CN1165320C - Externally applied medicine for treating cervical erosion and its prepn - Google Patents
Externally applied medicine for treating cervical erosion and its prepn Download PDFInfo
- Publication number
- CN1165320C CN1165320C CNB011087773A CN01108777A CN1165320C CN 1165320 C CN1165320 C CN 1165320C CN B011087773 A CNB011087773 A CN B011087773A CN 01108777 A CN01108777 A CN 01108777A CN 1165320 C CN1165320 C CN 1165320C
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- CN
- China
- Prior art keywords
- medicine
- radix
- cervical erosion
- gram
- mesh sieves
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000003814 drug Substances 0.000 title claims abstract description 36
- 230000003628 erosive effect Effects 0.000 title claims abstract description 19
- 229940079593 drug Drugs 0.000 claims abstract description 11
- 239000000843 powder Substances 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000011265 semifinished product Substances 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000002994 raw material Substances 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 230000029087 digestion Effects 0.000 claims description 3
- 239000012535 impurity Substances 0.000 claims description 3
- 239000012528 membrane Substances 0.000 claims description 3
- -1 patch Substances 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 6
- 210000000981 epithelium Anatomy 0.000 abstract description 3
- 238000002474 experimental method Methods 0.000 abstract description 3
- 230000035876 healing Effects 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 230000036592 analgesia Effects 0.000 abstract description 2
- 210000001215 vagina Anatomy 0.000 abstract description 2
- 238000012795 verification Methods 0.000 abstract description 2
- 238000001035 drying Methods 0.000 abstract 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 abstract 1
- 241000130781 Arnebia Species 0.000 abstract 1
- 241001313857 Bletilla striata Species 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000003251 Pruritus Diseases 0.000 abstract 1
- 244000153955 Reynoutria sachalinensis Species 0.000 abstract 1
- 235000003202 Reynoutria sachalinensis Nutrition 0.000 abstract 1
- 206010039509 Scab Diseases 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000007803 itching Effects 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 239000008213 purified water Substances 0.000 abstract 1
- 231100000820 toxicity test Toxicity 0.000 abstract 1
- 206010020880 Hypertrophy Diseases 0.000 description 3
- 206010008323 cervicitis Diseases 0.000 description 3
- 210000003679 cervix uteri Anatomy 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 201000010380 endocervicitis Diseases 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 241001523383 Achnatherum Species 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 208000006374 Uterine Cervicitis Diseases 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention discloses externally-used medicine for treating cervical erosion and a preparation method thereof. The medicine is prepared from giant knotweed rhizome, sinkiang arnebia root, lightyellow sophora root, parslane herb, tuber of hyacinth bletilla and borneol by means of the following procedures comprising drying, grinding into powder, decocting the powder in purified water, concentrating, drying and crushing. When the medicine of the present invention is used in medical treatment, the medicine is directly used on a wound surface, and the medicine which has a simple formula has special effects. In the healing of cervical erosion, columnar epithelium is replaced by squamous epithelium. Clinical verification shows that curative effects are obvious. Experiments on medicine effects show that the medicine of the present invention has the functions of inflammation resistance, itching relief, analgesia, scab and healing promotion for skin. Toxicity experiments in the forms of oral taking and vagina medication show that the present invention is safe and has no toxicity.
Description
Technical field: the present invention relates to a kind of external used medicine and preparation method, be specifically related to a kind of treatment cervical erosion external used medicine and preparation method.
Background technology: cervical erosion is a kind of common of married woman, frequently-occurring disease, this disease of treatment mainly adopts laser and local administration method at present, but laser and ripple nurse light are in treatment cervical erosion process, cervix uteri surface secretions is increased, repair slowly, vaginal secretions increases, cervical hypertrophy is difficult for dwindling, and be used for this sick common drug at present as the cervix uteri health, difficult to understand flat, elegant, refined object for enjoyment cervicitis, control medicines such as Mi Lingshuan, though certain therapeutical effect, DeGrain are arranged, reparation to the cervical erosion face is also incomplete, and costing an arm and a leg of having, also often recurrence can not be effected a radical cure after the medication.
Summary of the invention: the objective of the invention is to: a kind of heat-clearing and toxic substances removing is provided, the dampness dampness removing, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting, and also curative effect is obvious, is difficult for the treatment cervical erosion external used medicine and the preparation method of recurrence.
The present invention is achieved in that it is by the formulated medicament of following materials of weight proportions: Rhizoma Polygoni Cuspidati 10---30 grams, Radix Arnebiae (Radix Lithospermi) 10---20 grams, Radix Sophorae Flavescentis 10---30 grams, Herba Portulacae 10---30 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 7---15 gram, Borneolum Syntheticum 5---10 grams, its making step is: A, respectively Rhizoma Polygoni Cuspidati, Radix Arnebiae (Radix Lithospermi), Radix Sophorae Flavescentis, Herba Portulacae, the Pseudobulbus Bletillae (Rhizoma Bletillae) are screened, wash profit, remove impurity, section, oven dry is clayed into power respectively; B, respectively to raw material medicated powder Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Herba Portulacae pure water digestion through 80 ℃, concentrate down at 100 ℃ then, vacuum drying is pulverized, and crosses 120 mesh sieves, semi-finished product Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Herba Portulacae; C, Pseudobulbus Bletillae (Rhizoma Bletillae) crude drug powder is crossed 60 mesh sieves, Radix Arnebiae (Radix Lithospermi) raw material medicated powder is crossed 120 mesh sieves, the semi-finished product Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi); D, B, C gained semi-finished product medicated powder are filtered, mix, add Borneolum Syntheticum, add 50% ethanol, 120 mesh sieves of granulating, 120 ℃ dry down, 120 mesh sieves of granulating, mixing, fill, this medicine for external use can be made into capsule, patch, membrane, suppository.
The present invention compared with prior art has following advantage:
1, the present invention fills a prescription rationally, main heat-clearing and toxic substances removing, dampness dampness removing, blood circulation promoting and blood stasis dispelling, putrefaction-removing granulation-promoting;
2, Drug therapy cervical erosion of the present invention, endocervicitis, cervical hypertrophy are evident in efficacy, treat 2000 many cases, follow up a case by regular visits to 697 examples, after the vagina surface medication 3 times, leucorrhea significantly reduces, and the cervical erosion face is entad type reparation, cervical erosion companion cervical hypertrophy, after the recovery from illness, loose cervix uteri dwindles 0.5---0.9cm;
3, medicine of the present invention is in treatment, the wound surface direct drug injection, and medicine letter power is special, and squamous epithelial cancer in the agglutination of cervical erosion has replaced columnar epithelium, clinical verification, curative effect is conclusive;
4, medicine of the present invention is through effect experiment, has antiinflammatory, antipruritic, analgesia, promotes skin incrustation healing, and oral and Yin Dao Give poison of drug experiment shows safety non-toxic.
The specific embodiment:
The embodiment of the invention: get Chinese medicine Rhizoma Polygoni Cuspidati 15 grams respectively, Radix Arnebiae (Radix Lithospermi) 12 grams, Radix Sophorae Flavescentis 15 grams, Herba Portulacae 15 grams, the Pseudobulbus Bletillae (Rhizoma Bletillae) 10 grams, screening, remove impurity, wash profit, remove earth and foreign body, respectively above five kinds of crude drug are cut into slices, all be cut into the small pieces about 2cm, oven dry is clayed into power respectively, to raw material medicated powder Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Herba Portulacae is respectively through 80 ℃ pure water digestion, concentrate down at 100 ℃ then, get fluid extract, vacuum drying is pulverized again, cross 120 mesh sieves, get the semi-finished product Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Herba Portulacae, crude drug whitewash splendid achnatherum is crossed 60 mesh sieves, and Radix Arnebiae (Radix Lithospermi) crosses 120 mesh sieves, get the semi-finished product Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi), with the semi-finished product Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Herba Portulacae, the Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi) is filtered, and mixes, and adds 7 gram Borneolum Syntheticums, add 50% ethanol, 120 mesh sieves of granulating, dry under 120 ℃, granulate is crossed 120 mesh sieves, mixing, fill promptly makes the external used medicine for the treatment of cervical erosion.This medicine for external use can be made into capsule, patch, membrane, suppository.
This medicine for external use is for 10 times a course of treatment to slight cervical erosion; Moderate cervical erosion is for 20 times a course of treatment; Moderate and severe cervical and endocervicitis are for 30 times a course of treatment; Can cure a general course of treatment.
Claims (3)
1, a kind of treatment cervical erosion external used medicine is characterized in that it is formulated by following materials of weight proportions: Rhizoma Polygoni Cuspidati 10-30 gram, Radix Arnebiae (Radix Lithospermi) 10-20 gram, Radix Sophorae Flavescentis 10-30 gram, Herba Portulacae 10-30 gram, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-15 gram, Borneolum Syntheticum 5-10 gram.
2, according to a kind of preparation method for the treatment of the cervical erosion external used medicine of claim 1, it is characterized in that: its making step is A, respectively Rhizoma Polygoni Cuspidati, Radix Arnebiae (Radix Lithospermi), Radix Sophorae Flavescentis, Herba Portulacae, the Pseudobulbus Bletillae (Rhizoma Bletillae) is screened, and washes profit, remove impurity, section, oven dry is clayed into power respectively; B, respectively to raw material medicated powder Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Herba Portulacae pure water digestion through 80 ℃, concentrate down at 100 ℃ then, vacuum drying is pulverized, and crosses 120 mesh sieves, semi-finished product Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Herba Portulacae; C, Pseudobulbus Bletillae (Rhizoma Bletillae) crude drug powder is crossed 60 mesh sieves, Radix Arnebiae (Radix Lithospermi) raw material medicated powder is crossed 120 mesh sieves, the semi-finished product Pseudobulbus Bletillae (Rhizoma Bletillae), Radix Arnebiae (Radix Lithospermi); D, B, C gained semi-finished product medicated powder are filtered, mix, add Borneolum Syntheticum, add 50% ethanol, 120 mesh sieves of granulating, 120 ℃ dry down, 120 mesh sieves of granulating, mixing, fill.
3, a kind of preparation method for the treatment of the cervical erosion external used medicine according to claim 2, it is characterized in that: this medicine for external use is made capsule, patch, membrane, suppository.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011087773A CN1165320C (en) | 2001-08-21 | 2001-08-21 | Externally applied medicine for treating cervical erosion and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011087773A CN1165320C (en) | 2001-08-21 | 2001-08-21 | Externally applied medicine for treating cervical erosion and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1348782A CN1348782A (en) | 2002-05-15 |
| CN1165320C true CN1165320C (en) | 2004-09-08 |
Family
ID=4657568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011087773A Expired - Fee Related CN1165320C (en) | 2001-08-21 | 2001-08-21 | Externally applied medicine for treating cervical erosion and its prepn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1165320C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028873B (en) * | 2010-11-30 | 2011-12-21 | 甘肃陇神药物研究院 | Tannin berberine gel for treating cervical erosion and preparation process thereof |
| CN104784325A (en) * | 2014-05-15 | 2015-07-22 | 刘善奎 | Traditional Chinese medicine suppository for treating cervical erosion |
| CN117717586A (en) * | 2023-12-04 | 2024-03-19 | 广州众乐国际生物科技有限公司 | Biological agent for auxiliary treatment of cervical erosion and preparation method thereof |
-
2001
- 2001-08-21 CN CNB011087773A patent/CN1165320C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1348782A (en) | 2002-05-15 |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |