g of common wheat, 12g of Chinese date, soaking for 60min together with the crushed wild jujube seed A, heating and decocting the mixture for 3 times by taking 10 times of water as an extraction solvent, filtering each time by a 200-mesh filter screen, and concentrating the filtrate under reduced pressure (60-80 ℃) to 500mL to obtain a mixed extract B;
filtering the mixed extract B with 200nm ceramic membrane to obtain the Chinese medicinal composition.
Example 2.
Weighing 7.5 parts of spina date seeds, slightly crushing, and breaking skin to obtain a crushed spina date seed A;
weighing 7.5 parts of poria cocos, 5 parts of lily, 20 parts of common wheat, 12 parts of Chinese date, soaking for 60min together with the crushed wild jujube seed A, heating and decocting the mixture for 2 times by taking 8 times of water as an extraction solvent, filtering each time by a 200-mesh filter screen, and concentrating the filtrate under reduced pressure (60-80 ℃) to 500mL to obtain a mixed extract B;
weighing 30 parts of mulberry concentrated juice and 25 parts of strawberry concentrated juice, adding the mulberry concentrated juice and the strawberry concentrated juice into the mixed extract B, and uniformly mixing to obtain a mixed solution C;
filtering the mixed solution C with 200nm ceramic membrane to obtain the Chinese medicinal composition.
Example 3.
Weighing 7.5 parts of spina date seeds, slightly crushing, and breaking skin to obtain a crushed spina date seed A;
weighing 7.5 parts of poria cocos, 5 parts of lily, 20 parts of common wheat, 12 parts of Chinese date, soaking for 60min together with the crushed wild jujube seed A, heating and decocting the mixture for 3 times by taking 10 times of water as an extraction solvent, filtering each time by a 200-mesh filter screen, and concentrating the filtrate under reduced pressure (60-80 ℃) to 500mL to obtain a mixed extract B;
weighing 30 parts of mulberry concentrated juice and 25 parts of strawberry concentrated juice, adding the mulberry concentrated juice and the strawberry concentrated juice into the mixed extract B, and uniformly mixing to obtain a mixed solution C;
filtering the mixed solution C with 200nm ceramic membrane to obtain the Chinese medicinal composition.
Effect example 1.
40 ICR mice of grade 18 g-25 g SPF were adaptively kept in a natural circadian rhythm illumination environment at a temperature of 24+ -2 deg.C, a relative humidity of 60+ -5%, and a natural circadian rhythm illumination environment for 1 week, and then were divided into a blank group, an example 1 group, an example 2 group and an example 3 group, each group of 10 mice was respectively given drinking water (8:00 to 15:00 per day) and a corresponding Chinese medicinal composition liquid (15:00 per day to 8:00 per day) for 30 days in a test period; on day 31, each group of mice was fed with 25mL/kg of the corresponding concentrate of the Chinese medicinal composition (concentrated to 200 mL).
And (3) carrying out a barbital sodium sleep latency experiment, observing whether each traditional Chinese medicine composition can shorten the sleep latency on the basis of the barbital sodium sleep, and if the sleep latency is shortened, indicating that the traditional Chinese medicine composition has a synergistic effect with the barbital sodium. Pre-experiments are carried out before formal experiments, and the dosage of barbital sodium (200 mg/kg-300 mg/kg) which enables the animal to fall asleep 100% but does not enable the animal to fall asleep for too long is determined, and the dosage is used for formal experiments.
After the last administration for 15min, the animals of each group were intraperitoneally injected with 0.2ml/20g barbital sodium, and the effect of each Chinese medicinal composition on the sleep latency of barbital sodium was observed with the disappearance of everlasting reflection as an index.
The results of the experiments are shown in Table 1 and FIG. 2, and the sleep latency of the mice in the blank group was 7.57min. The mice of each example had a reduced sleep latency of 3.71min (P < 0.05), 2.74min (P < 0.05) and 3.94min (P < 0.01), respectively, compared to the blank, and exhibited significant differences (P < 0.05). The results show that the traditional Chinese medicine composition in each embodiment has good effect of reducing sleep latency.
TABLE 1
| Group of | Latency (min) | P value compared to blank group |
| Blank group | 7.57±2.56 | - |
| Example 1 group | 3.86±1.73 | * |
| Example 2 group | 4.83±1.07 | * |
| Example 3 group | 3.63±0.48 | ** |
(the difference compared with the blank group is P < 0.05, P < 0.01.)
Effect example 2.
And (3) carrying out an experiment of prolonging the sleeping time of the pentobarbital sodium, observing whether each traditional Chinese medicine composition can prolong the sleeping time on the basis of hypnotizing the pentobarbital sodium, and if the sleeping time is prolonged, indicating that the traditional Chinese medicine composition has a synergistic effect with the pentobarbital sodium. Preliminary experiments are carried out before formal experiments are carried out, and the dosage (30-60 mg/kg) of pentobarbital sodium which enables the animal to fall asleep 100% but does not enable the animal to fall asleep for too long is determined, and the dosage is used for formal experiments.
After the last administration for 15min, the animals of each group are injected with pentobarbital sodium in the abdominal cavity with the injection amount of 0.2ml/20g, and whether the sleep time of the pentobarbital sodium can be prolonged or not by observing whether the normal reflection disappears or not by taking the normal reflection disappearance as an index.
The experimental results are shown in Table 2 and FIG. 3, and the sleep time of the mice in the blank group is generally 30.5min. The mice of each example had an increased sleep time compared to the blank, respectively increased by 9.33min (P < 0.05), 8.50min (P < 0.05) and 11.33min (P < 0.05), with a significant difference (P < 0.05). The results show that the traditional Chinese medicine composition in each embodiment has good effect of prolonging the sleeping time of mice.
TABLE 2
| Group of | Sleep time (min) | P value compared to blank group |
| Blank group | 30.50±4.86 | - |
| Example 1 group | 39.83±6.15 | * |
| Example 2 group | 39.00±5.06 | * |
| Example 3 group | 41.83±9.92 | * |
In comprehensive comparison, each group of traditional Chinese medicine composition has the effect of improving sleep, and the group of the embodiment 3 > the group of the embodiment 1 > the group of the embodiment 2 shows that the formula and the process of the application are optimal.
In the foregoing, the present application is merely preferred embodiments, which are based on different implementations of the overall concept of the application, and the protection scope of the application is not limited thereto, and any changes or substitutions easily come within the technical scope of the present application as those skilled in the art should not fall within the protection scope of the present application. Therefore, the protection scope of the present application should be subject to the protection scope of the claims.
Claims (10)
1. The traditional Chinese medicine composition with the function of improving sleep is characterized by comprising the following components in parts by weight:
5-8 parts of wild jujube seed, 5-8 parts of poria cocos, 2-7 parts of lily, 15-25 parts of common yam rhizome, 8-15 parts of jujube, 20-40 parts of mulberry juice concentrate and 20-30 parts of strawberry juice concentrate.
2. The traditional Chinese medicine composition with the function of improving sleep as claimed in claim 1, characterized by comprising the following components in parts by weight:
7.5 parts of wild jujube seed, 7.5 parts of poria cocos, 5 parts of lily, 20 parts of common yam rhizome, 12 parts of jujube, 30 parts of mulberry juice concentrate and 25 parts of strawberry juice concentrate.
3. A method for preparing the traditional Chinese medicine composition with sleep improving effect according to claim 1 or 2, which comprises the following steps:
s1, weighing spina date seeds, and crushing to obtain a crushed spina date seed A;
s2, weighing poria cocos, lily, common yam rhizome, wheat and jujube, soaking the poria cocos, the lily, the common yam rhizome and the jujube and the crushed spina date seed A in an extraction solvent for a certain time, heating and decocting, and concentrating filtrate under reduced pressure to obtain a mixed extract B;
s3, mixing the mulberry concentrated juice, the strawberry concentrated juice and the mixed extracting solution B to obtain a mixed extracting solution C;
s4, filtering the mixed extract C through a ceramic membrane to obtain the traditional Chinese medicine composition.
4. The method for preparing a Chinese medicinal composition with sleep improving effect according to claim 3, wherein the crushing treatment in step S1 is performed to the extent of skin breaking.
5. The method for preparing a Chinese medicinal composition with sleep improving effect according to claim 3, wherein the soaking time in step S2 is 30-90 min.
6. The method for preparing a Chinese medicinal composition with sleep improving effect according to claim 3, wherein the extraction solvent is water.
7. The method for preparing a traditional Chinese medicine composition with sleep improving effect according to claim 3, wherein the decoction liquid ratio is 1: (6-12).
8. The method for preparing a Chinese medicinal composition with sleep improving effect according to claim 3, wherein the times of decoction are 1-3 times, and the time of decoction is 0.5-2 h each time.
9. The method for preparing a Chinese medicinal composition with sleep improving effect according to claim 3, wherein the pore diameter of the ceramic membrane is 200nm.
10. Use of a Chinese medicinal composition having sleep improving effect according to claim 1 or 2 or a Chinese medicinal composition prepared by the preparation method according to any one of claims 3 to 9 for preparing soft drink, solid drink, jelly or cake.
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