CN1163751A - External skin-care composition - Google Patents

Abstract

The invention discloses an external use skin-care compound which contains plant extract A and amine derivative B represented by acid heteropolysaccharide derived from callus of tuberose plant and/or formula (1), wherein, R<1> in formula (1) refers to alkyl group which can contain heteroatom; R<2>-R<6> independently refers to hydrogen atom or alkyl group; X refers to -O- or -CO-O-. The external use skin-care compound has excellent efficacies in preventing the skin from aging, such as improving the coarseness of skin and stretching wrinkles.

Description

External skin-care composition

The present invention relates to a kind ofly preventing skin aging, as at the skin of preserving moisture, prevent and improve pachylosis, wrinkle resistant and unfold the external skin-care composition that has excellent effect aspect the wrinkle of skin.

In recent years, keep fit and skin attractive in appearance has been the very problem of care of old and young institute irrespective of sex.Yet skin can be subjected to influences such as age and temperature, humidity, ultraviolet, cosmetic composition, disease, operating pressure, dietary habit and delicate variation takes place.So; this variation meeting brings all puzzlements to the people; as the various functions of the skin decline and the old and feeble appearance of (prevent to lose the moisture of regulating organism temperature etc., the protection body is avoided the intrusion of physics and chemical stimulation and extraneous antibacterial and the functions such as skin elasticity of decision skin surface form).

In addition, in body, cause the skin histology functional disorder with extrinsic factor, cause that it also may be owing to some factors that act on body that skin changes the puzzlement that is brought, as external environment condition (seasonal variations, ultraviolet etc.) and with aforesaid aging and disease and pachyderma that brings out therefrom and the unusual physiological function change that produces of skin keratin etc.

Change the puzzlement that is brought and did trial preventing and reducing this class skin, as on skin, smearing synthetic or natural wetting agent, preventing xerosis cutis and to improve the moisture-retaining capacity of skin, thereby or on skin, smear the circulation of blood circulation accelerator accelerate blood.

That is to say, be furnished with one or more wetting agents by employing, prevent from and reduce above-mentioned skin to change the puzzlement aspect of being brought and done effort as the drug effect external skin-care composition of free amino acid, organic acid, carbamide, inorganic ions and polysaccharide (as hyaluronic acid), animal and plant extract, vitamin and derivant thereof, peptide, protein, hydroxy acid etc. and/or cosmetic composition.

But even the conventional component of this class is coated on the skin, its effectiveness also is low and temporary transient, changes the puzzlement that is brought so this class component can not fundamentally prevent and improve skin.

On the other hand, to change the wrinkle cause one of puzzlement be that the corium that caused by people's aging, dry, ultraviolet etc. is old and feeble and take place to skin.More precisely, skin aging be because extraneous physics and chemical factor (as dry and ultraviolet) stimulate and since the variation of the epidermal surface form that the dermal tissue decline that aging, disease and operating pressure produce etc. cause cause, specifically, the decline of corium is meant the most of forfeiture of collagen fiber, subcutaneus adipose tissue minimizing etc. in the corium, and this species impoverishment is that skin forms wrinkle, main cause loose and that follow the string takes place skin.

Before this, for preventing or unfolding the wrinkle that causes because of skin aging, various compositionss and method had been proposed.Referring to Japanese Unexamined Patent Publication No 185005/1987,502546/1987,72157/1990 and 288822/1990 etc.

Yet these compositionss also do not obtain satisfied effect to the unfolding of wrinkle resistant and wrinkle of skin.

Therefore the purpose of this invention is to provide a kind of to preventing that skin aging has excellent effect, as moistening skin effect, prevent and improve pachylosis effect and wrinkle resistant and unfold the external skin-care composition of wrinkle effect.

In view of the foregoing, the present inventor has carried out extensive studies.Therefore, have found that, the sour heteropolysaccharide that obtains when plant extract and the callus that belongs to (Polianthes L.) plant from a kind of Polianthes tuberosa L. and/or with the amine derivative (will be illustrated below) of general formula 1 expression composite obtain a kind of to preventing that the corium aging has the external skin-care composition of collaborative reinforced effects.Thereby realized purpose of the present invention.

Comprise following component (A) and (B) according to external skin-care composition provided by the invention:

(A) plant extract; And

(B) one or more are selected from by the derive sour heteropolysaccharide (b-1) that obtains and with the component of the amine derivative (b-2) of general formula (1) expression of the callus of Polianthes tuberosa L. platymiscium: R in the formula ¹Be straight chain, side chain or the annular hydrocarbyl group that contains 1-40 carbon atom, can be replaced, or contain 1-5 carbon atom and heteroatomic alkyl by at least one hydroxyl; R ², R ³, R ⁴, R ⁵And R ⁶Be identical or differ from one another independently of one another for hydrogen atom or for containing the hydrocarbyl group of 1-20 carbon atom, can be replaced by at least one hydroxyl, X is-O-or-CO-O-, but be incorporated into R with carbonyl bond ¹Be condition, or the acid-addition salts of (1).

According to external skin-care composition of the present invention, preventing skin aging, as preserving moisture, preventing and improve pachylosis, wrinkle resistant and unfold and have excellent effect aspect the wrinkle at skin.

According to following explanation and appending claims, above-mentioned and other purpose, form and advantage of the present invention are conspicuous.

The example that is used for plant extract component of the invention process (A) comprises the extract that obtains from following plant: as Radix Rubiae, strand Radix Angelicae Sinensis (Angelica keiskei), Semen Phaseoli, American Avocado Tree, the rust globe daisy, Herb Gynostemmae Pentaphylli (Gynostemma pentaphyllum), ARUTEKA, Arnica montana, Semen Armeniacae Amarum, the reed Chinese juniper, Fructus Pruni, Herba Urticae Cannabinae, Rhizoma Iridis Tectori, Fructus Foeniculi, Rhizoma Curcumae Longae, EIJITSU, scutellariae,radix, the Heilungkiang softwood trees, KAKKO, KANSUI, Fructus Kaki, Japan's Semen Castaneae, Rhizoma Coptidis, Fructus Hordei Vulgaris, Flos abelmoschi manihot, St. John's plant, Herba lamii barbati, ONONISU, ENMEIGUSA, Herba Oenanthes Javanicae, the root of Kudzu, Valeriana Fauriei Briq. (Valeriana fauriei), birch, Herba Typhae, Anthemis nobilis, Rhizoma Alpiniae Officinarum, peeling Herba Tagetis Patulae (Chamomilla), Herba bromi japonici, Radix Glycyrrhizae, Fructus Rubi, Fructus actinidiae chinensis, Fructus Cucumidis sativi, Fructus Pruni, Cortex cocois radicis, Fructus Gardeniae, white edge red bamboo (Sasa albo-marginata), Semen Juglandis, Cortex Cinnamomi, sorosis, GUNJO, Radix Gentianae, Herba Erodii, Fructus Arctii, Semen Sesami, Semen Tritici aestivi, rice, Camellia sasanqua Thunb. (Camellia sasanoua), Stigma Croci, the chrysanthemum fruit, Symphytum officinale, pharmacognosia, Rhizoma Zingiberis Recens, Fructus Crataegi, Japan Fructus Piperis tree, mushroom, purple Radix Rehmanniae (Rehmannia glutinosa), prop root, beefsteak plant (beefsteak plant), the Japan bodhi, many to palmate meadowsweet (Filipendula multijuga), the China Paeonia suffruticosa, Rhizoma Zingiberis Recens, Rhizoma Acori Graminei, Betula platyphylla Suk. wood, the Japan woodbine, wild Herba Equiseti Hiemalis, Folium Stevlae Rebaudianae (Stevia rebaudiana Bertoni), Caulis et Folium Brassicae junceae, Hedera nepalensis var.sinensis, the west Fructus Crataegi, Ramulus Sambuci Williamsii, the needle cypress, leafy Millefolium, Herba Menthae, Salvia japonica Thunb., common Radix Malvae sylvestris, Japan's Rhizoma Chuanxiong (Cnidium officinale), atractylodes japonica (Atractylodes japonica), SENGAKUSO, SENKINSHI, the bright Radix Gentianae of Japan, Semen sojae atricolor, DAISO, Herba thymi vulgaris, the tea plant, Flos Caryophylli, dried Pericarpium Citri junoris, night primrose, Flos Camelliae Japonicae, Herba Centellae (Centella asiatica), Britain's Semen Juglandis, east Radix Angelicae Sinensis (Angelica acutiloba), Flos Inulae, Radix Ginseng, Pericarpium Citri junoris, corn, Herba Houttuyniae (Houttuynia cordata), Fructus Lycopersici esculenti, Radix Dauci Sativae, Bulbus Allii, wild rose, Fructus Hordei Germinatus, parsley, rye (Secale cereale L.), the soft grit Semen Coicis, cornmint, Fructus Chaenomelis, Radix Hamamelidis Mollis, Flos Rosae Rugosae, Bai Xuesong, Helianthi, Folium Eriobotryae, Petasites officinalis Moench, Herba Taraxaci, Fructus Vitis viniferae, Placenta Hominis, Semen coryli heterophyllae, Fructus Luffae, Flos Carthami, bodhi tree, Flos lupuli (Flos Humuli Lupuli), macadamia nut, pine, Aesculus chinensis Bunge, Herba Melissae officinalis, melilotus, peach, Folium Persicae, Fructus Hordei Germinatus, Rodger copper leaf, Petiolus Trachycarpi, Eucalyptus, Herba Saxifragae crawls, Bulbus Lilii, YOKUININ, Radix Artemisia ordosicae, rye (Secale cereale L.), Semen arachidis hypogaeae, Garden lavender, Fructus Mali pumilae, Fructus Litchi, Caulis et Folium Lactucae sativae, Fructus Citri Limoniae, the Radix Astragali, RENSENGUSO, Herba Rosmarini Officinalis, Chamomile, Radix Agrimoniae, the Japan Catalpa ovata Don., hiba arborvitae, HORUTOSO, white pubescence Herba Rabdosiae glaucocalycis (Isodon japonicusHara), KIJITSU, SENKISHI, Herba stellariae mediae, Herba Spirodelae, Radix Artemisia ordosicae, Semen Ginkgo, the China Canterburybells, Flos Chrysanthemi, Fructus Sapindi Mukouossi, and Fructus Forsythiae

These extracts that extract from Radix Agrimoniae, Japanese Catalpa ovata Don., hiba arborvitae, HORUTOSO, white pubescence Herba Rabdosiae glaucocalycis, KIJITSU are that the present invention is particularly preferred.

Can grind as exsiccant or undried leaf, peel of stem, root and branch by putting in order in strain plant or the plant part or many parts (hereinafter referred to as " raw material ") respectively, extract and obtain the extracts of these plants at room temperature or high temperature then or with solvent or with extractor (as Soxhlet's extractor).Solvent of the present invention is had no particular limits.The example of solvent comprises solvent such as water, primary alconol (as methanol and ethanol), liquid polyol (as propylene glycol and 1,3 butylene glycol), lower alkyl esters (as ethyl acetate), hydro carbons (as benzene and hexane), ether and the acetone of knowing.These solvents can use separately or composite by any way use.

Preferred specific embodiment as the raw material abstraction method is to add 1000 milliliter of 50 volume in the dry ground raw material of 100 grams, at room temperature extracts 3 days, is stirred at any time.Filter the gained extract, filtrate was left standstill under 5 ℃ 3 days, and then filtered, and obtained the supernatant thus.Though the solution state the when plant extract that obtains under these conditions can extract uses, also can be as required, through concentrate, filtration and/or method like that handle after use.

Can use separately or use as the plant extract of component (A) with their any compound.Compositions (A) adding proportion is that the dry solid content (based on composition total weight) of 0.0001-20 (weight) % (hereinafter only representing with %) is preferred.Preferred adding proportion is 0.0001-10%, particularly preferred ratio is 0.0001-5%, because preventing that in the resulting external skin-care composition of this ratio corium from having better effect aspect old and feeble, and saying to have advantages of excellent stability from aspects such as color and luster, abnormal smells from the patients.

Be used for component of the invention process (B), the sour heteropolysaccharide (b-1) (hereinafter referred to as " acid polysaccharide ") that obtains by the callus of Polianthes tuberosa L. platymiscium can be according to method described in the Japanese Unexamined Patent Publication No 10997/1989 by the callus of obtaining in the Polianthes tuberosa L. platymiscium by cultivating, from culture medium, collect again and get.Polianthes tuberosa L. (Polianthes tuberoseL.) is the preferred embodiment as the Polianthes tuberosa L. platymiscium that can mention.

For example, for Polianthes tuberosa L., can carry out the collection of acid polysaccharide according to following method for tissue culture.That is, a Polianthes tuberosa L. such as flower are as explant and 10 ^-5M auxin and 10 ^-6The M basic element of cell division is added in the Linsmaier-skoog basal medium as phytohormone.In addition, with 3% sucrose as carbon source.The culture medium that the prepares cultivation of going down to posterity again after the callus that is used to derive, and shake with the fluid medium with the culture medium same composition that is used in callus culture and to close cultivation., with centrifugal, filtration or like that method from culture fluid isolate cell, and concentrate remaining culture fluid with class methods with rotary evaporator or other thereafter.Add solvent such as ethanol or acetone with precipitated product to the concentrated solution that obtains.Lyophilization precipitate then, thus separate and collected acid polysaccharide.

When acid polysaccharide added in the compositions as component (B), its additional proportion was that 0.0001-20% (in composition total weight) is preferred.Preferred additional proportion is 0.001-10%, especially is 0.01-10%, because preventing that in the resulting external skin-care composition of this ratio corium has more satisfied effect aspect old and feeble.

For component (B), amine derivative (b-2) is represented by general formula (1).In the general formula (1) by R ¹Expression, the straight chain that contains 1-40 carbon atom, the example of side chain or cyclic hydrocarbon group comprises alkyl group, as methyl, ethyl, propyl group, butyl, amyl group, hexyl, heptyl, octyl group, nonyl, decyl, undecyl, dodecyl, tridecyl, myristyl, pentadecyl, cetyl, heptadecyl, octadecyl, nonadecyl, eicosyl, heneicosyl, docosyl, tricosyl, tetracosyl, pentacosyl, cerul, heptacosyl, octacosyl, nonacosyl, melissyl, hentriacontyl, dotriacontyl, tritricontyl, the tetratriacontane base, the pentatriacontane base, the hexatriacontane base, the heptatriacontane base, three octadecyls, the nonatriacontane base, tetracontyl, iso stearyl, the iso stearyl of methyl branch, the 2-ethylhexyl, 2-heptyl undecyl, 5,7,7-trimethyl-2-(1,3,3-trimethyl butyl) octyl group and isopropyl group; Kiki alkenyl group, as vinyl, pi-allyl, cyclobutenyl, pentenyl, hexenyl, 9-vaccenic acid base and 9,12-18 carbon dialkylene groups; Alicyclic hydrocarbon group is as cyclopropyl, cyclobutyl, cyclopenta and cyclohexyl groups; Aromatic hydrocarbon group is as phenyl, naphthyl, tolyl, xylyl and benzyl group; And as the hydrocarbyl group of cholesteryl.

By R ¹These hydrocarbyl groups of expression can be replaced by one or more oh group.The example of the substituted alkyl of this class comprises methylol, ethoxy, hydroxypropyl, hydroxyl hexyl, hydroxyl stearyl, 2,3-dihydroxypropyl and 2, two (the methylol)-3-hydroxypropyl groups of 2-.

By R ¹Containing in 1-5 carbon atom and the heteroatomic hydrocarbyl group of expression, heteroatomic example comprises oxygen, nitrogen, sulfur, phosphorus and fluorine atom.The example that contains the heteroatomic hydrocarbyl group of this class comprises glycosyl, carboxymethyl, amino carbonyl methyl and 1-(N, N dimethylamino) ethyl group.

By R ², R ³, R ⁴, R ⁵And R ⁶The alkyl example that contains 1-20 carbon atom of expression comprises alkyl, as alkyl group, iso stearyl, 2-ethylhexyl, 2-heptyl undecyl, 5 as methyl, ethyl, propyl group, butyl, amyl group, hexyl, heptyl, octyl group, nonyl, decyl, undecyl, dodecyl, tridecyl, myristyl, pentadecyl, cetyl, heptadecyl, octadecyl, nonadecyl, eicosyl, methyl branch, 7,7-trimethyl-2-(1,3,3-trimethyl butyl) octyl group and isopropyl group; Kiki alkenyl group, as vinyl, pi-allyl, cyclobutenyl, pentenyl, hexenyl, 9-vaccenic acid base and 9,12-18 carbon dialkylene groups; The alicyclic hydrocarbon radical group is as cyclopropyl, cyclobutyl, cyclopenta and cyclohexyl groups; And aromatic hydrocarbon group, as phenyl, naphthyl, tolyl, xylyl and benzyl group.

By R ²-R ⁶These hydrocarbyl groups of expression can be replaced by one or more oh group.This class examples of groups comprises methylol, 2-ethoxy, 2-hydroxypropyl, 1,2-dihydroxy ethyl, 1,2,3-trihydroxy propyl group, 1,2,3-trihydroxy butyl, 1,2,3,4-tetrahydroxy butyl, 1,2,3,4-tetrahydroxy amyl group and 1,2,3,4,5-penta hydroxy group pentyl group.

In the ammonia derivant by general formula (1) expression, R in the formula ¹Be the alkyl group that contains 1-36 carbon atom, and can be by at least one oh group replaced; X is-O-and R ², R ³, R ⁴, R ⁵And R ⁶For hydrogen atom is particularly preferred.

The amine derivative (1) that is used for the invention process is synthetic according to various known method.For example, can come synthetic with amine derivative (3) by following reaction equation reaction by glycidyl ether or ester derivant (2):

R in the formula ¹, R ², R ³, R ⁴, R ⁵And R ⁶Identical with afore mentioned rules.

The amine derivative that makes thus, can change inorganic acid salt into hydrochloric acid, sulphuric acid, nitric acid or phosphoric acid by methods known in the art as required, or change acylate into succinic acid, fumaric acid, hexadecanoic acid, octadecanoid acid, lactic acid, glycolic, citric acid, tartaric acid or benzoic acid.

As amine derivative (1), 1-(2-hydroxyethylamino)-3-iso stearyl oxygen-2-propanol, 1-(2-hydroxyethylamino)-3-(12-hydroxyl stearyl oxygen)-2-propanol and 1-(2-hydroxyethylamino)-3-methoxyl group-2-propanol are particularly preferred.

When the salt of amine derivative or itself and sour addition was added in the compositions as component (B), its additional proportion was that 0.0001-20% (in composition total weight) is preferred.Preferred additional proportion is 0.001-10%, especially is 0.01-5%, prevents that the old and feeble aspect of corium has better effect because be combined in the external-use skin care of this ratio gained.

By the way, one or more components that are selected from the salt (b-2) that sour heteropolysaccharide (b-1) and amine derivative or itself and acid form are as component (B).The salt (b-2) that adopts sour heteropolysaccharide (b-1) and amine derivative or itself and acid to form is mutually composite to be particularly preferred.In this case, the total amount of allocating into of this component is preferred with 0.0001-20%, especially is 0.001-10% (in the gross weight of compositions).

According to external skin-care composition of the present invention, can be divided into drug effect external skin-care composition and cosmetic composition roughly from use angle.Every kind of compositions all can prepare according to methods known in the art.

Example as the drug effect external skin-care composition can should be mentioned that the ointment that contains the medicine composition.This ointment can comprise with oil base as the agent base with oil/water or water/oil emulsion two classes as the agent base.Oil base is not had special restriction, and for example vegetable oil, animal oil, synthetic oils, fatty acid, natural and synthetic glyceride, N-fatty acyl group sphingosine, false N-fatty acyl group sphingosine etc. all can adopt.Also do not have special restriction for ingredient, for example, analgesic and antibiotic medicine, pruritus, disinfectant, astringent, softening agent, hormone etc. all are suitable for as required.

As cosmetic composition, can be mixed with the skin care cosmetic compositions of various forms, comprise as water/oil or oil/water emulsified make-up, cream frost, cosmetic washing liquid, floral water, essential oil; Oily cosmetics, skin lotion, lip pomade, vanishing cream, skin clean compositions, hair nutrient, hair setting composition, hair modifying composition, hair growth promoter etc.

As the composition of cosmetic composition except basis; can suitably add those compositions that are generally used in traditional cosmetics; for example surfactant, oily material, polysiloxanes, sterol, N-fatty acyl group sphingosine, false N-fatty acyl group sphingosine, polyhydric alcohol, powder, polysaccharide, aminoacid, film former, antiinflammatory, creating singlet oxygen by using scavenger or antioxidant, pH regulator agent etc., only otherwise effect of the present invention is produced all can adding of adverse effect.

As surfactant, any non-ionic surface active agent, anion surfactant and amphoteric surfactant all are suitable for.

The example of non-ionic surface active agent comprises polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene fatty acid ester, fatty acid esters of sorbitan, polyoxyethylene sorbitan fatty acid ester, Polyoxyethylene Sorbitol Fatty Acid Esters, glycerine monofatty ester, polyoxyethylene hardened castor oil, the polyoxyethylene hardened castor oil alkyl sulfate, polyxyethylated sulfuric ester, polyglyceryl fatty acid ester, fatty acid cane sugar ester, fatty glyceride, alkyl phosphate, polyxyethylated phosphate ester, fatty acid alkali metal salt and alkyl glycerol base ether.Wherein, the glyceryl ether of preferably representing with following general formula (4):

R in the formula ⁷It is the alkyl of 8-24 carbon atom.Particularly preferably be R in the general formula (4) ⁷With the glyceryl ether of following formula (5) expression,

P is that 4-10 integer value, q are the 5-11 integer values in the formula, and p+q is 11-17, and the peak value of distribution is at q=8.

The anion surfactant example comprises the alkylbenzenesulfonate of straight or branched; straight or branched alkyl (or alkenyl) ether sulfate; alkyl or alkenyl sulfate with alkyl or alkenyl; alkene sulfonate; alkane sulfonate; unsaturated fatty acid salt; alkyl (or alkenyl) ether carboxylate; alpha-sulfo-fatty acid salt or ester with alkyl or kiki alkenyl group; have the N-acylamino-acid type surfactant of carboxyl groups and free carboxy acid's residue and have alkyl or a list of kiki alkenyl group-or diphosphate.

Examples of amphoteric surfactants comprise have alkyl, imidazoline type amphoteric surfactant and carboxybetaine, amido betaines, sulfobetaines, hydroxyl sulfo betaine and the acylamino-sulfobetaines type amphoteric surfactant of alkenyl or acyl group.

These surfactants can use separately or composite in any form use.When adding these surfactants, its adding proportion is that 0.01-20% is preferred, specifically, is 0.1-5% (in composition total weight).

Be used for oily material of the present invention and have no particular limits, the example comprises hydro carbons, as solid-state or liquid paraffin, vaseline, crystal oil, ceresin, ceresine, montanin wax, squalane and Squalene; Ester oil such as Eucalyptus oil, hardened palm oil, Oleum Cocois, Oleum menthae, Radix Oenotherae erythrosepalae oil, Cera Flava, Camellia oil, almond oil, cocoa butter, Oleum Ricini, Oleum sesami, Queensland's fruit oil, Oleum Helianthi, Oleum Arachidis hypogaeae semen, abocado oil, Adeps Bovis seu Bubali, leaf fat, horse fat, egg yolk fat, olive oil, Brazil wax, lanoline, hydrogenated lanolin, Simmondsia chinensis oil, glyceryl monostearate, distearin, glyceryl monooleate, Palmic acid myristyl ester, the Palmic acid cetyl ester, 16-hydroxy-palmitic acid cetyl ester, the isooctyl acid cetyl ester, isopropyl palmitate, the Palmic acid isobutyl ester, isopropyl stearate, butyl stearate, stearic acid isocetyl ester, isopropyl myristate, myristic acid 2-octyl group dodecyl ester, lauric acid hexyl ester, isopropyl laurate, decyl oleate, two capric acid DOPCP, diethyl phthalate, lactic acid myristyl ester, diisopropyl adipate, the adipic acid cetyl ester, the myristic acid cetyl ester, lactic acid myristyl ester, malic acid two iso stearyl esters, diisopropyl adipate, the myristic acid cetyl ester, the lactic acid cetyl ester, 1-isostearoyl-3-myristoyl glycerol, the 2 ethyl hexanoic acid cetyl ester, Palmic acid 2-Octyl Nitrite, myristic acid 2-octyl group dodecyl ester, two-2 ethyl hexanoic acid DOPCP, oleic acid 2-octyl group dodecyl ester, three isostearic acid glyceride, two-right-methoxy cinnamic acid list-2 ethyl hexanoic acid glyceride, tetramethylolmethane four esters, triglyceride and three-2 ethyl hexanoic acid glyceride; Higher fatty acids, as stearic acid, oleic acid, octadecadienoic acid, isostearic acid, myristic acid, palmitoleic acid, castor oil acid, lauric acid and the hydroxy fatty acid that hydroxyl is arranged on the alkyl of these fatty acids, and Palmic acid; Higher alcohol, as benzyl alcohol, 2-Methylpentadecane alcohol, isooctadecane alcohol, tadenan, hexadecanol, phenylethanol, spermol, octadecanol, oleyl alcohol, 2-octyldodecanol, palmityl alcohol and 2-hexyldecanol; And the sphingol derivant and the synthetic (as glycosyl N-fatty acyl group sphingosine, glactosyl N-fatty acyl group sphingosine, N-fatty acyl group sphingosine etc.) thereof of phospholipid, natural extract.These oily materials can use separately or composite by any way use.

When adding these oily materials, its adding proportion is preferred with 0.001-50%, is preferably 0.005-30% (in composition total weight) especially.

Just allocate the polysiloxanes in traditional cosmetic composition usually into, be used for not being particularly limited when of the present invention, their example comprises the prestox polysiloxanes, ten tetramethyl polysiloxanes, methyl polysiloxane, high polymeric methyl polysiloxane, and methyl phenyl silicone, also has methyl cyclo(poly)siloxane class, as octamethylcy-clotetrasiloxane and decamethylcyclopentaandoxane, the siloxanes of trimethylsiloxy group silicic acid and modification is as polyether-modified siloxanes, the siloxanes of the siloxanes oxazolyl modification of polyoxyalkylene alkyl modification, the siloxanes of alkyl glycerol base ether modification and at the organopolysiloxane of the special modification described in the Japanese Unexamined Patent Publication No 72851/1994.

When allocating these polysiloxanes into, their ratios in cosmetic composition can be determined according to the compositions form of preparation.But their allocation ratio is preferred with 0.001-50%, especially is 0.005-30% (in composition total weight).

The example of sterol comprises cholesterol, the cholesterol isostearate, vitamin D3 is former, campesterol, stegma stanol (Stegmastanol), the stegma sterol, the 5-dihydrocholesterol, hitodesterol, palysterol, chionasterol, clionasterol, stegma steroid enol, the Alga Sgrgassi Enerves sterol, apenasterol, ergostanol, sitosterol, colubisterol, chondrillasterol, polyphellasterol, haliclonasterol, neospongosterol, 24-ethylidenecholest-5-en-3.beta.-ol., aptostanol, amphisterol, ergosterol, 22-dihydroergosterol, brassicasterol, the 24-methylenecholesterol, the 5-dihydroergosterol, the dehydrogenation ergosterol, fungisterol, Dihydrocholesterol, coprostanol, kryptosterol, 7-Cortex Cinnamomi cholesterol, 7-cholene alkanol, the 22-dehydrocholesterol, cupreol, cholestatriene-3 β-alcohol, coprostenol, cholestenol, ergostenol, the 7-dehydrocholesterol, 24-dehydrogenation gallbladder steroid diketone-3 β-alcohol, equilenin, equilin, estrone, 17 beta estradiols, androstane-4-alkene-3 β, 17-isoallopregnane-3, dehydroepiandrosterone and cholesterol alkenyl succinate (Japanese Unexamined Patent Publication No 294989/1993).These sterols can use separately or composite by any way use.

Wherein, cholesterol, cholesterol isostearate and cholesterol alkenyl succinate are particularly preferred.

When allocating these sterols into, their allocation ratio is preferred with 0.001-50%, is preferably 0.005-30% (in composition total weight) especially.

The N-fatty acyl group sphingosine can extract from brain or from skin and purification, or synthetic by chemical method.For example can adopt in the synthetic method described in Japanese Unexamined Patent Publication No 7118/1984 and the International Patent Publication No. WO 93/22281.

Particularly preferred N-fatty acyl group sphingosine example comprises N-oleoyl-sphingol, N-(12-hydroxyl octadecanoyl)-sphingol, N-(16-hydroxyl hexadecanoyl group) sphingol and Medulla Bovis seu Bubali N-fatty acyl group sphingosine.

False N-fatty acyl group sphingosine comprises those products according to the preparation of method described in Japanese Unexamined Patent Publication No 228048/1987 and 216852/1988.Particularly preferred false N-fatty acyl group sphingosine example comprises the chemical compound with following general formula (6) and (7) expression:

R in the formula ⁸Be the alkyl of a tool 9-17 carbon atom, R ⁹It is alkyl with 10-18 carbon atom;

R in the formula ¹⁰And R ¹¹Be identical or mutually different, independently of one another for to have the hydrocarbyl group of 1-40 carbon atom, and can be hydroxylated, R ¹²Be straight or branched alkylidene group or singly-bound with 1-6 carbon atom, R ¹³Be hydrogen atom, have the straight or branched alkoxy base or 2 of 1-12 carbon atom, 3-dihydroxy propoxyl group group, but need with R ¹²R when being singly-bound ¹³Be that hydrogen atom is a condition.

When allocating these N-fatty acyl group sphingosines or false N-fatty acyl group sphingosine into, their allocation ratio is preferred with 0.001-20%, is preferably 0.001-10% (in composition total weight) especially.

Have no particular limits being used for polyhydric alcohol of the present invention, the example comprises glycerol, polyglycereol such as diglycerol, triglycerin and four glycerol, ethylene glycol, 1,3-butanediol, 1,4-butanediol, propylene glycol, dipropylene glycol, Polyethylene Glycol, 1, the alcohol that ammediol, glucose, maltose, maltose alcohol, sucrose, fructose, xylitol, sorbitol, maltotriose, threitol, erithritol, the alcohol, sorbitol and the reduction of polyoxyalkylene alkylglycoside that obtain by the amylum hydrolysate of the sugar reduction obtain.Wherein, glycerol, 1,3 butylene glycol and 1, ammediol is particularly preferred.

When allocating these polyhydric alcohol into, their allocation ratio is preferred with 0.001-50%, and more preferably 0.01-30% most preferably is 0.1-20% (in composition total weight).

Just allocate the powder in traditional cosmetic composition usually into, be used for being not particularly limited when of the present invention, their example comprises inorganic powder, as Muscovitum, iron oxide red, Bismuth Oxychloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, iron oxides, ultramarine blue, ferrum orchid, chromium oxide, chromic oxide gel, Calamina, zeolite and the carbon black of silicic acid, silicic acid anhydride, magnesium silicate, Talcum, Kaolin, Muscovitum, bentonite, cladding titanium dioxide; Various resin powders are as polyamide, polyester, polyethylene, polypropylene, polystyrene, polyurethane, vinyl, carbamide resin, phenol resin, fluororesin, polyorganosiloxane resin, acrylic resin, melmac, epoxy resin, polycarbonate resin and divinylbenzene-styrol copolymer and the copolymer resin powder be made up of two or more resins in them; Organic powder is as celluloid, acetylcellulose, polysaccharide, protein, scleroprotein; Various organic toner powders are as red No.201, red No.202, red N0.204, red No.205, red No.220, red No.226, red No.228, red No.405, orange No.203, orange No.204, yellow No.204, yellow No.401 and blue No.404; The colorant powder of being made up of zirconium, barium or aluminum color lake or this type of color lake is as red No.3, red No.104, red No.106, red No.227, red No.230, red No.401, red No.505, orange No.205, yellow No.4, yellow No.5, yellow No.202, yellow No.203, green No.3 and blue No.1; And metallic soap, as magnesium stearate, calcium stearate, Dodecanoic acid, zinc salt and Hexadecanoic acid, zinc salt.These powders before use can be through surface treatment, as carrying out siloxane treated with methyl hydrogen methyl polysiloxane, trimethyl silica silicic acid, methyl polysiloxane etc.; Carrying out fluorine with perfluoralkyl phosphate (salt), perfluor alcohol or this type of fluoride handles; Carrying out aminoacid with N-acyl glutamic acid or this compounds handles; Lecithin processing, metallic soap processing, fatty acid treatment or alkyl phosphate (salt) are handled.These powders also can two or more composite uses.

When allocating these powders into, their ratios in cosmetic composition can be determined according to the compositions form of preparation.But their allocation ratio is preferred usually with 0.001-50%, is preferably 0.005-30% (in composition total weight) especially.

The example of polysaccharide comprises xanthan gum, cationic cellulose, hyaluronate sodium, chitin alginate esters (salt), chitosan, carboxymethyl cellulose, methylhydroxypropylcellulose, ι-carrageenan, lambda-carrageenan, pullulan, Auricularia, ghatti gum, trehalose and agar.

When allocating these polysaccharides into, they can be single ground or the composite by any way compositions that is used for, its allocation ratio be preferred with 0.0001-20%, especially is 0.001-10% (in composition total weight).

Amino acid whose example comprises natural amino acid, as glycine, serine, cystine, alanine, threonine, cysteine, valine, phenylalanine, methionine, leucine, tyrosine, proline, isoleucine, tryptophan and hydroxyproline; Acidic amino acid is as aspartic acid, asparagine, glutamine and glutamic acid; Basic amino acid is as arginine, histidine and lysine; In addition, also have betanin and amino acid derivativges, acyl group sarcosine and its esters, acyl glutamic acid and its esters, acyl group-Beta-alanine and salt thereof, glutathion, 2-pyrrolidone-5-carboxylic acid and salt thereof; And oligopeptide, as glutathion, carnosine, Gramicidin S, Tysocidine A and Tyrocidine B, and guanidine derivatives and the salt thereof described in the Japanese Unexamined Patent Publication No 228023/1994.

When allocating these aminoacid into, they can singlely or composite by any way be used for compositions.Its allocation ratio 0.001-50% is preferred, especially is 0.001-30% (in composition total weight).

The example of film former comprises polyvinyl, as polyvinyl alcohol, polyvinylpyrrolidone, sodium polyacrylate; Emulsion is as chitosan pullulan emulsion and alkyl acrylate copolymer emulsion; Polypeptide is as soluble collagen, elastin hydrolysis and silk extract; And molecular weight is 20,000-4,000,000 Polyethylene Glycol.

When allocating these film former into, their allocation ratio 0.001-10% is preferred, especially is 0.001-5% (in composition total weight).

The example of antiinflammatory comprises glycyrrhizic acid and salt, glycyrrhetinic acid and salt thereof, episilon amino caproic acid and salt thereof, allantoin, lisozima, S-guaiazulene, methyl salicylate, gamma oryzanol and bisabolol.Wherein, glycyrrhetinic acid, glycyrrhetinic acid stearate and episilon amino caproic acid are preferred.

When allocating these antiinflammatory into, they can singlely or composite by any way be used for compositions.Its allocation ratio is preferred with 0.001-5%, especially is 0.01-2% (in composition total weight).

The example of creating singlet oxygen by using scavenger or antioxidant comprises carotenoid, as alpha-carotene, beta-carotene, gamma carotene, lycopene, kryptoxanthin, phylloxanthin, cryptoxanthin, different cryptoxanthin, rhodoxanthin, capsanthin and crocetin; 1,4-diazacyclo octane, 2,5-dimethyl furan, 2-methylfuran, 2,5-diphenyl furan, 1,3-diphenyl isobenzofuran, alpha-tocopherol, betatocopherol, Gamma-Tocopherol, d-tocopherol, histidine, tryptophan, methionine, L-cystine, L-cysteine and alanine or their Arrcostab; Tannin is as dibenzylatiooluene, butylated hydroxyanisole (BHA), ascorbic acid, tannic acid, epicatechin, table meat catechin (epicarocatechin), epicatechin gallate ECG and table meat catechin gallic acid ester; Flavonoid is as rutin; Enzyme is as superoxide dismutase, catalase, glutathione peroxidase and glutathion reductase; And Ennds, Peralchin, platonin, capsaicin and scutellariae,radix extract.

Wherein, carotene, tocopherol, ascorbic acid, tannic acid, epicatechin gallate ECG and table meat catechin gallic acid ester are preferred.

When allocating these creating singlet oxygen by using scavengers or antioxidant into, they can be single or be used for compositions in any composite mode.Its allocation ratio is preferred with 0.001-5%, especially is 0.01-2% (in composition total weight).

Have no particular limits being used for pH regulator agent of the present invention, but the example comprises metal hydroxides, as sodium hydroxide, potassium hydroxide and Lithium hydrate, triethanolamine, isopropanolamine, diisopropanolamine (DIPA), carbamide, episilon amino caproic acid, pyrrolidone sodium carboxylate, sodium dihydrogen phosphate, sodium hydrogen phosphate, sodium citrate, organic acid such as citric acid, lactic acid, succinic acid and tartaric acid, and betanin such as glycinebetaine and lysine betanin.

Preferably adjust between the 2-11 according to the pH value of cosmetic composition of the present invention, especially between the 3-10.

The example of other composition that can mention is an inorganic salts, as magnesium sulfate, potassium sulfate, magnesium chloride and sodium chloride; Viscosity modifier is as polyvinyl alcohol, carboxy vinyl polymer, gelatin, Tragacanth, pectin, mannan, carob gum, galactan, Radix Acaciae senegalis, xanthan gum, glucosan, succinic acid glucosan, curdlan, Fructus cydoniae oblongae seed, soageena, casein, albumin, sodium polyacrylate, polyvinylpyrrolidone, poly-(vinyl methyl ether), hydroxyethyl-cellulose, ethyl cellulose, hydroxypropyl cellulose, starch, carboxymethyl starch, methyl starch, agarose, propylene glycol alginate, sodium alginate and guar gum; Be commonly referred to as the hydrophilic hygroscopic matter of nature moisturizing factor (NMF), or their derivant; Antiseptic is as hydroxybenzoate, dehydroactic acid and salt thereof; Chelating agen is as ethylenediaminetetraacetic acid and salt and Metaphosphoric acid and salt thereof; The beauty treatment composition is as arbutin, kojic acid and intacellin; Cell activator is as collagen protein, psicosaponin, royal jelly, hyclone extract, cattle spleen extract, Bovine Placenta extract, epicholestanol, ribonucleic acid; Also have UV absorbent, carbamide, coloring material, various vitamin, sebum secretion inhibitor, sebum secretion promoter, active ingredient and fragrant base in addition.

Hereinafter will the present invention will be described in more detail by embodiment.But, the invention is not restricted to these embodiment.

The preparation method of preparation embodiment 1:(Radix Agrimoniae extracting solution)

1000 milliliters of 50v/v% ethanol are added in the exsiccant Radix Agrimoniae herb triturate of 100 grams, at room temperature extracted 3 days, stirred in good time.Filtration obtains extracting solution, and filtrate was left standstill 3 days at 5 ℃, and then filters, and obtains the supernatant.

The solids content of the Radix Agrimoniae extracting solution that obtains is 1.2%.

The preparation method of preparation embodiment 2:(Japan Catalpa ovata Don. extracting solution)

Except that the triturate with exsiccant Japanese Catalpa ovata Don. fruit replaced exsiccant Radix Agrimoniae triturate, all the other prepared Japanese Catalpa ovata Don. extracting solution by the method identical with preparing embodiment 1.

The dried solids content of the Japanese Catalpa ovata Don. extracting solution that obtains is 1.1%.

The preparation method of preparation embodiment 3:(hiba arborvitae extracting solution)

Replace outside the exsiccant Radix Agrimoniae triturate divided by the leaf of hiba arborvitae, the drying ground of Pi Hegen, prepare the hiba arborvitae extracting solution by the method identical with preparing embodiment 1.

The dried solids content of the hiba arborvitae extracting solution that obtains is 1.0%.

The preparation method of preparation embodiment 4:(HORUTOSO extracting solution)

Triturate divided by exsiccant HORUTOSO seed or Herb replaces outside the exsiccant Radix Agrimoniae triturate, and all the other use the method identical with preparing embodiment 1 to prepare the HORUTOSO extracting solution.The dry solids content of the HORUTOSO extracting solution that makes is 1.2%.

The preparation method of the white pubescence Herba Rabdosiae glaucocalycis of preparation embodiment 5:(extracting solution)

Exsiccant triturate divided by the white pubescence Herba Rabdosiae glaucocalycis of Herb replaces outside the exsiccant Radix Agrimoniae triturate, and all the other prepare white pubescence Herba Rabdosiae glaucocalycis extracting solution by the method identical with preparing embodiment 1.

The dry solids content of the white pubescence Herba Rabdosiae glaucocalycis extracting solution that makes is 1.0%.

The preparation method of preparation embodiment 6:(KIJITSU extracting solution)

Replace outside the exsiccant Radix Agrimoniae triturate divided by exsiccant KIJITSU triturate, all the other prepare the KIJITSU extracting solution by the method identical with preparing embodiment 1.

The dry solids content of the KIJITSU extracting solution that makes is 1.0%.

Embodiment 1:

Preparation contains the oil/water type cream of following component, in order to estimate by continuous use improving pachylosis degree and wrinkle resistant effect.Evaluation result is listed in table 2.Incidentally, allocate the kind of plant extraction liquid in the emulsifiable paste and amine derivative and consumption into and the consumption of the acid polysaccharide allocated into is listed in the table 1.

(component) (%)

(1) plant extraction liquid (seeing Table 1) sees Table 1

(2) acid polysaccharide sees Table 1

(3) amine derivative (seeing Table 1) sees Table 1

(4) citric acid 1.0

(5) polyoxyethylene (10) hardened castor oil 1.0

(6) sorbitol monostearate 0.5

(7) SMT 0.5

(8) polyoxyethylene (4) lauryl ether 0.5

Sodium phosphate

(9) cholesterol 1.3

(10) cetearyl alcohol (cetostearyl alcohol) 2.0

(11) the cholesterol isostearate 1.0

(12) squalane 2.0

(13) the neopentyl glycol dicaprate 8.0

(14) methyl polysiloxane ^{* 2}4.0

(15) cyclopolysiloxane ^{* 3}4.0

(16) antiseptic is an amount of

(17) pure water surplus

(18) ethanol 3.0

(19) aromatic is an amount of

Amount to 100.0

^*1: the acid polysaccharide that the Polianthes tuberosa L. callus for preparing according to embodiment in the Japanese Unexamined Patent Publication No 1,099,7/1,989 1 obtains.

^*2: polysiloxanes KF96A (6 centistoke) is the product of Shin-Etsu chemistry company limited.

^*3: the mixture of polysiloxanes SH-244, SH-245 or SH-244 and SH-245 3: 2 (weight) is the product of Dow Corning Toray Silicone company limited.

Table 1

		Plant extract	Acid polysaccharide	Amine derivative
					Product of the present invention	??1	Radix Agrimoniae extracting solution (preparation embodiment 1) 1.0%	????1.0％	???????-
??2	Japan's Catalpa ovata Don. extracting solution (preparation embodiment 2) 1.0%	?????-	In the formula (1), R 1=iso stearyl (Emery type) R 2＝CH 2CH 2OH， ?R 3＝R 4′＝R 5＝R 6＝H.X＝-O- ?????0.1％
				??3		Hiba arborvitae extracting solution (preparation embodiment 3) 1.0%	????1.0％	???????-
??4	HORUTOSO extracting solution (preparation embodiment 4) 1.0%	?????-	In the formula (1), R 1=12-hydroxyl stearyl, R 2＝CH 2CH 2OH，R 3-＝R 4＝ R 5＝R 6＝H，X＝-O- ?????0.1％
				??5		White pubescence Herba Rabdosiae glaucocalycis extracting solution (preparation embodiment 5) 1.0%	?????-	In the formula (1), R 1=iso stearyl (Emery type) R 2＝CH 2CH 2OH， R 3＝R 4′＝R 5＝R 6＝H，X＝-O- ????0.05％
??6	KIJITSU extracting solution (preparation embodiment 6) 1.0%	????0.05％	In the formula (1), R 1=12-hydroxyl stearyl R 2＝CH 2CH 2OH，R 3-＝R 4＝ R 5＝R 6＝H，X＝-O- ????0.05％
				??7		Hiba arborvitae extracting solution (preparation embodiment 3) 1.0%	????0.05％	In the formula (1), R 1=iso stearyl (Emery type) R 2＝CH 2CH 2OH ???R 3＝R 4′＝R 5＝R 6＝H，X＝-O- ????0.1％
Control product	??1	White pubescence Herba Rabdosiae glaucocalycis extracting solution (preparation embodiment 5) 1.0%	?????-						????????-
				??2	????????-	????1.0％	????????-
	??3	????????-	?????-					In the formula (1), R 1=iso stearyl (Emery type) R 2＝CH 2CH 2OH. R 3＝R 4′＝R 5＝R 6＝H，X＝-O- ????0.1％
				??4	????????-	?????-	????????-

(preparation method)

Oil phase component ((3), (5), (6) and (8)-(14)) is heated to 80 ℃ makes their fusings.Be added in the above-mentioned fused oil phase component by stirring the water component ((1), (2), (4), (7), (16) and (17)) that will be heated to 80 ℃, make its emulsifying.Under agitation make the emulsion that makes be cooled to 50 ℃.Then, add component (15), (17) and (18), and continue stirring and make the mixture that obtains further be cooled to room temperature, obtain oil/water type cream thus to emulsion

(evaluation methodology)

(I) improve the effect of pachylosis:

The women who selects 10 20-50 year, cheeks pachylosis in winter is as the volunteer, and the left cheek and the right cheek that different external skin-care compositions are put on each special hope person respectively continued for two weeks.Finished second day that smears test two weeks, and carried out the test of following items.

(1) skin conductivity

With 37 ℃ of warm water flush awaies on the face after the compositions, allow each volunteer in the air conditioning chamber of 20 ℃ and 40% humidity, have a rest 20 minutes, measure the cuticular water content of face with skin conductivity instrument (making) by IBS company.The electric conductivity value little expression skin of healing is more coarse.Electric conductivity value be 5 or littler expression skin seriously coarse.Otherwise electric conductivity value is 20 or shows that greater than 20 skin is not coarse substantially.The gained result of the test is represented with meansigma methods.

(2) pachylosis degree marking:

According to following standard with perusal pachylosis degree and evaluate classification.Each scoring is represented with meansigma methods.

0: do not observe pachylosis;

1: it is coarse slightly to observe skin;

2: observe pachylosis;

3: it is more serious to observe pachylosis;

4: it is seriously coarse to observe skin.

(II): wrinkle resistant effect:

External skin-care composition (80 microlitre) is applied on the nothing hair mouse.

After two hours,, smear with per sample (p.s.) immediately after the irradiation with ultraviolet (UV)-B (1MED or lower) irradiation mouse.This process is carried out weekly 5 times, carries out for 16 weeks altogether.Irradiation energy is measured with ultraviolet radiation meter (UV-R-305/365 days, the product of Tokyo Optical Co., Ltd).Energy be 0.28 milliwatt/centimetre ²The time accumulated dose measured be 100 millis burnt/centimetre ², so that the dosage of each irradiation is 1MED or is less than 1MED.

Finish smearing in 16 weeks/exposure experiment after, form the degree of wrinkle and evaluate sample with visualization according to following standard (wrinkling index).Represent with 10 result of the test meansigma methodss of not having the hair mouse.

Standard (wrinkling index):

1: do not produce wrinkle;

2: produce few wrinkle;

3: produce a little wrinkle;

4: seriously produce wrinkle.

(result)

Table 2

	Product of the present invention
								????1	????2	????3	????4	????5	????6	????7
	The skin conductivity pachylosis degree wrinkling index of giving a mark	??47 ??0.2 ??0.8	??4?5 ??0.3 ??0.9	??4?8 ??0.3 ??0.8	??4?7 ??0.2 ??0.8	??4?9 ??0.3 ??0.9	??4?6 ??0.3 ??0.8								??5?0 ??0.2 ??0.7

Table 2 (contrast)

	Control product
					????1	????2	????3	????4
	The skin conductivity pachylosis degree wrinkling index of giving a mark	??2?1 ??1.1 ??2.3	??2?0 ??1.0 ??2.8	??2?0 ??1.2 ??2.2					??15 ??2.1 ??3.5

Listed result can obviously find out from table 2, and all compositionss according to the present invention have excellent effect to the roughening of improving skin and the generation that prevents wrinkle.

Embodiment 2:(water/oil type emulsifiable paste)

Preparation contains the water/oil type emulsifiable paste of following component.

(component) (%)

(1) amine derivative ^{* 4}3.5

(2) citric acid 0.5

(3) glycerol 1.0

(4) cholesterol 0.5

(5) the cholesterol isostearate 0.5

(6) polyether-modified polysiloxanes ^{* 5}2.0

(7) cyclopolysiloxane ^{* 6}20.0

(8) methyl phenyl silicone ^{* 7}5.0

(9) magnesium sulfate 0.5

(10) acid polysaccharide (be used in embodiment 1 in identical) 5.0

(11) the hiba arborvitae extract 5.0

(by preparation embodiment 3 preparations)

(12) pure water surplus

(13) antiseptic is an amount of

(1 4) aromatic is an amount of

Amount to 100.0

^*4: with the chemical compound of general formula (1) expression, wherein R ¹Be isooctadecane base (Emery type), R ²Be CH ₂CH ₂OH, R ³, R ⁴, R ⁵And R ⁶Be that hydrogen and X are-O

^*5: polysiloxanes KF-6015 is the product of Shin-Etsu chemicals company limited

^*6: the mixture of polysiloxanes SH-244 and SH-245 3: 2 (weight), the product of Dow Corning Toray Silicone company limited

^*7: polysiloxanes SP-557, the product of Dow Corning Toray Silicone company limited.

(preparation method)

Oil phase component ((1), (4)-(6) and (8)) is heated to 80 ℃ makes their fusions, be added in the above-mentioned fused oil phase component, make their emulsifying by stirring the water component ((2), (3), (9)-(13)) that will be heated to 80 ℃.Along with making the emulsion of gained, stirring is cooled to 50 ℃.Then, add component (7) and (14) to emulsion and also continue to stir to make the mixture that obtains further be cooled to room temperature, obtain water/oil type cold cream thus.

Embodiment 3:(oil/water type washing liquid of preserving moisture)

Oil/water the type that contains following component according to the means known in the art preparations washing liquid of preserving moisture.

(component) (%)

(1) amine derivative (with used identical among the embodiment 2) 3.0

(2) cholesterol 0.5

(3) 2-(2-hydroxyl-oxethyl) ethyl guanidine ^{* 8}0.5

(4) spermol 1.0

(5) vaseline 2.0

(6) angle alkane shark 5.0

(7) dimethyl polysiloxane (6 centistoke) 2.0

(8) glycerol 4.0

(9) 1, ammediol 2.0

(10) polyoxyethylene (20) Arlacel-80 0.5

(11) Arlacel-60 0.3

(12) acid polysaccharide (with used identical among the embodiment 1) 5.0

(13) cholesterol list-n-hexadecyl succinate 1.0

(14) octadecyl glycyrrhetin acid esters 1.0

(15) tocopherol 1.0

(16) succinic acid 0.55

(17) sodium dihydrogen phosphate 0.9

(18) carboxy vinyl polymer ^{* 9}0.15

(19) potassium hydroxide 0.045

(20) KIJITSU extracting solution (by preparation embodiment 3 preparations)

(21) pure water surplus

Amount to 100.0

^*8: according to embodiment 1 preparation of Japanese Unexamined Patent Publication No 170628/1995.

^*9:Carbopol 941, the product of Goodrich Corporation.

Embodiment 4 (essential oil of preserving moisture)

The essential oil of preserving moisture that contains following component according to the means known in the art preparation.

(component) (%)

(1) acid polysaccharide (with used identical among the embodiment 1) 0.20

(2) xanthan gum 0.50

(3) ethanol 6.40

(4) amine derivative (with being used for the identical of embodiment 2) 0.10

(5) 2-(2-hydroxyl-oxethyl) ethyl guanidine 0.10

(with being used for the identical of embodiment 5)

(6) carbamide 2.50

(7) episilon amino caproic acid 0.83

(8) succinic acid 1.50

(9) glycerol 12.00

(10) dipropylene glycol 3.00

(11) right-methyl butex 0.20

(12) the different cetyl ether of polyoxyethylene (20E.O.) 0.30

(13) tannic acid 0.02

(14) white pubescence Herba Rabdosiae glaucocalycis extracting solution 0.10

(by preparation embodiment 5 preparations)

(16) antiseptic 0.10

(17) pure water surplus

Amount to 100.0

Each external skin-care composition that makes among the embodiment 2-4 is preventing the corium aging, as improves pachylosis and wrinkle resistant and unfold the wrinkle of skin aspect and have excellent effect.

Claims (5)

1. contain following component (A) and external skin-care composition (B):

(A) plant extract; And

(B) one or more are selected from by the derive sour heteropolysaccharide (b-1) that obtains and with the combination of the amine derivative (b-2) of general formula (1) expression of the callus of Polianthes tuberosa L. platymiscium:

R in the formula ¹Be straight chain, side chain or the cyclic hydrocarbon group that contains 1-40 carbon atom, it can be replaced by at least one hydroxyl, or contains 1-5 carbon atom and heteroatomic alkyl; R ², R ³, R ⁴, R ⁵And R ⁶Be identical or differ from one another independently of one another for hydrogen atom or for containing the hydrocarbyl group of 1-20 carbon atom, can be replaced by at least one hydroxyl, X is-O-or-CO-O-, but be incorporated into R with carbonyl bond ¹Be condition, or formula (1) and the sour salt that forms.

2. according to the external skin-care composition of claim 1, wherein component (A) is at least a plant extract that is selected from Radix Agrimoniae, Japanese Catalpa ovata Don., hiba arborvitae, the white pubescence Herba Rabdosiae glaucocalycis of HORUTOSO and KIJITSU.

3. according to the external skin-care composition of claim 1 or 2, wherein the sour heteropolysaccharide (b-1) of B component be from the callus of Polianthes tuberosa L. derive and sour heteropolysaccharide.

4. according to each external skin-care composition among the claim 1-3, the ratio that said composition contains component (A) and component (B) is respectively 0.0001-20% (weight) and 0.0001-20% (weight) in the drying solid amount.

5. according to each external skin-care composition among the claim 1-4, the component of said composition (B) contains by the callus that belongs to the Polianthes tuberosa L. plant derives and sour heteropolysaccharide (b-1) that gets and amine derivative (b-2) or formula (1) component of representing with general formula (1) and the sour salt that forms.