CN116440002A - Rhinitis spray preparation method based on traditional Chinese medicine composition - Google Patents
Rhinitis spray preparation method based on traditional Chinese medicine composition Download PDFInfo
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- CN116440002A CN116440002A CN202310717874.8A CN202310717874A CN116440002A CN 116440002 A CN116440002 A CN 116440002A CN 202310717874 A CN202310717874 A CN 202310717874A CN 116440002 A CN116440002 A CN 116440002A
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- 239000007921 spray Substances 0.000 title claims abstract description 130
- 239000003814 drug Substances 0.000 title claims abstract description 124
- 238000002360 preparation method Methods 0.000 title claims abstract description 70
- 206010039083 rhinitis Diseases 0.000 title claims abstract description 49
- 239000000203 mixture Substances 0.000 title claims abstract description 23
- 238000000034 method Methods 0.000 claims abstract description 127
- 239000007788 liquid Substances 0.000 claims abstract description 56
- 239000000843 powder Substances 0.000 claims abstract description 35
- 238000005507 spraying Methods 0.000 claims abstract description 26
- 238000001914 filtration Methods 0.000 claims abstract description 21
- 230000001954 sterilising effect Effects 0.000 claims abstract description 17
- 238000012360 testing method Methods 0.000 claims abstract description 16
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 11
- 238000005303 weighing Methods 0.000 claims abstract description 9
- 238000010438 heat treatment Methods 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims description 108
- 229940079593 drug Drugs 0.000 claims description 34
- 239000002904 solvent Substances 0.000 claims description 16
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- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 230000001105 regulatory effect Effects 0.000 claims description 5
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- 238000002156 mixing Methods 0.000 claims description 4
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- 244000197580 Poria cocos Species 0.000 claims description 3
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- 244000303379 Styrax officinalis Species 0.000 claims description 3
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- 230000001070 adhesive effect Effects 0.000 claims description 3
- 235000011399 aloe vera Nutrition 0.000 claims description 3
- 239000009670 cang er zi wan Substances 0.000 claims description 3
- 239000009136 dragon's blood Substances 0.000 claims description 3
- 235000019382 gum benzoic Nutrition 0.000 claims description 3
- 239000002994 raw material Substances 0.000 claims description 3
- 241000928504 Centipeda minima Species 0.000 claims description 2
- 244000143689 Crotalaria verrucosa Species 0.000 claims description 2
- 244000106592 Magnolia alba Species 0.000 claims description 2
- 235000017276 Salvia Nutrition 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 description 3
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- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
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Abstract
The invention relates to the technical field of rhinitis spray preparation, in particular to a rhinitis spray based on a traditional Chinese medicine composition and a preparation method thereof, wherein the method comprises the following steps: step S1, weighing the proportioning weights of different kinds of medicinal powder by using a weighing instrument; step S2, conveying the basic liquid medicine in the stirrer into a filter to filter out liquid medicine to be sterilized, heating and sterilizing the liquid medicine by using heat sterilization equipment to form a spray, and conveying the spray into a sprayer for spraying test when sterilization is completed; step S3, in the process of spraying the spray, the central control module adjusts the diameter of the filtering opening to a corresponding diameter according to the sliding area occupation ratio of the spray; the invention realizes the improvement of the preparation efficiency of the spray.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine spraying, in particular to a preparation method of rhinitis spray based on a traditional Chinese medicine composition.
Background
Rhinitis, i.e. inflammatory diseases of the nasal cavity, is an inflammation of the nasal mucosa caused by viruses, bacteria, allergens, various physicochemical factors and certain systemic diseases. The main pathological changes of rhinitis are congestion, swelling, exudation, hyperplasia, atrophy or necrosis of nasal mucosa, and the rhinitis spray is a commonly used medicament for treating rhinitis at present, can be directly sprayed to affected parts, has good treatment effect, but has the problem of reduced preparation efficiency caused by uneven and unstable medicament mixing in the preparation process.
Chinese patent publication No.: CN110876765a discloses a spray for treating rhinitis, which relates to the field of medical medicines, and is prepared from fructus Xanthii, flos Magnoliae, herba Centipedae, radix et rhizoma Rhei, lactobacillus and Mel by processing, and can be used by spraying nasal spray to nasal cavity. The spray for treating rhinitis is prepared from natural medicinal materials, is simple to use, has small side effect and good curative effect, and can be used for treating rhinitis, nasosinusitis, nasal polyp and allergic rhinitis, so that the spray for treating rhinitis has the following problems: the preparation efficiency is reduced due to uneven and unstable mixing of the medicines in the preparation process of the spray.
Disclosure of Invention
Therefore, the invention provides a rhinitis spray based on a traditional Chinese medicine composition and a preparation method thereof, which are used for overcoming the defect that the preparation efficiency is reduced due to uneven and unstable medicine mixing in the preparation process of the spray in the prior art.
In order to achieve the above purpose, the invention provides a preparation method of rhinitis spray based on a traditional Chinese medicine composition, which comprises the following steps:
step S1, weighing the proportion weight of different kinds of medicinal powder by using a weighing instrument, adding a basic solvent into a stirrer, and stirring the weighed medicinal powder with the basic solvent to form basic liquid medicine;
Step S2, conveying the basic liquid medicine in the stirrer into a filter to filter out liquid medicine to be sterilized, heating and sterilizing the liquid medicine by using heat sterilization equipment to form a spray, and conveying the spray into a sprayer for spraying test when sterilization is completed;
and S3, in the process of spraying the spray, the central control module adjusts the diameter of the filtering opening to a corresponding diameter according to the sliding area occupation ratio of the spray, adjusts the rotating speed of the stirring motor according to the variance of the adjacent spacing between the adhered medicines on the upper surface of the stirring container, and secondarily adjusts the rotating speed of the stirring motor to a second corresponding rotating speed according to the layering width of the liquid medicine surface in the stirring container.
Further, the central control module determines whether the uniformity of the spray is within an allowable range according to the sliding area ratio of the spray in the spray spraying test process, wherein,
the first uniformity judging method is that the central control module judges that the uniformity of the spray is in an allowable range according to a preset first sliding area occupation ratio condition;
the second type of uniformity judging method is that when the central control module judges that the uniformity of the spray is lower than an allowable range according to a preset second sliding area occupation ratio condition, the diameter of a filtering opening of the filter is adjusted to a corresponding diameter by calculating the difference value between the sliding area occupation ratio of the spray and the first preset sliding area occupation ratio;
The third type of uniformity judging method is that when the central control module judges that the uniformity of the spray is lower than the allowable range according to the preset third sliding area ratio condition, the central control module judges whether the uniformity of the stirring process is lower than the allowable range or not according to the variance of the adjacent intervals of the adhered medicines on the upper surface of the stirring container,
the first preset sliding area occupation ratio is that the sliding area occupation ratio of the spray is smaller than or equal to a first preset sliding area occupation ratio, the second preset sliding area occupation ratio is that the sliding area occupation ratio is larger than the first preset sliding area occupation ratio and smaller than or equal to a second preset sliding area occupation ratio, the third preset sliding area occupation ratio is that the sliding area occupation ratio is larger than the second preset sliding area occupation ratio, and the first preset sliding area occupation ratio is smaller than the second preset sliding area occupation ratio;
the calculation formula of the sliding area ratio of the spray is as follows:
wherein ,is the sliding area ratio of the spray agent, +.>The area of the spray on the spraying test board in the nth spraying process detected by the visual sensor is S, wherein S is the total area of the spraying test board, and n is a natural number greater than or equal to 1.
Further, the second type of uniformity determination method further includes three adjustment methods for the diameter of the filter opening of the filter, wherein,
According to the first diameter adjusting method, the central control module adjusts the diameter of the filtering port to a corresponding diameter according to a preset first sliding area occupation ratio difference value condition;
according to the second diameter adjusting method, the central control module adjusts the diameter of the filter opening to the first diameter by using a preset first diameter adjusting coefficient according to a preset second sliding area occupation ratio difference condition;
according to a third diameter adjusting method, the central control module adjusts the diameter of the filter opening to a second diameter by using a preset second diameter adjusting coefficient according to a preset third sliding area occupation ratio difference condition;
the preset first sliding area occupation ratio difference condition is that the difference between the sliding area occupation ratio and the second preset sliding area occupation ratio is smaller than or equal to the first preset sliding area occupation ratio difference; the preset second sliding area occupation ratio difference condition is that the difference between the sliding area occupation ratio and the second preset sliding area occupation ratio is larger than the first preset sliding area occupation ratio difference and smaller than or equal to the second preset sliding area occupation ratio difference, the preset third sliding area occupation ratio difference condition is that the difference between the sliding area occupation ratio and the second preset sliding area occupation ratio is larger than the second preset sliding area occupation ratio difference, the first preset sliding area occupation ratio difference is smaller than the first preset sliding area occupation ratio difference, and the preset first diameter adjustment coefficient is larger than the preset second diameter adjustment coefficient.
Further, the third type of uniformity determination method further includes two secondary determination methods, wherein,
the first secondary judging method is that the central control module judges that the uniformity of the stirring process is within an allowable range under the condition of a preset first variance;
the second secondary judgment method is that the central control module judges that the uniformity of the stirring process is lower than an allowable range under the condition of a preset second variance, and the rotating speed of the stirring motor is reduced to a first corresponding rotating speed by calculating the difference value between the variance of the adjacent spacing of the surface adhesive medicines and the preset variance;
the preset first variance condition is that the variance of the adjacent spacing between the surface-adhered medicines is smaller than the preset variance; the preset second variance condition is that the variance of the adjacent spacing of the surface-adhered medicines is larger than the preset variance.
Further, the second secondary judgment method also comprises two regulation methods for the rotation speed of the stirring motor, wherein,
the first type of rotation speed adjusting method is that the central control module adjusts the rotation speed of the stirring motor to a preset first rotation speed under the condition of a preset first difference value;
the second type of rotation speed adjusting method is that the central control module uses a first adjustment coefficient of the rotation speed of a preset motor to adjust the rotation speed of the stirring motor to a first rotation speed under the condition of a preset second variance difference value;
The preset first variance difference condition is that the difference between the variance of the adjacent spacing of the surface-adhered medicines and the preset variance is smaller than or equal to the preset variance difference, and the preset second variance difference condition is that the difference between the variance of the adjacent spacing of the surface-adhered medicines and the preset variance is larger than the preset variance difference.
Further, in the step S3, the central control module determines whether the stirring sufficiency is within the allowable range according to the layering width of the surface of the liquid medicine in the stirring container, wherein,
according to the first stirring judgment method, the central control module judges that stirring sufficiency is within an allowable range according to a preset first layering width condition;
in the second stirring judgment method, when the central control module judges that the stirring sufficiency is lower than the allowable range according to the preset second layering width condition, the stirring motor rotating speed is regulated to a second corresponding rotating speed by calculating the difference value between the layering width of the liquid medicine surface and the preset width,
the first preset layering width condition is that layering width of the liquid medicine surface is smaller than or equal to preset layering width, and the second preset layering width condition is that layering width of the liquid medicine surface is larger than preset layering width.
Further, the second stirring judgment method also comprises two secondary regulation methods aiming at the rotation speed of the stirring motor, wherein,
the first-class rotating speed secondary adjusting method is that the central control module adjusts the rotating speed of the stirring motor to a preset second rotating speed according to a preset first layering width difference value condition;
the second type of rotation speed secondary regulation method is that the central control module regulates the rotation speed of the stirring motor down to a second rotation speed by using a second regulation coefficient of the rotation speed of the preset motor under the condition of a preset second layering width difference value;
the difference value of the preset first layering width is that the difference value of the layering width of the liquid medicine surface and the first preset width is smaller than or equal to the preset width difference value; the preset second layering width difference condition is that the difference between the layering width of the liquid medicine surface and the first preset width is larger than the preset width difference.
Further, in the step S1, in the process of stirring the basic solvent and the medicine powder, the central control module determines whether the adhesion degree of the medicine powder in the process of adding the medicine powder into the stirrer is within an allowable range according to the actual air humidity at the opening of the stirrer detected by the air humidity sensor, wherein,
The first humidity judging method is that the central control module judges that the adhesion degree of the medicine powder is within an allowable range according to a preset first humidity condition;
the second humidity judging method is that when the central control module judges that the adhesion degree of the medicine powder is lower than the allowable range according to the preset second humidity condition, the opening width of the stirrer is adjusted to a corresponding value by calculating the difference value between the actual air humidity at the opening of the stirrer and the preset air humidity;
the first humidity condition is that the actual air humidity at the opening of the stirrer is smaller than or equal to the preset air humidity, and the second humidity condition is that the actual air humidity at the opening of the stirrer is larger than the preset air humidity.
Further, the second type of humidity determination method further includes two adjustment methods for the opening width of the stirrer, wherein,
according to a first type of opening adjustment method, the central control module adjusts the opening width of the stirrer to be smaller than a preset opening width according to a preset first air humidity difference value condition;
the second type of opening adjusting method is that the central control module adjusts the opening width of the stirrer to be smaller than the first opening width by using a preset opening adjusting coefficient under the condition of presetting a second air humidity difference value;
The difference value between the actual air humidity at the opening of the stirrer and the preset air humidity is smaller than or equal to the preset air humidity difference value according to the preset first air humidity difference value condition, and the difference value between the actual air humidity at the opening and the preset air humidity according to the preset second air humidity difference value condition is larger than the preset air humidity difference value.
The rhinitis spray prepared by the rhinitis spray preparation method based on the traditional Chinese medicine composition is characterized by comprising the following raw materials in parts by weight: honeysuckle, phellodendron, dandelion, aloe, fructus xanthii, campanumaea pilosula, crotalaria verrucosa, poria cocos, typha, magnolia alba, angelica dahurica, storax, angelica dahurica, centipeda minima, dragon's blood, prepared fleece-flower root, oyster, bai Mao, red-rooted salvia root and sansevieria trifasciata.
Compared with the prior art, the preparation method has the beneficial effects that the weight of the mixture ratio of different kinds of medicinal powder is weighed, and the weighed medicinal powder is stirred with the basic solvent to form basic liquid medicine; heating and sterilizing the basic liquid medicine to form a spray, and transporting the spray into a sprayer for spraying test when sterilization is completed; the central control module adjusts the diameter of the filtering opening to a corresponding diameter according to the sliding area ratio of the spray, adjusts the rotating speed of the stirring motor according to the variance of the adjacent spacing between the adhered medicines on the upper surface of the stirring container, and secondarily adjusts the rotating speed of the stirring motor to a second corresponding rotating speed according to the layering width of the liquid medicine surface in the stirring container.
Further, the rhinitis spray preparation method is provided with the preset first sliding area occupation condition, the preset second sliding area occupation condition and the preset third sliding area occupation condition, the sliding area occupation ratio is smaller than the first preset sliding area occupation ratio, the uniformity of the spray is lower than the allowable range, and the central control module judges whether the uniformity of the spray is in the allowable range or not, so that the spray preparation efficiency and the spray preparation accuracy are improved.
Further, the rhinitis spray preparation method is provided with a preset first sliding area occupation ratio difference condition, a preset second sliding area occupation ratio difference condition and a preset third sliding area occupation ratio difference condition, a preset first diameter adjustment coefficient and a preset second diameter adjustment coefficient, the central control module adjusts the diameter of the filtering opening by using the corresponding diameter adjustment coefficient according to the difference between the sliding area occupation ratio and the preset occupation ratio, and the diameter of particles in the liquid medicine is reduced by adjusting the diameter of the filtering opening, so that the spray preparation efficiency and the preparation accuracy are improved.
Further, the rhinitis spray preparation method is provided with the preset first variance condition and the preset second variance condition, the variance of the adjacent spacing between the surface adhesion medicines is larger than the preset variance, which indicates that the uniformity of the stirring process is lower than the allowable range, and the central control module judges whether the uniformity of the stirring process is within the allowable range or not, so that the spray preparation efficiency and the preparation accuracy are improved.
Furthermore, the rhinitis spray preparation method is provided with a preset first variance difference condition and a preset second variance difference condition, the central control module adjusts the rotation speed of the stirring motor according to the difference between the variances of the adjacent intervals of the surface-adhered medicines and the preset variances, and the medicine powder and the basic solvent are fused more uniformly by adjusting the rotation speed of the stirring motor, so that the spray preparation efficiency and the spray preparation accuracy are improved.
Furthermore, the rhinitis spray preparation method is provided with the preset first layering width condition and the preset second layering width condition, the layering width of the liquid medicine surface in the stirring container is larger than the preset first layering width, which indicates that the stirring sufficiency is lower than the allowable range, and the central control module judges the sufficiency of stirring, so that the spray preparation efficiency and the preparation accuracy are improved.
Furthermore, the rhinitis spray preparation method is provided with a preset first layering width difference condition and a preset second layering width difference condition, the central control module carries out secondary adjustment on the rotation speed of the stirring motor according to the difference between the layering width of the liquid medicine surface and the first preset width, and the medicine powder and the basic solvent are fused more fully by adjusting the rotation speed of the stirring motor, so that the spray preparation efficiency and the preparation accuracy are improved.
Further, the rhinitis spray preparation method is provided with the preset first humidity condition and the preset second humidity condition, the fact that the air humidity at the opening of the stirrer is larger than the preset air humidity indicates that the adhesion degree of the medicine powder is lower than the allowable range, and the central control module judges the air humidity at the opening of the stirrer, so that the spray preparation efficiency and the preparation accuracy are improved.
Furthermore, the rhinitis spray preparation method is provided with a preset first air humidity difference condition and a preset second air humidity difference condition, the central control module adjusts the opening width of the stirrer according to the difference value between the actual air humidity at the opening of the stirrer and the preset air humidity, and the adhesion of air moisture to essential medicine powder is reduced by adjusting the opening width of the stirrer, so that the spray preparation efficiency and the preparation accuracy are improved.
Drawings
FIG. 1 is a flowchart of a method for preparing a rhinitis spray based on a Chinese medicinal composition according to an embodiment of the present invention;
FIG. 2 is a block diagram of the overall structure of a filter involved in the preparation method of the rhinitis spray based on the traditional Chinese medicine composition in the embodiment of the invention;
fig. 3 is a specific flowchart of step S2 of the method for preparing a rhinitis spray based on a Chinese medicinal composition according to an embodiment of the present invention;
Fig. 4 is a specific flowchart of step S3 of the method for preparing a rhinitis spray based on a Chinese medicinal composition according to an embodiment of the present invention.
Detailed Description
In order that the objects and advantages of the invention will become more apparent, the invention will be further described with reference to the following examples; it should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
Preferred embodiments of the present invention will be described below with reference to the accompanying drawings. It should be understood by those skilled in the art that these embodiments are merely for explaining the technical principles of the present invention, and are not intended to limit the scope of the present invention.
It should be noted that, in the description of the present invention, terms such as "upper," "lower," "left," "right," "inner," "outer," and the like indicate directions or positional relationships based on the directions or positional relationships shown in the drawings, which are merely for convenience of description, and do not indicate or imply that the apparatus or elements must have a specific orientation, be constructed and operated in a specific orientation, and thus should not be construed as limiting the present invention.
Furthermore, it should be noted that, in the description of the present invention, unless explicitly specified and limited otherwise, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be either fixedly connected, detachably connected, or integrally connected, for example; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention can be understood by those skilled in the art according to the specific circumstances.
Please refer to fig. 1, 2, 3 and 4, which are respectively an overall flowchart of an embodiment of the present invention; the method relates to an overall structure block diagram of the filter; a specific flowchart of step S2 and a flowchart of step S3. The embodiment of the invention relates to a preparation method of a rhinitis spray based on a traditional Chinese medicine composition, which comprises the following steps: step S1, weighing the proportion weight of different kinds of medicinal powder by using a weighing instrument, adding a basic solvent into a stirrer, and stirring the weighed medicinal powder with the basic solvent to form basic liquid medicine;
step S2, conveying the basic liquid medicine in the stirrer into a filter to filter out liquid medicine to be sterilized, heating and sterilizing the liquid medicine by using heat sterilization equipment to form a spray, and conveying the spray into a sprayer for spraying test when sterilization is completed;
and S3, in the process of spraying the spray, the central control module adjusts the diameter of the filtering opening to a corresponding diameter according to the sliding area occupation ratio of the spray, adjusts the rotating speed of the stirring motor according to the variance of the adjacent spacing between the adhered medicines on the upper surface of the stirring container, and secondarily adjusts the rotating speed of the stirring motor to a second corresponding rotating speed according to the layering width of the liquid medicine surface in the stirring container.
Specifically, in the step S2, the process of preparing the base chemical solution into a spray includes:
step S21, the central control module filters the basic liquid medicine for a plurality of times according to the diameter of a preset filtering port to obtain the liquid medicine to be sterilized;
step S22, the central control module carries out heating sterilization on the liquid medicine to be sterilized according to the highest temperature that various medicine powders in the liquid medicine do not fail to obtain a spray;
in step S23, the central control module transports the spray to the sprayer, and prepares for a subsequent spraying test.
In the step S3, the process of performing the spraying test on the spray includes:
step S31, the central control module judges whether the sliding area occupation ratio of the spray agent is within an allowable range or not according to the sliding area occupation ratio of the spray agent, and adjusts the diameter of a filtering opening of the filter or carries out secondary judgment;
step S32, the central control module carries out secondary judgment on the uniformity of the stirring process according to the variance of the adjacent spacing between the surface-adhered medicines, and adjusts the rotating speed of the stirring motor;
and step S33, the central control module judges whether the stirring sufficiency is within an allowable range according to the layering width of the liquid surface of the stirring container, and secondarily adjusts the rotating speed of the stirring motor.
The preparation method of the invention comprises the steps of weighing the proportioning weights of different kinds of medicinal powder, and stirring the weighed medicinal powder with a basic solvent to form basic liquid medicine; heating and sterilizing the basic liquid medicine to form a spray, and transporting the spray into a sprayer for spraying test when sterilization is completed; the central control module adjusts the diameter of the filtering opening to a corresponding diameter according to the sliding area ratio of the spray, adjusts the rotating speed of the stirring motor according to the variance of the adjacent spacing between the adhered medicines on the upper surface of the stirring container, and secondarily adjusts the rotating speed of the stirring motor to a second corresponding rotating speed according to the layering width of the liquid medicine surface in the stirring container.
Referring to fig. 4, in step S3, the central control module determines whether the uniformity of the spray is within the allowable range according to the sliding area ratio of the spray during the spray spraying test, wherein,
the first uniformity judging method is that the central control module judges that the uniformity of the spray is in an allowable range according to a preset first sliding area occupation ratio condition;
the second type of uniformity judging method is that when the central control module judges that the uniformity of the spray is lower than an allowable range according to a preset second sliding area occupation ratio condition, the diameter of a filtering opening of the filter is adjusted to a corresponding diameter by calculating the difference value between the sliding area occupation ratio of the spray and the first preset sliding area occupation ratio;
The third type of uniformity judging method is that when the central control module judges that the uniformity of the spray is lower than the allowable range according to the preset third sliding area ratio condition, the central control module judges whether the uniformity of the stirring process is lower than the allowable range or not according to the variance of the adjacent intervals of the adhered medicines on the upper surface of the stirring container,
the first sliding area occupation ratio is smaller than or equal to a first preset sliding area occupation ratio of the spray, the second sliding area occupation ratio is larger than the first preset sliding area occupation ratio and smaller than or equal to a second preset sliding area occupation ratio, the third sliding area occupation ratio is larger than the second preset sliding area occupation ratio, and the first preset sliding area occupation ratio is smaller than the second preset sliding area occupation ratio.
Specifically, the preset slip area ratio isThe first preset sliding area ratio is +.>The second preset sliding area ratio is +.>，/>。
The rhinitis spray preparation method is provided with the preset first sliding area occupation condition, the preset second sliding area occupation condition and the preset third sliding area occupation condition, the sliding area occupation ratio is smaller than the first preset sliding area occupation ratio to indicate that the uniformity of the spray is lower than the allowable range, and the central control module judges whether the uniformity of the spray is in the allowable range or not, so that the spray preparation efficiency and the spray preparation accuracy are improved.
The calculation formula of the slip area ratio comprises the following steps:
wherein ,is the sliding area ratio->The area of the upper spraying agent sliding in the nth spraying process is S, the total area of the spraying test board is S, and n is a natural number greater than or equal to 1.
Continuing to participate in fig. 4, the second type of uniformity determination method further includes three adjustment methods for the diameter of the filter mouth of the filter, wherein,
according to the first diameter adjusting method, the central control module adjusts the diameter of the filtering port to a corresponding diameter according to a preset first sliding area occupation ratio difference value condition;
according to the second diameter adjusting method, the central control module adjusts the diameter of the filter opening to the first diameter by using a preset first diameter adjusting coefficient according to a preset second sliding area occupation ratio difference condition;
according to a third diameter adjusting method, the central control module adjusts the diameter of the filter opening to a second diameter by using a preset second diameter adjusting coefficient according to a preset third sliding area occupation ratio difference condition;
the preset first sliding area occupation ratio difference condition is that the difference between the sliding area occupation ratio and the second preset sliding area occupation ratio is smaller than or equal to the first preset sliding area occupation ratio difference; the preset second sliding area occupation ratio difference condition is that the difference between the sliding area occupation ratio and the second preset sliding area occupation ratio is larger than the first preset sliding area occupation ratio difference and smaller than or equal to the second preset sliding area occupation ratio difference, the preset third sliding area occupation ratio difference condition is that the difference between the sliding area occupation ratio and the second preset sliding area occupation ratio is larger than the second preset sliding area occupation ratio difference, the first preset sliding area occupation ratio difference is smaller than the first preset sliding area occupation ratio difference, and the preset first diameter adjustment coefficient is larger than the preset second diameter adjustment coefficient.
Specifically, the difference between the preset slip area ratio and the second preset slip area ratio isSetting-> The first preset sliding area is +.>The second preset sliding area is +.>Presetting the first diameter adjusting coefficient as +.>Presetting the second diameter adjusting coefficient as +.>，/> ，The method comprises the steps of carrying out a first treatment on the surface of the The corresponding diameter is preset as d0, and the diameter of the filter port after adjustment is +.> , wherein ,/>For presetting the i-th diameter adjustment coefficient, i=1, 2 is set.
The rhinitis spray preparation method is provided with a preset first sliding area occupation ratio difference condition, a preset second sliding area occupation ratio difference condition and a preset third sliding area occupation ratio difference condition, a preset first diameter adjustment coefficient and a preset second diameter adjustment coefficient, the central control module adjusts the diameter of a filtering port by using the corresponding diameter adjustment coefficient according to the difference between the sliding area occupation ratio and the preset occupation ratio, and the diameter of particles in liquid medicine is reduced by adjusting the diameter of the filtering port, so that the spray preparation efficiency and the preparation accuracy are improved.
With continued reference to fig. 4, the third type of uniformity determination method further includes two secondary determination methods, wherein,
the first secondary judging method is that the central control module judges that the uniformity of the stirring process is within an allowable range under the condition of a preset first variance;
The second secondary judgment method is that the central control module judges that the uniformity of the stirring process is lower than an allowable range under the condition of a preset second variance, and the rotating speed of the stirring motor is reduced to a first corresponding rotating speed by calculating the difference value between the variance of the adjacent spacing of the surface adhesive medicines and the preset variance;
the preset first variance condition is that the variance of the adjacent spacing between the surface-adhered medicines is smaller than the preset variance; the preset second variance condition is that the variance of the adjacent spacing of the surface-adhered medicines is larger than the preset variance;
specifically, the variance of the adjacent spacing of the preset surface-adherent drugs isThe first preset variance is +.>。
The rhinitis spray preparation method is provided with the preset first variance condition and the preset second variance condition, the variance of the adjacent spacing of the surface adhesion medicines is larger than the preset variance, which indicates that the uniformity of the stirring process is lower than the allowable range, and the central control module judges whether the uniformity of the stirring process is within the allowable range or not, so that the spray preparation efficiency and the preparation accuracy are improved.
With continued reference to fig. 4, the second secondary determining method further includes two methods for adjusting the rotation speed of the stirring motor, wherein,
the first type of rotation speed adjusting method is that the central control module adjusts the rotation speed of the stirring motor to a preset first rotation speed under the condition of a preset first difference value;
The second type of rotation speed adjusting method is that the central control module uses a first adjustment coefficient of the rotation speed of a preset motor to adjust the rotation speed of the stirring motor to a first rotation speed under the condition of a preset second variance difference value;
the difference value of the preset first variance difference condition is that the difference value of the variance of the adjacent spacing of the surface adhesion drugs and the preset variance is smaller than or equal to the preset variance difference value, and the difference value of the preset second variance difference condition is that the difference value of the variance of the adjacent spacing of the surface adhesion drugs and the preset variance is larger than the preset variance difference value;
specifically, the difference between the variance of the adjacent spacing of the preset surface-adhered drugs and the preset variance isSetting upThe first preset variance difference is +.>Presetting a first rotational speed as +.>The central control module is provided with a first regulating coefficient of preset rotating speed of +.>The calculation of the rotation speed of the stirring motor after adjustment is +.> 。
The rhinitis spray preparation method is provided with a preset first variance difference condition and a preset second variance difference condition, the central control module adjusts the rotation speed of the stirring motor according to the variance of the adjacent spacing of the surface-adhered medicine and the preset variance, and the medicine powder and the basic solvent are fused more uniformly by adjusting the rotation speed of the stirring motor, so that the spray preparation efficiency and the preparation accuracy are improved.
With continued reference to fig. 4, in step S3, the central control module determines whether the stirring sufficiency is within the allowable range according to the layering width of the surface of the liquid medicine in the stirring container, where,
according to the first stirring judgment method, the central control module judges that stirring sufficiency is within an allowable range according to a preset first layering width condition;
in the second stirring judgment method, when the central control module judges that the stirring sufficiency is lower than the allowable range according to the preset second layering width condition, the stirring motor rotating speed is regulated to a second corresponding rotating speed by calculating the difference value between the layering width of the liquid medicine surface and the preset width,
the first preset layering width condition is that layering width of the liquid medicine surface is smaller than or equal to preset layering width, and the second preset layering width condition is that layering width of the liquid medicine surface is larger than the preset layering width;
specifically, the layering width of the surface of the preset liquid medicine is L, and the first preset layering width is L1.
The rhinitis spray preparation method is provided with the preset first layering width condition and the preset second layering width condition, the layering width of the surface of the liquid medicine in the stirring container is larger than the preset first layering width, which indicates that the stirring sufficiency is lower than the allowable range, and the central control module judges the sufficiency of stirring, so that the spray preparation efficiency and the preparation accuracy are improved.
With continued reference to fig. 4, the second type of stirring determination method further includes two secondary adjustment methods for the rotation speed of the stirring motor, wherein,
the first-class rotating speed secondary adjusting method is that the central control module adjusts the rotating speed of the stirring motor to a preset second rotating speed according to a preset first layering width difference value condition;
the second type of rotation speed secondary regulation method is that the central control module regulates the rotation speed of the stirring motor down to a second rotation speed by using a second regulation coefficient of the rotation speed of the preset motor under the condition of a preset second layering width difference value;
the difference value of the preset first layering width is that the difference value of the layering width of the liquid medicine surface and the first preset width is smaller than or equal to the preset width difference value; the preset second layering width difference condition is that the difference between the layering width of the liquid medicine surface and the first preset width is larger than the preset width difference;
specifically, the difference between the layering width of the preset liquid medicine surface and the first preset width isSetting-> The first preset width difference is +.>The second rotation speed is preset to +.>The central control module is provided with a second regulating coefficient of preset rotating speed of +.>The calculation of the rotation speed of the stirring motor after adjustment is +.> 。
The rhinitis spray preparation method is provided with a preset first layering width difference condition and a preset second layering width difference condition, the central control module carries out secondary adjustment on the rotation speed of the stirring motor according to the difference between the layering width of the liquid medicine surface and the first preset width, and the medicine powder and the basic solvent are fused more fully by adjusting the rotation speed of the stirring motor, so that the spray preparation efficiency and the preparation accuracy are improved.
With continued reference to fig. 1, in the step S1, during the process of stirring the base solvent and the drug powder, the central control module determines, according to the actual air humidity at the opening of the stirrer detected by the air humidity sensor, whether the adhesion degree of the drug powder during the process of adding the drug powder into the stirrer is within an allowable range, wherein,
the first humidity judging method is that the central control module judges that the adhesion degree of the medicine powder is within an allowable range according to a preset first humidity condition;
the second humidity judging method is that when the central control module judges that the adhesion degree of the medicine powder is lower than the allowable range according to the preset second humidity condition, the opening width of the stirrer is adjusted to a corresponding value by calculating the difference value between the actual air humidity at the opening of the stirrer and the preset air humidity;
wherein the preset first humidity condition is that the actual air humidity at the opening of the stirrer is less than or equal to the preset air humidity, the preset second humidity condition is that the actual air humidity at the opening of the stirrer is greater than the preset air humidity,
specifically, the actual air humidity at the opening of the stirrer is preset to RH, and the preset air humidity is RH1.
The rhinitis spray preparation method is provided with the preset first humidity condition and the preset second humidity condition, the fact that the air humidity at the opening of the stirrer is larger than the preset air humidity indicates that the adhesion degree of the medicine powder is lower than the allowable range, and the central control module judges the air humidity at the opening of the stirrer, so that the spray preparation efficiency and the preparation accuracy are improved.
Continuing to participate in fig. 1, the second type of humidity determination method further includes two adjustment methods for the opening width of the blender, wherein,
according to a first type of opening adjustment method, the central control module adjusts the opening width of the stirrer to be smaller than a preset opening width according to a preset first air humidity difference value condition;
the second type of opening adjusting method is that the central control module adjusts the opening width of the stirrer to be smaller than the first opening width by using a preset opening adjusting coefficient under the condition of presetting a second air humidity difference value;
the difference value between the actual air humidity at the opening of the stirrer and the preset air humidity is smaller than or equal to the preset air humidity difference value according to the preset first air humidity difference value condition, and the difference value between the actual air humidity at the opening and the preset air humidity is larger than the preset air humidity difference value according to the preset second air humidity difference value condition;
Specifically, the difference between the actual air humidity at the opening of the preset mixer and the preset air humidity is，/> Presetting the air humidity difference value as +.>The preset opening width is recorded as R0, a preset opening adjusting coefficient is gamma, and the opening width of the stirrer after adjustment is +.>。
The rhinitis spray preparation method is provided with a preset first air humidity difference condition and a preset second air humidity difference condition, the central control module adjusts the opening width of the stirrer according to the difference between the actual air humidity at the opening of the stirrer and the preset air humidity, and the adhesion of air moisture to essential medicine powder is reduced by adjusting the opening width of the stirrer, so that the spray preparation efficiency and the preparation accuracy are improved.
Specifically, the traditional Chinese medicine drops prepared by the rhinitis spray preparation method based on the traditional Chinese medicine composition comprise the following raw materials in parts by weight (g): 50g of honeysuckle, 60 g of phellodendron, 100 g of dandelion, 50g of aloe, 40 g of cocklebur fruit, 80 g of campanumaea pilosula, 120 g of crotalaria verniciosa, 50g of poria cocos, 50g of typha, 50g of white magnolia, 80 g of angelica dahurica, 60 g of storax, 80 g of angelica dahurica, 120 g of centipeda, 80 g of dragon's blood, 60 g of prepared fleece-flower root, 90 g of oyster, bai Mao g of oyster, 50g of red sage root and 50g of sansevieria trifasciata.
Example 1
The first preset slip area of embodiment 1 of the present invention has a difference ofThe second preset sliding area is a difference valuePresetting the first diameter adjusting coefficient as +.>Presetting the second diameter adjusting coefficient as +.>, wherein ,/>，/>，，/>。
In this embodiment, the difference between the preset slip area ratio and the second preset slip area ratio is obtained as The central control module judges +.>Use +.>The diameter of the filtering opening is adjusted, and the preset corresponding diameter is thatThe diameter of the filter orifice after adjustment is +.> 。
In the embodiment 1, the diameter of the filtering port is adjusted by calculating the difference between the sliding area ratio and the preset ratio and using the corresponding diameter adjusting coefficient, and the diameter of particles in the liquid medicine is reduced by reducing the diameter of the filtering port, so that the medicine powder and the basic solvent are more uniformly mixed, and the preparation efficiency of the spray is improved.
Thus far, the technical solution of the present invention has been described in connection with the preferred embodiments shown in the drawings, but it is easily understood by those skilled in the art that the scope of protection of the present invention is not limited to these specific embodiments. Equivalent modifications and substitutions for related technical features may be made by those skilled in the art without departing from the principles of the present invention, and such modifications and substitutions will be within the scope of the present invention.
Claims (10)
1. A preparation method of a rhinitis spray based on a traditional Chinese medicine composition is characterized by comprising the following steps:
step S1, weighing the proportion weight of different kinds of medicinal powder by using a weighing instrument, adding a basic solvent into a stirrer, and stirring the weighed medicinal powder with the basic solvent to form basic liquid medicine;
step S2, conveying the basic liquid medicine in the stirrer into a filter to filter out liquid medicine to be sterilized, heating and sterilizing the liquid medicine by using heat sterilization equipment to form a spray, and conveying the spray into a sprayer for spraying test when sterilization is completed;
and S3, in the process of spraying the spray, the central control module adjusts the diameter of the filtering opening to a corresponding diameter according to the sliding area occupation ratio of the spray, adjusts the rotating speed of the stirring motor according to the variance of the adjacent spacing between the adhered medicines on the upper surface of the stirring container, and secondarily adjusts the rotating speed of the stirring motor to a second corresponding rotating speed according to the layering width of the liquid medicine surface in the stirring container.
2. The method for preparing a rhinitis spray based on a Chinese medicinal composition according to claim 1, wherein in the step S3, the central control module determines whether the uniformity of the spray is within an allowable range according to the sliding area ratio of the spray during the spray spraying test, wherein,
The first uniformity judging method is that the central control module judges that the uniformity of the spray is in an allowable range according to a preset first sliding area occupation ratio condition;
the second type of uniformity judging method is that when the central control module judges that the uniformity of the spray is lower than an allowable range according to a preset second sliding area occupation ratio condition, the diameter of a filtering opening of the filter is adjusted to a corresponding diameter by calculating the difference value between the sliding area occupation ratio of the spray and the first preset sliding area occupation ratio;
the third type of uniformity judging method is that when the central control module judges that the uniformity of the spray is lower than the allowable range according to the preset third sliding area ratio condition, the central control module judges whether the uniformity of the stirring process is lower than the allowable range or not according to the variance of the adjacent intervals of the adhered medicines on the upper surface of the stirring container,
the first preset sliding area occupation ratio is that the sliding area occupation ratio of the spray is smaller than or equal to a first preset sliding area occupation ratio, the second preset sliding area occupation ratio is that the sliding area occupation ratio is larger than the first preset sliding area occupation ratio and smaller than or equal to a second preset sliding area occupation ratio, the third preset sliding area occupation ratio is that the sliding area occupation ratio is larger than the second preset sliding area occupation ratio, and the first preset sliding area occupation ratio is smaller than the second preset sliding area occupation ratio;
The calculation formula of the sliding area ratio of the spray is as follows: wherein ,/>Is the sliding area ratio of the spray agent, +.>Is a vision sensorAnd the detected area of the spray sliding on the spraying test board in the nth spraying process is S, wherein S is the total area of the spraying test board, and n is a natural number greater than or equal to 1.
3. The method for preparing a rhinitis spray based on a Chinese medicinal composition according to claim 2, wherein the second uniformity determination method further comprises three adjustment methods for the diameter of the filter opening of the filter, wherein,
according to the first diameter adjusting method, the central control module adjusts the diameter of the filtering port to a corresponding diameter according to a preset first sliding area occupation ratio difference value condition;
according to the second diameter adjusting method, the central control module adjusts the diameter of the filter opening to the first diameter by using a preset first diameter adjusting coefficient according to a preset second sliding area occupation ratio difference condition;
according to a third diameter adjusting method, the central control module adjusts the diameter of the filter opening to a second diameter by using a preset second diameter adjusting coefficient according to a preset third sliding area occupation ratio difference condition;
the preset first sliding area occupation ratio difference condition is that the difference between the sliding area occupation ratio and the second preset sliding area occupation ratio is smaller than or equal to the first preset sliding area occupation ratio difference; the preset second sliding area occupation ratio difference condition is that the difference between the sliding area occupation ratio and the second preset sliding area occupation ratio is larger than the first preset sliding area occupation ratio difference and smaller than or equal to the second preset sliding area occupation ratio difference, the preset third sliding area occupation ratio difference condition is that the difference between the sliding area occupation ratio and the second preset sliding area occupation ratio is larger than the second preset sliding area occupation ratio difference, the first preset sliding area occupation ratio difference is smaller than the first preset sliding area occupation ratio difference, and the preset first diameter adjustment coefficient is larger than the preset second diameter adjustment coefficient.
4. The method for preparing a rhinitis spray based on a Chinese medicinal composition according to claim 3, wherein the third type of uniformity determination method further comprises two secondary determination methods, wherein,
the first secondary judging method is that the central control module judges that the uniformity of the stirring process is within an allowable range under the condition of a preset first variance;
the second secondary judgment method is that the central control module judges that the uniformity of the stirring process is lower than an allowable range under the condition of a preset second variance, and the rotating speed of the stirring motor is reduced to a first corresponding rotating speed by calculating the difference value between the variance of the adjacent spacing of the surface adhesive medicines and the preset variance;
the preset first variance condition is that the variance of the adjacent spacing between the surface-adhered medicines is smaller than the preset variance; the preset second variance condition is that the variance of the adjacent spacing of the surface-adhered medicines is larger than the preset variance.
5. The method for preparing a rhinitis spray based on a Chinese medicinal composition according to claim 4, wherein the second secondary determination method further comprises two adjustment methods for the rotation speed of the stirring motor,
the first type of rotation speed adjusting method is that the central control module adjusts the rotation speed of the stirring motor to a preset first rotation speed under the condition of a preset first difference value;
The second type of rotation speed adjusting method is that the central control module uses a first adjustment coefficient of the rotation speed of a preset motor to adjust the rotation speed of the stirring motor to a first rotation speed under the condition of a preset second variance difference value;
the preset first variance difference condition is that the difference between the variance of the adjacent spacing of the surface-adhered medicines and the preset variance is smaller than or equal to the preset variance difference, and the preset second variance difference condition is that the difference between the variance of the adjacent spacing of the surface-adhered medicines and the preset variance is larger than the preset variance difference.
6. The method according to claim 5, wherein in the step S3, the central control module determines whether the stirring sufficiency is within the allowable range according to the layering width of the surface of the medicinal liquid in the stirring container,
according to the first stirring judgment method, the central control module judges that stirring sufficiency is within an allowable range according to a preset first layering width condition;
in the second stirring judgment method, when the central control module judges that the stirring sufficiency is lower than the allowable range according to the preset second layering width condition, the stirring motor rotating speed is regulated to a second corresponding rotating speed by calculating the difference value between the layering width of the liquid medicine surface and the preset width,
The first preset layering width condition is that layering width of the liquid medicine surface is smaller than or equal to preset layering width, and the second preset layering width condition is that layering width of the liquid medicine surface is larger than preset layering width.
7. The method for preparing a rhinitis spray based on a Chinese medicinal composition according to claim 6, wherein the second type of stirring determination method further comprises two secondary adjustment methods for the rotation speed of the stirring motor,
the first-class rotating speed secondary adjusting method is that the central control module adjusts the rotating speed of the stirring motor to a preset second rotating speed according to a preset first layering width difference value condition;
the second type of rotation speed secondary regulation method is that the central control module regulates the rotation speed of the stirring motor down to a second rotation speed by using a second regulation coefficient of the rotation speed of the preset motor under the condition of a preset second layering width difference value;
the difference value of the preset first layering width is that the difference value of the layering width of the liquid medicine surface and the first preset width is smaller than or equal to the preset width difference value; the preset second layering width difference condition is that the difference between the layering width of the liquid medicine surface and the first preset width is larger than the preset width difference.
8. The method for preparing a rhinitis spray based on a pharmaceutical composition according to claim 7, wherein in the step S1, the central control module determines whether the adhesion degree of the pharmaceutical powder to the mixer is within an allowable range according to the actual air humidity at the mixer opening detected by the air humidity sensor during the mixing of the base solvent and the pharmaceutical powder, wherein,
The first humidity judging method is that the central control module judges that the adhesion degree of the medicine powder is within an allowable range according to a preset first humidity condition;
the second humidity judging method is that when the central control module judges that the adhesion degree of the medicine powder is lower than the allowable range according to the preset second humidity condition, the opening width of the stirrer is adjusted to a corresponding value by calculating the difference value between the actual air humidity at the opening of the stirrer and the preset air humidity;
the first humidity condition is that the actual air humidity at the opening of the stirrer is smaller than or equal to the preset air humidity, and the second humidity condition is that the actual air humidity at the opening of the stirrer is larger than the preset air humidity.
9. The method for preparing a rhinitis spray based on a Chinese medicinal composition according to claim 8, wherein the second type of humidity determination method further comprises two adjustment methods for the opening width of the agitator,
according to a first type of opening adjustment method, the central control module adjusts the opening width of the stirrer to be smaller than a preset opening width according to a preset first air humidity difference value condition;
the second type of opening adjusting method is that the central control module adjusts the opening width of the stirrer to be smaller than the first opening width by using a preset opening adjusting coefficient under the condition of presetting a second air humidity difference value;
The difference value between the actual air humidity at the opening of the stirrer and the preset air humidity is smaller than or equal to the preset air humidity difference value according to the preset first air humidity difference value condition, and the difference value between the actual air humidity at the opening and the preset air humidity according to the preset second air humidity difference value condition is larger than the preset air humidity difference value.
10. A rhinitis spray prepared by the method for preparing a rhinitis spray based on a Chinese medicinal composition according to any one of claims 1 to 9, which is characterized in that the raw material composition comprises: honeysuckle, phellodendron, dandelion, aloe, fructus xanthii, campanumaea pilosula, crotalaria verrucosa, poria cocos, typha, magnolia alba, angelica dahurica, storax, angelica dahurica, centipeda minima, dragon's blood, prepared fleece-flower root, oyster, bai Mao, red-rooted salvia root and sansevieria trifasciata.
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Citations (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19835823A1 (en) * | 1998-08-10 | 1999-10-07 | Lindopharm Gmbh | Antibiotic composition useful for preparing stable aqueous suspensions |
| DE19923628A1 (en) * | 1999-05-22 | 2000-11-23 | Herbert Huettlin | Manufacture of solid particulates containing chemically-, biologically- or pharmaceutically-active materials, employs rotary atomizer directing droplets into fluids causing them to set |
| US20040185111A1 (en) * | 2002-12-10 | 2004-09-23 | Rubino Orapin P. | Method of preparing biologically active formulations |
| CN1565695A (en) * | 2003-06-18 | 2005-01-19 | 杨佳荣 | Method for producing nanometer particles of plant, traditional Chinese medicine, chemical prescriptions, biological prescriptions |
| JP2005334122A (en) * | 2004-05-25 | 2005-12-08 | Shionogi & Co Ltd | Method for coating tablet |
| CN1879606A (en) * | 2006-05-02 | 2006-12-20 | 沈阳药科大学 | Preparation of novel drug delivery system based on liquid spray method |
| CN101287449A (en) * | 2002-04-11 | 2008-10-15 | 米迪缪尼疫苗股份有限公司 | Preservation of bioactive materials by spray drying |
| CN201772709U (en) * | 2010-07-22 | 2011-03-23 | 云南理想药业有限公司 | Novel device for producing, spraying and drying Xueniao'an capsules |
| CN104138452A (en) * | 2013-10-21 | 2014-11-12 | 河南润弘制药股份有限公司 | Preparation method of Chinese medicinal composition for deficiency of both qi and blood |
| CN104547763A (en) * | 2014-12-19 | 2015-04-29 | 王金奎 | Traditional Chinese medicine preparation for treating frequent blepharospasm, as well as preparation method |
| CN105055314A (en) * | 2015-09-28 | 2015-11-18 | 杭州安德科技有限公司 | Abiraterone oral spray and use and preparation methods thereof |
| CN106565386A (en) * | 2016-10-28 | 2017-04-19 | 重庆长安工业(集团)有限责任公司 | Method for conducting mixed preparation of tracer composition through boiling granulator |
| CN107441560A (en) * | 2016-05-30 | 2017-12-08 | 任汉学 | A kind of polysaccharide biology nasal nursing spray and preparation method thereof |
| CN109223626A (en) * | 2018-11-23 | 2019-01-18 | 黑龙江省科学院火山与矿泉研究所 | Wudalianchi cold spring mouth and nose nursing spray and preparation method thereof |
| CN109432817A (en) * | 2018-11-02 | 2019-03-08 | 江阴天江药业有限公司 | A kind of the automation extraction separation method and granule preparation method of the Chinese medicine of the effective component containing thermal sensitivity |
| EP3733165A1 (en) * | 2017-12-26 | 2020-11-04 | Limited Liability Company "Scientific-Industrial Innovation Deployment Center" | Method of generating medication in aerosol form |
| CN112022976A (en) * | 2020-10-14 | 2020-12-04 | 安徽保金药业有限公司 | Preparation process of rhinitis spray |
| CN113694024A (en) * | 2021-08-05 | 2021-11-26 | 广州零界医药有限公司 | Physiological seawater nasal cavity sprayer |
| CN214908607U (en) * | 2021-01-29 | 2021-11-30 | 云南艾柯生物科技有限公司 | Experiment intelligence image guide animal medicine drenches system of taking |
| CN115177674A (en) * | 2022-08-08 | 2022-10-14 | 张萌 | External spray for treating neck, shoulder, waist and leg pains and preparation method thereof |
| CN115350617A (en) * | 2022-08-22 | 2022-11-18 | 杭州师范大学钱江学院 | Liquid medicine test stirring device with self-cleaning function and stirring method thereof |
| CN116370411A (en) * | 2023-02-14 | 2023-07-04 | 赣江新区博安医药科技有限公司 | Fluticasone propionate nasal spray and production process thereof |
-
2023
- 2023-06-16 CN CN202310717874.8A patent/CN116440002B/en active Active
Patent Citations (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19835823A1 (en) * | 1998-08-10 | 1999-10-07 | Lindopharm Gmbh | Antibiotic composition useful for preparing stable aqueous suspensions |
| DE19923628A1 (en) * | 1999-05-22 | 2000-11-23 | Herbert Huettlin | Manufacture of solid particulates containing chemically-, biologically- or pharmaceutically-active materials, employs rotary atomizer directing droplets into fluids causing them to set |
| CN101287449A (en) * | 2002-04-11 | 2008-10-15 | 米迪缪尼疫苗股份有限公司 | Preservation of bioactive materials by spray drying |
| US20040185111A1 (en) * | 2002-12-10 | 2004-09-23 | Rubino Orapin P. | Method of preparing biologically active formulations |
| CN1565695A (en) * | 2003-06-18 | 2005-01-19 | 杨佳荣 | Method for producing nanometer particles of plant, traditional Chinese medicine, chemical prescriptions, biological prescriptions |
| JP2005334122A (en) * | 2004-05-25 | 2005-12-08 | Shionogi & Co Ltd | Method for coating tablet |
| CN1879606A (en) * | 2006-05-02 | 2006-12-20 | 沈阳药科大学 | Preparation of novel drug delivery system based on liquid spray method |
| CN201772709U (en) * | 2010-07-22 | 2011-03-23 | 云南理想药业有限公司 | Novel device for producing, spraying and drying Xueniao'an capsules |
| CN104138452A (en) * | 2013-10-21 | 2014-11-12 | 河南润弘制药股份有限公司 | Preparation method of Chinese medicinal composition for deficiency of both qi and blood |
| CN104547763A (en) * | 2014-12-19 | 2015-04-29 | 王金奎 | Traditional Chinese medicine preparation for treating frequent blepharospasm, as well as preparation method |
| CN105055314A (en) * | 2015-09-28 | 2015-11-18 | 杭州安德科技有限公司 | Abiraterone oral spray and use and preparation methods thereof |
| CN107441560A (en) * | 2016-05-30 | 2017-12-08 | 任汉学 | A kind of polysaccharide biology nasal nursing spray and preparation method thereof |
| CN106565386A (en) * | 2016-10-28 | 2017-04-19 | 重庆长安工业(集团)有限责任公司 | Method for conducting mixed preparation of tracer composition through boiling granulator |
| EP3733165A1 (en) * | 2017-12-26 | 2020-11-04 | Limited Liability Company "Scientific-Industrial Innovation Deployment Center" | Method of generating medication in aerosol form |
| CN109432817A (en) * | 2018-11-02 | 2019-03-08 | 江阴天江药业有限公司 | A kind of the automation extraction separation method and granule preparation method of the Chinese medicine of the effective component containing thermal sensitivity |
| CN109223626A (en) * | 2018-11-23 | 2019-01-18 | 黑龙江省科学院火山与矿泉研究所 | Wudalianchi cold spring mouth and nose nursing spray and preparation method thereof |
| CN112022976A (en) * | 2020-10-14 | 2020-12-04 | 安徽保金药业有限公司 | Preparation process of rhinitis spray |
| CN214908607U (en) * | 2021-01-29 | 2021-11-30 | 云南艾柯生物科技有限公司 | Experiment intelligence image guide animal medicine drenches system of taking |
| CN113694024A (en) * | 2021-08-05 | 2021-11-26 | 广州零界医药有限公司 | Physiological seawater nasal cavity sprayer |
| CN115177674A (en) * | 2022-08-08 | 2022-10-14 | 张萌 | External spray for treating neck, shoulder, waist and leg pains and preparation method thereof |
| CN115350617A (en) * | 2022-08-22 | 2022-11-18 | 杭州师范大学钱江学院 | Liquid medicine test stirring device with self-cleaning function and stirring method thereof |
| CN116370411A (en) * | 2023-02-14 | 2023-07-04 | 赣江新区博安医药科技有限公司 | Fluticasone propionate nasal spray and production process thereof |
Non-Patent Citations (5)
| Title |
|---|
| BRANDON J. THOMAS 等: "Analytical method development for characterizing ingredient-specific particle size distributions of nasal spray suspension products", JOURNAL OF PHARMACEUTICAL SCIENCES, no. 7, pages 2778 - 2788 * |
| TONG X 等: "Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity", COMPUTERS IN BIOLOGY & MEDICINE, pages 40 - 48 * |
| 尹超: "鹅不食草抗变应性鼻炎有效部位筛选及其鼻喷雾剂的制备工艺研究", 中国优秀硕士学位论文全文数据库 医药卫生科技辑, no. 09, pages 057 - 3 * |
| 崔素芬;廖芬;何全光;孙健;张娥珍;辛明;黄茂康;李丽;: "采用离心喷雾干燥技术制备桑葚果粉", 食品与发酵工业, no. 11, pages 73 - 78 * |
| 袁华: "丙酸氟替卡松鼻喷剂处方工艺研究", 中国优秀硕士学位论文全文数据库工程科技Ⅰ辑, no. 06, pages 016 - 420 * |
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