CN116492513B - Wen Minla material for sow conception automatic vas deferens and preparation method thereof - Google Patents
Wen Minla material for sow conception automatic vas deferens and preparation method thereof Download PDFInfo
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- CN116492513B CN116492513B CN202310625856.7A CN202310625856A CN116492513B CN 116492513 B CN116492513 B CN 116492513B CN 202310625856 A CN202310625856 A CN 202310625856A CN 116492513 B CN116492513 B CN 116492513B
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- 239000000463 material Substances 0.000 title claims abstract description 99
- 241001157146 Minla Species 0.000 title claims abstract description 64
- 210000001177 vas deferen Anatomy 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- 235000013871 bee wax Nutrition 0.000 claims abstract description 53
- 239000012166 beeswax Substances 0.000 claims abstract description 45
- 239000011230 binding agent Substances 0.000 claims abstract description 45
- 239000000945 filler Substances 0.000 claims abstract description 41
- 239000000314 lubricant Substances 0.000 claims abstract description 39
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims abstract description 16
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims abstract description 16
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims abstract description 16
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000005642 Oleic acid Substances 0.000 claims abstract description 16
- 235000021314 Palmitic acid Nutrition 0.000 claims abstract description 16
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims abstract description 16
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims abstract description 16
- IPCSVZSSVZVIGE-UHFFFAOYSA-N n-hexadecanoic acid Natural products CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims abstract description 16
- 108010010803 Gelatin Proteins 0.000 claims abstract description 11
- 229920000159 gelatin Polymers 0.000 claims abstract description 11
- 239000008273 gelatin Substances 0.000 claims abstract description 11
- 235000019322 gelatine Nutrition 0.000 claims abstract description 11
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 11
- 239000011664 nicotinic acid Substances 0.000 claims abstract description 7
- 230000004720 fertilization Effects 0.000 claims abstract description 5
- 239000007787 solid Substances 0.000 claims abstract description 5
- 238000003756 stirring Methods 0.000 claims description 34
- 238000002844 melting Methods 0.000 claims description 19
- 230000008018 melting Effects 0.000 claims description 19
- 238000010438 heat treatment Methods 0.000 claims description 16
- 239000000203 mixture Substances 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 14
- 238000002156 mixing Methods 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 11
- 229940110456 cocoa butter Drugs 0.000 claims description 10
- 235000019868 cocoa butter Nutrition 0.000 claims description 10
- 238000001816 cooling Methods 0.000 claims description 7
- 238000007873 sieving Methods 0.000 claims description 6
- 238000005303 weighing Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000003814 drug Substances 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 23
- 239000001993 wax Substances 0.000 description 16
- 230000009027 insemination Effects 0.000 description 13
- 238000002347 injection Methods 0.000 description 11
- 239000007924 injection Substances 0.000 description 11
- 230000000903 blocking effect Effects 0.000 description 8
- 210000000582 semen Anatomy 0.000 description 8
- 230000036760 body temperature Effects 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- 239000002195 soluble material Substances 0.000 description 6
- 241000282887 Suidae Species 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000006978 adaptation Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
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- 238000010586 diagram Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 230000009931 harmful effect Effects 0.000 description 2
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- 238000006864 oxidative decomposition reaction Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011540 sensing material Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- QHZLMUACJMDIAE-UHFFFAOYSA-N 1-monopalmitoylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)CO QHZLMUACJMDIAE-UHFFFAOYSA-N 0.000 description 1
- RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
- 208000007407 African swine fever Diseases 0.000 description 1
- 241001391944 Commicarpus scandens Species 0.000 description 1
- 241000662429 Fenerbahce Species 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000001938 differential scanning calorimetry curve Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229940096898 glyceryl palmitate Drugs 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001746 injection moulding Methods 0.000 description 1
- 230000001050 lubricating effect Effects 0.000 description 1
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- 229930014626 natural product Natural products 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
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- 238000004088 simulation Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
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- 238000003860 storage Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D19/00—Instruments or methods for reproduction or fertilisation
- A61D19/02—Instruments or methods for reproduction or fertilisation for artificial insemination
- A61D19/027—Devices for injecting semen into animals, e.g. syringes, guns, probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/452—Lubricants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Husbandry (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
The utility model belongs to the field of bionic biotechnology, and particularly discloses a Wen Minla material for automatic seminiferous ducts for sow conception and a preparation method thereof. The Wen Minla material for the sow conception automatic seminiferous duct is prepared from the following components in percentage by weight: 61-69% of beeswax, 8-12% of binder, 12-18% of lubricant and the balance of filler. The binder is gelatin; the lubricant is composed of 3-5 mass ratio of oleic acid glyceride and palmitic acid glyceride: 1. In the utility model, beeswax, binder, lubricant and filler are melt blended according to a proper proportion, so that the stability is high and the plasticity is strong; the preparation process is simple, environment-friendly and safe. The utility model can be directly applied to organisms, and can prepare the medicine and the Wen Minla material into a solid preparation with a certain shape for the administration in the organism cavity; or can be matched with bionic biological instrument such as automatic vas deferens to make into part parts for improving organism fertilization. The utility model greatly saves the economic and time costs and is suitable for industrial popularization.
Description
Technical Field
The utility model relates to the field of bionic biotechnology, in particular to a Wen Minla material for automatic seminiferous ducts for sow conception and a preparation method thereof.
Background
Under the background of modern intensive culture and African swine fever, the artificial insemination has the advantages of improving the utilization rate of high-quality boars, reducing the raising amount of the boars, reducing the limitation of areas and time, reducing the spread of diseases and the like, and is widely used in large-scale pig farms.
The Chinese patent with the publication number of CN 217744696U discloses an automatic vas deferens device for pigs in 2022, 11 and 08, in particular to an automatic vas deferens, which comprises a vas deferens body and an injection pipe connected with the vas deferens body, one end of the injection pipe is fixedly connected with a safety helmet, a breakable part is arranged between the safety helmet and the injection pipe, a liquid injection cavity penetrating through two ends is arranged in the injection pipe, a first blocking layer is arranged in a cavity of the liquid injection cavity, which is close to one end of the safety helmet, a second blocking layer is arranged in a cavity of the liquid injection cavity, which is close to one end of the vas deferens body, the first blocking layer consists of a temperature sensing material, and the second blocking layer consists of a water-soluble material. When the sow needs to be pregnant, semen is firstly filled into the vas deferens body, and the semen is automatically ablated when meeting water because the second blocking layer is made of water-soluble materials; then the safety helmet at the front end of the injection pipe is broken by hand, and the safety helmet and the injection pipe are broken at the easy-to-break position; when the injection tube is placed in the sow birth canal, the first blocking layer is melted due to the fact that the first blocking layer is made of a temperature-sensitive material, and semen is pressed into the birth canal by the vas deferens body.
The first occlusion layer temperature sensing material adopts mixed fatty acid glyceride, which is composed of single, double and triglyceride of mixed fatty acid (C10-C18), and the triester is the main component, and the traditional fatty acid glyceride has a melting point lower than the temperature of the sow organism, which can lead to the premature injection of semen by the automatic vas deferens device and has high price. Some low temperature waxes have poor biocompatibility and may respond or undergo rejection to the host or user, and the biological material must be safe, at least so that the reaction can be accepted by the user without deleterious effects.
Disclosure of Invention
The utility model aims to provide a Wen Minla material for automatic seminiferous ducts for sow conception and a preparation method thereof, which are used for solving the problem that the low-temperature wax effect in the prior art cannot meet the requirement. The utility model introduces a new biocompatible system and a stabilizing system, can realize one-step mixed hot melting preparation in production, and the generated temperature-sensitive wax material for the automatic seminiferous duct for sow conception has uniform components and high stability, can obviously reduce the softening temperature of low-temperature wax and is highly matched with the body temperature of a user; the Wen Minla material for the automatic insemination tube of the sow is an oil-soluble material and is not a water-soluble material, so that bionic biological instruments such as the automatic insemination tube can not be dissolved by semen when being used as parts at normal temperature, and has a good barrier effect.
In order to achieve the above purpose, the utility model adopts the following technical scheme:
one of the purposes of the utility model is to provide Wen Minla material for automatic seminiferous duct of sow conception, wen Minla material for automatic seminiferous duct of sow conception is prepared from the following components in percentage by weight: 61-69% of beeswax, 8-12% of binder, 12-18% of lubricant and 100% of filler. The Wen Minla material for the sow conception automatic seminiferous duct is prepared by mixing beeswax, a binder, a lubricant and a filler, heating until all components reach a molten state, uniformly mixing, pouring into a mold, and cooling to room temperature. It should be noted that: the heating temperature is a temperature at which the mixture melts and oxidative decomposition does not occur.
The technical proposal takes beeswax as a substrate, the beeswax is a natural product, has strong plasticity and is safe and harmless; the beeswax, the lubricant and the filler can be effectively bonded with each other and uniformly dispersed by adding the binder; the flowability of the whole wax material can be effectively increased by adding the lubricant, and the softening temperature of the wax material can be effectively reduced; the filler can be added to effectively fill gaps among the beeswax, the binder and the lubricant, so that the influence of thermal expansion is effectively reduced. Further, the beewax in the technical scheme is bleached or unbleached beewax, and the melting point is 46-60 ℃.
Further, the binder in the above technical scheme is gelatin. In the technical scheme, the gelatin is used as the binder and has thermal reversibility, the gelatin-added product is in a solution state when being heated and in a congealed state after being cooled, the conversion is rapid and can be repeatedly carried out for many times, meanwhile, the basic characteristics of the product are not changed, the binding force is stronger, and the integrity of the product can be maintained.
Further, the lubricant in the technical scheme is a mixture of oleic acid glyceride and palmitic acid glyceride, preferably the mass ratio of oleic acid glyceride to palmitic acid glyceride is 3-5: 1. The oleic acid glyceride and the palmitic acid glyceride have lubricating effect, can be effectively melted in the beeswax, and reduce the whole melting range and softening temperature.
Further, according to the above technical scheme, the filler is cocoa butter. The melting point of the cocoa butter is close to the average human body temperature, so that the cocoa butter can be kept in a solid state at room temperature, is stable and easy to store, has good compatibility with beeswax, and the melting point of the whole wax material cannot be obviously influenced by the filling agent cocoa butter in the technical scheme.
The second purpose of the utility model is to provide a preparation method of Wen Minla material for automatic seminiferous duct for sow conception, which comprises the following steps:
s1, respectively crushing beewax, a binder and a filler into powder, sieving, and weighing according to a proportion for later use;
s2, adding the beeswax, the binder and the filler into a heat-collecting magnetic stirrer, and uniformly stirring and mixing the powder;
s3, adding the lubricant into a heat-collecting magnetic stirrer, and stirring while heating until beeswax, binder, filler and lubricant are fully melted and uniformly mixed;
s4, pouring the materials which are melted and mixed uniformly into a mould, cooling the materials, and taking out the materials to obtain the Wen Minla material for the automatic seminiferous duct for sow conception.
According to the technical scheme, beeswax, a binder and a filler are uniformly mixed, a lubricant is added, the mixture is heated and stirred at the same time, all components reach a molten state, stirring is continued to fully and uniformly mix the components, then the molten materials are poured into a mold and cooled to room temperature, and the prepared Wen Minla material for the sow conception automatic seminiferous duct is highly matched with the body temperature of a user, so that no harmful effect is generated.
Further, in the above technical scheme S1, the powder is sieved with a 100-150 mesh sieve.
Further, in the above technical scheme S2, the stirring speed is 30-50r/min, and the mixing time is preferably 8-12min.
Further, in the above technical solution S3, the heating and stirring conditions are: the stirring speed is 60-100r/min, the heating temperature is selected to be a temperature at which the mixture melts and no oxidative decomposition occurs, preferably the heating temperature is 90-120 ℃, and preferably the mixing time is 15-30min.
Further, in the above-mentioned technical aspect S4, the injection molding conditions are: the surface of the die is smooth, clean and sanitary.
The utility model also provides the application of the Wen Minla material for the automatic conception and delivery tube of the sow in preparing a solid preparation with a certain shape for administration in a biological cavity, and in particular application, the solid preparation with a certain shape for administration in a biological cavity is prepared by the drug and the Wen Minla material for the automatic conception and delivery tube of the sow.
The utility model aims at providing Wen Minla material for automatic seminiferous duct of sow conception, which is one of the aims of the utility model, and the application of the material for automatic seminiferous duct of sow conception in the preparation of parts for improving the fertilization of organisms by matching with bionic biological instruments such as automatic seminiferous duct, especially the automatic seminiferous duct of China utility model with the authorized publication number of CN 217744696U.
Compared with the prior art, the utility model has the beneficial effects that:
1. the softening temperature of the beeswax is higher than the body temperature of pigs, and the beeswax is not suitable for direct use of automatic vas deferens. According to the utility model, the oleic acid glyceride and the palmitic acid glyceride are added into the beeswax, so that the softening temperature of the beeswax is effectively reduced, and the beeswax is effectively mixed and melted with the oleic acid glyceride and the palmitic acid glyceride, so that the beeswax is well matched with an automatic insemination device. The Wen Minla material for the automatic insemination tube of the sow provided by the utility model is an oil-soluble material and is not a water-soluble material, so that at normal temperature, a bionic biological instrument such as the automatic insemination tube is used as a part and cannot be dissolved by semen, a good barrier effect is achieved, when the automatic insemination tube is placed in a sow body, the sow automatic insemination tube begins to soften when the temperature of the Wen Minla material for the automatic insemination tube reaches the body temperature of the sow, and the semen in the automatic insemination tube sprays a wax material to the sow body through a pipeline under a certain pressure;
2. the utility model has good biocompatibility, all components can not generate a certain response or rejection reaction to a host or a user, and the biocompatible wax ensures safety and can not generate harmful effects;
3. in the utility model, beeswax, binder, lubricant and filler are melt blended in a proper proportion to achieve a stable state, so that the beeswax can be stored stably for a long time. The Wen Minla material for the automatic insemination tube of the sow simplifies the production process, adopts the biocompatible material, effectively simplifies the production process and reduces the economic and time costs.
Drawings
Fig. 1 shows apparent states of Wen Minla material for automatic conception and seminiferous duct of sow prepared in example 1 of the present utility model at different temperatures. The left Wen Minla material was in a fluid liquid state at 38 ℃, and the right Wen Minla material was in a solidified state at 25 ℃.
Fig. 2 is a graph of the rheological results of the sow conception automatic seminiferous duct Wen Minla material prepared in example 1 of the present utility model, specifically, a graph of the change of storage modulus (G') and loss modulus (G ") with temperature, showing the change of viscoelasticity of Wen Minla material in the range of 25-55 ℃. It can be seen that Wen Minla material is in viscous state at 35-45 deg.C, and meets the body temperature characteristics of living body.
FIG. 3 is a DSC curve of the material Wen Minla for automatic seminiferous ducts for sow conception prepared in example 1 of the present utility model. It can be seen that a significant melting peak appears, and the melting range of the Wen Minla material for automatic conception and vas deferens for sow prepared in example 1 is 36-42 ℃, the melting point is 40 ℃, and the material meets the body temperature characteristics of organisms.
Fig. 4 is a schematic diagram of the situation that the material Wen Minla for automatic seminiferous ducts for sow conception prepared in example 1 of the present utility model is dissolved in ethyl acetate for 2min, and with the assistance of an infrared thermal imager as a reference, it is obvious that the material Wen Minla for automatic seminiferous ducts for sow conception prepared in example 1 can be dissolved in ethyl acetate at 35 ℃ and 40 ℃.
Fig. 5 is a schematic diagram of the situation that the material Wen Minla for sow conception automatic vas deferens prepared in the embodiment 1 of the utility model is dissolved in water for 2min, and by taking an infrared thermal imager as a reference, it is obvious that the material Wen Minla for sow conception automatic vas deferens prepared in the embodiment 1 is difficult to be dissolved in water at 35 ℃ and 40 ℃.
Detailed Description
The utility model will be further described with reference to the following detailed description, which, unless otherwise indicated, is a conventional process. It is to be understood that these examples are provided only for illustrating the present utility model and are not intended to limit the scope of the claimed utility model. It is also to be understood that various modifications may be made to the utility model by those skilled in the art after reading the disclosure herein, and such equivalents are intended to fall within the scope of the utility model.
The raw materials used in the following examples and comparative examples are all disclosed in the prior art, if not particularly limited, and may be obtained, for example, directly or prepared according to the preparation method disclosed in the prior art.
The raw materials used in the following examples and comparative examples, beeswax (CAS: 8012-89-3, bleached, melting point: 46-60 ℃), gelatin (CAS: 9000-70-8), xanthan gum, glyceryl oleate, glyceryl palmitate, cocoa butter (CAS: 8002-31-1), etc., were all purchased from Adamas.
Example 1
Wen Minla material for automatic seminiferous duct of sow conception is prepared from the following components in percentage by weight: 61% of beeswax, 8% of a binder, 12% of a lubricant and 19% of a filler, wherein the binder is gelatin, the lubricant is a mixture of oleic acid glyceride and palmitic acid glyceride, and the mass ratio of oleic acid glyceride to palmitic acid glyceride is 3:1, a step of; the filler is cocoa butter.
The method comprises the following specific steps:
s1, taking 50g of Wen Minla material for automatic seminiferous duct for sow conception as an example, respectively crushing beewax, a binder and a filler into powder, sieving with a 100-mesh sieve, and weighing according to a proportion for later use;
s2, adding the beeswax, the binder and the filler into a heat-collecting magnetic stirrer, and stirring for 8min at a stirring speed of 30r/min to uniformly stir and mix the powder;
s3, adding the lubricant into a heat-collecting magnetic stirrer, heating and stirring at the stirring speed of 60r/min, heating to 90 ℃ and continuously stirring for 15min to ensure that the beeswax, the binder, the filler and the lubricant are fully melted and uniformly mixed;
s4, pouring the material obtained by the even melting and mixing of the step S3 into a mold with smooth and clean surface, cooling the material, and taking out the material to obtain the Wen Minla material for the automatic seminiferous duct for sow conception.
Example 2
Wen Minla material for automatic seminiferous duct of sow conception is prepared from the following components in percentage by weight: 63% of beeswax, 10% of a binder, 14% of a lubricant and 13% of a filler, wherein the binder is gelatin, the lubricant is a mixture of oleic acid glyceride and palmitic acid glyceride, and the mass ratio of oleic acid glyceride to palmitic acid glyceride is 4:1, a step of; the filler is cocoa butter.
The method comprises the following specific steps:
s1, taking 50g of Wen Minla material for automatic seminiferous duct for sow conception as an example, respectively crushing beewax, a binder and a filler into powder, sieving with a 100-mesh sieve, and weighing according to a proportion for later use;
s2, adding the beeswax, the binder and the filler into a heat-collecting magnetic stirrer, and stirring for 10min at a stirring speed of 40r/min to uniformly stir and mix the powder;
s3, adding the lubricant into a heat-collecting magnetic stirrer, heating and stirring at the stirring speed of 70r/min, and heating to 100 ℃ and continuously stirring for 15min to ensure that the beeswax, the binder, the filler and the lubricant are fully melted and uniformly mixed;
s4, pouring the material obtained by the even melting and mixing of the step S3 into a mold with smooth and clean surface, cooling the material, and taking out the material to obtain the Wen Minla material for the automatic seminiferous duct for sow conception.
Example 3
Wen Minla material for automatic seminiferous duct of sow conception is prepared from the following components in percentage by weight: 66% of beeswax, 10% of a binder, 16% of a lubricant and 8% of a filler, wherein the binder is gelatin, the lubricant is a mixture of oleic acid glyceride and palmitic acid glyceride, and the mass ratio of oleic acid glyceride to palmitic acid glyceride is 4:1, a step of; the filler is cocoa butter.
The method comprises the following specific steps:
s1, taking 50g of Wen Minla material for automatic seminiferous duct for sow conception as an example, respectively crushing beewax, a binder and a filler into powder, sieving with a 150-mesh sieve, and weighing according to a proportion for later use;
s2, adding the beeswax, the binder and the filler into a heat-collecting magnetic stirrer, and stirring for 12min at a stirring speed of 40r/min to uniformly stir and mix the powder;
s3, adding the lubricant into a heat-collecting magnetic stirrer, heating and stirring at the stirring speed of 90r/min, and heating to 110 ℃ and continuously stirring for 25min to ensure that the beeswax, the binder, the filler and the lubricant are fully melted and uniformly mixed;
s4, pouring the material obtained by the even melting and mixing of the step S3 into a mold with smooth and clean surface, cooling the material, and taking out the material to obtain the Wen Minla material for the automatic seminiferous duct for sow conception.
Example 4
Wen Minla material for automatic seminiferous duct of sow conception is prepared from the following components in percentage by weight: 69% of beeswax, 10% of a binder, 18% of a lubricant and 3% of a filler, wherein the binder is gelatin, the lubricant is a mixture of oleic acid glyceride and palmitic acid glyceride, and the mass ratio of oleic acid glyceride to palmitic acid glyceride is 5:1, the filler is cocoa butter.
The method comprises the following specific steps:
s1, taking 50g of Wen Minla material for automatic seminiferous duct for sow conception as an example, respectively crushing beewax, a binder and a filler into powder, sieving with a 150-mesh sieve, and weighing according to a proportion for later use;
s2, adding the beeswax, the binder and the filler into a heat-collecting magnetic stirrer, and stirring for 12min at a stirring speed of 50r/min to uniformly stir and mix the powder;
s3, adding the lubricant into a heat-collecting magnetic stirrer, heating and stirring at the stirring speed of 100r/min, heating to 120 ℃ and continuously stirring for 30min to ensure that the beeswax, the binder, the filler and the lubricant are fully melted and uniformly mixed;
s4, pouring the material obtained by the even melting and mixing of the step S3 into a mold with smooth and clean surface, cooling the material, and taking out the material to obtain the Wen Minla material for the automatic seminiferous duct for sow conception.
Comparative example 1
Wen Minla material for automatic seminiferous duct of sow conception has the same components, percentage of components and preparation method as in example 4, except that the binder is xanthan gum.
Comparative example 2
Wen Minla material for automatic seminiferous duct of sow conception is prepared from the following components in percentage by weight: 72% of beeswax, 10% of binder, 14% of lubricant and 4% of filler, and the components and the preparation method are exactly the same as in example 4.
Comparative example 3
Wen Minla material for automatic seminiferous duct of sow conception has the same components, percentage of components and preparation method as in example 4, except that the lubricant used is oleic glyceride.
Comparative example 4
Wen Minla material for automatic seminiferous duct of sow conception is prepared from the following components in percentage by weight: 55% of beeswax, 12% of binder, 18% of lubricant and 15% of filler, and the components and the preparation method are exactly the same as in example 4.
The materials Wen Minla for sow conception automatic seminiferous ducts prepared in examples 1 to 4 and comparative examples 1 to 4 were subjected to the test and recording of softening temperature, and the prepared material Wen Minla for sow conception automatic seminiferous duct (hereinafter simply referred to as "wax material", not described in detail) was placed in the automatic seminiferous duct in chinese patent example 1 of patent publication No. CN 217744696U as a first blocking layer, the timing was started from the placement of the automatic seminiferous duct into the sow, the timing was stopped when the wax material started to soften and semen was ejected from the sow, and the softening temperature (melting range) was tested and the time required for melting was recorded. Specifically, the wax material prepared in each case is injected into an automatic vas deferens, the wax material content in each vas deferens is 5mg, 1000 samples are taken in each case to carry out in-vivo fertilization simulation test of a sow, and the softening temperature range and the softening time range of each sample are recorded.
TABLE 1 softening temperature Range results (personal)
| Group of | At a temperature below 34 DEG C | 34-36℃ | 36-38℃ | 38-40℃ | 40-42℃ | At a temperature of above 42 DEG C |
| Example 1 | 0 | 58 | 562 | 369 | 11 | 0 |
| Example 2 | 0 | 44 | 503 | 394 | 59 | 0 |
| Example 3 | 0 | 22 | 475 | 457 | 46 | 0 |
| Example 4 | 0 | 8 | 412 | 488 | 92 | 0 |
| Comparative example 1 | 0 | 0 | 7 | 19 | 589 | 385 |
| Comparative example 2 | 0 | 0 | 12 | 27 | 654 | 307 |
| Comparative example 3 | 0 | 65 | 239 | 241 | 295 | 160 |
| Comparative example 4 | 426 | 454 | 75 | 45 | 0 | 0 |
Note that: the softening temperature is set to 34-36 ℃, 36-38 ℃, 38-40 ℃ and 40-42 ℃ respectively, and the temperature ranges excluding the left end point value and the right end point value are included, and the softening temperature is set to be within the range of 36-38 ℃ by taking 38 ℃ as an example. The softening temperature is below 34 ℃ and above 42 ℃, and the temperature deviating from the sow birth canal is too high, so that the sow feed has no reference value.
As can be seen from the results of table 1, the softening temperature of Wen Minla material for automatic conception vas deferens of sows, which is obtained by adopting the formulation and the preparation method (examples 1-4) of the utility model, is concentrated at 36-40 ℃ to meet the temperature of the birth canal of sows, wax materials can be melted in the temperature range, and xanthan gum is used as the binder in comparative example 1, and the melting point is higher than that of gelatin, so that the softening temperature is concentrated at more than 40 ℃; the beeswax content in comparative example 2 was high, and the softening temperature was mostly concentrated above 40 ℃; the lubricant in the comparative example 3 only contains oleic glyceride, so that the components of the materials are unevenly mixed, the softening temperature of the obtained product is higher, the softening temperature distribution is not concentrated, and the product percent of pass is low; the beeswax content in comparative example 4 was low, the softening temperature of the resulting product was low, and the softening temperature was mostly concentrated below 40 ℃.
TABLE 2 softening time Range results (personal)
| Group of | 0-1min | 1-2min | 2-3min | 3-4min | 4-5min | For more than 5min |
| Example 1 | 0 | 525 | 453 | 22 | 0 | 0 |
| Example 2 | 0 | 503 | 452 | 45 | 0 | 0 |
| Example 3 | 0 | 485 | 459 | 56 | 0 | 0 |
| Example 4 | 0 | 469 | 463 | 68 | 0 | 0 |
| Comparative example 1 | 0 | 31 | 85 | 365 | 256 | 263 |
| Comparative example 2 | 0 | 45 | 96 | 331 | 243 | 285 |
| Comparative example 3 | 69 | 56 | 286 | 248 | 256 | 85 |
| Comparative example 4 | 846 | 106 | 48 | 0 | 0 | 0 |
Note that: the time ranges of the softening time are set to be 0-1min, 1-2min, 2-3min, 3-4min and 4-5min, wherein the time ranges do not include the left endpoint value and include the right endpoint value, and the time ranges are counted in the interval of 1-2min by taking 2min as an example. The softening time is less than 1min, the temperature is more than 5min, and the normal artificial insemination time of the sow is deviated, so that the sow has no reference value.
As can be seen from the results in Table 2, the softening time of Wen Minla material for automatic conception vas deferens of sows obtained by adopting the formula and the preparation method (examples 1-4) is concentrated for 1-3min, and the time requirement of artificial insemination is met. In the comparative example 1, xanthan gum is used as the binder, the melting point is higher than that of gelatin, and the softening temperature of the final wax material is higher, so that the softening time is mostly concentrated over 3 minutes; in comparative example 2, the beeswax content is higher, the softening temperature of the final wax material is higher, and the softening time is mostly concentrated above 3 min; the lubricant in the comparative example 3 only contains oleic glyceride, so that the components of the materials are unevenly mixed, the softening temperature of the obtained product is higher, the softening time distribution is not concentrated, and the product percent of pass is low; the beeswax content in comparative example 4 was low, the softening temperature of the obtained product was low, and the softening time was mostly concentrated within 1 min.
In conclusion, the Wen Minla material for the automatic conception vas deferens for the sow has good biocompatibility and high stability by reasonable proportion and a simple and scientific mixing method, and is compatible with the characteristics of biological signs and convenient to use.
It should be emphasized that the above description is only of a preferred embodiment of the utility model, and is not intended to limit the utility model, but it should be noted that modifications and adaptations to those skilled in the art can be made without departing from the principle of the utility model, and the modifications and adaptations should and are intended to be comprehended within the scope of the utility model.
Claims (10)
1. Wen Minla material for automatic seminiferous duct of sow conception is characterized by comprising the following components in percentage by weight: 61-69% of beeswax, 8-12% of binder, 12-18% of lubricant and 100% of filler;
the binder is gelatin; the lubricant is a mixture of oleic acid glyceride and palmitic acid glyceride; the filler is cocoa butter.
2. A sow conception automatic vas deferens Wen Minla material according to claim 1, wherein the lubricant is oleic acid glyceride and palmitic acid glyceride in a mass ratio of 3-5: 1.
3. A sow conception automatic vas deferens Wen Minla material according to claim 1, wherein said beeswax has a melting point of 46-60 ℃.
4. A method for preparing Wen Minla material for automatic seminiferous ducts for sow conception according to any one of claims 1-3, comprising the following specific steps:
s1, respectively crushing beewax, a binder and a filler into powder, sieving, and weighing according to a proportion for later use;
s2, adding the beeswax, the binder and the filler into a heat-collecting magnetic stirrer, and uniformly stirring and mixing the powder;
s3, adding the lubricant into a heat-collecting magnetic stirrer, and stirring while heating until beeswax, binder, filler and lubricant are fully melted and uniformly mixed;
s4, pouring the materials which are melted and mixed uniformly into a mould, cooling the materials, and taking out the materials to obtain the Wen Minla material for the automatic seminiferous duct for sow conception.
5. The method for preparing Wen Minla material for automatic seminiferous duct for sow conception according to claim 4, wherein in step S1, the powder of beeswax, binder and filler is sieved with a 100-150 mesh sieve.
6. The method for preparing Wen Minla material for automatic seminiferous duct for sow conception according to claim 4, wherein in step S2, the stirring speed is 30-50r/min, and the mixing time is 8-12min.
7. The method for preparing Wen Minla material for automatic seminiferous duct for sow conception according to claim 4, wherein in step S3, the stirring speed is 60-100r/min, the heating temperature is 90-120 ℃, and the mixing time is 15-30min.
8. The method for preparing Wen Minla material for automatic seminiferous duct for sow conception according to claim 4, wherein the mold used in step S4 is smooth, clean and sanitary.
9. Use of a Wen Minla material for automatic seminiferous duct in sow conception according to any one of claims 1 to 3 in the manufacture of a solid preparation shaped for intra-biological administration or in the manufacture of parts for use in connection with bionic biological instruments for improving the fertilization of a living organism.
10. Use of a Wen Minla material for automatic seminiferous ducts of sows according to any one of claims 1 to 3 for improving the fertilization of organisms in combination with parts made of automatic seminiferous ducts.
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| CN217744696U (en) * | 2022-04-02 | 2022-11-08 | 武汉天楚生物科技有限公司 | Automatic vas deferens |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20100263675A1 (en) * | 2009-04-21 | 2010-10-21 | Ansell Healthcare Products Llc | Condom with Localized Active Agent |
| FR2953724B1 (en) * | 2009-12-14 | 2012-01-13 | Genes Diffusion | SWINE SEMINAL MATERIAL COMPOSITION FOR ARTIFICIAL INSEMINATION OF SOWS |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2973696A1 (en) * | 2011-04-06 | 2012-10-12 | Lichtenberg Jacques Frank | Cosmetic and/or dermatological composition, useful to nourish/hydrate skin for its protection and/or to prevent and reduce wrinkles, comprises waxes including e.g. beeswax and/or white wax and compounds including e.g. mineral oils |
| CN105854022A (en) * | 2011-05-30 | 2016-08-17 | 钟术光 | Drug carrier capable of slowly releasing drug |
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| CN217744696U (en) * | 2022-04-02 | 2022-11-08 | 武汉天楚生物科技有限公司 | Automatic vas deferens |
| CN115887352A (en) * | 2022-10-12 | 2023-04-04 | 安康市食品药品检验检测中心(药械不良反应监测中心) | Rifapentine double-layer suppository, preparation method and application |
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