CN1165680A - Medicine for treating chronic kidney disease and its prepn. method - Google Patents
Medicine for treating chronic kidney disease and its prepn. method Download PDFInfo
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- CN1165680A CN1165680A CN 97105127 CN97105127A CN1165680A CN 1165680 A CN1165680 A CN 1165680A CN 97105127 CN97105127 CN 97105127 CN 97105127 A CN97105127 A CN 97105127A CN 1165680 A CN1165680 A CN 1165680A
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Abstract
A medicine in the form of capsule for curing chronic nephritis, nephrotic syndrome and albuminuria with distinct curative effect and no by-effect is prepared from 13 Chinese-medicinl materials such as astragalus root, Chinese angelica root, ginseng, rehmannia root, atractylodes rhizome, etc. through grinding part of ginseng amount (1/3) and sieving; extracting volatile oil from Chinese angelica root, atractylodes rhizome and cinnamon bark; decocting the dregs and other raw materials, concentration, mixing with ginseng powder and volatile oil and loading in capsules.
Description
The present invention relates to a kind of medicine for the treatment of chronic kidney disease and preparation method thereof, it belongs to the Chinese herbal medicine is Chinese patent medicine of feedstock production and preparation method thereof.
Albuminuria is a symptom of acute renal glomerulus disease (as acute glomerulonephritis, rapidly progressive glomerulonephritis) still not, and is a symptom of chronic glomerulus disease (as chronic glomerulonephritis, the nephrotic syndrome), chronic pyelonephritis, anaphy lactoid purpura nephritis, chronic renal failure etc.Treat albuminuria for this reason and just become the key of treatment chronic kidney disease.
Treatment albuminuria first-selection is an adrenal cortex hormones drug at present, but because there is 1, can cause adrenocortical hyperfunction, 2, bring out or increase the weight of to infect, 3, digestive system complication, 4, bring out mental symptom, 5, taking for a long time can be by to hypophysis, the negative feedback of adrenal cortex axle causes shortcomings such as adrenal cortex atrophy and functional defect, and affects the use of this medicine.And the slow renal aid of Chinese patent medicine is owing to its unsatisfactory curative effect, some Western medicine of still having to when the patient takes depend on.
The purpose of this invention is to provide a kind of albuminuria of treatment due to the multiple chronic glomerulus disease that not only can improve, and can improve renal function, without any toxic and side effects, and can be used for nephropathy and be associated with medicine of other disease that can not use adrenal cortex hormones drug, treatment prostate hyperplasia and chronic prostatitis and treatment chronic kidney disease evident in efficacy and preparation method thereof.
Task of the present invention is achieved in that this medicine made by the following weight proportion raw material:
4～12 parts of 1～9 part of Radix Ginsengs of 8～16 parts of Radix Angelicae Sinensis of the Radix Astragali
4～12 parts in 4～12 parts of Poria of 8～16 parts of Rhizoma Atractylodis of Radix Rehmanniae
4～12 parts of 4～12 portions of Rhizoma Coptidis of 4～12 parts of Cortex Moutans of Rhizoma Alismatis
4～12 parts of 4～12 parts of Radix Stephaniae Tetrandrae of Cortex Cinnamomi 4～12 parts of Radix Ophiopogonis
4～12 parts of Fructus Schisandrae Chinensis.
The preferred weight proportioning of above-mentioned each raw material is:
4～10 parts of 2～7 parts of Radix Ginsengs of 10～15 parts of Radix Angelicae Sinensis of the Radix Astragali
6～10 parts in 4～10 parts of Poria of 9～14 parts of Rhizoma Atractylodis of Radix Rehmanniae
6～12 parts of 5～11 portions of Rhizoma Coptidis of 6～10 parts of Cortex Moutans of Rhizoma Alismatis
4～10 parts of 5～11 parts of Radix Stephaniae Tetrandrae of Cortex Cinnamomi 6～12 parts of Radix Ophiopogonis
6～10 parts of Fructus Schisandrae Chinensis.
The optimum weight proportioning of above-mentioned each raw material is:
8 parts of 5 parts of Radix Ginsengs of 13 parts of Radix Angelicae Sinensis of the Radix Astragali
8 parts in 6 parts of Poria of 11 parts of Rhizoma Atractylodis of Radix Rehmanniae
6 parts of 6 portions of Rhizoma Coptidis of 6 parts of Cortex Moutans of Rhizoma Alismatis
7 parts of 8 parts of Radix Stephaniae Tetrandrae of Cortex Cinnamomi 8 parts of Radix Ophiopogonis
8 parts of Fructus Schisandrae Chinensis.
Preparation method of the present invention is:
Radix Ginseng powder with 1/3 amount is broken into fine powder, sieves earlier; Radix Angelicae Sinensis, Rhizoma Atractylodis and Cortex Cinnamomi are extracted volatile oil, and the aqueous solution after distillation device is in addition collected; Radix Angelicae Sinensis, Rhizoma Atractylodis and cinnamomic medicinal residues and remaining Radix Ginseng, the Radix Astragali, Radix Rehmanniae, Poria, Rhizoma Alismatis, Cortex Moutan, Rhizoma Coptidis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis and Fructus Schisandrae Chinensis decoct with water twice, decoct 2 hours for the first time, decoct 1.5 hours for the second time, and collecting decoction filters decocting liquid; Aqueous solution after then will filtering decocting liquid and distilling merges, and concentrated medicament becomes thick paste, adds the Radix Ginseng powder, mix homogeneously, and cold drying is sieved, and spray at last adds the volatile oil of extraction, is loaded on and promptly makes capsule in the capsule.
Medicine of the present invention can also make pill, tablet or powder according to officinal production method.
The present invention gets the Radix Astragali, Radix Ginseng tonifying the lung gas, and Radix Rehmanniae the kidney invigorating essence is full side's monarch drug; Radix Ophiopogonis, Fructus Schisandrae Chinensis reinforcing the heart kidney are ministerial drug; Radix Stephaniae Tetrandrae, Rhizoma Atractylodis, Poria, Rhizoma Alismatis remove damp and clearing heat, and Cortex Moutan, Radix Angelicae Sinensis promoting blood circulation to remove obstruction in the collateral make for assistant.And the Radix Astragali, Radix Ginseng, Radix Ophiopogonis, Fructus Schisandrae Chinensis are allocated the heart, supplementing QI and nourishing YIN mutually in the side; Radix Ginseng, the Radix Astragali, Radix Ophiopogonis, Radix Rehmanniae, Rhizoma Atractylodis match, and go into spleen, boosting qi and nourishing yin; Radix Rehmanniae, Fructus Schisandrae Chinensis, Cortex Cinnamomi match, and go into kidney, tonifying YIN YANG invigorating, promote the circulation of qi and water.Close altogether and form boosting qi and nourishing yin, to set upright gas.Radix Rehmanniae, Radix Ophiopogonis mutual generation between metal and water; Radix Rehmanniae, Fructus Schisandrae Chinensis, Poria, Rhizoma Alismatis, Cortex Moutan, residence LIUWEI DIHUANG WAN meaning are not stayed heresy with the kidney invigorating, fall to let out and just do not hinder; Cortex Cinnamomi, Rhizoma Coptidis, residence hand over safe ball meaning with the kidney of laying one's heart bear, and make the extreme misery blending; The Radix Astragali, Radix Angelicae Sinensis match, and residence Radix Angelicae Sinensis decoction for tonifying blood meaning is with qi-supplementing, blood-engendering.The all medicine compatibilities of the present invention to be reaching boosting qi and nourishing yin, and the purpose of dampness heat clearing away can effectively be treated the chronic renal failure due to deficiency of both QI and YIN, the damp-heat accumulation, chronic glomerulonephritis, the albuminuria of the nephrotic syndrome etc.Through 106 routine observation on Clinical Application, (2 months) its total effective rate 94.34% in a course of treatment.Matched group (slow renal aid) 30 routine total effective rates 26.67% (course of treatment is identical with the present invention).Clinical test results such as following table:
| Group | Total routine number | Alleviate fully | The basic alleviation | Effectively | Invalid | Total effective rate |
| The present invention's (treatment group) | ??106 | ????43 | ????17 | ???40 | ????6 | ????94.34％ |
| Slow renal aid (matched group) | ???30 | ?????0 | ?????2 | ????6 | ???22 | ????26.67％ |
From last table as seen: the treatment group obviously is better than matched group (P＜0.005).Therefore the present invention is to deficiency of both QI and YIN, the chronic nephritis of damp-heat accumulation, and the albuminuria of the nephrotic syndrome etc. has significant curative effect.
Studies show that through pharmacodynamic experiment, the present invention has significant treatment or restitution to rat puromycin nephropathy, with model group mutually specific energy obviously reduce nephropathy animal urine protein content, reduce blood urea nitrogen and creatinine, improve content of hemoglobin, alleviate the pathological lesion of renal tissue, promote or accelerate the recovery of renal tissue structure, show that through acute and chronic toxicity test rat does not have significant toxic reaction, it is good to show that this medicine is taken safety for a long time.
Embodiment 1:
Take by weighing raw material by following proportioning:
The Radix Astragali 365 gram Radix Angelicae Sinensis 135 gram Radix Ginsengs 172 gram Radix Rehmanniae 280 grams
Rhizoma Atractylodis 91 gram Poria 91 gram Rhizoma Alismatis 170 gram Cortex Moutans 170 grams
Rhizoma Coptidis 170 gram Cortex Cinnamomis 272 gram Radix Stephaniae Tetrandrae 170 gram grams Radix Ophiopogonis 91
Fructus Schisandrae Chinensis 91 grams.
Production method is as follows:
Radix Ginseng powder with 1/3 amount is broken into 80 purpose fine powders, sieves earlier; Radix Angelicae Sinensis, Rhizoma Atractylodis and Cortex Cinnamomi are extracted volatile oil, and the aqueous solution after distillation device is in addition collected; Radix Angelicae Sinensis, Rhizoma Atractylodis and cinnamomic medicinal residues and remaining Radix Ginseng, the Radix Astragali, Radix Rehmanniae, Poria, Rhizoma Alismatis, Cortex Moutan, Rhizoma Coptidis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis and Fructus Schisandrae Chinensis decoct with water twice, decocted 2 hours for the first time, decocted 1.5 hours for the second time, merge decocting liquid twice, filter decoction liquor; Aqueous solution after then will filtering decocting liquid and distilling merges, and concentrated medicament becomes thick paste, adds the Radix Ginseng powder, mix homogeneously, and cold drying is sieved, and spray at last adds the volatile oil of extraction, promptly makes capsule in incapsulating.
Embodiment 2:
Take by weighing raw material by following proportioning:
The Radix Astragali 300 gram Radix Angelicae Sinensis 22 gram Radix Ginsengs 272 gram Radix Rehmanniae 365 grams
Rhizoma Atractylodis 170 gram Poria 272 gram Rhizoma Alismatis 90 gram Cortex Moutans 91 grams
Rhizoma Coptidis 90 gram Cortex Cinnamomis 170 gram Radix Stephaniae Tetrandrae 91 gram grams Radix Ophiopogonis 165
Fructus Schisandrae Chinensis 170 grams.
Production method is with embodiment 1.
Embodiment 3:
The Radix Astragali 180 gram Radix Angelicae Sinensis 204 gram Radix Ginsengs 90 gram Radix Rehmanniae 180 grams
Rhizoma Atractylodis 120 gram Poria 170 gram Rhizoma Alismatis 130 gram Cortex Moutans 118 grams
Rhizoma Coptidis 272 gram Cortex Cinnamomis 90 gram Radix Stephaniae Tetrandrae 170 gram grams Radix Ophiopogonis 272
Fructus Schisandrae Chinensis 272 grams.
Production method is with embodiment 1.
Model case: Liu * * male 42 years old
Suddenly anasarca the year before, a large amount of albuminuria, blood fat are higher, through the treatment edema, and albuminuria all alleviates, but fatigue and weak, spirit is not good enough, lusterless complexion, afternoon fever (low grade fever), feverish sensation in the palms and soles, breast gastral cavity painful abdominal mass is vexed, poor appetite, xerostomia be the desire drink not, the few tongue of red tongue, and deep pulse is unable.It is slight to look into edema.Chemical examination: routine blood test Hb10g/L, BUN5.1mmol/L.Routine urinalysis: albumen ++ ++, occult blood+.The tcm diagnosis deficiency of both QI and YIN, damp-heat accumulation disease, the Western medicine diagnose nephrotic syndrome.
Obey medicine of the present invention, each 4, every day three times, hollow clothes.Taking 4 all diseases alleviates.Have a routine urine test albumen ++, occult blood-.Obeyed for 4 weeks again, all diseases all disappear, have a routine urine test, and albumen-, occult blood-, routine blood test Hb13g/L.Recovery from illness.
Example 2: section * * women 26 years old.
The patient once suffered from acute glomerulonephritis in the time of 5 years old, through the treatment transference cure, anasarca appears again in the fatigue of going out in this year, though play still eyelid, ankle edema morning through treating.It is white also to meet the color rolling during prescription on individual diagnosis except that above-mentioned symptom, and weak breath is weak, easy catching a cold, and afternoon low grade fever, feverish sensation in the palms and soles, xerostomia is the desire drink not, and is uncomfortable in chest indigestion and loss of appetite.The few tongue of red tongue, deficient and rapid pulse.Look into the edema of pair of lower extremities moderate.Blood test blood urea nitrogen 7.8mmol/L, urine protein +++, occult blood ++.The tcm diagnosis edema.Deficiency of both QI and YIN, damp-heat accumulation disease.Western medicine diagnose: chronic glomerulonephritis.
Obey medicine of the present invention, every day three times, each 4, hollow clothes.Took medicine for two weeks, edema of lower limbs alleviates, afternoon low grade fever, and feverish sensation in the palms and soles, uncomfortable in chest indigestion and loss of appetite, xerostomia not desire drink disappears urine protein ++, occult blood+.Have rosy cheeks after around the, edema disappears, and spirit takes a turn for the better, and weak alleviating has a routine urine test, albumen ±, occult blood-.Blood urea nitrogen 6.9mmol/L had a blood test in the 9th week.Routine urinalysis albumen ±, occult blood-.Recovery from illness.
Claims (5)
1, a kind of medicine for the treatment of chronic kidney disease is characterized in that: it is the medicament of being made by the following weight proportion raw material:
4～12 parts of 1～9 part of Radix Ginsengs of 8～16 parts of Radix Angelicae Sinensis of the Radix Astragali
4～12 parts in 4～12 parts of Poria of 8～16 parts of Rhizoma Atractylodis of Radix Rehmanniae
4～12 parts of 4～12 portions of Rhizoma Coptidis of 4～12 parts of Cortex Moutans of Rhizoma Alismatis
4～12 parts of 4～12 parts of Radix Stephaniae Tetrandrae of Cortex Cinnamomi 4～12 parts of Radix Ophiopogonis
4～12 parts of Fructus Schisandrae Chinensis.
2, the medicine of treatment chronic kidney disease according to claim 1 is characterized in that: the weight proportion of described each raw material is:
4～10 parts of 2～7 parts of Radix Ginsengs of 10～15 parts of Radix Angelicae Sinensis of the Radix Astragali
6～10 parts in 4～10 parts of Poria of 9～14 parts of Rhizoma Atractylodis of Radix Rehmanniae
6～12 parts of 5～11 portions of Rhizoma Coptidis of 6～10 parts of Cortex Moutans of Rhizoma Alismatis
4～10 parts of 5～11 parts of Radix Stephaniae Tetrandrae of Cortex Cinnamomi 6～12 parts of Radix Ophiopogonis
6～10 parts of Fructus Schisandrae Chinensis.
3, the medicine of treatment chronic kidney disease according to claim 1 is characterized in that: the optimum weight proportioning of described each raw material is:
8 parts of 5 parts of Radix Ginsengs of 13 parts of Radix Angelicae Sinensis of the Radix Astragali
8 parts in 6 parts of Poria of 11 parts of Rhizoma Atractylodis of Radix Rehmanniae
6 parts of 6 portions of Rhizoma Coptidis of 6 parts of Cortex Moutans of Rhizoma Alismatis
7 parts of 8 parts of Radix Stephaniae Tetrandrae of Cortex Cinnamomi 8 parts of Radix Ophiopogonis
8 parts of Fructus Schisandrae Chinensis.
4, according to the medicine of claim 1,2 or 3 described treatment chronic kidney disease, it is characterized in that: described medicament is capsule, pill, tablet or powder.
5, the preparation method of the medicine of treatment chronic kidney disease according to claim 4 is characterized in that: the Radix Ginseng powder with 1/3 amount is broken into fine powder, sieves earlier; Radix Angelicae Sinensis, Rhizoma Atractylodis and Cortex Cinnamomi are extracted volatile oil, and the aqueous solution after distillation device is in addition collected; Radix Angelicae Sinensis, Rhizoma Atractylodis and cinnamomic medicinal residues and remaining Radix Ginseng, the Radix Astragali, Radix Rehmanniae, Poria, Rhizoma Alismatis, Cortex Moutan, Rhizoma Coptidis, Radix Stephaniae Tetrandrae, Radix Ophiopogonis and Fructus Schisandrae Chinensis decoct with water twice, decoct 2 hours for the first time, decoct 1.5 hours for the second time, and collecting decoction filters decocting liquid; Aqueous solution after then will filtering decocting liquid and distilling merges, and concentrated medicament becomes thick paste, adds the Radix Ginseng powder, mix homogeneously, and cold drying is sieved, and spray at last adds the volatile oil of extraction, promptly makes capsule in incapsulating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97105127 CN1057465C (en) | 1997-06-05 | 1997-06-05 | Medicine for treating chronic kidney disease and its prepn. method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 97105127 CN1057465C (en) | 1997-06-05 | 1997-06-05 | Medicine for treating chronic kidney disease and its prepn. method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1165680A true CN1165680A (en) | 1997-11-26 |
| CN1057465C CN1057465C (en) | 2000-10-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 97105127 Expired - Fee Related CN1057465C (en) | 1997-06-05 | 1997-06-05 | Medicine for treating chronic kidney disease and its prepn. method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112353834A (en) * | 2020-12-03 | 2021-02-12 | 中国人民解放军空军军医大学 | Application of two-component Shensu drink in preparation of medicine for preventing and treating chronic kidney injury |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700340B (en) * | 2009-11-16 | 2011-10-05 | 董桂芬 | Oral traditional Chinese medicine composition for treating chronic nephritis |
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1997
- 1997-06-05 CN CN 97105127 patent/CN1057465C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112353834A (en) * | 2020-12-03 | 2021-02-12 | 中国人民解放军空军军医大学 | Application of two-component Shensu drink in preparation of medicine for preventing and treating chronic kidney injury |
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| Publication number | Publication date |
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| CN1057465C (en) | 2000-10-18 |
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