CN116439318A - Calcium supplementing nutrient solution for animals and preparation method thereof - Google Patents
Calcium supplementing nutrient solution for animals and preparation method thereof Download PDFInfo
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- CN116439318A CN116439318A CN202310315579.XA CN202310315579A CN116439318A CN 116439318 A CN116439318 A CN 116439318A CN 202310315579 A CN202310315579 A CN 202310315579A CN 116439318 A CN116439318 A CN 116439318A
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- calcium
- nutrient solution
- animals
- supplementing nutrient
- supplementing
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- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 239000011575 calcium Substances 0.000 title claims abstract description 63
- 229910052791 calcium Inorganic materials 0.000 title claims abstract description 63
- 235000015097 nutrients Nutrition 0.000 title claims abstract description 56
- 241001465754 Metazoa Species 0.000 title claims abstract description 46
- 230000001502 supplementing effect Effects 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title abstract description 7
- 229960005069 calcium Drugs 0.000 claims abstract description 62
- 239000004227 calcium gluconate Substances 0.000 claims abstract description 21
- 229960004494 calcium gluconate Drugs 0.000 claims abstract description 21
- 235000013927 calcium gluconate Nutrition 0.000 claims abstract description 21
- NEEHYRZPVYRGPP-UHFFFAOYSA-L calcium;2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Ca+2].OCC(O)C(O)C(O)C(O)C([O-])=O.OCC(O)C(O)C(O)C(O)C([O-])=O NEEHYRZPVYRGPP-UHFFFAOYSA-L 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 15
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000872 buffer Substances 0.000 claims abstract description 9
- 239000011574 phosphorus Substances 0.000 claims abstract description 9
- 229910052698 phosphorus Inorganic materials 0.000 claims abstract description 9
- 239000001527 calcium lactate Substances 0.000 claims abstract description 8
- 229960002401 calcium lactate Drugs 0.000 claims abstract description 8
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims abstract description 7
- 235000011086 calcium lactate Nutrition 0.000 claims abstract description 7
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims abstract description 6
- 229940124274 edetate disodium Drugs 0.000 claims abstract description 6
- 239000006172 buffering agent Substances 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 8
- 241000289690 Xenarthra Species 0.000 claims description 8
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical group [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 7
- 229940088594 vitamin Drugs 0.000 claims description 6
- 229930003231 vitamin Natural products 0.000 claims description 6
- 235000013343 vitamin Nutrition 0.000 claims description 6
- 239000011782 vitamin Substances 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 4
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 229930003316 Vitamin D Natural products 0.000 claims description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 238000007789 sealing Methods 0.000 claims description 4
- 235000019166 vitamin D Nutrition 0.000 claims description 4
- 239000011710 vitamin D Substances 0.000 claims description 4
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 4
- 229940046008 vitamin d Drugs 0.000 claims description 4
- 229910000402 monopotassium phosphate Chemical group 0.000 claims description 3
- 235000019796 monopotassium phosphate Nutrition 0.000 claims description 3
- 229930003270 Vitamin B Natural products 0.000 claims description 2
- 229930003427 Vitamin E Natural products 0.000 claims description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical group [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 claims description 2
- 235000019156 vitamin B Nutrition 0.000 claims description 2
- 239000011720 vitamin B Substances 0.000 claims description 2
- 235000019165 vitamin E Nutrition 0.000 claims description 2
- 229940046009 vitamin E Drugs 0.000 claims description 2
- 239000011709 vitamin E Substances 0.000 claims description 2
- -1 vitamin a Natural products 0.000 claims description 2
- 229940045997 vitamin a Drugs 0.000 claims description 2
- 239000000243 solution Substances 0.000 abstract description 49
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 abstract description 6
- 229910001424 calcium ion Inorganic materials 0.000 abstract description 6
- 238000003860 storage Methods 0.000 abstract description 5
- 239000008363 phosphate buffer Substances 0.000 abstract description 4
- 238000001556 precipitation Methods 0.000 abstract description 4
- 238000010521 absorption reaction Methods 0.000 abstract description 3
- CBMPTFJVXNIWHP-UHFFFAOYSA-L disodium;hydrogen phosphate;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound [Na+].[Na+].OP([O-])([O-])=O.OC(=O)CC(O)(C(O)=O)CC(O)=O CBMPTFJVXNIWHP-UHFFFAOYSA-L 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 3
- BUCIWTBCUUHRHZ-UHFFFAOYSA-K potassium;disodium;dihydrogen phosphate;hydrogen phosphate Chemical compound [Na+].[Na+].[K+].OP(O)([O-])=O.OP([O-])([O-])=O BUCIWTBCUUHRHZ-UHFFFAOYSA-K 0.000 abstract description 3
- 239000013589 supplement Substances 0.000 abstract description 3
- 239000013522 chelant Substances 0.000 abstract description 2
- 230000007774 longterm Effects 0.000 abstract description 2
- 239000002904 solvent Substances 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 abstract 1
- 238000004062 sedimentation Methods 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 10
- 229940069978 calcium supplement Drugs 0.000 description 9
- 206010006956 Calcium deficiency Diseases 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 210000000988 bone and bone Anatomy 0.000 description 2
- 230000014461 bone development Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 206010006895 Cachexia Diseases 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- 206010072610 Skeletal dysplasia Diseases 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- NEEHYRZPVYRGPP-IYEMJOQQSA-L calcium gluconate Chemical compound [Ca+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O NEEHYRZPVYRGPP-IYEMJOQQSA-L 0.000 description 1
- 230000009920 chelation Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 208000026500 emaciation Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000005802 health problem Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000011056 performance test Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- SDRZXZKXVBHREH-UHFFFAOYSA-M potassium;dihydrogen phosphate;phosphoric acid Chemical compound [K+].OP(O)(O)=O.OP(O)([O-])=O SDRZXZKXVBHREH-UHFFFAOYSA-M 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/26—Compounds containing phosphorus
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the field of additional food elements of animal feed, and particularly relates to a calcium supplementing nutrient solution for animals and a preparation method thereof. According to the invention, calcium gluconate with good biocompatibility is selected as a main calcium source, calcium lactate is added to promote dissolution, a disodium hydrogen phosphate-citric acid buffer pair or a disodium hydrogen phosphate-potassium dihydrogen phosphate buffer pair is added to regulate and maintain the pH of the system, and edetate disodium is added to chelate calcium in the calcium gluconate, so that the solubility of the calcium gluconate in a water solvent system is greatly improved, the calcium supplementing effect of the calcium supplementing nutrient solution is directly improved, sedimentation and precipitation of calcium ions after transportation and long-term storage are effectively prevented, and phosphorus element supplement is provided for animals while the pH of the calcium supplementing nutrient solution is maintained for a long time, and calcium absorption is promoted.
Description
Technical Field
The invention relates to the field of additional food elements of animal feed under IPC classification number A23K20/00, in particular to a calcium supplementing nutrient solution for animals and a preparation method thereof.
Background
Minerals are an important factor in animal nutrition, calcium is one of the most abundant mineral elements in animals, and essentially all life processes of the body require the participation of calcium. Mineral nutrition deficiency, particularly calcium deficiency, is a widely occurring animal problem in intensive feeding modes. Calcium deficiency can cause many health problems such as skeletal dysplasia, tooth dysplasia, emaciation, inappetence, dull hair and sparseness, etc., and can also lead to reduced productivity in animals such as poultry and cows.
The most effective measure for solving the calcium deficiency is calcium supplement. The reasonable diet, more foods with high calcium content are ingested, and the method is one of important ways of supplementing calcium; in addition, the selection of proper calcium supplementing nutrient solution is also an effective method for preventing and treating calcium deficiency. Especially for large animals such as cattle and horses, the most suitable way of calcium supplement is by drenching with liquid calcium supplement. Therefore, a good and efficient calcium supplement nutrient solution is important for animal calcium supplement.
The calcium supplementing nutrient solutions for animals sold in the market at present are various in variety and uneven in quality. An idealized calcium supplement formulation is ionized calcium. However, most ionized calcium is unstable or has a relatively large irritation to the animal's digestive tract. The organic compound of calcium has the advantages of high absorptivity and small irritation, but common organic matters of calcium such as calcium gluconate have low solubility in water and are easy to be settled in the processes of storage, transportation and the like. Patent CN201910890425.7 discloses a calcium supplementing nutrient solution for animals, wherein the mass fraction of the calcium source in the formula can only reach about 5%, and a large amount of organic solvent is needed to be added. Therefore, there is an urgent need for an efficient and stable calcium-supplementing nutrient solution for animals.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the calcium supplementing nutrient solution for animals, which has high efficiency, safety, high absorptivity, small irritation and stable system and has high calcium ion concentration.
On the other hand, the invention also aims at providing a preparation method of the calcium supplementing nutrient solution for animals.
In order to achieve the aim of the invention, the invention adopts the following technical scheme:
the calcium supplementing nutrient solution for animals is characterized by comprising the following components: a calcium source, disodium edentate, a buffer, vitamins, water; the buffer is composed of a component A and a component B.
Preferably, the calcium supplementing nutrient solution for animals comprises, by weight, 50-60 parts of a calcium source, 1-5 parts of edetate disodium, 10-30 parts of a buffering agent and 0.01-1 part of vitamins.
Preferably, the calcium source comprises calcium gluconate and calcium lactate.
Further preferably, the mass ratio of the calcium gluconate to the calcium lactate in the calcium source is 50:1-2.
Preferably, the concentration of the calcium gluconate in the calcium supplementing nutrient solution for animals is 90-100 g/L.
Preferably, the pH value of the calcium supplementing nutrient solution for animals is 3-6 or 8-10.
Further preferably, the pH of the calcium-supplementing nutrient solution for animals is 4 or 8.
Calcium gluconate has good biocompatibility, but has poor water solubility at normal temperature. According to the invention, calcium lactate is added as a cosolvent, so that the solubility of calcium gluconate in water is obviously improved, and the calcium gluconate is nearly saturated and dissolved in a system. However, near-saturated dissolved calcium gluconate is not stable in aqueous solvent systems and tends to settle out of solution after transport or storage for extended periods of time, producing macroscopic precipitation. The inventors have found that calcium gluconate settles more easily in neutral systems and is more stable in acidic or basic systems, especially those having a pH of 3 to 6 or 8 to 10. The invention creatively adds the buffering agent into the calcium supplementing nutrient solution, adjusts the pH value of the nutrient solution during production, and can ensure that the pH value of the calcium supplementing nutrient solution is kept at the pH environment of 3-6 or 8-10 for a long time without being influenced by the environment or the temperature, thereby ensuring that the calcium gluconate is not easy to separate out. On the other hand, the edetate disodium is added, and can generate chelation with free calcium ions in the solution to form additional intermolecular acting force, so that the calcium ions are fixed in the system and are not easy to separate out, and the stability of the calcium gluconate in the solution is further improved.
Preferably, component a of the buffer is disodium hydrogen phosphate and component B is citric acid or potassium dihydrogen phosphate.
Preferably, the mass ratio of the calcium and the phosphorus element of the disodium hydrogen phosphate in the calcium supplementing nutrient solution for animals is 1.5-2.5: 1.
further preferably, the mass ratio of the calcium and the phosphorus element of the disodium hydrogen phosphate in the calcium supplementing nutrient solution for animals is 2:1.
the invention specifically selects the disodium hydrogen phosphate-citric acid buffer pair and the disodium hydrogen phosphate-potassium dihydrogen phosphate buffer pair, which not only have the function of adjusting and maintaining the pH value of the solution, but also can be used as a phosphorus supplement, thereby being beneficial to promoting the absorption of calcium; in particular, the specific ratio of calcium to phosphorus in the invention is close to the ratio of calcium to phosphorus in animal bones, which is of great benefit to animal bone development and the like.
Preferably, the vitamin is selected from one or more of vitamin D, vitamin a, vitamin E, vitamin B.
Preferably, the components of the calcium-supplementing nutrient solution for animals further comprise glucose.
The invention also provides a preparation method of the calcium supplementing nutrient solution for animals, which comprises the following steps:
s1: adding a calcium source, disodium edentate and a component A of a buffering agent into water according to parts by weight, sealing, heating and stirring to completely dissolve the components;
s2: adding other components except a calcium source, disodium edentate and a buffering agent into the solution obtained in the step S1, and adding the component B of the buffering agent while stirring to adjust the pH; cooling to room temperature, adding water to a specified volume, and mixing uniformly.
Preferably, the heating temperature in S1 is 80 to 100 ℃.
Compared with the prior art, the invention has the following beneficial effects:
1. the calcium gluconate-calcium lactate composite calcium source with excellent biocompatibility is adopted, the defect of poor solubility of calcium gluconate in a water solvent is overcome, the content of calcium in the calcium supplementing nutrient solution is remarkably improved, and the calcium supplementing effect of the calcium supplementing nutrient solution is directly improved.
2. The pH value of the calcium-supplementing nutrient solution is creatively regulated and maintained by adding the buffering agent, the problem that calcium gluconate is easy to settle in a neutral environment is solved, the influence degree of environmental factors such as temperature, transportation and the like on the calcium-supplementing nutrient solution is reduced, and the calcium-supplementing nutrient solution can maintain long-term stability.
3. The disodium hydrogen phosphate-citric acid buffer pair and the disodium hydrogen phosphate-potassium dihydrogen phosphate buffer pair are specifically selected, so that the pH value of the solution can be regulated and maintained, and the phosphate-potassium dihydrogen phosphate buffer pair can be used as a phosphorus supplement, thereby being beneficial to promoting the absorption of calcium.
4. The ratio of the adopted calcium to the phosphorus is close to that of the animal bone, so that comprehensive and proper minerals are provided for the animal, and great benefits are provided for the bone development of the animal and the like.
5. The disodium edentate is added to chelate the free calcium ions in the calcium supplementing nutrient solution, so that the calcium ions are fixed in the system and are not easy to separate out, and the stability of the calcium gluconate in the calcium supplementing nutrient solution is further improved.
Drawings
FIG. 1 is a photograph showing the appearance of calcium supplement nutrient solutions of example 1 (right) and comparative example 1 (left) immediately after the preparation;
fig. 2 is a photograph showing the appearance of the calcium supplement nutrient solutions of example 1 (right) and comparative example 1 (left) when stored for 8 months.
Detailed Description
The present invention will be described in further detail with reference to the following specific examples, to which the present invention is not limited.
Example 1
The embodiment provides a calcium supplementing nutrient solution, which is prepared by the following components and methods:
s1: adding 50g of calcium gluconate, 1.20g of edetate disodium, 1.75g of calcium lactate and 11g of disodium hydrogen phosphate into 450mL of water, sealing and heating to 80 ℃, and stirring until the materials are completely dissolved;
s2: adding 25g of glucose and 37.5mg of water-soluble vitamin D into the solution obtained in the step S1, and adding a saturated citric acid aqueous solution while stirring to adjust the pH to pH=4; cooling to 25deg.C, adding water to volume of 500mL, and stirring.
Example 2
The embodiment provides a calcium supplementing nutrient solution, which is prepared by the following components and methods:
s1: adding 50g of calcium gluconate, 1.20g of edetate disodium, 1.75g of calcium lactate and 11g of disodium hydrogen phosphate into 450mL of water, sealing and heating to 100 ℃, and stirring until the materials are completely dissolved;
s2: adding 25g of glucose and 37.5mg of water-soluble vitamin D into the solution obtained in the step S1, and adding monopotassium phosphate while stirring to adjust the pH to pH=8; cooling to 25deg.C, adding water to volume of 500mL, and stirring.
Comparative example 1
The comparative example provides a calcium-supplementing nutrient solution, which is prepared from the following components in part by the same method as in example 1: disodium edentate was not added.
Comparative example 2
The comparative example provides a calcium-supplementing nutrient solution, which is prepared from the following components in part by the same method as in example 1: no disodium hydrogen phosphate was added.
Performance testing
1. Centrifugal stability test: 3mL of the calcium supplement nutrient solution of examples 1-2 and comparative examples 1-2 are respectively added into a 5mL centrifuge tube, centrifuged for 10min at a rotation speed of 5000r/min, and taken out to observe whether precipitation appears at the bottom.
2. Storage stability test: 1L each of the calcium-supplementing nutrient solutions prepared by the components and methods of examples 1-2 and comparative examples 1-2 was sealed in a transparent plastic bottle, and left in a warehouse for 24 months, and the appearance state of the nutrient solution was observed every month.
The results of the performance test are shown in Table 1.
| Centrifugal stability | Storage stability | |
| Example 1 | Clear transparent precipitate-free | Clear transparent without precipitate (as shown in figure 2) |
| Example 2 | Clear transparent precipitate-free | Clear transparent precipitate-free |
| Comparative example 1 | Clear transparent precipitate-free | The solution was cloudy at 8 months (as shown in FIG. 2) |
| Comparative example 2 | Clear transparent precipitate-free | After 6 months, solid precipitation appears at the bottom of the bottle |
Claims (10)
1. The calcium supplementing nutrient solution for animals is characterized by comprising the following components: a calcium source, disodium edentate, a buffer, vitamins, water; the buffer is composed of a component A and a component B.
2. The calcium-supplementing nutrient solution for animals according to claim 1, wherein the nutrient solution comprises, by weight, 50-60 parts of a calcium source, 1-5 parts of edetate disodium, 10-30 parts of a buffering agent and 0.01-1 part of vitamins.
3. The calcium-supplementing nutrient solution for animals according to claim 1 or 2, wherein the pH value of the calcium-supplementing nutrient solution for animals is 3 to 6 or 8 to 10.
4. The calcium-supplementing nutrient solution for animals according to claim 1 or 2, wherein the calcium source comprises calcium gluconate and calcium lactate.
5. The calcium-supplementing nutrient solution for animals according to claim 4, wherein the concentration of calcium gluconate in the calcium-supplementing nutrient solution for animals is 90-100 g/L.
6. The calcium-supplementing nutrient solution for animals according to claim 1 or 2, wherein the component a of the buffer is disodium hydrogen phosphate and the component B is citric acid or potassium dihydrogen phosphate.
7. The calcium-supplementing nutrient solution for animals according to claim 6, wherein the mass ratio of the calcium and the phosphorus element of disodium hydrogen phosphate in the calcium-supplementing nutrient solution for animals is 1.5-2.5: 1.
8. the calcium-supplementing nutrient solution for animals according to claim 1 or 2, wherein the vitamins are one or more selected from the group consisting of vitamin D, vitamin a, vitamin E and vitamin B.
9. The calcium-supplementing nutrient solution for animals according to claim 1 or 2, wherein the components of the calcium-supplementing nutrient solution for animals further comprise glucose.
10. The method for preparing a calcium-supplementing nutrient solution for animals according to any one of claims 1 to 9, comprising the steps of:
s1: adding a calcium source, disodium edentate and a component A of a buffering agent into water according to parts by weight, sealing, heating and stirring to completely dissolve the components;
s2: adding other components except a calcium source, disodium edentate and a buffering agent into the solution obtained in the step S1, and adding the component B of the buffering agent while stirring to adjust the pH; cooling to room temperature, adding water to a specified volume, and mixing uniformly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310315579.XA CN116439318A (en) | 2023-03-28 | 2023-03-28 | Calcium supplementing nutrient solution for animals and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202310315579.XA CN116439318A (en) | 2023-03-28 | 2023-03-28 | Calcium supplementing nutrient solution for animals and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN116439318A true CN116439318A (en) | 2023-07-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202310315579.XA Pending CN116439318A (en) | 2023-03-28 | 2023-03-28 | Calcium supplementing nutrient solution for animals and preparation method thereof |
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| Country | Link |
|---|---|
| CN (1) | CN116439318A (en) |
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2023
- 2023-03-28 CN CN202310315579.XA patent/CN116439318A/en active Pending
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