CN116510021A - 有限化慢性乙肝的核苷(酸)类药物治疗的药物及方法 - Google Patents

有限化慢性乙肝的核苷(酸)类药物治疗的药物及方法 Download PDF

Info

Publication number
CN116510021A
CN116510021A CN202210079582.1A CN202210079582A CN116510021A CN 116510021 A CN116510021 A CN 116510021A CN 202210079582 A CN202210079582 A CN 202210079582A CN 116510021 A CN116510021 A CN 116510021A
Authority
CN
China
Prior art keywords
hbv
region
amino acid
pro
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202210079582.1A
Other languages
English (en)
Chinese (zh)
Inventor
刘宏利
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Hep Pharmaceutical Co ltd
Original Assignee
Shanghai Hep Pharmaceutical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai Hep Pharmaceutical Co ltd filed Critical Shanghai Hep Pharmaceutical Co ltd
Priority to CN202210079582.1A priority Critical patent/CN116510021A/zh
Priority to JP2024543941A priority patent/JP2025503152A/ja
Priority to PCT/CN2023/076223 priority patent/WO2023138696A1/zh
Priority to EP23743010.3A priority patent/EP4470564A4/en
Priority to US18/832,497 priority patent/US20250161335A1/en
Priority to CN202380018193.0A priority patent/CN118574640A/zh
Publication of CN116510021A publication Critical patent/CN116510021A/zh
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/675Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • A61K31/522Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/66Phosphorus compounds
    • A61K31/683Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/21Interferons [IFN]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202210079582.1A 2022-01-24 2022-01-24 有限化慢性乙肝的核苷(酸)类药物治疗的药物及方法 Pending CN116510021A (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN202210079582.1A CN116510021A (zh) 2022-01-24 2022-01-24 有限化慢性乙肝的核苷(酸)类药物治疗的药物及方法
JP2024543941A JP2025503152A (ja) 2022-01-24 2023-02-15 慢性b型肝炎のヌクレオシド(ヌクレオチド)類薬物の治療を有限化する薬物及び方法
PCT/CN2023/076223 WO2023138696A1 (zh) 2022-01-24 2023-02-15 有限化慢性乙肝的核苷(酸)类药物治疗的药物及方法
EP23743010.3A EP4470564A4 (en) 2022-01-24 2023-02-15 NUCLEOSIDE (ACID)-BASED DRUG AND METHOD FOR DRUG THERAPY FOR LIMITING CHRONIC HEPATITIS B
US18/832,497 US20250161335A1 (en) 2022-01-24 2023-02-15 Drug and Method for Nucleoside (Acid) Drug Therapy of Limiting Chronic Hepatitis B
CN202380018193.0A CN118574640A (zh) 2022-01-24 2023-02-15 有限化慢性乙肝的核苷(酸)类药物治疗的药物及方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210079582.1A CN116510021A (zh) 2022-01-24 2022-01-24 有限化慢性乙肝的核苷(酸)类药物治疗的药物及方法

Publications (1)

Publication Number Publication Date
CN116510021A true CN116510021A (zh) 2023-08-01

Family

ID=87347912

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202210079582.1A Pending CN116510021A (zh) 2022-01-24 2022-01-24 有限化慢性乙肝的核苷(酸)类药物治疗的药物及方法
CN202380018193.0A Pending CN118574640A (zh) 2022-01-24 2023-02-15 有限化慢性乙肝的核苷(酸)类药物治疗的药物及方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202380018193.0A Pending CN118574640A (zh) 2022-01-24 2023-02-15 有限化慢性乙肝的核苷(酸)类药物治疗的药物及方法

Country Status (5)

Country Link
US (1) US20250161335A1 (https=)
EP (1) EP4470564A4 (https=)
JP (1) JP2025503152A (https=)
CN (2) CN116510021A (https=)
WO (1) WO2023138696A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025087290A1 (zh) * 2023-10-27 2025-05-01 苏州瑞博生物技术股份有限公司 一种药物组合物及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102675430B (zh) * 2005-08-12 2014-08-27 上海贺普药业股份有限公司 乙型肝炎病毒表面l蛋白相关肽
WO2009092396A1 (en) * 2008-01-25 2009-07-30 Universitätsklinikum Heidelberg Hydrophobic modified pres-derived peptides of hepatitis b virus (hbv) and their use as hbv and hdv entry inhibitors
CN107106686B (zh) * 2014-10-07 2022-09-27 Myr有限公司 Hbv和hdv感染的联合治疗
CN109718364A (zh) * 2017-10-27 2019-05-07 上海贺普药业股份有限公司 充分剂量条件下治疗乙肝病毒相关肝病的药物和方法
CN114828852A (zh) * 2019-12-24 2022-07-29 豪夫迈·罗氏有限公司 用于治疗hbv的靶向hbv的抗病毒药剂和/或免疫调节剂的药物组合
EP3865489A1 (en) * 2020-02-11 2021-08-18 Promidis S.r.l. Spirocyclic inhibitors of hepatitis b virus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025087290A1 (zh) * 2023-10-27 2025-05-01 苏州瑞博生物技术股份有限公司 一种药物组合物及其用途

Also Published As

Publication number Publication date
EP4470564A1 (en) 2024-12-04
JP2025503152A (ja) 2025-01-30
US20250161335A1 (en) 2025-05-22
EP4470564A4 (en) 2025-10-22
CN118574640A (zh) 2024-08-30
WO2023138696A1 (zh) 2023-07-27

Similar Documents

Publication Publication Date Title
CN102015753A (zh) 乙肝病毒(HBV)的疏水性修饰的preS-衍生肽及其作为载体将化合物特异性递送到肝脏的用途
KR20150110486A (ko) 생식샘자극 호르몬 카복시 말단 펩타이드들과 부착하여 폴리펩타이드들의 유체역학적 부피를 증가시키는 방법
EP3204030B1 (en) Combination therapy of hbv and hdv infection
JP7571008B2 (ja) インターフェロンラムダでのデルタ肝炎ウイルス感染処置
WO2019076331A1 (zh) 非酒精性脂肪性肝病的治疗药物
JP7672677B2 (ja) 全用量条件下でb型肝炎ウイルス関連肝疾患を治療する医薬品および方法
JP2018512428A5 (https=)
US20230211003A1 (en) Conjugate compounds for preventing and/or treating hbv and/or hdv infections, liver diseases andfor targeting ntcp
TW202011990A (zh) TACI-Fc融合蛋白用於製備治療視神經脊髓炎譜系疾病和多發性硬化之藥物中的應用
JP2023531682A (ja) D型肝炎ウイルス感染の処置のための組成物および方法
EP4470564A1 (en) Drug and method for nucleoside (acid) drug therapy of limiting chronic hepatitis b
TWI334785B (en) Use of recombinant ifn-β1a and pharmaceutical composition comprising recombinant ifn-β1a for the treatment of hcv infection in patients of asian race
WO2011140984A1 (zh) 抗hbv的多肽、其药物组合物及应用
Keating Peginterferon-α-2a (40 kD) A Review of its Use in Chronic Hepatitis B
NZ336954A (en) Soluble gp80 and/or gp130 receptor sites sufficient to inhibit the binding of hIL6 to hepatocytes and other HBV-permissive cells
Homs et al. HBV core region variability: effect of antiviral treatments on main epitopic regions
TW202515603A (zh) 慢性b型肝炎之評估與治療
KR102084912B1 (ko) B형 간염 바이러스 표면 항원의 입체 에피토프 및 이에 특이적으로 결합하는 항체
JPWO2023138696A5 (https=)
Chan et al. P. 121 Severe acute exacerbation of HBeAg-negative chronic hepatitis B has good maintained response to lamivudine treatment
Rodgers et al. P. 123 Characterisation of a mouse monoclonal and rabbit polyclonal antibody against the hepatitis B precore protein
HK1111092A (en) Treatment of hepatitis c in the asian population with interferon-beta

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination