CN116400076B - Sampling, reaction and detection integrated device - Google Patents
Sampling, reaction and detection integrated device Download PDFInfo
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- CN116400076B CN116400076B CN202310217883.0A CN202310217883A CN116400076B CN 116400076 B CN116400076 B CN 116400076B CN 202310217883 A CN202310217883 A CN 202310217883A CN 116400076 B CN116400076 B CN 116400076B
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- inner box
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- 238000001514 detection method Methods 0.000 title claims abstract description 102
- 238000005070 sampling Methods 0.000 title claims abstract description 19
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 15
- 238000007789 sealing Methods 0.000 claims abstract description 81
- 238000010828 elution Methods 0.000 claims abstract description 43
- 239000007788 liquid Substances 0.000 claims abstract description 42
- 238000007493 shaping process Methods 0.000 claims abstract description 22
- 238000000926 separation method Methods 0.000 claims description 17
- 239000000645 desinfectant Substances 0.000 claims description 8
- 230000000149 penetrating effect Effects 0.000 claims description 7
- 239000012780 transparent material Substances 0.000 claims description 3
- 239000003480 eluent Substances 0.000 abstract description 22
- 238000005192 partition Methods 0.000 abstract description 11
- 238000000034 method Methods 0.000 abstract description 10
- 230000000694 effects Effects 0.000 abstract description 9
- 239000003153 chemical reaction reagent Substances 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 11
- 230000001954 sterilising effect Effects 0.000 description 4
- 241000700605 Viruses Species 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 210000003928 nasal cavity Anatomy 0.000 description 2
- 206010011409 Cross infection Diseases 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
- A61L2202/10—Apparatus features
- A61L2202/15—Biocide distribution means, e.g. nozzles, pumps, manifolds, fans, baffles, sprayers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The application relates to the field of reagent detection, especially, relate to a sampling, reaction, detect integrated device, including casing and detection box, be equipped with in the casing with the casing internal partition for detecting the district and eluting the district's overhead gage, the detection box is located the detection district, the detection box is including the interior box that can be in the detection district internal activity, be located interior box and keep away from the transparent cover plate of elution district one side and be located the detection card between transparent cover plate and the interior box, interior box inside shaping has the cavity, the inside bottom has the detection connecting hole that communicates with the cavity towards one side shaping of detection card, interior box orientation one side shaping that is linked together with the cavity has the feed liquor hole that is linked together, the shaping has the play liquid hole on the overhead gage, and inlay on the side of last division face inwards box and be equipped with the sealing ring that laminates with interior box, the sealing ring is including the play liquid hole, interior box's active site is including making feed liquor hole and play liquid hole just to the position. The eluent is not required to be transferred between different devices in the whole process, so that the operation process is simplified.
Description
Technical Field
The application relates to the field of reagent detection, in particular to a sampling, reacting and detecting integrated device.
Background
At present, in order to avoid contacting dense population and reduce secondary cross infection, some high-risk areas can choose to detect virus antigens at home by adopting a virus kit self-detection mode. The existing self-checking mode is to automatically insert the swab into the nasal cavity for rotary sampling, then insert the sampled swab into the accommodating box of the sample eluent, soak the swab head in the sample extracting solution for a period of time, then drop the eluent in the accommodating box on the detecting card, and judge whether the sample is negative or positive after waiting for a period of time.
Aiming at the related technology, the applicant believes that the existing virus kit has the technical problem of complicated use process.
Disclosure of Invention
In order to simplify self-checking operation, the application provides a sampling, reaction and detection integrated device.
The application provides a sampling, reaction, detection integrated device adopts following technical scheme:
the utility model provides a sampling, reaction, detection integrated device, includes casing and detection box, be equipped with in the casing and divide into the upper division board of detection district and elution district with casing internal partition, the detection box is located the detection district, and the detection box is including the interior box that can be in the detection district internal activity, be located the interior box and keep away from the transparent cover plate of elution district one side and be located the detection card between transparent cover plate and the interior box, interior box internal shaping has the cavity, the bottom of inside has the detection connecting hole that communicates with the cavity towards one side shaping of detection card, interior box has the feed liquor hole that is linked together with the cavity towards one side shaping of elution district, the last shaping has the play liquid hole on the upper division board, and inlays in the one side of last division board towards interior box and be equipped with the sealing ring of laminating of interior box, and the sealing ring is including making the position that the feed liquor hole just right with the play liquid hole.
Through adopting above-mentioned technical scheme, with the inside detection zone and the elution district that divide into of casing, the swab that samples is put into the elution district in, after a period, with interior box activity to the position that feed liquor hole and play liquid hole are just right for the eluent gets into the cavity and drips on the detection card through detecting the connecting hole, both can judge after waiting a period and be negative or positive. The eluent is not required to be transferred between different devices in the whole process, so that the operation process is simplified.
Preferably, the shell is provided with an indication hole, the length direction of the indication hole is the same as the moving direction of the inner box, a groove is formed in the side wall of one side of the inner box, which is far away from the elution area, the transparent cover plate is embedded in the groove, an operation block penetrating out of the indication hole is formed on the transparent cover plate, and when the operation block is abutted to one side of the indication hole, the liquid inlet hole is opposite to the liquid outlet hole.
By adopting the technical scheme, the transparent cover plate is embedded in the groove, and the operation block arranged on the transparent cover plate is used for conveniently operating the detection box to move. The indication hole plays a role in displaying the detection result on one hand, and on the other hand, the movable position of the detection box can be controlled, so that the detection box can be conveniently and accurately operated to move to the position where the liquid inlet hole and the liquid outlet hole are aligned. Meanwhile, the position of the operation block abutting against the other side of the indication hole can be used as the position state during detection, and a CT line can be set to assist interpretation by taking the position state as a reference.
Preferably, the upper separation plate separates the shell along the vertical direction, the position shaping that is close to the bottom in the shell has the bottom separation board to separate the space of shell bottom into the antiseptic solution and hold the chamber, the part shaping that the bottom separation board is located the detection zone below has circular shape to be weak mouthful, interior box is along the upper and lower direction activity, and the bottom surface of interior box just has the awl point to the position shaping of weak mouthful, and the cover is equipped with the sealing washer with shell inner wall butt on the lateral wall that the interior box is close to shaping awl point one end.
Through adopting above-mentioned technical scheme, separate the disinfectant accommodation chamber that forms through the bottom division board in the bottom of casing. When disinfection is to be performed after detection is finished, the weak opening can be punctured by the conical tip, so that disinfection liquid flows into the elution area to be mixed with the elution liquid for disinfection. No additional disinfection articles are needed, and the use is more convenient.
Preferably, a limiting column is formed at the position, which is not aligned with the weak opening, of the bottom surface of the inner box, and the length of the limiting column is shorter than that of the cone tip.
Through adopting above-mentioned technical scheme, set up spacing post in the bottom surface of box so that interior box can not hug closely on the bottom division board and lead to the eluent unable elution district that flows into.
Preferably, the shell is communicated with the upper end of one side of the detection area, the width of the groove is equal to that of the transparent cover plate, the height of the groove is larger than that of the transparent cover plate, a distance is reserved between the upper end of the transparent cover plate and the upper side wall of the groove, the upper side and the lower side of the transparent cover plate are provided with stop blocks for limiting the detection card in the upper and lower directions in a extending mode, the left side and the right side of the detection card are provided with stop blocks in the extending mode in the groove, the extending distance of the stop blocks is larger than that of the stop blocks, the bottom surface of the groove is provided with limit grooves matched with the stop blocks in a mode close to the two side positions, the width of the limit grooves is larger than that of the stop blocks, the positions, located above the stop blocks, of the two side walls of the limit grooves are provided with pressing sheets which incline upwards from the two sides.
Through adopting above-mentioned technical scheme, when the disinfection step, can press the top of detecting the box with force, stopper extrusion preforming is to both sides deformation this moment for interior box downward movement and puncture the weak mouth through the awl point. When the inner box moves downwards and the operation block is abutted with the lower side face of the indication hole, the positions of the transparent cover plate and the detection card cannot be changed, so that the result of the indication Kong Douqu can be still obtained at the moment, and the situation that the user needs to re-detect after the user finishes operating the detection card without keeping the detection result record is avoided.
Preferably, the upper end of the detection box exceeds the detection area, and the upper port of the shell on one side of the detection area is inclined downwards away from one side of the elution area.
Through adopting above-mentioned technical scheme, set up the upper end of detecting the box and surpass the detection zone, and this side slope of casing for when holding the device, can conveniently apply effort through thumb press detecting the box.
Preferably, the part of the shell corresponding to the elution area is made of transparent material.
Through adopting above-mentioned technical scheme, set up the window in the position of elution district and make the user can observe the state of elution district, when the eluent got into the cavity, can judge the liquid volume that gets into in the cavity through observing the bubble to avoid excessive elution liquid drop to the detection card.
Preferably, a sealing cover is arranged at a position of the shell above the elution zone, a perforation is formed on the sealing cover, and a penetrating sealing piece is arranged in the perforation.
Through adopting above-mentioned technical scheme, set up the wearing formula sealing member on the sealing cap and make the swab can stretch into in the elution district, avoid the eluent to flow out.
Preferably, the middle part shaping of the wearable sealing member has last sealing washer and hugs closely the lower sealing washer of last sealing washer lower surface, goes up sealing washer and lower sealing washer and all is circularly, and the last shaping of lower sealing washer has lower Y word incision, and the center of lower Y word incision is close to one side of sealing washer down, goes up the last shaping of sealing washer and has last Y word incision, and the center of going up Y word incision is close to one side that the last sealing washer kept away from lower Y word incision center.
Through adopting above-mentioned technical scheme, the incision that forms on the sealing washer itself has better sealed effect, and the last Y of going up the sealing washer is the dislocation with the lower Y of sealing washer, therefore even the incision department cooperation is inseparable, the faying surface of going up sealing washer and lower sealing washer still can play good sealed effect.
Preferably, the upper surface of the upper sealing piece is inclined downwards from the periphery to the middle, the lowest point of the center of the upper surface of the upper sealing piece is formed with a round flat surface, and the edge of the flat surface passes through the center of the upper Y-shaped notch.
By adopting the technical scheme, when the swab penetrates through the penetrating sealing piece and goes deep into the eluent in the elution area, the swab is propped against the upper surface of the upper sealing piece and falls on the flat surface along the inclined surface of the upper sealing piece. In the process of applying force to the swab, the upper sealing sheet and the lower sealing sheet are driven to deform downwards to be opened together, so that the swab smoothly enters an elution area, and the swab is prevented from being clamped due to a double-layer sealing sheet structure with staggered notches.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the swab after sampling can be placed in the elution area, after a period of time, the inner box is moved to the position where the liquid inlet hole and the liquid outlet hole are opposite, so that the eluent enters the cavity and drops on the detection card through the detection connecting hole, and whether the sample is negative or positive can be judged after a period of time. The eluent is not required to be transferred between different devices in the whole process, so that the operation process is simplified.
2. A disinfectant accommodating cavity is formed at the bottom of the shell through separation of a bottom separation plate. When disinfection is to be performed after detection is finished, the weak opening can be punctured by the conical tip, so that disinfection liquid flows into the elution area to be mixed with the elution liquid for disinfection. No additional disinfection articles are needed, and the use is more convenient.
3. During the disinfection step, can press the top of detecting the box with force, stopper extrusion preforming is to both sides deformation this moment for interior box downward movement and puncture the weak mouth through the awl point. When the inner box moves downwards and the operation block is abutted with the lower side face of the indication hole, the positions of the transparent cover plate and the detection card cannot be changed, so that the result of the indication Kong Douqu can be still obtained at the moment, and the situation that the user needs to re-detect after the user finishes operating the detection card without keeping the detection result record is avoided.
Drawings
FIG. 1 is a schematic structural view of an embodiment;
FIG. 2 is a schematic cross-sectional view of an embodiment;
FIG. 3 is a schematic structural view of the housing;
fig. 4 is an enlarged view at a in fig. 2;
FIG. 5 is a schematic structural view of the cartridge;
FIG. 6 is a schematic view of the construction of the transparent cover plate and the test card;
fig. 7 is a schematic diagram of the layout structure of the inner case.
Reference numerals illustrate: 1. a housing; 2. a detection box; 3. a bottom separation plate; 4. a disinfectant containing cavity; 5. a weakened opening; 6. an upper partition plate; 7. a detection zone; 8. an elution zone; 9. a viewing window; 10. sealing cover; 11. perforating; 12. a wearable seal; 13. an annular groove; 14. an annular protrusion; 15. an upper sealing sheet; 16. a lower sealing sheet; 17. a lower Y-shaped notch; 18. a Y-shaped notch is formed; 19. an inner case; 20. a transparent cover plate; 21. a detection card; 22. a seal ring; 23. a cavity; 24. detecting a connecting hole; 25. a liquid inlet hole; 26. a liquid outlet hole; 27. a seal ring; 28. a groove; 29. a stop block; 30. a limiting block; 31. a limit groove; 32. tabletting; 33. an indication hole; 34. an operation block; 35. a conical tip; 36. and a limit column.
Detailed Description
The present application is described in further detail below in conjunction with figures 1-7.
The embodiment of the application provides a sampling, reaction and detection integrated device.
As shown in fig. 1, the integrated sampling, reaction and detection device comprises a housing 1 and a detection box 2 positioned in the housing 1.
As shown in fig. 2, the casing 1 is a hollow cylinder, a horizontal bottom separation plate 3 is formed in the casing 1 near the bottom, a disinfectant accommodating cavity 4 is formed by separating a space below the bottom separation plate 3 in the casing 1, and a circular weak opening 5 is formed in the bottom separation plate 3 near the inner side wall of the casing 1. In the initial state, the sterilizing liquid is sealed in the sterilizing liquid accommodating chamber 4, and when the weak opening 5 receives a large force, the bottom partition plate 3 is opened along the weak opening 5, so that the sterilizing liquid in the sterilizing liquid accommodating chamber 4 flows out.
As shown in fig. 3 and 4, an upper partition plate 6 is formed in the housing 1 at a position above the bottom partition plate 3 to divide the interior of the housing 1 in half in the vertical direction, with a distance being left between the lower end of the upper partition plate 6 and the bottom partition plate 3. The upper region of the housing 1 is divided into a detection zone 7 and an elution zone 8 by an upper partition plate 6, and the cartridge 2 is located in the detection zone 7. The part of the housing 1 corresponding to the elution zone 8 is provided with a window 9 made of transparent material, through which window 9 the eluent in the elution zone 8 can be observed. The housing 1 is provided with a sealing cover 10 at a position above the elution zone 8, a perforation 11 is formed on the sealing cover 10, and a penetrating sealing member 12 is arranged in the perforation 11, wherein the penetrating sealing member 12 is made of rubber or other materials capable of sealing deformation. An annular groove 13 is formed on the inner wall of the perforation 11, the cut-off surface of the annular groove 13 is square, an annular bulge 14 is formed on the circumference of the penetrable sealing piece 12 in a circle, the cut-off surface of the annular bulge 14 is semicircular, and the radius of the cut-off surface of the annular bulge is equal to the height of the annular groove 13. The middle part of the penetrating sealing member 12 is formed with an upper sealing plate 15 and a lower sealing plate 16 closely attached to the lower surface of the upper sealing plate 15, and both the upper sealing plate 15 and the lower sealing plate 16 are circular. The lower sealing piece 16 is provided with a lower Y-shaped notch 17, the center of the lower Y-shaped notch 17 is close to one side of the lower sealing piece 16, the upper sealing piece 15 is provided with an upper Y-shaped notch 18, and the center of the upper Y-shaped notch 18 is close to one side of the upper sealing piece 15 far away from the center of the lower Y-shaped notch 17. The upper surface of the upper sealing piece 15 is inclined downwards from the periphery to the middle, and the lowest point of the center of the upper surface of the upper sealing piece 15 is formed with a round flat surface, and the edge of the flat surface passes through the center of the upper Y-shaped notch 18.
As shown in fig. 3 and 4, the wearable seal 12 seals the elution zone 8 without being stressed, the notches formed on the seal piece have good sealing effect, and in the scheme, the upper Y-shaped notch 18 of the upper seal piece 15 and the lower Y-shaped notch 17 of the lower seal piece 16 are misplaced, so that the joint surfaces of the upper seal piece 15 and the lower seal piece 16 still have good sealing effect even if the matching of the notch positions is not tight enough. When the swab is passed through the penetrable seal 12 and into the eluent in the elution zone 8, the swab falls on a flat surface along the inclined surface of the upper sealing sheet 15 while resting against the upper surface of the upper sealing sheet 15. In the process of applying force to the swab, the upper sealing sheet 15 and the lower sealing sheet 16 are driven to deform downwards together to open, so that the swab smoothly enters the elution zone 8.
As shown in fig. 2, the cartridge 2 includes an inner case 19 located in the detection zone 7 with a distance between the bottom surface of the cartridge 2 and the bottom separation plate 3, and the region between the bottom surface of the cartridge 2 and the bottom separation plate 3 communicates with the elution zone 8. The detection box 2 comprises an inner box 19 with a semicircular cross section, a transparent cover plate 20 positioned on one side of the arc surface of the inner box 19 and a detection card 21 clamped between the inner box 19 and the transparent cover plate 20, wherein a sealing ring 22 surrounding the inner box 19 for a circle is sleeved at the lower end of the inner box 19, and a sealing surface is formed between the inner box 19 and the shell 1 through the sealing ring 22. The inner case 19 is formed with a cavity 23 inside, and a detection connection hole 24 communicating with the cavity 23 is formed at the bottom of the inner case 19 toward the side of the detection card 21, so that the liquid in the cavity 23 can be left on the detection card 21 through the detection connection hole 24. The inner box 19 is provided with a liquid inlet 25 communicated with the cavity 23 at a position close to the lower end on one side of the elution zone 8, the upper partition plate 6 is provided with a liquid outlet 26, and one side of the upper partition plate 6 facing the inner box 19 is embedded with a sealing ring 27 surrounding the liquid outlet 26. In the initial state, the liquid inlet 25 is positioned below the liquid outlet 26, and only when the positions of the liquid outlet 26 and the liquid inlet 25 are aligned, the eluent in the eluting region 8 can enter the inner box 19.
As shown in fig. 5 and 6, a groove 28 is formed in the side wall of the inner case 19 on the side far from the elution zone 8, the height of the groove 28 is larger than that of the transparent cover plate 20, and the width of the groove 28 is equal to that of the transparent cover plate 20, so that the transparent cover plate 20 can be embedded in the groove 28, and a distance is left between the upper end of the transparent cover plate 20 and the upper side wall of the groove 28. The upper and lower sides of transparent cover plate 20 are all extended to form to have dog 29 towards the direction in the recess 28, and when detecting card 21 set up between transparent cover plate 20 and interior box 19, the upper and lower both sides of detecting card 21 are spacing through dog 29, and the left and right sides of detecting card 21 is spacing through the inside wall of recess 28. Limiting blocks 30 are formed on the left side and the right side of the transparent cover plate 20 in an extending mode in the direction facing the grooves 28, and the extending distance of the limiting blocks 30 is larger than that of the stop blocks 29. As shown in fig. 7, the bottom surface of the groove 28 is formed with a limit groove 31 clamped into the limit block 30 at positions close to two sides, the width of the limit groove 31 is larger than that of the limit block 30, and the height of the limit groove 31 is larger than that of the limit block 30. The pressing sheets 32 which incline upwards from the two sides to the middle are formed at the positions, above the limiting blocks 30, on the two side walls in the limiting groove 31, and only when a large acting force is applied, the limiting blocks 30 can press the pressing sheets 32 to deform towards the two sides, so that the limiting blocks 30 reach the positions positioned between the two pressing sheets 32. As shown in fig. 1, a waist-shaped indication hole 33 is formed in one side of the detection area 7 of the housing 1, the indication hole 33 extends in the vertical direction, a circular operation block 34 is formed on the transparent cover plate 20, and the operation block 34 passes through the indication hole 33. CT indication marks are formed on the housing 1 at positions on the side surfaces of the waist-shaped indication holes 33.
As shown in fig. 5, the upper end of the case 1 on the side of the detection area 7 is penetrated, the upper end of the detection cartridge 2 exceeds the detection area 7, and the upper surface of the detection cartridge 2 is lower than the upper surface of the sealing cover 10 in the initial state. The upper port of the housing 1 on the side of the detection zone 7 is inclined downwards towards the side away from the elution zone 8. The bottom surface of inner box 19 just has conical tip 35 to the position shaping of weak mouth 5, and conical tip 35 can puncture weak mouth 5 when inner box 19 pushes down for disinfectant holds the antiseptic solution in the chamber 4 and flows out. The bottom surface of the inner box 19 is not aligned with the weak opening 5, and a limiting column 36 is formed, wherein the length of the limiting column 36 is shorter than that of the conical tip 35.
The specific using process comprises the following steps:
the swab is rotated deep into the nasal cavity for sampling and the sampled swab is then inserted into the elution zone 8 through the wearable seal 12. After the swab head is soaked in the eluent for a period of time, the detection box 2 is pushed upwards through the operation block 34 until the operation block 34 is abutted against the upper side face of the indication hole 33, the position of the liquid inlet hole 25 is opposite to the position of the liquid outlet hole 26, the elution area 8 is communicated with the cavity 23, and the eluent enters the cavity 23 and is dripped on the detection card 21 through the detection connecting hole 24 at the bottom of the cavity 23. During operation, the eluent can be observed through the window 9, when a plurality of small bubbles emerge from the surface of the eluent, the eluent can enter the cavity 23, and then the detection box 2 can be downward until the lower side edge of the operation block 34 and the lower side edge of the indication hole 33 are abutted, and the eluent can not enter the cavity 23 any more, so that the excessive eluent entering the cavity 23 is avoided.
After waiting a period of time, it can be interpreted by the indicator hole 33 as negative or positive. Then the upper end of the detection box 2 is pressed by force, at the moment, the limiting block 30 extrudes the pressing piece 32 to deform to two sides, so that the positions of the transparent cover plate 20 and the detection card 21 are unchanged, the inner box 19 downwards and pierces the weak opening 5 through the conical tip 35, and the disinfectant in the disinfectant containing cavity 4 enters the elution area 8 and is mixed with the eluent for disinfection.
The foregoing are all preferred embodiments of the present application, and are not intended to limit the scope of the present application in any way, therefore: all equivalent changes in structure, shape and principle of this application should be covered in the protection scope of this application.
Claims (7)
1. A sampling, reaction, detection integrated device, characterized by: the device comprises a shell (1) and a detection box (2), wherein an upper separation plate (6) which separates the interior of the shell (1) into a detection area (7) and an elution area (8) is arranged in the shell (1), the detection box (2) is positioned in the detection area (7), the detection box (2) comprises an inner box (19) which can move in the detection area (7), a transparent cover plate (20) positioned on one side of the inner box (19) far away from the elution area (8) and a detection card (21) positioned between the transparent cover plate (20) and the inner box (19), a cavity (23) is formed in the inner box (19), a detection connecting hole (24) which is communicated with the cavity (23) is formed at one side of the bottom of the inner box (19) facing the detection card (21), a liquid inlet hole (25) which is communicated with the cavity (23) is formed at one side of the inner box (19), a liquid outlet hole (26) is formed on the upper separation plate (6), a transparent cover plate (20) positioned on one side of the inner box (19) facing the upper separation plate (6) and a liquid outlet hole (27) is embedded and is attached to the inner box (19), and the liquid outlet hole (27) is formed at the position opposite to the liquid outlet hole (27) and comprises the liquid outlet hole (25); an indication hole (33) is formed in the shell (1), the length direction of the indication hole (33) is the same as the moving direction of the inner box (19), a groove (28) is formed in the side wall of one side, far away from the elution zone (8), of the inner box (19), a transparent cover plate (20) is embedded in the groove (28), an operation block (34) penetrating out of the indication hole (33) is formed in the transparent cover plate (20), and when the operation block (34) abuts against one side of the indication hole (33), the liquid inlet hole (25) is opposite to the liquid outlet hole (26); the upper separation plate (6) separates the shell (1) along the vertical direction, a bottom separation plate (3) is formed at a position, close to the bottom, in the shell (1) to separate the space at the bottom of the shell (1) into a disinfectant containing cavity (4), a circular weak port (5) is formed at the part, located below the detection area (7), of the bottom separation plate (3), the inner box (19) moves along the up-down direction, a conical tip (35) is formed at the position, close to the weak port (5), of the bottom surface of the inner box (19), and a sealing ring (22) abutted to the inner wall of the shell is sleeved on the outer side wall, close to one end of the formed conical tip (35), of the inner box (19); the utility model discloses a detection card, including casing (1), recess (28), limit plate (30) are located in recess (28), the upper end of casing (1) in detection area (7) one side link up, the width of recess (28) equals the width of transparent cover plate (20), the height of recess (28) is greater than the height of transparent cover plate (20), leave the distance between the upper end of transparent cover plate (20) and the upper lateral wall of recess (28), the upper and lower both sides face of transparent cover plate (20) in recess (28) one side all extend the shaping have limit plate (29) of upper and lower direction restriction detection card (21), the left and right sides of detection card (21) extend the shaping in the direction in recess (28) have stopper (30), the extension distance of stopper (30) is greater than the extension distance of stopper (29), the bottom surface of recess (28) is close to both sides position shaping have spacing groove (31) of cooperation stopper (30), the width of spacing groove (31) is greater than the width of stopper (30), the height of spacing groove (31) is greater than the height of stopper (30), the both sides that lie in stopper (30) on the lateral wall of spacing groove (31) are located in the both sides of stopper (30) and are upwards inclined from the position of middle (32).
2. The integrated sampling, reaction, and detection device of claim 1, wherein: and a limiting column (36) is formed at the position, which is not aligned with the weak opening (5), of the bottom surface of the inner box (19), and the length of the limiting column (36) is shorter than that of the conical tip (35).
3. The integrated sampling, reaction, and detection device of claim 1, wherein: the upper end of the detection box (2) exceeds the detection area (7), and the upper port of the shell (1) at one side of the detection area (7) is inclined downwards towards one side far away from the elution area (8).
4. The integrated sampling, reaction, and detection device of claim 1, wherein: the part of the shell (1) corresponding to the position of the elution zone (8) is made of transparent material and is provided with a window (9).
5. The integrated sampling, reaction, and detection device of claim 1, wherein: the shell (1) is provided with a sealing cover (10) at a position above the elution zone (8), a perforation (11) is formed on the sealing cover (10), and a wearable sealing piece (12) is arranged in the perforation (11).
6. The integrated sampling, reaction, and detection device of claim 5, wherein: the middle part shaping of wearable sealing member (12) has last sealing washer (15) and hugs closely lower sealing washer (16) at last sealing washer (15) lower surface, goes up sealing washer (15) and lower sealing washer (16) and all are circular, and the last shaping of lower sealing washer (16) has lower Y-shaped incision (17), and the center of lower Y-shaped incision (17) is close to one side of sealing washer (16), goes up sealing washer (15) and goes up shaping to have last Y-shaped incision (18), and the center of going up Y-shaped incision (18) is close to one side that upper sealing washer (15) kept away from lower Y-shaped incision (17) center.
7. The integrated sampling, reaction, and detection device of claim 6, wherein: the upper surface of the upper sealing piece (15) is inclined downwards from the periphery to the middle, and the lowest point of the center of the upper surface of the upper sealing piece (15) is formed with a round flat surface, and the edge of the flat surface passes through the center of the upper Y-shaped notch (18).
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| CN202310217883.0A CN116400076B (en) | 2023-03-07 | 2023-03-07 | Sampling, reaction and detection integrated device |
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