CN116270266A - Use of zinc compounds in combination with hydrogen peroxide in oral malodour reduction products - Google Patents
Use of zinc compounds in combination with hydrogen peroxide in oral malodour reduction products Download PDFInfo
- Publication number
- CN116270266A CN116270266A CN202310186041.3A CN202310186041A CN116270266A CN 116270266 A CN116270266 A CN 116270266A CN 202310186041 A CN202310186041 A CN 202310186041A CN 116270266 A CN116270266 A CN 116270266A
- Authority
- CN
- China
- Prior art keywords
- parts
- toothpaste
- hydrogen peroxide
- zinc
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 title claims abstract description 180
- 150000003752 zinc compounds Chemical class 0.000 title claims description 28
- 230000009467 reduction Effects 0.000 title description 2
- 239000000606 toothpaste Substances 0.000 claims abstract description 138
- 229940034610 toothpaste Drugs 0.000 claims abstract description 132
- 150000001875 compounds Chemical class 0.000 claims abstract description 37
- 239000011701 zinc Substances 0.000 claims abstract description 33
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229910052725 zinc Inorganic materials 0.000 claims abstract description 32
- 206010006326 Breath odour Diseases 0.000 claims abstract description 30
- 239000002324 mouth wash Substances 0.000 claims abstract description 7
- 235000015218 chewing gum Nutrition 0.000 claims abstract description 4
- 239000007921 spray Substances 0.000 claims abstract description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 29
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 18
- 239000008367 deionised water Substances 0.000 claims description 13
- 229910021641 deionized water Inorganic materials 0.000 claims description 13
- 239000002562 thickening agent Substances 0.000 claims description 13
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 12
- 239000000377 silicon dioxide Substances 0.000 claims description 11
- 239000011787 zinc oxide Substances 0.000 claims description 11
- 235000014692 zinc oxide Nutrition 0.000 claims description 11
- 239000003906 humectant Substances 0.000 claims description 9
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 9
- 230000002087 whitening effect Effects 0.000 claims description 9
- 239000011746 zinc citrate Substances 0.000 claims description 9
- 235000006076 zinc citrate Nutrition 0.000 claims description 9
- 229940068475 zinc citrate Drugs 0.000 claims description 9
- 229920002125 Sokalan® Polymers 0.000 claims description 8
- 239000004088 foaming agent Substances 0.000 claims description 8
- 239000003381 stabilizer Substances 0.000 claims description 8
- 239000004376 Sucralose Substances 0.000 claims description 7
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 7
- 235000019408 sucralose Nutrition 0.000 claims description 7
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 6
- 239000004075 cariostatic agent Substances 0.000 claims description 6
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 6
- 239000000796 flavoring agent Substances 0.000 claims description 6
- 235000003599 food sweetener Nutrition 0.000 claims description 6
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 6
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 6
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 6
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims description 6
- 239000003765 sweetening agent Substances 0.000 claims description 6
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 6
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 5
- 230000000170 anti-cariogenic effect Effects 0.000 claims description 5
- 239000000872 buffer Substances 0.000 claims description 5
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 5
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 5
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 claims description 5
- 229940073507 cocamidopropyl betaine Drugs 0.000 claims description 5
- 239000000600 sorbitol Substances 0.000 claims description 5
- 230000008719 thickening Effects 0.000 claims description 5
- 239000000080 wetting agent Substances 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 4
- JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 claims description 4
- 229940043256 calcium pyrophosphate Drugs 0.000 claims description 4
- 235000019821 dicalcium diphosphate Nutrition 0.000 claims description 4
- 229910021485 fumed silica Inorganic materials 0.000 claims description 4
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 4
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims description 4
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims description 4
- 239000011670 zinc gluconate Substances 0.000 claims description 4
- 235000011478 zinc gluconate Nutrition 0.000 claims description 4
- 229960000306 zinc gluconate Drugs 0.000 claims description 4
- 239000006172 buffering agent Substances 0.000 claims description 3
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 235000010216 calcium carbonate Nutrition 0.000 claims description 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 3
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims description 3
- 229920001577 copolymer Polymers 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000004584 polyacrylic acid Substances 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 108700004121 sarkosyl Proteins 0.000 claims description 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 3
- 239000011775 sodium fluoride Substances 0.000 claims description 3
- 235000013024 sodium fluoride Nutrition 0.000 claims description 3
- 229960000414 sodium fluoride Drugs 0.000 claims description 3
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 claims description 3
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 claims description 3
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 claims description 3
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 claims description 3
- 229960002799 stannous fluoride Drugs 0.000 claims description 3
- 239000011592 zinc chloride Substances 0.000 claims description 3
- 235000005074 zinc chloride Nutrition 0.000 claims description 3
- 229960001939 zinc chloride Drugs 0.000 claims description 3
- 229960001296 zinc oxide Drugs 0.000 claims description 3
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 claims description 2
- 229940083982 sodium phytate Drugs 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 240000002234 Allium sativum Species 0.000 abstract description 27
- 235000004611 garlic Nutrition 0.000 abstract description 27
- 230000000694 effects Effects 0.000 abstract description 25
- 210000000214 mouth Anatomy 0.000 abstract description 25
- 150000003568 thioethers Chemical class 0.000 abstract description 20
- UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 abstract description 17
- 239000000126 substance Substances 0.000 abstract description 16
- 238000006243 chemical reaction Methods 0.000 abstract description 14
- 229910052945 inorganic sulfide Inorganic materials 0.000 abstract description 9
- 230000001877 deodorizing effect Effects 0.000 abstract description 4
- 235000002732 Allium cepa var. cepa Nutrition 0.000 abstract description 3
- 244000273928 Zingiber officinale Species 0.000 abstract description 3
- 235000006886 Zingiber officinale Nutrition 0.000 abstract description 3
- 235000008397 ginger Nutrition 0.000 abstract description 3
- 241000234282 Allium Species 0.000 abstract 1
- 229940112822 chewing gum Drugs 0.000 abstract 1
- 229940051866 mouthwash Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 description 26
- 238000009472 formulation Methods 0.000 description 22
- 230000000052 comparative effect Effects 0.000 description 21
- 230000014759 maintenance of location Effects 0.000 description 15
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 12
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 11
- 238000002791 soaking Methods 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- QMMFVYPAHWMCMS-UHFFFAOYSA-N Dimethyl sulfide Chemical compound CSC QMMFVYPAHWMCMS-UHFFFAOYSA-N 0.000 description 9
- 208000033962 Fontaine progeroid syndrome Diseases 0.000 description 8
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 8
- PFRGXCVKLLPLIP-UHFFFAOYSA-N diallyl disulfide Chemical compound C=CCSSCC=C PFRGXCVKLLPLIP-UHFFFAOYSA-N 0.000 description 8
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- XNZOTQPMYMCTBZ-UHFFFAOYSA-N allyl methyl disulfide Chemical compound CSSCC=C XNZOTQPMYMCTBZ-UHFFFAOYSA-N 0.000 description 6
- WQOXQRCZOLPYPM-UHFFFAOYSA-N dimethyl disulfide Chemical compound CSSC WQOXQRCZOLPYPM-UHFFFAOYSA-N 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 239000002994 raw material Substances 0.000 description 6
- 229920006395 saturated elastomer Polymers 0.000 description 6
- 239000002002 slurry Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 208000032139 Halitosis Diseases 0.000 description 5
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 230000003647 oxidation Effects 0.000 description 5
- 238000007254 oxidation reaction Methods 0.000 description 5
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 4
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 239000011593 sulfur Substances 0.000 description 4
- 150000003464 sulfur compounds Chemical class 0.000 description 4
- YYNJYMYRHBOARL-UHFFFAOYSA-N 7-methoxyquinoxalin-5-amine Chemical compound N1=CC=NC2=CC(OC)=CC(N)=C21 YYNJYMYRHBOARL-UHFFFAOYSA-N 0.000 description 3
- JDLKFOPOAOFWQN-VIFPVBQESA-N Allicin Natural products C=CCS[S@](=O)CC=C JDLKFOPOAOFWQN-VIFPVBQESA-N 0.000 description 3
- 244000291564 Allium cepa Species 0.000 description 3
- JDLKFOPOAOFWQN-UHFFFAOYSA-N allicin Chemical compound C=CCSS(=O)CC=C JDLKFOPOAOFWQN-UHFFFAOYSA-N 0.000 description 3
- 235000010081 allicin Nutrition 0.000 description 3
- NVLPQIPTCCLBEU-UHFFFAOYSA-N allyl methyl sulphide Natural products CSCC=C NVLPQIPTCCLBEU-UHFFFAOYSA-N 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- 230000009977 dual effect Effects 0.000 description 3
- 229920001971 elastomer Polymers 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 239000011259 mixed solution Substances 0.000 description 3
- -1 trans-propenyl-isopropenyl disulfide Chemical compound 0.000 description 3
- FUDUFCLRGSEHAJ-ARJAWSKDSA-N (e)-methyl 1-propenyl disulfide Chemical compound CSS\C=C/C FUDUFCLRGSEHAJ-ARJAWSKDSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- XUHLIQGRKRUKPH-GCXOYZPQSA-N Alliin Natural products N[C@H](C[S@@](=O)CC=C)C(O)=O XUHLIQGRKRUKPH-GCXOYZPQSA-N 0.000 description 2
- 239000004604 Blowing Agent Substances 0.000 description 2
- UBJVUCKUDDKUJF-UHFFFAOYSA-N Diallyl sulfide Chemical compound C=CCSCC=C UBJVUCKUDDKUJF-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
- XUHLIQGRKRUKPH-UHFFFAOYSA-N S-allyl-L-cysteine sulfoxide Natural products OC(=O)C(N)CS(=O)CC=C XUHLIQGRKRUKPH-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- XUHLIQGRKRUKPH-DYEAUMGKSA-N alliin Chemical compound OC(=O)[C@@H](N)C[S@@](=O)CC=C XUHLIQGRKRUKPH-DYEAUMGKSA-N 0.000 description 2
- 235000015295 alliin Nutrition 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000000903 blocking effect Effects 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 230000009965 odorless effect Effects 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
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- 239000013558 reference substance Substances 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 239000004408 titanium dioxide Substances 0.000 description 2
- 229910052984 zinc sulfide Inorganic materials 0.000 description 2
- FUDUFCLRGSEHAJ-ONEGZZNKSA-N (e)-1-methyldisulfanylprop-1-ene Chemical compound CSS\C=C\C FUDUFCLRGSEHAJ-ONEGZZNKSA-N 0.000 description 1
- MBNVSWHUJDDZRH-UHFFFAOYSA-N 2-methylthiirane Chemical compound CC1CS1 MBNVSWHUJDDZRH-UHFFFAOYSA-N 0.000 description 1
- 240000006108 Allium ampeloprasum Species 0.000 description 1
- 235000005254 Allium ampeloprasum Nutrition 0.000 description 1
- 235000010167 Allium cepa var aggregatum Nutrition 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 102000001848 Salivary Proteins and Peptides Human genes 0.000 description 1
- 108010029987 Salivary Proteins and Peptides Proteins 0.000 description 1
- 239000005083 Zinc sulfide Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000019820 disodium diphosphate Nutrition 0.000 description 1
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
- VTIIJXUACCWYHX-UHFFFAOYSA-L disodium;carboxylatooxy carbonate Chemical compound [Na+].[Na+].[O-]C(=O)OOC([O-])=O VTIIJXUACCWYHX-UHFFFAOYSA-L 0.000 description 1
- 150000002019 disulfides Chemical class 0.000 description 1
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- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
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- 235000015243 ice cream Nutrition 0.000 description 1
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- 230000002401 inhibitory effect Effects 0.000 description 1
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- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 1
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- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
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- DRDVZXDWVBGGMH-UHFFFAOYSA-N zinc;sulfide Chemical compound [S-2].[Zn+2] DRDVZXDWVBGGMH-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
- A61K2800/882—Mixing prior to application
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention provides application of a zinc-containing compound and hydrogen peroxide in a product for removing bad breath, and particularly relates to the technical field of daily chemicals. The oral malodor-removing product comprises toothpaste, mouthwash, mouth spray, chewing gum, and mouthrinse. The zinc-containing compound and hydrogen peroxide provided by the invention are combined in the product for removing the oral cavity odor, so that better collocation is provided for removing the oral cavity odor: the hydrogen peroxide converts organic sulfides in the VSCs into inorganic sulfides with peculiar smell and organic sulfides without peculiar smell, and the inorganic sulfides are removed through reaction, so that the VSCs have remarkable peculiar smell removing effect; the zinc-containing compound can remove inorganic sulfide in the oral cavity, further remove bad breath, and has remarkable deodorizing effect on the bad breath and the organic sulfide remained after eating the onion, ginger and garlic.
Description
Technical Field
The invention relates to the technical field of daily chemical products, in particular to application of a zinc-containing compound and hydrogen peroxide in a product for removing bad breath.
Background
Oral malodour or "bad breath" is a term used to describe unpleasant odours in exhaled breath. It is mainly derived from the production of Volatile Sulfur Compounds (VSCs) in the oral cavity. The compound is produced by microbial degradation of amino acids in food residues, shed oral epithelial cells and salivary proteins. Oral cavity generated VSCs consist mainly of hydrogen sulfide, methyl mercaptan, dimethyl sulfide, dimethyl disulfide, allyl methyl sulfide, and even very low concentrations of hydrogen sulfide produce a significant unpleasant odor. Oral malodour is a common oral problem in the general population, which can lead to personal discomfort and social embarrassment. At the same time, volatile sulfides can also cause gingivitis and periodontitis related diseases, and periodontal disease patients often experience halitosis.
The main principle of the inorganic hydrogen sulfide used in the toothpaste for removing the bad breath is that alkaline substances in the toothpaste convert acid gas hydrogen sulfide into sulfide salt, then the sulfide salt interacts with zinc ions to produce zinc sulfide solid which is indissolvable in water, and finally the oral cavity is rinsed along with the subsequent tooth brushing and rinsing actions of consumers, thereby playing the role of relieving the bad breath. The odor removing principle of zinc ions has limitation, mainly aims at inorganic hydrogen sulfide in the oral cavity, and has almost no effect on organic sulfide methyl mercaptan, dimethyl sulfide, dimethyl disulfide, allyl methyl sulfide and the like.
In view of this, the present invention has been made.
Disclosure of Invention
One of the purposes of the present invention is to provide an application of zinc-containing compound and hydrogen peroxide in oral malodor removing products, so as to alleviate the technical problem that zinc ions cannot remove all volatile sulfur-containing compounds in the prior art.
The second object of the invention is to provide a toothpaste for removing bad breath.
In order to solve the technical problems, the invention adopts the following technical scheme:
in a first aspect the present invention provides the use of a zinc compound in combination with hydrogen peroxide in a product for the removal of malodour.
Further, the oral malodour-removing products include toothpastes, mouthwashes, mouth sprays, tooth cleaners, chewing gums and mouth rinses.
In a second aspect the present invention provides a toothpaste for removing malodour in the mouth, the toothpaste being a dual tube toothpaste comprising a zinc compound containing toothpaste and a hydrogen peroxide containing toothpaste;
the zinc-containing compound toothpaste comprises, by weight, 10-16 parts of an abrasive, 2.2-7.8 parts of a thickener, 0.38-1.14 parts of an anticariogenic agent, 1.1-3.3 parts of a foaming agent, 25-60 parts of a humectant, 0.4-8.5 parts of a whitening agent, 0.18-3.8 parts of a zinc-containing compound and 12-25 parts of deionized water.
Further, the hydrogen peroxide-containing toothpaste is a hydrogen peroxide-containing anhydrous toothpaste or a hydrogen peroxide-containing hydrous toothpaste.
Further, the anhydrous hydrogen peroxide-containing toothpaste comprises 30.1-44 parts of abrasive, 0.38-1.14 parts of anticariogenic agent, 1.4-2.8 parts of foaming agent, 3-10 parts of stabilizer, 5-20 parts of PEG-8, 10-20 parts of glycerin and 2-18 parts of PVP-hydrogen peroxide. Further, the aqueous hydrogen peroxide-containing toothpaste comprises 5-15 parts of wetting agent, 0.2-1.2 parts of thickener, 0.2-0.8 parts of buffer, 5-15 parts of PEG-8, 40-75 parts of deionized water and 2-18 parts of PVP-hydrogen peroxide.
Further, the zinc-containing compound includes at least one of zinc citrate, zinc oxide, zinc chloride, and zinc gluconate.
Further, the abrasive comprises at least one of calcium pyrophosphate, calcium hydrogen phosphate, calcium carbonate, calcium hydrogen phosphate dihydrate, and abrasive silica.
Preferably, the anticaries agent includes at least one of sodium monofluorophosphate, sodium fluoride, and stannous fluoride.
Preferably, the foaming agent comprises at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate and cocamidopropyl betaine.
Preferably, the thickener comprises at least one of carbomers, thickening silica, cellulose gum and xanthan gum.
Further, the stabilizer comprises at least one of fumed silica, polyacrylic acid, polyvinylpyrrolidone, and PEG/PPG-116/66 copolymer.
Preferably, the wetting agent comprises glycerol and/or propylene glycol.
Preferably, the buffering agent comprises sodium hydroxide, sodium bicarbonate.
Preferably, the humectant comprises sorbitol, PEG-8, glycerin and propylene glycol.
Preferably, the whitening agent comprises tetrasodium pyrophosphate and/or sodium phytate.
Further, the zinc compound-containing toothpaste, the hydrogen peroxide-containing anhydrous toothpaste or the hydrogen peroxide-containing hydrated toothpaste further comprises a flavor or sweetener.
Preferably, the sweetener comprises sucralose.
Compared with the prior art, the invention has at least the following beneficial effects:
the zinc-containing compound and hydrogen peroxide provided by the invention are combined in the product for removing the oral cavity odor, so that better collocation is provided for removing the oral cavity odor: the hydrogen peroxide converts organic sulfide in the VSC into inorganic sulfide with peculiar smell and organic sulfide without peculiar smell, and the inorganic sulfide is removed by reaction, so that the VSC has remarkable peculiar smell removing effect; the zinc-containing compound can remove inorganic sulfide in the oral cavity, further remove bad breath, and has remarkable deodorizing effect on the bad breath and the organic sulfide remained after eating the onion, ginger and garlic.
The toothpaste for removing the oral cavity odor provided by the invention adopts the form of double-tube toothpaste, and the toothpaste containing hydrogen peroxide and zinc compounds is placed in two different tube cavities in a double-tube physical blocking manner, so that the stability of the hydrogen peroxide is prevented from being damaged by the zinc compounds or other chemical components in the common toothpaste, and the use effect and the shelf life of the toothpaste are ensured.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions in the embodiments of the present invention will be clearly and completely described in the following in conjunction with the embodiments of the present invention, and it is apparent that the described embodiments are some embodiments of the present invention, but not all embodiments. The components of embodiments of the present invention may be arranged and designed in a wide variety of different configurations.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
In particular, in northern China, people like to eat garlic, and the whole garlic has no obvious smell, and the garlic contains a chemical substance of alliin, so that the substance has no pungent smell. However, when garlic is cut or crushed, the tissue of the garlic is broken, and alliin contained in the cells is converted into allicin which is a volatile substance having strong pungent taste under the action of allinase and other coenzymes, and the allicin is spicy, irritative and appetizing, which is a main source of garlic taste and is a cause of the garlic favor of many people. Allicin is unstable and breaks down into various organic sulfides. VSCs responsible for bad breath are mainly hydrogen sulfide, methyl mercaptan, dimethyl sulfide, dimethyl disulfide, allyl methyl sulfide, etc.
In a first aspect the present invention provides the use of a zinc compound in combination with hydrogen peroxide in a product for the removal of malodour.
The zinc-containing compound and hydrogen peroxide provided by the invention are combined in the product for removing the oral cavity odor, so that better collocation is provided for removing the oral cavity odor: the hydrogen peroxide converts organic sulfides in the VSCs into inorganic sulfides with peculiar smell and organic sulfides without peculiar smell, and the inorganic sulfides are removed through reaction, so that the VSCs have remarkable peculiar smell removing effect; the zinc-containing compound can remove inorganic sulfide in the oral cavity, further remove bad breath, and has remarkable deodorizing effect on the bad breath and the organic sulfide remained after eating the onion, ginger and garlic.
The reaction of zinc ions to remove hydrogen sulfide is shown in the following formula (1):
Zn 2+ +H 2 S＝ZnS↓+2H +
(1)
The hydrogen sulfide removal reaction of hydrogen peroxide is shown in the following formula (2):
H O+H S＝＝2H O+S↓
(2)
The reaction of hydrogen peroxide to remove organic sulfide is typically, but not limited to, represented by the following formulas (3) and (4):
the methanesulfonic acid generated by the reaction of the formula (3) is colorless and odorless, and the sulfoxide substance generated by the reaction of the formula (4) is colorless and odorless, so that the problem of halitosis caused by organic sulfides is solved.
Further, the oral malodour-removing products include toothpastes, mouthwashes, mouth sprays, tooth cleaners, chewing gums and mouth rinses.
In a second aspect the present invention provides a toothpaste for removing malodour in the mouth, the toothpaste being a dual tube toothpaste comprising a zinc compound containing toothpaste and a hydrogen peroxide containing toothpaste;
the zinc-containing compound toothpaste comprises, by weight, 10-16 parts of an abrasive, 2.2-7.8 parts of a thickener, 0.38-1.14 parts of an anticariogenic agent, 1.1-3.3 parts of a foaming agent, 25-60 parts of a humectant, 0.4-8.5 parts of a whitening agent, 0.18-3.8 parts of a zinc-containing compound and 12-25 parts of deionized water.
The toothpaste for removing the oral cavity odor provided by the invention adopts the form of double-tube toothpaste, and the toothpaste containing hydrogen peroxide and zinc compounds is placed in two different tube cavities in a double-tube physical blocking manner, so that the stability of the hydrogen peroxide is prevented from being damaged by the zinc compounds or other chemical components in the common toothpaste, and the use effect and the shelf life of the toothpaste are ensured.
Because of the specificity of the hydrogen peroxide functional components, water, alkaline components, heavy metal substances and the like in the common raw material components of the toothpaste can catalyze and promote the decomposition of the hydrogen peroxide, so that the toothpaste body is inflated, the efficacy of the toothpaste in later use is reduced, and the shelf life of the toothpaste in storage is shortened. Hydrogen peroxide and zinc-containing compounds cannot be used in the same formulation, and zinc oxide or zinc ions catalyze the decomposition of hydrogen peroxide, resulting in both chemical bleaching and oxidation of hydrogen peroxide. Therefore, the toothpaste for removing the oral cavity peculiar smell is double-tube toothpaste, and mutually-reacted functional substances are separated, so that the stability of the functional substances is ensured.
In some embodiments of the present invention, a dual tube toothpaste container for oral malodor-removing toothpaste is configured to divide the interior space of the tube into two chambers, as in the dual-zone simultaneous extrusion container structure provided in application No. 202220631231.2 or 202222064080X, and a piston is provided in each chamber to engage with the separator and the interior of the tube; when the air bag compresses air, each piston realizes synchronous movement, so that the content in each cavity is synchronously extruded.
In some embodiments of the present invention, the weight parts of abrasive in the zinc compound containing toothpaste are typically, but not limited to, 10, 11, 12, 13, 14, 15, or 16; the parts by weight of thickener are typically, but not limited to, 2.2 parts, 3.2 parts, 4.2 parts, 5.2 parts, 6.2 parts, or 7.8 parts; the weight parts of anticaries agent are typically, but not limited to, 0.38 parts, 0.48 parts, 0.58 parts, 0.68 parts, 0.88 parts, or 1.14 parts; the weight parts of blowing agent are typically, but not limited to, 1.1 parts, 2.2 parts, or 3.3 parts; the parts by weight of humectant are typically, but not limited to, 25 parts, 35 parts, 45 parts, 55 parts, or 60 parts; the weight parts of the whitening agent are typically, but not limited to, 0.4 parts, 1.5 parts, 2.5 parts, 4 parts, 6 parts, 7 parts, or 8.5 parts; the parts by weight of zinc-containing compounds are typically, but not limited to, 0.18 parts, 0.5 parts, 1 part, 1.5 parts, 2 parts, 2.8 parts, or 3.8 parts and the parts by weight of deionized water are typically, but not limited to, 12 parts, 15 parts, 20 parts, or 25 parts.
When the weight part of the zinc-containing compound in the zinc-containing compound toothpaste is lower than 0.18 part, the conversion effect on the peculiar smell sulfide is poor, and after inorganic hydrogen sulfide is combined and reacted, the hydrogen peroxide oxidized organic sulfide is not catalyzed by excessive zinc-containing compound, so that the peculiar smell removing effect is not strong; when the weight part of the zinc-containing compound is higher than 3.8 parts, after inorganic hydrogen sulfide is reacted, the hydrogen sulfide can be catalyzed and oxidized by hydrogen peroxide better, and the zinc-containing compound can play a strong role in inhibiting anaerobic bacteria which metabolize to generate peculiar smell, so that the effect of removing the peculiar smell in the oral cavity is achieved.
Further, the hydrogen peroxide-containing toothpaste is a hydrogen peroxide-containing anhydrous toothpaste or a hydrogen peroxide-containing hydrous toothpaste.
When the weight part of PVP-hydrogen peroxide in the hydrogen peroxide-containing toothpaste is lower than 2 parts, the actual content of the converted hydrogen peroxide is lower than 0.4%, and the deodorizing effect of oxidized sulfide is not strong; when the PVP-hydrogen peroxide is higher than 18 parts by weight, the effect of removing the peculiar smell sulfide can be obviously mentioned, but the content of the PVP-hydrogen peroxide is higher than 3% and can cause the potential risk of oral mucosa tissue injury to a user.
Further, the anhydrous hydrogen peroxide-containing toothpaste comprises 30.1-44 parts of abrasive, 0.38-1.14 parts of anticariogenic agent, 1.4-2.8 parts of foaming agent, 3-10 parts of stabilizer, 5-20 parts of PEG-8, 10-20 parts of glycerin and 2-18 parts of PVP-hydrogen peroxide.
The saturated hydrogen peroxide solution has an acidity of about 4.5 and is thus stable at a weakly acidic pH, but has an oxidation effect superior to the whitening effect. In contrast, at alkaline pH, the whitening effect of hydrogen peroxide is better than that of oxidation, but is extremely easily decomposed into water and oxygen, making it difficult to preserve for a long period of time. To solve this problem, a stabilizer may be added to stabilize the hydrogen peroxide. PVP-hydrogen peroxide is used in the present invention, wherein PVP is polyvinylpyrrolidone and a stable complex of PVP with hydrogen peroxide via hydrogen bond is used. PVP-hydrogen peroxide has lower odor and better stability, is convenient for producing and using toothpaste, and provides good physical texture, viscosity and film forming effect. In some embodiments of the invention, the abrasive in the anhydrous hydrogen peroxide-containing toothpaste is typically, but not limited to, 30.1 parts, 32 parts, 34 parts, 36 parts, 40 parts, 42 parts, or 44 parts; anticaries agents are typically, but are not limited to, 0.38 parts, 0.58 parts, 0.78 parts, 0.98 parts, 1.08 parts, or 1.14 parts; the blowing agent is typically, but not limited to, 1.4 parts, 1.8 parts, 2.2 parts, 2.6 parts, or 2.8 parts; stabilizers are typically, but are not limited to, 3 parts, 5 parts, 7 parts, 9 parts, or 10 parts; PEG-8 is typically, but not limited to, 5 parts, 8 parts, 12 parts, 15 parts, 18 parts, 20 parts; glycerol is typically, but not limited to, 10 parts, 12 parts, 14 parts, 16 parts, 18 parts, 20 parts; PVP-hydrogen peroxide is typically, but not limited to, 2, 6, 10, 14 or 18 parts.
Further, the aqueous hydrogen peroxide-containing toothpaste comprises 5-15 parts of wetting agent, 0.2-1.2 parts of thickener, 0.2-0.8 parts of buffer, 5-15 parts of PEG-8, 40-75 parts of deionized water and 2-18 parts of PVP-hydrogen peroxide.
In some embodiments of the present invention, the humectant is typically, but not limited to, 5 parts, 7 parts, 9 parts, 11 parts, 13 parts, or 15 parts in a hydrogen peroxide containing aqueous toothpaste; thickeners are typically, but are not limited to, 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 part, or 1.2 parts; buffers are typically, but are not limited to, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, or 0.8 parts; PEG-8 is typically, but not limited to, 5, 7, 9, 11, 13 or 15 parts; deionized water is typically but not limited to 40, 50, 60, 70 or 75 parts and PVP-hydrogen peroxide is typically but not limited to 2, 6, 10, 14 or 18 parts.
In aqueous hydrogen peroxide toothpastes, the buffer acts to neutralize the pH of the thickener itself, reducing the decomposition of the thickener to PVP-hydrogen peroxide.
Further, the zinc-containing compound includes at least one of zinc citrate, zinc oxide, zinc chloride, and zinc gluconate.
Further, the abrasive comprises at least one of calcium pyrophosphate, calcium hydrogen phosphate, calcium carbonate, calcium hydrogen phosphate dihydrate, and abrasive silica.
Preferably, the anticaries agent includes at least one of sodium monofluorophosphate, sodium fluoride, and stannous fluoride.
Preferably, the emulsifier comprises at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate and cocamidopropyl betaine.
Preferably, the thickener comprises at least one of carbomers, thickening silica, cellulose gum and xanthan gum.
Further, the stabilizer comprises at least one of fumed silica, polyacrylic acid, polyvinylpyrrolidone, and PEG/PPG-116/66 copolymer.
Preferably, the wetting agent comprises glycerol and/or propylene glycol.
Preferably, the buffering agent comprises sodium hydroxide, sodium bicarbonate.
Preferably, the humectant comprises sorbitol, PEG-8, glycerin and propylene glycol.
Preferably, the whitening agent comprises tetrasodium pyrophosphate and/or sodium percarbonate.
Further, the zinc compound-containing toothpaste, the hydrogen peroxide-containing anhydrous toothpaste or the hydrogen peroxide-containing hydrated toothpaste further comprises a flavor or sweetener.
Preferably, the sweetener comprises sucralose.
Some embodiments of the present invention will be described in detail below with reference to examples. The following embodiments and features of the embodiments may be combined with each other without conflict. The raw materials in the following examples and comparative examples are commercially available without specifying the conditions.
Example 1
The embodiment provides a toothpaste for removing bad breath, which is double-tube toothpaste, and the specific formula information is as follows:
zinc compound containing toothpaste formulation, 100 kg: 13kg of friction silica, 4kg of thickening silica, 0.55kg of cellulose gum, 0.45kg of xanthan gum, 0.76kg of sodium monofluorophosphate, 0.1kg of sucralose, 1.75kg of sodium lauryl sulfate, 0.45kg of cocamidopropyl betaine, 1.1kg of essence, 4kg of PEG-8, 42.5kg of sorbitol, 1.1kg of tetrasodium pyrophosphate, 3.05kg of sodium bicarbonate, 0.3kg of titanium dioxide, 0.44kg of zinc citrate, 1.55kg of zinc oxide and 18.5kg of deionized water.
Aqueous hydrogen peroxide toothpaste formulation, 100 kg: 10kg of glycerol, 10kg of PEG-8, 0.7kg of carbomer (956), 57.5kg of deionized water, 0.25kg of sucralose, 10kg of PVP-hydrogen peroxide, 0.3kg of essence and 0.5kg of sodium hydroxide.
Example 2
The embodiment provides a toothpaste for removing bad breath, which is double-tube toothpaste, and the specific formula information is as follows:
zinc compound containing toothpaste formulation: as in example 1.
A hydrogen peroxide-containing anhydrous toothpaste formulation, based on 100 kg: 35kg of calcium pyrophosphate, 2kg of disodium dihydrogen pyrophosphate, 0.76kg of sodium monofluorophosphate, 0.85kg of carbomer, 6.5kg of fumed silica, 0.11kg of sucralose, 1.5kg of sodium lauryl sulfate, 0.6kg of cocamidopropyl betaine, 1.1kg of essence, 17.5kg of PEG-8, 20kg of glycerin and 10kg of PVP-hydrogen peroxide.
Example 3
The embodiment provides a toothpaste for removing bad breath, which is double-tube toothpaste, and the specific formula information is as follows:
zinc compound containing toothpaste formulation: unlike example 1, zinc oxide was not used, zinc citrate was used in an amount of 2kg, and the remaining raw materials were the same as example 1, and will not be described here again.
Aqueous hydrogen peroxide containing toothpaste formulation: as in example 1.
Example 4
The embodiment provides a toothpaste for removing bad breath, which is double-tube toothpaste, and the specific formula information is as follows:
zinc compound containing toothpaste formulation: unlike example 1, zinc oxide 1kg and zinc gluconate 1kg were used instead of zinc citrate and zinc oxide, and the remaining raw materials were the same as in example 1 and will not be described again.
Aqueous hydrogen peroxide containing toothpaste formulation: as in example 1.
Example 5
The embodiment provides a toothpaste for removing bad breath, which is double-tube toothpaste, and the specific formula information is as follows:
zinc compound containing toothpaste formulation: unlike example 1, zinc citrate 0.08kg and zinc oxide 1.91kg, and the rest of the raw materials are the same as example 1, and are not described here again.
Aqueous hydrogen peroxide containing toothpaste formulation: as in example 1.
Example 6
The embodiment provides a toothpaste for removing bad breath, which is double-tube toothpaste, and the specific formula information is as follows:
zinc compound containing toothpaste formulation: unlike example 1, zinc citrate 0.8kg and zinc oxide 1.19kg, and the rest of the raw materials are the same as example 1, and are not described here again.
Aqueous hydrogen peroxide containing toothpaste formulation: as in example 1.
Example 7
The embodiment provides a toothpaste for removing bad breath, which is double-tube toothpaste, and the specific formula information is as follows:
zinc compound containing toothpaste formulation: as in example 1.
Aqueous hydrogen peroxide containing toothpaste formulation: unlike example 1, PVP-hydrogen peroxide was 2kg, and the remaining materials were the same as in example 1, and will not be described again.
Example 8
The embodiment provides a toothpaste for removing bad breath, which is double-tube toothpaste, and the specific formula information is as follows:
zinc compound containing toothpaste formulation: as in example 1.
Aqueous hydrogen peroxide containing toothpaste formulation: unlike example 1, PVP-hydrogen peroxide was 18kg, and the remaining materials were the same as in example 1, and will not be described again.
Comparative example 1
The comparative example provides a toothpaste for removing bad breath, which is a single tube hydrogen peroxide-containing aqueous toothpaste, wherein the formulation of the hydrogen peroxide-containing aqueous toothpaste is the same as that of example 1, and the description thereof is omitted.
Comparative example 2
The comparative example provides a toothpaste for removing bad breath, which is a single tube zinc-containing compound toothpaste formulation, wherein the zinc-containing compound toothpaste formulation is the same as that of example 1, and is not repeated herein.
Comparative example 3
The comparative example provides a common toothpaste, which comprises the following ingredients in 100 kg: 16kg of friction silica, 4kg of thickening silica, 0.4kg of cellulose gum, 0.5kg of xanthan gum, 0.76kg of sodium monofluorophosphate, 0.13kg of sucralose, 2.2kg of sodium lauryl sulfate, 1.0kg of essence, 8kg of PEG-8, 40kg of sorbitol, 0.5kg of sodium bicarbonate, 0.3kg of titanium dioxide, 0.03kg of methyl hydroxybenzoate, 0.07kg of propyl hydroxybenzoate and 26.11kg of deionized water.
Experimental example 1
The toothpastes obtained in example 1, comparative example 1 and comparative example 2 were simulated using a garlic soak solution more complex than the characteristic bad breath volatile sulfides (Volatile sulfur compounds, VSCs) of human mouth, and tested for H using an Oralchroma halitosis detector 2 S、CH 3 SH and (CH) 3 ) 2 And S three index.
The specific test process is as follows: the toothpaste of the example 1, the comparative example 1 and the comparative example 2 is diluted into toothpaste slurry with the concentration of 20 percent of the original concentration by deionized water, 9mL of the toothpaste slurry is respectively taken in 3 sealed test tubes with rubber covers, and 1mL of saturated garlic water soaking solution is respectively added; and (4) after 9mL of deionized water is added into the sealed test tube with the rubber cover, 1mL of saturated garlic water soaking solution is added as a blank group, and after the 4 test tubes are subjected to shaking reaction for 3min, the test tube is kept stand for testing. 1mL of gas above a sealed test tube with a rubber cover is sucked by pushing and pulling a 1mL syringe with a needle for multiple times, and is injected into an Oralchroma halitosis detector to test H 2 S、CH 3 SH and (CH) 3 ) 2 The S three index data are shown in table 1 below:
TABLE 1
As can be seen from Table 1, the single functional ingredientThe effect on organic sulfides was not as good as that of the toothpaste of example 1 using the combination of the toothpaste of comparative example 1 and the toothpaste of comparative example 2 containing zinc compound. Hydrogen peroxide or zinc-containing compounds to H 2 S has obvious removal effect, but has poor removal effect on organic sulfide mercaptan and thioether, and is inferior to the effect of the two in compound use.
Experimental example 2
The toothpastes obtained in examples 1 to 8 and comparative examples 1 to 3 were subjected to a halitosis removing effect test. The simulation was performed using a garlic dip more complex than the human oral characteristic off-flavor volatile sulfides (Volatile sulfur compounds, VSCs). The test uses saturated garlic soaking liquid, the toothpaste is diluted into toothpaste slurry with the concentration of 20% of the original concentration, 9mL of toothpaste slurry is taken, 1mL of saturated garlic soaking liquid is added into the toothpaste slurry for reaction, and the reaction is kept for 3min. And performing gas chromatography on the obtained mixed solution.
The saturated garlic water soaking liquid is characterized by a gas chromatography-mass spectrometer, the retention time of organic sulfides such as mercaptan, thioether, disulfide and the like with characteristic peculiar smell is found through analysis by a GCMS database of fresh garlic water, the retention time is used as a reference substance, and data comparison and analysis are carried out, so that the obtained GCMS database is shown in the following table 2.
TABLE 2
As can be seen from Table 2, in the GCMS database of saturated garlic water soaking liquid, the peak numbers 3-8 and 12, 13 are characteristic peaks. The sulfide corresponding to the retention time is used as a reference substance for data comparison and analysis.
The GCMS database of the mixed solution obtained in example 1 is shown in Table 3 below.
TABLE 3 Table 3
As can be seen from table 3, the retention time of peak number 6 is 21.47, which is methyl 2-propenyl disulfide, one of the characteristic odor components of garlic, leek and shallot aroma, the peak area is 1475673, and the removal rate of peak area 4122942 corresponding to the same component is 64% compared with the same retention time of garlic water soaking liquid in table 2; the retention time of the peak number 16 is 24.85, diallyl disulfide is a garlic special odor, the peak area is 4644705, and compared with the peak area 9959464 removal rate of the same components corresponding to the same retention time of the garlic water soaking liquid in the table 2, the removal rate is 53%; the retention time of peak number 17 is 25.24, which is cis-propenyl isopropenyl disulfide and trans-propenyl-isopropenyl disulfide, the peak area is 969630, and compared with the peak area 1571931 removal rate of the same components corresponding to the same retention time of the garlic water soaking liquid in table 2, the retention time is 25.24, and the garlic odor removal effect is stronger.
The GCMS database of the mixed solution obtained in comparative example 1 is shown in Table 4 below.
TABLE 4 Table 4
As can be seen from table 4, peaks 8 and 14 are diallyl sulfide and methyl 1-cis-propenyl disulfide, showing the oxidizing property of hydrogen peroxide to sulfide with a reduced peak area compared to the corresponding retention time in table 2, and the absence of the detected signal of this material in table 3 corresponding to example 1 illustrates the catalytic promotion of the oxidation of hydrogen peroxide by zinc compounds to completely convert this material; peak numbers 26 and 27, retention times 24.85 and 25.24, respectively, were greater than the corresponding peak areas or peak heights for the retention times of table 3, again indicating the significant effect of the synergistic interaction of the zinc-containing compound with hydrogen peroxide.
The GCMS database of the mixture obtained in comparative example 2 is shown in Table 5 below.
TABLE 5
As can be seen from Table 5, peak No. 5 is propylene sulfide, peak No. 9 is methyl 2-propenyl disulfide, peak No. 11 is methyl 1-cis-propenyl disulfide or methyl 1-trans-propenyl disulfide, peak No. 25 is diallyl disulfide, and the sulfur-containing compounds corresponding to the retention time in Table 2 are reduced, but the effect of removing such sulfides is weaker than in comparative example and example 1. Peak No. 26 is cis-propenyl isopropenyl disulfide and trans-propenyl-isopropenyl disulfide, and the peak area and peak height of the substances in table 2 are increased compared with those of the substances in table 2, which is caused by the increase of trace amount of the essence component, and peak No. 25 diallyl disulfide also has signal response in toothpaste essence. Peak No. 6 is non-sulfur alcohol and ether component carried in toothpaste essence, and the garlic soaking liquid does not contain the component.
The GCMS database of the mixture obtained in comparative example 3 is shown in Table 6 below.
TABLE 6
As can be seen from Table 6, the corresponding response signals of peak numbers 5-8 are shown in Table 2, and the retention time corresponds to the peak area and peak height, and the peak area and peak height are lower and higher, on one hand, due to the increase caused by the essence, and on the other hand, due to the porous structure of silica in the common toothpaste, trace organic sulfur-containing compounds are adsorbed. Peak number 11 is methyl 2-propenyl disulfide, peak number 26 is diallyl disulfide, peak number 28 is cis-propenyl isopropenyl disulfide and trans-propenyl-isopropenyl disulfide, and peak areas and peak heights in comparison table 2 are both higher, and are brought in by the toothpaste essence containing the trace substances.
The GCMS data graphs of examples 2-7 show that the synergistic use of the zinc oxide and zinc citrate combined double zinc component and the pvp-hydrogen peroxide has the effect of obviously removing the peculiar smell of the complex volatile sulfur-containing compound, and is better than the use effect of a single effective component; the zinc compound-containing oral care product and the hydrogen peroxide-containing oral care product with single functional components have certain limit on the effect of removing complex volatile sulfur compounds, and the hydrogen peroxide removal effect is superior to that of the zinc compound; in addition, the zinc-containing compound and the hydrogen peroxide are combined in the formulation design of the oral cavity odor removal product, when the stability of the hydrogen peroxide is considered, the composition components of the essence which react with the hydrogen peroxide should be controlled, otherwise, the oral cavity odor removal effect is weakened in the use process.
The data in tables 2-6 above show that example 1, comparative example 1 and comparative example 2, which are highly effective in catalyzing the oxidation of organic sulfides having characteristic off-flavors such as mercaptans, sulfides, disulfides, etc. in garlic, the reaction mechanism of hydrogen peroxide in example 1, which interacts with zinc-containing compounds, necessarily produces intermediate species capable of oxidizing organic sulfides having characteristic off-flavors, if none of these sulfides participate in the reaction, otherwise only the simple catalytic decomposition of hydrogen peroxide produces oxygen, which is why both cannot be contacted directly for a long period of time, while at the same time in a toothpaste formulation. In comparative example 3, the organic sulfide of a part of characteristic peculiar smell was increased because the general toothpaste slurry contained essence, and the composition of the essence contained volatile sulfide. When the concentration of organic sulfide with characteristic peculiar smell in the essence is controlled below the human olfactory threshold, people feel aromatic, and the application of the excrement malodor-like essence in ice cream and perfume, ambergris and the like are realized.
Finally, it should be noted that the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art will appreciate that; the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.
Claims (10)
1. Use of a zinc compound in combination with hydrogen peroxide in a product for the removal of malodour.
2. The use according to claim 1, wherein the oral malodour-removing products comprise toothpastes, mouthwashes, mouth sprays, tooth-cleaning powders, chewing gums and mouth cleaners.
3. A toothpaste for removing bad breath, which is characterized in that the toothpaste is a double tube toothpaste, comprising a zinc compound toothpaste and a hydrogen peroxide toothpaste;
the zinc-containing compound toothpaste comprises, by weight, 10-16 parts of an abrasive, 2.2-7.8 parts of a thickener, 0.38-1.14 parts of an anticariogenic agent, 1.1-3.3 parts of a foaming agent, 25-60 parts of a humectant, 0.4-8.5 parts of a whitening agent, 0.18-3.8 parts of a zinc-containing compound and 12-25 parts of deionized water.
4. A toothpaste according to claim 3, wherein the hydrogen peroxide containing toothpaste is a hydrogen peroxide containing anhydrous toothpaste or a hydrogen peroxide containing hydrated toothpaste.
5. The toothpaste according to claim 4, wherein the anhydrous hydrogen peroxide-containing toothpaste comprises 30.1 to 44 parts of abrasive, 0.38 to 1.14 parts of anticaries agent, 1.4 to 2.8 parts of foaming agent, 3 to 10 parts of stabilizer, 5 to 20 parts of PEG-8, 10 to 20 parts of glycerin and 2 to 18 parts of PVP-hydrogen peroxide.
6. The toothpaste according to claim 4, wherein the aqueous hydrogen peroxide containing toothpaste comprises 5-15 parts of humectant, 0.2-1.2 parts of thickener, 0.2-0.8 parts of buffer, 5-15 parts of PEG-8, 40-75 parts of deionized water and 2-18 parts of PVP-hydrogen peroxide.
7. The toothpaste of any one of claims 3-6, wherein the zinc-containing compound comprises at least one of zinc citrate, zinc oxide, zinc chloride, and zinc gluconate.
8. The toothpaste of any one of claims 3-6, wherein the abrasive comprises at least one of calcium pyrophosphate, calcium hydrogen phosphate, calcium carbonate, calcium hydrogen phosphate dihydrate, and abrasive silica;
preferably, the anticaries agent comprises at least one of sodium monofluorophosphate, sodium fluoride, and stannous fluoride;
preferably, the foaming agent comprises at least one of sodium lauryl sulfate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate and cocamidopropyl betaine;
preferably, the humectant comprises sorbitol, PEG-8, glycerin and propylene glycol;
preferably, the whitening agent comprises tetrasodium pyrophosphate and/or sodium phytate.
9. The toothpaste of claim 5 or 6, wherein the stabilizing agent comprises at least one of fumed silica, polyacrylic acid, polyvinylpyrrolidone, and PEG/PPG-116/66 copolymer;
preferably, the thickener comprises at least one of carbomers, thickening silica, cellulose gum and xanthan gum;
preferably, the wetting agent comprises glycerol and/or propylene glycol;
preferably, the buffering agent comprises sodium hydroxide, sodium bicarbonate.
10. The toothpaste according to any one of claims 3-6, further comprising a flavor or sweetener in said zinc compound containing toothpaste, said hydrogen peroxide containing anhydrous toothpaste, or said hydrogen peroxide containing aqueous toothpaste;
preferably, the sweetener comprises sucralose.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104010653A (en) * | 2011-10-31 | 2014-08-27 | 凯恩生物科技有限公司 | Compositions And Methods For Preventing And Treating Oral Diseases |
| CN104853727A (en) * | 2012-12-19 | 2015-08-19 | 高露洁-棕榄公司 | Oral care products comprising zinc oxide and trimethylglycine |
| CN110123669A (en) * | 2014-06-20 | 2019-08-16 | 高露洁-棕榄公司 | Oral cavity composition containing metal ion |
| US20210022967A1 (en) * | 2018-06-18 | 2021-01-28 | Bo Tao | Multi-component oral care formulation and multi-compartment delivery systems thereof |
-
2023
- 2023-03-01 CN CN202310186041.3A patent/CN116270266A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104010653A (en) * | 2011-10-31 | 2014-08-27 | 凯恩生物科技有限公司 | Compositions And Methods For Preventing And Treating Oral Diseases |
| CN104853727A (en) * | 2012-12-19 | 2015-08-19 | 高露洁-棕榄公司 | Oral care products comprising zinc oxide and trimethylglycine |
| CN110123669A (en) * | 2014-06-20 | 2019-08-16 | 高露洁-棕榄公司 | Oral cavity composition containing metal ion |
| US20210022967A1 (en) * | 2018-06-18 | 2021-01-28 | Bo Tao | Multi-component oral care formulation and multi-compartment delivery systems thereof |
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