CN116491507A - Composition containing pyrazole amide compound and application of composition in preventing or controlling powdery mildew - Google Patents

Composition containing pyrazole amide compound and application of composition in preventing or controlling powdery mildew Download PDF

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Publication number
CN116491507A
CN116491507A CN202210077957.0A CN202210077957A CN116491507A CN 116491507 A CN116491507 A CN 116491507A CN 202210077957 A CN202210077957 A CN 202210077957A CN 116491507 A CN116491507 A CN 116491507A
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pyrazole amide
composition
powdery mildew
plant
composition containing
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罗昌炎
詹姆斯·T·布里斯托
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Jiangsu Rotam Chemical Co Ltd
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Jiangsu Rotam Chemical Co Ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
    • A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to a composition containing pyrazole amide compounds and application thereof in preventing or controlling powdery mildew, belongs to the technical field of pesticides, and relates to a composition containing pyrazole amide compounds, and also relates to application of the composition in preventing or controlling fungal diseases, especially application in preventing or controlling powdery mildew, and more especially application in preventing or controlling melon powdery mildew. The invention also relates to a method for preventing or controlling the attack of plants, plant parts, plant propagation material and subsequently growing plant organs from phytopathogenic fungi. The composition containing the pyrazole amide compound comprises fluxapyroxad hydroxylamine and metrafenone, wherein the weight ratio of the fluxapyroxad hydroxylamine to the metrafenone is 20:1-1:20.

Description

Composition containing pyrazole amide compound and application of composition in preventing or controlling powdery mildew
Technical Field
The invention relates to a composition containing pyrazole amide compounds and application thereof in preventing or controlling powdery mildew, belongs to the technical field of pesticides, and relates to a composition containing pyrazole amide compounds, in particular to a composition containing fluxapyroxad hydroxylamine and metrafenone; the invention also relates to the application of the composition in preventing or controlling fungal diseases, especially in preventing or controlling powdery mildew, and more especially in preventing or controlling melon powdery mildew.
Background
Powdery mildew is one of important diseases of melon crops, is a frequently-occurring disease, is commonly generated on various melons cultivated in open field and facilities, and is relatively common on melon, cucumber, pumpkin and other crops. Once this occurs, it can spread in a short period of time, bringing significant losses to farmer production.
Fluxapyroxad hydroxylamine (pydifumetofen) is a pyrazole amide fungicide developed first, and is one of the most valuable products in succinic dehydrogenase inhibitor (SDHI) bactericides. Not only has good systemic activity, excellent protection, treatment and eradication activities, but also has long lasting period. A large number of field efficacy tests show that the fluxapyroxad hydroxylamine has good safety, good disease prevention and treatment effects and obvious yield increase, and compared with triazole bactericides, the fluxapyroxad hydroxylamine has wider bactericidal activity. But a single mechanism of action makes it at higher risk of resistance.
The Metrafenone (Metrafenone) belongs to a benzophenone bactericide, and is mainly used for inhibiting the spore germination of powdery mildew and controlling the spread of diseases by interfering the development and formation of attachment cells during the spore germination of pathogenic bacteria; meanwhile, the formation of mycelium top cells of germs is disturbed and inhibited by disturbing the establishment and formation of polar actin tissues, so that the normal development and growth of mycelium are hindered, the invasion of powdery mildew is inhibited and hindered, the harm of powdery mildew is effectively controlled, and certain protection and treatment effects are realized.
The single active ingredient fungicide varieties tend to be prone to the following problems in disease control: the sterilization spectrum is narrow; the drug resistance is easy to generate when the drug is continuously used, and the environment is polluted along with the increase of the application times; the two active components can produce synergistic effect by mixing, and the drug effect is obviously improved. Meanwhile, the reduction of the dosage of the active ingredients delays the generation of drug resistance and reduces environmental pollution.
Disclosure of Invention
The invention aims to provide a composition containing pyrazole amide compounds and application thereof in preventing or controlling powdery mildew, wherein the composition containing pyrazole amide compounds comprises fluxapyroxad hydroxylamine and metrafenone. The composition has good synergistic effect, widens bactericidal spectrum, delays occurrence of resistance, improves bactericidal effect, prolongs life cycle of active ingredients, reduces dosage of medicament and protects environment.
After mixing different varieties of pesticides, three types of action are generally exhibited: additive action, synergistic action, and antagonistic action. However, three types of action cannot be predicted, and the three types of actions are different under the action of various factors such as the chemical nature of the active ingredient, the type of preparation, the composition of the preparation and the like. The composition of the invention has a synergistic effect on crop diseases and is safe to crops on the premise of reducing the application rate of the active ingredients and improving the sterilization spectrum of the known compounds.
The synergistic effect is particularly pronounced when the active compounds are present in the compositions according to the invention containing pyrazole amide compounds in particular weight ratios.
The composition containing pyrazole amide compounds and the application of preventing or controlling powdery mildew are realized by adopting the following technical scheme:
the composition containing pyrazole amide compounds comprises 20:1-1:20, preferably 20:1-1:10, preferably 20:1-1:5, preferably 15:1-1:5, more preferably 10:1-1:5, more preferably 5:1-1:5, more preferably 4:1-1:4, more preferably 4:1-1:2, more preferably 4:1-1:1 by weight of the fluoxastrobin and the metrafenone.
The fluxapyroxad hydroxylamine and the metrafenone in the compositions of the present invention comprise, for example, in the form of a single premix (ready-mix), in the form of a combined spray mixture consisting of separate formulations of the individual active ingredients, for example a tank-mix, and are administered sequentially over a suitably short period of time, for example hours or days.
The compositions of the invention containing pyrazole amide compounds contain one or more inert fillers or surfactants in addition to the active ingredient. The proportion of active ingredient may be from 0.05 to 75% by weight of the composition.
The composition containing the pyrazole amide compound can be prepared into various forms such as powder, emulsion, granule, microparticle, wettable powder, tablet, aerosol, liquid, suspension, paste, microcapsule, dry suspension, water dispersible granule, suspending agent and the like. Among them, the forms of granules, wettable powders, water-dispersible granules, suspensions, microparticles, aerosols, microcapsules, emulsions, liquids, powders, tablets and the like are more preferable. More preferably, the composition is in the form of granule, wettable powder, water dispersible granule, suspension, aqueous emulsion, microparticle, aerosol, or microcapsule. Most preferred are forms of granules, wettable powders, water dispersible granules, suspending agents, aqueous emulsions, and the like.
Suitable inert fillers can be divided into liquid carriers and solid carriers. Examples of the liquid carrier include water, isopropyl alcohol, butanol, tetrahydrofuran, ethylene glycol, propylene glycol, ethyl acetate, methyl oleate, dimethylformamide, dimethylacetamide, dimethylsulfoxide, vegetable oil, and the like. Examples of the solid carrier include animal and plant powders such as starch, activated carbon, soybean powder, wheat flour, wood flour, fish meal, and milk powder; mineral powders such as talc, kaolin, bentonite, calcium carbonate, zeolite, diatomaceous earth, white carbon, clay, alumina, and sulfur powder;
suitable surfactants may be dispersants, emulsifiers, wetting agents, penetrants, tackifiers, spreaders, stabilizers, and the like. Examples are polyoxyethylene alkylaryl ethers, phosphate esters of polyoxyethylene alcohols or phenols, fatty alcohol polyoxyethylene ethers, fatty acid esters of polyhydric alcohols, polyoxyethylene higher fatty acid esters, lignin sulfonates, branched copolymers of high molecular weight combs, naphthalene sulfonic acid polymers, alkylsulfonylsuccinates, butylnaphthalene sulfonates, alkylaryl sulfonates, condensates of fatty alcohols with ethylene oxide, fats and oils, protein hydrolysates, polyacrylates of alkyl naphthalene sulfonates, suitable oligosaccharides or polymers, for example based on acrylic acid, vinyl monomers, polyoxypropylene and/or polyoxyethylene alone or in combination with, for example, (poly) alcohols or (poly) amines.
In addition, if necessary, the composition may be mixed with other agricultural chemicals, for example, insecticides, acaricides, nematicides, bactericides, antiviral agents, attractants, herbicides, plant growth regulators, and the like, and in this case, more excellent effects may be exhibited in some cases.
The use of the composition containing pyrazole amide compounds for preventing or controlling fungal diseases.
The use of said compositions containing pyrazole amides for the prevention or control of fungal diseases caused by powdery mildew (Erysiphe), puccinia (Puccinia), botrytis (Botrytis), pyricularia (Pyricularia), helminthosporium (Helminthosporium), fusarium (Fusarium), septoria (Septoria), cercospora (Cercospora) and Alternaria) and Rhizoctonia (Rhizoctonia), camelina (Hemileia).
The use of the composition containing pyrazole amide compounds for preventing or controlling fungal diseases caused by powdery mildew (Erysiphe spp.).
The composition containing the pyrazole amide compound is used for preventing or controlling powdery mildew caused by wheat powdery mildew (Erysiphe graminis), grape powdery mildew (Uncinula necator), cucumber powdery mildew (Sphaerotheca fuligena) and apple powdery mildew (Podosphaera leucotricha).
The compositions containing pyrazole amide compounds are useful for protecting seeds, plant roots and shoots from attack by soil-borne fungi.
A method of preventing or controlling the infestation of plants, plant parts, plant propagation material, and subsequently growing plant organs by phytopathogenic fungi, comprising applying said composition comprising a pyrazole amide-based compound to the plants, plant parts, plant propagation material or the soil or cultivation medium in which the plants are growing or in which growth is desired, in an agronomically effective and substantially non-phytotoxic application amount by seed treatment, foliar application, stem application, soaking, instillation, casting, spraying, powdering, spreading or fuming.
A method of preventing or controlling the attack by phytopathogenic fungi on plants, plant parts, plant propagation material and subsequently growing plant organs, comprising applying the composition comprising a pyrazole amide compound according to claim 1 to the plants, plant parts, plant propagation material or the soil or cultivation medium in which the plants are growing or in which growth is desired, before or after the plants are infested by the phytopathogenic fungi.
The pyrazole amide-based compound-containing composition of the present invention has excellent activity against a wide range of plant pathogenic fungi such as ascomycetes, basidiomycetes, oomycetes and deuteromycetes.
Ascomycetes, including powdery mildew such as Erysiphe (Venturia inaequalis), including wheat powdery mildew (Erysiphe graminis), grape powdery mildew (Uncinula necator), cucumber powdery mildew (Sphaerotheca fuligena) and apple powdery mildew (Podosphaera leucotricha), alternaria (Alternaria) diseases such as tomato early blight (Alternaria solani) and cabbage black spot (Alternaria brassicae), ball (Ggnaria) diseases such as grape black rot (Guignardia bidwelli), starfish (Venturia) diseases such as apple black spot (Venturia inaequalis), septoria (Septoria) diseases such as glume-end rot (Septoria nodorum) and leaf blight (Septoria triticti), wheat basal rot (Pseudomonas cocorotrichlides) species, botrytis species diseases such as strawberry gray, peach kernel (Monilinia fructicola) diseases, sclerotinia (26) and corn (Pythium) species such as Helicotinia sclerotiorum (spirochet) species (26), and Pneum cosporus species (spirochet) such as Helicoveromyces species (helomyces) and Pneum zebra (spirochete) species (helomyces) such as Helicoverructus sp.sp.sp.sp.sp.sp.32, anthracnose diseases such as black fruit bacteria (Glomerella) or anthracnose genus (Colletotrichum) diseases such as Colletotrichum sorghum (Colletotrichum graminicola) and Colletotrichum citrulli (Colletotrichum); wheat take-all germ (gaeumannomyces graminis), erysiphe (Podosphaera); rhizoctonia (monilia); hook wire genus (Uncinula); globus (Mycosphaerella).
Basidiomycetes, including rust diseases caused by rust (Puccinia), such as Puccinia recondita (Puccinia recondita), puccinia strigosa (Puccinia tricori), puccinia phyllum (Puccinia hordei), puccinia strigosa (pucciniagarami) and Puccinia acuminata (Puccinia ama), puccinia caffei (heceiavastatrix) and Puccinia sojae (phakopsoachyrhizi);
the class Deuteromycetes, including Botrytis; cercospora (Cercospora); alternaria (Alternaria); helminthosporium (Helminthosporium); fusarium (Fusarium); the genus Acremonium (Septoria), the genus Pyricularia (Pyricularia), the genus Rhizoctonia (Rhizoctonia) and the species Rhizoctonia (Rhizoctonia) for example, fusarium oxysporum (Rhizoctonia) and Rhizoctonia cerealis, fusarium (Fusarium) diseases such as Fusarium graminearum (Fusarium), fusarium candidum (Fusarium moniliforme), fusarium oxysporum (Fusarium oxysporum, fusarium moniliforme (Fusarium pseudobulb), eggplant disease (Fusarium roseum) and Fusarium pseudobulb for example, fusarium dahliae (Verticillium pseudobulb), fusarium white fungus (Sclerorotrichliprocarum), fusarium (Rchsporum, and Fusarium pseudolarium.
Oomycetes, including Rhizoctonia (Rhizoctonia); diseases of the genus Phytophthora (Phytophthora), such as Phytophthora infestans (Phytophthora infestans), phytophthora sojae (Phytophthora megasphaerma), phytophthora citri (Phytophthora paramedica), phytophthora camphorata (Phytophthora cinnamomi) and Phytophthora cucurbitae (Phytophthora cucurbitae); diseases of Pythum species such as Pythum species of Pythum species (Pythumaphanidermatum); downy mildew (Peronosporaceae) diseases such as downy mildew (plasmopara viticola); peronospora species (Peronospora) (including peronosporatabacia) and Peronospora parasitica (Peronospora parasitatica); pseudoperonospora (Pseudomonas) pathogens (including Pythium cucumerinum (Pseudomonas) and Bremia (Bremia lactucae), pythum (Pythum) such as Pythumaphanidermatum (Pythumaphanidermatum), plasmopara (Plasmopara).
The compositions of the invention containing pyrazole amides are effective, for example, against phytopathogenic fungi of the following classes: powdery mildew (Erysiphe), puccinia (Puccinia), botrytis (Botrytis), pyricularia (Pyricularia), vermicularia (Helminthosporium), fusarium (Fusarium), septoria (Septoria), cercospora (Cercospora) and Alternaria (Alternaria)) and Rhizoctonia (Rhizoctonia), camelina (henieia).
The composition containing the pyrazole amide compound has obvious activity particularly on powdery mildew (Erysiphe spp.) and can be particularly used for preventing and treating powdery mildew caused by wheat powdery mildew (Erysiphe graminis), grape powdery mildew (Uncinula necator), cucumber powdery mildew (Sphaerotheca fuligena), apple powdery mildew (Podosphaera leucotricha) and the like.
The pyrazole amide compound of the present invention exhibits an enhanced cure and residual control effect on fungal diseases such as powdery mildew of cereals, cucumbers and grapes, and improved leaf systemic properties as compared with conventional fungicides. The composition of the invention has high fungicidal activity in a wide concentration range, and can be used for agriculture without generating harmful phytotoxicity.
Within the scope of the present invention, the useful plants to be protected generally comprise plants of the following classes: grains (wheat, barley, rye, oats, rice, corn, sorghum and related species); beet (sugar beet and fodder beet); pome, stone and berries (apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries and blackberries); leguminous plants (beans, lentils, peas, soybeans); oil plants (rape, mustard, poppy, olives, sunflowers, coconut, castor oil plants, cocoa beans, soyabean plants); cucumbers (pumpkin, cucumber, melon); fiber plants (cotton, flax, hemp, jute); citrus fruits (orange, lemon, grapefruit, mandarin orange); vegetables (spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes, peppers); lauraceae (avocado, cinnamon, camphor) or plants such as tobacco, nuts, coffee, eggplant, sugar cane, tea, pepper, vines, hops, bananas and natural rubber plants, as well as ornamental plants.
The compositions of the invention containing pyrazole amide compounds are particularly important for controlling phytopathogenic fungi on various plants. Including cereals, such as wheat, barley, rye, rice, sorghum; oil crops (e.g., rape, mustard, olives, sunflowers, coconuts, castor oil plants, cocoa beans, peanuts or soybeans, etc.); fiber plants (e.g., cotton, flax, hemp, jute, etc.); citrus fruits (e.g., orange, lemon, grape, chinese citrus, etc.); leguminous plants (e.g., beans, lentils, peas, soybeans); vegetables (lettuce, cabbage, carrot, onion, tomato, potato, green pepper, etc.); fruits such as pome, stone or berries, e.g. apples, pears, plums, peaches, almonds, cherries, strawberries, raspberries, blackberries or gooseberries; corn; tobacco; nuts; coffee; sugarcane; tea; grape vine; bananas, etc.; cucurbits (e.g., pumpkin, cucumber, melon, etc.).
The composition containing the pyrazole amide compound can be used as a foliar bactericide in crop protection, and can also be used as a bactericide for seed dressing and used as a soil bactericide.
The compositions of the invention containing pyrazole amides can be applied to plant pathogenic bacteria and/or their environment, or to plants, plant propagation material and subsequently growing plant organs, soil, materials or spaces, either before or after the plants have been infected.
The compositions of the present invention containing pyrazole amide-based compounds are applied to the plant pathogenic bacteria and/or their environment, or the plant, plant propagation material and subsequently growing plant organs, soil, materials or spaces, in an agronomically effective and substantially non-phytotoxic application amount by means of seed treatment, foliar application, stem application, drenching, instillation, casting, spraying, atomizing, dusting, scattering or fuming, etc.
The composition containing pyrazole amide compounds can be used for protecting seeds, roots and tender shoots of the obtained plants from being invaded by harmful bacteria in soil. Preferably, the roots and shoots of the plant are protected. The seeds may be contacted with an effective amount of the fungicidal composition of the present invention before sowing and/or after germination. The seeds are protected from attack by plant pathogenic bacteria by treating the seeds and the resulting plant roots and shoots are protected.
The application may be performed prior to or during sowing. Methods for applying or treating compositions of the present invention containing pyrazole amide-based compounds to plant propagation materials, particularly seeds, are known in the art. Seed dressing, coating, pelleting, dusting, soaking and in-furrow application methods of plant propagation materials are also known.
Seeds treated with the composition containing pyrazole amide compounds of the invention not only provide protection for the seeds themselves but also for plants growing from the seeds from pathogen attack after emergence. Thus, it may not be necessary to treat the plants directly at or shortly after sowing.
The seed is selected from potato, sunflower, coffee, tobacco, canola, rape, beet, tomato, cucumber, bean, brassica, onion, soybean, wheat, barley, rye, oat, sorghum, peanut, sugarcane, rice, cabbage, cowpea, carrot, cotton, and corn seed. Of particular importance are the treatment of seeds of wheat, barley, rye, oats, corn, cotton, canola, rape, soybean and rice.
The composition containing the pyrazole amide compound is applied to soil before, after or before and after seed germination and/or directly applied to soil contacted with plant roots or soil suitable for plant growth.
The compositions of the invention containing pyrazole amide compounds can also be applied in conventional manner, such as pouring, spraying, spreading, the amount of application varying with the weather conditions or the crop conditions.
Compared with the prior art, the invention has the following beneficial effects:
the composition containing the pyrazole amide compound has good sterilization effect, low medication cost, obvious synergism, good safety to crops and meets the safety requirement of pesticide preparations, and the activity and sterilization effect of the composition are not simple superposition of the activities of the components.
Detailed Description
DETAILED DESCRIPTION OF EMBODIMENT (S) OF INVENTION
Formulation examples
Example 1:
15% fluoxastrobin hydroxylamine-phenylketone wettable powder
10% of fluxapyroxad hydroxylamine, 5% of metrafenone, 5% of alkyl naphthalene sulfonic acid sodium salt formaldehyde polycondensate, 6% of sodium lignin sulfonate, 7% of white carbon black, 0.2% of sodium hexametaphosphate and 100% of kaolin are weighed, and the mixture is subjected to jet milling to prepare 15% of fluxapyroxad hydroxylamine-metrafenone wettable powder.
Example 2:
12% fluoxastrobin hydroxylamine-phenylketone granule
Weighing 4% of fluxapyroxad hydroxylamine, 8% of metrafenone, 7% of diatomite, 5% of calcium lignosulfonate and clay, adding 100% of clay, uniformly mixing the mixture, adding a proper amount of water for kneading, and drying to obtain granules.
Example 3:
20% fluoxastrobin hydroxylamine-metrafenone water dispersible granule
10% fluoxastrobin hydroxylamine, 10% benzene fungus ketone, 6% lignin sulfonate, 7% naphthalene sulfonate polycondensate, 0.4% sodium hexametaphosphate, 3% sodium dodecyl sulfate, 0.3% EDTA and corn starch are weighed to be complemented to 100%. The components are uniformly mixed, then the water dispersible granule is prepared by adopting jet milling, adding water, kneading, extruding, granulating, drying and sieving.
Example 4:
20% fluoxastrobin hydroxylamine-phenylketone suspending agent
8% of fluxapyroxad hydroxylamine, 12% of metrafenone, 4% of polymeric carboxylate, 2% of phenethyl phenol polyoxyethylene ether phosphate, 0.5% of xanthan gum, 0.1% of preservative, 0.2% of defoamer, 2% of glycol, 0.5% of sodium hexametaphosphate, 0.2% of EDTA and water are added to make up to 100%. The components are evenly mixed and then sheared at high speed, and the suspending agent is prepared by sand grinding the grain size of the materials to below 5 microns through a sand mill.
Example 5
18% fluoxastrobin hydroxylamine-metrafenone aqueous emulsion
9% of fluxapyroxad hydroxylamine, 9% of metrafenone, 12% of N-octyl pyrrolidone, 3% of alkylphenol formaldehyde resin polyoxyethylene ether (pesticide emulsion 700 #), 3% of glycol and 0.8% of sodium hexametaphosphate are weighed, and water is added to make up to 100%. The components are uniformly mixed, and then sheared at high speed at the rotating speed of 2700rpm, thus obtaining the aqueous emulsion.
Biological test case
Example 1 Combined virulence of powdery mildew of cucumber with the combination of metrafenone and fluxapyroxad hydroxylamine
Test target: powdery mildew (Erysiphe cucurbitacearum) of cucumber naturally occurs on eastern farm in Kunshan, jiangsu province, and is propagated on potted cucumber by a plant protection technology department bactericide group and stored.
The cucumber variety is selected from Shen Qing No. one, the seedling is cultivated in a seedling cultivation tray, the seedling grows until the first true leaves appear, and the seedling is cultivated in a cultivation tray, 1 plant per tray, and the matrix is mixed soil of DFF farm soil and nutrient soil in a ratio of 4:1.
Preparation of conidium suspension: brushing off spore powder on the diseased leaves with brush, transferring the spores to disease-free cucumber seedling, washing fresh spores with distilled water after the spores are produced again, filtering with double-layer gauze, and making into spore concentration of 1X10 5 The spore suspension was ready for use, per mL of suspension.
And (3) preparation of a medicament: the mother liquor of 10000mg/L is prepared from metrafenone and fluopyram by methanol (analytically pure). Dilute with 0.1% tween 20 in water. The metrafenone and fluopyram are respectively compounded in five proportions of 4:1, 2:1, 1:1, 1:2 and 1:4. A blank of 0.1% Tween 20 was also used.
And (3) medicament treatment: and uniformly spraying the liquid medicine on the front and back surfaces of the blades by adopting a carbon dioxide sprayer under the pressure of 3bar, uniformly wetting the surfaces of the blades, and naturally air-drying the liquid medicine for later use. Every treatment was repeated 4 times, every repetition was 2 pots, totaling 8 pots, 1 plant/pot.
Inoculating and culturing: after spraying for 24 hours, uniformly inoculating the prepared fresh spore suspension to the front surface of the leaf, wherein each plant of cucumber seedlings in 2-leaf period is about 12mL of spore suspension. And (3) after the inoculated cucumber seedlings are dried in the air, transferring the cucumber seedlings into a greenhouse/plant growth chamber in time, keeping the temperature at 20-24 ℃, and alternating light and darkness for 12 hours at the RH of 70%.
Investigation: the onset of each treatment was investigated in stages 14 days after application, and all leaves of all plants were investigated per treatment, with the stages being based on the following criteria (in leaf units). The disease leaf rate of the blank control reaches more than 80 percent.
Level 0: does not cause disease;
stage 1: the area of the disease spots accounts for less than 5% of the area of the whole leaf;
3 stages: the area of the disease spots accounts for 5% -15% of the area of the whole leaf;
5 stages: the area of the disease spots accounts for 15% -25% of the area of the whole leaf;
7 stages: the area of the lesion accounts for 25% -50% of the area of the whole leaf;
stage 9: the area of the lesion accounts for 50-75% of the area of the whole leaf;
11 grades: the area of the disease spots accounts for more than 75% of the area of the whole leaf.
And calculating the disease index and the prevention and treatment effect of each treatment according to the investigation data.
Index of disease condition
The result is calculated according to formula (1) with two decimal places reserved.
Wherein:
X-an index of the condition;
N i -leaf numbers of each stage;
i-relative grade value;
N-investigating the total leaf number.
Prevention and control effect
And (3) calculating according to a formula (2), and reserving two last decimal places as a result.
Wherein:
P-control effect in percent (%);
CK——blank control disease index;
PT-treating an index of the condition of the medicament
Statistical analysis
Regression analysis is carried out on the concentration logarithmic value and the corresponding inhibition rate probability value of each single agent and the mixture with different proportions by DPS, and EC is calculated 50 95% confidence limits.
The synergy of the mixed medicines is evaluated by calculating the synergy coefficient (SR) of the mixture according to the Wadley method, namely SR < 0.5 is antagonism, SR < 0.5 is addition, SR < 1.5 is synergy. The synergy coefficient (SR) is calculated according to the formulas (3) and (4):
wherein:
X 1 EC of the mixture 50 Theoretical value, mg/L;
P A -percentage of a in the mix,%;
P B -percentage of B in the mix,%;
AEC of a in the mixture 50 Value, mg/L;
BEC of B in the mixture 50 Value, mg/L.
Wherein:
SR-the synergistic coefficient of the mixture;
X 1 EC of the mixture 50 Theoretical value, mg/L;
X 2 EC of the mixture 50 Actual value, mg/L;
table 1 toxicity test of metrafenone and fluxapyroxad hydroxylamine against powdery mildew of cucumber
From Table 1, it is known that the combination of the metrafenone and the fluxapyroxad hydroxylamine has the synergistic coefficient of more than 1.5 on powdery mildew of cucumber within the range of the ratio of 1:4-4:1, shows a synergistic effect and has a very strong inhibiting effect on powdery mildew of cucumber. Wherein when the proportion of the metrafenone to the fluxapyroxad hydroxylamine is 1: 4. the synergy is particularly obvious at the time of 1:2 and 1:1, and the synergy coefficient is more than 9.
The above description is only of the preferred embodiments of the present invention and is not intended to limit the present invention, but various modifications, substitutions, improvements, etc. can be made by those skilled in the art, and are intended to be included in the scope of the present invention.

Claims (11)

1. The composition containing the pyrazole amide compound is characterized by comprising fluxapyroxad hydroxylamine and metrafenone, wherein the weight ratio of the fluxapyroxad hydroxylamine to the metrafenone is 20:1-1:20.
2. Composition containing pyrazole amide compounds according to claim 1, characterized in that the weight ratio of fluxapyroxad hydroxylamine and metrafenone is 20:1-1:10, preferably 20:1-1:5, preferably 15:1-1:5, further preferably 10:1-1:5, more preferably 5:1-1:5, more preferably 4:1-1:4, more preferably 4:1-1:2, more preferably 4:1-1:1.
3. The pyrazole amide-based compound-containing composition according to claim 1, wherein the composition further comprises a filler and/or a surfactant.
4. The composition containing pyrazole amide compounds according to claim 1, wherein the composition is in the form of an aqueous suspension, an emulsifiable concentrate, a suspension, a seed treatment solution, a seed treatment dry powder, a seed treatment emulsion, water dispersible granules, a suspension seed coating, a suspension emulsion, a wettable powder, an aqueous emulsion, a granule, a dry suspension, a microcapsule suspension, an electrostatic oil, an ultra-low volume liquid, or a microparticle.
5. Use of a composition containing pyrazole amide compound according to claim 1 for preventing or controlling fungal diseases.
6. Use of a composition containing pyrazole amide compounds according to claim 1 for the prevention or control of fungal diseases caused by Erysiphe (Erysiphe), puccinia (Puccinia), botrytis (Botrytis), pyricularia (Pyricularia), vermicularia (helminthiosporium), fusarium (Fusarium), septoria (Septoria), cercospora (Cercospora) and Alternaria (Alternaria) and Rhizoctonia (Rhizoctonia), camelina (hecileia).
7. Use of a composition containing pyrazole amide compounds according to claim 1 for preventing or controlling fungal diseases caused by Erysiphe (Erysiphe spp.).
8. The composition containing pyrazole amide compound according to claim 1, which is used for preventing or controlling powdery mildew caused by powdery mildew (Erysiphe graminis), powdery mildew (Uncinula necator), powdery mildew (Sphaerotheca fuligena) of cucumber and powdery mildew (Podosphaera leucotricha) of apple.
9. The pyrazole amide-containing composition according to claim 1, which is useful for protecting seeds, roots and shoots of plants from attack by soil-pathogenic fungi.
10. A method for preventing or controlling the attack by phytopathogenic fungi on plants, plant parts, plant propagation material and subsequently growing plant organs, which comprises applying the composition comprising a pyrazole amide-based compound according to claim 1 in an agronomically effective and substantially non-phytotoxic application amount to the plants, plant parts, plant propagation material or the soil or cultivation medium in which the plants are growing or are desired to grow, in a seed treatment, foliar application, stem application, soaking, instillation, casting, spraying, dusting, scattering or fuming process.
11. A method according to claim 10, comprising applying the composition comprising a pyrazole amide-based compound according to claim 1 to a plant, plant part, plant propagation material or soil or cultivation medium in which the plant is growing or is in need of growth, either before or after infestation of the plant by pathogenic fungi.
CN202210077957.0A 2022-01-24 2022-01-24 Composition containing pyrazole amide compound and application of composition in preventing or controlling powdery mildew Pending CN116491507A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114766495A (en) * 2022-05-05 2022-07-22 青岛滕润翔检测评价有限公司 Sterilization composition containing penconazole-containing acylhydroxylamine and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114766495A (en) * 2022-05-05 2022-07-22 青岛滕润翔检测评价有限公司 Sterilization composition containing penconazole-containing acylhydroxylamine and application thereof
CN114766495B (en) * 2022-05-05 2024-03-08 青岛滕润翔检测评价有限公司 Sterilization composition containing fluxapyroxad hydroxylamine and application thereof

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