CN116474054A - Traditional Chinese medicine composition for improving obesity and constipation as well as preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for improving obesity and constipation as well as preparation method and application thereof Download PDF

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CN116474054A
CN116474054A CN202310657098.7A CN202310657098A CN116474054A CN 116474054 A CN116474054 A CN 116474054A CN 202310657098 A CN202310657098 A CN 202310657098A CN 116474054 A CN116474054 A CN 116474054A
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parts
chinese medicine
traditional chinese
medicine composition
constipation
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李阳坤
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Genuine Hebei Technology Co ltd
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Genuine Hebei Technology Co ltd
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23FCOFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00Tea; Tea substitutes; Preparations thereof
    • A23F3/34Tea substitutes, e.g. matè; Extracts or infusions thereof
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Abstract

The invention discloses a traditional Chinese medicine composition for improving obesity and constipation, and a preparation method and application thereof, wherein the traditional Chinese medicine composition comprises the following components: 6-10 parts of red ginseng, 10-20 parts of poria cocos, 10-20 parts of rhizoma polygonati, 10-20 parts of radish seed, 10-20 parts of perilla fruit, 10-20 parts of yellow mustard seed, 15-25 parts of fructus cannabis, 8-12 parts of lophatherum gracile, 8-12 parts of sea buckthorn leaf, 8-12 parts of mulberry leaf, 10-20 parts of millettia speciosa champ, 8-12 parts of burdock root, 10-20 parts of semen cassiae, 10-20 parts of dandelion, 5-10 parts of fructus amomi, 8-12 parts of scorched hawthorn fruit, 8-12 parts of eucommia male flower, 10-20 parts of white kidney bean, 10-20 parts of calcined lotus leaf, 10-20 parts of fructus alpiniae oxyphyllae, 8-12 parts of liquorice, 10-20 parts of rhizoma polygonati officinalis, 6-10 parts of gardenia, 8-12 parts of red rose with heavy petals, 8-12 parts of medlar, 8-12 parts of fingered citron and 8-12 parts of citron; the traditional Chinese medicine composition has the effects of strengthening spleen and stomach, strengthening kidney and body, relaxing bowel, reducing blood fat, promoting intestinal peristalsis and the like, can promote metabolism of organisms, can remarkably improve obesity and constipation, has remarkable effect, and has no toxic or side effect on human bodies.

Description

Traditional Chinese medicine composition for improving obesity and constipation as well as preparation method and application thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for improving obesity and constipation, and a preparation method and application thereof.
Background
Obesity refers to a condition that is caused by excessive accumulation of fat, especially triglycerides, in the body, as well as a degree of apparent overweight and excessive fat layer thickness. Excessive body fat accumulation due to excessive food intake or altered body metabolism results in excessive weight gain and causes pathological, physiological changes or latency in the human body. Obesity can increase the risk of diabetes, cardiovascular disease, hypertension, hyperlipidemia, fatty liver, various tumors, metabolic disorders, etc.
Constipation and obesity are a common disease of modern people and have become one of the major diseases affecting social development. Constipation can increase the absorption of human body to energy substances in food, and cause obesity, and seriously, can prolong the action time of toxic and harmful substances on intestinal wall, and cause various diseases such as hypertension, hyperlipidemia, diabetes, cancer, etc.
At present, most of the existing weight-losing medicines are chemical substances, have certain dependence on medicines and have certain side effects on bodies.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition for improving obesity and constipation, and a preparation method and application thereof.
In order to achieve the above object of the present invention, the following technical solutions are specifically adopted:
the invention provides a traditional Chinese medicine composition for improving obesity and constipation, which comprises the following components in parts by weight:
6-10 parts of red ginseng, 10-20 parts of poria cocos, 10-20 parts of rhizoma polygonati, 10-20 parts of radish seed, 10-20 parts of perilla fruit, 10-20 parts of yellow mustard seed, 15-25 parts of fructus cannabis, 8-12 parts of lophatherum gracile, 8-12 parts of sea buckthorn leaf, 8-12 parts of mulberry leaf, 10-20 parts of millettia speciosa champ, 8-12 parts of burdock root, 10-20 parts of semen cassiae, 10-20 parts of dandelion, 5-10 parts of fructus amomi, 8-12 parts of scorched hawthorn fruit, 8-12 parts of eucommia male flower, 10-20 parts of white kidney bean, 10-20 parts of calcined lotus leaf, 10-20 parts of fructus alpiniae oxyphyllae, 8-12 parts of liquorice, 10-20 parts of rhizoma polygonati officinalis, 6-10 parts of gardenia, 8-12 parts of red rose with heavy petals, 8-12 parts of medlar, 8-12 parts of fingered citron and 8-12 parts of citron.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight:
8 parts of red ginseng, 15 parts of poria cocos, 15 parts of rhizoma polygonati, 15 parts of radish seed, 15 parts of perilla seed, 15 parts of semen brassicae, 20 parts of fructus cannabis, 10 parts of lophatherum gracile, 10 parts of sea buckthorn leaves, 10 parts of mulberry leaves, 15 parts of radix millettiae speciosa, 10 parts of burdock roots, 15 parts of semen cassiae, 15 parts of dandelion, 8 parts of fructus amomi, 10 parts of scorched hawthorn fruits, 10 parts of eucommia stamina flowers, 15 parts of white kidney beans, 15 parts of calcined lotus leaves, 15 parts of fructus alpiniae oxyphyllae, 10 parts of liquorice, 15 parts of rhizoma polygonati officinalis, 8 parts of gardenia, 10 parts of red roses with heavy petals, 10 parts of medlar, 10 parts of fingered citron and 10 parts of citron.
The second aspect of the invention provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(a) Weighing the components according to the weight parts;
(b) Respectively crushing and mixing the raw materials to obtain a mixture;
(c) Adding ethanol water solution into the mixture, reflux extracting, filtering, concentrating to paste, oven drying, and pulverizing to obtain the Chinese medicinal composition.
Preferably, the mass ratio of the ethanol aqueous solution to the mixture is (3-5) to 1; the concentration of the ethanol aqueous solution is 30% -50%.
Preferably, the number of times of reflux extraction is 2-4, and the time of each reflux extraction is 2-4 hours.
The third aspect of the invention provides application of the traditional Chinese medicine composition in preparing traditional Chinese medicine preparations for improving obesity and constipation.
Preferably, the dosage forms of the traditional Chinese medicine preparation comprise tablets, granules, tea and capsules.
The fourth aspect of the invention provides a traditional Chinese medicine preparation with the effects of improving obesity and constipation, which comprises the traditional Chinese medicine composition and pharmaceutically acceptable auxiliary materials.
Preferably, the auxiliary material comprises at least one of sorbitol, maltodextrin and sucralose.
Compared with the prior art, the invention has the beneficial effects that at least:
according to the invention, the specific raw materials are combined according to the property of the medicine property of each raw material and the physicochemical property and pharmacological activity of the effective components of each raw material, the specific dosage of each raw material is limited, the synergistic effect of each raw material is realized, the mutual promotion of the medicine effect is exerted, so that the traditional Chinese medicine composition has the effects of strengthening spleen and stomach, strengthening kidney and body, relaxing bowel, reducing blood fat, promoting intestinal peristalsis and the like, further can promote metabolism of organisms, improves obesity and constipation, has remarkable effect, and has no toxic or side effect on human bodies.
Detailed Description
Embodiments of the technical scheme of the present invention will be described in detail below with reference to the embodiments. The following examples are only for more clearly illustrating the technical aspects of the present invention, and thus are merely examples, and are not intended to limit the scope of the present invention.
It is noted that unless otherwise indicated, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this invention pertains.
The red ginseng adopted in the following examples is prepared by processing artificially planted ginseng for 5 years or less.
Example 1
The embodiment provides a traditional Chinese medicine composition for improving obesity and constipation, which comprises the following components in parts by weight:
6 parts of red ginseng, 10 parts of poria cocos, 20 parts of rhizoma polygonati, 10 parts of radish seed, 20 parts of perilla fruit, 10 parts of semen brassicae, 25 parts of fructus cannabis, 8 parts of lophatherum gracile, 8 parts of sea buckthorn leaves, 12 parts of mulberry leaves, 20 parts of radix millettiae speciosa, 8 parts of burdock roots, 10 parts of semen cassiae, 20 parts of dandelion, 5 parts of fructus amomi, 8 parts of scorched hawthorn fruits, 12 parts of eucommia male flowers, 10 parts of white kidney beans, 20 parts of calcined lotus leaves, 10 parts of fructus alpiniae oxyphyllae, 12 parts of liquorice, 20 parts of rhizoma polygonati officinalis, 6 parts of gardenia, 8 parts of red roses with heavy petals, 12 parts of medlar, 8 parts of fingered citron and 12 parts of citron.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(a) Weighing the components according to the weight parts;
(b) Respectively crushing and mixing the raw materials to obtain a mixture;
(c) Adding ethanol water solution into the mixture, performing reflux extraction, filtering, concentrating to paste, oven drying, and pulverizing to obtain the Chinese medicinal composition;
wherein the mass ratio of the ethanol aqueous solution to the mixture is 3:1; the concentration of the aqueous ethanol solution was 30%.
The number of reflux extractions was 2 and the time per reflux extraction was 4 hours.
Example 2
The embodiment provides a traditional Chinese medicine composition for improving obesity and constipation, which comprises the following components in parts by weight:
10 parts of red ginseng, 20 parts of poria cocos, 10 parts of rhizoma polygonati, 20 parts of radish seed, 10 parts of perilla fruit, 20 parts of semen brassicae, 15 parts of fructus cannabis, 12 parts of lophatherum gracile, 12 parts of sea buckthorn leaves, 8 parts of mulberry leaves, 10 parts of radix millettiae speciosa, 12 parts of burdock roots, 20 parts of semen cassiae, 10 parts of dandelion, 10 parts of fructus amomi, 12 parts of scorched hawthorn fruits, 8 parts of eucommia male flowers, 20 parts of white kidney beans, 10 parts of calcined lotus leaves, 20 parts of fructus alpiniae oxyphyllae, 8 parts of liquorice, 10 parts of rhizoma polygonati officinalis, 10 parts of gardenia, 12 parts of red roses with heavy petals, 8 parts of medlar, 12 parts of fingered citron and 8 parts of citron.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(a) Weighing the components according to the weight parts;
(b) Respectively crushing and mixing the raw materials to obtain a mixture;
(c) Adding ethanol water solution into the mixture, performing reflux extraction, filtering, concentrating to paste, oven drying, and pulverizing to obtain the Chinese medicinal composition;
wherein the mass ratio of the ethanol aqueous solution to the mixture is 5:1; the concentration of the aqueous ethanol solution was 50%.
The number of reflux extractions was 4 and the time per reflux extraction was 2 hours.
Example 3
The embodiment provides a traditional Chinese medicine composition for improving obesity and constipation, which comprises the following components in parts by weight:
8 parts of red ginseng, 15 parts of poria cocos, 15 parts of rhizoma polygonati, 15 parts of radish seed, 15 parts of perilla seed, 15 parts of semen brassicae, 20 parts of fructus cannabis, 10 parts of lophatherum gracile, 10 parts of sea buckthorn leaves, 10 parts of mulberry leaves, 15 parts of radix millettiae speciosa, 10 parts of burdock roots, 15 parts of semen cassiae, 15 parts of dandelion, 8 parts of fructus amomi, 10 parts of scorched hawthorn fruits, 10 parts of eucommia stamina flowers, 15 parts of white kidney beans, 15 parts of calcined lotus leaves, 15 parts of fructus alpiniae oxyphyllae, 10 parts of liquorice, 15 parts of rhizoma polygonati officinalis, 8 parts of gardenia, 10 parts of red roses with heavy petals, 10 parts of medlar, 10 parts of fingered citron and 10 parts of citron.
The preparation method of the traditional Chinese medicine composition comprises the following steps:
(a) Weighing the components according to the weight parts;
(b) Respectively crushing and mixing the raw materials to obtain a mixture;
(c) Adding ethanol water solution into the mixture, performing reflux extraction, filtering, concentrating to paste, oven drying, and pulverizing to obtain the Chinese medicinal composition;
wherein the mass ratio of the ethanol aqueous solution to the mixture is 4:1; the concentration of the aqueous ethanol solution was 40%.
The number of reflux extractions was 3, and the time per reflux extraction was 3 hours.
Example 4
This example is a Chinese medicinal preparation having the effect of improving obesity and constipation, which is prepared by mixing 10 parts of the Chinese medicinal composition of example 1 with 70 parts of maltodextrin, 10 parts of sorbitol and 10 parts of sucralose, granulating, drying, adding magnesium stearate, and tabletting with 0.5g each tablet.
Example 5
This example is a Chinese medicinal preparation having the effect of improving obesity and constipation, which is prepared by mixing 10 parts of the Chinese medicinal composition of example 2 with 70 parts of maltodextrin, 10 parts of sorbitol and 10 parts of sucralose, granulating, drying, adding magnesium stearate, and tabletting with 0.5g each tablet.
Example 6
This example is a Chinese medicinal preparation having the effect of improving obesity and constipation, which is prepared by mixing 10 parts of the Chinese medicinal composition of example 3 with 70 parts of maltodextrin, 10 parts of sorbitol and 10 parts of sucralose, granulating, drying, adding magnesium stearate, and tabletting with 0.5g each tablet.
Experimental example
Respectively obtaining the traditional Chinese medicine preparation of the example 6;
56 patients with constipation are characterized in that the number of times of defecation of each patient is less than or equal to 3 times per week; then taking the traditional Chinese medicine preparation prepared in the embodiment 6 of the invention respectively; the administration method comprises the following steps: 3 times a day, 4 tablets each time; is taken for 6 weeks. Then, the number of times of stool in one week after the recording; the recording results are shown in Table 1;
TABLE 1
Number of times of defecation Example 6
Less than 3 times 2
4 times 4 people
5 times 13 persons
More than 6 times 37 person
As shown in table 1, the traditional Chinese medicine composition prepared in the embodiment of the application can significantly improve constipation, and further can improve obesity caused by constipation.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention, and are intended to be included within the scope of the appended claims and description.

Claims (9)

1. The traditional Chinese medicine composition for improving obesity and constipation is characterized by comprising the following components in parts by weight:
6-10 parts of red ginseng, 10-20 parts of poria cocos, 10-20 parts of rhizoma polygonati, 10-20 parts of radish seed, 10-20 parts of perilla fruit, 10-20 parts of yellow mustard seed, 15-25 parts of fructus cannabis, 8-12 parts of lophatherum gracile, 8-12 parts of sea buckthorn leaf, 8-12 parts of mulberry leaf, 10-20 parts of millettia speciosa champ, 8-12 parts of burdock root, 10-20 parts of semen cassiae, 10-20 parts of dandelion, 5-10 parts of fructus amomi, 8-12 parts of scorched hawthorn fruit, 8-12 parts of eucommia male flower, 10-20 parts of white kidney bean, 10-20 parts of calcined lotus leaf, 10-20 parts of fructus alpiniae oxyphyllae, 8-12 parts of liquorice, 10-20 parts of rhizoma polygonati officinalis, 6-10 parts of gardenia, 8-12 parts of red rose with heavy petals, 8-12 parts of medlar, 8-12 parts of fingered citron and 8-12 parts of citron.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight:
8 parts of red ginseng, 15 parts of poria cocos, 15 parts of rhizoma polygonati, 15 parts of radish seed, 15 parts of perilla seed, 15 parts of semen brassicae, 20 parts of fructus cannabis, 10 parts of lophatherum gracile, 10 parts of sea buckthorn leaves, 10 parts of mulberry leaves, 15 parts of radix millettiae speciosa, 10 parts of burdock roots, 15 parts of semen cassiae, 15 parts of dandelion, 8 parts of fructus amomi, 10 parts of scorched hawthorn fruits, 10 parts of eucommia stamina flowers, 15 parts of white kidney beans, 15 parts of calcined lotus leaves, 15 parts of fructus alpiniae oxyphyllae, 10 parts of liquorice, 15 parts of rhizoma polygonati officinalis, 8 parts of gardenia, 10 parts of red roses with heavy petals, 10 parts of medlar, 10 parts of fingered citron and 10 parts of citron.
3. The method for preparing the traditional Chinese medicine composition according to claim 1 or 2, comprising the following steps:
(a) Weighing the components according to the weight parts;
(b) Respectively crushing and mixing the raw materials to obtain a mixture;
(c) Adding ethanol water solution into the mixture, reflux extracting, filtering, concentrating to paste, oven drying, and pulverizing to obtain the Chinese medicinal composition.
4. The preparation method according to claim 3, wherein the mass ratio of the aqueous ethanol solution to the mixture is (3-5) to 1; the concentration of the ethanol aqueous solution is 30% -50%.
5. The method according to claim 3, wherein the number of times of the reflux extraction is 2 to 4, and the time of each reflux extraction is 2 to 4 hours.
6. The use of the Chinese medicinal composition according to claim 1 or 2 for preparing a Chinese medicinal preparation for improving obesity and constipation.
7. The use according to claim 6, wherein the dosage forms of the Chinese medicinal preparation comprise tablets, granules, tea and capsules.
8. A traditional Chinese medicine preparation with the efficacy of improving obesity and constipation, which is characterized by comprising the traditional Chinese medicine composition of claim 1 or 2 and pharmaceutically acceptable auxiliary materials.
9. The traditional Chinese medicine preparation according to claim 8, wherein the auxiliary materials comprise at least one of sorbitol, maltodextrin and sucralose.
CN202310657098.7A 2023-06-05 2023-06-05 Traditional Chinese medicine composition for improving obesity and constipation as well as preparation method and application thereof Pending CN116474054A (en)

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