CN116270872A - Traditional Chinese medicine composition for treating chronic kidney disease - Google Patents
Traditional Chinese medicine composition for treating chronic kidney disease Download PDFInfo
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Abstract
The application relates to the field of medicines for treating chronic kidney diseases, and provides a traditional Chinese medicine composition for treating chronic kidney diseases, wherein the composition comprises the following components in percentage by weight: 16 parts of raw astragalus, 6 parts of red ginseng, 11 parts of prepared rehmannia root, 10 parts of cornus officinalis, 11 parts of Chinese yam, 5 parts of cortex moutan, 11 parts of poria cocos, 3 parts of leech, 8 parts of earthworm, 7 parts of stiff silkworm, 7 parts of cicada slough, 2 parts of raw rhubarb and 3 parts of honey-fried licorice root. Clinical researches prove that the traditional Chinese medicine composition has the effects of reducing proteinuria, protecting renal function and regulating immune function. The application of the medicine for treating the spleen and kidney deficiency of the chronic kidney disease, especially in the 1-4 stage of the chronic kidney disease, can reduce blood creatinine, urea nitrogen and uric acid, increase glomerular filtration rate (eGFR) and delay the progress of CKD.
Description
Technical Field
The application relates to the field of medicines for treating chronic kidney diseases, in particular to a traditional Chinese medicine composition for treating chronic kidney diseases.
Background
The prevalence of chronic kidney disease (Chronic Kidney Disease, CKD) increases year by year, has become a global public health problem, has the characteristics of high prevalence, low awareness, poor prognosis and high medical cost, and is a disease which is a further hazard to human health after cardiovascular and cerebrovascular diseases, diabetes and malignant tumors. In recent years, the prevalence of CKD has increased year by year, the prevalence of the general population worldwide has increased to 14.3%, CKD eventually will progress to End Stage Renal Disease (ESRD), and such patients can only receive kidney replacement therapy, and the number of people currently receiving kidney replacement therapy worldwide has exceeded 260 ten thousand, and is expected to double by 2030 to around 540 ten thousand. Once CKD has progressed to ESRD, it not only affects the quality of life of the patient, but also places a significant economic burden on the patient and society. Meanwhile, the number of deaths caused by CKD has exceeded 100 tens of thousands per year and has grown at a higher rate.
At present, the traditional Chinese medicine composition for treating the chronic kidney disease in the prior art can not meet the current requirements for treating the chronic kidney disease, and the continuous development of new traditional Chinese medicine compositions is still expected.
Disclosure of Invention
The application provides a traditional Chinese medicine composition for treating chronic kidney diseases, which can treat the chronic kidney diseases.
In a first aspect, embodiments of the present application provide a traditional Chinese medicine composition for treating chronic kidney disease, wherein the weight percentages of the composition are: 16 parts of raw astragalus, 6 parts of red ginseng, 11 parts of prepared rehmannia root, 10 parts of cornus officinalis, 11 parts of Chinese yam, 5 parts of cortex moutan, 11 parts of poria cocos, 3 parts of leech, 8 parts of earthworm, 7 parts of stiff silkworm, 7 parts of cicada slough, 2 parts of raw rhubarb and 3 parts of honey-fried licorice root.
In a second aspect, the present application provides the use of a composition for the manufacture of a medicament for the treatment of chronic kidney disease.
In a third aspect, the present application provides a traditional Chinese medicine composition for treating chronic kidney disease, which is in the form of a tablet.
In a fourth aspect, the present application provides a traditional Chinese medicine composition for treating chronic kidney disease, which is in the form of a solution.
In a fifth aspect, the present application provides a traditional Chinese medicine composition for treating chronic kidney disease, wherein the traditional Chinese medicine composition for treating chronic kidney disease is in the form of granules.
The clinical research of the traditional Chinese medicine composition for treating chronic kidney diseases proves that the traditional Chinese medicine composition has the effects of reducing proteinuria, protecting kidney functions and regulating immunity. The application of the medicine for treating the spleen and kidney deficiency of the chronic kidney disease, especially in the 1-4 stage of the chronic kidney disease, can reduce blood creatinine, urea nitrogen and uric acid, increase glomerular filtration rate (eGFR) and delay the progress of CKD.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.
Detailed Description
All other embodiments, which can be made by one of ordinary skill in the art without undue burden from the present disclosure, are within the scope of the present disclosure.
It should be further understood that the term "and/or" as used in this specification and the appended claims refers to any and all possible combinations of one or more of the associated listed items, and includes such combinations.
The invention aims at providing a traditional Chinese medicine composition for treating renal failure aiming at the problems. Reducing proteinuria, protecting renal function, regulating immunity, and delaying chronic renal failure.
In order to solve the technical problems, the invention provides a traditional Chinese medicine composition for treating chronic renal failure, which can effectively reduce blood creatinine, urea nitrogen, uric acid and urine protein, raise glomerular filtration rate (eGFR) and delay the progress of CKD.
The application provides a traditional Chinese medicine composition for treating chronic kidney diseases, which comprises the following components in percentage by weight: 16 parts of raw astragalus, 6 parts of red ginseng, 11 parts of prepared rehmannia root, 10 parts of cornus officinalis, 11 parts of Chinese yam, 5 parts of cortex moutan, 11 parts of poria cocos, 3 parts of leech, 8 parts of earthworm, 7 parts of stiff silkworm, 7 parts of cicada slough, 2 parts of raw rhubarb and 3 parts of honey-fried licorice root.
The traditional Chinese medicine composition is prepared from pure traditional Chinese medicines, and based on the treatment principle of treating both principal and secondary aspects of CKD by the traditional Chinese medicines, the early clinical research results of the traditional Chinese medicine composition show that raw astragalus and red ginseng are reused as monarch medicines, and both the astragalus and the red ginseng enter spleen channels and lung channels, and have the effects of tonifying qi, promoting the production of body fluid and promoting the production of blood. Radix astragali is sweet and slightly warm, has the effect of promoting the subsidence of edema, and red ginseng has sweet and flat nature, can greatly tonify primordial qi, invigorate spleen and benefit lung, and is often combined with other herbs to enhance curative effect, and the principle of the recipe is that the recipe is used for the principal. Radix rehmanniae Preparata, fructus Corni, rhizoma Dioscoreae, cortex moutan, poria, hirudo, lumbricus, bombyx Batryticatus, and periostracum Cicadae can be used as ministerial drugs. The prepared rehmannia root, the wine cornus, the Chinese yam, the cortex moutan and the poria cocos take the effects of nourishing yin, tonifying kidney, clearing heat and purging fire, wherein the prepared rehmannia root, the wine cornus, the Chinese yam, the liver, the spleen and the kidney are both supplemented, the yin of the prepared rehmannia root is supplemented, the marrow of the prepared rehmannia root is filled, the cortex moutan and the poria cocos can clear heat and purge fire, invigorate the spleen and excrete dampness, and the prepared rehmannia root, the wine cornus, the Chinese yam, the liver, the spleen and the kidney have the effects of clearing heat and benefiting while purging kidney turbidity, so that the whole recipe is supplemented without stagnation. Leech and earthworm are combined in the prescription, and the effects of promoting blood circulation by removing blood stasis, clearing and activating the channels and collaterals, clearing heat and promoting urination are taken together with poria cocos, so that the traditional Chinese medicine is combined with poria cocos to promote diuresis, remove turbid urine and promote turbid toxin. The stiff silkworm, the cicada slough and the rhubarb are meant to eliminate pathogenic factors, detoxify, raise clear and lower turbid. Wherein, the stiff silkworm is pungent and salty, has the effects of clearing away heat and toxic materials, dispersing depression and dehumidification, and resolving phlegm and resolving masses; cicada slough Xin Xianliang ventilates the lung and opens orifices to clear away heat. The raw rhubarb is used as adjuvant, large Huang Guhan, has the effects of removing obstruction in the abdomen and expelling turbidity, removing stasis and resolving stagnation, promoting blood circulation and dredging channels, removing stasis and resolving hard mass, promoting aging to bring new, and regulating the five viscera, wherein the first part of the raw rhubarb can induce toxin to relieve from the stool, the second part of the raw rhubarb can ascend and descend turbidity, and the raw rhubarb can be used together with stiff silkworm and cicada slough to disperse the clear yang in the yang, descend turbid yin in the yin, remove diarrhea and eliminate pathogenic factors and treat the symptoms, and the third part of the raw rhubarb is light in dosage and eliminates pathogenic factors and does not damage the body resistance. Radix Glycyrrhizae Preparata is used for regulating the functions of the other drugs. The recipe has the effects of tonifying kidney, strengthening spleen, removing blood stasis, promoting diuresis, ascending the clear and descending the turbid, and strengthening body resistance to eliminate pathogenic factors.
The invention can continuously take antihypertensive drugs and hypoglycemic drugs for controlling basic diseases and keep the pre-index of taking the traditional Chinese medicine composition for 30 clinical patients in clinical patients of nephrology department of the traditional Chinese medicine in the period of 1-4: urea Nitrogen (BUN), serum creatinine (Scr) levels, 24 hour urine protein quantification, uric acid, hemoglobin and glomerular filtration rate calculated from serum creatinine levels, gender, age, and the index was reviewed at regular intervals for 2-4 weeks and followed by clinic.
1. Clinical data
30 cases of oral traditional Chinese medicine composition Xinjiang autonomous region traditional Chinese medicine clinical general data of nephrology department outpatient department patients in hospital
Description: (1) diagnostic criteria for Western CKD.
Note that: meets any index of the above kidney injury marks and/or eGFR is less than or equal to 60mL (min-1.73 square meter) for more than 3 months.
(2) Diagnostic criteria for traditional Chinese medicine:
the breaking standard of spleen and kidney deficiency syndrome and the quantification standard of Chinese medicine symptoms are referred to the diagnosis standard in the "clinical guidelines for new Chinese medicine" published in 4 th year 2002, and the following table is specific.
Diagnosis standard for spleen-kidney deficiency syndrome
Note that: has 2 main symptoms, 1 secondary symptoms and can be diagnosed as deficiency of both the kidney and the kidney by combining tongue-made swimming images. The doctors of the assistant and the assistant doctors and the assistant and assistant doctors are responsible for guiding the Chinese medicine syndrome score. Quantification of traditional Chinese medicine syndrome: the scores were divided into 4 grades, no, light, medium and heavy: 0. 2, 4 and 6 minutes.
(3) Inclusion criteria:
(1) meets the Western diagnosis standard of CKD1-4 stage. (2) Meets the differentiation standard of spleen and kidney deficiency syndrome of traditional Chinese medicine in CKD1-4 stage: the main symptoms are lassitude, soreness of waist and knees, dry mouth and tongue, dysphoria with feverish sensation in the chest, abdomen, nocturia, irregular stool, sticky and greasy mouth, thick and greasy tongue coating, pale tongue with teeth marks and deep and thin pulse. (3) The age is within 18-80 years. And the sex is unlimited.
(4) Exclusion criteria:
(1) acute kidney disease; (2) immunosuppressants were used for nearly 6 months; (3) intolerance to the study drug;
(4) infectious diseases; (5) severe heart, liver and lung dysfunction; (6) mental disorders; (7) incomplete clinical data;
3. glomerular filtration rate effr formula: creatinine normal value and unit 58-110umol/L; glomerular filtration rate unit ml/min.1.73m 2
Glomerular filtration rate = 141 x math.min (serum creatinine/kappa 1), alpha x math.max (serum creatinine/kappa 1), -1.209 x 0.993 years.
The CKD stage shown in this table is a Chronic Kidney Disease (CKD) stage for estimating glomerular filtration rate (evfr)
2. Evaluation of efficacy
Evaluation of patient curative effect after treatment of the traditional Chinese medicine composition:
(1) Kidney loss index change after treatment of 30 cases of kidney disease department outpatients in traditional Chinese medical hospitals in Xinjiang Uygur autonomous region
The syndrome of the traditional Chinese medicine is integrated before taking the traditional Chinese medicine composition
The syndrome of the traditional Chinese medicine after taking the traditional Chinese medicine composition is marked by the integral exterior
(2) Curative effect judgment criteria:
evaluation of therapeutic Effect of Chinese medicinal composition after treatment
The effect is shown: the clinical symptoms and signs are basically disappeared, the kidney function is obviously improved, and the serum creatinine is reduced by more than or equal to 30 percent;
the method is effective: the clinical symptoms and physical signs are improved, the renal function is improved, and the serum creatinine is reduced by more than or equal to 10 percent by 30 percent;
invalidation: the clinical symptoms are not changed or aggravated, the renal function is not obviously improved or worsened, and the serum creatinine is reduced by less than 10 percent or increased.
Description: the clinical symptoms of 9 outpatients after treatment improved, with a decrease in creatinine value of < 10%, still assigned to the active group.
In summary, the present application provides a traditional Chinese medicine composition for treating chronic kidney disease, wherein the weight percentages of the composition are as follows: 16 parts of raw astragalus, 6 parts of red ginseng, 11 parts of prepared rehmannia root, 10 parts of cornus officinalis, 11 parts of Chinese yam, 5 parts of cortex moutan, 11 parts of poria cocos, 3 parts of leech, 8 parts of earthworm, 7 parts of stiff silkworm, 7 parts of cicada slough, 2 parts of raw rhubarb and 3 parts of honey-fried licorice root.
Can effectively reduce blood creatinine, urea nitrogen, uric acid and urine protein, raise glomerular filtration rate (eGFR), delay the progress of CKD, and based on the treatment principle of the traditional Chinese medicine for treating both principal and secondary aspect of CKD, the clinical research result in the early stage of the traditional Chinese medicine composition shows that the traditional Chinese medicine composition has the effects of replenishing qi and promoting the production of body fluid and producing blood by using radix astragali and red ginseng as monarch drugs. Radix astragali is sweet and slightly warm, has the effect of promoting the subsidence of edema, and red ginseng has sweet and flat nature, can greatly tonify primordial qi, invigorate spleen and benefit lung, and is often combined with other herbs to enhance curative effect, and the principle of the recipe is that the recipe is used for the principal. Radix rehmanniae Preparata, fructus Corni, rhizoma Dioscoreae, cortex moutan, poria, hirudo, lumbricus, bombyx Batryticatus, and periostracum Cicadae can be used as ministerial drugs. The prepared rehmannia root, the wine cornus, the Chinese yam, the cortex moutan and the poria cocos take the effects of nourishing yin, tonifying kidney, clearing heat and purging fire, wherein the prepared rehmannia root, the wine cornus, the Chinese yam, the liver, the spleen and the kidney are both supplemented, the yin of the prepared rehmannia root is supplemented, the marrow of the prepared rehmannia root is filled, the cortex moutan and the poria cocos can clear heat and purge fire, invigorate the spleen and excrete dampness, and the prepared rehmannia root, the wine cornus, the Chinese yam, the liver, the spleen and the kidney have the effects of clearing heat and benefiting while purging kidney turbidity, so that the whole recipe is supplemented without stagnation. Leech and earthworm are combined in the prescription, and the effects of promoting blood circulation by removing blood stasis, clearing and activating the channels and collaterals, clearing heat and promoting urination are taken together with poria cocos, so that the traditional Chinese medicine is combined with poria cocos to promote diuresis, remove turbid urine and promote turbid toxin. The stiff silkworm, the cicada slough and the rhubarb are meant to eliminate pathogenic factors, detoxify, raise clear and lower turbid. Wherein, the stiff silkworm is pungent and salty, has the effects of clearing away heat and toxic materials, dispersing depression and dehumidification, and resolving phlegm and resolving masses; cicada slough Xin Xianliang ventilates the lung and opens orifices to clear away heat. The raw rhubarb is used as adjuvant, large Huang Guhan, has the effects of removing obstruction in the abdomen and expelling turbidity, removing stasis and resolving stagnation, promoting blood circulation and dredging channels, removing stasis and resolving hard mass, promoting aging to bring new, and regulating the five viscera, wherein the first part of the raw rhubarb can induce toxin to relieve from the stool, the second part of the raw rhubarb can ascend and descend turbidity, and the raw rhubarb can be used together with stiff silkworm and cicada slough to disperse the clear yang in the yang, descend turbid yin in the yin, remove diarrhea and eliminate pathogenic factors and treat the symptoms, and the third part of the raw rhubarb is light in dosage and eliminates pathogenic factors and does not damage the body resistance. Radix Glycyrrhizae Preparata is used for regulating the functions of the other drugs. The recipe has the effects of tonifying kidney, strengthening spleen, removing blood stasis, promoting diuresis, ascending the clear and descending the turbid, and strengthening body resistance to eliminate pathogenic factors.
The invention can continuously take antihypertensive drugs and hypoglycemic drugs for controlling basic diseases and keep the pre-index of taking the traditional Chinese medicine composition for 30 clinical patients in clinical patients of nephrology department of the traditional Chinese medicine in the period of 1-4: urea Nitrogen (BUN), serum creatinine (Scr) levels, 24 hour urine protein quantification, uric acid, hemoglobin and glomerular filtration rate calculated from serum creatinine levels, gender, age, and the index was reviewed periodically for 2-4 weeks and followed by clinic.
In a second aspect, the present application provides the use of a composition for the manufacture of a medicament for the treatment of chronic kidney disease.
In a third aspect, the present application provides a traditional Chinese medicine composition for treating chronic kidney disease, which is in the form of a tablet.
In a fourth aspect, the present application provides a traditional Chinese medicine composition for treating chronic kidney disease, which is in the form of a solution.
In a fifth aspect, the present application provides a traditional Chinese medicine composition for treating chronic kidney disease, wherein the traditional Chinese medicine composition for treating chronic kidney disease is in the form of granules.
While the invention has been described with reference to certain preferred embodiments, it will be understood by those skilled in the art that various changes and substitutions of equivalents may be made and equivalents will be apparent to those skilled in the art without departing from the scope of the invention. Therefore, the protection scope of the present application should be as defined in the claims.
Claims (5)
1. A traditional Chinese medicine composition for treating chronic kidney disease is characterized by comprising the following components in percentage by weight: 16 parts of raw astragalus, 6 parts of red ginseng, 11 parts of prepared rehmannia root, 10 parts of cornus officinalis, 11 parts of Chinese yam, 5 parts of cortex moutan, 11 parts of poria cocos, 3 parts of leech, 8 parts of earthworm, 7 parts of stiff silkworm, 7 parts of cicada slough, 2 parts of raw rhubarb and 3 parts of honey-fried licorice root.
2. Use of a composition according to claim 1 in the manufacture of a medicament for the treatment of chronic kidney disease.
3. The traditional Chinese medicine composition for treating chronic kidney disease according to claim 1, wherein the traditional Chinese medicine composition for treating chronic kidney disease is in the form of a tablet.
4. The traditional Chinese medicine composition for treating chronic kidney disease according to claim 1, wherein the traditional Chinese medicine composition for treating chronic kidney disease is in the form of a solution.
5. The traditional Chinese medicine composition for treating chronic kidney disease according to claim 1, wherein the traditional Chinese medicine composition for treating chronic kidney disease is in the form of granules.
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Non-Patent Citations (3)
| Title |
|---|
| 于俊生等: "蝉蜕、僵蚕对系膜增生性肾小球肾炎模型大鼠肾组织Toll样受体4表达的影响", 《中华中医药学刊》, vol. 33, no. 1, pages 333 - 334 * |
| 张浩文等: "复肾汤对糖尿病肾病大鼠足细胞Nephrin 和Podocin 的影响", 《药物评价研究》, vol. 42, no. 12, pages 2354 - 2359 * |
| 韩晓玲: "中西医结合治疗老年性肾病的疗效观察", 《河北北方学院学报（医学版）》, vol. 22, no. 4, pages 45 - 46 * |
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