CN116270955A - Preparation method of flavored wrinkled giant hyssop vital energy oral liquid - Google Patents
Preparation method of flavored wrinkled giant hyssop vital energy oral liquid Download PDFInfo
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- CN116270955A CN116270955A CN202310363385.7A CN202310363385A CN116270955A CN 116270955 A CN116270955 A CN 116270955A CN 202310363385 A CN202310363385 A CN 202310363385A CN 116270955 A CN116270955 A CN 116270955A
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- Prior art keywords
- oral liquid
- flavored
- volatile oil
- vital energy
- wrinkled giant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007788 liquid Substances 0.000 title claims abstract description 34
- 240000004510 Agastache rugosa Species 0.000 title claims abstract description 19
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000000341 volatile oil Substances 0.000 claims abstract description 42
- 238000001914 filtration Methods 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 25
- 239000000412 dendrimer Substances 0.000 claims abstract description 24
- 229920000736 dendritic polymer Polymers 0.000 claims abstract description 24
- 238000000034 method Methods 0.000 claims abstract description 24
- 238000002156 mixing Methods 0.000 claims abstract description 21
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 15
- 229920000053 polysorbate 80 Polymers 0.000 claims abstract description 15
- 239000002904 solvent Substances 0.000 claims abstract description 13
- 241001673966 Magnolia officinalis Species 0.000 claims abstract description 12
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims abstract description 12
- 229940068968 polysorbate 80 Drugs 0.000 claims abstract description 12
- 241001529821 Agastache Species 0.000 claims abstract description 11
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 10
- 238000001816 cooling Methods 0.000 claims abstract description 10
- 238000004821 distillation Methods 0.000 claims abstract description 10
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims abstract description 10
- 235000010234 sodium benzoate Nutrition 0.000 claims abstract description 10
- 239000004299 sodium benzoate Substances 0.000 claims abstract description 10
- 229920000136 polysorbate Polymers 0.000 claims abstract description 9
- 229950008882 polysorbate Drugs 0.000 claims abstract description 7
- 241001522129 Pinellia Species 0.000 claims abstract description 3
- 239000012530 fluid Substances 0.000 claims abstract 2
- BAPJBEWLBFYGME-UHFFFAOYSA-N Methyl acrylate Chemical compound COC(=O)C=C BAPJBEWLBFYGME-UHFFFAOYSA-N 0.000 claims description 34
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims description 22
- 239000012528 membrane Substances 0.000 claims description 11
- 239000000919 ceramic Substances 0.000 claims description 9
- 239000011148 porous material Substances 0.000 claims description 9
- 229920001661 Chitosan Polymers 0.000 claims description 7
- 230000002194 synthesizing effect Effects 0.000 claims description 7
- 239000000178 monomer Substances 0.000 claims description 2
- 238000001728 nano-filtration Methods 0.000 claims description 2
- 235000010686 Agastache rugosa Nutrition 0.000 claims 2
- 244000061520 Angelica archangelica Species 0.000 claims 1
- 235000001287 Guettarda speciosa Nutrition 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 3
- 238000005325 percolation Methods 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 30
- 239000000243 solution Substances 0.000 description 24
- 230000000052 comparative effect Effects 0.000 description 7
- 235000019341 magnesium sulphate Nutrition 0.000 description 5
- CSNNHWWHGAXBCP-UHFFFAOYSA-L magnesium sulphate Substances [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 5
- 239000011259 mixed solution Substances 0.000 description 5
- 239000012299 nitrogen atmosphere Substances 0.000 description 5
- 238000002390 rotary evaporation Methods 0.000 description 5
- 244000273928 Zingiber officinale Species 0.000 description 3
- 235000006886 Zingiber officinale Nutrition 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
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- 230000001105 regulatory effect Effects 0.000 description 3
- 235000004347 Perilla Nutrition 0.000 description 2
- 244000124853 Perilla frutescens Species 0.000 description 2
- 240000002505 Pogostemon cablin Species 0.000 description 2
- 235000011751 Pogostemon cablin Nutrition 0.000 description 2
- 125000003277 amino group Chemical group 0.000 description 2
- 238000005189 flocculation Methods 0.000 description 2
- 230000016615 flocculation Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 241000213006 Angelica dahurica Species 0.000 description 1
- 244000080767 Areca catechu Species 0.000 description 1
- 241000132012 Atractylodes Species 0.000 description 1
- 241000092665 Atractylodes macrocephala Species 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000009084 Cold Injury Diseases 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 239000009711 Huoxiang-zhengqi Substances 0.000 description 1
- 206010061245 Internal injury Diseases 0.000 description 1
- 244000274050 Platycodon grandiflorum Species 0.000 description 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
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- 244000126002 Ziziphus vulgaris Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
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- 230000002708 enhancing effect Effects 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
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- 208000011580 syndromic disease Diseases 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
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Abstract
The invention discloses a preparation method of flavored wrinkled giant hyssop vital energy oral liquid, which relates to the field of traditional Chinese medicine pharmacy, and comprises the steps of percolating pinellia ternate and radix angelicae by using ethanol as a solvent according to a percolation method of fluid extract, obtaining a percolate, and recovering ethanol; extracting volatile oil from herba Agastaches, atractylodis rhizoma, cortex Magnolia officinalis, pericarpium Citri Tangerinae and folium Perillae by distillation to obtain volatile oil; decocting the residue, poria, radix Platycodi, glycyrrhrizae radix, pericarpium Arecae, fructus Jujubae and rhizoma Zingiberis recens with water for at least three times, mixing decoctions, filtering, concentrating, mixing with percolate, standing, filtering, concentrating, adding sodium benzoate, and cooling to obtain concentrated solution; adding a solubilizing agent polysorbate 80 or a mixture of polysorbate and polyamide-amine dendritic polymer into the volatile oil, adding the mixture into the concentrated solution, and adding water to obtain the product. The invention ensures that the volatile oil and the concentrated solution have good compatibility, greatly improves the clarity of the oral liquid and reduces the possibility of layering.
Description
Technical Field
The invention relates to the field of traditional Chinese medicine pharmacy, in particular to a preparation method of an flavored wrinkled giant hyssop vital energy oral liquid.
Background
The Huoxiang Zhengqi prescription consists of thirteen traditional Chinese medicines of patchouli, perilla leaf, angelica dahurica, stir-fried atractylodes macrocephala, dried orange peel, ginger processed pinellia, ginger processed magnolia bark, poria cocos, platycodon grandiflorum, liquorice, areca peel, jujube and ginger, has the effects of relieving exterior syndrome and eliminating dampness, regulating qi and regulating middle warmer, is mainly used for treating wind cold and internal injury and dampness stagnation, and is a common summer heat relieving medicine in summer. The pharmacological actions of the Chinese medicinal composition mainly comprise stopping vomiting, easing pain, relieving spasm, enhancing cellular immunity and inhibiting bacteria.
However, in the preparation method of the flavored wrinkled giant hyssop vital energy oral liquid, volatile oil is distilled and extracted from patchouli, bighead atractylodes rhizome, magnolia bark, dried orange peel and perilla leaf, the obtained volatile oil is directly added during preparation, the prepared flavored wrinkled giant hyssop vital energy oral liquid can cause the phenomenon that volatile oil floats on the liquid surface and oil marks are attached to the bottle wall during pouring in the long-term storage process, and a small amount of shaking and easy-to-scatter sediment is arranged at the bottom, so that the appearance and clinical curative effect of the product are affected.
Disclosure of Invention
The invention aims to at least solve one of the technical problems in the prior art and provides a preparation method of flavored wrinkled giant hyssop vital energy oral liquid.
The technical scheme of the invention is as follows:
a method for preparing an oral liquid containing herba Agastaches for regulating vital energy comprises percolating rhizoma Pinelliae and radix Angelicae Dahuricae with ethanol as solvent to obtain percolate, and recovering ethanol; extracting volatile oil from herba Agastaches, atractylodis rhizoma, cortex Magnolia officinalis, pericarpium Citri Tangerinae and folium Perillae by distillation to obtain volatile oil; decocting the residue, poria, radix Platycodi, glycyrrhrizae radix, pericarpium Arecae, fructus Jujubae and rhizoma Zingiberis recens with water for at least three times, mixing decoctions, filtering, concentrating, mixing with percolate, standing, filtering, concentrating, adding sodium benzoate, and cooling to obtain concentrated solution;
adding a solubilizing agent polysorbate 80 or a mixture of polysorbate and polyamide-amine dendritic polymer into the volatile oil, adding the mixture into the concentrated solution, and adding water to obtain the product.
As a preferable scheme of the invention, the mass ratio of the polysorbate 80 to the volatile oil is 3-10:1.
As a preferred embodiment of the invention, the mass ratio of the polysorbate to the polyamide-amine dendrimer is 1-3:1.
As a preferred embodiment of the present invention, the preparation method of the polyamide-amine type dendritic polymer comprises the following steps: methyl acrylate and ethylenediamine are used as starting monomers, and the preparation method comprises the steps of synthesizing at least 3.5-generation polyamide-amine dendritic polymer, and then purifying.
As a preferred embodiment of the invention, the mixture comprises 1-10wt% of the volatile oil.
As a preferred embodiment of the present invention, the primary filtration is performed by using a ceramic membrane having a pore size of 30 to 60 nm.
As a preferred embodiment of the present invention, the secondary filtration uses nanofiltration membranes with a molecular weight cut-off of 100-300 daltons.
As a preferable scheme of the invention, the volume concentration of the ethanol is 70-90%.
As a preferred embodiment of the present invention, chitosan is further added to the mixture.
The beneficial effects of the invention are as follows:
(1) According to the preparation method of the flavored wrinkled giant hyssop vital energy oral liquid, the tween with a branched structure and the polymer with dendritic macromolecules are added into the volatile oil, so that the linear chain and the dendritic can form a network structure with more cavities, and the hydrophobic and hydrophilic groups are combined on the linear chain and the dendritic, so that the flavored wrinkled giant hyssop vital energy oral liquid has excellent amphipathic property, so that the volatile oil and the concentrated solution have good compatibility, the clarity of the oral liquid is greatly improved, and the layering possibility is reduced.
(2) According to the preparation method of the flavored wrinkled giant hyssop vital energy oral liquid, the chitosan is further added, amino groups on the chitosan have a complexing effect, so that the flocculation sedimentation effect is achieved, and the clarity of the oral liquid is further improved.
Detailed Description
The technical scheme of the invention is further described in the following specific examples.
Tween 80 has the structural formula:
the following examples were formulated as follows:
example 1
A method for preparing JIAWEIHUANGZHENGQI oral liquid comprises percolating rhizoma Pinelliae and radix Angelicae Dahuricae with 70% (v/v) ethanol as solvent to obtain percolate, and recovering ethanol; extracting volatile oil from herba Agastaches, atractylodis rhizoma, cortex Magnolia officinalis, pericarpium Citri Tangerinae and folium Perillae by distillation to obtain volatile oil; decocting the residue, poria, radix Platycodi, glycyrrhrizae radix, pericarpium Arecae, fructus Jujubae and rhizoma Zingiberis recens with water for three times, the first time for 2 hr, and the second and third times for 1 hr, adding 4 times of water each time, mixing decoctions, filtering, concentrating, mixing with percolate, standing, filtering, concentrating to 1000ml, adding 3g sodium benzoate, and cooling to obtain concentrated solution;
adding polysorbate 80 15g into the volatile oil, adding the mixture into the concentrated solution, and adding water to 1000 ml.
The primary filtration adopts a ceramic membrane with the pore diameter of 45 nm.
The molecular weight cut-off is 200 channels for the secondary filtration.
Example 2
A method for preparing JIAWEIHUANGZHENGQI oral liquid comprises percolating rhizoma Pinelliae and radix Angelicae Dahuricae with 70% (v/v) ethanol as solvent to obtain percolate, and recovering ethanol; extracting volatile oil from herba Agastaches, atractylodis rhizoma, cortex Magnolia officinalis, pericarpium Citri Tangerinae and folium Perillae by distillation to obtain volatile oil; decocting the residue, poria, radix Platycodi, glycyrrhrizae radix, pericarpium Arecae, fructus Jujubae and rhizoma Zingiberis recens with water for three times, the first time for 2 hr, and the second and third times for 1 hr, adding 4 times of water each time, mixing decoctions, filtering, concentrating, mixing with percolate, standing, filtering, concentrating to 1000ml, adding 3g sodium benzoate, and cooling to obtain concentrated solution;
15g of a mixture of polysorbate 80 and a polyamide-amine type dendrimer was added to the volatile oil, and the mixture was added to the concentrated solution, followed by adding water to 1000 ml.
The mass ratio of the polysorbate 80 to the polyamide-amine dendritic polymer is 1:1.
The preparation method of the polyamide-amine dendritic polymer comprises the following steps: dropwise adding Ethylenediamine (EDA) and methanol solution into Methyl Acrylate (MA) in an ice bath salt at the temperature of minus 10 ℃ under the nitrogen atmosphere, reacting for 48 hours with the molar ratio of EDA to MA of 1:5, performing rotary evaporation to obtain 0.5G dendritic molecules, continuously adding 0.5G into the mixed solution of ethylenediamine and methanol, reacting to obtain 1G dendritic molecules, and continuously synthesizing 1G and 2G according to the method until 3.5G dendritic molecules are synthesized.
The primary filtration adopts a ceramic membrane with the pore diameter of 50 nm.
The molecular weight cut-off is 200 channels for the secondary filtration.
Chitosan is also added into the mixture.
Example 3
A method for preparing JIAWEIHUANGZHENGQI oral liquid comprises percolating rhizoma Pinelliae and radix Angelicae Dahuricae with 70% (v/v) ethanol as solvent to obtain percolate, and recovering ethanol; extracting volatile oil from herba Agastaches, atractylodis rhizoma, cortex Magnolia officinalis, pericarpium Citri Tangerinae and folium Perillae by distillation to obtain volatile oil; decocting the residue, poria, radix Platycodi, glycyrrhrizae radix, pericarpium Arecae, fructus Jujubae and rhizoma Zingiberis recens with water for three times, the first time for 2 hr, and the second and third times for 1 hr, adding 4 times of water each time, mixing decoctions, filtering, concentrating, mixing with percolate, standing, filtering, concentrating to 1000ml, adding 3g sodium benzoate, and cooling to obtain concentrated solution;
adding 15g of mixture of polysorbate and polyamide-amine dendritic polymer into the volatile oil, adding the mixture into concentrated solution, and adding water to obtain the product.
The mass ratio of the polysorbate to the polyamide-amine dendritic polymer is 2:1.
The preparation method of the polyamide-amine dendritic polymer comprises the following steps: dropwise adding Ethylenediamine (EDA) and methanol solution into Methyl Acrylate (MA) in an ice bath salt at the temperature of minus 10 ℃ under the nitrogen atmosphere, reacting for 48 hours with the molar ratio of EDA to MA of 1:5, performing rotary evaporation to obtain 0.5G dendritic molecules, continuously adding 0.5G into the mixed solution of ethylenediamine and methanol, reacting to obtain 1G dendritic molecules, and continuously synthesizing 1G and 2G according to the method until 3.5G dendritic molecules are synthesized.
The primary filtration adopts a ceramic membrane with the pore diameter of 45 nm.
The molecular weight cut-off is 250 channels for the secondary filtration.
Example 4
A method for preparing JIAWEIHUANGZHENGQI oral liquid comprises percolating rhizoma Pinelliae and radix Angelicae Dahuricae with 70% (v/v) ethanol as solvent to obtain percolate, and recovering ethanol; extracting volatile oil from herba Agastaches, atractylodis rhizoma, cortex Magnolia officinalis, pericarpium Citri Tangerinae and folium Perillae by distillation to obtain volatile oil; decocting the residue, poria, radix Platycodi, glycyrrhrizae radix, pericarpium Arecae, fructus Jujubae and rhizoma Zingiberis recens with water for three times, the first time for 2 hr, and the second and third times for 1 hr, adding 4 times of water each time, mixing decoctions, filtering, concentrating, mixing with percolate, standing, filtering, concentrating to 1000ml, adding 3g sodium benzoate, and cooling to obtain concentrated solution;
15g of a mixture of polysorbate 80 and a polyamide-amine type dendrimer was added to the volatile oil, and the mixture was added to the concentrated solution, followed by adding water to 1000 ml.
The mass ratio of polysorbate 80 to polyamide-amine dendrimer is 3:1.
The preparation method of the polyamide-amine dendritic polymer comprises the following steps: dropwise adding Ethylenediamine (EDA) and methanol solution into Methyl Acrylate (MA) in an ice bath salt at the temperature of minus 10 ℃ under the nitrogen atmosphere, reacting for 48 hours with the molar ratio of EDA to MA of 1:5, performing rotary evaporation to obtain 0.5G dendritic molecules, continuously adding 0.5G into the mixed solution of ethylenediamine and methanol, reacting to obtain 1G dendritic molecules, and continuously synthesizing 1G and 2G according to the method until 4G dendritic molecules are synthesized.
The primary filtration adopts a ceramic membrane with the pore diameter of 60 nm.
The molecular weight cut-off is 180 channels.
Example 5
A method for preparing JIAWEIHUANGZHENGQI oral liquid comprises percolating rhizoma Pinelliae and radix Angelicae Dahuricae with 70% (v/v) ethanol as solvent to obtain percolate, and recovering ethanol; extracting volatile oil from herba Agastaches, atractylodis rhizoma, cortex Magnolia officinalis, pericarpium Citri Tangerinae and folium Perillae by distillation to obtain volatile oil; decocting the residue, poria, radix Platycodi, glycyrrhrizae radix, pericarpium Arecae, fructus Jujubae and rhizoma Zingiberis recens with water for three times, the first time for 2 hr, and the second and third times for 1 hr, adding 4 times of water each time, mixing decoctions, filtering, concentrating, mixing with percolate, standing, filtering, concentrating to 1000ml, adding 3g sodium benzoate, and cooling to obtain concentrated solution;
15g of a mixture of polysorbate 80 and a polyamide-amine type dendrimer was added to the volatile oil, and the mixture was added to the concentrated solution, followed by adding water to 1000 ml.
The mass ratio of polysorbate 80 to polyamide-amine dendrimer is 3:1.
The preparation method of the polyamide-amine dendritic polymer comprises the following steps: dropwise adding Ethylenediamine (EDA) and methanol solution into Methyl Acrylate (MA) in an ice bath salt at the temperature of minus 10 ℃ under the nitrogen atmosphere, reacting for 48 hours with the molar ratio of EDA to MA of 1:5, performing rotary evaporation to obtain 0.5G dendritic molecules, continuously adding 0.5G into the mixed solution of ethylenediamine and methanol, reacting to obtain 1G dendritic molecules, and continuously synthesizing 1G and 2G according to the method until 4G dendritic molecules are synthesized.
The primary filtration adopts a ceramic membrane with the pore diameter of 60 nm.
The molecular weight cut-off is 180 channels.
1wt% chitosan was also added to the mixture.
Comparative example 1 (Tween 80 free)
A method for preparing JIAWEIHUANGZHENGQI oral liquid comprises percolating rhizoma Pinelliae and radix Angelicae Dahuricae with 70% (v/v) ethanol as solvent to obtain percolate, and recovering ethanol; extracting volatile oil from herba Agastaches, atractylodis rhizoma, cortex Magnolia officinalis, pericarpium Citri Tangerinae and folium Perillae by distillation to obtain volatile oil; decocting the residue, poria, radix Platycodi, glycyrrhrizae radix, pericarpium Arecae, fructus Jujubae and rhizoma Zingiberis recens with water for three times, the first time for 2 hr, and the second and third times for 1 hr, adding 4 times of water each time, mixing decoctions, filtering, concentrating, mixing with percolate, standing, filtering, concentrating to 1000ml, adding 3g sodium benzoate, and cooling to obtain concentrated solution;
15g of a mixture of polyamide-amine type dendritic polymer was added to the volatile oil, and the mixture was added to the concentrated solution, followed by adding water to 1000 ml.
The preparation method of the polyamide-amine dendritic polymer comprises the following steps: dropwise adding Ethylenediamine (EDA) and methanol solution into Methyl Acrylate (MA) in an ice bath salt at the temperature of minus 10 ℃ under the nitrogen atmosphere, reacting for 48 hours with the molar ratio of EDA to MA of 1:5, performing rotary evaporation to obtain 0.5G dendritic molecules, continuously adding 0.5G into the mixed solution of ethylenediamine and methanol, reacting to obtain 1G dendritic molecules, and continuously synthesizing 1G and 2G according to the method until 4G dendritic molecules are synthesized.
The primary filtration adopts a ceramic membrane with the pore diameter of 60 nm.
The molecular weight cut-off is 180 channels.
Comparative example 2 (mixture without tween 80 and dendrimer)
A method for preparing JIAWEIHUANGZHENGQI oral liquid comprises percolating rhizoma Pinelliae and radix Angelicae Dahuricae with 70% (v/v) ethanol as solvent to obtain percolate, and recovering ethanol; extracting volatile oil from herba Agastaches, atractylodis rhizoma, cortex Magnolia officinalis, pericarpium Citri Tangerinae and folium Perillae by distillation to obtain volatile oil; decocting the residue, poria, radix Platycodi, glycyrrhrizae radix, pericarpium Arecae, fructus Jujubae and rhizoma Zingiberis recens with water for three times, the first time for 2 hr, and the second and third times for 1 hr, adding 4 times of water each time, mixing decoctions, filtering, concentrating, mixing with percolate, standing, filtering, concentrating to 1000ml, adding 3g sodium benzoate, and cooling to obtain concentrated solution;
mixing the volatile oil and the concentrated solution, and adding water to 1000 ml.
The primary filtration adopts a ceramic membrane with the pore diameter of 60 nm.
The molecular weight cut-off is 180 channels.
The samples prepared in the examples and comparative examples were packaged on the market, and left for 6 months at a temperature of 40.+ -. 2 ℃ and a relative humidity of 75%.+ -. 5%, and the properties and clarity were examined by sampling at the end of 0 month, 1 month, 2 months, 3 months, 6 months and 9 months, respectively, as shown in Table 1.
Table 1 example and comparative example performance results
The results show that the performance of the examples is better than the comparative examples, probably for the following reasons: analysis of comparative example 1 shows that by adding tween with branched structure and polymer with dendritic macromolecule into volatile oil, linear chain and dendritic can form network structure with more cavities, and hydrophobic and hydrophilic groups are combined on the network structure, so that the volatile oil and concentrated solution have good compatibility, clarity of oral liquid is greatly improved, and possibility of layering is reduced. Analysis of comparative example 2 shows that the amino group on the chitosan has complexation function, plays a role in flocculation sedimentation, and further improves the clarity of the oral liquid.
The above additional technical features can be freely combined and superimposed by a person skilled in the art without conflict.
The foregoing examples have shown only the preferred embodiments of the invention, which are described in more detail and are not to be construed as limiting the scope of the invention. It should be pointed out that various other corresponding changes and modifications can be made by those skilled in the art in light of the above description of the technical solution and the idea, and all such changes and modifications are intended to be within the scope of the invention as defined in the appended claims.
Claims (9)
1. A preparation method of an oral liquid containing flavored wrinkled giant hyssop and vital energy is characterized in that pinellia ternate and angelica are subjected to diacolation according to a diacolation method of a fluid extract, ethanol is used as a solvent for diacolation, so that a diacolation liquid is obtained, and the ethanol is recovered; extracting volatile oil from herba Agastaches, atractylodis rhizoma, cortex Magnolia officinalis, pericarpium Citri Tangerinae and folium Perillae by distillation to obtain volatile oil; decocting the residue, poria, radix Platycodi, glycyrrhrizae radix, pericarpium Arecae, fructus Jujubae and rhizoma Zingiberis recens with water for at least three times, mixing decoctions, filtering, concentrating, mixing with percolate, standing, filtering, concentrating, adding sodium benzoate, and cooling to obtain concentrated solution;
adding a solubilizing agent polysorbate 80 or a mixture of polysorbate and polyamide-amine dendritic polymer into the volatile oil, adding the mixture into the concentrated solution, and adding water to obtain the product.
2. The method for preparing the flavored wrinkled giant hyssop vital energy oral liquid according to claim 1, wherein the mass ratio of the polysorbate 80 to the volatile oil is 3-10:1.
3. The method for preparing the flavored wrinkled giant hyssop vital energy oral liquid according to claim 1, wherein the mass ratio of the polysorbate to the polyamide-amine dendritic polymer is 1-3:1.
4. The method for preparing the flavored wrinkled giant hyssop vital energy oral liquid according to claim 3, wherein the preparation method of the polyamide-amine dendritic polymer is as follows: methyl acrylate and ethylenediamine are used as starting monomers, and the preparation method comprises the steps of synthesizing at least 3.5-generation polyamide-amine dendritic polymer, and then purifying.
5. The method for preparing the flavored wrinkled giant hyssop vital energy oral liquid according to claim 1, wherein the mixture accounts for 1-10wt% of the volatile oil.
6. The method for preparing the flavored wrinkled giant hyssop vital energy oral liquid according to claim 1, wherein the primary filtering adopts a ceramic membrane with the pore diameter of 30-60 nm.
7. The method for preparing an oral liquid of flavored agastache rugosa as claimed in claim 1, wherein the secondary filtration adopts nanofiltration membrane with molecular weight cut-off of 100-300 daltons.
8. The method for preparing the flavored wrinkled giant hyssop vital energy oral liquid according to claim 1, wherein the volume concentration of the ethanol is 70-90%.
9. The method for preparing an oral liquid of flavored agastache rugosa as claimed in claim 1, wherein chitosan is further added into the mixture.
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