GB487506A - Manufacture of medicinal depots, masses for infusion, stiffening agents, plastic fillings and the like - Google Patents

Manufacture of medicinal depots, masses for infusion, stiffening agents, plastic fillings and the like

Info

Publication number
GB487506A
GB487506A GB505/37A GB50537A GB487506A GB 487506 A GB487506 A GB 487506A GB 505/37 A GB505/37 A GB 505/37A GB 50537 A GB50537 A GB 50537A GB 487506 A GB487506 A GB 487506A
Authority
GB
United Kingdom
Prior art keywords
polyvinyl alcohol
yield
masses
mass
heated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB505/37A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHEMISCHE FORSCHUNGS GmbH
Original Assignee
CHEMISCHE FORSCHUNGS GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHEMISCHE FORSCHUNGS GmbH filed Critical CHEMISCHE FORSCHUNGS GmbH
Publication of GB487506A publication Critical patent/GB487506A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B04—CENTRIFUGAL APPARATUS OR MACHINES FOR CARRYING-OUT PHYSICAL OR CHEMICAL PROCESSES
    • B04B—CENTRIFUGES
    • B04B1/00—Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles
    • B04B1/04—Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles with inserted separating walls
    • B04B1/06—Centrifuges with rotary bowls provided with solid jackets for separating predominantly liquid mixtures with or without solid particles with inserted separating walls of cylindrical shape

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Inorganic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

Sterile masses suitable for use as medicinal depot carriers, depot base substances, masses for infusion and plastic fillings, are prepared by heating a paste or solution of polyvinyl alcohol or a derivative thereof capable of dissolving or swelling in water containing an iron or chromium compound, a dyestuff of the Congo Red group or sodium acetate, to a temperature above 100 DEG C. in a closed vessel. Therapeutic agents (such as alkaloids, cardiacs and gland preparations) or electrolytes accelerating the resorption of the mass may be added. Resorption of the mass may be retarded by treatment with rays. The consistency may be modified by addition of oils, hydrocarbons, or glycerine. In examples: (1) aqueous polyvinyl alcohol is mixed with Congo Red and after sterilization blended with sterile dilute hydrochloric acid and thyreotropic hormone to yield a mass which solidifies in the body after injection; (2) aqueous polyvinyl alcohol is heated with ammonium bichromite to yield a paste which may be used as a joint lubricant; (3) aqueous polyvinyl alcohol is heated with benzopurpurin to yield a product that may be used for stiffening tissues, for supporting the mediastinum, or for filling cavities; (4) aqueous polyvinyl alcohol is heated with Congo Red and lactic acid to yield a mass that may be injected into the body. Specifications 476,314 and 476,426 are referred to. The Specification as open to inspection under Sect. 91 refers in general to the use of polyvinyl alcohol or a derivative thereof capable of swelling in water as medicinal depot carriers, masses for infusion or plastic fillings. This generalization does not appear in the Specification as accepted.ALSO:Sterile masses, suitable for use as medicinal dep<\>zot carriers, dep<\>zot base substances, masses for infusion and plastic fillings, are prepared by heating a paste or solution of polyvinyl alcohol, or a derivative thereof capable of dissolving or swelling in water, containing an iron or chromium compound, a dyestuff of the Congo Red group, or sodium acetate to a temperature above 100 DEG C. in a closed vessel. Theurapeutic agents (such as alkaloids, cardiacs and gland substances) or electrolytes varying the rate of resorption may be added. Resorption of the mass may be retarded by treatment with various rays. In examples: (1) aqueous polyvinyl alcohol is mixed with Congo red, sterilized, and blended with thyreotropic hormone to yield a mass solidifying in the body after injection; (2) aqueous polyvinyl alcohol is heated with ammonium bichromate to yield a pasty joint lubricant; (3) aqueous polyvinyl alcohol is heated with benzopurpurin to yield a product suitable for sticking tissues, supporting the mediastinum and for filling cavities; (4) aqueous polyvinyl alcohol is heated with Congo Red and lactic acid to yield a mass suitable for injection. Specifications 476,314 and 476,426, [both in Group IV], are referred to. The Specification as open to inspection under Sect. 91 refers to the use, in general, of polyvinyl alcohol or a water-swellable derivative thereof as medicinal dep<\>zot carriers, masses for infusion or plastic fillings. This generalization does not appear in the Specification as accepted.
GB505/37A 1936-01-08 1937-01-07 Manufacture of medicinal depots, masses for infusion, stiffening agents, plastic fillings and the like Expired GB487506A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE203548X 1936-01-08
DE220636X 1936-06-22

Publications (1)

Publication Number Publication Date
GB487506A true GB487506A (en) 1938-06-22

Family

ID=25759449

Family Applications (1)

Application Number Title Priority Date Filing Date
GB505/37A Expired GB487506A (en) 1936-01-08 1937-01-07 Manufacture of medicinal depots, masses for infusion, stiffening agents, plastic fillings and the like

Country Status (4)

Country Link
BE (1) BE419345A (en)
CH (2) CH203548A (en)
FR (1) FR827297A (en)
GB (1) GB487506A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2930695A (en) * 1956-02-23 1960-03-29 Rosner Hixson Lab Inc Animal feed supplement

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2930695A (en) * 1956-02-23 1960-03-29 Rosner Hixson Lab Inc Animal feed supplement

Also Published As

Publication number Publication date
FR827297A (en) 1938-04-22
CH227394A (en) 1943-06-15
BE419345A (en)
CH203548A (en) 1939-03-15

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