CN116473857A

CN116473857A - Oil core coagulated bead, preparation method and cosmetics

Info

Publication number: CN116473857A
Application number: CN202310352324.0A
Authority: CN
Inventors: 孙怀庆; 裴运林; 赵芃; 聂艳峰; 江川霞; 肖湲
Original assignee: Guangdong Marubi Biological Technology Co Ltd
Current assignee: Guangdong Marubi Biological Technology Co Ltd
Priority date: 2023-04-03
Filing date: 2023-04-03
Publication date: 2023-07-25

Abstract

The application relates to the field of cosmetics, and relates to an oil core gel bead, a preparation method and cosmetics. The present application provides an oil core gel bead comprising an outer phase and an inner phase; the outer phase comprises: calcium alginate; the internal phase comprises: grease and oil-soluble actives; the oil is caprylic acid/capric acid/succinic acid triglyceride, and squalane; the oil-soluble active substance is ubiquinone, tocopherol, radix Arnebiae extract; the internal phase comprises the following components in percentage by mass: 60-90% of caprylic acid/capric acid/succinic acid triglyceride, 5-30% of triglyceride (ethyl caproic acid) ester, 2.5-30% of squalane and the balance of oil-soluble active substances. According to the oil core gel bead, the caprylic acid/capric acid/succinic acid triglyceride is introduced into the inner phase, so that the oil core gel bead with excellent sedimentation and stable accumulation can be formed, and the problems of influence on subsequent experiments or production caused by floating and oil slick of the oil core coated gel bead are effectively solved.

Description

Oil core coagulated bead, preparation method and cosmetics

Technical Field

The application relates to the field of cosmetics, in particular to an oil core gel bead, a preparation method and cosmetics.

Background

The microcapsule/gel bead coating technology is a technology which uses natural or synthetic polymer materials to form one or more layers of semi-permeable or airtight outer phases, uses solid or liquid and the like as inner phases to coat, and relates to multidisciplinary and multi-field intersection. The technology is widely applied to various industries such as printing, medicines, foods and the like.

However, the technology has many problems of relatively complex production operation, limited available raw materials/systems, transportation crushing/deformation, skin feel requirement, cost control and the like, and is still immature in application in the cosmetic field and is not widely applied at present.

By utilizing the biphase wrapping technology, the effects of keeping fresh, slowly releasing the active substances and the like can be achieved while the visual sense pleasure is improved, so that the application of the technology in the cosmetic industry is promoted to have important significance.

The microcapsule/bead encapsulation technology can be broadly divided into chemical, physical and physicochemical methods according to the preparation route. The preparation methods commonly used in the cosmetic field are: dripping method, spraying method, stirring granulation method, etc. However, the oil core coagulated beads prepared by the prior preparation processes often have the problems of accumulation floating on the upper layer of the liquid surface, leakage of the oil core and the like.

Disclosure of Invention

The embodiment of the application aims at providing an oil core gel bead, a preparation method and cosmetics.

In a first aspect, the present application provides an oil core bead comprising an outer phase and an inner phase; the outer phase comprises: calcium alginate; the internal phase comprises: oils and fats, and oil-soluble actives; the oil is caprylic acid/capric acid/succinic acid triglyceride, and squalane; the oil-soluble active substance is ubiquinone, tocopherol, radix Arnebiae extract; the internal phase comprises, by mass, 60-90% of caprylic/capric/succinic triglyceride, 5-30% of triglyceride (ethyl caproic acid) ester, 2.5-30% of squalane, and the balance of oil-soluble active substances.

According to the oil core gel bead, the caprylic acid/capric acid/succinic acid triglyceride is introduced into the inner phase, so that the oil core gel bead with excellent sedimentation and stable accumulation can be formed, and the problems of influence on subsequent experiments or production caused by floating and oil slick of the oil core coated gel bead are effectively solved.

In other embodiments of the present application, the outer phase further comprises: water, humectant, preservative, thickener and solid agent;

optionally, the humectant comprises polyols.

In other embodiments of the present application, the moisturizer comprises: at least one of glycerol, dipropylene glycol, PEG/PPG-14/7 dimethyl ether;

the preservative comprises phenoxyethanol.

Optionally, the thickener and the solidifying agent comprise at least one of xanthan gum, gellan gum, agar.

In other embodiments of the present application, the raw materials of the external phase include, in mass percent: glycerin 1.0-10.0%, dipropylene glycol 1.0-10.0%, phenoxyethanol 0.1-1.0%, PEG/PPG-14/7 dimethyl ether 0.5-5.0%, xanthan gum 0-0.5%, gellan gum 0.1-1.0%, agar 0-1.0%, sodium alginate 0.4-0.8%, calcium ion 0.2-0.5%, and water in balance.

In other embodiments of the present application, the internal phase further comprises: grease and oil-soluble actives;

optionally, the oil is selected from caprylic acid/capric acid/succinic acid triglyceride, and squalane; the oil-soluble actives include: ubiquinone, tocopherol, arnebia root extract.

In other embodiments of the present application, the wall forming material of the outer phase comprises: sodium alginate and calcium ions; the mass ratio of the sodium alginate of the external phase to the calcium ions is (0.4-0.8): (0.2-0.5).

In other embodiments of the present application, the internal phase comprises, in mass percent: 60-90% of caprylic acid/capric acid/succinic acid triglyceride, 5-30% of triglyceride (ethyl caproic acid) ester and 2.5-30% of squalane; the balance being oil-soluble active;

optionally, the internal phase comprises, in mass percent: 60-90% of caprylic acid/capric acid/succinic acid triglyceride, 5-30% of triglyceride (ethyl caproic acid) ester and 2.5-30% of squalane; the balance being oil-soluble active.

In other embodiments of the present application, the oil-soluble actives include: ubiquinone, tocopherol, or labile oil soluble actives; optionally, the labile oil-soluble active is selected from vegetable oils and fats that are susceptible to oxidative decomposition; alternatively, the labile oil-soluble active is selected from arnebia root extract, retinol and derivatives thereof.

In a second aspect, the present application provides a method of preparing an oil core coagulated bead comprising:

uniformly mixing caprylic acid/capric acid/succinic acid triglyceride, other grease and oil-soluble active substances to obtain an internal phase raw material liquid;

the inner phase feed solution and the outer phase feed solution comprising alginate are simultaneously drained into the calcium salt solution.

In a third aspect, the present application provides a cosmetic comprising the oil core globules provided in the first aspect above.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings that are needed in the embodiments will be briefly described below, it being understood that the following drawings only illustrate some embodiments of the present application and therefore should not be considered limiting the scope, and that other related drawings may be obtained according to these drawings without inventive effort for a person skilled in the art.

FIG. 1 is an external view (side view) of the oil core beads prepared in example 3 at a first view angle;

fig. 2 is an external view (side view) of the first view angle of comparative example 1.

FIG. 3 is an external view (top view) of the oil core beads prepared in example 3 from a second perspective;

FIG. 4 is a microstructure of the oil core beads prepared in example 3.

Detailed Description

For the purposes of making the objects, technical solutions and advantages of the embodiments of the present application more clear, the technical solutions in the embodiments of the present application will be clearly and completely described below, and it is obvious that the described embodiments are some embodiments of the present application, but not all embodiments.

Thus, the following detailed description of the embodiments of the present application is not intended to limit the scope of the application, as claimed, but is merely representative of selected embodiments of the application. All other embodiments, which can be made by one of ordinary skill in the art based on the embodiments herein without making any inventive effort, are intended to be within the scope of the present application.

Because the density of grease is smaller than that of water, when the content of the wrapped oil core is higher, the inventor discovers that the problems of accumulation on the upper layer of the reaction liquid, leakage of the oil core and the like often occur in the preparation process of the oil-in-oil gel beads such as a dripping method, a spraying method and the like which are conventionally used by the existing calcium alginate and the like, and the subsequent dripping production flow is influenced.

Embodiments of the present application provide an oil core bead comprising an outer phase and an inner phase; the outer phase comprises: calcium alginate; the internal phase comprises: oils and fats, and oil-soluble actives; the oil is caprylic acid/capric acid/succinic acid triglyceride, triglyceride and tri (ethylhexanoic acid) ester; the oil-soluble active substance is ubiquinone, tocopherol, and radix Arnebiae extract; the internal phase comprises, by mass, 60-90% of caprylic/capric/succinic triglyceride, 5-30% of triglyceride (ethyl caproic acid) ester, 2.5-30% of squalane, and the balance of oil-soluble active substances.

According to the oil core gel bead, the caprylic acid/capric acid/succinic acid triglyceride is introduced into the internal phase (oil core/oil phase), and the caprylic acid/capric acid/succinic acid triglyceride is introduced into the internal phase, so that the oil core gel bead with excellent sedimentation and stable accumulation can be formed, and the problems of influence on subsequent experiments or production caused by floating of the oil core coated gel bead and floating oil are effectively solved.

Further, in other embodiments of the present application, the wall forming raw materials of the outer phase include: sodium alginate and calcium ions; sodium alginate and calcium ion (0.4-0.8): (0.2-0.5).

Further, in some embodiments of the present application, the above-mentioned external phase further includes: water, a humectant, a preservative, a thickener and a solid.

Further, in some embodiments of the present application, the humectant described above includes polyols.

Further, in some embodiments of the present application, the moisturizer described above includes: at least one of glycerol, dipropylene glycol, PEG/PPG-14/7 dimethyl ether.

The preservative comprises phenoxyethanol.

Illustratively, in some embodiments of the present application, the humectants described above are selected from glycerin and dipropylene glycol; or in some embodiments of the present application, the humectant described above is selected from glycerin, dipropylene glycol, and PEG/PPG-14/7 dimethyl ether.

Further, in some embodiments of the present application, the preservative is selected from phenoxyethanol.

Further, in some embodiments of the present application, the thickener and the solidifying agent are selected from at least one of xanthan gum, gellan gum, agar.

By controlling the mass ratio of sodium alginate and calcium ions within the above-described range, excellent formability of the oil core globules can be obtained.

Illustratively, the mass ratio of sodium alginate to calcium ions in the outer phase material is 0.4:0.2 to 0.5; or 0.5:0.2 to 0.5; or 0.6:0.2 to 0.5; or 0.7:0.2 to 0.5; or 0.8:0.2 to 0.5.

Further, in some embodiments of the present application, the raw materials of the external phase include, in mass percent: glycerin 1.0-10.0%, dipropylene glycol 1.0-10.0%, phenoxyethanol 0.1-1.0%, PEG/PPG-14/7 dimethyl ether 0.5-5.0%, xanthan gum 0-0.5%, gellan gum 0.1-1.0%, agar 0-1.0%, sodium alginate 0.4-0.8%, calcium ion 0.2-0.5%, and water in balance.

Further alternatively, in some embodiments of the present application, the raw materials of the external phase include, in mass percent: 2.0 to 8.0 percent of glycerin, 2.0 to 8.0 percent of dipropylene glycol, 0.2 to 0.9 percent of phenoxyethanol, 0.6 to 4.0 percent of PEG/PPG-14/7 dimethyl ether, 0.1 to 0.3 percent of xanthan gum, 0.2 to 0.9 percent of gellan gum, 0.1 to 0.9 percent of agar, 0.5 to 0.7 percent of sodium alginate, 0.3 to 0.4 percent of calcium ions and the balance of water.

Illustratively, in some embodiments of the present application, the raw materials of the external phase comprise, in mass percent:

glycerol 1.5%, 2.0%, 3%, 4%, 5%, 6%, 7%, 8% or 9%;

dipropylene glycol 1.5%, 2.0%, 3%, 4%, 5%, 6%, 7%, 8%, or 9%;

phenoxyethanol 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, or 0.8%;

PEG/PPG-14/7 dimethyl 1%, 2%, 3%, 4% or 4.5%;

xanthan gum 0.1%, 0.2%, 0.3% or 0.4%;

gellan gum 0.12%, 0.15%, 0.2%, 0.3%, 0.4%, 0.5%, or 0.8%;

agar 0.1%, 0.5%, 0.6%, 0.7%, 0.8% or 0.9%;

sodium alginate 0.5%, 0.6%, 0.7% or 0.8%;

0.2%, 0.3%, 0.4% or 0.5% of calcium ions.

In some embodiments of the present application, the internal phase comprises: grease and oil-soluble actives.

In some embodiments of the present application, the lipid is selected from caprylic/capric/succinic triglyceride, triglyceride tri (ethylhexanoate), squalane.

In some embodiments of the present application, the internal phase comprises, in mass percent: 60-90% of caprylic acid/capric acid/succinic acid triglyceride, 5-30% of triglyceride (ethyl caproic acid) ester and 2.5-30% of squalane; the balance being oil-soluble active.

Illustratively, in some embodiments of the present application, the internal phase comprises:

60%, 70%, 80%, 85% or 90% caprylic/capric/succinic triglyceride;

6%, 7%, 8%, 10%, 20% or 30% of tris (ethylhexanoate) glyceride;

3%, 7%, 8%, 10%, 20% or 30% squalane;

the balance being oil-soluble active.

Further, in some embodiments of the present application, the oil-soluble active includes: ubiquinone, tocopherol, or labile oil soluble actives; optionally, the labile oil-soluble active is selected from vegetable oils and fats that are susceptible to oxidative decomposition; alternatively, the labile oil-soluble active is selected from arnebia root extract, retinol and derivatives thereof.

In a second aspect, some embodiments of the present application provide a method for preparing an oil core gel bead, comprising:

Further, in some embodiments of the present application, 1000±200 μm oil core-coated beads excellent in sedimentation were prepared by a microfluidic technique molding and a dripping method using a calcium alginate system by adding the components caprylic/capric/succinic triglyceride.

Specifically, the method comprises the following steps:

(1) Configuring a first phase: according to the proportion of any of the previous embodiments, deionized water, glycerol, dipropylene glycol, xanthan gum, gellan gum, sodium alginate, phenoxyethanol, PEG/PPG-14/7 dimethyl ether and agar are mixed, then heated to above 90 ℃, kept for 20min, and homogenized at 8000rpm for 2min;

(2) Configuring a second phase: mixing caprylic/capric/succinic triglyceride, tri (ethylhexanoic acid) ester, squalane, ubiquinone, tocopherol, and radix Arnebiae extract according to the proportion of any embodiment, and stirring to uniformity;

(3) And (3) configuring a third phase: calcium chloride or calcium lactate was formulated as a 0.3% (w/w) soak.

(4) The first phase and the second phase are drained into a calcium chloride or calcium lactate solution of the third phase by means of pump force by adopting a T-shaped pipe, so that oil core-coated gel beads are formed.

In addition to the dropping method of the oil core coagulated beads, the other optional embodiments of the present application are also applicable to a preparation method of oil core microcapsules such as an O/W/O microcapsule extraction method in a stirring granulation method, and can increase the sedimentation rate, reduce the proportion of oil-containing coagulated beads at a water-oil intersection, and reduce the cleaning residue of an external medium oil phase.

In a third aspect, some embodiments of the present application provide a cosmetic comprising the oil core globules provided in any one of the preceding embodiments.

The features and capabilities of the present application are described in further detail below in connection with the examples:

the oil core coated gel beads of 1000+/-200 mu m are prepared by adopting a calcium alginate system and adopting a microfluidic technology mould shape and a dripping method.

(one) preparation of oil core gel beads

The oil core coagulated beads, the external phase raw materials include: deionized water, glycerol, butanediol, xanthan gum, gellan gum, sodium alginate, calcium ions, agar, PEG/PPG-14/7 dimethyl ether, and antiseptic. The internal phase raw materials comprise: caprylic/capric/succinic triglyceride, squalane, ubiquinone, tocopherol, and radix Arnebiae extract.

In each of the examples and comparative examples, the specific raw materials and contents of the oil core beads are shown in Table 1.

TABLE 1 raw material components and contents (w/w%) of examples and comparative examples

The preparation method comprises the following steps:

taking a microfluidic-model-based dripping method as an example, 1000+/-200 mu m oil core-coated gel beads are prepared in the example and the comparative example, and the method comprises the following steps:

(1) Configuring a first phase: mixing deionized water, glycerol, dipropylene glycol, xanthan gum, gellan gum, sodium alginate, phenoxyethanol, PEG/PPG-14/7 dimethyl ether and agar according to the proportion shown in Table 1, heating to above 90deg.C, maintaining the temperature for 20min, at 8000rpm, homogenizing for 2min;

(2) Configuring a second phase: mixing caprylic acid/capric acid/succinic acid triglyceride, triglyceride (ethyl caproate), squalane, ubiquinone, tocopherol, and radix Arnebiae extract according to the ratio of table 1, and stirring to uniformity;

(4) And (3) simultaneously draining the first phase prepared in the step (1) and the second phase prepared in the step (2) into the calcium chloride or calcium lactate solution of the third phase prepared in the step (3) by using a T-shaped pipe by means of pumping force to form oil core coated gel beads. The first phase and the third phase react to form an outer phase; the second phase is an internal phase, and is surrounded by an external phase.

(5) Filtering the oil core coagulated beads prepared in the step (4), and cleaning with deionized water.

(II) preparing essence matrix:

the composition and composition of the matrix are shown in Table 2.

TABLE 2 raw material composition of essence matrix and content (w/w%)

The specific preparation method of the essence matrix comprises the following steps:

heating the phase A to 85 ℃, preserving heat for 20min, and homogenizing at 7000rpm for 2min; stirring and cooling, and adding phase B into phase A; the temperature is reduced to below 40 ℃ and phase C is added; stirring uniformly and discharging.

And (III) preparing essence.

Soaking the oil core beads prepared in the first step and the comparative example in an external phase for more than 1 hour to fully react, filtering, cleaning by using deionized water, and adding the solution into the matrix prepared in the second step to prepare the oil-containing bead essence.

And (IV) testing the performance of the essence.

Experimental example 1 drip status, formability and stability test:

test sample: examples and comparative examples, and the essences thereof.

The testing method comprises the following steps:

1. drop state: visually observing sedimentation of oil core coagulated beads and oil floating condition thereof

2. Formability: visually observing whether the ball forming form of the oil core coagulated beads is complete

3. Stability test:

and (3) centrifuging, high-temperature, low-temperature and high-low-temperature alternation and normal-temperature treatment are carried out on each bead essence sample. The process parameters were as follows:

centrifugation (1500 rpm,10 min), high temperature (45 ℃,6 months), low temperature (-18 ℃,6 months), high-low temperature alternation (45 ℃ and-18 ℃ alternation, 6 months), normal temperature (25 ℃,6 months).

4. Skin feel evaluation: the oil core gel bead essence was applied to the arm and evaluated for residual feel and spreadability.

The results of each performance test are shown in Table 3.

TABLE 3 dripping State, formability and 6 month stability test results

As can be seen from table 3, all the examples of oil core beads added with 60-90% caprylic/capric/succinic triglyceride of the present application have excellent sedimentation properties, and do not generate the phenomena of floating of the beads and surface oil slivers, affecting the subsequent dripping. On the other hand, it was found from comparison of example 3 with comparative examples 1, 2 and 3 that the sedimentation properties of oil-containing globules were significantly affected when the content of other components in the first and third phases was kept constant while the amount of caprylic/capric/succinic triglyceride added in the second phase was decreased and the ratio of triglyceride to squalane was increased. From the above, it can be demonstrated that the oil core beads having 60 to 90% of caprylic/capric/succinic triglyceride added to the oil phase have excellent bulk stability.

Further, in comparative examples 1, 2 and 3, when the content of caprylic/capric/succinic triglyceride is less than 60%, the oil core coated beads floating on the surface of the soaking solution are stacked and collided, resulting in the influence of floating oil (refer to fig. 2); and when the oil slick is too much, the condensed beads which are dropped later cannot enter the soaking liquid for reaction due to the separation of the surface layer oil slick. In addition, as can be seen from Table 3, the lower the content of caprylic/capric/succinic triglyceride, the more pronounced the phenomenon of oil slick generation.

Further, as can be seen from table 3, examples 4, 5, 6 were inferior in skin feel. As is clear from Table 1, the higher the content of the solid agent such as gellan gum and agar, the higher the hardness of the resulting microbead, and the more serious the residual feeling. On the other hand, in examples 5 and 6, small bubbles appeared in the serum in the low-temperature and high-temperature alternating stability test. This phenomenon is considered to be a phenomenon in which bubbles are generated by low-temperature differentiated water when the added amount of gellan gum or agar is too high. Therefore, when there is a certain demand for skin feel and appearance, it is preferable that the gellan gum and agar content be less than 0.5%.

In summary, it is understood that example 3 is preferred in combination with the results of the centrifugal stability, the high-low temperature stability and the skin feel evaluation.

Experimental example 2

The appearance and microstructure of the oil core beads prepared in example 3 were examined. Wherein the microstructure of the oil core coagulated beads prepared in example 3 was observed by optical microscopy. The results are shown in figure 1, figure 3 and figure 4 of the specification.

FIG. 1 is an external view (side view) of the oil core beads prepared in example 3, which were settled and piled up at the bottom of a beaker, at a first view angle; fig. 2 is an external view (side view) of comparative example 1 at a first view angle, in which the oil core globules float above the reaction liquid and oil floating occurs on the surface layer of the liquid surface. Fig. 3 is an external view (top view) of the oil core beads prepared in example 3 from a second perspective. FIG. 4 is a microstructure of the oil core beads prepared in example 3.

As can be seen from fig. 1, fig. 3 and fig. 4, the inner phase of the oil core gel bead prepared in the embodiment of the application is an oil phase, the outer phase is a spherical calcium alginate capsule, and the oil core gel bead is coated with the oil core.

The foregoing description is only of the preferred embodiments of the present application and is not intended to limit the same, but rather, various modifications and variations may be made by those skilled in the art. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. An oil core bead comprising an outer phase and an inner phase; the outer phase comprises: calcium alginate; the internal phase comprises: oils and fats, and oil-soluble actives; the oil is caprylic acid/capric acid/succinic acid triglyceride, triglyceride and tri (ethylhexanoic acid) ester; the oil-soluble active substance is ubiquinone, tocopherol, and radix Arnebiae extract; the internal phase component comprises, by mass, 60-90% of the caprylic/capric/succinic triglyceride, 5-30% of the tri (ethylhexanoic) ester, 2.5-30% of the squalane, and the balance of the oil-soluble active substance.

2. The oil core gel bead of claim 1, wherein,

the oil-soluble actives include: at least one of ubiquinone, tocopherol, or an unstable oil soluble active.

3. The oil core gel bead of claim 2, wherein,

the unstable oil-soluble active substance is vegetable oil which is easy to be oxidatively decomposed; optionally, the labile oil-soluble active is selected from arnebia root extract, retinol and derivatives thereof.

4. The oil core gel bead according to any one of claim 1 to 3,

the outer phase further comprises: water, humectant, preservative, thickener and solid agent;

optionally, the humectant comprises polyols.

5. The oil core gel bead of claim 4, wherein,

the moisturizer comprises: at least one of glycerol, dipropylene glycol, PEG/PPG-14/7 dimethyl ether;

the preservative comprises phenoxyethanol;

optionally, the thickener and the solidifying agent comprise at least one of xanthan gum, gellan gum and agar.

6. The oil core gel bead of claim 1, wherein,

1, the external phase wall forming raw material comprises: sodium alginate and calcium ions; the mass ratio of the sodium alginate of the external phase to the calcium ions is (0.4-0.8): (0.2-0.5).

7. The oil core gel bead of claim 6, wherein,

the external phase comprises the following raw materials in percentage by mass: glycerin 1.0-10.0%, dipropylene glycol 1.0-10.0%, phenoxyethanol 0.1-1.0%, PEG/PPG-14/7 dimethyl ether 0.5-5.0%, xanthan gum 0-0.5%, gellan gum 0.1-1.0%, agar 0-1.0%, sodium alginate 0.4-0.8%, calcium ion 0.2-0.5%, and water in balance.

8. The oil core gel bead of claim 6, wherein,

the external phase comprises the following raw materials in percentage by mass: glycerin 1.0-10.0%, dipropylene glycol 1.0-10.0%, phenoxyethanol 0.1-1.0%, PEG/PPG-14/7 dimethyl ether 0.5-5.0%, xanthan gum 0-0.5%, gellan gum 0.2-1.0%, agar 0-1.0%, sodium alginate 0.4-0.8%, calcium ion 0.2-0.5%, and water in balance.

9. A method of preparing an oil core gel bead according to any one of claims 1 to 8, comprising:

uniformly mixing the caprylic acid/capric acid/succinic acid triglyceride, the triglyceride (ethylhexanoic acid), the squalane and the oil-soluble active substance to obtain an internal phase feed liquid;

the inner phase feed solution and the outer phase feed solution comprising alginate are simultaneously drained into a calcium salt solution.

10. A cosmetic comprising the oil core gel bead of any one of claims 1 to 9.