CN116369413A - Preparation method of Sanhuang eye-protecting candy tablet - Google Patents
Preparation method of Sanhuang eye-protecting candy tablet Download PDFInfo
- Publication number
- CN116369413A CN116369413A CN202211672325.5A CN202211672325A CN116369413A CN 116369413 A CN116369413 A CN 116369413A CN 202211672325 A CN202211672325 A CN 202211672325A CN 116369413 A CN116369413 A CN 116369413A
- Authority
- CN
- China
- Prior art keywords
- eye
- protecting
- provitamin
- parts
- sanhuang
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 235000009508 confectionery Nutrition 0.000 title claims abstract description 56
- 239000009705 sanhuang Substances 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000011648 beta-carotene Substances 0.000 claims abstract description 59
- 235000013734 beta-carotene Nutrition 0.000 claims abstract description 59
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims abstract description 59
- 239000000843 powder Substances 0.000 claims abstract description 52
- 238000000605 extraction Methods 0.000 claims abstract description 41
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- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 24
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- 238000001694 spray drying Methods 0.000 claims abstract description 11
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Nutrition Science (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a preparation method of a Sanhuang eye-protecting candy tablet, which comprises the following steps: extracting flos Tagetis Erectae particles by subcritical extraction to obtain fat-soluble extract rich in provitamin A, concentrating under reduced pressure, and vacuum lyophilizing to obtain provitamin A; taking provitamin A as a core material, taking embedding agent and maltodextrin as wall materials, and adding other main materials, flavoring agent and filler, emulsifying, homogenizing and spray drying to obtain microcapsule powder; adding lubricant into the obtained microcapsule powder, tabletting, and forming to obtain the Sanhuang eye-protecting candy tablet. The Sanhuang eye-protecting candy tablet product prepared by the invention has good taste, easy chewing, high content of eye-protecting core component, good activity, convenient and quick eating and can be used for people with different degrees of uncomfortable symptoms such as dry eyes, eye astringents, eye swelling, eye fatigue, night blindness, mosquito and the like.
Description
Technical Field
The invention belongs to the technical field of preparation of eye-protecting candy pieces, and particularly relates to a preparation method of a Sanhuang eye-protecting candy piece.
Background
In recent years, the aging process of population in China is aggravated, the number of netizens is rapidly increased, the problems of dry eyes, acid distension, blurred vision, vision degradation, pathological changes, blindness and the like are highlighted, people are enabled to pay more attention to eye health, and meanwhile, the demands of people on eye health supplements are also accelerated.
Children and teenagers can prevent myopia. The incidence rate of myopia of teenagers in China reaches 67%, and the deficiency of nutrition for vision development is removed from the influence of the increase of academic pressure and electronic equipment, and is also an important factor for influencing the vision of teenagers.
Executive and mobile phones can relieve asthenopia. The crowd is exposed to high-energy blue light such as mobile phones and computers for a long time every day, so that the problems of eye fatigue, itching, ache, digital vision syndrome and the like are easily caused, and further symptoms such as deepening myopia, double vision and incapacity of concentrating attention are caused.
The eye health is not neglected in the silver hair family. China gradually walks into an aging society, and age-related macular degeneration becomes one of important reasons affecting the eye health of the aged, so that serious vision damage and even blindness are caused, and the age-related eye health diseases can be killed in a cradle in early stage through timely nutrition intervention.
Tagetes, carrots, pumpkin and the like are recognized as "eye protection golden partner", and are rich in carotenoid bioactive substances such as lutein, zeaxanthin and beta-carotene. The combination of lutein and zeaxanthin can filter harmful blue light, protect eyes from oxidative stress and free radical injury, reduce macula damage, and play roles in maintaining normal vision of retina, preventing senile maculopathy, preventing retinitis pigmentosa, etc.; beta-carotene is absorbed and converted into vitamin A (also known as retinol or anti-xerophthalmia factors) through the small intestine in the human body, and the vitamin A has the function of maintaining normal visual functions in dark places, is beneficial to relieving the influence of ultraviolet rays and high-energy visible light, and simultaneously stabilizes the transportation of lutein and zeaxanthin to eyes and indirectly promotes the health of retina and macular area. The human body cannot synthesize lutein, zeaxanthin and beta-carotene by itself and must be supplemented by food. The existing preparation method of the eye-protecting candy is complex, and has poor taste, low content of eye-protecting core components and low activity.
In order to solve the problems, a preparation method of the Sanhuang eye-protecting candy tablet is particularly important.
Disclosure of Invention
The invention aims to solve the technical problem of providing a preparation method of a Sanhuang eye-protecting candy tablet aiming at the defects of the prior art. The Sanhuang eye-protecting candy tablet product prepared by the method has good taste, easy chewing, high content of eye-protecting core components, good activity, convenient and quick eating and can be used for people with different degrees of uncomfortable symptoms such as dry eyes, eye astringents, eye swelling, eye fatigue, night blindness, mosquito and the like.
In order to solve the technical problems, the invention adopts the following technical scheme: a preparation method of Sanhuang eye-protecting candy pieces, which comprises the following steps:
s1, extracting marigold particles by adopting a subcritical extraction method with R134a as an extraction solvent to obtain a fat-soluble extract rich in provitamin A; enriching and purifying the fat-soluble extract rich in provitamin A by adopting a medium-pressure preparation chromatographic system to obtain eluent rich in provitamin A; concentrating the eluent rich in provitamin A under reduced pressure, and vacuum freeze-drying to obtain provitamin A;
s2, taking the provitamin A obtained in the step S1 as a core material, taking embedding agent and maltodextrin as wall materials, and adding other main materials, other flavoring agents and fillers, and emulsifying, homogenizing and spray-drying to obtain microcapsule powder;
s3, adding the microcapsule powder obtained in the step S2 into a lubricant, and tabletting and forming to obtain the Sanhuang eye-protecting candy tablet.
Preferably, the marigold particles in S1 have a size of 10mm; the subcritical extraction method has the extraction time of 40-60 min, the extraction pressure of 1.0-1.2 MPa, the extraction temperature of 45-50 ℃ and the extraction times of 4 times.
Preferably, the content of provitamin A in the fat-soluble extract rich in provitamin A in S1 is more than or equal to 30%.
Preferably, the enrichment purification of the medium pressure preparative chromatography system described in S1 is: dissolving fat-soluble extract rich in vitamin A and absolute ethyl alcohol according to a mass-volume ratio of 1:5, loading into a chromatographic column, and performing linear gradient elution at a flow rate of 20mL/min, absolute ethyl alcohol as phase A, water as phase B and a detection wavelength of 445nm for 40min, wherein the initial gradient of elution is 10% B, and the elution is carried out for 40min to 90% B; the chromatographic column is Dubhe ODS-C18 medium pressure chromatographic column, and the column temperature of the chromatographic column is 30 ℃.
Preferably, the temperature of the reduced pressure concentration in S1 is 25-40 ℃, the pressure is-0.08 to-0.06 Mpa, and the rotating speed is 20-40 rpm.
Preferably, the homogenizing pressure in S2 is 35-45 MPa; the peristaltic pump of spray drying has a rotating speed of 50rpm, a feeding speed of 10-15 mL/min, an air inlet temperature of 220-230 ℃ and an air outlet temperature of 70-80 ℃.
Preferably, the pressure of the tablet forming in the step S3 is 70-80 KN.
Preferably, the lutein ester content in the Sanhuang eye-protecting candy pieces in the step S3 can reach 10-15.1 mg/g.
Preferably, the consumption of the provitamin A in the S2 is 2.0-2.5 parts by weight, and the other main materials are inulin, carrot powder, pumpkin powder, sea buckthorn fruit powder and blueberry fruit powder; the inulin is prepared from 12.5-14 parts by weight of inulin, 3-4 parts by weight of carrot powder, 4-5 parts by weight of pumpkin powder, 3-4 parts by weight of sea buckthorn fruit powder and 2-3 parts by weight of blueberry fruit powder; the dosage of the maltodextrin is 38-43 parts by weight; the dosage of the other flavoring agents is 21-25 parts by weight, and the other flavoring agents comprise 19-21 parts of sugarless sweetener, 1-2 parts of acidulant and 1-2 parts of aromatic; the total dosage of the filler and the embedding agent is 5-6 parts by weight; the using amount of the lubricant in the step S3 is 1-2 parts by weight.
Compared with the prior art, the invention has the following advantages:
1. the invention adopts a combined technology of subcritical extraction and medium pressure chromatography to separate and purify the active ingredients in the marigold granule raw materials: the extraction solvent directly reaches the interior of the raw material cell for accurate extraction in a high-pressure liquid state, and is converted into a gaseous state to leave an extraction product in a normal pressure state, so that the purity and the safety of the extraction product are ensured; the whole process is carried out in a low-temperature, oxygen-free and airtight environment, so that the decomposition of active ingredients caused by high temperature, oxygen and illumination is effectively avoided.
2. The invention adopts the microcapsule embedding and film coating to carry out two procedures and double embedding on the extract and the tablet, effectively prevents the oxidation, decomposition and inactivation of the eye-protecting effective components in the product by temperature, oxygen and illumination in the carrying and eating processes, prolongs the shelf life of the product, improves the efficacy, and has wider and flexible application scene.
3. The invention adopts marigold, carrot, pumpkin and the like which are recognized as 'eye protection golden partner', is rich in carotenoid bioactive substances such as lutein, zeaxanthin, beta-carotene and the like, and can realize the functions of maintaining normal visual functions, preventing myopia, relieving age-related eye diseases such as age-related macular degeneration, cataract and the like by quenching free radicals, filtering harmful blue light and reducing macular damage.
The technical scheme of the invention is further described in detail through the drawings and the embodiments.
Drawings
FIG. 1 is a graph comparing the near point results of the two-eye set of the human subject before and after using the three-yellow eye-protecting candy pieces in example 2.
Fig. 2 is a graph comparing the results of monocular measurements of the sensitivity of the test person before and after using the tri-yellow eye-protecting candy pieces in example 2.
Fig. 3 is a graph comparing the results of binocular measurement of the sensitivity of the test person before and after using the three-yellow eye-protecting candy sheet in example 2.
Fig. 4 is a graph comparing the results of the relative accommodation measurements of the positive and negative eyes of a human subject before and after using the three-yellow eye-protecting candy pieces in example 2.
Detailed Description
Example 1
The preparation method of the Sanhuang eye-protecting candy tablet comprises the following steps:
s1, extracting marigold particles with the size of 10mm by adopting a subcritical extraction method with R134a as an extraction solvent, wherein the extraction time of the subcritical extraction method is 60min, the extraction pressure is 1.0MPa, the extraction temperature is 47 ℃, and the extraction times are 4 times, so as to obtain a fat-soluble extract rich in provitamin A; enriching and purifying the fat-soluble extract rich in provitamin A by a chromatographic column of a medium-pressure preparation chromatographic system, wherein the enriching and purifying is as follows: dissolving 2g of fat-soluble extract rich in provitamin A with 10mL of absolute ethyl alcohol, loading into Dubhe ODS-C18 medium pressure chromatographic column, eluting with linear gradient of detection wavelength 445nm with absolute ethyl alcohol and water as phase A and phase B at flow rate of 20mL/min at 30deg.C for 40min with initial gradient of 10% B and eluting for 40min to 90% B to obtain provitamin A-rich eluent; concentrating the eluent rich in provitamin A under reduced pressure at 25 ℃, under the pressure of-0.07 Mpa and the rotating speed of 20rpm, wherein the content of solids in the concentrated solution obtained after the reduced pressure concentration is 40%, and obtaining provitamin A after vacuum freeze-drying;
s2, taking the provitamin A obtained in the step S1 as a core material, taking embedding agent and maltodextrin as wall materials, and adding other main materials, other flavoring agents and fillers, and emulsifying by adding water, homogenizing and spray drying to obtain microcapsule powder;
the homogenizing pressure is 35MPa; the content of solid in the mixed solution obtained after emulsification and homogenization is 40 percent; the peristaltic pump of spray drying has the rotating speed of 50rpm, the feeding speed of 13mL/min, the air inlet temperature of 225 ℃ and the air outlet temperature of 75 ℃; the consumption of the provitamin A is 2 parts by weight, and the other main materials are inulin, carrot powder, pumpkin powder, sea buckthorn fruit powder and blueberry fruit powder; the inulin comprises 12.5 parts by weight of inulin, 3 parts by weight of carrot powder, 4 parts by weight of pumpkin powder, 3 parts by weight of sea buckthorn fruit powder and 2 parts by weight of blueberry fruit powder; the dosage of the maltodextrin is 38 parts by weight; the dosage of the other flavoring agents is 21 parts by weight, and the other flavoring agents comprise 19 parts of sugarless sweetener, 1 part of acidulant and 1 part of flavoring agent; the total dosage of the filler and the embedding agent is 5.5 parts by weight; the water consumption of the emulsification is 30% of the total weight of the provitamin A, other main materials, maltodextrin, other flavoring agents, embedding agents and filling agents; the maltodextrin is also used as a flavoring agent;
s3, adding the microcapsule powder obtained in the S2 into a lubricant, and tabletting and forming by adopting a tablet press under the condition of 70KN pressure to obtain a Sanhuang eye-protecting candy tablet; the weight portion of the lubricant is 1 portion.
Through detection, the content of provitamin A in the fat-soluble extract rich in provitamin A in S1 is 30.7g/100g, the purity of provitamin A is 86.7g/100g, and the content of lutein ester is 89.5g/100g; the lutein ester content in the Sanhuang eye-protecting candy tablet is 13.4mg/g.
Example 2
The preparation method of the Sanhuang eye-protecting candy tablet comprises the following steps:
s1, extracting marigold particles with the size of 10mm by adopting a subcritical extraction method with R134a as an extraction solvent, wherein the extraction time of the subcritical extraction method is 50min, the extraction pressure is 1.1MPa, the extraction temperature is 50 ℃, and the extraction times are 4 times, so as to obtain a fat-soluble extract rich in provitamin A; enriching and purifying the fat-soluble extract rich in provitamin A by a chromatographic column of a medium-pressure preparation chromatographic system, wherein the enriching and purifying is as follows: dissolving 2g of fat-soluble extract rich in provitamin A with 10mL of absolute ethyl alcohol, loading into Dubhe ODS-C18 medium pressure chromatographic column, eluting with linear gradient of detection wavelength 445nm with absolute ethyl alcohol and water as phase A and phase B at flow rate of 20mL/min at 30deg.C for 40min with initial gradient of 10% B and eluting for 40min to 90% B to obtain provitamin A-rich eluent; concentrating the eluent rich in provitamin A under reduced pressure at 35 ℃ under-0.08 Mpa at 30rpm to obtain concentrated solution with 40% of solid content, and vacuum lyophilizing to obtain provitamin A;
s2, taking the provitamin A obtained in the step S1 as a core material, taking embedding agent and maltodextrin as wall materials, and adding other main materials, flavoring agents and fillers, and emulsifying by adding water, homogenizing and spray drying to obtain microcapsule powder;
the homogenizing pressure is 45MPa; the content of solid in the mixed solution obtained after emulsification and homogenization is 45 percent; the peristaltic pump of spray drying has the rotating speed of 50rpm, the feeding speed of 15mL/min, the air inlet temperature of 230 ℃ and the air outlet temperature of 80 ℃; the consumption of the provitamin A is 2.2 parts by weight, and the other main materials are inulin, carrot powder, pumpkin powder, sea buckthorn fruit powder and blueberry fruit powder; 13.5 parts of inulin, 3 parts of carrot powder, 4 parts of pumpkin powder, 3 parts of sea buckthorn fruit powder and 2 parts of blueberry fruit powder in parts by weight; the maltodextrin is used in an amount of 40 parts by weight, the other flavoring agents are used in an amount of 22.3 parts by weight, and the other flavoring agents comprise 19 parts of sugarless sweetener, 1.8 parts of acidulant and 1.5 parts of flavoring agent; the total dosage of the filler and the embedding agent is 5 parts by weight; the water consumption of the emulsification is 35% of the total weight of the provitamin A, other main materials, maltodextrin, other flavoring agents, embedding agents and filling agents; the maltodextrin is also used as a flavoring agent;
s3, adding the microcapsule powder obtained in the S2 into a lubricant, and tabletting and forming by adopting a tablet press under the condition of 75KN pressure to obtain a Sanhuang eye-protecting candy tablet; the weight portion of the lubricant is 1.3 portions.
Through detection, the content of provitamin A in the fat-soluble extract rich in provitamin A in S1 is 32.3g/100g, the purity of provitamin A is 88.5g/100g, and the content of lutein ester is 91.3g/100g; the lutein ester content in the Sanhuang eye-protecting candy tablet is 15.1mg/g.
The three-yellow eye-protecting candy tablet prepared in the embodiment is used as a sample for crowd trial feeding experiments, and the actual effect of the product on relieving asthenopia and improving the eye health condition is evaluated.
Screening of the tested group: 30 subjects and testers with eye fatigue who voluntarily participated in the project study were selected by means of a questionnaire.
Dosage and method of use of the sample: the sample administration method comprises orally taking two tablets each day for 4 weeks.
Efficacy criterion:
(1) In Table 1 below, 3 of 8 symptoms of eye distention, eye ache, photophobia, blurred vision, dry eyes, foreign body sensation, lacrimation and general discomfort (decrease in symptom integral) were improved, and the improvement of the symptoms was judged without deterioration of the other symptoms. The effective rate (%) of symptom improvement was calculated as the number of symptom improvement cases/the number of test cases×100%.
TABLE 1 method for judging asthenopia symptoms
Note that: "even feel" means 1-2 times/2 days; the term "sometimes" means 1 to 3 times/day; "frequent" means > 3 times/day.
Results of crowd feeding questionnaire:
after the Sanhuang eye-protecting candy pieces are taken for 4 weeks continuously, the symptom improvement conditions of the tested population are counted, the number of symptom improvement cases is 25, the effective rate of symptom improvement reaches 83.3%, and the Sanhuang eye-protecting candy pieces prepared by the embodiment have obvious effect of improving asthenopia.
For details, see table 2 below, the eye fatigue related data were tested and analyzed in a hospital in lanzhou, gansu, before the test and after the 4 week test.
Table 2 eye test items
Experimental results of crowd feeding trial:
visual ability analysis
a near point of binocular collection
The measurement results of the near points of the two-eye sets before and after the three-yellow eye-protection candy pieces are shown in fig. 1, the near points of the two-eye sets before the three-yellow eye-protection candy pieces are 14.12, the prompt set is insufficient, the average value of the near points of the two-eye sets after 4 weeks of use is 14.08, the three-yellow eye-protection candy pieces are reduced by 0.04 compared with the three-yellow eye-protection candy pieces before use, and the adjustment capability of test eyes after use is slightly enhanced.
b adjusting sensitivity
The results of monocular measurement of the adjustment sensitivity before and after the three yellow eye-protecting candy pieces are shown in fig. 2, the average value of the monocular measurement of the adjustment sensitivity after the eye-protecting candy pieces are used for 4 weeks is 14.58, the adjustment sensitivity is improved by 3.37 compared with that before the use, and the monocular adjustment sensitivity is obviously enhanced after the use (P < 0.001).
The results of the binocular measurement of the adjustment sensitivity of the three yellow eye-protecting candy pieces before and after the test person uses the three yellow eye-protecting candy pieces are shown in fig. 3, the average value of the monocular measurement of the adjustment sensitivity of the eye-protecting candy pieces after 4 weeks is 14.12, the adjustment sensitivity is improved by 1.7 compared with that before the test person uses the eye-protecting candy pieces, and the adjustment sensitivity of the eyes is obviously enhanced after the test person uses the eye-protecting candy pieces (P < 0.001).
c relative accommodation of eyes
The results of the positive and negative binocular relative adjustment measurements before and after the test person used the three-yellow eye-protection candy pieces are shown in fig. 4, and the difference between the binocular relative adjustment measurements increases after the eye-protection candy pieces are used for 4 weeks, showing the enhancement of the adjustment (reserve) ability in the second test.
d amount of tear secretion
The test results show that the tear secretion of most of the subjects increases after the test is finished, which suggests that the tear secretion function is enhanced. Wherein, the secretion of tears can not be measured due to the shrinkage of eyeballs of the right eyes of 1 person, and 23 persons with increased secretion of the right tear eyes in 29 persons occupy 79.3% of the number of effective tested persons; 25 people with increased lacrimal secretion in left eye account for 83.3% of total subjects. The three-yellow eye-protecting candy tablet prepared by the embodiment has obvious regulating effect on preventing xerophthalmia symptoms caused by asthenopia.
In conclusion, according to a test feeding experiment, the Sanhuang eye-protecting candy tablet prepared by the embodiment has a certain eye-protecting effect.
Example 3
The preparation method of the Sanhuang eye-protecting candy tablet comprises the following steps:
s1, extracting marigold particles with the size of 10mm by adopting a subcritical extraction method with R134a as an extraction solvent, wherein the extraction time of the subcritical extraction method is 40min, the extraction pressure is 1.2MPa, the extraction temperature is 45 ℃, and the extraction times are 4 times, so as to obtain a fat-soluble extract rich in provitamin A; enriching and purifying the fat-soluble extract rich in provitamin A by a chromatographic column of a medium-pressure preparation chromatographic system, wherein the enriching and purifying is as follows: dissolving 2g of fat-soluble extract rich in provitamin A with 10mL of absolute ethyl alcohol, loading into Dubhe ODS-C18 medium pressure chromatographic column, eluting with linear gradient of detection wavelength 445nm with absolute ethyl alcohol and water as phase A and phase B at flow rate of 20mL/min at 30deg.C for 40min with initial gradient of 10% B and eluting for 40min to 90% B to obtain provitamin A-rich eluent; concentrating the eluent rich in provitamin A under reduced pressure at 40 ℃, wherein the pressure is-0.06 Mpa, the rotating speed is 40rpm, the solid content in the concentrated solution obtained after the reduced pressure concentration is 40%, and obtaining provitamin A after vacuum freeze-drying;
s2, taking the provitamin A obtained in the step S1 as a core material, taking embedding agent and maltodextrin as wall materials, and adding other main materials, flavoring agents and fillers, and emulsifying by adding water, homogenizing and spray drying to obtain microcapsule powder;
the homogenizing pressure is 45MPa; the content of solid in the mixed solution obtained after emulsification and homogenization is 35 percent; the peristaltic pump of spray drying has the rotating speed of 50rpm, the feeding speed of 10mL/min, the air inlet temperature of 220 ℃ and the air outlet temperature of 70 ℃; the consumption of the provitamin A is 2.5 parts by weight, and the other main materials are inulin, carrot powder, pumpkin powder, sea buckthorn fruit powder and blueberry fruit powder; 14 parts of inulin, 4 parts of carrot powder, 5 parts of pumpkin powder, 4 parts of sea buckthorn fruit powder and 3 parts of blueberry fruit powder in parts by weight; the maltodextrin is used in an amount of 43 parts by weight, the other flavoring agents are used in an amount of 25 parts by weight, and the other flavoring agents comprise 21 parts of sugarless sweetener, 2 parts of sour agent and 2 parts of aromatic agent; the total dosage of the filler and the embedding agent is 6 parts by weight; the water consumption of the emulsification is 40% of the total weight of the provitamin A, other main materials, maltodextrin, other flavoring agents, embedding agents and filling agents; the maltodextrin is also used as a flavoring agent;
s3, adding the microcapsule powder obtained in the S2 into a lubricant, and tabletting and forming by adopting a tabletting machine under the condition of 80KN pressure to obtain a Sanhuang eye-protecting candy tablet; the weight portion of the lubricant is 2 portions.
According to detection, the content of provitamin A in the fat-soluble extract rich in provitamin A in S1 is 29.7g/100g, the purity of provitamin A is 82.3g/100g, and the content of lutein ester is 82.2g/100g; the lutein ester content in the Sanhuang eye-protecting candy tablet is 12.9mg/g.
The above description is only of the preferred embodiments of the present invention, and is not intended to limit the present invention. Any simple modification, variation and equivalent variation of the above embodiments according to the technical substance of the invention still fall within the scope of the technical solution of the invention.
Claims (9)
1. The preparation method of the Sanhuang eye-protecting candy tablet is characterized by comprising the following steps of:
s1, extracting marigold particles by adopting a subcritical extraction method with R134a as an extraction solvent to obtain a fat-soluble extract rich in provitamin A; enriching and purifying the fat-soluble extract rich in provitamin A by adopting a medium-pressure preparation chromatographic system to obtain eluent rich in provitamin A; concentrating the eluent rich in provitamin A under reduced pressure, and vacuum freeze-drying to obtain provitamin A;
s2, taking the provitamin A obtained in the step S1 as a core material, taking embedding agent and maltodextrin as wall materials, and adding other main materials, other flavoring agents and fillers, and emulsifying, homogenizing and spray-drying to obtain microcapsule powder;
s3, adding the microcapsule powder obtained in the step S2 into a lubricant, and tabletting and forming to obtain the Sanhuang eye-protecting candy tablet.
2. The method for preparing a three-yellow eye-protecting candy sheet according to claim 1, wherein the marigold particles in S1 have a size of 10mm; the subcritical extraction method has the extraction time of 40-60 min, the extraction pressure of 1.0-1.2 MPa, the extraction temperature of 45-50 ℃ and the extraction times of 4 times.
3. The method for preparing a Sanhuang eye-protecting candy according to claim 1, wherein the content of provitamin a in the fat-soluble extract rich in provitamin a in S1 is not less than 30%.
4. The method for preparing a three-yellow eye-protecting candy according to claim 1, wherein the enrichment purification of the medium-pressure preparation chromatography system in S1 is: dissolving fat-soluble extract rich in vitamin A and absolute ethyl alcohol according to a mass-volume ratio of 1:5, loading into a chromatographic column, and performing linear gradient elution at a flow rate of 20mL/min, absolute ethyl alcohol as phase A, water as phase B and a detection wavelength of 445nm for 40min, wherein the initial gradient of elution is 10% B, and the elution is carried out for 40min to 90% B; the chromatographic column is Dubhe ODS-C18 medium pressure chromatographic column, and the column temperature of the chromatographic column is 30 ℃.
5. The method for preparing the Sanhuang eye-protecting candy according to claim 1, wherein the temperature of the decompression concentration in S1 is 25-40 ℃, the pressure is-0.08-0.06 Mpa, and the rotating speed is 20-40 rpm.
6. The method for preparing a Sanhuang eye-protecting candy according to claim 1, wherein the homogenizing pressure in S2 is 35-45 MPa; the peristaltic pump of spray drying has a rotating speed of 50rpm, a feeding speed of 10-15 mL/min, an air inlet temperature of 220-230 ℃ and an air outlet temperature of 70-80 ℃.
7. The method for preparing the three-yellow eye-protecting candy according to claim 1, wherein the pressure of the tabletting molding in the step S3 is 70-80 KN.
8. The preparation method of the Sanhuang eye-protecting candy according to claim 1, wherein the lutein ester content in the Sanhuang eye-protecting candy in S3 can reach 10-15.1 mg/g.
9. The preparation method of the Sanhuang eye-protecting candy tablet according to claim 1, wherein the dosage of the provitamin A in the S2 is 2.0-2.5 parts by weight, and the other main materials are inulin, carrot powder, pumpkin powder, sea buckthorn fruit powder and blueberry fruit powder; the inulin is prepared from 12.5-14 parts by weight of inulin, 3-4 parts by weight of carrot powder, 4-5 parts by weight of pumpkin powder, 3-4 parts by weight of sea buckthorn fruit powder and 2-3 parts by weight of blueberry fruit powder; the dosage of the maltodextrin is 38-43 parts by weight; the dosage of the other flavoring agents is 21-25 parts by weight, and the other flavoring agents comprise 19-21 parts of sugarless sweetener, 1-2 parts of acidulant and 1-2 parts of aromatic; the total dosage of the filler and the embedding agent is 5-6 parts by weight; the using amount of the lubricant in the step S3 is 1-2 parts by weight.
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