CN1679581A - Composition of an external dermatological agent and fibers with effect of promoting lipid decomposition - Google Patents
Composition of an external dermatological agent and fibers with effect of promoting lipid decomposition Download PDFInfo
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- CN1679581A CN1679581A CN 200510008504 CN200510008504A CN1679581A CN 1679581 A CN1679581 A CN 1679581A CN 200510008504 CN200510008504 CN 200510008504 CN 200510008504 A CN200510008504 A CN 200510008504A CN 1679581 A CN1679581 A CN 1679581A
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Abstract
Provided is a skin care preparation for external use and a fiber each containing a xanthine derivative and increased in its percutaneous absorbability. The skin care preparation and the fiber are obtained each by compounding the xanthine derivative and one or two or more component selected from the group consisting of isostearyl alcohol, diisopropyl sebacate and an alkylene polyglycol dineopentanoate.
Description
Technical field
The present invention relates to be used to promote the skin preparations for extenal use and the fiber of lipid decomposition.
Background technology
For the unnecessary fat that reduces face and health etc., the body that keeps oneself slim, known outside various motions, dietary restrictions etc., the skin preparations for extenal use of the gel of use promotion body intracellular metabolic, frost etc.In such skin preparations for extenal use, well known fact is, the xanthine derivative that is combined with caffeine etc. decomposes as the lipid of the adipose cell that promotes to constitute fat and brings the material of weight reducing effect.In addition, also carried out caffeine is fixed on the fiber, made fiber have the test (patent documentation 1) of weight reducing function.But though the xanthine derivative of caffeine etc. has the steatolysis facilitation of height, but still existence can not be given full play to the problem of effect because its percutaneous absorbs low.For example, outside xanthine derivative, cooperate plant extract or other composition, raising steatolysis facilitation effect etc. again, carried out various tests (for example patent documentation 2 and 3) with steatolysis facilitation.But these tests all are further to add other material with lipid decomposition facilitation to improve the scheme that lipid decomposes facilitation effect, and the percutaneous that can not improve xanthine derivative absorbs.Therefore, in skin preparations for extenal use that contains xanthine derivative or fiber, strong percutaneous absorption of wishing to improve xanthine derivative.
[patent documentation 1] spy opens the 2000-212873 communique
[patent documentation 2] spy opens flat 11-246458 communique
[patent documentation 3] spy opens flat 10-101546 communique
Summary of the invention
In view of the foregoing, the objective of the invention is to, in skin preparations for extenal use that contains xanthine derivative or fiber, the percutaneous that improves xanthine derivative absorbs, and provides to have skin preparations for extenal use and the fiber that higher lipid decomposes facilitation effect.
The inventor is by cooperating a kind of being selected from the group that isooctadecanol, Dermol DIPS, two neopentanoic acid poly alkylene glycol esters form or 2 kinds or the oiliness composition more than it with xanthine derivative, the percutaneous that discovery can improve xanthine derivative significantly absorbs, thereby has finished the present invention.
The invention provides contain xanthine derivative and be selected from isooctadecanol, Dermol DIPS and group that two neopentanoic acid poly alkylene glycol esters are formed in a kind or the skin preparations for extenal use of 2 kinds or its above oiliness composition.By these oiliness compositions are cooperated simultaneously with xanthine derivative, can be when skin preparations for extenal use be used in skin, the percutaneous that significantly improves xanthine derivative absorbs.
Skin preparations for extenal use of the present invention preferably promotes the skin preparations for extenal use that lipid decomposes, and for example is the weight reducing skin preparations for extenal use.
The present invention also provide contain xanthine derivative and be selected from isooctadecanol, Dermol DIPS and group that two neopentanoic acid poly alkylene glycol esters are formed in a kind or the fiber of 2 kinds or its above oiliness composition.Contain these oiliness composition and xanthine derivatives in the fiber simultaneously by making, can significantly improve percutaneous absorption by the xanthine derivative of fiber.
Particularly when having cooperated isooctadecanol, absorb because can further improve the percutaneous of xanthine derivative, so skin preparations for extenal use of the present invention or fiber preferably contain isooctadecanol.
In addition, because the lipid of caffeine decomposes the facilitation effect excellence, so preferably use caffeine as xanthine derivative.
Skin preparations for extenal use of the present invention and fiber, because contain xanthine derivative simultaneously and be selected from isooctadecanol, Dermol DIPS and group that two neopentanoic acid poly alkylene glycol esters are formed in a kind or 2 kinds or its above oiliness composition, when being used for skin, bring the percutaneous of higher xanthine derivative to absorb, the lipid decomposition facilitation that xanthine derivative produces can be improved, thereby bigger weight reducing effect can be brought.
The specific embodiment
As the xanthine derivative that uses in the present invention, can enumerate for example caffeine, theobromine sodium formate, theobromine, xanthine, aminophylline, Oxtriphylline, diprophylline, brontyl, Oxtriphylline etc. or their salt.Among the present invention, can a kind individually or make up 2 kinds or its above these xanthine derivatives that use.Particularly because the lipid of caffeine decomposes the facilitation effect excellence, so the preferred caffeine that uses among the present invention.These xanthine derivatives both can be also can be synthetic material from crude, can use the commercial goods in the present invention.
The use level of the xanthine derivative in the skin preparations for extenal use of the present invention, can be not particularly limited according to suitably decisions such as the forms of skin preparations for extenal use, but with respect to the quality of skin preparations for extenal use, preferably 0.0001 quality % or more than it is more preferably 0.005～5.0 quality %.
In addition, to the addition of the xanthine derivative in the fiber of the present invention, can be according to suitably decision such as the kind of fiber and application target, be not particularly limited, but with respect to the quality of processing fiber, preferably 0.001～10 quality % is more preferably 0.005～5.0 quality %.
Isooctadecanol is to move the oiliness composition that promotes that composition is used, the commercial goods that for example can use Risonol-18SP, isooctadecanol EX etc. in the present invention as the sebum that the flowability of liquid make-up or emulsion is adjusted in agent or plasticizer or the scalp and hair-care composition.
Dermol DIPS is used as the oiliness composition with lubricant effect or moistening effect in Hair grooming is made up material or frost etc., for example can use the commercial goods of NIKKOL DIS (daylight ケ ミ カ Le ズ system) or マ Star ト Le one プ (becoming and the system of changing into) etc. in the present invention.
The two neopentanoic acid poly alkylene glycol esters that use among the present invention are the international chemical compounds represented with following general formula (1) put down in writing in No. 03/026698 pamphlet that disclose:
(in the general formula, m represents 2～4 integer, and n represents 2～3 integer)
Concrete can enumerate two neopentanoic acid tripropylene glycol esters, two neopentanoic acid dipropylene glycol esters, two neopentanoic acid tetraethylene glycol (TEG) esters, two neopentanoic acid triethyleneglycol ester, two neopentanoic acid diethylene glycol esters etc.Among the present invention, special because two neopentanoic acid tripropylene glycol esters have salubrious usability, little, the excellent in safety of skin irritation, so among the present invention, preferably use two neopentanoic acid tripropylene glycol esters.
Above-mentioned oiliness composition can use independent a kind or make up that 2 kinds or its are above to be used in the present invention.
The use level of the above-mentioned oiliness composition in the skin preparations for extenal use of the present invention, can be according to the suitably decisions such as form of skin preparations for extenal use, have no particular limits, but with respect to the quality of skin preparations for extenal use, be preferably 0.001～50 quality %, be more preferably the scope of 0.005～20 quality %.
In addition, the addition of the above-mentioned oiliness composition in fiber of the present invention can be according to suitably decision such as the kind of fiber or application target, have no particular limits, but with respect to the quality of processing fiber, be preferably 0.001～10 quality %, more preferably 0.005～5 quality %.
In this manual, " skin preparations for extenal use " comprises cosmetics, pharmaceuticals, cosmeceutical (medicine part outer article) etc.In addition, its dosage form also comprises 3 layers of aqueous solution classes, solubilized class, emulsifying class, fluid class, gel-like, paste class, ointments, aerosol class, water-2 layers of class of oil, water-oil-powder etc., comprises dosage form arbitrarily.In addition, be also contained in the type of carrying on the lamellar base.
Skin preparations for extenal use of the present invention, except that above-mentioned must constituent, as required, can suitably cooperate employed other any composition in the skin preparations for extenal use of common cosmetics or medicine etc., can be according to the purpose dosage form by the conventional method manufacturing.For example, can cooperate above-mentioned must gradation composition and a kind of following compositions or 2 kinds or more than it, prepare skin preparations for extenal use of the present invention.
As UV absorbent; for example can enumerate; para-amino benzoic acid (the following PABA that slightly is called); the PABA monoglyceride; N; N-dipropoxy PABA ethyl ester; N; N diethoxy PABA ethyl ester; N; N-dimethyl PABA ethyl ester; N; N-dimethyl PABA butyl ester; N; the benzoic acids UV absorbent of N-dimethyl PABA methyl ester etc.; the anthranilic acid UV absorbent of the high ester of N-acetyl group ortho-aminobenzoic acid etc.; amyl salicylate; salicylic acid ester; the high ester of salicylic acid; ethylhexyl salicylate; phenyl salicytate; benzyl salicylate; the salicylic acid UV absorbent of right-isopropyl alcohol phenyl salicylic acid esters etc.; the cinnamic acid monooctyl ester; Ethyl 4-isopropylcinnamate.; methyl-2; 5-diisopropyl cinnamate; ethyl-2; 4-diisopropyl cinnamate; methyl-2; 4-diisopropyl cinnamate; propyl group-right-Methoxycinnamate; isopropyl-right-Methoxycinnamate; isopentyl-right-Methoxycinnamate; octyl group-right-Methoxycinnamate (2-ethylhexyl-right-Methoxycinnamate); 2-ethoxyethyl group-right-Methoxycinnamate; cyclohexyl-right-Methoxycinnamate; ethyl-alpha-cyano-beta-phenyl cinnamate; 2-ethylhexyl-alpha-cyano-beta-phenyl cinnamate; glyceryl list-2-ethyl hexanoyl base-di-p-methoxy cinnamate; the cinnamic acid UV absorbent of two (trimethicone) silicyl isopentyl esters of trimethoxy meat silicic acid methyl etc.; 3-(4 '-methyl benzal)-d; the l-camphane; 3-benzal-d; the l-camphane; urocanic acid; the urocanic acid ethyl ester; 2-phenyl-5-Jia base benzoxazole; 2; 2 '-hydroxy-5-methyl base phenyl benzotriazole; 2-(2 '-hydroxyl-5 '-t-octyl phenyl) benzotriazole; 2-(2 '-hydroxyl-5 '-aminomethyl phenyl) benzotriazole; dibenzylidene azine (ジ ベ Application ザ ラ ジ Application); anisil methane; 4-methoxyl group-4 '-tert-butyl group dibenzoyl methane; 5-(3; the inferior norborneol alkyl of 3-dimethyl-2-)-3-pentane-2-ketone; dimorpholino tetrahydro pyridazine ketone etc. can use arbitrarily a kind or 2 kinds or more than it.
As the ultraviolet dispersant, can enumerate the powder of titanium oxide, particulate titanium dioxide, zinc oxide, particulate oxide zinc, ferrum oxide, particulate oxide ferrum, cerium oxide etc.
These ultraviolet dispersants can use needle-like, spindle shape, spherical, granulous powder usually.In addition, preferable particle size is 0.1 μ m or its following fine-particle powder.
Also preferably handle by the polysiloxanes of hydrogenated methyl alkadienes polysiloxanes or silane coupling agent etc.; Metallic soap is handled; The ultraviolet dispersant that the fluorine processing of perfluoroalkyl di(2-ethylhexyl)phosphate ethanolamine salt or perfluoroalkyl silane etc., dextrin fatty acid ester processing etc., hydrophobization are handled.
As liquid fat, can enumerate for example American Avocado Tree oil, Camellia oil, Oleum Testudinis, macadimia nut oil, Semen Maydis oil, ermine oil, olive oil, Oleum Brassicae campestris, egg oil, Oleum sesami, almond oil, Semen Tritici aestivi germ oil, Flos Camelliae Japonicae caul-fat, Oleum Ricini, Semen Lini oil, safflower oil, Oleum Gossypii semen, perilla oil, soybean oil, Oleum Arachidis hypogaeae semen, Oleum Camelliae, Chinese torreya oil, Testa oryzae oil, Paulownia oil, Japanese tung oil, Jojoba oil, germ oil, two triglycerols etc.
Solid grease can be enumerated for example cocoa butter, cocos nucifera oil, and horse fat, the sclerosis cocos nucifera oil, Petiolus Trachycarpi oil, Adeps Bovis seu Bubali, Adeps caprae seu ovis, the sclerosis Adeps Bovis seu Bubali, palm kernel oil, Adeps Sus domestica, Os Bovis seu Bubali fat, the haze tallow kernel oil, fixed oil, cattle foot fat, haze tallow, hardened castor oil, etc.
As the wax class, can enumerate for example Cera Flava, candelilla wax, cotton wax, Brazil wax, Fructus Lauri nobilis wax, insect wax, spermaceti, montan wax, bran wax, lanoline, kapok wax, the acetic acid lanoline, liquid lanolin, Caulis Sacchari sinensis fat, lanolin fatty acid isopropyl ester, lauric acid hexyl ester, reduction lanoline, Jojoba wax, the hard lanoline, shellac wax, POE lanoline alcohol ether, POE lanolin alcohol acetas, POE cholesterol ether, lanolin fatty acid macrogol ester, POE hydrogenation lanoline alcohol ether etc.
As hydrocarbon ils, can enumerate for example fluid paraffin wax, ceresine, squalane, pristane, paraffin, ceresin, Squalene, vaseline, Tissuemat E, Fischer-Tuo synthetic wax etc.
As higher fatty acids, can enumerate for example lauric acid, myristic acid, Palmic acid, stearic acid, behenic acid, oleic acid, 9-undecylenic acid, the acid of appropriate that, linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), docosahexenoic acid (DHA) etc.
As higher alcohol, can enumerate for example straight chain alcohol (for example lauryl alcohol, spermol alcohol, octadecane alcohol, docosane alcohol, myristyl alcohol, oleyl alcohol, 16/octadecanol etc.); Branched-chain alcoho (for example, single batiolum (batilol), 2-decyl tetradecanol, lanolin alcohol, cholesterol, plant sterol, hexyl dodecanol, octyldodecanol etc.) etc.
As synthetic ester oil, can enumerate for example tetradecane isopropyl propionate; sad cetyl ester; tetradecanoic acid octyl group Lauryl Ester; the hexadecane isopropyl propionate; the octadecane acid butyl ester; the own ester of dodecanoic acid; tetradecanoic acid myristyl ester; decyl oleate; the sad hexyl of dimethyl ester in the last of the ten Heavenly stems; the lactic acid cetyl ester; lactic acid myristyl ester; the acetic acid wool grease; octadecanoic acid isocetyl ester; isooctadecane acid isocetyl ester; 12-hydroxyl octadecanoic acid cholesterol ester; two-2 ethyl hexanoic acid glycol ester; the dipentaerythritol fatty acid ester; single isooctadecane acid N-alkyl diol ester; two capric acid DOPCP; malic acid two isooctadecane base esters; two-2-heptyl hendecane acid glyceride; three-2 ethyl hexanoic acid trimethylolpropane; three isooctadecanes acid trimethylolpropane; four-2 ethyl hexanoic acid, five pentaerythritol esters; three-2 ethyl hexanoic acid glyceride; tricaprylin; three different hexadecane acid glycerides; three isooctadecanes acid trimethylolpropane; cetyl-2-ethylhexanoate; 2-ethylhexyl hexadecane acid esters; three-tetradecane acid glyceride; three-2-heptyl hendecane acid glyceride; the Castor Oil Fatty Acid methyl ester; oleic acid oil base ester; aceto-glyceride; hexadecanoic acid 2-heptyl undecyl ester; diisobutyl adipate; N-lauroyl-L-glutamic acid-2-octyl group dodecyl ester; adipic acid two-2-heptyl undecyl ester; the ethyl laurate; Diisooctyl Sebacate; tetradecanoic acid 2-hexyl ester in the last of the ten Heavenly stems; hexadecanoic acid 2-hexyl ester in the last of the ten Heavenly stems; adipic acid 2-hexyl ester in the last of the ten Heavenly stems; succinic acid 2-Octyl Nitrite; triethyl citrate; poly(ethylene oxide) poly(propylene oxide) random copolymer methyl ether etc.
As silicone oil, can enumerate for example chain polysiloxanes (for example dimethyl polysiloxane, methyl phenyl silicone, diphenyl polysiloxanes etc.); Organic siliconresin, silicone rubber, the various modified polyorganosiloxane (amino modified polysiloxane, polyether-modified polysiloxanes, alkyl-modified polysiloxanes, fluorine modified polyorganosiloxane etc.) of cyclic polysiloxanes (for example octamethylcy-clotetrasiloxane, decamethylcyclopentaandoxane, ten diformazan basic rings, six siloxanes etc.), formation space network.
Other, can enumerate for example wetting agent of Polyethylene Glycol, glycerol, 1,3 butylene glycol, erithritol, Sorbitol, xylitol, maltol etc.; Cellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, methylhydroxypropylcellulose, methylcellulose, carboxymethyl cellulose Cydonia oblonga seed, carrageenin, pectin, mannan, heat is coagulated polysaccharide, chondroitin sulfate, starch, galactan, dermatan sulfate, glycogen, Radix Acaciae senegalis, Heparan sulfate, hyaluronic acid, hyaluronate sodium, Tragacanth, keratan sulfate, chrondroitin, HANSHENGJIAO, mucoitinsulfuric acid, the ethoxy guar gum, the carboxymethyl guar gum, guar gum, glucosan, cutin sulphuric acid, locust bean gum, the succinum polysaccharide, the Carlow thujic acid, chitin, chitosan, carboxymethyl chitin, the viscosifier of agar etc.; The lower alcohol of ethanol etc.; The antioxidant of butylated hydroxytoluene, tocopherol, phytin. etc.; The antibacterial of benzoic acid, salicylic acid, sorbic acid, alkyl paraben, hexachlorophene's methylmethane etc.; The organic acid of acyl group sarcosine (for example sodium lauroyl sarcosine), glutathion, citric acid, malic acid, tartaric acid, lactic acid etc.; The vitamin(e) B group of vitamin A and derivant thereof, pyridoxine hydrochloride, vitamin B6 tripalmitate, vitamin B6 dicaprylate, vitamin B2 and derivant, vitamin B12, VITAMIN B15 and derivant thereof etc., the vitamin c class of ascorbic acid, ascorbic acid sulfuric ester (salt), ascorbic acid phosphoric acid esters (salt), Vitamin C dipalmitate etc., the vitamin E class of alpha-tocopherol, betatocopherol, Delta-Tocopherol, Vitamin E acetate etc., the vitamin D class, biotin, the vitamins of pantothenic acid, pantethin etc.; Nicotinamide, benzyl nicotinate, γ-Mi paddy phenol, allantoin, glycyrrhizic acid (salt), glycyrrhetinic acid and derivant thereof, the Fructus Gleditsia glycoside of thujaplicin, bisabolol, Eucalyptus, thymol, inositol, saikoside, ginsenoside, Fructus Luffae saponin, sapindoside etc.; The various medicaments of panthenol ether, ethinylestradiol, tranamic acid, arbutin, cepharanthine, intacellin etc.; Radix Rumicis Japonici, Radix Sophorae Flavescentis, spatterdock, orange, Salvia japonica Thunb., common milfoil, Qian Kui, work as medicine, Herba thymi vulgaris, Radix Angelicae Sinensis, the fish scale PiceameyeriRehd. Et Wils., birch, Herba Equiseti Arvinsis, Fructus Luffae, Aesculus chinensis Bunge, Herba Saxifragae, arnica montana, Bulbus Lilii, Radix Artemisia ordosicae, Radix Paeoniae, Aloe, Fructus Gardeniae, retinispora, the Mespilus germinica Linn extract, the West Herba Hyperici Erecti extract, the irisin extract, Ramulus Uncariae Cum Uncis extract, Folium Ginkgo extract, wild Thymi Serpylli Herba extract, Fructus Foeniculi extract, oolong tea extract, the Flos nymphaeae (Nymphaea teragona Georgi) extract, the Fructus rosae multiflorae extract, prolong the careless extract of life, Radix Scutellariae extract, Cortex Phellodendri extract, the Herba lamii barbati extract, Radix Glycyrrhizae extract, Fructus Gardeniae extract, black tea extract, Ramulus et Folium Tamaricis extract, Potentillw erecta[L., the Flos Rosae Multiflorae extract, Fructus Luffae extract, Folium Menthae extract, Herba Rosmarini Officinalis extract, the extract of the plant of royal jelly extract etc.; The color element; Single dodecanoic acid sorbitan esters; single hexadecanoic acid sorbitan esters; sesquialter oleic acid sorbitan esters; three oleic acid sorbitan esters; anhydrosorbitol polyoxyethylene ether monolaurate; anhydrosorbitol polyoxyethylene ether monostearate; polyethylene glycol monooleate; polyoxyethylene alkyl ether; the Polyethylene Glycol diether; the lauroyl diglycollic amide; the fatty acid isopropanol amide; maltol hydroxy fatty acid ether; the alkylation polysaccharide; alkyl androstanediol; the nonionic surfactant of Saccharum Sinensis Roxb. ester etc.; octadecyl trimethyl ammonium chloride; alkyl benzyl dimethyl ammonium chloride; the cationic surface active agent of dodecyl amine oxide etc.; hexadecanoic acid sodium; dodecanoic acid sodium; dodecanoic acid sodium; lauryl potassium sulfate; alkylsurfuric acid triethanolamine ether; turkey red oil; straight chain dodecyl phenyl-hydrogen-sulfate; the polyoxyethylene hardened castor oil maleic acid; the anionic surfactant of acyl group N-methyltaurine etc.; amphoteric surfactant; nertralizer; Delta-Tocopherol; the antioxidant of butylated hydroxytoluene etc., phenyl phenol; the antiseptic of p-Hydroxybenzoate etc.
In this manual, " fiber " final finished of comprising fibrous raw material, middle product and making.
Kind as fibrous raw material, have no particular limits, can enumerate the natural fiber of kapok, Pilus Caprae seu Ovis, silk, fiber crops etc., the chemical fibre of artificial silk, acetas etc., the synthetic fibers of nylon, polyester, polyurethane, polyethylene, polypropylene, polrvinyl chloride, acrylic acid etc.These fibers, what a kind of independent or 2 kinds of blending or its were above can.
As the centre product, can enumerate for example various forms of cotton products, fibre bundle, wool top, non-woven fabrics, fabric, knitting etc.
As the final finished of making, can enumerate underwear classes such as medicated underpants, vest, socks, Ms's panty hose, close-fitting corset, the clothes of western-style clothes trousers, skirt etc., towel, handkerchief, mask, glove etc.Wherein, the final finished of making of the preferred especially underwear class that directly contacts etc. or constitute the fiber of these finished products with skin.
Skin preparations for extenal use of the present invention and fiber except that xanthine derivative, can also contain other any composition that has lipid decomposition facilitation effect or suppress the accumulation of fat effect.As such composition, for example can enumerate, the Radix Bupleuri class of primary lavandula angustifolia, Garden lavender, leatherleaf lavandula angustifolia, Honoka Garden lavender, lavandula angustifolia Fructus Foeniculi, Italian Fructus Foeniculi, Herba Rosmarini Officinalis, Radix Bupleuri, Radix Bupleuri, African Radix Bupleuri etc., the teas of green tea, oolong tea etc., the plant extract of cacao bean, hop, Folium Perillae, Salvia farinacea, Cola, coffee etc., beta adrenergic effect analeptic, α epinephrine function inhibitor, bipyridine derivant etc.
Embodiment
Below, enumerate embodiment and specifically describe the present invention, but the present invention is not limited by following embodiment.
The investigation that percutaneous absorbs
The preparation that contains various oiliness compositions with the prescription shown in the table 1 (contrast, embodiment 1 to 3, Comparative Examples 1) preparation.In addition, in this test, use caffeine as xanthine derivative.Use level is all represented with the quality % to the preparation total amount.
Table 1
| Gradation composition | Contrast | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative Examples 1 |
| Caffeine | ??0.2 | ????0.2 | ????0.2 | ????0.2 | ????0.2 |
| Isooctadecanol | ??- | ????2.0 | ????- | ????- | ????- |
| Dermol DIPS | ??- | ????- | ????5.0 | ????- | ????- |
| Two neopentanoic acid tripropylene glycol esters | ??- | ????- | ????- | ????4.5 | ????- |
| Isostearic acid | ??- | ????- | ????- | ????- | ????2.0 |
| The alkyl-modified carboxyl group polyvinyl | ??0.1 | ????0.1 | ????0.1 | ????0.1 | ????0.1 |
| CVP Carbopol ETD2050 | ??0.12 | ????0.12 | ????0.12 | ????0.12 | ????0.12 |
| ??EDTA-3Na?2H 2O | ??0.1 | ????0.1 | ????0.1 | ????0.1 | ????0.1 |
| 1,3 butylene glycol | ??1.0 | ????1.0 | ????1.0 | ????1.0 | ????1.0 |
| Glycerol | ??1.0 | ????1.0 | ????1.0 | ????1.0 | ????1.0 |
| Ethanol | ??15.0 | ????15.0 | ????15.0 | ????15.0 | ????15.0 |
| Water | Surplus | Surplus | Surplus | Surplus | Surplus |
| Add up to | ??100 | ????100 | ????100 | ????100 | ????100 |
The experimental evidence band that percutaneous absorbs is peeled off (テ one プ ス ト リ Star ピ Application グ) method and is carried out.Band is peeled off (テ one プ ス ト リ Star ピ Application グ) method, is the conventional method of measuring the drug level in the horny layer.
In 3 participants of each group, test with following program:
(1) soaps wrist medial part before clean participant's two wrists
(2) the inboard coating of pro-wrist (20ml/20cm
2) preparation of prescription shown in the table 1 (contrast,
Embodiment 1 to 3, Comparative Examples 1)
(3) placed 6 hours
(4) soap the preceding wrist medial part of clean two wrists
(5) in the past peel off horny layer (at every turn use new adhesive tape this operation 8 times) repeatedly in the wrist inboard with adhesive tape (ニ チ バ Application system)
(6) extract caffeine with ion exchange water from adhesive tape
(7) with the caffeine in the HPLC dose liquid
From the caffeine amount that the horny layer by tape stripping reclaims, calculate interior concentration (the μ g/cm of horny layer of caffeine
2), obtain 3 participants' meansigma methods.Table 2 shows its result.
The investigation that table 2 percutaneous absorbs
| Sample | Concentration (μ g/cm in the horny layer of caffeine 2) |
| Contrast | ????0.080 |
| Embodiment 1 (isooctadecanol) | ????0.135 |
| Embodiment 2 (Dermol DIPS) | ????0.103 |
| Embodiment 3 (two neopentanoic acid tripropylene glycol esters) | ????0.096 |
| Comparative Examples 1 (isostearic acid) | ????0.081 |
As known from Table 2, by cooperating jointly with xanthine derivative, can promote the percutaneous of xanthine derivative to absorb with isooctadecanol, Dermol DIPS or two neopentanoic acid tripropylene glycol esters.
Below, skin preparations for extenal use Formulation Example of the present invention is showed as embodiment.In addition, use level is all represented with the quality % with respect to the preparation total amount.
Embodiment 4: astringent
Ethanol 5
Glycerol 1
1,3 butylene glycol 5
Polyoxyethylene polyoxypropylene decyl myristyl ether 0.2
Sodium hexameta phosphate 0.03
Trimethyl glycine 1
Poly (sodium aspartate) 0.1
Alpha-tocopherol 2-L-sodium ascorbyl phosphate diester potassium 0.1
Isooctadecanol 1
Caffeine 0.2
Herba Houttuyniae extract 0.1
Thiolaurine 0.1
Green tea extract 0.1
The West Folium Menthae extract 0.1
HEDTA3 sodium 0.1
CVP Carbopol ETD2050 0.05
Potassium hydroxide 0.02
Phenyl phenol is an amount of
The Purified Water surplus
Spice is an amount of
Embodiment 5:O/W type emulsion
Dimethyl polysiloxane 3
Decamethyl ring-type five polysiloxanes 4
Ethanol 15
Glycerol 6
1,3 butylene glycol 5
Glucam E-10 3
Oleum helianthi 1
Squalane 2
Isooctadecanol 5
Dermol DIPS 0.5
Potassium hydroxide 0.1
Sodium hexameta phosphate 0.05
HP-0.1
Caffeine 1
The West Herba Hyperici Erecti extract 0.5
Glycyrrhizic acid dipotassium 0.05
Folium Eriobotryae fermented product 0.1
L-sodium glutamate 0.05
Fructus Foeniculi extract 0.1
Yeast extract 0.1
Essential lavender oil 0.1
Radix Rehmanniae extract 0.1
Dimorpholino tetrahydro pyridazine ketone 0.1
Menthol 1.0
HANSHENGJIAO 0.1
CVP Carbopol ETD2050 0.1
Acrylic acid alkyl methacrylate copolymer (ペ ミ ユ レ Application TR-1) 0.1
Pigment is an amount of
P-Hydroxybenzoate is an amount of
The Purified Water surplus
Embodiment 6:O/W type emulsion
Dimethyl polysiloxane 2
Docosane alcohol 1
Batilol 0.5
Glycerol 5
1,3 butylene glycol 7
Erithritol 2
Fixed oil 3
Squalane 6
Isooctadecanol 5
Two neopentanoic acid dipropylene glycol esters 0.5
Four-2 ethyl hexanoic acid pentaerythritol ester 2
Isostearic acid polyoxyethylene glyceride 1
Monostearate polyoxyethylene glyceride 1
Caffeine 0.01
Mespilus germinica Linn extract 1
Potassium hydroxide is an amount of
Sodium hexameta phosphate 0.05
Phenyl phenol is an amount of
CVP Carbopol ETD2050 0.1
The Purified Water surplus
Embodiment 7:O/W type frost
Liquid paraffin 3
Vaseline 1
Dimethyl polysiloxane 1
Stearyl alcohol 1.8
Docosane alcohol 1.6
Glycerol 8
Dipropylene glycol 5
Macadimia nut oil 2
Fixed oil 3
Squalane 6
Stearic acid 2
Isooctadecanol 10
Two neopentanoic acid binaryglycol esters 1
Hydroxy stearic acid cholesterol ester 0.5
2 ethyl hexanoic acid cetyl ester 4
Polyoxyethylene hardened castor oil 0.5
Self-emulsifying type glyceryl monostearate 3
Potassium hydroxide 0.15
Sodium hexameta phosphate 0.05
Trimethyl glycine 2
Alpha-tocopherol 2-L-sodium ascorbyl phosphate diester potassium 1
Caffeine 0.5
Theobromine sodium formate 1
Herba Houttuyniae extract 0.5
Tocopheryl acetate 0.1
Sweet tea extract 0.1
P-Hydroxybenzoate is an amount of
Sodium versenate 0.05
The 4-tert-butyl group-4 '-methoxy dibenzoyl methylmethane 0.05
Di-p-methoxy cinnamic acid list-2 ethyl hexanoic acid glyceride 0.05
Pigment is an amount of
CVP Carbopol ETD2050 0.05
The Purified Water surplus
Embodiment 8: gel
Glycerol 2
1,3 butylene glycol 5
Two neopentanoic acid tripropylene glycol esters 1
Potassium hydroxide 0.1
Fish collagen 20
Xanthine 0.1
Fructus Foeniculi extract 1
Sodium versenate 0.05
CVP Carbopol ETD2050 0.25
P-Hydroxybenzoate is an amount of
The Purified Water surplus
Embodiment 9: the dipping facial film
Glycerol 1
1,3 butylene glycol 8
Xylitol 2
Polyethylene glycol 1500 2
Dermol DIPS 1
Oil of rosemary 0.01
Sage oil 0.1
Caffeine 5
Garden lavender 0.5
Citric acid 0.02
Sodium citrate 0.08
Sodium hexameta phosphate 0.01
HP-0.1
Aloe extraction solution 0.1
Birch extract 0.1
Essential lavender oil 0.01
HANSHENGJIAO 0.05
CVP Carbopol ETD2050 0.15
P-Hydroxybenzoate is an amount of
The Purified Water surplus
Embodiment 10:W/O type frost
Glycerol 1.0
Xylitol 1.0
The Purified Water surplus
Annular dimethyl polysiloxane 20.0
Isooctadecanol 10
Two neopentanoic acid tripropylene glycol esters 1
Dermol DIPS 1
Polyvinyl alcohol 2.0
トリオクノイン(Trioctanoin)???????????????3.0
Hexadecanol 0.1
The polydimethylsiloxane 2.5 that contains polyoxyethylene or polyoxypropylene side chain
The reactant 1.5 of dihydro tallow alkyl dimethyl ammonium chloride and hectorite
Caffeine 1
P-Hydroxybenzoate is an amount of
Pigment is an amount of
Spice is an amount of
From these skin preparations for extenal use of embodiment 4 to 10, all has excellent lipid metabolism facilitation.
Claims (7)
1. skin preparations for extenal use contains xanthine derivative and is selected from a kind or 2 kinds or its above oiliness composition in the group that isooctadecanol, Dermol DIPS and two neopentanoic acid poly alkylene glycol esters form.
2. skin preparations for extenal use as claimed in claim 1 is characterized in that containing isooctadecanol.
3. skin preparations for extenal use as claimed in claim 1 is characterized in that described xanthine derivative is a caffeine.
4. skin preparations for extenal use as claimed in claim 2 is characterized in that described xanthine derivative is a caffeine.
5. as each described skin preparations for extenal use of claim 1～4, it is characterized in that, is to be used to promote fat-splitting skin preparations for extenal use.
6. skin preparations for extenal use as claimed in claim 5 is characterized in that, is the weight reducing skin preparations for extenal use.
7. fiber contains xanthine derivative and is selected from a kind or 2 kinds or its above oiliness composition in the group that isooctadecanol, Dermol DIPS and two neopentanoic acid poly alkylene glycol esters form.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004041850A JP4515109B2 (en) | 2004-02-18 | 2004-02-18 | Skin external preparation and fiber having a lipolysis promoting effect |
| JP041850/2004 | 2004-02-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1679581A true CN1679581A (en) | 2005-10-12 |
| CN100475213C CN100475213C (en) | 2009-04-08 |
Family
ID=35015379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100085049A Active CN100475213C (en) | 2004-02-18 | 2005-02-18 | Composition of an external dermatological agent and fibers with effect of promoting lipid decomposition |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP4515109B2 (en) |
| CN (1) | CN100475213C (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4965844B2 (en) * | 2005-10-20 | 2012-07-04 | 株式会社東芝 | Semiconductor memory device |
| WO2009093104A2 (en) * | 2008-01-25 | 2009-07-30 | B & T S.R.L | Use of transesterified olive oil in the cosmetic field |
| KR101619085B1 (en) * | 2009-09-30 | 2016-05-11 | (주)아모레퍼시픽 | Cosmetic composition for massage |
| JP2014091681A (en) * | 2012-11-01 | 2014-05-19 | Pixy:Kk | Composition comprising skin external preparation and inclusion complex |
| JP2015205874A (en) * | 2014-04-11 | 2015-11-19 | 御木本製薬株式会社 | oil-in-water emulsion composition |
| JP2016222611A (en) * | 2015-06-01 | 2016-12-28 | 大同化成工業株式会社 | Composition for external preparation |
| JP6921493B2 (en) * | 2015-10-30 | 2021-08-18 | 小林製薬株式会社 | Oil-in-water emulsified composition |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2671487B1 (en) * | 1991-01-14 | 1993-03-19 | Oreal | USE OF A GROWTH FACTOR IN A SLIMMING COMPOSITION. |
| JP3595057B2 (en) * | 1996-02-09 | 2004-12-02 | 花王株式会社 | Sheet-shaped cosmetic composition |
| JPH09295932A (en) * | 1996-05-02 | 1997-11-18 | Nonogawa Shoji Kk | Slimming agent composition for cosmetic |
| JPH10101546A (en) * | 1996-09-27 | 1998-04-21 | Shiseido Co Ltd | Preparation for external use for skin |
| BR9713348A (en) * | 1996-11-12 | 2000-08-08 | Dov Tamarkin | Method for treating dermatological disorders |
| JPH11269079A (en) * | 1998-03-17 | 1999-10-05 | Shiseido Co Ltd | Preparation for external use for skin for promoting lipid degradation |
| JP4112794B2 (en) * | 1999-10-29 | 2008-07-02 | 株式会社資生堂 | Hair nourishing agent or gray hair inhibitor whose hair absorption is accelerated by isostearyl alcohol, and method of using isostearyl alcohol for promoting hair absorption |
| JP2002302469A (en) * | 2001-03-30 | 2002-10-18 | Shiseido Co Ltd | Neopentanoic acid alkyl polyglycol |
| TWI314057B (en) * | 2001-09-26 | 2009-09-01 | Shiseido Co Ltd |
-
2004
- 2004-02-18 JP JP2004041850A patent/JP4515109B2/en not_active Expired - Lifetime
-
2005
- 2005-02-18 CN CNB2005100085049A patent/CN100475213C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP4515109B2 (en) | 2010-07-28 |
| JP2005232058A (en) | 2005-09-02 |
| CN100475213C (en) | 2009-04-08 |
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