CN116583267A8 - 靶向灭活疱疹病毒膏贴药物组合物及其制备方法与应用 - Google Patents
靶向灭活疱疹病毒膏贴药物组合物及其制备方法与应用 Download PDFInfo
- Publication number
- CN116583267A8 CN116583267A8 CN202280006407.8A CN202280006407A CN116583267A8 CN 116583267 A8 CN116583267 A8 CN 116583267A8 CN 202280006407 A CN202280006407 A CN 202280006407A CN 116583267 A8 CN116583267 A8 CN 116583267A8
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- Prior art keywords
- sodium
- plaster
- targeted
- preparation
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000011505 plaster Substances 0.000 title abstract 3
- 241001529453 unidentified herpesvirus Species 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
- 239000000284 extract Substances 0.000 abstract 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 abstract 2
- 239000011780 sodium chloride Substances 0.000 abstract 2
- 235000002639 sodium chloride Nutrition 0.000 abstract 2
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 abstract 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 abstract 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 1
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 abstract 1
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 abstract 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 abstract 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 abstract 1
- 239000004698 Polyethylene Substances 0.000 abstract 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 abstract 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 abstract 1
- 239000000686 essence Substances 0.000 abstract 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 abstract 1
- 229920013818 hydroxypropyl guar gum Polymers 0.000 abstract 1
- 239000001630 malic acid Substances 0.000 abstract 1
- 235000011090 malic acid Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 abstract 1
- 229940052490 naringin Drugs 0.000 abstract 1
- 229930019673 naringin Natural products 0.000 abstract 1
- -1 polyethylene Polymers 0.000 abstract 1
- 229920000573 polyethylene Polymers 0.000 abstract 1
- 239000004323 potassium nitrate Substances 0.000 abstract 1
- 235000010333 potassium nitrate Nutrition 0.000 abstract 1
- 239000008213 purified water Substances 0.000 abstract 1
- 229940085605 saccharin sodium Drugs 0.000 abstract 1
- 229960004029 silicic acid Drugs 0.000 abstract 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 abstract 1
- 239000004299 sodium benzoate Substances 0.000 abstract 1
- 235000010234 sodium benzoate Nutrition 0.000 abstract 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 abstract 1
- 229960004711 sodium monofluorophosphate Drugs 0.000 abstract 1
- 239000004317 sodium nitrate Substances 0.000 abstract 1
- 235000010344 sodium nitrate Nutrition 0.000 abstract 1
- 229940001516 sodium nitrate Drugs 0.000 abstract 1
- 239000001488 sodium phosphate Substances 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 235000010356 sorbitol Nutrition 0.000 abstract 1
- 229940047908 strontium chloride hexahydrate Drugs 0.000 abstract 1
- AMGRXJSJSONEEG-UHFFFAOYSA-L strontium dichloride hexahydrate Chemical compound O.O.O.O.O.O.Cl[Sr]Cl AMGRXJSJSONEEG-UHFFFAOYSA-L 0.000 abstract 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 abstract 1
- 229960000401 tranexamic acid Drugs 0.000 abstract 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 abstract 1
- 235000019801 trisodium phosphate Nutrition 0.000 abstract 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000000230 xanthan gum Substances 0.000 abstract 1
- 229920001285 xanthan gum Polymers 0.000 abstract 1
- 235000010493 xanthan gum Nutrition 0.000 abstract 1
- 229940082509 xanthan gum Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
靶向灭活疱疹病毒膏贴组合物包含有贴、磷酸三钠、苹果酸、山梨糖醇、苯甲酸钠、纤维素胶、香精、糖精钠、柚皮苷、风轮草提取物、黄原胶、聚乙二醇-8、碳酸钙、羟乙基纤维素、羟丙基瓜儿胶、硝酸钠、水合硅石、月桂醇硫酸脂钠、纯净水适量、氯化锶六水合物、凝血酸、两面针提取物、单氟磷酸钠、海盐、硝酸钾和氯化钠。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2021104169343 | 2021-04-19 | ||
| CN202110416934 | 2021-04-19 | ||
| CNPCT/CN2021/000191 | 2021-09-18 | ||
| CN2021000191 | 2021-09-18 | ||
| PCT/CN2022/000056 WO2022206086A1 (zh) | 2021-04-19 | 2022-03-29 | 靶向灭活疱疹病毒膏贴药物组合物及其制备方法与应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN116583267A CN116583267A (zh) | 2023-08-11 |
| CN116583267A8 true CN116583267A8 (zh) | 2024-03-12 |
Family
ID=83457874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202280006407.8A Pending CN116583267A (zh) | 2021-04-19 | 2022-03-29 | 靶向灭活疱疹病毒膏贴药物组合物及其制备方法与应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN116583267A (zh) |
| WO (1) | WO2022206086A1 (zh) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101057953A (zh) * | 2006-04-21 | 2007-10-24 | 陈祖辉 | 对付病毒感染疾患的多靶协同防治制剂 |
| CN102525871B (zh) * | 2012-03-13 | 2013-04-10 | 常熟华港制药有限公司 | 用于预防和治疗复发性口疮的牙膏及制备方法 |
| CN104258067B (zh) * | 2014-09-12 | 2017-08-29 | 皖南医学院 | 一种用于巴布剂的药物组合物、巴布剂及其制备工艺 |
| CN105055230A (zh) * | 2015-08-11 | 2015-11-18 | 刘三猫 | 一种多功用的中药牙膏组合物及其牙膏和制备方法 |
| CN108379139B (zh) * | 2018-03-07 | 2020-12-08 | 济川药业集团有限公司 | 一种防治口腔溃疡的牙膏及其制备方法和应用 |
-
2022
- 2022-03-29 WO PCT/CN2022/000056 patent/WO2022206086A1/zh active Application Filing
- 2022-03-29 CN CN202280006407.8A patent/CN116583267A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022206086A1 (zh) | 2022-10-06 |
| CN116583267A (zh) | 2023-08-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| CI02 | Correction of invention patent application |
Correction item: Classification number Correct: A61K 36/758(2006.01)|A61K 9/70(2006.01)|A61P 31/22(2006.01)|A61K 36/53(2006.01)|A61K 31/7048(2006.01) False: A61K 8/97(2017.01) Number: 32-02 Page: The title page Volume: 39 Correction item: Classification number Correct: A61K 36/758(2006.01)|A61K 9/70(2006.01)|A61P 31/22(2006.01)|A61K 36/53(2006.01)|A61K 31/7048(2006.01) False: A61K 8/97(2017.01) Number: 32-02 Volume: 39 |
|
| CI02 | Correction of invention patent application |