CN116350216B - Cochlear acoustic-electric stimulation interference recording and analyzing device - Google Patents
Cochlear acoustic-electric stimulation interference recording and analyzing device Download PDFInfo
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
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- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
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- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
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- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
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Abstract
The invention relates to a cochlear acoustic electrical stimulation interferometry recording and analyzing device, which comprises: the hearing evoked potential detection module is used for generating an acoustic stimulation signal and collecting hearing evoked potentials; the electric evoked potential detection module is connected with the auditory implant prosthesis through an implant interface and is used for generating an electric stimulation signal according to a trigger signal and preset acoustic-electric interval parameters and collecting electric evoked compound action potential and an intra-cochlear electrogram; a synchronous trigger circuit for generating the trigger signal while the acoustic stimulus signal is generated by the acoustic evoked potential monitoring module; and the control module is used for carrying out parameter configuration on the hearing evoked potential detection module and the electric evoked potential detection module and obtaining an acoustic-electric stimulation interference analysis result when the cochlear acoustic-electric combined stimulation is carried out. Compared with the prior art, the method and the device realize accurate recording analysis of the cochlear acoustic-electric stimulation interference, provide basis for setting the personalized optimal combined stimulation strategy, and have the advantages of high reliability and the like.
Description
Technical Field
The invention relates to the technical field of medical appliances, in particular to a cochlear acoustic-electric stimulation interference recording and analyzing device.
Background
Acoustic-electric combined stimulation (Electro-acoustic stimualtion, EAS) is an emerging, advanced mode of action for cochlear implants. The traditional artificial cochlea only applies electric stimulation to the cochlea, and the acoustic-electric combined stimulation simultaneously applies electric stimulation and acoustic stimulation to different parts of the cochlea. The EAS technique is applied to deaf patients with a certain residual hearing, which can lead the patients to obtain better audiological effect than the traditional hearing aid or the simple electric stimulation artificial cochlea, such as better speech recognition rate in noise environment. However, the simultaneous electrical and acoustic stimulation of the cochlea may affect the interactive effects, especially in cases where the time and space separation of the two stimuli is small, thereby affecting the audiological effects of the combined acoustic and electrical stimulation. This effect is hereinafter referred to as cochlear electrical stimulation intervention. At present, detection analysis and research of cochlear acoustic-electric stimulation interference lack special equipment. The device for the interference research of the cochlear acoustic electric stimulation reported in the prior literature does not have precise time sequence and interval regulation, the waveform of the electric stimulation is single and is limited to an electric pulse sequence, and the detection analysis and research requirements cannot be met.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a high-reliability cochlear acoustic-electric stimulation interference recording and analyzing device.
The aim of the invention can be achieved by the following technical scheme:
a cochlear acoustic electrical stimulation interferometry recording analysis apparatus comprising:
the hearing evoked potential detection module is used for generating an acoustic stimulation signal and collecting hearing evoked potentials;
the electric evoked potential detection module is connected with the auditory implant prosthesis through an implant interface and is used for generating an electric stimulation signal according to a trigger signal and preset acoustic-electric interval parameters and collecting electric evoked compound action potential and an intra-cochlear electrogram;
the synchronous trigger circuit is used for connecting the hearing evoked potential detection module and the electric evoked potential detection module, and generating the trigger signal when the hearing evoked potential detection module generates an acoustic stimulation signal;
and the control module is respectively connected with the hearing evoked potential detection module and the electric evoked potential detection module, and is used for carrying out parameter configuration on the hearing evoked potential detection module and the electric evoked potential detection module, and obtaining an acoustic-electric stimulation interference analysis result when the cochlear electric combined stimulation is obtained based on the hearing evoked potential, the electric evoked compound action potential and the cochlear inner ear electrogram.
The device can synchronously apply the acoustic stimulation and the electric stimulation with adjustable different time sequences (front and back sequence and a certain interval) and time intervals (different time intervals of each stimulation) and spaces (different positions of acoustic stimulation and electric stimulation and corresponding to different frequency areas of a basement membrane) to a cochlea through the earphone and the artificial cochlea electrode, and record the auditory evoked potential in the cochlea through the artificial cochlea electrode, and also record the auditory evoked potential through the body surface electrode, thereby realizing the record analysis of the interference of the acoustic electric stimulation of the cochlea.
Further, the hearing-induced potential detection module comprises a hearing-induced potential instrument, a signal amplifier, a filter, an earphone and a recording electrode, wherein the hearing-induced potential instrument is respectively connected with the filter and the earphone, and the filter, the signal amplifier and the recording electrode are sequentially connected.
Further, the recording electrode is a body surface electrode.
Further, the electric evoked potential monitoring module includes:
the trigger end input interface is used for receiving the trigger signal and generating a specific electric stimulation pulse sequence according to parameter configuration of the control module;
and the electric evoked potential data analysis module is used for decoding the potential information transmitted by the implant interface and transmitting the decoded potential information to the control module.
Further, the synchronous trigger circuit comprises two interfaces with electrical structures respectively matched with the hearing evoked potential detection module and the electric evoked potential detection module, and the two interfaces are connected through a wire.
Further, the implant interface includes an adapter, a stimulator, or a radio frequency coil.
Further, the configuration parameters of the auditory evoked potential monitoring module include repetitive stimulation rate, acoustic stimulation intensity, acoustic stimulation time course, and acoustic stimulation frequency.
Further, the configuration parameters of the electric evoked potential monitoring module include repetitive stimulation rate, acoustic-electric interval parameters, and intensity, pulse width, and stimulation pattern of the electric stimulation.
Further, the control module includes a first controller for connection with the auditory evoked potential monitoring module and a second controller for connection with the electrical evoked potential monitoring module.
Further, the control module is further configured to:
and setting an individualized optimal combined stimulation strategy according to the acoustic-electric stimulation interference analysis result.
Compared with the prior art, the invention has the following beneficial effects:
1. the invention can synchronously apply the acoustic stimulation and the electric stimulation with different adjustable time sequences, time intervals and space intervals to the cochlea, record corresponding auditory evoked potential, electric evoked compound action potential and intra-cochlear electric stimulation so as to realize accurate record analysis of the interference of the acoustic stimulation of the cochlea and provide basis for setting an individualized optimal combined stimulation strategy.
2. According to the invention, accurate time sequence and interval regulation and control are carried out on the acoustic stimulation signals and the electric stimulation signals through the synchronous trigger circuit and the preset acoustic-electric interval parameters, so that the acoustic-electric combined stimulation of the cochlea and the intra-cochlear electric map can be freely regulated, and the analysis reliability is improved.
3. The invention adopts the cochlear inner ear electrogram to implant the peri-operative hearing evaluation to the artificial cochlea, and can acquire more accurate and more detailed hearing peripheral evoked potential information.
4. The invention fills the blank in the fields of detection analysis of the acoustic-electric stimulation interference and optimization of the acoustic-electric combined stimulation strategy when the artificial cochlea implements the acoustic-electric combined stimulation of the cochlea, thereby having high industrial value.
Drawings
FIG. 1 is a schematic diagram of the structure of the present invention;
FIG. 2 is a schematic diagram of acoustic and electrical stimulation produced by the present invention;
fig. 3 is a schematic diagram of an auditory evoked potential monitoring module according to an embodiment of the present invention.
Detailed Description
The invention will now be described in detail with reference to the drawings and specific examples. The present embodiment is implemented on the premise of the technical scheme of the present invention, and a detailed implementation manner and a specific operation process are given, but the protection scope of the present invention is not limited to the following examples.
The structures, proportions, sizes, etc. shown in the drawings are shown only in connection with the disclosure of the present invention, and therefore should not be construed as limiting the scope of the invention, since modifications, changes in the proportions, and adjustments of the sizes, which may be made by those skilled in the art, are not intended to limit the scope of the invention, which is defined by the appended claims, without affecting the practice or achievement of the same. Meanwhile, the words "upper", "lower", "left", "right", "front", "rear", "a" and the like are words of description used for convenience only, but are not meant to limit the scope of the invention, and the relative relation is changed or adjusted without substantial change of technical content.
As shown in fig. 1, the embodiment provides a cochlear acoustic-electric stimulation interferometry analysis device, which comprises an auditory evoked potential detection module 1, an electric evoked potential detection module 2, a synchronous trigger circuit 3 and a control module 4, wherein the auditory evoked potential detection module 1 is used for generating an acoustic stimulation signal and collecting auditory evoked potentials; the electric evoked potential monitoring module 2 is connected with the auditory implant prosthesis through an implant interface 5 and is used for generating an electric stimulation signal according to a trigger signal and a preset acoustic-electric interval parameter and collecting an electric Evoked Compound Action Potential (ECAP) and an intra-cochlear-electro-system (ECochG); the synchronous trigger circuit 3 is used for connecting the hearing evoked potential detection module 1 and the electric evoked potential detection module 2, and generating the trigger signal when the hearing evoked potential detection module 1 generates an acoustic stimulation signal; the control module 4 is respectively connected with the hearing-induced potential detection module 1 and the electric-induced potential detection module 2, and is used for carrying out parameter configuration on the hearing-induced potential detection module 1 and the electric-induced potential detection module 2, and obtaining an acoustic-electric stimulation interference analysis result when the cochlear sound and electricity combined stimulation is obtained based on the hearing-induced potential, the electric-induced composite action potential and the cochlear inner ear electrogram. The device generates acoustic stimulation and electric stimulation with a certain time sequence and space through the auditory evoked potential detection module 1 and the electric evoked potential detection module 2, can also utilize the ECAP and ECoc hG detection module to record the near field of the auditory evoked potential of the cochlea, can also utilize the auditory evoked potential and the body surface electrode to realize the far field record analysis of the auditory evoked potential with longer latency, is very favorable for accurately recording and analyzing the space and time interference of the acoustic and electric stimulation, and is further used for scientific research and setting of the individualized acoustic and electric combined stimulation strategy of patients.
In a specific embodiment, as shown in fig. 3, the auditory evoked potential monitoring module 1 includes a commercially available auditory evoked potential meter 101, a signal amplifier 103, a filter 102, an earphone 105 and a recording electrode 104, wherein the auditory evoked potential meter 101 is connected with the filter 102 and the earphone 105 respectively, and the filter 102, the signal amplifier 103 and the recording electrode 104 are connected in sequence, and the accuracy of the auditory evoked potential monitoring module 1 depends on the purchased instrument. In this embodiment, the recording electrode is a body surface electrode, and the auditory evoked potential triggered by acoustic stimulation is recorded by the body surface electrode, so as to realize the recording and analysis of auditory brain stem reaction, middle-length latency and other auditory evoked potentials under the synergistic effect of cochlear acoustic stimulation and electric stimulation. The earphone adopts in-ear earphone, is equipped with 1-2.
In a specific embodiment, the electric evoked potential detection module 2 includes a trigger input interface and an electric evoked potential data analysis module; the former is mainly used for receiving a trigger signal outside the equipment and generating a specific electric stimulation pulse sequence according to the parameter configuration of the second controller B; the latter decodes the potential information transmitted from the implant interface and transmits it to the second controller B. One end of the electric evoked potential detection module 2 receives signals of a radio frequency transmitting coil of the artificial cochlea external speech processor through the radio frequency coil, and the other end outputs signals which are sequentially linked with a lead and an artificial cochlea implant, so that programmed signals are converted into electric stimulation of an implant electrode.
In particular embodiments, implant interfaces are commercially available, including common adaptation materials for cochlear implants, such as adapters, decoding stimulators, radio frequency coils (radio frequency transmit coils, receive coils), and the like. In this embodiment, the implant interface is used for direct connection with a cochlear implant. In other embodiments, it may be coupled to any other form of auditory implant prosthesis via conversion of the implant interface.
In a specific embodiment, the configuration information of the auditory evoked potential monitoring module 1 includes repetitive stimulation rate (7.7/s), acoustic stimulation intensity (0-120 dB SPL, step 5 dB), acoustic stimulation time course (1 ms), acoustic stimulation frequency (125 Hz/250Hz/500Hz/1KHz/2KHz/3KHz/4 KHz), etc. The configuration information of the electric evoked potential monitoring module 2 includes repetitive stimulation rate, acoustic-electric interval parameters, intensity of electric stimulation, pulse width, stimulation pattern, etc.
In this embodiment, the accuracy requirements of the auditory evoked potential monitoring device are: the repeated stimulation rate is 7.7/s, the acoustic stimulation intensity is 0-120dB SPL, the step is 5dB, the acoustic stimulation time interval is 1ms, and the acoustic stimulation frequency is 125Hz/250Hz/500Hz/1KHz/2KHz/3KHz/4KHz. In the embodiment, the ECAP and ECochG detection modules are adopted by the electric evoked potential detection module 2, the required precision is that the acoustic-electric stimulation interval range is 1-130ms, the stepping is 1ms, and the error is less than 50us; the electric stimulation pulse width is fixed to 73us, the pulse amplitude is 0-255CL, and the step is 1CL (the conversion relation between the CL intensity and the current intensity is a current value (μa) =18×100 (CL/255)). The sampling frequency of the electric signal is 20000Hz, and the sampling window is 1.6ms.
In a specific embodiment, the synchronous trigger circuit is composed of two specific interfaces and wires, the two interfaces are respectively connected with the hearing-induced potential detection module and the ECAP & ECochG detection module, and the interface electrical structure is mainly used for adapting to the hearing-induced potential detection module and the ECAP & ECochG detection module and has the characteristics of high anti-interference performance and stability. The synchronous trigger circuit should transmit the trigger signal to the ECAP & ECochG detection module while the acoustic stimulus is being emitted, i.e. the time at which each electrical stimulus starts is controlled by the trigger circuit. As shown in fig. 2, in this embodiment, cochlear sound and electrical stimulation are performed in a certain time sequence and space combination through a synchronous trigger circuit, after the auditory evoked potential detection module 1 releases a single acoustic stimulation, the trigger circuit sends a synchronous trigger signal to the ECAP & ECochG detection module at the same time, so that the ECAP & ECochG detection module starts to release an electrical stimulation signal after the delay according to a set acoustic-electrical interval parameter, so as to ensure that each acoustic stimulation can be coupled with one electrical stimulation at a fixed interval, and can perform repeated sampling after the acoustic stimulation is finished, and the sampling result is overlapped to improve the signal-to-noise ratio so as to obtain a clear electrophysiological waveform. The acousto-electric interval can be adjusted to set the relative front-back positions of the acousto-electric.
In a specific embodiment, the control module 4 comprises a first controller a for connection with an auditory evoked potential monitoring module and a second controller B for connection with an electrical evoked potential monitoring module. The control module 4 may consist of a personal computer equipped with control software adapted to the invention and the necessary software and hardware environment.
In another embodiment, the control module 4 is further configured to: and setting an individualized optimal combined stimulation strategy according to the acoustic-electric stimulation interference analysis result.
The above device can be implanted with a prosthesis via adapted hearing for living organisms of different species, including patients receiving cochlear implants. The embodiment is suitable for the artificial cochlea implant patients with low-frequency residual hearing to dynamically monitor postoperative hearing, in particular to the space-time interference analysis of two types of stimulation during combined acoustic and electric stimulation so as to set an individualized optimal combined stimulation strategy. The device records and analyzes auditory electrophysiological signals of cochlea and auditory nerve under the combined acoustic-electrical stimulation of human or animal inner ear, records the information such as amplitude, threshold value, latency and the like of the neurophysiologic response during single acoustic or electrical stimulation and combined stimulation and the difference between single and combined time, and can be applied to clinical detection and experimental research for interference generated by the acoustic stimulation and the electrical stimulation of the cochlea, thereby optimizing the audiological effect of the acoustic-electrical combined stimulation of a cochlear implant user and also being applied to cochlear function and residual hearing dynamic monitoring of a cochlear implant user with residual hearing.
The foregoing describes in detail preferred embodiments of the present invention. It should be understood that numerous modifications and variations can be made in accordance with the concepts of the invention by one of ordinary skill in the art without undue burden. Therefore, all technical solutions which can be obtained by logic analysis, reasoning or limited experiments based on the prior art by the person skilled in the art according to the inventive concept shall be within the scope of protection defined by the claims.
Claims (7)
1. A cochlear acoustic-electric stimulation interferometry recording and analyzing apparatus, characterized in that the apparatus is a research device adapted for cochlear acoustic-electric stimulation interferometry in the case where the time and space intervals of acoustic-electric stimulation are small, the cochlear acoustic-electric stimulation interferometry being the effect of the interaction of the cochlear electric stimulation and the acoustic stimulation, the space interval being small being the distance between the basal membrane sites on which the acoustic stimulation and the electric stimulation respectively act, the apparatus comprising:
the hearing evoked potential detection module is used for generating an acoustic stimulation signal and collecting hearing evoked potentials;
the electric evoked potential detection module is connected with the auditory implant prosthesis through an implant interface and is used for generating an electric stimulation signal according to a trigger signal and preset acoustic-electric interval parameters and collecting electric evoked compound action potential and an intra-cochlear electrogram;
the synchronous trigger circuit is used for connecting the hearing evoked potential detection module and the electric evoked potential detection module, generating the trigger signal while the hearing evoked potential detection module generates the acoustic stimulation signal so as to synchronously apply adjustable acoustic stimulation and electric stimulation with different time sequences, time courses and space intervals to the cochlea;
the control module is respectively connected with the hearing evoked potential detection module and the electric evoked potential detection module, is used for carrying out parameter configuration on the hearing evoked potential detection module and the electric evoked potential detection module, obtains an acoustic-electric stimulation interference analysis result when the cochlear is electrically stimulated based on the hearing evoked potential, the electric evoked compound action potential and the cochlear inner ear electrogram, and sets an individualized optimal combined stimulation strategy according to the acoustic-electric stimulation interference analysis result;
the configuration parameters of the hearing evoked potential monitoring module comprise repeated stimulation rate, acoustic stimulation intensity, acoustic stimulation time course and acoustic stimulation frequency;
the configuration parameters of the electric evoked potential detection module comprise repeated stimulation rate, acoustic-electric interval parameters, and the intensity, pulse width and stimulation mode of electric stimulation;
the synchronous trigger circuit realizes that cochlear sound and electric stimulation are carried out in a certain time sequence and space, after the auditory evoked potential detection module releases single sound stimulation, the synchronous trigger circuit sends synchronous trigger signals to the electric evoked potential detection module at the same time, and the electric evoked potential detection module starts to release electric stimulation signals after delay according to set sound electric interval parameters so as to ensure that each sound stimulation can be coupled with one electric stimulation at a fixed interval, and can carry out repeated sampling after the sound stimulation is finished, and the sampling result is overlapped to improve the signal to noise ratio so as to obtain clear electrophysiological waveforms.
2. The cochlear acoustic electrical stimulation interferometry recording analysis device of claim 1, wherein the auditory evoked potential detection module comprises an auditory evoked potential instrument, a signal amplifier, a filter, an earpiece, and a recording electrode, the auditory evoked potential instrument being connected to the filter and the earpiece, respectively, the filter, the signal amplifier, and the recording electrode being connected in sequence.
3. The cochlear acoustic electrical stimulation interferometry recording analysis device of claim 2, wherein the recording electrode is a body surface electrode.
4. The cochlear acoustic electrical stimulation interferometry recording analysis apparatus of claim 1, wherein the electrical evoked potential monitoring module comprises:
the trigger end input interface is used for receiving the trigger signal and generating a specific electric stimulation pulse sequence according to parameter configuration of the control module;
and the electric evoked potential data analysis module is used for decoding the potential information transmitted by the implant interface and transmitting the decoded potential information to the control module.
5. The cochlear acoustic electrical stimulation interferometry recording analysis device according to claim 1, wherein the synchronous trigger circuit comprises two interfaces with electrical structures respectively adapted to the auditory evoked potential monitoring module and the electrical evoked potential monitoring module, the two interfaces being connected by a wire.
6. The cochlear acoustic electrical stimulation interferometry recording analysis device according to claim 1, wherein the implant interface comprises an adapter, a stimulator, or a radio frequency coil.
7. The cochlear acoustic electrical stimulation interferometry recording analysis apparatus of claim 1, wherein the control module comprises a first controller for connection with an auditory evoked potential monitoring module and a second controller for connection with an electrical evoked potential monitoring module.
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