CN116583501A - 用于治疗与lpa受体活性相关的病症的化合物和组合物 - Google Patents

用于治疗与lpa受体活性相关的病症的化合物和组合物 Download PDF

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CN116583501A
CN116583501A CN202180081636.1A CN202180081636A CN116583501A CN 116583501 A CN116583501 A CN 116583501A CN 202180081636 A CN202180081636 A CN 202180081636A CN 116583501 A CN116583501 A CN 116583501A
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张海珍
M·汉森
A·詹宁斯
雷晖
林熹晨
Q·张
A·科特
A·M·罗文斯基
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Rothschild Biotech
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
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  • Chemical & Material Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN202180081636.1A 2020-10-22 2021-10-21 用于治疗与lpa受体活性相关的病症的化合物和组合物 Pending CN116583501A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CNPCT/CN2020/122794 2020-10-22
CN2020122794 2020-10-22
CN2021113042 2021-08-17
CNPCT/CN2021/113042 2021-08-17
CN2021122851 2021-10-09
CNPCT/CN2021/122851 2021-10-09
PCT/CN2021/125409 WO2022083703A1 (en) 2020-10-22 2021-10-21 Compounds and compositions for treating conditions associated with lpa receptor activity

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US (1) US20240018102A1 (https=)
EP (2) EP4232431B1 (https=)
JP (1) JP2023546742A (https=)
CN (1) CN116583501A (https=)
ES (1) ES3049795T3 (https=)
TW (1) TW202233575A (https=)
WO (1) WO2022083703A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118339149A (zh) * 2021-10-21 2024-07-12 罗特斯生物公司 用于治疗与lpa受体活性相关的病症的化合物和组合物
WO2026002179A1 (en) * 2024-06-28 2026-01-02 Rezubio Pharmaceuticals Co., Ltd Compounds and compositions

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202342017A (zh) 2022-02-25 2023-11-01 美商洛子峰生物有限公司 用於治療與ｌｐａ受體活性相關的病狀的化合物及組合物

Citations (6)

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