CN116492285B - 一种用于口腔的复合益生菌组合物及其应用和产品 - Google Patents
一种用于口腔的复合益生菌组合物及其应用和产品 Download PDFInfo
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- CN116492285B CN116492285B CN202310778286.5A CN202310778286A CN116492285B CN 116492285 B CN116492285 B CN 116492285B CN 202310778286 A CN202310778286 A CN 202310778286A CN 116492285 B CN116492285 B CN 116492285B
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Abstract
Description
牙龈指数 | 牙周袋深度/mm | |
正常对照组 | 0.4±0.5 | 0.503±0.091 |
模型组 | 2.8±0.4## | 1.458±0.075## |
S1组 | 1.8±0.7* | 0.950±0.103* |
S2组 | 1.6±0.5* | 0.921±.0.121* |
S3组 | 1.4±0.5* | 0.894±.0.041* |
D1组 | 2.2±0.4* | 1.337±0.108 |
D2组 | 2.4±0.5 | 1.356±0.047 |
D3组 | 2.6±0.5 | 1.396±0.132 |
D4组 | 2.0±0.6* | 1.327±0.118 |
Claims (6)
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108553406A (zh) * | 2018-07-24 | 2018-09-21 | 北京斯利安药业有限公司 | 一种组合物、其应用及具有改善口腔健康作用的口服制剂 |
CN109717289A (zh) * | 2019-01-31 | 2019-05-07 | 安徽仙奇生物工程技术有限公司 | 一种爆珠口香糖及其制备方法 |
CN110051003A (zh) * | 2019-04-24 | 2019-07-26 | 广州能靓生物技术有限公司 | 一种复合益生菌组合物及其应用 |
CN111820407A (zh) * | 2020-08-31 | 2020-10-27 | 北京同禧科技有限公司 | 一种抗幽门螺旋杆菌组合物及其应用 |
JP2021172620A (ja) * | 2020-04-27 | 2021-11-01 | A Lavender.Com株式会社 | 口腔ケア剤 |
CN114027505A (zh) * | 2021-11-09 | 2022-02-11 | 仙乐健康科技股份有限公司 | 一种用于口腔内含服的泡腾片 |
CN114748608A (zh) * | 2020-12-25 | 2022-07-15 | 上海利康消毒高科技有限公司 | 抗口腔幽门螺杆菌爆珠口香丸及制备方法 |
CN115812824A (zh) * | 2022-12-13 | 2023-03-21 | 南昌大学 | 一种益生菌爆珠软糖及其制备 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040265247A1 (en) * | 2003-05-20 | 2004-12-30 | Gc Corporation | Mouth rinse composition |
US20190076497A1 (en) * | 2017-09-11 | 2019-03-14 | Kenneth Davin Fine | Oral and intestinal health products |
-
2023
- 2023-06-29 CN CN202310778286.5A patent/CN116492285B/zh active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108553406A (zh) * | 2018-07-24 | 2018-09-21 | 北京斯利安药业有限公司 | 一种组合物、其应用及具有改善口腔健康作用的口服制剂 |
CN109717289A (zh) * | 2019-01-31 | 2019-05-07 | 安徽仙奇生物工程技术有限公司 | 一种爆珠口香糖及其制备方法 |
CN110051003A (zh) * | 2019-04-24 | 2019-07-26 | 广州能靓生物技术有限公司 | 一种复合益生菌组合物及其应用 |
JP2021172620A (ja) * | 2020-04-27 | 2021-11-01 | A Lavender.Com株式会社 | 口腔ケア剤 |
CN111820407A (zh) * | 2020-08-31 | 2020-10-27 | 北京同禧科技有限公司 | 一种抗幽门螺旋杆菌组合物及其应用 |
CN114748608A (zh) * | 2020-12-25 | 2022-07-15 | 上海利康消毒高科技有限公司 | 抗口腔幽门螺杆菌爆珠口香丸及制备方法 |
CN114027505A (zh) * | 2021-11-09 | 2022-02-11 | 仙乐健康科技股份有限公司 | 一种用于口腔内含服的泡腾片 |
CN115812824A (zh) * | 2022-12-13 | 2023-03-21 | 南昌大学 | 一种益生菌爆珠软糖及其制备 |
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