CN116350553A - Herbal alopecia preventing essence and preparation method thereof - Google Patents

Abstract

The invention provides herbal alopecia preventing essence, which comprises, by mass, 0.27-11.10% of plant extracts, 0.26-6.10% of nutrient elements, 1.51-21.00% of moisturizers, and the balance of water; the plant extract comprises extract of herba Apocyni Veneti Hu Suogen, carthami flos extract, radix Codonopsis Lanceolatae extract, radix Angelicae sinensis extract, rhizoma Ligustici Chuanxiong root extract, olibanum extract, myrrha extract, glycyrrhrizae radix extract, herba Verbenae extract, and oleum Lavandula Angustifolia. The invention is prepared by combining natural herbal plant extracts as main efficacy raw materials with biotechnology and performing multi-disciplinary cross research, and has mild effect on scalp, small irritation and high safety; through the mutual synergistic effect of herbal extract, vitamin B complex, hydrolyzed collagen, biological polypeptide and other nutrients, the hair and skin blood circulation is promoted, scalp nutrition is supplemented, scalp microenvironment is improved, and scalp maintains good growth state, so that alopecia is effectively prevented.

Description

Herbal alopecia preventing essence and preparation method thereof

Technical Field

The invention relates to herbal alopecia preventing essence and a preparation method thereof.

Background

In the past, hair plays an important role in the instrument of the appearance of a human body, and meanwhile, from the perspective of traditional Chinese medicine, hair is also an important index of the health condition of the human body. Hair grows from subcutaneous hair follicles of the head, and the hair growth has periodicity, i.e., it is divided into a growing period, a retrograde period and a resting period, and the hair in the growing period accounts for about 85% of all the hair, and the hair grows by 0.27-0.4 mm per day. The growing period of the hair is 2-6 years, and after entering the retreating period, the hair bulb at the lower part of the hair follicle including the hair growing part starts to shrink. Hair does not grow and becomes loose and is easy to fall off; hair in the retrograde phase accounts for about 1%; in telogen phase, hair follicle lower part is completely atrophic, hair falls off, and hair in telogen phase accounts for about 14%; the resting period lasts for 3-6 months, and then the hair follicle is grown into the growing period and a new hair grows. In recent years, along with the acceleration of the life rhythm, people often overtime and stay up with high life pressure and irregular life, so that health problems are caused, hair quality is affected, and the problems of poor hair quality, dryness, easy falling and the like are often caused. The number of patients with alopecia increases year by year and tends to be younger, and the proportion of men aged 20 to 40 years has a problem of alopecia as high as 40% or more.

The root cause of alopecia is ecological damage of scalp, pore blockage, atrophy and degeneration of hair follicle, and cell atrophy and even necrosis in hair follicle caused by excessive secretion of grease, blockage of hair pore and the like, so that the hair cannot absorb nutrients of surrounding hair, and hair does not grow any more. Under normal conditions, hair papilla in hair follicle has abundant capillary vessels, which can absorb nutrients necessary for hair growth from blood, and ensure normal hair growth. The hair falls off by metabolism by about 50-100 pieces per day, but the whole quantity of the hair is not affected. However, the normal growth environment of the hair is destroyed due to the excessive secretion of sebaceous glands, pore blockage and the like, so that the hair cannot grow normally, and phenomena such as alopecia, hair breakage and the like can occur.

At present, the drugs for treating alopecia and promoting hair growth on the market are more and messy, and the research on the cause of alopecia is not thorough, so that the existing drugs for stopping alopecia and promoting hair growth can not treat both principal and secondary aspect of disease, and the drugs are high in price, large in irritation to scalp, unsatisfactory in effect and side effects. How to obtain a natural mild product for preventing alopecia is a technical problem which needs to be solved in the current field.

Disclosure of Invention

The invention aims to overcome the defects of the prior art, provides herbal alopecia preventing essence and a preparation method thereof, and provides a safe, effective and stable alopecia preventing product.

In order to solve the technical problems, the invention adopts the following technical scheme: an herbal alopecia preventing essence comprises, by mass, 0.27-11.10% of plant extract, 0.26-6.10% of nutrient elements, 1.51-21.00% of humectant, and the balance of water;

the plant extract comprises extract of herba Apocyni Veneti Hu Suogen, carthami flos extract, radix Codonopsis Lanceolatae extract, radix Angelicae sinensis extract, rhizoma Ligustici Chuanxiong root extract, olibanum extract, myrrha extract, glycyrrhrizae radix extract, herba Verbenae extract, and oleum Lavandula Angustifolia.

Further, the plant extract comprises, by mass, 0.1-2% of a tooth petal delay Hu Suogen extract, 0.1-2% of a safflower extract, 0.01-1% of a radix codonopsis pilosulae root extract, 0.01-1% of a angelica sinensis extract, 0.01-1% of a ligusticum wallichii root extract, 0.01-1% of a olibanum extract, 0.01-1% of a myrrh extract, 0.01-1% of a licorice extract, 0.01-1% of a verbena extract and 0.001-0.1% of lavender oil.

Further, the nutrient elements comprise, by mass, 0.1-2% of sodium hyaluronate, 0.05-1% of vitamin E,0.1-2% of palmitoyl pentapeptide-4, 0.01-1% of mannans and 0.001-0.1% of vitamin B complex.

Further, the vitamin B complex comprises biotin, folic acid, vitamin B12, vitamin B3, pantothenic acid, vitamin B6, vitamin B2, vitamin B1 and yeast polypeptides.

Further, the humectant comprises 1-10% of butanediol, 0.1-2% of polyglutamic acid, 0.1-2% of hydrolyzed micronucleus, 0.01-1% of hydrolyzed collagen, 0.1-2% of ascorbic acid, 0.1-2% of glycerol and 0.1-2% of triethanolamine by mass fraction.

Further, the paint also comprises 0.1-2% of thickener by mass, wherein the thickener is carbomer.

Further, the anti-corrosion agent comprises 0.1-2% of anti-corrosion agent by mass, wherein the anti-corrosion agent is p-hydroxyacetophenone.

Further, the preparation method of the herbal alopecia preventing essence comprises the following steps:

s1, adding required purified water into a preparation tank, pouring weighed A-phase raw materials into the preparation tank, uniformly stirring, heating the prepared solution to above 70 ℃, and preserving heat for 30min; the A phase raw material comprises carbomer;

s2, gradually cooling, sequentially pouring the weighed B-phase raw materials, the weighed C-phase raw materials and the balance of purified water, and uniformly stirring;

the B phase raw materials comprise butanediol, sodium hyaluronate, p-hydroxyacetophenone, polyglutamic acid, hydrolyzed sclerotium rolfsii and vitamin E;

the C phase material comprises tooth petal Hu Suogen extract, carthami flos extract, radix Codonopsis Lanceolatae extract, radix Angelicae sinensis extract, rhizoma Ligustici Chuanxiong root extract, olibanum extract, myrrha extract, glycyrrhrizae radix extract, and herba Verbenae extract;

s3, further cooling, sequentially pouring the weighed D-phase raw materials and the weighed E-phase raw materials, uniformly stirring, packaging and sealing to obtain a herbal alopecia-preventing essence finished product with a alopecia-preventing effect;

the phase D comprises hydrolyzed collagen, palmitoyl pentapeptide-4, ascorbic acid, glycerol, mannans and vitamin B complex;

the E phase comprises triethanolamine and lavender oil.

Compared with the prior art, the invention has the beneficial effects that: the herbal extract is used as a main efficacy raw material and is combined with biotechnology, and the hair tonic is prepared through multi-disciplinary cross research, and has the advantages of mild effect on scalp, small irritation and high safety; through the synergistic interaction of the plant extract, the vitamin B complex, the hydrolyzed collagen, the biological polypeptide and other nutrients, the blood circulation of the head skin is promoted, the nutrition of the scalp is supplemented, the microenvironment of the scalp is improved, and the scalp is kept in a good growth state, so that the alopecia is effectively prevented.

Detailed Description

It is to be understood that, according to the technical solution of the present invention, those skilled in the art may propose various alternative structural modes and implementation modes without changing the true spirit of the present invention. Accordingly, the following detailed description is merely illustrative of the invention and should not be taken as an exhaustive or limiting example of the invention.

A herbal baldness-preventing essence consists of purified water, an A phase, a B phase, a C phase, a D phase and an E phase, wherein the components and the weight ratio thereof are as follows:

the principle of the invention is as follows:

angelica sinensis extract: can dilate skin capillary vessel, promote blood circulation, promote hair growth, and nourish hair; can promote blood circulation and enrich blood, and can improve the conditions of hair loss, dark yellow color and the like caused by deficiency of qi and blood; rich in trace elements, and can nourish skin and prevent roughness.

Efficacy of the Boswellia carterii extract: has remarkable anti-inflammatory, blood circulation promoting and blood stasis removing effects;

efficacy effect of myrrh extract: has effects in promoting blood circulation, dispelling blood stasis, relieving inflammation and pain, resisting bacteria, relieving swelling, and promoting granulation;

efficacy of safflower extract: has effects of relieving inflammation, promoting blood circulation, dredging channels, removing blood stasis, and relieving pain;

tooth clack delay Hu Suogen extract: has effects of promoting blood circulation, dispelling blood stasis, activating qi-flowing, relieving pain, and tranquilizing.

Ligusticum wallichii root extract: has effects of promoting blood circulation, activating qi-flowing, dispelling pathogenic wind, and relieving pain.

Radix codonopsis pilosulae root extract: contains sterol, radix Codonopsis glycoside and alkaloid, has effects of invigorating spleen and replenishing qi, invigorating spleen and replenishing lung, and can be used for treating deficiency of both qi and blood, and regulating skin.

Efficacy of licorice extract: has effects of invigorating spleen, replenishing qi, clearing heat, detoxicating, eliminating phlegm, relieving cough, relieving spasm, relieving pain, and harmonizing the medicines.

Vervain extract: has effects in relieving inflammation and pain, stopping bleeding, and inhibiting bacteria.

Lavender oil: has antibacterial and antiinflammatory effects.

The angelica sinensis extract is a monarch drug in the formula, plays a main treatment role, can dilate skin capillaries, quickens blood circulation, and has the effects of promoting hair growth and nourishing hair; the frankincense extract, the myrrh extract, the safflower extract, the tooth petal delay Hu Suogen extract and the ligusticum wallichii root extract are ministerial drugs in the formula and assist the monarch drugs to play a role; the radix codonopsis pilosulae root extract is used as an adjuvant drug in the formula and is used for assisting monarch and ministerial drugs in treating main symptoms and treating concurrent symptoms; the licorice extract, the verbena extract and the lavender oil are used as guiding drugs in the formula, diminishing inflammation, sterilizing, improving the scalp ecology and guiding the drugs to exert the maximum efficacy.

The invention organically combines the raw materials, has reasonable formula, plays a synergistic effect well, promotes scalp blood circulation, inhibits bacteria and resists inflammation, simultaneously permeates various nutrient substances and moisturizing components into skin tissues, improves the environment ecology of the skin of the head, supplements scalp nutrition, and enables the scalp to keep a good growth state, thereby playing the role of preventing alopecia.

The preparation method comprises the following steps:

s1, weighing all required raw materials according to a formula;

s2, adding the required purified water amount into a preparation tank, pouring the weighed A-phase raw materials into the preparation tank, covering a preparation tank cover, uniformly stirring, heating the preparation solution to above 70 ℃, and preserving heat for 30 minutes;

s3, gradually cooling, sequentially pouring the weighed B-phase raw materials and C-phase raw materials, covering a prepared tank cover, and uniformly stirring; pouring the required residual purified water and uniformly stirring;

s4, cooling, pouring the weighed D-phase raw materials, uniformly stirring, pouring the weighed E-phase raw materials, covering a preparation tank cover, and uniformly stirring;

s5, packaging and sealing to obtain the herbal alopecia preventing essence product with the alopecia preventing effect.

The technical effects of the present application are further described below with reference to examples.

Example 1

A preparation method of herbal anti-alopecia essence comprises the following steps:

s1, adding required purified water into a preparation tank, pouring 0.1% carbomer which is weighed into the preparation tank, uniformly stirring, heating the prepared solution to above 70 ℃, and preserving heat for 30min;

s2, gradually cooling, sequentially pouring 1% butanediol, 0.1% sodium hyaluronate, 0.1% p-hydroxyacetophenone, 0.1% polyglutamic acid, 0.1% hydrolyzed sclerotium gum, 0.05% vitamin E,0.1% tooth petal delay Hu Suogen extract, 0.1% safflower extract, 0.01% radix codonopsis extract, 0.01% angelica sinensis extract, 0.01% rhizoma ligustici wallichii root extract, 0.01% frankincense extract, 0.01% myrrh extract, 0.01% licorice extract, 0.01% verbena extract and the balance purified water, and uniformly stirring;

s3, further cooling and sequentially pouring weighed 0.01% of hydrolyzed collagen, 0.1% of palmitoyl pentapeptide-4, 0.1% of ascorbic acid, 0.1% of glycerol, 0.1% of mannans, 0.00% of vitamin B complex, 0.1% of triethanolamine and 0.00% of lavender oil, uniformly stirring, packaging and sealing to obtain the herbal alopecia preventing essence product with alopecia preventing effect.

Example 2

A preparation method of herbal anti-alopecia essence comprises the following steps:

s1, adding required purified water into a preparation tank, pouring 0.56% carbomer which is weighed into the preparation tank, uniformly stirring, heating the prepared solution to above 70 ℃, and preserving heat for 30min;

s2, gradually cooling, sequentially pouring 3.84% butanediol, 0.46% sodium hyaluronate, 0.49% p-hydroxyacetophenone, 0.67% polyglutamic acid, 0.72% hydrolyzed sclerotium gum, 0.34% vitamin E,0.66% tooth petal delay Hu Suogen extract, 0.62% safflower extract, 0.35% radix codonopsis extract, 0.51% angelica sinensis extract, 0.15% rhizoma ligustici wallichii root extract, 0.22% frankincense extract, 0.31% myrrh extract, 0.15% licorice extract, 0.27% verbena extract and the balance of purified water, and uniformly stirring;

s3, further cooling and sequentially pouring weighed 0.36% of hydrolyzed collagen, 0.69% of palmitoyl pentapeptide-4, 0.78% of ascorbic acid, 0.62% of glycerol, 0.27% of mannans, 0.03% of vitamin B complex, 0.67% of triethanolamine and 0.02% of lavender oil, uniformly stirring, packaging and sealing to obtain the herbal alopecia preventing essence product with alopecia preventing effect.

Example 3

A preparation method of herbal anti-alopecia essence comprises the following steps:

s1, adding required purified water into a preparation tank, pouring 1.05% carbomer which is weighed into the preparation tank, uniformly stirring, heating the prepared solution to above 70 ℃, and preserving heat for 30min;

s2, gradually cooling, sequentially pouring 5.5% butanediol, 1.05% sodium hyaluronate, 1.05% p-hydroxyacetophenone, 1.05% polyglutamic acid, 1.05% hydrolyzed sclerotium gum, 0.52% vitamin E,1.05% tooth petal delay Hu Suogen extract, 1.05% safflower extract, 0.51% radix codonopsis extract, 0.52% angelica sinensis extract, 0.48% rhizoma ligustici wallichii root extract, 0.46% frankincense extract, 0.53% myrrh extract, 0.52% licorice extract, 0.47% verbena extract and the balance of purified water, and uniformly stirring;

s3, further cooling and sequentially pouring weighed 0.54% of hydrolyzed collagen, 1.05% of palmitoyl pentapeptide-4, 1.05% of ascorbic acid, 1.05% of glycerol, 0.45% of manna, 0.05% of vitamin B complex, 1.05% of triethanolamine and 0.05% of lavender oil, uniformly stirring, packaging and sealing to obtain the herbal alopecia preventing essence product with alopecia preventing effect.

Example 4

A preparation method of herbal anti-alopecia essence comprises the following steps:

s1, adding required purified water into a preparation tank, pouring 1.52% carbomer which is weighed into the preparation tank, uniformly stirring, heating the prepared solution to above 70 ℃, and preserving heat for 30min;

s2, gradually cooling, sequentially pouring 7.68% butanediol, 1.62% sodium hyaluronate, 1.84% p-hydroxyacetophenone, 1.79% polyglutamic acid, 1.23% hydrolyzed sclerotium gum, 0.76% vitamin E,1.36% tooth petal delay Hu Suogen extract, 1.46% safflower extract, 0.67% radix codonopsis extract, 0.89% angelica sinensis extract, 0.92% rhizoma ligustici wallichii root extract, 0.67% frankincense extract, 0.59% myrrh extract, 0.66% licorice extract, 0.67% verbena extract and the balance of purified water, and uniformly stirring;

s3, further cooling and sequentially pouring weighed 0.75% of hydrolyzed collagen, 1.44% of palmitoyl pentapeptide-4, 1.26% of ascorbic acid, 1.85% of glycerol, 0.51% of manna, 0.08% of vitamin B complex, 1.37% of triethanolamine and 0.09% of lavender oil, uniformly stirring, packaging and sealing to obtain the herbal alopecia preventing essence product with alopecia preventing effect.

Example 5

A preparation method of herbal anti-alopecia essence comprises the following steps:

s1, adding required purified water into a preparation tank, pouring 2% carbomer which is weighed into the preparation tank, uniformly stirring, heating the prepared solution to above 70 ℃, and preserving heat for 30min;

s2, gradually cooling, sequentially pouring 10% butanediol, 2% sodium hyaluronate, 2% p-hydroxyacetophenone, 2% polyglutamic acid, 2% hydrolyzed sclerotium gum, 1% vitamin E,2% tooth petal delay Hu Suogen extract, 2% safflower extract, 1% radix codonopsis extract, 1% angelica sinensis extract, 1% rhizoma ligustici wallichii root extract, 1% frankincense extract, 1% myrrh extract, 1% licorice extract, 1% verbena extract and the balance of purified water, and uniformly stirring;

s3, further cooling and sequentially pouring the weighed 1% hydrolyzed collagen, 2% palmitoyl pentapeptide-4, 2% ascorbic acid, 2% glycerol, 1% manna, 0.1% vitamin B complex, 2% triethanolamine and 0.1% lavender oil into the mixture, uniformly stirring the mixture, packaging the mixture, and sealing the package to obtain the herbal alopecia preventing essence product with the alopecia preventing effect.

Product security

(1) The product of the invention entrusts a third party detection mechanism to carry out security inspection according to cosmetic security technical Specification (2015 edition), and the result is as follows:

(1) and (3) microorganism detection, namely, the total number of colonies, the total number of moulds and yeasts, the heat-resistant coliform group, staphylococcus aureus and pseudomonas aeruginosa meet the requirement of cosmetic safety technical Specification (2015 edition) on microorganism indexes.

(2) Physical and chemical inspection: the test results of mercury, lead, arsenic, cadmium and dioxane meet the requirements of cosmetic safety technical Specification (2015 edition).

(3) Toxicology test:

a. results of multiple skin irritation tests: has no irritation.

b. Skin allergy test results: skin allergies were not seen.

c. Skin phototoxicity test results: no skin phototoxicity was seen.

d. Bacterial back mutation assay results: the test substance showed no mutagenicity with and without S9.

e. In vitro mammalian cell chromosomal aberration test results: negative.

(2) The product of the invention entrusts a third party detection mechanism to carry out human body trial experiments according to cosmetic safety technical Specification (2015 edition), and the results are as follows: a total of 30 subjects completed the test, and skin adverse reaction was found in 0 out of 30 subjects with reference to the human body safety test skin adverse reaction classification standard specified in the 2015 edition of "cosmetic safety technical Specification".

The test results show that the product safety is qualified and has no stimulation to human body safety.

Product availability

The product of the invention entrusts a third party detection mechanism to test the alopecia preventing effect, 60 subjects continue to use the product of the invention for 12 weeks, the alopecia count and the hair density are counted and evaluated, and the change of the tested parts before the use, 4 weeks, 8 weeks and 12 weeks of the use of the product is detected.

The detection result shows that:

(1) after trial of the test product, the improvement degree of the alopecia count of the test product group is obviously better than that of the negative control group (p < 0.05) at each return visit time point;

(2) after trial of the test product, the improvement degree of the local hair density of the test product group has no significant difference (p is more than or equal to 0.05) compared with that of the negative control group at each return visit time point;

(3) after trial of the test product, the overall hair density improvement of the test product group was significantly better than that of the negative control group (p < 0.05) at 12 weeks of return visit after use;

in conclusion, under the test conditions, the test product has the anti-falling effect.

The technical scope of the present invention is not limited to the above description, and those skilled in the art may make various changes and modifications to the above-described embodiments without departing from the technical spirit of the present invention, and these changes and modifications should be included in the scope of the present invention.

Claims (8)

1. The herbal alopecia preventing essence is characterized by comprising, by mass, 0.27-11.10% of plant extracts, 0.26-6.10% of nutrient elements, 1.51-21.00% of moisturizers and the balance of water;

the plant extract comprises extract of herba Apocyni Veneti Hu Suogen, carthami flos extract, radix Codonopsis Lanceolatae extract, radix Angelicae sinensis extract, rhizoma Ligustici Chuanxiong root extract, olibanum extract, myrrha extract, glycyrrhrizae radix extract, herba Verbenae extract, and oleum Lavandula Angustifolia.

2. The herbal anti-baldness essence according to claim 1, wherein the plant extract comprises, in mass fraction, 0.1-2% of a tooth petal extract Hu Suogen extract, 0.1-2% of a safflower extract, 0.01-1% of a radix codonopsitis extract, 0.01-1% of an angelica extract, 0.01-1% of a rhizome of chuanxiong extract, 0.01-1% of a olibanum extract, 0.01-1% of a myrrh extract, 0.01-1% of a licorice extract, 0.01-1% of a verbena extract and 0.001-0.1% of lavender oil.

3. The herbal anti-baldness essence according to claim 1, wherein the nutrient elements comprise, in mass fraction, 0.1-2% sodium hyaluronate, 0.05-1% vitamin E,0.1-2% palmitoyl pentapeptide-4, 0.01-1% mannan and 0.001-0.1% vitamin B complex.

4. The herbal anti-baldness concentrate of claim 3, wherein said vitamin B complex comprises biotin, folic acid, vitamin B12, vitamin B3, pantothenic acid, vitamin B6, vitamin B2, vitamin B1, and yeast polypeptides.

5. The herbal anti-baldness essence according to claim 1, wherein the humectant comprises 1-10% butanediol, 0.1-2% polyglutamic acid, 0.1-2% hydrolyzed sclerotium rolfsii, 0.01-1% hydrolyzed collagen, 0.1-2% ascorbic acid, 0.1-2% glycerol and 0.1-2% triethanolamine by mass fraction.

6. The herbal anti-baldness concentrate of claim 1, further comprising 0.1-2% by mass of a thickener which is carbomer.

7. The herbal anti-baldness essence according to claim 1, further comprising 0.1-2% by mass of a preservative which is p-hydroxyacetophenone.

8. The preparation method of the herbal alopecia preventing essence is characterized by comprising the following steps of:

s1, adding required purified water into a preparation tank, pouring weighed A-phase raw materials into the preparation tank, uniformly stirring, heating the prepared solution to above 70 ℃, and preserving heat for 30min; the A phase raw material comprises carbomer;

s2, gradually cooling, sequentially pouring the weighed B-phase raw materials, the weighed C-phase raw materials and the balance of purified water, and uniformly stirring;

the B phase raw materials comprise butanediol, sodium hyaluronate, p-hydroxyacetophenone, polyglutamic acid, hydrolyzed sclerotium rolfsii and vitamin E;

the C phase material comprises tooth petal Hu Suogen extract, carthami flos extract, radix Codonopsis Lanceolatae extract, radix Angelicae sinensis extract, rhizoma Ligustici Chuanxiong root extract, olibanum extract, myrrha extract, glycyrrhrizae radix extract, and herba Verbenae extract;

s3, further cooling, sequentially pouring the weighed D-phase raw materials and the weighed E-phase raw materials, uniformly stirring, packaging and sealing to obtain a herbal alopecia-preventing essence finished product with a alopecia-preventing effect;

the phase D comprises hydrolyzed collagen, palmitoyl pentapeptide-4, ascorbic acid, glycerol, mannans and vitamin B complex;

the E phase comprises triethanolamine and lavender oil.