CN116549555A - Cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by liver-lung yin deficiency - Google Patents

Cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by liver-lung yin deficiency Download PDF

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CN116549555A
CN116549555A CN202310497253.3A CN202310497253A CN116549555A CN 116549555 A CN116549555 A CN 116549555A CN 202310497253 A CN202310497253 A CN 202310497253A CN 116549555 A CN116549555 A CN 116549555A
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traditional chinese
chinese medicine
liver
cyclodextrin
lung
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卫晓芸
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Abstract

The invention relates to a traditional Chinese medicine for treating cough and reducing sputum caused by liver-lung yin deficiency, which belongs to the technical field of fertilizer traditional Chinese medicine preparations and comprises the following raw materials in parts by mass: 4-8 parts of fritillaria cirrhosa, 1-5 parts of cassia twig, 1-3 parts of schisandra chinensis, 1-3 parts of paeonia lactiflora and a plurality of auxiliary materials. The Chinese herbaceous peony and fritillary bulb are used for benefiting the yin of the liver and the lung, the cassia twig is used for dispelling exterior and eliminating cold evil, the schisandra fruit is used for astringing the yin of the lung, and the fritillary bulb and the cassia twig are used for promoting blood circulation and regulating the liver and the lung. The beta-cyclodextrin and the modified derivative thereof are used as auxiliary materials to assist in extracting active ingredients in the composite traditional Chinese medicine, and the hydroxyl groups and the glycosidic ether bonds contained in the beta-cyclodextrin and the modified derivative thereof can interact with acceptors and donors of hydrogen bonds and have hydrophobic interactions, so that the beta-cyclodextrin and the modified derivative thereof load traditional Chinese medicine active substances with poor water solubility, the extraction efficiency of bioactive ingredients is improved, the medicine effect is improved, the time required for rehabilitation is reduced, and the beta-cyclodextrin and the modified derivative thereof have the characteristics of strong specificity, good medicine effect and no side effect.

Description

Cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by liver-lung yin deficiency
Technical Field
The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine for treating cough caused by liver-lung yin deficiency and resolving phlegm.
Background
At present, the medicines for treating cough and asthma on the market can be divided into western medicines and traditional Chinese medicines. The western medicines comprise dextromethorphan hydrobromide, pseudoephedrine hydrochloride, ambroxol hydrochloride and the like, the medicinal components are single, the medicinal components are often used in a combined way, and side effects on cardiovascular systems and the like of human bodies can be caused, and if the medicinal components are improperly used, fatal risks can be caused. And western medicines are mostly used for relieving the cold surface symptoms, namely treating the symptoms without treating the root cause, have single components, and cannot well solve a plurality of main complaints of patients.
Although there are few traditional Chinese medicines for treating cough and asthma in the market, because of different properties of compatible medicinal components, the object treated by each traditional Chinese medicine is also a certain type of cold, which is represented by loquat dew, lung-moistening cream, pummelo peel cream, suhuang cough and cough, and the like, and most of the traditional Chinese medicines are mainly used for treating wind-heat or wind-cold type cough.
"Huangdi's interior channel, su, ke Lun" cloud: cough with cough in both viscera and lung, but not in the sole lung.
Patients with cough and visit have symptoms mainly caused by deficiency of liver-yin and lung-yin and deficiency of stomach-yin, and mainly caused by sweating, thirst, cough, dyspnea, yellowish phlegm, poor appetite and irritability. In Ma xing Shi Gan Tang from Shang Han Lun, lung cough is mainly caused by excessive cough and deficiency syndrome is not middle energizer, and Ma Huang is contraindicated for deficiency sweat. The cough relieving and phlegm reducing Chinese patent medicines on the market at present have no good solution, such as fritillary and loquat leaf extract, and have the effects of reducing phlegm, relieving cough and nourishing yin, but the curative effect on yin deficiency and cough caused by yin deficiency of liver and lung is poor because the medicine efficacy of the Chinese patent medicine is not as good as that of liver and stomach.
In addition, most of traditional Chinese medicines are decocted with water, but partial active substances in traditional Chinese medicine plants have low solubility in water, so that the traditional Chinese medicines have the problems of small effect, long recovery time and the like when the traditional Chinese medicines exert the efficacy.
Disclosure of Invention
The invention aims to provide a cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by liver-lung yin deficiency, which is used for treating cough caused by liver-lung yin deficiency by using a combination of four traditional Chinese medicines including fritillaria cirrhosa, cassia twig, schisandra chinensis and paeonia lactiflora. The Chinese herbaceous peony and fritillary bulb are used for benefiting the yin of the liver and the lung, the cassia twig is used for dispelling exterior and eliminating cold evil, the schisandra fruit is used for astringing the yin of the lung, and the fritillary bulb and the cassia twig are used for promoting blood circulation and regulating the liver and the lung. The beta-cyclodextrin and its modified derivative are used to assist in extracting active components in the composite traditional Chinese medicine, and the hydroxyl group and glycosidic ether bond contained in the beta-cyclodextrin and its modified derivative can interact with the acceptor and donor of hydrogen bond, and the hydrophobic interaction of the beta-cyclodextrin and its modified derivative can load traditional Chinese medicine active substances with poor water solubility, so that the extraction efficiency of bioactive components is improved, the medicine effect is improved, the time required for rehabilitation is reduced, and the composite traditional Chinese medicine has the characteristics of strong specificity, good medicine effect and no side effect.
The invention aims to solve the technical problems:
the invention solves the problems that the traditional Chinese medicine prescription has poor curative effect when treating cough, expectoration and asthma caused by deficiency of liver-lung yin or deficiency of stomach-yin of a patient, and the existing traditional Chinese medicine prescription aims at the blank cough and asthma caused by deficiency of liver-lung yin and has smaller water solubility of active substances in the traditional Chinese medicine, so that the abundance of the active substances in the traditional Chinese medicine prescription is low.
The aim of the invention can be achieved by the following technical scheme:
a traditional Chinese medicine for treating cough and resolving phlegm caused by liver-lung yin deficiency comprises the following components:
4-8 parts of fritillaria cirrhosa, 1-5 parts of cassia twig, 1-3 parts of schisandra chinensis, 1-3 parts of paeonia lactiflora and 7-95 parts of auxiliary materials.
A traditional Chinese medicine for treating cough caused by liver-lung yin deficiency with cough relieving and phlegm resolving functions, the preparation method comprises the following steps:
s1, washing the traditional Chinese medicine materials with deionized water for 3 times, cutting into blocks, sun-drying, then crushing into coarse powder, sieving with a 80-mesh sieve to obtain composite traditional Chinese medicine powder, and storing at 4 ℃ for later use;
s2, soaking the composite traditional Chinese medicine powder in deionized water at room temperature for 1 hour, then adding auxiliary materials, stirring at a speed of 30rpm until the mixture is uniform, and performing condensation reflux operation to obtain an aqueous extract of the composite traditional Chinese medicine;
s3, spray drying the composite traditional Chinese medicine aqueous extract, wherein the temperature of an inlet is set to 80 ℃, the temperature of an outlet is set to 40 ℃, collecting dry powder, and preparing pills to obtain the cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by yin deficiency of liver and lung.
Further, in the step S2, the mass ratio of the composite traditional Chinese medicine powder to the deionized water is (75-80): 800, the condensation reflux time was 2 hours.
Further, the auxiliary material is one or more of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and hydroxypropyl-beta-cyclodextrin.
Further, the hydroxypropyl-beta-cyclodextrin is prepared by the steps of:
stirring NaOH solution at 30rpm, heating to 60 ℃, adding beta-cyclodextrin while keeping stirring, continuing stirring until the beta-cyclodextrin is completely dissolved, cooling the system to room temperature, then dropwise adding propylene oxide while stirring under ice bath, reacting for 3 hours, heating to room temperature, continuing stirring until an oil layer disappears, regulating the pH value of the system to 6-7 by using HCl solution, then distilling the mixed solution at 45 ℃ under reduced pressure to obtain slurry, dissolving the slurry by using 95% ethanol solution, continuing stirring for 30 minutes, filtering, discarding the precipitate, distilling the filtrate at 45 ℃ under reduced pressure until the volume is 1/3 of the volume, dialyzing with water for 3 hours, then standing at 45 ℃ again under reduced pressure, washing the obtained concentrated slurry by acetone, and drying to obtain the hydroxypropyl-beta-cyclodextrin.
The invention has the beneficial effects that:
(1) In the technical scheme of the invention, the combination of four traditional Chinese medicines including fritillaria cirrhosa, cassia twig, schisandra chinensis and paeonia lactiflora is used for treating cough caused by yin deficiency of liver and lung. According to the theory of traditional Chinese medicine, yin herbs are heavy in property, so that the gram number is increased, and the volume is the same as that of yang herbs. Regulating the dosage of the medicine, increasing the dosage of the fritillary bulb, and treating yin with yang (even) and treating yin with yang (odd). The Chinese herbaceous peony and fritillary bulb are used for benefiting the yin of the liver and the lung, the cassia twig is used for dispelling exterior and eliminating cold evil, the schisandra fruit is used for astringing the yin of the lung, and the fritillary bulb and the cassia twig are used for promoting blood circulation and regulating the liver and the lung. Cough with sputum due to yin deficiency caused by the season throttled influenza can be eradicated within 3 days, and all complications caused by seasonal influenza such as: the symptoms of liver-lung yin deficiency related to thirst, sweat, nasal discharge, sneeze, light yellow phlegm, deficiency asthma, and frequent sighing can also disappear, and the traditional Chinese medicine has good treatment effect.
(2) In the technical scheme of the invention, the beta-cyclodextrin and the modified derivative thereof are used for assisting in extracting active ingredients in the compound traditional Chinese medicine, the cyclodextrin has the characteristic of improving the solubility, bioavailability and stability of guest molecules by forming inclusion complex, all the ingredients are natural ingredients, no hormone ingredients are contained, the active ingredients are easier to be absorbed by human bodies, no toxic or side effect is caused on the human bodies, the stability and the moisture-proof capacity of the medicine storage are improved, and the curative effect is remarkable.
(3) In the technical scheme of the invention, the hydroxyl group and the glycosidic ether bond contained on the beta-cyclodextrin and the modified derivative thereof can interact with an acceptor and a donor of a hydrogen bond, and the beta-cyclodextrin and the modified derivative thereof have hydrophobic interaction, so that the beta-cyclodextrin and the modified derivative thereof load traditional Chinese medicine active substances with poor water solubility, the extraction efficiency of bioactive components is improved, the drug effect is improved, and the time required for rehabilitation is reduced.
(4) In the technical scheme of the invention, common traditional Chinese medicine combinations are adopted, less kinds of collocations are used, the medicine property of the traditional Chinese medicines is reasonably utilized, the applicable population is increased, and the possible side effect risk is reduced. The common cough traditional Chinese medicines such as ephedra herb and liquorice are not suitable for patients with excessive phlegm, phlegm dampness, large sweat or hemorrhagic diseases, so that the treatment effect of the medicine is different from person to person. Compared with all the existing cold medicines, the formula in the technical scheme not only can treat all complications caused by seasonal influenza viruses in a short period, but also can not cause burden to human kidneys, and has the characteristics of safety and effectiveness.
Detailed Description
The technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are only some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Example 1
A traditional Chinese medicine for treating cough and resolving phlegm caused by liver-lung yin deficiency comprises the following components:
40g of fritillaria cirrhosa, 10g of cassia twig, 10g of schisandra chinensis, 10g of paeonia lactiflora and 8g of beta-cyclodextrin.
A traditional Chinese medicine for treating cough caused by liver-lung yin deficiency with cough relieving and phlegm resolving functions, the preparation method comprises the following steps:
s1, washing fritillary bulb, cassia twig, shizandra berry and Chinese herbaceous peony traditional Chinese medicine materials with deionized water for 3 times, cutting into blocks, sun-drying, then crushing into coarse powder, sieving with a 80-mesh sieve, mixing according to the formula parts by weight, obtaining composite traditional Chinese medicine powder, and storing at 4 ℃ for later use;
s2, soaking 70g of the composite traditional Chinese medicine powder in 800mL of deionized water at room temperature for 1 hour, then adding beta-cyclodextrin, stirring at a speed of 30rpm until the mixture is uniform, and performing condensation reflux operation to obtain an aqueous extract of the composite traditional Chinese medicine;
s3, spray drying the composite traditional Chinese medicine aqueous extract, wherein the temperature of an inlet is set to 80 ℃, the temperature of an outlet is set to 40 ℃, collecting dry powder, and preparing pills to obtain the cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by yin deficiency of liver and lung.
Example 2
A traditional Chinese medicine for treating cough and resolving phlegm caused by liver-lung yin deficiency comprises the following components:
30g of fritillaria cirrhosa, 15g of cassia twig, 10g of schisandra chinensis, 10g of paeonia lactiflora and 20g of beta-cyclodextrin.
A traditional Chinese medicine for treating cough caused by liver-lung yin deficiency with cough relieving and phlegm resolving functions, the preparation method comprises the following steps:
s1, washing fritillary bulb, cassia twig, shizandra berry and Chinese herbaceous peony traditional Chinese medicine materials with deionized water for 3 times, cutting into blocks, sun-drying, then crushing into coarse powder, sieving with a 80-mesh sieve, mixing according to the formula parts by weight, obtaining composite traditional Chinese medicine powder, and storing at 4 ℃ for later use;
s2, soaking 65g of the composite traditional Chinese medicine powder in 800mL of deionized water at room temperature for 1 hour, then adding 20g of beta-cyclodextrin, stirring at a speed of 30rpm until the mixture is uniform, and performing condensation reflux operation to obtain an aqueous extract of the composite traditional Chinese medicine;
s3, spray drying the composite traditional Chinese medicine aqueous extract, wherein the temperature of an inlet is set to 80 ℃, the temperature of an outlet is set to 40 ℃, collecting dry powder, and preparing pills to obtain the cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by yin deficiency of liver and lung.
Example 3
A traditional Chinese medicine for treating cough and resolving phlegm caused by liver-lung yin deficiency comprises the following components:
32g of fritillaria cirrhosa, 20g of cassia twig, 12g of schisandra chinensis, 12g of paeonia lactiflora and 40g of hydroxypropyl-beta-cyclodextrin.
A traditional Chinese medicine for treating cough caused by liver-lung yin deficiency with cough relieving and phlegm resolving functions, the preparation method comprises the following steps:
s1, washing fritillary bulb, cassia twig, shizandra berry and Chinese herbaceous peony traditional Chinese medicine materials with deionized water for 3 times, cutting into blocks, sun-drying, then crushing into coarse powder, sieving with a 80-mesh sieve, mixing according to the formula parts by weight, obtaining composite traditional Chinese medicine powder, and storing at 4 ℃ for later use;
s2, stirring 14.1g of NaOH solution at a speed of 30rpm, heating to 60 ℃, adding 20g of beta-cyclodextrin under the condition of keeping stirring, continuing stirring until the beta-cyclodextrin is completely dissolved, cooling the system to room temperature, then dropwise adding 15.2g of propylene oxide under ice bath while stirring, reacting for 3 hours, heating to room temperature, continuing stirring until an oil layer disappears, adjusting the pH value of the system to 6.8 by using HC (hydrogen carbonate) solution, then distilling the mixed solution under reduced pressure at 45 ℃ to obtain slurry, dissolving the slurry by using 95% ethanol solution, continuing stirring for 30 minutes, filtering, discarding the precipitate, distilling the filtrate under reduced pressure at 45 ℃ until the volume is 1/3 of the original volume, dialyzing the filtrate with water for 3 hours, then standing at 45 ℃ again under reduced pressure, washing the obtained concentrated slurry by acetone, and drying to obtain the hydroxypropyl-beta-cyclodextrin.
S3, soaking 76g of the composite traditional Chinese medicine powder in 800mL of deionized water at room temperature for 1 hour, then adding 40g of hydroxypropyl-beta-cyclodextrin, stirring at a speed of 30rpm until the mixture is uniform, and performing condensation reflux operation to obtain an aqueous extract of the composite traditional Chinese medicine;
s4, spray drying the composite traditional Chinese medicine aqueous extract, wherein the temperature of an inlet is set to 80 ℃, the temperature of an outlet is set to 40 ℃, collecting dry powder, and preparing pills to obtain the cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by yin deficiency of liver and lung.
Example 4
The comparative example differs from example 2 in that the adjuvant used in this example is alpha-cyclodextrin.
Comparative example 1
A traditional Chinese medicine for treating cough and resolving phlegm caused by liver-lung yin deficiency comprises the following components:
30g of fritillaria cirrhosa, 15g of cassia twig, 10g of schisandra chinensis and 10g of paeonia lactiflora.
A preparation method of a traditional Chinese medicine for treating cough and reducing sputum caused by liver-lung yin deficiency comprises the following steps: s1, washing fritillary bulb, cassia twig, shizandra berry and Chinese herbaceous peony traditional Chinese medicine materials with deionized water for 3 times, cutting into blocks, sun-drying, then crushing into coarse powder, sieving with a 80-mesh sieve, mixing according to the formula parts by weight, obtaining composite traditional Chinese medicine powder, and storing at 4 ℃ for later use;
s2, soaking 65g of the composite traditional Chinese medicine powder in 800mL of deionized water at room temperature for 1 hour, and then performing condensation reflux operation to obtain an aqueous extract of the composite traditional Chinese medicine;
s3, spray drying the composite traditional Chinese medicine aqueous extract, wherein the temperature of an inlet is set to 80 ℃, the temperature of an outlet is set to 40 ℃, collecting dry powder, and preparing pills to obtain the cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by yin deficiency of liver and lung.
Comparative example 2
A traditional Chinese medicine for treating cough and resolving phlegm caused by liver-lung yin deficiency comprises the following components:
30g of fritillaria cirrhosa, 15g of cassia twig, 10g of schisandra chinensis and 10g of paeonia lactiflora.
A preparation method of a traditional Chinese medicine for treating cough and reducing sputum caused by liver-lung yin deficiency comprises the following steps:
s1, washing fritillary bulb, cassia twig, shizandra berry and Chinese herbaceous peony traditional Chinese medicine materials with deionized water for 3 times, cutting into blocks, sun-drying, and mixing according to the formula parts by weight to obtain a composite traditional Chinese medicine;
s2, adding 800g of water into the compound traditional Chinese medicine, boiling and boiling for 0.5h, adding 700g of water, boiling and boiling for 0.5h, filtering, and collecting filtrate to obtain the cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by liver-lung yin deficiency.
The pharmacological effects of the agents prepared in examples 1-4 and comparative examples 1-2 were now examined.
1. And selecting a case.
Cough patients caused by liver-lung yin deficiency or stomach-yin deficiency are selected, and the clinical manifestations are mainly cough asthma, emaciation, dry throat, dry cough, little phlegm, bloody sputum, hoarseness, afternoon hot flashes, cheekbone red, dysphoria with feverish sensation in the chest, night sweat, red tongue with little coating, thin and rapid pulse and other symptoms, and the cough patients can be seen as hoarseness, dry cough, no phlegm or difficult expectoration with little phlegm, and also have symptoms of asthma, dry mouth, insomnia, irritability, crying and sighing and the like.
2. Efficacy verification and observation
300 patients without severe malnutrition, without other cardiovascular diseases, liver, kidney and hematopoietic systems, without serious systemic diseases and drug allergy history and distributed in all age groups are selected for administration, and taken twice a day for two days. And judging the curative effect of the medicine according to the symptom change of the patient. Wherein, the cure standard is: symptoms such as thirst, sweat, cough, expectoration, asthma and the like disappear, the body temperature is normal, and various indexes are normal; the standard with obvious effect is: the symptoms such as thirst, sweat, cough, expectoration, asthma and the like are mostly disappeared, and the abnormal physicochemical indexes are close to normal; the standard with certain effect is: symptoms such as thirst, sweat, cough, expectoration, asthma and the like are partially disappeared, and abnormal physicochemical indexes are improved; the criteria for invalidation were: not meeting the above criteria.
The test results are shown in table 1 below:
TABLE 1 detection of efficacy of the pharmaceutical agents prepared in examples 1-4 and comparative examples 1-2
Out of 300 cases, 174 were in men and 126 in women. As can be seen from the results in Table 1, the cure rate of both men and women is over 95% after two days of administration in the four examples, and as can be seen from the data in comparative examples 1 and 2, the use of the beta-cyclodextrin and its modified derivatives for auxiliary extraction is beneficial to the complete utilization of active substances in the traditional Chinese medicine, beneficial to the pharmacodynamic action and reduction of cure time.
In the description of the present specification, the descriptions of the terms "one embodiment," "example," "specific example," and the like, mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing is merely illustrative and explanatory of the invention, as various modifications and additions may be made to the particular embodiments described, or in a similar manner, by those skilled in the art, without departing from the scope of the invention or exceeding the scope of the invention as defined in the claims.

Claims (5)

1. A traditional Chinese medicine for treating cough and reducing sputum caused by liver-lung yin deficiency is characterized by comprising the following raw materials in parts by mass:
4-8 parts of fritillaria cirrhosa, 1-5 parts of cassia twig, 1-3 parts of schisandra chinensis, 1-3 parts of paeonia lactiflora and 7-95 parts of auxiliary materials.
2. The cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by yin deficiency of liver and lung according to claim 1, wherein the preparation method comprises the following steps:
s1, washing the traditional Chinese medicine materials with deionized water for 3 times, cutting into blocks, sun-drying, then crushing into coarse powder, sieving with a 80-mesh sieve to obtain composite traditional Chinese medicine powder, and storing at 4 ℃ for later use;
s2, soaking the composite traditional Chinese medicine powder in deionized water at room temperature for 1 hour, then adding auxiliary materials, stirring at a speed of 30rpm until the mixture is uniform, and performing condensation reflux operation to obtain an aqueous extract of the composite traditional Chinese medicine;
s3, spray drying the composite traditional Chinese medicine aqueous extract, wherein the temperature of an inlet is set to 80 ℃, the temperature of an outlet is set to 40 ℃, collecting dry powder, and preparing pills to obtain the cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by yin deficiency of liver and lung.
3. The traditional Chinese medicine for treating cough and phlegm caused by liver-lung yin deficiency according to claim 2, wherein in the step S2, the mass ratio of the composite traditional Chinese medicine powder to deionized water is (75-80): 800, the condensation reflux time was 2 hours.
4. The traditional Chinese medicine for treating cough and phlegm caused by yin deficiency of liver and lung according to claim 1, wherein the auxiliary materials are one or more of alpha-cyclodextrin, beta-cyclodextrin, gamma-cyclodextrin and hydroxypropyl-beta-cyclodextrin.
5. The cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by yin deficiency of liver and lung according to claim 4, wherein the hydroxypropyl-beta-cyclodextrin is prepared by the following steps:
stirring NaOH solution at 30rpm, heating to 60 ℃, adding beta-cyclodextrin while keeping stirring, continuing stirring until the beta-cyclodextrin is completely dissolved, cooling the system to room temperature, then dropwise adding propylene oxide while stirring under ice bath, reacting for 3 hours, heating to room temperature, continuing stirring until an oil layer disappears, regulating the pH value of the system to 6-7 by using HCl solution, then distilling the mixed solution at 45 ℃ under reduced pressure to obtain slurry, dissolving the slurry by using 95% ethanol solution, continuing stirring for 30 minutes, filtering, discarding the precipitate, distilling the filtrate at 45 ℃ under reduced pressure until the volume is 1/3 of the volume, dialyzing with water for 3 hours, then standing at 45 ℃ again under reduced pressure, washing the obtained concentrated slurry by acetone, and drying to obtain the hydroxypropyl-beta-cyclodextrin.
CN202310497253.3A 2023-05-05 2023-05-05 Cough relieving and phlegm reducing traditional Chinese medicine for treating cough caused by liver-lung yin deficiency Pending CN116549555A (en)

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