CN113678947A - Self-assembled small peptide chelated manganese feed additive and preparation method thereof - Google Patents
Self-assembled small peptide chelated manganese feed additive and preparation method thereof Download PDFInfo
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- CN113678947A CN113678947A CN202111009884.3A CN202111009884A CN113678947A CN 113678947 A CN113678947 A CN 113678947A CN 202111009884 A CN202111009884 A CN 202111009884A CN 113678947 A CN113678947 A CN 113678947A
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- small peptide
- manganese
- feed additive
- amino acid
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- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 title claims abstract description 66
- 229910052748 manganese Inorganic materials 0.000 title claims abstract description 65
- 239000011572 manganese Substances 0.000 title claims abstract description 65
- 239000003674 animal food additive Substances 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 39
- 150000001413 amino acids Chemical class 0.000 claims abstract description 31
- 239000002253 acid Substances 0.000 claims abstract description 23
- 239000011347 resin Substances 0.000 claims abstract description 22
- 229920005989 resin Polymers 0.000 claims abstract description 22
- 239000000843 powder Substances 0.000 claims abstract description 20
- 239000013522 chelant Substances 0.000 claims abstract description 18
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims abstract description 13
- 239000011656 manganese carbonate Substances 0.000 claims abstract description 12
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- XMWCXZJXESXBBY-UHFFFAOYSA-L manganese(ii) carbonate Chemical compound [Mn+2].[O-]C([O-])=O XMWCXZJXESXBBY-UHFFFAOYSA-L 0.000 claims abstract description 12
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- 238000000034 method Methods 0.000 claims description 4
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 3
- FDKWRPBBCBCIGA-REOHCLBHSA-N (2r)-2-azaniumyl-3-$l^{1}-selanylpropanoate Chemical compound [Se]C[C@H](N)C(O)=O FDKWRPBBCBCIGA-REOHCLBHSA-N 0.000 claims description 3
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- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 3
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 3
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- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 3
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 3
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 3
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 3
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 3
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- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 3
- 239000004472 Lysine Substances 0.000 claims description 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 3
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- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 3
- 239000004473 Threonine Substances 0.000 claims description 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 3
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 3
- 229960003767 alanine Drugs 0.000 claims description 3
- 235000004279 alanine Nutrition 0.000 claims description 3
- 229960003121 arginine Drugs 0.000 claims description 3
- 235000009697 arginine Nutrition 0.000 claims description 3
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- 229960001230 asparagine Drugs 0.000 claims description 3
- 235000009582 asparagine Nutrition 0.000 claims description 3
- 229960005261 aspartic acid Drugs 0.000 claims description 3
- 235000003704 aspartic acid Nutrition 0.000 claims description 3
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 3
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- 235000013922 glutamic acid Nutrition 0.000 claims description 3
- 239000004220 glutamic acid Substances 0.000 claims description 3
- 235000004554 glutamine Nutrition 0.000 claims description 3
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- 229960002885 histidine Drugs 0.000 claims description 3
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- 229960000310 isoleucine Drugs 0.000 claims description 3
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- 229960003136 leucine Drugs 0.000 claims description 3
- 235000018977 lysine Nutrition 0.000 claims description 3
- 229930182817 methionine Natural products 0.000 claims description 3
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- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 3
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- ZKZBPNGNEQAJSX-UHFFFAOYSA-N selenocysteine Natural products [SeH]CC(N)C(O)=O ZKZBPNGNEQAJSX-UHFFFAOYSA-N 0.000 claims description 3
- 229960001153 serine Drugs 0.000 claims description 3
- 235000004400 serine Nutrition 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
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- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 3
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- 238000001338 self-assembly Methods 0.000 claims 3
- 229960002989 glutamic acid Drugs 0.000 claims 1
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- 229960003646 lysine Drugs 0.000 claims 1
- 229960004452 methionine Drugs 0.000 claims 1
- 229960004799 tryptophan Drugs 0.000 claims 1
- ISPYRSDWRDQNSW-UHFFFAOYSA-L manganese(II) sulfate monohydrate Chemical compound O.[Mn+2].[O-]S([O-])(=O)=O ISPYRSDWRDQNSW-UHFFFAOYSA-L 0.000 abstract description 8
- 238000004090 dissolution Methods 0.000 abstract description 4
- 230000006651 lactation Effects 0.000 abstract description 4
- 241001465754 Metazoa Species 0.000 description 9
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- 239000000126 substance Substances 0.000 description 6
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
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- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- -1 amino acid salt Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
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- 210000000988 bone and bone Anatomy 0.000 description 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
- 229940062672 calcium dihydrogen phosphate Drugs 0.000 description 1
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- 150000001720 carbohydrates Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 229940038879 chelated zinc Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940046374 chromium picolinate Drugs 0.000 description 1
- GJYSUGXFENSLOO-UHFFFAOYSA-N chromium;pyridine-2-carboxylic acid Chemical compound [Cr].OC(=O)C1=CC=CC=N1.OC(=O)C1=CC=CC=N1.OC(=O)C1=CC=CC=N1 GJYSUGXFENSLOO-UHFFFAOYSA-N 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
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- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
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- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
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- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- SURQXAFEQWPFPV-UHFFFAOYSA-L iron(2+) sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Fe+2].[O-]S([O-])(=O)=O SURQXAFEQWPFPV-UHFFFAOYSA-L 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
Abstract
The invention relates to the technical field of small peptide chelated manganese, in particular to an autonomously assembled small peptide chelated manganese feed additive and a preparation method thereof, wherein the feed additive comprises the following components: the small peptide chelate manganese-containing composite material comprises amino acid, strong acid resin, inorganic manganese and methanol, wherein small peptide powder is prepared by utilizing the amino acid and the strong acid resin, small peptide dissolution is obtained after the small peptide powder is dissolved, manganese carbonate is added into the small peptide dissolution to form a chelate, and the small peptide chelate manganese is obtained after the methanol is separated out. According to the invention, the small peptide chelated manganese is added into the feed, so that the preparation flow and the preparation time are both reduced, the quality of piglets is improved, and the problems that manganese sulfate monohydrate is mostly added as a feed additive in the preparation process of the existing feed additive, although manganese is also one, the birth weight of piglets, the head number, the litter weight, the average weight and the lactation amount of 14-day piglets are all lower are effectively solved.
Description
Technical Field
The invention relates to the technical field of small peptide chelated manganese, in particular to an autonomously assembled small peptide chelated manganese feed additive and a preparation method thereof.
Background
The feed additive is a small amount or trace substance added in the processes of feed production, processing and use, the dosage of the feed additive is small but the effect is obvious, the feed additive is a raw material inevitably used in modern feed industry, and has obvious effects on enhancing the nutritive value of basic feed, improving the animal production performance, ensuring the animal health, saving the feed cost, improving the quality of livestock products and the like, manganese is mainly added into the feed of livestock and poultry, the most commonly used manganese is inorganic manganese, generally, the manganese is very low in the retention amount in the body of the livestock and poultry, the livestock can obtain enough manganese from vegetable feed, the manganese requirement of the poultry is higher than that of mammals, and generally, the poultry feed does not contain enough manganese (200mg/kg dry feed), such as corn, wheat, pea, soybean and the like, so that a proper amount of manganese is added into the daily ration of the poultry;
manganese is a less toxic one, has an important nutritional role in the animal body, is a structural component, an activating factor or an auxiliary factor of a plurality of enzymes, plays an important role in the growth and development of animal bones and the metabolism of fat and carbohydrate, and has certain influence on the reproduction of animals, and the manganese is absorbed and then transported to each organ in the animal body;
in the preparation process of the existing feed additive, manganese sulfate monohydrate is mostly added as a feed additive, although manganese is also one kind of the feed additive, the birth average weight of piglets, the head number, the litter weight, the average weight and the milk secretion of the piglets are all low, the reproduction rate and the quality of the piglets are reduced, and the piglets are not easy to absorb manganese elements, so that the capacity of the piglets is reduced, and the problem is solved.
Disclosure of Invention
The invention aims to provide an autonomously assembled small peptide chelated manganese feed additive and a preparation method thereof, and aims to solve the problems that manganese sulfate monohydrate is mostly added as a feed additive in the preparation process of the existing feed additive in the background technology, and the average birth weight, the head number, the litter weight, the average weight and the lactation yield of piglets in 14 days are low, and the absorption of manganese elements by the piglets is not easy, so that the productivity of the piglets is reduced.
In order to achieve the purpose, the invention provides the following technical scheme: an autonomously assembled small peptide chelated manganese feed additive comprises the following components: the small peptide chelate manganese-containing composite material comprises amino acid, strong acid resin, inorganic manganese and methanol, wherein small peptide powder is prepared by utilizing the amino acid and the strong acid resin, small peptide dissolution is obtained after the small peptide powder is dissolved, manganese carbonate is added into the small peptide dissolution to form a chelate, and the small peptide chelate manganese is obtained after the methanol is separated out.
Further, the amino acids are 21 kinds of common amino acids such as glycine, alanine, valine, leucine, isoleucine, methionine, proline, tryptophan, serine, tyrosine, cysteine, phenylalanine, asparagine, glutamine, threonine, aspartic acid, glutamic acid, lysine, arginine, histidine, selenocysteine and the like.
Furthermore, the amino acid proportion is evenly distributed according to the required components, and the total concentration is 200 g/L.
Further, the mass of the strong acid resin is 5% of the weight of the amino acid.
Further, the inorganic manganese is 10-15% manganese carbonate solid.
A preparation method of an autonomously assembled small peptide chelated manganese feed additive comprises the following steps:
the method comprises the following steps: preparing water, amino acid and resin strong acid;
firstly, dissolving amino acid in water, and adding strong acid resin;
step two: heating and stirring;
heating and stirring the solution obtained in the step one to enable the solution to react;
step three: filtering;
filtering strong acid resin after the solution in the step two is reacted;
step four: drying;
drying the solution obtained in the third step to obtain small peptide powder;
step five: dissolving;
dissolving the small peptide powder dried in the fourth step to obtain a small peptide solution;
step six: heating and stirring are carried out again;
heating and stirring the small peptide solution obtained in the fifth step, and adding inorganic manganese under the heating and stirring conditions to enable the small peptide to react with the manganese to form a chelate;
step seven: concentrating and separating out;
and (4) concentrating the solution obtained in the sixth step, adding methanol to separate out small peptide chelated manganese, and filtering and drying to obtain the small peptide chelated manganese.
Further, the preparation condition of the small peptide powder is that the small peptide powder reacts for 3 hours at 80 ℃.
Further, the mass ratio of the small peptide to the manganese carbonate is 3-5:1, and the reaction condition is that the reaction lasts for 2 hours at 80 ℃.
Compared with the prior art, the invention has the beneficial effects that:
1. the small peptide chelated manganese is added into the feed, the small peptide chelated trace elements are compounds with a cyclic structure generated by the coordination reaction of trace element metal ions necessary for the growth of animals and small peptides or short peptide substances, and have important effects on improving the production performance, the anti-stress capability and the like of livestock and poultry, and the manganese is easier to be absorbed by piglets through the coordination of the small peptide chelated manganese and the manganese, and meanwhile, under the action of the manganese, the important nutrient substances in the manganese are taken up by the piglets, so that the birth average weight of the piglets is increased, the head number, the litter weight and the average weight of the piglets are increased within 14 days, and the milk secretion is also improved;
2. secondly, the small peptide chelated manganese is added into the feed to replace the manganese sulfate monohydrate, so that the preparation cost is reduced both in the preparation process and the preparation time, the piglet quality is improved, the preparation cost is reduced under the action of the small peptide chelated manganese, and the problem that the productivity of the piglets is reduced because the manganese sulfate monohydrate is mostly added as the feed additive in the existing feed additive preparation process is effectively solved, and the problems that the average birth weight of the piglets, the head number, the litter weight, the average weight and the lactation amount of the piglets in 14 days are low and the absorption of the manganese element by the piglets is not easy are solved.
3. Compared with the original small peptide preparation technology such as fermentation and condensing agent, the strong acid resin has the advantages of easy separation and purification, easy regeneration and utilization and less three wastes.
4. The small peptide chelate salt has good absorption for inorganic salt and amino acid salt, is not easy to cause the saturation of an absorption channel, does not compete in the absorption between the small peptide chelate salt, is suitable for being mixed with the amino acid chelate salt for use, achieves the secondary supplement effect and improves the feed utilization rate.
Detailed Description
The technical solutions in the embodiments of the present invention are clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The embodiment provided by the invention comprises the following steps:
an autonomously assembled small peptide chelated manganese feed additive comprises the following components: amino acid, strong acid resin, inorganic manganese and methanol, wherein the small peptide powder is prepared by utilizing the amino acid and the strong acid resin, the small peptide powder is dissolved to obtain small peptide, manganese carbonate is added into the small peptide solution to form a chelate, the methanol is added into the chelate, the small peptide chelated manganese is obtained after the methanol is separated out, the small peptide chelated trace elements are compounds with cyclic structures generated by the coordination reaction of trace element metal ions necessary for the growth of animals and small peptide or short peptide substances, and the small peptide chelated manganese has important effects on improving the production performance, the anti-stress capability and the like of livestock and poultry.
The amino acids are 21 kinds of common amino acids such as glycine, alanine, valine, leucine, isoleucine, methionine, proline, tryptophan, serine, tyrosine, cysteine, phenylalanine, asparagine, glutamine, threonine, aspartic acid, glutamic acid, lysine, arginine, histidine, selenocysteine and the like.
The proportion of amino acid is evenly distributed according to the required components, the total concentration is 200g/L, the amino acid is an organic compound containing basic amino and acidic carboxyl, and the hydrogen atom on the carbon atom of the carboxylic acid is replaced by amino to form the compound.
The mass of the strong acid resin is 5% of the weight of the amino acid, and the strong acid resin is utilized, so that better regeneration efficiency and higher running exchange rate are brought.
The inorganic manganese is 10-15% manganese carbonate solid, the manganese carbonate is an inorganic compound, and carbonate of bivalent manganese is soluble in dilute acid, insoluble in water and ethanol, and can be used as fertilizer and feed additive.
A preparation method of an autonomously assembled small peptide chelated manganese feed additive comprises the following steps:
the method comprises the following steps: preparing water, amino acid and resin strong acid;
firstly, dissolving amino acid in water, and adding strong acid resin;
step two: heating and stirring;
heating and stirring the solution obtained in the step one to enable the solution to react;
step three: filtering;
filtering strong acid resin after the solution in the step two is reacted;
step four: drying;
drying the solution obtained in the third step to obtain small peptide powder;
step five: dissolving;
dissolving the small peptide powder dried in the fourth step to obtain a small peptide solution;
step six: heating and stirring are carried out again;
heating and stirring the small peptide solution obtained in the fifth step, and adding inorganic manganese under the heating and stirring conditions to enable the small peptide to react with the manganese to form a chelate;
step seven: concentrating and separating out;
and (3) concentrating the solution obtained in the step six, adding methanol to precipitate small peptide chelated manganese, filtering and drying to obtain the small peptide chelated manganese, wherein the small peptide chelated manganese is close to the trace element existing form of natural form in the animal body, has good chemical stability, higher biological value, easy digestion and absorption, interference resistance, no stimulation and no toxicity, and has a certain function of sterilizing and improving the immunity of the organism.
Through the cooperation of the small peptide chelated manganese, the manganese is easier to be absorbed by piglets, and meanwhile, under the action of the manganese, the important nutrients in the manganese are taken up by the piglets, so that the birth average weight of the piglets is increased, the number of the piglets in 14 days is increased, the litter weight and the average weight are increased, the milk secretion is improved, the preparation flow and the preparation time are reduced, the quality of the piglets is improved, and the preparation cost is reduced under the action of the small peptide chelated manganese.
The preparation condition of the small peptide powder is that the reaction is carried out for 3 hours at 80 ℃, the peptide is a biochemical substance between amino acid and protein, is smaller than protein molecules, is larger than the amino acid molecules, is a segment of the protein, and is called small molecular peptide or small peptide consisting of 2 to 4 amino acids.
The mass ratio of the small peptide to the manganese carbonate is 3-5:1, the reaction is carried out for 2h at the temperature of 80 ℃, and the small peptide and the manganese carbonate are fused under the matching action, so that the small peptide is easier to absorb.
The test effect is as follows:
1. the basic diet is prepared according to NRC (2012) pig nutrition requirements in the pig feeding Standard (NY/T65-2004) of China, the basic diet adopts a corn-soybean meal type, and a control group adopts inorganic trace elements (manganese sulfate monohydrate) as a nutrition supplement;
the experimental group added small peptide chelated manganese to replace equivalent manganese sulfate monohydrate, and the basic feed composition and various nutritional indexes are shown in the following table:
the premix is provided for each kilogram of feed: 140mg of manganese sulfate monohydrate/small chelated manganese, 20mg of copper sulfate pentahydrate, 124mg of ferrous sulfate heptahydrate, 10mg of magnesium sulfate, 0.2mg of potassium iodide, 133mg of zinc sulfate monohydrate, VA 5600IU, VD 3180 IU, VB 19mg, 17mg of citric acid, 3mg of antioxidant, 5mg of chromium picolinate, 250mg of calcium dihydrogen phosphate, 300mg of mountain flour and zeolite powder as a carrier.
The nutrient levels are calculated values.
2. A single-factor test is adopted, wherein 30 healthy sows with similar fat bodies and times of birth for 100 +/-3 days of gestation are selected and randomly divided into 2 groups, each group is 15 in number, 1 piglet is fed with the 2 kinds of feed respectively, and the test period is from 100 days of gestation to 14 days after farrowing. The grouping of the experimental piglets is as follows:
| group of | Additive for different copper sources in daily ration |
| Control group | Small peptide powder and zinc sulfate monohydrate |
| Test group | Small peptide chelated zinc |
3. Measurement indexes are as follows: average birth weight, head number of 14-day piglets, litter weight, average weight and lactation yield.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Claims (8)
1. The self-assembled small peptide chelated manganese feed additive is characterized by comprising the following components: the small peptide chelate manganese-containing composite material comprises amino acid, strong acid resin, inorganic manganese and methanol, wherein the amino acid and the strong acid resin are prepared to obtain small peptide powder, the small peptide powder is dissolved to obtain small peptide solution, manganese carbonate is added into the small peptide solution to form a chelate, the methanol is added into the chelate, and the small peptide chelate manganese is obtained after the methanol is separated out.
2. The self-assembled small peptide chelated manganese feed additive as claimed in claim 1, wherein said amino acids are 21 amino acids selected from the group consisting of glycine, alanine, valine, leucine, isoleucine, methionine, proline, tryptophan, serine, tyrosine, cysteine, phenylalanine, asparagine, glutamine, threonine, aspartic acid, glutamic acid, lysine, arginine, histidine and selenocysteine.
3. The self-assembly small peptide chelated manganese feed additive as claimed in claim 1, wherein the amino acid ratio is evenly distributed according to the required components, and the total concentration is 200 g/L.
4. The self-assembled small peptide chelated manganese feed additive as claimed in claim 1, wherein the mass of said strong acid resin is 5% of amino acid weight.
5. The self-assembling small peptide chelated manganese feed additive according to claim 1, wherein the inorganic manganese is 10-15% manganese carbonate solids.
6. A preparation method of an autonomously assembled small peptide chelated manganese feed additive is characterized by comprising the following steps:
the method comprises the following steps: preparing water, amino acid and resin strong acid;
firstly, dissolving amino acid in water, and adding strong acid resin;
step two: heating and stirring;
heating and stirring the solution obtained in the step one to enable the solution to react;
step three: filtering;
filtering strong acid resin after the solution in the step two is reacted;
step four: drying;
drying the solution obtained in the third step to obtain small peptide powder;
step five: dissolving;
dissolving the small peptide powder dried in the fourth step to obtain a small peptide solution;
step six: heating and stirring are carried out again;
heating and stirring the small peptide solution obtained in the fifth step, and adding inorganic manganese under the heating and stirring conditions to enable the small peptide to react with the manganese to form a chelate;
step seven: concentrating and separating out;
and (4) concentrating the solution obtained in the sixth step, adding methanol to separate out small peptide chelated manganese, and filtering and drying to obtain the small peptide chelated manganese.
7. The preparation method of the self-assembly small peptide chelated manganese feed additive, according to claim 6, is characterized in that the small peptide powder is prepared under the reaction condition of 80 ℃ for 3 hours.
8. The preparation method of the self-assembly small peptide chelated manganese feed additive, according to claim 6, is characterized in that the mass ratio of the small peptide to manganese carbonate is 3-5:1, and the reaction condition is that the reaction lasts for 2 hours at 80 ℃.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422426A (en) * | 1991-06-18 | 1995-06-06 | Eli Lilly And Company | Rapid synthesis and screening of peptide mimetics |
| CN102827907A (en) * | 2012-08-02 | 2012-12-19 | 广州市博善生物饲料有限公司 | Preparation method and application of small peptide chelated manganese compound |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5422426A (en) * | 1991-06-18 | 1995-06-06 | Eli Lilly And Company | Rapid synthesis and screening of peptide mimetics |
| CN102827907A (en) * | 2012-08-02 | 2012-12-19 | 广州市博善生物饲料有限公司 | Preparation method and application of small peptide chelated manganese compound |
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