CN116368243A - 复制应激通路剂组合物和用于治疗癌症的方法 - Google Patents

复制应激通路剂组合物和用于治疗癌症的方法 Download PDF

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CN116368243A
CN116368243A CN202180069281.4A CN202180069281A CN116368243A CN 116368243 A CN116368243 A CN 116368243A CN 202180069281 A CN202180069281 A CN 202180069281A CN 116368243 A CN116368243 A CN 116368243A
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ecdna
tumor
cells
cancer
treatment
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克里斯蒂安·哈西格
莱恩·汉森
斯内扎娜·米卢蒂诺维奇
杰森·克里斯蒂安森
扎迦利·霍恩比
苏希尔·乔杜里
安东尼·赛莱斯特
克利斯登·特纳
迪普提·威尔金森
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Boundless Bio Inc
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Boundless Bio Inc
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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CN202180069281.4A 2020-08-12 2021-08-11 复制应激通路剂组合物和用于治疗癌症的方法 Pending CN116368243A (zh)

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US202063064555P 2020-08-12 2020-08-12
US63/064,555 2020-08-12
US202163168120P 2021-03-30 2021-03-30
US63/168,120 2021-03-30
PCT/US2021/045556 WO2022035970A1 (en) 2020-08-12 2021-08-11 Replication stress pathway agent compositions and methods for treating cancer

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US (3) US11547711B2 (https=)
EP (1) EP4196614A4 (https=)
JP (1) JP2023537600A (https=)
KR (1) KR20230098134A (https=)
CN (1) CN116368243A (https=)
AU (1) AU2021325905A1 (https=)
BR (1) BR112023002453A2 (https=)
CA (1) CA3187760A1 (https=)
MX (1) MX2023001717A (https=)
TW (1) TW202221118A (https=)
WO (1) WO2022035970A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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CN116083576A (zh) * 2022-12-07 2023-05-09 上海市临床检验中心 一种基于CRISPR/Cas12a的KRAS热点基因突变检测系统和方法

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AU2021325905A1 (en) 2020-08-12 2023-04-13 Boundless Bio, Inc. Replication stress pathway agent compositions and methods for treating cancer
EP4278185A1 (en) * 2021-01-18 2023-11-22 GBG Forschungs GmbH Method for predicting the response to cdk4/6 inhibitor therapy in cancer patients
CA3219348A1 (en) 2021-05-27 2022-12-01 Anthony B. Pinkerton Checkpoint kinase 1 (chk1) inhibitors and uses thereof
CN114835640B (zh) * 2022-05-24 2024-02-13 中国药科大学 成纤维细胞生长因子受体抑制剂、制备方法及应用
EP4587026A1 (en) * 2022-09-15 2025-07-23 Recurium IP Holdings, LLC Combinations
WO2025049814A2 (en) * 2023-09-01 2025-03-06 Boundless Bio, Inc. Ribonucleotide reductase (rnr) compositions and methods of use
WO2025184572A1 (en) * 2024-03-01 2025-09-04 Zeno Management, Inc. Wee1 inhibitor combination therapy

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JPS567007A (en) 1979-06-29 1981-01-24 Toshiba Corp Coating film thickness measuring apparatus
US12559789B2 (en) * 2017-01-20 2026-02-24 The Jackson Laboratory Method of targeting patient-specific oncogenes in extrachromosomal DNA to treat glioblastoma
EP3609884A4 (en) * 2017-04-10 2021-01-06 Sierra Oncology, Inc. CHK1 (SRA737) / PAPI COMBINATION METHOD FOR INHIBITION OF TUMOR GROWTH
US11193164B2 (en) * 2017-05-24 2021-12-07 The Regents Of The University Of California Methods of diagnosing and treating cancer targeting extrachromosomal DNA
CA3065803A1 (en) * 2017-06-01 2018-12-06 Sierra Oncology, Inc. Biomarkers and patient selection strategies
US20210047693A1 (en) * 2017-11-15 2021-02-18 The Regents Of The University Of California Methods of treating extrachromosomal dna expressing cancers
CA3092079A1 (en) * 2018-02-26 2019-08-29 Sierra Oncology, Inc. Methods of treatment of cancer comprising chk1 inhibitors
WO2020123530A1 (en) * 2018-12-10 2020-06-18 The Regents Of The University Of California Compositions and methods for modulating transcriptional activity of amplified oncogenes contained on extrachromosomal dna
EP3966323A4 (en) * 2019-05-06 2024-04-24 The Regents Of The University Of Michigan TARGETED THERAPY
AU2021325905A1 (en) * 2020-08-12 2023-04-13 Boundless Bio, Inc. Replication stress pathway agent compositions and methods for treating cancer
CA3219348A1 (en) 2021-05-27 2022-12-01 Anthony B. Pinkerton Checkpoint kinase 1 (chk1) inhibitors and uses thereof
IL311458A (en) 2021-09-17 2024-05-01 Boundless Bio Inc Cyclic sulfonamide ribonucleotide reductase (rnr) inhibitors and uses thereof
EP4402134A4 (en) 2021-09-17 2025-10-15 Boundless Bio Inc SULFONAMIDE RIBONUCLEOTIDE REDUCTASE (RNR) INHIBITORS AND THEIR USES
US20230272485A1 (en) 2022-02-16 2023-08-31 Boundless Bio, Inc. Replication stress pathway agent compositions and methods for treating cancer

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116083576A (zh) * 2022-12-07 2023-05-09 上海市临床检验中心 一种基于CRISPR/Cas12a的KRAS热点基因突变检测系统和方法
CN116083576B (zh) * 2022-12-07 2024-01-30 上海市临床检验中心 一种基于CRISPR/Cas12a的KRAS热点基因突变检测系统和方法

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US11547711B2 (en) 2023-01-10
US20220143022A1 (en) 2022-05-12
KR20230098134A (ko) 2023-07-03
US11642345B2 (en) 2023-05-09
TW202221118A (zh) 2022-06-01
US20230248728A1 (en) 2023-08-10
US20230078903A1 (en) 2023-03-16
BR112023002453A2 (pt) 2023-05-02
JP2023537600A (ja) 2023-09-04
EP4196614A4 (en) 2024-12-18
AU2021325905A1 (en) 2023-04-13
MX2023001717A (es) 2023-04-13
EP4196614A1 (en) 2023-06-21
US12246017B2 (en) 2025-03-11
WO2022035970A1 (en) 2022-02-17
CA3187760A1 (en) 2022-02-17

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