CN116392600A - 药物的眼部递送 - Google Patents
药物的眼部递送 Download PDFInfo
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- CN116392600A CN116392600A CN202310406885.4A CN202310406885A CN116392600A CN 116392600 A CN116392600 A CN 116392600A CN 202310406885 A CN202310406885 A CN 202310406885A CN 116392600 A CN116392600 A CN 116392600A
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- 239000006199 nebulizer Substances 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000000018 nitroso group Chemical group N(=O)* 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 238000001543 one-way ANOVA Methods 0.000 description 1
- 238000005192 partition Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229960001412 pentobarbital Drugs 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 1
- 229920000867 polyelectrolyte Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
- 229960005205 prednisolone Drugs 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 235000019832 sodium triphosphate Nutrition 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 229940032147 starch Drugs 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 125000000547 substituted alkyl group Chemical group 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- JSPLKZUTYZBBKA-UHFFFAOYSA-N trioxidane Chemical compound OOO JSPLKZUTYZBBKA-UHFFFAOYSA-N 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
- 238000007492 two-way ANOVA Methods 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1419540.8A GB201419540D0 (en) | 2014-11-03 | 2014-11-03 | Delivery of drugs |
| GB1419540.8 | 2014-11-03 | ||
| PCT/GB2015/053291 WO2016071677A1 (en) | 2014-11-03 | 2015-11-02 | Ocular delivery of drugs |
| CN201580072370.9A CN107106487A (zh) | 2014-11-03 | 2015-11-02 | 药物的眼部递送 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580072370.9A Division CN107106487A (zh) | 2014-11-03 | 2015-11-02 | 药物的眼部递送 |
Publications (1)
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|---|---|
| CN116392600A true CN116392600A (zh) | 2023-07-07 |
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| CN202310406885.4A Pending CN116392600A (zh) | 2014-11-03 | 2015-11-02 | 药物的眼部递送 |
| CN201580072370.9A Pending CN107106487A (zh) | 2014-11-03 | 2015-11-02 | 药物的眼部递送 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580072370.9A Pending CN107106487A (zh) | 2014-11-03 | 2015-11-02 | 药物的眼部递送 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10987304B2 (enExample) |
| EP (1) | EP3215119B1 (enExample) |
| JP (1) | JP6832276B2 (enExample) |
| CN (2) | CN116392600A (enExample) |
| CA (1) | CA2966592C (enExample) |
| GB (1) | GB201419540D0 (enExample) |
| WO (1) | WO2016071677A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2948134B1 (en) | 2013-01-24 | 2020-03-04 | Palvella Therapeutics, Inc. | Compositions for transdermal delivery of mtor inhibitors |
| IL267869B2 (en) | 2017-01-06 | 2023-10-01 | Palvella Therapeutics Inc | Non-aqueous preparations of mTOR inhibitors and methods of use |
| WO2019162951A1 (en) * | 2018-02-26 | 2019-08-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Drug delivery systems |
| JP2021530463A (ja) | 2018-07-02 | 2021-11-11 | パルヴェラ セラピューティクス、インク． | ｍＴＯＲ阻害剤の無水組成物および使用方法 |
| GB202007703D0 (en) * | 2020-05-22 | 2020-07-08 | Nanomerics Ltd | Amphiphilic carbohydrate compounds |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008017839A1 (en) * | 2006-08-09 | 2008-02-14 | The School Of Pharmacy, University Of London | Polymeric micellar clusters and their uses in formulating drugs |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0938896A1 (en) * | 1998-01-15 | 1999-09-01 | Novartis AG | Autoclavable pharmaceutical compositions containing a chelating agent |
| US6395756B2 (en) * | 1999-12-23 | 2002-05-28 | Novartis Ag | Use of ophthalmic agent |
| DE10242080A1 (de) * | 2002-09-11 | 2004-03-25 | Degussa Ag | Verfahren zur Katalysator-freien Herstellung von Cyanophenolen aus Methoxybenzonitrilen |
| GB0221941D0 (en) * | 2002-09-20 | 2002-10-30 | Univ Strathclyde | Polysoaps |
-
2014
- 2014-11-03 GB GBGB1419540.8A patent/GB201419540D0/en not_active Ceased
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2015
- 2015-11-02 EP EP15791351.8A patent/EP3215119B1/en active Active
- 2015-11-02 CN CN202310406885.4A patent/CN116392600A/zh active Pending
- 2015-11-02 CA CA2966592A patent/CA2966592C/en active Active
- 2015-11-02 WO PCT/GB2015/053291 patent/WO2016071677A1/en not_active Ceased
- 2015-11-02 CN CN201580072370.9A patent/CN107106487A/zh active Pending
- 2015-11-02 JP JP2017523822A patent/JP6832276B2/ja active Active
- 2015-11-02 US US15/524,079 patent/US10987304B2/en active Active
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2021
- 2021-03-26 US US17/213,805 patent/US20210212938A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008017839A1 (en) * | 2006-08-09 | 2008-02-14 | The School Of Pharmacy, University Of London | Polymeric micellar clusters and their uses in formulating drugs |
Non-Patent Citations (3)
| Title |
|---|
| ADELINE SIEW等: "Enhanced Oral Absorption of Hydrophobic and Hydrophilic Drugs Using Quaternary Ammonium Palmitoyl Glycol Chitosan Nanoparticles", 《MOLECULAR PHARMACEUTICS》, vol. 09, 2 November 2011 (2011-11-02), pages 3 - 9 * |
| 刘松青等主编: "《实用药物手册》", vol. 2007, 31 October 2007, 四川大学出版社, pages: 521 * |
| 赵晓亮等: "壳聚糖胶束作为环孢素A眼部传递的载体", 《中国药科大学学报》, vol. 43, no. 05, 25 October 2012 (2012-10-25), pages 418 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107106487A (zh) | 2017-08-29 |
| GB201419540D0 (en) | 2014-12-17 |
| EP3215119A1 (en) | 2017-09-13 |
| EP3215119B1 (en) | 2021-03-10 |
| CA2966592A1 (en) | 2016-05-12 |
| JP2017533228A (ja) | 2017-11-09 |
| US20170326064A1 (en) | 2017-11-16 |
| CA2966592C (en) | 2023-03-07 |
| JP6832276B2 (ja) | 2021-02-24 |
| WO2016071677A1 (en) | 2016-05-12 |
| US10987304B2 (en) | 2021-04-27 |
| US20210212938A1 (en) | 2021-07-15 |
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