CN116369416A - Dendrobium officinale gel soft sweet with function of relieving visual fatigue and preparation method thereof - Google Patents
Dendrobium officinale gel soft sweet with function of relieving visual fatigue and preparation method thereof Download PDFInfo
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- CN116369416A CN116369416A CN202310498386.2A CN202310498386A CN116369416A CN 116369416 A CN116369416 A CN 116369416A CN 202310498386 A CN202310498386 A CN 202310498386A CN 116369416 A CN116369416 A CN 116369416A
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- dendrobium candidum
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- KZEVSDGEBAJOTK-UHFFFAOYSA-N 1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)-2-[5-[2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]ethanone Chemical compound N1N=NC=2CN(CCC=21)C(CC=1OC(=NN=1)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)=O KZEVSDGEBAJOTK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/44—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/90—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in food processing or handling, e.g. food conservation
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a dendrobium candidum gel soft sweet with a visual fatigue relieving function and a preparation method thereof. Compared with the defects of single added component and limited treatment function of the health care product for relieving the asthenopia in the market at present, the invention has the advantages of overall conditioning, prevention and cure and the combination of the treatment of the asthenopia, has zero 0 sugar burden, has definite function of relieving the asthenopia, is more in line with the concept of low sugar diet of modern people, and fills the gap of the health care product for relieving the asthenopia in the market.
Description
Technical Field
The invention belongs to the technical field of health-care foods, and particularly relates to dendrobium candidum gel soft sweets with a visual fatigue relieving function and a preparation method thereof.
Background
In recent years, network technology is rapidly developed, various video display terminals such as mobile phones and computers continuously cover work, life and study of people, more and more people, especially young people generate a series of asthenopia symptoms such as dry eyes, eye ache, blurred vision, foreign body sensation, lacrimation and the like due to long-term use of video terminal equipment, and the life quality and the working efficiency of people are seriously influenced.
The need to alleviate asthenopia covers almost all age groups of people, but treatment of asthenopia is a long-term process. The existing therapeutic drugs can cause a certain liver burden after being taken for a long time, most of health-care foods with the effect of relieving visual fatigue in the market are simple in components, most of the health-care foods only contain two components of blueberry and lutein ester, only aim at single visual fatigue generation cause, and the lutein ester can cause skin yellowing and a series of gastrointestinal discomfort symptoms after being taken for a long time, so that the health-care foods have certain limitation on visual fatigue patients with gastrointestinal dysfunction. In addition, many products on the market are added with sucrose, fructose, saccharin and other components, so that the problems of dental caries, obesity and the like are more likely to be caused, even the risk of diabetes is caused for the old, and the health care products for preventing and treating asthenopia with definite curative effect and healthy formula are still lacking in the market at present.
Dendrobium officinale has the effects of nourishing yin, improving eyesight, clearing heat, promoting the production of body fluid and the like, has better treatment effects on yin deficiency, dry mouth, polydipsia, stomach yin deficiency, fire excess due to yin deficiency and dark eyes, and is also taken as a good product for maintaining eyes by traditional Chinese medicine doctors; the addition of a plurality of medicinal and edible traditional Chinese medicinal materials such as medlar, chrysanthemum and the like can also play a good role in relieving visual fatigue.
Disclosure of Invention
Aiming at the problems, the invention aims to provide the dendrobium candidum gel soft sweets with the function of relieving visual fatigue and the preparation method thereof.
The specific technical scheme is as follows:
the invention provides dendrobium candidum gel soft sweet with a visual fatigue relieving function, which comprises the following raw materials in percentage by mass: 1 to 15 percent of dendrobium candidum, medlar and chrysanthemum mixed extract, 1 to 15 percent of gel, 20 to 50 percent of sweetener, 0.2 to 2 percent of sour agent and the balance of purified water.
The invention also provides a preparation method of the dendrobium candidum gel soft sweet with the function of relieving visual fatigue, which comprises the following steps:
s1, pre-dissolving gel: weighing the gel according to the mass ratio, uniformly mixing the gel with purified water, heating and stirring the mixture, keeping the temperature at 60-80 ℃ until the gel fully absorbs water and swells, dissolving the gel into transparent glue solution, and keeping the temperature at 60-80 ℃ to obtain a feed liquid A for later use;
s2, preparing a sugar solution: weighing sweetener according to the mass ratio, heating to 100-110 ℃ until sugar powder is completely melted, dipping the sugar liquid by using a stirring rod for observation after the sugar liquid is light yellow, clear and transparent, and stopping heating when the sugar liquid can flow down along the rod to form a thin strip shape, and keeping the temperature of the sugar liquid at 80-90 ℃ to obtain a feed liquid B for later use;
s3, blending: stirring and mixing the feed liquid A and the feed liquid B uniformly under a constant-temperature water bath at 75-85 ℃ to obtain feed liquid C, adding a dendrobium candidum, medlar and chrysanthemum mixed extract and an acidulant in a certain mass ratio into the feed liquid C, and mixing and stirring uniformly to obtain feed liquid D for later use;
s4, casting and molding: smearing a layer of edible oil on the mould before casting, and casting the uniform and stable feed liquid D in the prepared mould when the feed liquid D is hot;
s5, cooling and demolding: cooling the poured mold in a refrigerator at-5 deg.c for 1-2 hr to separate from the mold;
s6, airing and packaging: and (3) placing the demolded dendrobium candidum in a constant temperature and humidity environment for drying and dewatering at the temperature of 20-25 ℃ and the humidity of 40-60%, drying for 24-48 hours, and packaging the dried dendrobium candidum gel soft candy to obtain the dendrobium candidum gel soft candy.
Preferably, in step S3, the preparation method of the dendrobium candidum mixed extract includes: pulverizing Dendrobium officinale, wolfberry fruit and chrysanthemum, adding purified water, boiling at 100-120 ℃ for extraction, concentrating the filtrate under reduced pressure, freeze-drying, pulverizing, and sieving with a 60-120 mesh sieve to obtain the dendrobium officinale, wolfberry fruit and chrysanthemum mixed extract.
Preferably, the ratio of the dendrobium candidum to the medlar to the chrysanthemum is 1-10:2-8:1-6.
Preferably, the feed liquid ratio of the dendrobium candidum, medlar and chrysanthemum mixed extract to purified water is 1-5 g:10-50 mL.
Preferably, the extraction times are 1-5 times, and the extraction time is 1-5 hours.
Preferably, the gel is one or more of gelatin, pectin, k-carrageenan and konjac gum; the sweetener is one or more of sorbitol, erythritol, maltitol, xylitol and mannitol; the sour agent is one or more of citric acid and DL-malic acid.
Compared with the prior art, the invention has the beneficial effects that:
(1) According to the invention, dendrobium candidum, medlar and chrysanthemum are subjected to co-extraction, and compared with the extraction of equivalent single components, the co-extraction can obviously extract the contents of polysaccharide and flavonoid active ingredients, so that the asthenopia relieving function of the soft sweet is further improved; the konjac gum, k-carrageenan, pectin and gelatin are used as the gel, so that the stability and the taste of the soft sweet product are enhanced; because the dendrobium candidum mixed extract is added in the soft sweet, the soft sweet contains various polysaccharide and flavonoid components, and has special flavor; and sugar-free sugar substitutes such as sorbitol, erythritol, maltitol, xylitol and mannitol are used as flavoring agents, so that the addition of '0 sucrose' is realized, and the concept of healthy and low-sugar diet of modern people is more met.
(2) The dendrobium candidum gel soft sweet has excellent anti-asthenopia function, can remarkably relieve a series of asthenopia symptoms such as dry eyes, eye soreness, blurred vision, foreign body sensation, lacrimation and the like caused by long-term eye use, and has rich nutrition, definite curative effect and good market development prospect.
Detailed Description
In order that those skilled in the art will better understand the technical scheme of the present invention, the present invention will be further described with reference to specific examples and clinical data, but the examples are not intended to limit the present invention.
Example 1
A preparation method of dendrobium candidum gel soft sweet with the function of relieving visual fatigue comprises the following raw materials in percentage by mass: dendrobium officinale, wolfberry fruit and chrysanthemum mixed extract 10%, gelatin 12%, sweetener 30%, acidulant 0.4% of citric acid and DL-malic acid (1:1), and the balance of purified water.
The preparation method of the dendrobium candidum gel soft sweet comprises the following steps:
s1, pre-dissolving gel: weighing gelatin according to mass percent, uniformly mixing the gelatin with the rest of purified water, heating and stirring the mixture, keeping the temperature at 60-80 ℃ until the colloid fully absorbs water and swells, dissolving the colloid into transparent glue solution, and keeping the temperature at 60-80 ℃ to obtain a feed liquid A for later use;
s2, preparing a sugar solution: weighing xylitol according to mass percent, heating to 100-110 ℃ until sugar powder is completely melted, dipping the sugar liquid by using a stirring rod for observation after the sugar liquid is light yellow, clear and transparent, and stopping heating when the sugar liquid can flow down along the rod to form a thin strip shape, and keeping the temperature of the sugar liquid at 80-90 ℃ to obtain a feed liquid B for later use;
s3, blending: stirring and mixing the feed liquid A and the feed liquid B uniformly under a constant-temperature water bath at 75 ℃ to obtain feed liquid C, adding dendrobium candidum, medlar and chrysanthemum mixed extract, citric acid and DL-malic acid into the feed liquid C according to mass percent, and stirring uniformly to obtain feed liquid D for later use;
s4, casting and molding: smearing a layer of edible oil on the mould before casting, and casting the uniform and stable feed liquid D in the prepared mould when the feed liquid D is hot;
s5, cooling and demolding: cooling the cast mold in refrigerator at the temperature ofCooling for 1-2 h at 5-5 ℃ and then separating from the die;
s6, airing and packaging: and (3) placing the demolded soft sweet in a constant temperature and humidity environment for drying and dewatering at the temperature of 20 ℃ and the humidity of 40%, drying for 48 hours, and packaging the dried dendrobium candidum composition gel soft sweet to obtain the dendrobium candidum gel soft sweet.
S3, the preparation method of the dendrobium candidum mixed extract comprises the following steps: after 20g of dendrobium candidum, 40g of medlar and 60g of chrysanthemum are crushed, adding purified water according to the feed liquid ratio of the mixed extract of dendrobium candidum, medlar and chrysanthemum to 1g to 15mL of water, heating and reflux-extracting for 1 time at 100 ℃ for 1.5h each time, concentrating the filtrate under reduced pressure, freeze-drying, crushing and sieving with a 60-mesh sieve to obtain the mixed extract of dendrobium candidum.
Example 2
A preparation method of dendrobium candidum gel soft sweet with the function of relieving visual fatigue comprises the following raw materials in percentage by mass: dendrobium officinale, wolfberry fruit and chrysanthemum mixed extract 10%, gelatin 10%, sweetener 30%, acidulant 0.2% of citric acid and DL-malic acid (1:1), and the balance of purified water.
The preparation method is the same as in example 1, except that: s3, the preparation method of the dendrobium candidum mixed extract comprises the following steps: after 30g of dendrobium candidum, 40g of medlar and 50g of chrysanthemum are crushed, adding purified water according to the feed liquid ratio of a dendrobium candidum mixture to water of 1g to 15mL, heating and refluxing for extraction for 2 times at 100 ℃ for 2 hours each time, concentrating filtrate under reduced pressure, freeze-drying, crushing and sieving with a 60-mesh sieve to obtain the dendrobium candidum mixed extract.
Example 3
A preparation method of dendrobium candidum gel soft sweets comprises the following raw materials in percentage by mass: dendrobium officinale, wolfberry fruit and chrysanthemum mixed extract 12%, gelatin 8%, sweetener 25% maltitol and xylitol mixed sugar alcohol (1:1), acidulant 0.4% citric acid and DL-malic acid (1:1) and the balance of purified water.
The preparation method is the same as in example 1, except that in S3, the preparation method of the dendrobium candidum mixed extract is as follows: after 40g of dendrobium candidum, 20g of medlar and 60g of chrysanthemum are crushed, adding purified water according to the feed liquid ratio of a dendrobium candidum mixture to 1g of water to 20mL, heating and reflux-extracting for 2 times at 100 ℃ for 1.5h each time, concentrating filtrate under reduced pressure, freeze-drying, crushing and sieving with a 60-mesh sieve to obtain the dendrobium candidum mixed extract.
Example 4
A preparation method of dendrobium candidum gel soft sweets comprises the following raw materials in percentage by mass: 14% of dendrobium candidum, medlar and chrysanthemum mixed extract, 6% of gelatin, 30% of sweetener, 0.4% of citric acid and DL-malic acid (1:1) of acidulant and the balance of purified water.
The preparation method is the same as in example 1, except that in S3, the preparation method of the dendrobium candidum mixed extract is as follows: after 20g of dendrobium candidum, 60g of medlar and 40g of chrysanthemum are crushed, adding purified water according to the feed liquid ratio of the dendrobium candidum mixture to 1g of water to 20mL, heating and reflux-extracting for 3 times at 100 ℃ for 2 hours each time, concentrating filtrate under reduced pressure, freeze-drying, crushing and sieving with a 60-mesh sieve to obtain the dendrobium candidum mixed extract.
Example 5
A preparation method of dendrobium candidum gel soft sweets comprises the following raw materials in percentage by mass: dendrobium officinale, wolfberry fruit and chrysanthemum mixed extract 12%, gelatin 6%, sweetener 35% maltitol and xylitol mixed sugar alcohol (1:1), acidulant 0.3% citric acid and DL-malic acid (1:1) and the balance of purified water.
The preparation method is the same as in example 1, except that in S3, the preparation method of the dendrobium candidum mixed extract is as follows: after 50g of dendrobium candidum, 50g of medlar and 20g of chrysanthemum are crushed, adding purified water according to the feed liquid ratio of a dendrobium candidum mixture to 1g of water to 25mL, heating and refluxing for extraction for 3 times at 100 ℃ for 1.5h each time, concentrating filtrate under reduced pressure, freeze-drying, crushing and sieving with a 60-mesh sieve to obtain the dendrobium candidum mixed extract.
Example 6
A preparation method of dendrobium candidum gel soft sweets comprises the following raw materials in percentage by mass: dendrobium officinale, wolfberry fruit and chrysanthemum mixed extract 12%, gelatin 8%, sweetener 30% maltitol and xylitol mixed sugar alcohol (1:1), acidulant 0.4% citric acid and DL-malic acid (1:1) and the balance of purified water.
The preparation method is the same as in example 1, except that in S3, the preparation method of the dendrobium candidum mixed extract is as follows: after 40g of dendrobium candidum, 40g of medlar and 40g of chrysanthemum are added with purified water according to the feed liquid ratio of the dendrobium candidum mixture to 1g of water to 20mL, the mixture is heated and refluxed for 2 times at 100 ℃ and each time for 2.5 hours, the filtrate is concentrated under reduced pressure, freeze-dried, crushed and then screened by a 60-mesh sieve, and the dendrobium candidum mixed extract is obtained.
Sensory evaluation of Dendrobium officinale gel soft sweets
Performing sensory evaluation on the dendrobium candidum gel soft sweets prepared in the embodiments 1-6 according to the general principle and method established by a food sensory evaluation index system, placing the samples in a clean and dry white porcelain plate, and visually inspecting the shape and color of the samples; then cutting by a knife according to a quartering method, and observing tissues and impurities; taste and mouthfeel were tasted and evaluated. The gel candy is comprehensively scored by adopting a sensory fuzzy evaluation method, and the total number of the evaluators is 10. And collecting five evaluation indexes of 10 evaluation staff on the appearance color, texture, structure, viscosity, chewiness, taste, flavor and flavor of different gel candies, performing human sense evaluation on the five evaluation indexes, wherein the weight coefficient of each evaluation index is 0.2, dividing the score obtained in each score threshold of each index by the total number of the evaluation staff (10), and multiplying the score by the weight coefficient to obtain a sense fuzzy evaluation matrix. The sensory blurring evaluation matrix is multiplied by the corresponding scores (the scores of the extreme difference, the middle, the good and the excellent are respectively 50, 60, 70, 80 and 90), and the sum is carried out to obtain the comprehensive score. The sensory blurring score criteria and the results are shown in tables 1 and 2.
TABLE 1 sensory blur scoring criteria
TABLE 2 sensory blur scoring results
As can be seen from table 2, example 6 has the highest overall sensory score, followed by example 2; the overall sensory scores are in sequence from high to low, namely, example 6> example 2> example 3> example 1> example 5> example 4, and the added amount of gelatin has a great influence on the texture structure, viscosity, chewiness and mouthfeel of the product; example 6 has good sensory evaluation, and the prepared dendrobium candidum gel candy has uniform color, sweet and sour taste, good chewing property and special flavor of traditional Chinese medicines.
Detection of content of active ingredients of dendrobium candidum mixed extract for relieving visual fatigue
And (3) measuring the total polysaccharide content: determining the total polysaccharide content in the dendrobium candidum mixed extract according to a phenol sulfuric acid method; determination of total flavone content: and determining the total flavone content in the dendrobium candidum mixed extract according to an aluminum nitrate color development method. The content measurement results are shown in Table 3.
TABLE 3 determination of the content of Dendrobium officinale Mixed extracts
Test for crowd to test food
40 persons with ages of 25-35 years old are selected, and a small group of evaluation persons is formed by using a computer for a long time and excessively using eyes (40 persons are all used for a long time, working for more than 8 hours before a computer screen every day) and is divided into a test feeding group and a control group, wherein 20 persons are respectively in the test feeding group and the control group. Test panel personnel orally administer the sample of example 6 2 times per day, 1 at a time; the control group personnel orally take blank samples prepared by the dendrobium candidum mixed extract, the blank samples are taken 2 times a day and 1 time each time, feedback information of 40 evaluation personnel is collected after the dendrobium candidum mixed extract is eaten for 7 days, and the crowd test results are shown in Table 4.
Table 4 results of population test feeding
From the test results of the test food in example 6, it can be seen that: the dendrobium candidum gel candy is a health food capable of effectively relieving asthenopia symptoms, and can relieve a series of symptoms such as dry eyes, unsmooth eyes, blurred vision and the like which occur in long-term use.
The technical features of the above-described embodiments may be arbitrarily combined, and all possible combinations of the technical features are not described for brevity of description, however, as long as there is no contradiction between the combinations of the technical features, they should be considered as the scope of the description.
The above examples illustrate only a few embodiments of the invention, which are described in detail and are not to be construed as limiting the scope of the invention. It should be noted that it will be apparent to those skilled in the art that several variations and modifications can be made without departing from the spirit of the invention, which are all within the scope of the invention. Accordingly, the scope of protection of the present invention is to be determined by the appended claims.
Claims (7)
1. The dendrobium candidum gel soft sweet with the function of relieving visual fatigue is characterized by comprising the following raw materials in percentage by mass: 1 to 15 percent of dendrobium candidum, medlar and chrysanthemum mixed extract, 1 to 15 percent of gel, 20 to 50 percent of sweetener, 0.2 to 2 percent of sour agent and the balance of purified water.
2. A method for preparing the dendrobium candidum gel soft sweets with the function of relieving visual fatigue according to claim 1, which is characterized by comprising the following steps:
s1, pre-dissolving gel: weighing the gel according to the mass ratio, uniformly mixing the gel with purified water, heating and stirring the mixture, keeping the temperature at 60-80 ℃ until the gel fully absorbs water and swells, dissolving the gel into transparent glue solution, and keeping the temperature at 60-80 ℃ to obtain a feed liquid A for later use;
s2, preparing a sugar solution: weighing sweetener according to the mass ratio, heating to 100-110 ℃ until sugar powder is completely melted, dipping the sugar liquid by using a stirring rod for observation after the sugar liquid is light yellow, clear and transparent, and stopping heating when the sugar liquid can flow down along the rod to form a thin strip shape, and keeping the temperature of the sugar liquid at 80-90 ℃ to obtain a feed liquid B for later use;
s3, blending: stirring and mixing the feed liquid A and the feed liquid B uniformly under a constant-temperature water bath at 75-85 ℃ to obtain feed liquid C, adding the dendrobium candidum, the medlar and chrysanthemum mixed extract and the sour agent into the feed liquid C, and mixing and stirring uniformly to obtain feed liquid D for later use;
s4, casting and molding: pouring the uniform and stable feed liquid D into a prepared mould while the feed liquid D is hot;
s5, cooling and demolding: cooling the poured mold in a refrigerator for 1-2 h, and demolding;
s6, airing and packaging: and (3) placing the demolded dendrobium candidum in a constant temperature and humidity environment for drying and dewatering at the temperature of 20-25 ℃ and the humidity of 40-60%, drying for 24-48 hours, and packaging the dried dendrobium candidum gel soft candy to obtain the dendrobium candidum gel soft candy.
3. The preparation method of the dendrobium candidum, medlar and chrysanthemum mixed extract according to claim 2, wherein the preparation method is that after the dendrobium candidum, medlar and chrysanthemum are crushed, purified water is added, the mixture is boiled and extracted at 100-120 ℃, the filtrate is decompressed, concentrated, freeze-dried and crushed and then is sieved by a 60-120 mesh sieve, and the dendrobium candidum, medlar and chrysanthemum mixed extract is obtained.
4. The preparation method of claim 3, wherein the ratio of Dendrobium officinale, lycium barbarum fruit and chrysanthemum is 1-10:2-8:1-6.
5. The preparation method of claim 4, wherein the ratio of the mixed extract of dendrobium candidum, medlar and chrysanthemum to purified water is 1-5 g/10-50 mL.
6. The method of claim 5, wherein the number of extraction steps is 1 to 5 and the extraction time is 1 to 5 hours.
7. The preparation method according to claim 2, wherein the gelling agent is one or a mixture of a plurality of gelatin, pectin, k-carrageenan and konjac gum; the sweetener is one or more of sorbitol, erythritol, maltitol, xylitol and mannitol; the sour agent is one or more of citric acid and DL-malic acid.
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104147380A (en) * | 2014-08-21 | 2014-11-19 | 漳州片仔癀药业股份有限公司 | Pharmaceutical composition for relieving asthenopia, preparation method and applications thereof |
CN104225265A (en) * | 2014-09-12 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for alleviating asthenopia |
CN108403954A (en) * | 2018-06-07 | 2018-08-17 | 贵州赤水国礼金钗石斛发展有限公司 | A kind of HERBA DENDROBII alleviates visual fatigue health products and preparation method thereof |
CN109198138A (en) * | 2017-07-05 | 2019-01-15 | 云南天士力帝泊洱生物茶集团有限公司 | A kind of gel soft candy and preparation method thereof containing dendrobium candidum |
-
2023
- 2023-05-06 CN CN202310498386.2A patent/CN116369416A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104147380A (en) * | 2014-08-21 | 2014-11-19 | 漳州片仔癀药业股份有限公司 | Pharmaceutical composition for relieving asthenopia, preparation method and applications thereof |
CN104225265A (en) * | 2014-09-12 | 2014-12-24 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for alleviating asthenopia |
CN109198138A (en) * | 2017-07-05 | 2019-01-15 | 云南天士力帝泊洱生物茶集团有限公司 | A kind of gel soft candy and preparation method thereof containing dendrobium candidum |
CN108403954A (en) * | 2018-06-07 | 2018-08-17 | 贵州赤水国礼金钗石斛发展有限公司 | A kind of HERBA DENDROBII alleviates visual fatigue health products and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
王元川,等: "响应面法优化铁皮石斛软糖配方及其抗氧化活性分析", 食品工业科技, pages 127 - 128 * |
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