CN115887521A - Composition for relieving visual fatigue and preparation method thereof - Google Patents

Abstract

The invention discloses a composition for relieving visual fatigue and a preparation method thereof, which relate to the technical field of eye health care and are prepared from the following components: cowberry fruit extract, zinc, xanthophyll, and vitamins; the invention has simple preparation process, is convenient to take by adopting a soft capsule mode, can greatly relieve eye fatigue and eye puckery caused by long-time computer operation for people after being taken frequently, enables people to clear away the heart fire and improve eyesight, protects eyes and refreshes, and particularly aims at relieving symptoms of eye dryness, eye puckery, eye swelling and pain and the like.

Description

Composition for relieving visual fatigue and preparation method thereof

Technical Field

The invention belongs to the technical field of eye health care, and particularly relates to a composition for relieving visual fatigue and a preparation method thereof.

Background

With the development of science and technology and the improvement of economic level since the 21 st century, the wide use of electronic products and the eye use time of school-age children are greatly increased. An analysis involving 145 studies in foreign countries predicted that global myopia rates in 2050 would account for 49.8% of the total population in the world to 47.58 billion.

Asthenopia is a syndrome in which organic factors of the eye or the whole body are interlaced with mental and psychological factors, and is a group of symptoms which are manifested as visual disturbance, eye discomfort and general symptoms after eyes are used, so that the visual operation cannot be normally performed, and therefore, the asthenopia syndrome is also commonly called as asthenopia syndrome in clinic.

After long-time use of eyes, the eyes are continuously tired, and the vision is gradually deteriorated.

The invention relates to a composition for relieving asthenopia, in particular to a traditional Chinese medicine compound composition for treating myopia and relieving asthenopia and a preparation method thereof, belonging to the prior art, the application number 201110401319.1 is prepared by processing the following traditional Chinese medicine raw materials: 100-500 parts of green boxes; mulberry fruit 100-500 weight portions; 100-500 parts of wolfberry fruit; 100-500 parts of cassia seed; 100 to 500 portions of chrysanthemum, but the composition has limited effect on relieving eye fatigue.

With the increase of eye protection requirements in recent years and further research on eye protection products, further improvement on the prior art is needed to provide an eye protection product with better effect.

Disclosure of Invention

The invention aims to provide a composition for relieving visual fatigue and a preparation method thereof, and aims to overcome the defects in the prior art.

The technical scheme adopted by the invention is as follows:

the composition for relieving the visual fatigue is prepared from the following components in parts by weight: 6.2 to 1550 parts of cowberry extract, 0.4 to 100 parts of zinc, 0.2 to 50 parts of lutein and 2.2 to 550 parts of vitamins.

As a further technical scheme: the vitamins include: vitamin A, vitamin C, vitamin E;

specifically, 0.2 to 50 parts of vitamin A, 1.6 to 400 parts of vitamin C and 0.4 to 100 parts of vitamin E.

A preparation method of a composition for relieving visual fatigue comprises the following steps:

(1) Weighing the materials in parts by weight

(2) Sequentially adding the substances into the oil-wax mixture, and stirring for 30-40min to obtain a mixed liquid;

(3) And pelleting and drying the mixed liquid to prepare the soft capsule.

The visual fatigue is caused by long-time improper eye use, such as short-distance visual objects, high tension, flicker, high brightness, low brightness, overuse of eyes, long-time wearing of contact lenses and the like, and then blurred vision, eye swelling, dryness, lacrimation, eye socket ache and other eye symptoms even develop into a syndrome of general maladaptation, such as headache, dizziness, nausea, dysphoria, hypodynamia and the like.

The invention has the advantages that by introducing a certain amount of anthocyanin (derived from cowberry fruit extract), the anthocyanin can have excellent improvement effect on retina.

The synergistic effect of vitamin A and zinc, lutein and anthocyanin has obvious improvement and improvement effects on the aspect of protecting retina and activity of photoreceptor cells, and plays an effective promoting role in relieving visual fatigue.

The combination of anthocyanin, vitamin C, vitamin E and the like can improve the visual nerve excitability.

Has the advantages that:

the invention has simple preparation process, is convenient to take by adopting a soft capsule mode, can greatly relieve eye fatigue and eye puckery caused by long-time computer operation for people after being taken frequently, enables people to clear away the heart fire and improve eyesight, protects eyes and refreshes, and particularly aims at relieving symptoms such as dry eyes, eye puckery eyes, eye swelling and pain and the like.

The composition of the invention can jointly care eyes from three defense lines of crystalline lens, retina and optic nerve and relieve visual fatigue.

Drawings

FIG. 1 is a bar graph of the improvement in fatigue relief for each group of compositions.

Detailed Description

Example 1

The composition for relieving the visual fatigue is prepared from the following components in parts by weight: 31 parts of cowberry fruit extract, 2 parts of zinc, 1 part of lutein and 11 parts of vitamin.

The vitamins are: 1 part of vitamin A, 8 parts of vitamin C and 2 parts of vitamin E. A method for preparing a composition for relieving visual fatigue, comprising the following steps:

(1) Weighing the materials in parts by weight;

(2) Sequentially adding the substances into the oil-wax mixture, and stirring for 30-40min to obtain a mixed liquid;

(3) And pelleting and drying the mixed liquid to prepare the soft capsule.

Example 2

The composition for relieving the visual fatigue is prepared from the following components in parts by weight: 31 parts of cowberry fruit extract, 2 parts of zinc, 0.1 part of lutein and 11 parts of vitamin.

The vitamins are: 1 part of vitamin A, 8 parts of vitamin C and 2 parts of vitamin E. A method for preparing a composition for relieving visual fatigue, comprising the following steps:

(1) Weighing the materials in parts by weight;

(2) Sequentially adding the substances into the oil-wax mixture, and stirring for 30-40min to obtain a mixed liquid;

(3) And pelleting and drying the mixed liquid to prepare the soft capsule.

Example 3

The composition for relieving the visual fatigue is prepared from the following components in parts by weight: 31 parts of cowberry fruit extract, 2 parts of zinc, 10 parts of lutein and 11 parts of vitamin.

The vitamins are: 1 part of vitamin A, 8 parts of vitamin C and 2 parts of vitamin E. A method for preparing a composition for relieving visual fatigue, comprising the following steps:

(1) Weighing the materials in parts by weight;

(2) Sequentially adding the substances into the oil-wax mixture, and stirring for 30-40min to obtain a mixed liquid;

(3) And pelleting and drying the mixed liquid to prepare the soft capsule.

Comparative example 1: the difference from example 1 is that no bilberry extract is added;

comparative example 2: the difference from example 1 is that no lutein is added;

1. acute toxicity test

The maximum tolerated dose test was followed:

20 SPF grade ICR mice with half male and female bodies and 20-24g body mass are taken and randomly divided into 6 groups, namely a normal control group (giving 0.3mL/10g of normal saline) and an administration group (giving the same amount of medicine), and each group of mice is subjected to fasting for 16h before experiment (without limitation of drinking water), gavage for 2 times and interval of 8h. After feeding, each group was observed for general conditions for 20 days and body mass changes, and mice in each group were in good condition, diet was normal and no toxic manifestation was observed.

2. Effect of examples and comparative examples on light-induced asthenopia in rats

1. Grouping animals

Clean SD rats (male) with weight of 250 + -10 g are taken and fed adaptively for 7 days with normal water and food. The groups were randomly divided into 4 groups by body weight, i.e., a normal control group, an example 1 group, a comparative example 2 group, and 10 individuals per group.

2. Method of administration

Irrigating normal control group with distilled water for 3 days; example 1 group gastric lavage the soft capsules of example 1, 3 times a day, one capsule at a time, for 3 consecutive days; comparative example 1 group of gastric gavage comparative example 1 soft capsules, 3 times a day, one capsule at a time, for 3 consecutive days; comparative example 2 group gastric gavage comparative example 2 soft capsules, 3 times a day, one capsule at a time, for 3 consecutive days.

3. Establishment of illumination model

The light source is a 100w incandescent lamp 30cm from the vertical height of the rat, with a light time of 15 min. After the illumination of each group is finished, the state of the eyeball of the rat is observed under a slit lamp.

4. Observation indicator and detection method

4.1 pupil diameter/eyelid opening value

Measuring the pupil diameter and the eyelid opening value of the rat, and calculating the ratio of the pupil diameter and the eyelid opening value, namely the pupil diameter/the eyelid opening value.

TABLE 1

	Pupil/eyelid
		Example 1	0.1658
Comparative example 1	0.2216
		Comparative example 2	0.2039
Normal control group	0.3522

As can be seen from Table 1, the composition for relieving visual fatigue prepared by the present invention has a significant reduction effect on the pupil diameter/eyelid opening value of rats.

3. Evaluation of human body function of each example

Aiming at people who often use eyes, the method comprises the following steps: the population of senior high school students, officials, business engineers and mobile phones staying up at night was randomly selected from 100 of the above population and randomly divided into 4 groups of 25 persons each, wherein the first group of the population took the capsules prepared in example 1, the second group took the capsules prepared in comparative example 1, the third group took the capsules prepared in comparative example 2, and the fourth group did not take any ophthalmic drug related products.

The medicine is taken three times a day, 0.5 g for each time, ten days is a treatment course, and the population is revisited after the second treatment course, and the total three treatment courses are adopted.

3.1 the effective rate judgment standard for symptom improvement is as follows: the symptoms of the eye are 3 improved symptoms of ache of the eye, eye swelling, photophobia, blurred vision, dry eyes, foreign body sensation, lacrimation and general discomfort, and the symptoms are judged to be improved if other symptoms are not worsened. Four symptom improvement cases and four symptom improvement effective rates are calculated. The effective rate (%) for symptom improvement was calculated as the number of symptom improvement cases/number of test food cases × 100. The four groups of symptoms were tested for improved efficacy on statistics.

The comparison table 2 calculates the symptom integral before and after the test feeding of each test feeder, calculates the average integral value of the two groups respectively, and performs statistical test.

TABLE 2 asthenopia symptom determination method (semi-quantitative integral method)

Note: "occasionally" means 1-2 times/2 days; sometimes means 1-3 times per day; by "often" is meant >3 times per day

3.2 criterion for persistence of photopic Vision

Compared with the test group or the test group and the control group, the photopic vision persistence difference is significant (p is less than 0.05), and the improvement of the average photopic vision persistence is more than or equal to 10 percent, which is effective. The overall result judgment standard is as follows:

the two requirements are met, the vision improvement rate is not obviously reduced, and the test object can be judged to have the function of helping to relieve the asthenopia.

3.2.1. Compared with the test group or the test group and the control group, the effective rate of improving symptoms or the difference of total score of symptoms is significant (p is less than 0.05).

3.2.2. Compared with the test group or the test group and the control group, the photopic vision persistence difference is significant (p is less than 0.05), and the average photopic vision persistence is improved by more than or equal to 10%.

The symptom improvement rate was the percentage of the population with symptom improvement in the group, as shown in table 3;

TABLE 3 percent improvement of symptoms

	The improvement rate%
		Example 1	96
Comparative example 1	80
		Comparative example 2	88
Normal control group	40

As can be seen from table 3, the composition for alleviating visual fatigue prepared by the present invention has a significant improvement effect on visual fatigue.

FIG. 1 bar graph of the improvement rate of each group of compositions on fatigue relief.

3.3 Soft capsules were prepared with the formulation of example 1 and the statistics of the eating quality were carried out

3.3.1 test methods: screening 110 adults meeting the test standard, and randomly and blindly dividing the 110 adults into two groups, wherein the test group takes the soft capsules prepared by the component in example 1, and the control group takes placebo soft capsules without eye protecting component; and the tested age, sex, basic vision level, daily eye use condition distribute while grouping, make the tested level of the test food group and contrast group similar, have comparability. The safety indexes and the efficacy indexes are respectively checked and recorded at the beginning and the end of the experiment.

3.3.2 dosage and time taken: orally administered twice daily, 2 capsules (0.25 g/capsule) each, continuously for 30 days, and the control group was administered with an equal amount of placebo on the same frequency.

3.3.3 test results: after 8 cases are rejected according to the standard at the end of the test, 102 persons (51 persons in the test group and 51 persons in the control group) remain, and the conditions of spirit, diet, sleep, defecation and the like of the test subjects in the control group and the test group are not abnormal during the test. Before the test, the heart rate, the blood pressure, the electrocardiogram, the X-ray chest fluoroscopy and the abdominal B-ultrasonic examination of the testee are all within the normal range. The blood routine, blood biochemical index and urine routine examination results before and after the test are also in the normal range.

TABLE 4 photopic vision persistence change before and after the test

Note: * Denotes a comparison of P < 0.01 before and after the self; # indicates a comparison between groups P < 0.01

TABLE 5 variation of effectiveness

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Note: # indicates a comparison between groups P < 0.01

As shown in tables 4 and 5, the total effective rate of the control group and the test group is obviously improved after the test (P is less than 0.01).

Based on example 1, the effect of different proportions of lutein and cranberry extract (examples 2-3) on fatigue-relieving cure rate was compared as shown in table 6.

TABLE 6 improvement Rate Change

Lutein: cowberry fruit extract	1：310	1：31	10：31
				The improvement rate%	88％	96％	91％

As can be seen from table 6, there is a golden ratio between lutein and cranberry extract that has a significantly improved rate, in which lutein: bilberry extract =1: the improvement rate was particularly remarkable at 31 f.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention, and the present invention is not limited to the illustrated embodiments, and all the modifications and equivalents of the embodiments may be made without departing from the spirit of the present invention.

Claims (3)

1. A composition for relieving visual fatigue, comprising: the composition is prepared from the following components in parts by weight: 6.2 to 1550 parts of cowberry extract, 0.4 to 100 parts of zinc, 0.2 to 50 parts of lutein and 2.2 to 550 parts of vitamin.

2. The composition for relieving visual fatigue of claim 1, wherein: the vitamins are: vitamin A, vitamin C, vitamin E;

specifically, 0.2 to 50 parts of vitamin A, 1.6 to 400 parts of vitamin C and 0.4 to 100 parts of vitamin E.

3. The method for preparing a composition for relieving visual fatigue according to claim 1 or 2, wherein: the method comprises the following steps:

(1) Weighing the materials in parts by weight

(2) Sequentially adding the substances into the oil-wax mixture, and stirring for 30-40min to obtain a mixed liquid;

(3) The mixed liquid is pressed into pills and dried to prepare soft capsules.

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